                                   Chemical
                Test Results
Ocular Lesion & Severity Score
             Current HCS Classification 
(FHSA:  16 CFR 1500.42)
                       GHS (as proposed) Classification
                   Other Hazards Identified in Quick Search
cis-Cyclo-octene
4/6 positive; 
CR=2
Irritant
Non-Irritant
Solvent-type CNS effects likely; Not otherwise a health hazard;
Would be a Category 3 Flammable Liquid (flash point ~86°F)
Fomesafen, acid form (solid)
45/6 positive; 
2/6 CO=1, 
12/6 IR=1, 
4/6 CR=2, 
2/6 CC=2
Irritant
Non-Irritant
Acute toxicant, oral, Cat 4. (rat oral LD50 1250-2000 mg/kg)
Sodium lauryl sulfate (3%)
5/6 positive; 
4/6 CO=1 or 2, 
5/6 CR=2, 
3/6 CC=2
Irritant
Non-Irritant
(Severe) Eye irritant at higher concentration(s)
Ethyl acetate
4/4 positive; 
4/4 CO=1 or 2, 
1/4 IR=1, 
3/4 CR=2
Irritant
(day 1 effects only)
Non-Irritant
Not otherwise a health hazard;
Would be a Category 2 Flammable Liquid (flash point ~55°F; BP ~77°F)
Methyl amyl ketone (1X)
3/4 positive; 
3/4 CO=1, 
1/4 IR=1, 
1/4 CR=2,
1/4 CC=2 or 3
Irritant
Non-Irritant
Solvent-type CNS effects; traditionally considered to be a respiratory irritant;
Would be a Category 3 Flammable Liquid (flash point ~102°F)
Methyl amyl ketone (2X)
3/4 positive; 
3/4 CO=1, 
2/4 IR=2, 
3/4 CR=2,
3/4 CC=2
Irritant
Non-Irritant
(see above)
Toluene
3/3 positive; 
3/4 CR=2, 
3/4 CC=2
Irritant
Non-Irritant
(variety of physical and health hazards)
Xylene (1X)
0/4 positive
Non-Irritant
Non-Irritant
Target organ toxicity, CNS depression; Cat 3 Flammable Liquid (flash point ~30-35°C)
Xylene (2X)
4/4 positive; 
2/4 CR=2, 
4/4 CC=2
Irritant
Non-Irritant
(see above)
2,2-Dimethyl-3-pentanol
2/3 positive; 
2/3 CO=1 or 2, 
3/3 CC=2
Irritant
Non-Irritant
Cat 3 Flammable Liquid (flash point ~35-38°C)
N,N-Dimethylguanidine sulfate
3/3 positive; 
CR=2
Irritant
Non-Irritant
Not an Irritant or Sensitizer; EU criteria (No other data found)
Ethyl thioglycolate
2/3 positive; 
2/3 CO=1 to 3, 
2/3 IR=1, 
2/3 CR=2 to 3, 
2/3 CC=2
Irritant
Non-Irritant
Acute toxicant, oral, Cat 3. (rat oral LD50 178 mg/kg)
Glycidyl methacrylate
3/3 positive; 
3/3 CO=1 to 2, 
32/3 IR=1, 
3/3 CR=2 to 3, 
1/3 CC=2 to 4
Irritant
Non-Irritant
Acute toxicant, oral, Cat 4. (rat oral LD50 500 mg/kg); also reported as severe skin irritant, which would probably cause an Assessor to label as an eye irritant
Myristyl myristate
3/3 positive; 
1/3 CO=1; 
2/3 CR=2 to 3
0/3 positive; 
0/3 CO = >=1
0/3 IR = >=1
0/3 CR = >=2
0/3 CC = >=2
Non-Irritant
Non-Irritant
Not a rat oral acute toxicant (LD50 > 14 g/kg; no other data found)
Tetraaminopyrimidine sulfate
2/3 positive; 
2/3 CO=1 to 2, 
2/3 CR=2
Irritant
Non-Irritant
Not an acute or chronic toxicant; Identified as non-irritating by EU Scientific Committee on Cosmetic Products and Non-Food Products intended for
Consumers (SCCNFP)





Cellosolve Acetate
3/4 positive; 
1/4 CO=1 to 2, 
0/4 IR=1, 
3/4 CR=2,
1/3 CC=2
Irritant
Non Irritant
Glycol ether reproductive effects
1,4-Dibromobutane
1/3 positive; 
1/3 CO=2, 
1/3 CR=2
Non-Irritant
Non-Irritant
Positive mutagenesis data (Ames; several strains) and positive in vitro Chromosomal Aberrations
Abbreviations:
CC = conjunctival chemosis (swelling); 
CO = corneal opacity; 
CR = conjunctival redness; 
IR = iritis
