
                         SUPPORTING STATEMENT FOR THE
                  INFORMATION COLLECTION REQUIREMENTS OF THE
                 STANDARD ENTITLED "OCCUPATIONAL EXPOSURE TO
           HAZARDOUS CHEMICALS IN LABORATORIES" (29 CFR 1910.1450)
                     OFFICE OF MANAGEMENT AND BUDGET (OMB)
                      CONTROL NO. 1218-0131 (March 2022)

This ICR is requesting the extension of a currently approved data collection.


A.  JUSTIFICATION

 1.	Explain the circumstances that make the collection of information necessary.  Identify any legal or administrative requirements that necessitate the collection.  Attach a copy of the appropriate section of each statute and regulation mandating or authorizing the collection of information.

The main purpose of the Occupational Safety and Health Act ("OSH Act" or "Act") is to "assure so far as possible every working man and woman in the Nation safe and healthful working conditions and to preserve our human resources" (29 U.S.C. 651).  To achieve this objective, the OSH Act specifically authorizes "the development and promulgation of occupational safety and health standards" (29 U.S.C. 651).  The Act states further that "[t]he Secretary . . . shall prescribe such rules and regulations as [he/she] may deem necessary to carry out [his/her] responsibilities under this Act, including rules and regulations dealing with the inspection of an employer's establishment" (29 U.S.C. 651).

To protect worker health, the OSH Act authorizes the Occupational Safety and Health Administration ("OSHA" or "Agency") to develop standards that provide for "monitoring or measuring worker exposure" to occupational hazards and "prescribe the type and frequency of medical examinations and other tests which shall be made available [by the employer] to workers exposed to such hazards . . . to most effectively determine whether the health of such workers is adversely affected by such exposure" (29 U.S.C. 655).  Moreover, the Act directs OSHA to "issue regulations requiring employers to maintain accurate records of worker exposures to potentially toxic materials or other harmful physical agents which are required to be monitored and measured . . . " (29 U.S.C. 657).  In addition, the OSH Act mandates that "[e]ach employer shall make, keep and preserve, and make available to the Secretary [of Labor] . . . such records regarding [the employer's] activities relating to this Act as the Secretary . . . may prescribe by regulation as necessary or appropriate for the enforcement of this Act . . ." (29 U.S.C. 657).

The Act authorizes the Agency to issue standards that "prescribe use of labels or other appropriate forms of warning as are necessary to ensure that workers are apprised of all hazards to which they are exposed, relevant symptoms and appropriate emergency treatment, and proper conditions and precautions of safe use or exposure" (29 U.S.C. 655).  Additionally, the OSH Act mandates that "[e]ach employer shall make, keep and preserve, and make available to the Secretary . . . such records . . . as the Secretary . . . may prescribe by regulation as necessary or appropriate for the enforcement of this Act . . ."  (29 U.S.C. 657).

Beginning in the early 1970s, OSHA published numerous health standards to control worker exposure to toxic substances in 29 CFR part 1910, subpart Z (the "subpart Z standards").  However, OSHA developed the subpart Z standards primarily to protect workers exposed to toxic substances during industrial operations.  These operations typically involve exposure to a few toxic substances emitted during a standardized and continuous or repetitive process that uses large quantities of the toxic substances.  In laboratories, workers use small quantities of numerous hazardous chemicals in a variety of analytic and clinical procedures and operations, each of which they perform infrequently or periodically.  In addition, standard laboratory practices often require techniques that control the release of, and exposure to, hazardous chemicals (e.g., extensive labeling, sealed containers, protective clothing, fume hoods).  Moreover, laboratory workers have better knowledge of the hazardous chemicals with which they work than do workers involved in typical industrial operations; based on the high level of training they receive, laboratory workers usually have a thorough understanding of the chemical properties of these substances, as well as the safety and health problems associated with them.

Based on this evidence, OSHA concluded that, in general, laboratory workers have minimal exposures to hazardous chemicals in the workplace (i.e., below the action level (i.e., "AL") or, in the absence of an AL, the permissible exposure limit ("PEL") specified by subpart Z for any of these substances).  Therefore, under the authority granted by the OSH Act, the Agency published a health standard governing occupational exposure to hazardous chemicals in laboratories (29 CFR 1910.1450; the "Standard").

 2.  	Indicate how, by whom, and for what purpose the information is to be used.  Except for a new collection, indicate the actual use the Agency has made of the information received from the current collection.

The Standard contains a number of paperwork requirements.  The following paragraphs describe these requirements, specify who uses them, and what purpose they serve.

A.  Worker exposure determination (§1910.1450(d))

Initial monitoring (§1910.1450(d)(1))

The employer shall measure the worker's exposure to any substance regulated by a Standard which requires monitoring if there is reason to believe that exposure levels for that substance routinely exceed the action level (or in the absence of an action level, the PEL).

Purpose:  Initial monitoring assists employers in identifying procedures and operations that require modification to reduce exposures to the AL or PEL specified by the appropriate subpart Z standard.  In this regard, initial monitoring results enable employers to determine the need for engineering controls, institute new (or modify existing) work practices, and select appropriate respiratory protection to prevent worker overexposure.  This information also determines whether or not the employer must perform periodic monitoring.

Periodic monitoring (§1910.1450(d)(2))

§1910.1450(d)(2) - If the initial monitoring prescribed by paragraph (d)(1) of this section discloses worker exposure over the action level (or in the absence of an action level, the PEL), the employer shall immediately comply with the exposure monitoring provisions of the relevant Standard.

Purpose:  Employers use periodic monitoring results to evaluate the effectiveness of selected control methods.  In addition, these measurements remind both the employer and workers of the need to protect workers against the effects of overexposure to hazardous chemicals in laboratory facilities.  These monitoring data will also inform the examining physician of the existence and extent of a worker's exposure to the hazardous chemical(s) for use in assessing the worker's medical condition.

Termination of monitoring (§1910.1450(d)(3))

Monitoring may be terminated in accordance with the relevant standard.

Worker notification of monitoring results (§1910.1450(d)(4))

The employer shall, within 15 working days after the receipt of any monitoring results, notify the worker of these results in writing either individually or by posting the results in an appropriate location that is accessible to workers.

Purpose:  Notification provides workers with information they can use to assess the effectiveness of the controls their employer implements to reduce their exposures to hazardous 
laboratory chemicals, and to determine if any medical signs and symptoms they may be experiencing could be the result of their exposure to these chemicals.

B.  Chemical Hygiene Plan (CHP) (§1910.1450(e))

§1910.1450(e)(1) - Where hazardous chemicals as defined by this Standard are used in the workplace, the employer shall develop and carry out the provisions of a written Chemical Hygiene Plan which is:

§1910.1450(e)(1)(i) - Capable of protecting workers from health hazards associated with hazardous chemicals in that laboratory, and

§1910.1450(e)(1)(ii) - Capable of keeping exposures below the limits specified in paragraph (c) of this section.

§1910.1450(e)(2)- The Chemical Hygiene Plan shall be readily available to employees, and employee representatives;

§1910.1450(e)(3) - The Chemical Hygiene Plan shall include each of the following elements and shall indicate specific measures that the employer will take to ensure laboratory worker protection:

§1910.1450(e)(3)(i) - Standard operating procedures relevant to safety and health considerations to be followed when laboratory work involves the use of hazardous chemicals;

§1910.1450(e)(3)(ii) - Criteria that the employer will use to determine and implement control measures to reduce worker exposure to hazardous chemicals including engineering controls, the use of personal protective equipment and hygiene practices; particular attention shall be given to the selection of control measures for chemicals that are known to be extremely hazardous;

§1910.1450(e)(3)(iii) - A requirement that fume hoods and other protective equipment are functioning properly and specific measures that shall be taken to ensure proper and adequate performance of such equipment;

§1910.1450(e)(3)(iv) - Provisions for worker information and training as prescribed in paragraph (f) of this section;

§1910.1450(e)(3)(v) - The circumstances under which a particular laboratory operation, procedure or activity shall require prior approval from the employer or the employer's designee before implementation;

§1910.1450(e)(3)(vi) - Provisions for medical consultation and medical examinations in accordance with paragraph (g) of this section;

§1910.1450(e)(3)(vii) - Designation of personnel responsible for implementation of the Chemical Hygiene Plan including the assignment of a Chemical Hygiene Officer, and, if appropriate, establishment of a Chemical Hygiene Committee; and

§1910.1450(e)(3)(viii) - Provisions for additional worker protection for work with particularly hazardous substances. These include "select carcinogens," reproductive toxins and substances which have a high degree of acute toxicity. Specific consideration shall be given to the following provisions which shall be included where appropriate:
      
      §1910.1450(e)(3)(viii)(A) - Establishment of a designated area;

      §1910.1450(e)(3)(viii)(B) - Use of containment devices such as fume hoods or glove
                             boxes;

      §1910.1450(e)(3)(viii)(C) - Procedures for safe removal of contaminated waste; and

      §1910.1450(e)(3)(viii)(D) - Decontamination procedures.

§1910.1450(e)(4) - The employer shall review and evaluate the effectiveness of the Chemical Hygiene Plan at least annually and update it as necessary.

Purpose:  This requirement commits employers to evaluate worker exposures to hazardous laboratory chemicals and establish an organized and complete program for reducing these exposures to the PEL specified for these chemicals.  The requirement to review and update the CHP ensures that employers continue to evaluate workplace conditions, including hazardous-chemical exposures, and to implement the controls required to reduce worker overexposures.   Employers are required to develop a written Chemical Hygiene Plan and ensure that they carry out the provisions.

C.  Worker Information and Training (§1910.1450(f))

§1910.1450(f)(1) - The employer shall provide workers with information and training to ensure that they are apprised of the hazards of chemicals present in their work area.

§1910.1450(f)(2) - Such information shall be provided at the time of a worker's initial assignment to a work area where hazardous chemicals are present and prior to assignments involving new exposure situations. The frequency of refresher information and training shall be determined by the employer.

§1910.1450(f)(3) - Workers shall be informed of:

§1910.1450(f)(3)(i) - The contents of this standard and its appendices which shall be made available to them;

§1910.1450(f)(3)(ii) -The location and availability of the employer's Chemical Hygiene Plan;

§1910.1450(f)(3)(iii) - The permissible exposure limits for OSHA regulated substances or recommended exposure limits for other hazardous chemicals where there is no applicable OSHA standard;

§1910.1450(f)(3)(iv) - Signs and symptoms associated with exposures to hazardous chemicals used in the laboratory; and

§1910.1450(f)(3)(v) - The location and availability of known reference material on the hazards, safe handling, storage and disposal of hazardous chemicals found in the laboratory including, but not limited to, Safety Data Sheets, (SDSs) received from the chemical supplier.

Training (§1910.1450(f)(4))

§1910.1450(f)(4)(i) - Worker training shall include:

§1910.1450(f)(4)(i)(A) - Methods and observations that may be used to detect the 	presence or release of a hazardous chemical (such as monitoring conducted by the employer, continuous monitoring devices, visual appearance or odor of hazardous chemicals when being released, etc.);

§1910.1450(f)(4)(i)(B) - The physical and health hazards of chemicals in the work area; and

§1910.1450(f)(4)(i)(C) - The measures workers can take to protect themselves from these hazards, including specific procedures the employer has implemented to protect workers from exposure to hazardous chemicals, such as appropriate work practices, emergency procedures, and personal protective equipment to be used.
      
§1910.1450(f)(4)(ii) - The worker shall be trained on the applicable details of the employer's written Chemical Hygiene Plan.

Purpose:  This requirement is essential to inform workers of the health hazards resulting from hazardous chemical exposure and to provide them with the understanding necessary to minimize these hazards.  Training serves to explain and reinforce the information presented to workers on signs, labels, and SDSs; however, this information will be effective only if workers understand the information and can take the actions necessary to avoid or minimize hazardous chemical 
exposure.  Training also enables workers to recognize operations and locations associated with hazardous chemical exposures, thereby, permitting them to limit exposure from these sources.

D.  Medical Consultation and Medical Examinations (§1910.1450(g))

General (§1910.1450(g)(1) and (g)(2))

§1910.1450(g)(1) - The employer shall provide all workers who work with hazardous chemicals an opportunity to receive medical attention, including any follow-up examinations which the examining physician determines to be necessary, under the following circumstances:

§1910.1450(g)(1)(i) - Whenever a worker develops signs or symptoms associated with a hazardous chemical to which the worker may have been exposed in the laboratory, the worker shall be provided an opportunity to receive an appropriate medical examination.

§1910.1450(g)(1)(ii) - Where exposure monitoring reveals an exposure level routinely above the action level (or in the absence of an action level, the PEL) for an OSHA regulated substance for which there are exposure monitoring and medical surveillance requirements, medical surveillance shall be established for the affected worker as prescribed by the particular standard.

§1910.1450(g)(1)(iii) - Whenever an event takes place in the work area such as a spill, leak, explosion or other occurrence resulting in the likelihood of a hazardous exposure, the affected worker shall be provided an opportunity for a medical consultation. Such consultation shall be for the purpose of determining the need for a medical examination.

§1910.1450(g)(2) - All medical examinations and consultations shall be performed by or under the direct supervision of a licensed physician and shall be provided without cost to the worker, without loss of pay and at a reasonable time and place.

Purpose:  The requirements specified by these paragraphs provide for medical attention under these circumstances to prevent the development of serious illnesses among workers overexposed or potentially overexposed to hazardous chemicals used in their work areas.

Information provided to the physician (§1910.1450(g)(3))

The employer shall provide the following information to the physician:

§1910.1450(g)(3)(i) - The identity of the hazardous chemical(s) to which the worker may have been exposed;

§1910.1450(g)(3)(ii) - A description of the conditions under which the exposure occurred including quantitative exposure data, if available; and

§1910.1450(g)(3)(iii) - A description of the signs and symptoms of exposure that the worker is experiencing, if any.

Purpose:  The examining physician is provided this information to assist him in evaluating the worker's exposure to a hazardous chemical.  The physician also uses this information to determine if an observed health condition is contributed to occupational exposure to hazardous chemicals in the laboratory work area.

Physician's written opinion (§1910.1450(g)(4))

§1910.1450(g)(4)(i) - For examination or consultation required under this standard, the employer shall obtain a written opinion from the examining physician which shall include the following:

      §1910.1450(g)(4)(i)(A) - Any recommendation for further medical follow-up;

      §1910.1450(g)(4)(i)(B) - The results of the medical examination and any associated tests;

      §1910.1450(g)(4)(i)(C) - Any medical condition which may be revealed in the course of the examination which may place the worker at increased risk as a result of exposure to a hazardous workplace; and

	§1910.1450(g)(4)(i)(D) - A statement that the worker has been informed by the physician of the results of the consultation or medical examination and any medical condition that may require further examination or treatment.

§1910.1450(g)(4)(ii) - The written opinion shall not reveal specific findings of diagnoses unrelated to occupational exposure.

Purpose:  The purpose of requiring the employer to obtain a physician's written opinion is to provide the employer with medical information on whether or not the worker has a condition indicating overexposure to hazardous chemicals.  If such a condition exists, the employer can implement additional controls to prevent overexposure.  The information also allows the employer to plan necessary medical follow-up and treatment.  The requirement that the physician's opinion be in writing ensures that the information is available for future reference.  Workers are given a copy of the physician's written opinion to determine the need for treatments and other interventions.  The written opinion allows the physician to make recommendations to remove the worker from the contaminated area or to make recommendations for control measures.

E.  Hazard Identification (§1910.1450(h))

§1910.1450(h)(1) - With respect to labels and material safety data sheets:

§1910.1450(h)(1)(i) - Employers shall ensure that labels on incoming containers of hazardous chemicals are not removed or defaced.

§1910.1450(h)(1)(ii) - Employers shall maintain any material safety data sheets that are received with incoming shipments of hazardous chemicals and ensure that they are readily accessible to laboratory workers.

§1910.1450(h)(2) - The following provisions shall apply to chemical substances developed in the laboratory:

§1910.1450(h)(2)(i) - If the composition of the chemical substance which is produced exclusively for the laboratory's use is known, the employer shall determine if it is a hazardous chemical as defined in paragraph (b) of this section. If the chemical is determined to be hazardous, the employer shall provide appropriate training as required under paragraph (f) of this section.

§1910.1450(h)(2)(ii) - If the chemical produced is a byproduct whose composition is not known, the employer shall assume that the substance is hazardous and shall implement paragraph (e) of this section.

§1910.1450(h)(2)(iii) - If the chemical substance is produced for another user outside of the laboratory, the employer shall comply with the Hazard Communication Standard (29 CFR 1910.1200) including the requirements for preparation of material safety data sheets and labeling.

Purpose:  The provision ensures that workers, whether in a laboratory facility or at a downstream facility, receive adequate notice and, if necessary, other information regarding chemicals that are hazardous or potentially hazardous.

OSHA believes that this provision protects workers by alerting them to potential hazardous chemical exposures, thereby allowing them to take appropriate actions to control these exposures.  In addition, this provision supplements the information and training requirements contained in paragraph (f) of the Standard.

F.  Use of Respirators (§1910.1450(i))

Where the use of respirators is necessary to maintain exposure below permissible exposure limits, the employer shall provide, at no cost to the worker, the proper respiratory equipment. Respirators shall be selected and used in accordance with the requirements of 29 CFR 1910.134.

Purpose:  The purpose of this requirement is to ensure that employers and workers select, use, and maintain appropriate respirators if respirators are necessary to protect workers from hazardous chemical exposures.

G.  Recordkeeping (§1910.1450(j))

§1910.1450(j)(1) - The employer shall establish and maintain for each worker an accurate record of any measurements taken to monitor worker exposures and any medical consultation and examinations including tests or written opinions required by this standard.

Purpose:  This requirement provides both employers and workers with useful information.  The information alerts employers to routine overexposures to hazardous chemicals, thereby, enabling them to modify controls or take other actions necessary to reduce these exposures.  The exposure monitoring and medical information contained in these records assists workers and their physicians in determining the need for, and effectiveness of, medical treatment and other interventions implemented in response to the workers' exposure to hazardous chemicals in a laboratory facility.

§1910.1450(j)(2) - The employer shall assure that such records are kept, transferred, and made available in accordance with 29 CFR 1910.1020.

Purpose:   Workers and their designated representatives may use these records to evaluate worker medical status over the course of employment, to determine the effectiveness of the employer's exposure reduction program, and for other reasons.  An OSHA compliance officer reviews the records to assess the employer's compliance with the medical and exposure control provisions of the Standard.

Paragraph (h) of §1910.1020 requires employers who cease to do business to transfer medical and exposure-monitoring records to the successor employer, who then must receive and maintain the records. This paragraph also requires that whenever an employer ceases to do business and there is no successor employer to receive and maintain the records subject to this standard, the 
employer shall notify affected current workers of their rights of access to records at least three (3) months prior to the cessation of the employer's business. OSHA considers the employer's 
transfer of records to a successor to be usual and customary communications during the transition from one employer to a successor employer.  In this regard, the employer would communicate the location of all records, including worker exposure-monitoring and medical records, at the facility to the successor employer during the transfer of business operations, as a matter of usual and customary business practice.  In addition, OSHA accounts for the burden hours and costs resulting from the worker notification requirements under the Information 
Collection Request (ICR) for its Access to Worker Exposure and Medical Records Standard (§ 1910.1020), OMB Control No. 1218-0065.

3.  	Describe whether, and to what extent, the collection of information involves the use of automated, electronic, mechanical, or other technological collection techniques or other forms of information technology, e.g., permitting electronic submission of responses, and the basis for the decision for adopting this means of collection.  Also describe any consideration of using information technology to reduce burden.

Employers may use any available technology to meet the paperwork requirements specified by the Standard.  The Agency wrote these provisions in performance-oriented language, i.e., in terms of what information to provide, not how to provide it.

4.  	Describe efforts to identify duplication.  Show specifically why any similar information already available cannot be used or modified for use for the purposes described in Item A.2. above.

The information collection requirements in the Standard are specific to each employer involved, and no other sources or agencies duplicate these requirements or can make the required information available to OSHA, i.e., the required information is available only from employers.

5.  	If the collection of information impacts small businesses or other small entities, describe any methods used to minimize burden.

The information collection requirements specified by the Standard do not have a significant impact on a substantial number of small entities.

6.		Describe the consequence to Federal program or policy activities if the collection is not conducted or is conducted less frequently, as well as any technical or legal obstacles to reducing burden.

The Agency believes that the information collection frequencies required by the Standard are the minimum frequencies necessary to fulfill its mandate "to assure so far as possible every working man and woman in the Nation safe and healthful working conditions and to preserve our human resources" as specified in the OSH Act at 29 U.S.C. 651.  Accordingly, if employers do not perform the information collections required by the Standard, or delay in providing this information, workers are at risk of developing serious illnesses resulting from overexposure to hazardous chemicals used in laboratory facilities.

7.  	Explain any special circumstances that would cause an information collection to be conducted in a manner:

       · requiring respondents to report information to the agency more often than quarterly;
     	
      · requiring respondents to prepare a written response to a collection of information in fewer than 30 days after receipt of it;

      · requiring respondents to submit more than an original and two copies of any document;

      · requiring respondents to retain records, other than health, medical, government contract, grant-in-aid, or tax records for more than three years;

      · in connection with a statistical survey, that is not designed to produce valid and reliable results that can be generalized to the universe of study;

      · requiring the use of a statistical data classification that has not been reviewed and approved by OMB;

      ·  that includes a pledge of confidentiality that is not supported by authority established in statute or regulation, that is not supported by disclosure and data security policies that are consistent with the pledge, or which unnecessarily impedes sharing of data with other agencies for compatible confidential use; or

      ·  requiring respondents to submit proprietary trade secret, or other confidential information unless the agency can demonstrate that it has instituted procedures to protect the information's confidentiality to the extent permitted by law.

Paragraph (d)(4) of the Standard requires that employers notify each worker of their exposure monitoring results within 15 working days after receiving these results.  Employers may notify workers either individually in writing or by posting the monitoring results in an appropriate location that is accessible to the workers.  Except for this provision, the information collection requirements of the Standard are consistent with 5 CFR 1320.5.

8.	If applicable, provide a copy and identify the date and page number of publication in the Federal Register of the agency's notice, required by 5 CFR 1320.8(d), soliciting comments on the information collection prior to submission to OMB.  Summarize public comments received in response to that notice and describe actions taken by the agency in response to these comments.  Specifically address comments received on cost and hour burden.

      	Describe efforts to consult with persons outside the agency to obtain their views on the availability of data, frequency of collection, the clarity of instructions and recordkeeping, disclosure, or reporting format (if any), and on the data elements to be recorded, disclosed, or reported.

     	Consultation with representatives of those from whom information is to be obtained or those who must compile records should occur at least once every 3 years, even if the collection of information activity is the same as in prior periods.  There may be circumstances that may preclude consultation in a specific situation.  These circumstances should be explained.


As required by the Paperwork Reduction Act of 1995 (PRA) (44 U.S.C. 506(c)(2)(A)), OSHA published a notice in the Federal Register on March 28, 2022 (87 FR 17337) (Docket No. OSHA-2011-0059) soliciting comments on its proposal to extend the Office of Management and Budget's (OMB) approval of the information collection requirements specified in the Occupational Exposure to Hazardous Chemicals in Laboratories Standard (29 CFR 1910.1450). This notice is part of a preclearance consultation program that provides interested parties the opportunity to comment on OSHA's request for an extension by OMB of a previous approval of the information collection requirements found in the above Standard. The Agency will respond to any substantive comments submitted in response to this notice

9.		Explain any decision to provide any payment or gift to respondents, other than renumeration of contractors or grantees.

The Agency will not provide payments or gifts to the respondents.

 Describe any assurance of confidentiality provided to respondents and the basis for
	the assurance in statute, regulation, or agency policy.

To ensure that the personal information in the medical records required by the Standard remains confidential, the Agency developed §1913.10 ("Rules of Agency Practice and Procedure Concerning OSHA Access to Worker Medical Records") to regulate its access to these records.

11.	Provide additional justification for any question of a sensitive nature, such as sexual behavior and attitudes, religious beliefs, and other matters that are commonly considered private.  This justification should include the reasons why the agency considers the questions necessary, the specific uses to be made of the information, the explanation to be given to persons from whom the information is requested, and any steps to be taken to obtain their consent.

The paperwork requirements specified by the Standard do not involve sensitive information.

12.	Provide estimates of the hour burden of the collection of information.  The statement should:

     	·   Indicate the number of respondents, frequency of response, annual hour burden, and an explanation of how the burden was estimated.  Unless directed to do so, agencies should not conduct special surveys to obtain information on which to base hour burden estimates.   

				Consultation with a sample (fewer than 10) of potential respondents is desirable.  If the hour burden on respondents is expected to vary widely because of differences in activity, size, or complexity, show the range of estimated hour burden, and explain the reasons for the variance. Generally, estimates should not include burden hours for customary and usual business practices.

     	  	 ·   If this request for approval covers more than one form, provide separate hour burden estimates for each form and aggregate the hour burdens.

           ·    Provide estimates of annualized cost to respondents for the hour burdens for collections of information, identifying and using appropriate wage-rate categories.
         
Table 1 below presents information for the different types of laboratories covered by the Standard. For each type of laboratory, the table provides an estimate of the number of facilities that expose workers to hazardous chemicals and the number of workers so exposed.


Table 1. Number of Laboratory Facilities and Workers for Each Type of Laboratory
Type of Laboratory
No. of Facilities
No. of Workers
Industrial
 
 
   Independent testing[a]
7,137
144,053
   Research and development[b]
62,837
1,766,000
Subtotals
                69,974
                                        1,910,053
Clinical
 
 
   Hospital[c]
14,386
326,220
   Independent-medical[d]
11,932
193,907
Subtotals
                26,318
                                           520,127
Academic (Private)
 
 
   Post-secondary[e]
3,895
157,528
   Secondary[f]
51,444
239,940
   Professional and Research Institutes[g]
17,557
244,147
Subtotals
                72,896
                                           641,615
Totals
              169,188
                                       3,071,795
              
      [[a]]Source: County Business Patterns (CBP), 2019. County Business Patterns (CBP), 2019. County Business Patterns (CBP). US Census. Available at http://www.census.gov/econ/cbp/download/ (Accessed January 6, 2022).The number of Testing Laboratories (ITLs) and workers in those ITLs is assumed to be equal to the number of establishments and the number of employees in NAICS 541380 Testing Laboratories.  
              
      [[b]]Source: National Science Foundation (NSF), 2018. Business Research and Development and Innovation - 2014. National Center for Science and Engineering Statistics (NCSES). Available at: https://ncses.nsf.gov/pubs/nsf21312#data-tables. TABLE 4. Companies with worldwide, domestic, and foreign R&D paid for by the company and by others and performed by the company, by source of funds, industry, and company size: 2014; TABLE 47. Worldwide, domestic, and foreign total and R&D employment, by industry and company size: 2014. The number of employees was taken from Table 53.

      [[c]]Source: Bureau of Labor and Statistics (BLS), 2020. Bureau of Labor and Statistics (BLS), 2020. Occupational Employment Statistics (OES) - National, May 2017. Available at https://www.bls.gov/oes/tables.htm. 
The number of employees in Occupational Codes 29-2010 Clinical Laboratory Technologists and Technicians (326,220) was used to estimate the number of workers in the hospital-based labs. The percent change in employees from the previous ICR (322,380) to 326,220 (161,710 + 160,460) in 2017 was 0.07 percent which was then applied to the number of hospital labs from the previous ICR (14,210) to obtain 14,386 (14,210 * (1 + 0.07%). 
      
       [[d]] County Business Patterns (CBP), 2019. County Business Patterns (CBP), 2019. County Business Patterns (CBP). US Census. Available at https://www.census.gov/programs-surveys/cbp/data/tables.html . The number of establishments and employees in NAICS 621511 Medical Laboratories were used to estimate the number of Independent-Medical facilities and the number of workers there respectively.
      
      [[e]] Source: National Center For Education Statistics (NCES), 2017. National Center For Education Statistics (NCES), 2017. Table 305.30. Number and percentage of degree-granting postsecondary institutions with first-year undergraduates using various selection criteria for admission, by control and level of institution: Selected years, 2000-01 through 2016-17. Digest of Education Statistics. Available at https://nces.ed.gov/programs/digest/d17/tables/dt17_305.30.asp (Accessed June 15, 2018). 
Used the number of degree-granting postsecondary institutions (3,897) to estimate the number of facilities in post-secondary labs. That was a 9.3 percent decrease from the estimate from the previous ICR (4,294). The 9.3 percent decreased was applied to the previous number of workers in post-secondary labs (173,665) which resulted in 157,528 workers. (This footnote will be updated during the 60 day comment period).

      [[f]]Source: National Center For Education Statistics (NCES), 2017 National Center For Education Statistics (NCES), 2017a. Table 214.40. Public elementary and secondary school enrollment, number of schools, and other selected characteristics, by locale: Fall 2012 through fall 2015. Digest of Education Statistics. Available at https://nces.ed.gov/programs/digest/d17/tables/dt17_214.40.asp (Accessed June 15, 2018). National Center For Education Statistics (NCES), 2013. Table 205.50. Private elementary and secondary enrollment, number of schools, and average tuition, by school level, orientation, and tuition- Selected years, 1999 - 2000 through 2011-12. Digest of Education Statistics. Available at https://nces.ed.gov/programs/digest/d13/tables/dt13_205.50.asp (Accessed June 23, 2015). Fast Facts: Educational institutions (84)
According to NCES, 2018-19, there was a total of 98.469public elementary and secondary schools. In order to obtain the updated number of secondary schools, the agency multiplied this number by 52.4 percent (which is the percentage of secondary school enrollment as a percent of total school enrollment (NCES, 2013). Could not update as more recent data was not found. (This footnote will be updated during the 60 day comment period.)

      [[g]]Source: County Business Patterns (CBP), 2019. County Business Patterns (CBP). U.S. Census. Available at https://www.census.gov/programs-surveys/cbp/data/data sets.html.  For this ICR, the NAICS 541713 Research and Development in Nanotechnology , 541714  Research and Development(except Nanotechnology, and for NAICS 541715 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology). The NAICS codes have been  updated.  The two values are being added together, and then extrapolated based on the change between that and the sum of the new NAICS codes. This is different from the old method where we extrapolated both NAICS codes individually. 



Burden Hour and Cost Determinations

The Agency determined the wage rate from mean hourly wage earnings to represent the cost of employee time.  For the relevant standard occupational classification category, OSHA used the wage rates reported in the Bureau of Labor Statistics, U.S. Department of Labor.  Occupational Employment and Wage Statistics (OEWS), May 2020 [date accessed: December 22, 2021].  (OEWS data is available at https://www.bls.gov/oes/tables.htm.  To access a wage rate, select the year, "Occupation Profiles," and the Standard Occupational Classification (SOC) code.)

To account for fringe benefits, the Agency used the Bureau of Labor Statistics' (BLS) Occupational Employment and Wage Statistics (OEWS) (2020).  Fringe markup is from the following BLS release: Employer Costs for Employee Compensation news release text; released 10:00 AM (EDT), December 17, 2021 (Employer Costs for Employee Compensation News Release - 2021 Q03 Results (bls.gov)). BLS reported that for civilian workers, fringe benefits accounted for 29.2 percent of total compensation and wages accounted for the remaining 70.8 percent.  To calculate the loaded hourly wage for each occupation, the Agency divided the mean hourly wage rate by 1 minus the fringe benefits. 

Table 1- Estimated Wage Rates
WAGE HOUR ESTIMATES FOR CHEMICAL MANUFACTURING
Occupational Title
Standard Occupation Code
Mean Hourly Wage Rate
(A)
Fringe Benefits 

(B)
Loaded Hourly Wage Rate 
(C) = (A)/((1-(B))
Administrative Service Manager
11-3010
$51.98
29.2%
$73.42
Worker (Chem. Tech)
19-4031
$25.82
29.2%
$36.47
Office & Administrative Support Occupations 
43-0000
$20.38
29.2%
$28.79

			Administrative Service Manager        $73.42
			Worker                                            	$36.47
                        	Office Clerk                                        $28.79

(A)  Worker exposure determination (§1910.1450(d))

Initial monitoring (§1910.1450(d)(1)) and periodic monitoring (§1910.1450(d)(2) and (d)(3))

As noted above in Item 1, laboratory workers typically use small quantities of numerous hazardous chemicals in a variety of procedures and operations, each of which they perform infrequently or periodically. In addition, standard laboratory practices require techniques that control the release of, and exposure to, hazardous chemicals (e.g., extensive labeling, sealed containers, protective clothing such a gloves and goggles, laboratory hoods). Therefore, overexposure of laboratory workers to hazardous chemicals is rare. Accordingly, OSHA assumes that only a minimal need exists to conduct initial and periodic exposure monitoring (i.e., once a year per laboratory facility), and that a laboratory supervisor takes, on average, 10 minutes (10/60 hour) to distribute and collect exposure-monitoring samples and mail them for analysis. Thus, the estimated burden hours and cost for these requirements each year are:
      
      Burden hours: 169,188 facilities x 10/60 hour = 28,198 hours
  			   Cost: 28,198 hours x $73.42= $2,070,297.16

Worker notification of monitoring results (§1910.1450(d)(4))

Assuming that employers post exposure monitoring results in an appropriate location, the Agency estimates that an office clerk spends five minutes (5/60 hour) developing and posting 
these results for each facility once a year. Therefore, the estimated annual burden hours and cost of this provision are:

      Burden hours:	169,188 facilities x 5/60 hour = 14,099 hours
               Cost:	14,099 hours x $28.79 = $405,910.21
             
(B)  Chemical hygiene plan (§1910.1450(C))

This paragraph requires new laboratory facilities to develop a chemical hygiene plan (CHP), while existing facilities must review their CHPs at least annually. The Agency estimates that the number of laboratory facilities increased by 25,517, annually during the past three years (169,188 existing CHPs  -  64,404 CHPs =104,784/3 = 34,928 and that a laboratory supervisor (acting as the Chemical Hygiene Officer) takes 8 hours to develop a new CHP and one-half hour to update an existing CHP. The burden hour and cost estimate for this requirement are:

             Burden hours: [(34,928 new CHPs x 8 hours) = 279,424] + [(169,188 existing
                           CHPs x 30/60 = 84,594 hours)] = 364,018 hours
             Cost:	  364,018 hours x $73.42 = $26,726,201.56
            
(C)  Worker information and training (§1910.1450(f))

Upon further analysis, the requirements that employers provide training to workers under paragraphs (f)(1) through (f)(4), are not considered to be collections of information. OSHA is not taking burden for these activities under Item 12 of this Supporting Statement.

(D)  Medical consultation and medical examinations (§1910.1450(g))

General (§1910.1450(g)(1) and (g)(2))

OSHA believes that 8% (245,744 of the workers covered by the Standard receive medical attention. Of these workers, the Agency assumes that: half (122,872) obtain a medical consultation, which OSHA estimates takes 45 minutes (45/60 hour) to administer; one-fourth (61,436 receive a medical examination, which the Agency finds takes 1.5 hours to administer; and the remaining one-fourth get both a medical consultation and medical examination, requiring an estimated total of 2.25 hours to administer. Thus, the estimated annual burden hour and cost to employers of the lost productivity resulting from these provisions a

		Burden hours: [(122,872 workers x 45/60 hour) = 92,154] 
                          [(61,436 workers x 90/60 = 92,154 hours
                      +  [(61,436 workers x 135/60 hours)] = 138,231  hours
                          = 322,539 hours

	Cost:	322,539 hours x $36.47 = $ 11,762,997.33
            
Information provided to the physician (§1910.1450(g)(3))

OSHA estimates that an office clerk spends five minutes (5/60 hour) compiling and sending the required information to the physician prior to each medical consultation or medical examination. Therefore, the yearly burden hour and cost estimates for this paperwork requirement are:

      Burden hours: 245,744 x 5/60 hour = 20,479 hours
              Cost:	20,479 hours x $28.79 = $589,590.41

Physician's written opinion (§1910.1450(g)(4))

The Agency assumes that the physician writes an opinion for each medical consultation and medical examination administered (for a total of written opinions annually), and that an office clerk takes five minutes (5/60 hour) to distribute the written opinion to a worker. Thus, the estimated burden hours and cost of this requirement each year are:

      Burden hours: 245,744 written opinions x 5/60 hour =20,479 hours
               Cost:	20,479 hours x $28.79 = $589,590.41
            
(E)  Hazard identification (§1910.1450(h))

OSHA's Hazard Communication (HC) Standard (§1910.1200) applies to the requirements regarding labels and Safety Data Sheets specified by this provision of the Standard. Therefore, 
the Agency is accounting for the burden hours and cost resulting from these requirements under the Information Collection Request (ICR) for the HC Standard, OMB Control Number 1218-0072.

(F)  Use of respirators (§1910.1450(i))

The Agency accounts for the burden hours and cost resulting from this paragraph (including the selection, use, and maintenance of respirators, and the development of a written respirator 
protection program) under the Information Collection Request (ICR) for OSHA's Respiratory Protection Standard (§1910.134), OMB Control Number 1218-0099.

(G)  Recordkeeping (§1910.1450(j))

General (§1910.1450(j)(1))

As noted above in section (A) ("Exposure Monitoring") of this item, each laboratory facility covered by the Standard develops a record of exposure monitoring results, for an annual total of 169,188 records.  In addition, the determinations made above in section (D) ("Medical Consultation and Medical Examinations") show that employers administer 245,744 medical consultations and medical examinations annually, developing 245,7443 medical records. Under the requirements of this recordkeeping provision, the Agency estimates that an office clerk spends five minutes each year establishing and maintaining each of these records. Therefore, the annual burden hours and cost associated with this recordkeeping requirement are:

           Burden hours: [(169,188 exposure monitoring records) + (245,744 medical records)] x 5/60 hour = 34,578 hours
             Cost:	 34,578 hours x $28.79 = $995,500.62

Worker access

For this determination, OSHA estimates that the exposure monitoring requirements of the Standard cover all workers 3,071,795 in laboratory facilities, while 245,744 of these workers  have medical records (see previous determinations in this section). Additionally, the Agency assumes that 10% (426,686 of the workers covered by these records request access to them each year (3,071,795 workers + 245,744 workers) x 10% = 331,754 workers). OSHA estimates that an office clerk takes five minutes (5/60 hour) to retrieve and re-file each requested record, resulting in the following annual burden hour and cost estimates:

      Burden hours: 331,754 workers x 5/60 hours = 27,646 hours
             Cost:  27,646 hours x $28.79 = $795,928.34
            
      

      
Table 2: Estimated Annualized Respondent Hour and Cost Burden Table
Information Collection Requirement

Type of Respondent*
No. of
Respondents
No. of Responses per Respondent
Total No.  of Responses
Avg.
Burden per Response (In Hrs.)
Total Burden Hours 
Avg.  Hourly Wage Rate
Total Burden Costs 
 A. Worker exposure determination (§1910.1450(d))

Initial monitoring and periodic monitoring
Administrative Service Manager
169,188
1
169,188
10/60
28,198
$73.42
$2,070,297.16
Worker notification of monitoring results
Office Clerk
169,188
1
169,188
5/60
14,099
$28.79
$405,910.21
Unduplicated Totals

--
--
338,376
--
42,297
--
$2,476,207.37
B. Chemical hygiene plan (§1910.1450(e))

Administrative Service Manager
169,188
0.206445
34,928
8
279,424
$73.42
$20,515,310.08

Administrative Service Manager
169,188
1
    169,188
30/60
84,594
$73.42
$6,210,891.48
Unduplicated Totals

--
--
204,116
--
364,018
--
$26,726,201.56
C. Worker information and training (§1910.1450(f))
D. Medical consultation and medical examinations (§1910.1450(g))
General
Worker (Chem. Tech)
169,188,
0.726245
    122,872
45/60
92,154
$36.47
$3,360,856.38

Worker (Chem. Tech)
169,188
    0.363122
            61,436
90/60
92,154
$36.47
$3,360,856.38

Worker (Chem. Tech)
169,18
.46703
61,436
135/60
   138,231
$36.47
$5,041,284.57
Information provided to the physician
Office Clerk
169,188
1.452490
245,744
5/60
   20,479
$28.79
$589,590.41
Physician's written opinion
Office Clerk
169,188
1.452490
245,744
5/60
20,479
$28.79
$589,590.41
Unduplicated Totals

--
--
737,232
--
   363,497
--
$12,942,178.15
E. Hazard identification (§1910.1450(h))
F. Use of respirators (§1910.1450(i))
G. Recordkeeping (§1910.1450(j))
General
Office Clerk
169,188
2.452490
414,932
5/60
34,578
$28.79
$995,500.62
Worker Access to records
Office Clerk
169,188
1.96086
    331,754
5/60
    27,646
$28.79
$795,928.34
Unduplicated Totals

--
--
746,686
--
    62,224
--
$1,791,428.96
GRAND TOTALS

--
--
2,026,410
--
   832,036                                 
--
$43,936,016.04
            
*NOTE: Respondents are private sector establishments -- business or other for profit.
Wage category provided for estimating cost burden.



13.  	Provide an estimate of the total annual cost burden to respondents or recordkeepers resulting from the collection of information.  (Do not include the cost of any hour burden shown in Items 12 and 14).

     	. The cost estimate should be split into two components: (a) a total capital and start-up cost component (annualized over its expected useful life); and (b) a total operation and maintenance and purchase of service component.  The estimates should take into account costs associated with generating, maintaining, and disclosing or providing the information.  Include descriptions of methods used to estimate major cost factors including system and technology acquisition, expected useful life of capital equipment, the discount rate(s), and the time period over which costs will be incurred.  Capital and start-up costs include, among other items, preparations for collecting information such as purchasing computers and software; monitoring, sampling, drilling and testing equipment; and record storage facilities.

 	·  If cost estimates are expected to vary widely, agencies should present ranges of cost burdens and explain the reasons for the variance.  The cost of purchasing or contracting out information collection services should be a part of this cost burden estimate.  In developing cost burden estimates, agencies may consult with a sample of respondent (fewer than 10), utilize the 60-day pre-OMB submission public comment process and use existing economic or regulatory impact analysis associated with the rulemaking containing the information collection, as appropriate.

 	·  Generally, estimates should not include purchases of equipment or services, or portions thereof, made: (1) prior to October 1, 1995, (2) to achieve regulatory compliance with requirements not associated with the information collection, (3) for reasons other than to provide information or keep records for the government, or (4) as part of customary and usual business or private practices.

Capital Cost Determinations

Annual Medical Cost Determinations

OSHA found that the annual cost of providing workers with exposure monitoring, medical consultations, and medical examinations is $94,198,596. The following sections describe the cost determinations.

 (A)  Exposure monitoring


The Agency estimates that employers pay $72 to analyze an exposure monitoring sample. According to the information provided above in section (A) ("Exposure Monitoring") under Item 12, employers collect 169,188 exposure monitoring samples each year. Thus, the annual cost associated with obtaining exposure monitoring samples is:

      Cost:	169,188 samples x $72 = $12,181,536

 (B)  Medical consultation and medical examinations

OSHA identified the following costs for providing medical attention to workers: Medical consultation (med consult), $177; medical examination (med exam), $402; and a combined medical consultation and med examination (med consult-med exam), $579. In addition, the determinations made above in section (D) ("Medical consultation and medical examinations") show that each year employers administer 122,872 med consults, 61,436 med exams, and 61,436 med consults-med exams to workers. Accordingly, the yearly cost of providing medical attention to workers is:

            Cost:	[(122,872 med consults x $177) = $21,748,344] + [(61,436 med exams x $402) = $24,697,272] + [(61,436 med consults-med exams x $579 = $35,571,444)] = $82,017,060

14.  	Provide estimates of annualized cost of the Federal government.  Also, provide a description of the method used to estimate cost, which should include quantification of hours, operational expenses (such as equipment, overhead, printing, and support staff) and any other expense that would not have been incurred without this collection of information.  Agencies also may aggregate cost estimates from Items 12, 13 and 14 in a single table.

There is no cost to the Federal Government associated with this information collection request.

15.  	Explain the reasons for any program changes or adjustments.

OSHA is requesting an adjustment increase in the existing burden hour estimate for the collection of information requirements in the Standard.  In this regard, the Agency is requesting to increase the current burden hour estimate from 695,105 to 832,036 hours, a total adjustment of 136,931 hours.  The adjustment is due to an increase in the worker and establishment estimates for this ICR. Additionally, the capital cost estimate has increased from $79,770,481 to $94,198,596 total increase of $14,428,115.  This increase is a result of an increase in the number of workers requiring medical consultations and medical examinations. 

16. 	For collections of information whose results will be published, outline plans for tabulation, and publication.  Address any complex analytical techniques that will be used.  Provide the time schedule for the entire project, including beginning and ending dates of the collection information, completion of report, publication dates, and other actions.

OSHA will not publish the information collected under the Standard.

17.  	If seeking approval to not display the expiration date for OMB approval of the information collection, explain the reasons that display would be appropriate.

OSHA lists current valid control numbers in §§1910.8, 1915.8, 1917.4, 1918.4 and 1926.5 and publishes the expiration date in the Federal Register notice announcing OMB approval of the information collection requirement.  (5 CFR 1320.3(f)(3)).   OSHA believes that this is the most appropriate and accurate mechanism to inform interested parties of these expiration dates.

18.  	Explain each exception to the certification statement.

OSHA is not requesting an exception to the certification statement.

B. COLLECTIONS OF INFORMATON EMPLOYING STATISTICAL METHODS

This Supporting Statement does not contain any collection of information requirements that employ statistical methods.




















SEC. 2. Congressional Findings and Purpose
(a) The Congress finds that personal injuries and illnesses arising out of work situations impose a substantial burden upon, and are a hindrance to, interstate commerce in terms of lost production, wage loss, medical expenses, and disability compensation payments. (b) The Congress declares it to be its purpose and policy, through the exercise of its powers to regulate commerce among the several States and with foreign nations and to provide for the general welfare, to assure so far as possible every working man and woman in the Nation safe and healthful working conditions and to preserve our human resources --
29 USC 651
(1) by encouraging employers and employees in their efforts to reduce the number of occupational safety and health hazards at their places of employment, and to stimulate employers and employees to institute new and to perfect existing programs for providing safe and healthful working conditions; (2) by providing that employers and employees have separate but dependent responsibilities and rights with respect to achieving safe and healthful working conditions; (3) by authorizing the Secretary of Labor to set mandatory occupational safety and health standards applicable to businesses affecting interstate commerce, and by creating an Occupational Safety and Health Review Commission for carrying out adjudicatory functions under the Act; (4) by building upon advances already made through employer and employee initiative for providing safe and healthful working conditions; (5) by providing for research in the field of occupational safety and health, including the psychological factors involved, and by developing innovative methods, techniques, and approaches for dealing with occupational safety and health problems; (6) by exploring ways to discover latent diseases, establishing causal connections between diseases and work in environmental conditions, and conducting other research relating to health problems, in recognition of the fact that occupational health standards present problems often different from those involved in occupational safety; (7) by providing medical criteria which will assure insofar as practicable that no employee will suffer diminished health, functional capacity, or life expectancy as a result of his work experience; (8) by providing for training programs to increase the number and competence of personnel engaged in the field of occupational safety and health; affecting the OSH Act since its passage in 1970 through January 1, 2004. (9) by providing for the development and promulgation of occupational safety and health standards; (10) by providing an effective enforcement program which shall include a prohibition against giving advance notice of any inspection and sanctions for any individual violating this prohibition;
(11) by encouraging the States to assume the fullest responsibility for the administration and enforcement of their occupational safety and health laws by providing grants to the States to assist in identifying their needs and responsibilities in the area of occupational safety and health, to develop plans in accordance with the provisions of this Act, to improve the administration and enforcement of State occupational safety and health laws, and to conduct experimental and demonstration projects in connection therewith; (12) by providing for appropriate reporting procedures with respect to occupational safety and health which procedures will help achieve the objectives of this Act and accurately describe the nature of the occupational safety and health problem; (13) by encouraging joint labor-management efforts to reduce injuries and disease arising out of employment.



6. Occupational Safety and Health Standards 
29 USC 655: 
(a) Without regard to chapter 5 of title 5, United States Code, or to the other subsections of this section, the Secretary shall, as soon as practicable during the period beginning with the effective date of this Act and ending two years after such date, by rule promulgate as an occupational safety or health standard any national consensus standard, and any established Federal standard, unless he determines that the promulgation of such a standard would not result in improved safety or health for specifically designated employees. In the event of conflict among any such standards, the Secretary shall promulgate the standard which assures the greatest protection of the safety or health of the affected employees. (b) The Secretary may by rule promulgate, modify, or revoke any occupational safety or health standard in the following manner: 
(1) Whenever the Secretary, upon the basis of information submitted to him in writing by an interested person, a representative of any organization of employers or employees, a nationally recognized standards-producing organization, the Secretary of Health and Human Services, the National Institute for Occupational Safety and Health, or a State or political subdivision, or on the basis of information developed by the Secretary or otherwise available to him, determines that a rule should be promulgated in order to serve the objectives of this Act, the Secretary may request the recommendations of an advisory committee appointed under section 7 of this Act. The Secretary shall provide such an advisory committee with any proposals of his own or of the Secretary of Health and Human Services, together with all pertinent factual information developed by the Secretary or the Secretary of Health and Human Services, or otherwise available, including the results of research, demonstrations, and experiments. An advisory committee shall submit to the Secretary its recommendations regarding the rule to be promulgated within ninety days from the date of its appointment or within such longer or shorter period as may be prescribed by the Secretary, but in no event for a period which is longer than two hundred and seventy days. (2) The Secretary shall publish a proposed rule promulgating, modifying, or revoking an occupational safety or health standard in the Federal Register and shall afford interested persons a period of thirty days after publication to submit written data or comments. Where an advisory committee is appointed and the Secretary determines that a rule should be issued, he shall publish the proposed rule within sixty days after the submission of the advisory committee's recommendations or the expiration of the period prescribed by the Secretary for such submission. (3) On or before the last day of the period provided for the submission of written data or comments under paragraph (2), any interested person may file with the Secretary written objections to the proposed rule, stating the grounds therefore and requesting a public hearing on such objections. Within thirty days after the last day for filing such objections, the Secretary shall publish in the Federal Register a notice specifying the occupational safety or health standard to which objections have been filed and a hearing requested, and specifying a time and place for such hearing. 








SEC. 8. Inspections, Investigations, and Recordkeeping
(a) In order to carry out the purposes of this Act, the Secretary, upon presenting appropriate credentials to the owner, operator, or agent in charge, is authorized --
29 USC 657
 
(1) to enter without delay and at reasonable times any factory, plant, establishment, construction site, or other area, workplace or environment where work is performed by an employee of an employer; and

(2) to inspect and investigate during regular working hours and at other reasonable times, and within reasonable limits and in a reasonable manner, any such place of employment and all pertinent conditions, structures, machines, apparatus, devices, equipment, and materials therein, and to question privately any such employer, owner, operator, agent or employee.

(b) In making his inspections and investigations under this Act the Secretary may require the attendance and testimony of witnesses and the production of evidence under oath. Witnesses shall be paid the same fees and mileage that are paid witnesses in the courts of the United States. In case of a contumacy, failure, or refusal of any person to obey such an order, any district court of the United States or the United States courts of any territory or possession, within the jurisdiction of which such person is found, or resides or transacts business, upon the application by the Secretary, shall have jurisdiction to issue to such person an order requiring such person to appear to produce evidence if, as, and when so ordered, and to give testimony relating to the matter under investigation or in question, and any failure to obey such order of the court may be punished by said court as a contempt thereof.

(c) (1) Each employer shall make, keep and preserve, and make available to the Secretary or the Secretary of Health and Human Services, such records regarding his activities relating to this Act as the Secretary, in cooperation with the Secretary of Health and Human Services, may prescribe by regulation as necessary or appropriate for the enforcement of this Act or for developing information regarding the causes and prevention of occupational accidents and illnesses. In order to carry out the provisions of this paragraph such regulations may include provisions requiring employers to conduct periodic inspections. The Secretary shall also issue regulations requiring that employers, through posting of notices or other appropriate means, keep their employees informed of their protections and obligations under this Act, including the provisions of applicable standards.

 
(2) The Secretary, in cooperation with the Secretary of Health and Human Services, shall prescribe regulations requiring employers to maintain accurate records of, and to make periodic reports on, work-related deaths, injuries and illnesses other than minor injuries requiring only first aid treatment and which do not involve medical treatment, loss of consciousness, restriction of work or motion, or transfer to another job.

(3) The Secretary, in cooperation with the Secretary of Health and Human Services, shall issue regulations requiring employers to maintain accurate records of employee exposures to potentially toxic materials or harmful physical agents which are required to be monitored or measured under section 6. Such regulations shall provide employees or their representatives with an opportunity to observe such monitoring or measuring, and to have access to the records thereof. Such regulations shall also make appropriate provision for each employee or former employee to have access to such records as will indicate his own exposure to toxic materials or harmful physical agents. Each employer shall promptly notify any employee who has been or is being exposed to toxic materials or harmful physical agents in concentrations or at levels which exceed those prescribed by an applicable occupational safety and health standard promulgated under section 6, and shall inform any employee who is being thus exposed of the corrective action being taken.

(d) Any information obtained by the Secretary, the Secretary of Health and Human Services, or a State agency under this Act shall be obtained with a minimum burden upon employers, especially those operating small businesses. Unnecessary duplication of efforts in obtaining information shall be reduced to the maximum extent feasible.

(e) Subject to regulations issued by the Secretary, a representative of the employer and a representative authorized by his employees shall be given an opportunity to accompany the Secretary or his authorized representative during the physical inspection of any workplace under subsection (a) for the purpose of aiding such inspection. Where there is no authorized employee representative, the Secretary or his authorized representative shall consult with a reasonable number of employees concerning matters of health and safety in the workplace.

(f) (1) Any employees or representative of employees who believe that a violation of a safety or health standard exists that threatens physical harm, or that an imminent danger exists, may request an inspection by giving notice to the Secretary or his authorized representative of such violation or danger. Any such notice shall be reduced to writing, shall set forth with reasonable particularity the grounds for the notice, and shall be signed by the employees or representative of employees, and a copy shall be provided the employer or his agent no later than at the time of inspection, except that, upon the request of the person giving such notice, his name and the names of individual employees referred to therein shall not appear in such copy or on any record published, released, or made available pursuant to subsection (g) of this section. If upon receipt of such notification the Secretary determines there are reasonable grounds to believe that such violation or danger exists, he shall make a special inspection in accordance with the provisions of this section as soon as practicable, to determine if such violation or danger exists. If the Secretary determines there are no reasonable grounds to believe that a violation or danger exists he shall notify the employees or representative of the employees in writing of such determination.

 
(2) Prior to or during any inspection of a workplace, any employees or representative of employees employed in such workplace may notify the Secretary or any representative of the Secretary responsible for conducting the inspection, in writing, of any violation of this Act which they have reason to believe exists in such workplace. The Secretary shall, by regulation, establish procedures for informal review of any refusal by a representative of the Secretary to issue a citation with respect to any such alleged violation and shall furnish the employees or representative of employees requesting such review a written statement of the reasons for the Secretary's final disposition of the case.

(g) (1) The Secretary and Secretary of Health and Human Services are authorized to compile, analyze, and publish, either in summary or detailed form, all reports or information obtained under this section.

 
(2) The Secretary and the Secretary of Health and Human Services shall each prescribe such rules and regulations as he may deem necessary to carry out their responsibilities under this Act, including rules and regulations dealing with the inspection of an employer's establishment.

(h) The Secretary shall not use the results of enforcement activities, such as the number of citations issued or penalties assessed, to evaluate employees directly involved in enforcement activities under this Act or to impose quotas or goals with regard to the results of such activities.
Pub. L. 105-198 added subsection (h).


§ 1910.1450 Occupational exposure to hazardous chemicals in laboratories.
  (a) Scope and application. 
   (1) This section shall apply to all employers engaged in the laboratory use of hazardous chemicals as defined below. 
   (2) Where this section applies, it shall supersede, for laboratories, the requirements of all other OSHA health standards in 29 CFR part 1910, subpart Z, except as follows: 
     (i) For any OSHA health standard, only the requirement to limit employee exposure to the specific permissible exposure limit shall apply for laboratories, unless that particular standard states otherwise or unless the conditions of paragraph (a)(2)(iii) of this section apply. 
     (ii) Prohibition of eye and skin contact where specified by any OSHA health standard shall be observed. 
     (iii) Where the action level (or in the absence of an action level, the permissible exposure limit) is routinely exceeded for an OSHA regulated substance with exposure monitoring and medical surveillance requirements, paragraphs (d) and (g)(1)(ii) of this section shall apply. 
   (3) This section shall not apply to: 
     (i) Uses of hazardous chemicals which do not meet the definition of laboratory use, and in such cases, the employer shall comply with the relevant standard in 29 CFR part 1910, subpart Z, even if such use occurs in a laboratory. 
     (ii) Laboratory uses of hazardous chemicals which provide no potential for employee exposure. Examples of such conditions might include: 
      (A) Procedures using chemically-impregnated test media such as Dip-and-Read tests where a reagent strip is dipped into the specimen to be tested and the results are interpreted by comparing the color reaction to a color chart supplied by the manufacturer of the test strip; and 
      (B) Commercially prepared kits such as those used in performing pregnancy tests in which all of the reagents needed to conduct the test are contained in the kit. 
  (b) Definitions - 
   Action level means a concentration designated in 29 CFR part 1910 for a specific substance, calculated as an eight (8)-hour time-weighted average, which initiates certain required activities such as exposure monitoring and medical surveillance. 
   Assistant Secretary means the Assistant Secretary of Labor for Occupational Safety and Health, U.S. Department of Labor, or designee. 
   Carcinogen (see select carcinogen). 
   Chemical Hygiene Officer means an employee who is designated by the employer, and who is qualified by training or experience, to provide technical guidance in the development and implementation of the provisions of the Chemical Hygiene Plan. This definition is not intended to place limitations on the position description or job classification that the designated indvidual shall hold within the employer's organizational structure. 
   Chemical Hygiene Plan means a written program developed and implemented by the employer which sets forth procedures, equipment, personal protective equipment and work practices that 
     (i) are capable of protecting employees from the health hazards presented by hazardous chemicals used in that particular workplace and 
     (ii) meets the requirements of paragraph (e) of this section. 
   Designated area means an area which may be used for work with "select carcinogens," reproductive toxins or substances which have a high degree of acute toxicity. A designated area may be the entire laboratory, an area of a laboratory or a device such as a laboratory hood. 
   Emergency means any occurrence such as, but not limited to, equipment failure, rupture of containers or failure of control equipment which results in an uncontrolled release of a hazardous chemical into the workplace. 
   Employee means an individual employed in a laboratory workplace who may be exposed to hazardous chemicals in the course of his or her assignments. 
   Hazardous chemical means any chemical which is classified as health hazard or simple asphyxiant in accordance with the Hazard Communication Standard (§ 1910.1200). 
   Health hazard means a chemical that is classified as posing one of the following hazardous effects: Acute toxicity (any route of exposure); skin corrosion or irritation; serious eye damage or eye irritation; respiratory or skin sensitization; germ cell mutagenicity; carcinogenity; reproductive toxicity; specific target organ toxicity (single or repeated exposure); aspiration hazard. The criteria for determining whether a chemical is classified as a health hazard are detailed in appendix A of the Hazard Communication Standard (§ 1910.1200) and § 1910.1200(c) (definition of "simple asphyxiant"). 
   Laboratory means a facility where the "laboratory use of hazardous chemicals" occurs. It is a workplace where relatively small quantities of hazardous chemicals are used on a non-production basis. 
   Laboratory scale means work with substances in which the containers used for reactions, transfers, and other handling of substances are designed to be easily and safely manipulated by one person. "Laboratory scale" excludes those workplaces whose function is to produce commercial quantities of materials. 
   Laboratory-type hood means a device located in a laboratory, enclosure on five sides with a moveable sash or fixed partial enclosed on the remaining side; constructed and maintained to draw air from the laboratory and to prevent or minimize the escape of air contaminants into the laboratory; and allows chemical manipulations to be conducted in the enclosure without insertion of any portion of the employee's body other than hands and arms. 
   Walk-in hoods with adjustable sashes meet the above definition provided that the sashes are adjusted during use so that the airflow and the exhaust of air contaminants are not compromised and employees do not work inside the enclosure during the release of airborne hazardous chemicals. 
   Laboratory use of hazardous chemicals means handling or use of such chemicals in which all of the following conditions are met: 
     (i) Chemical manipulations are carried out on a "laboratory scale;" 
     (ii) Multiple chemical procedures or chemicals are used; 
     (iii) The procedures involved are not part of a production process, nor in any way simulate a production process; and 
     (iv) "Protective laboratory practices and equipment" are available and in common use to minimize the potential for employee exposure to hazardous chemicals. 
   Medical consultation means a consultation which takes place between an employee and a licensed physician for the purpose of determining what medical examinations or procedures, if any, are appropriate in cases where a significant exposure to a hazardous chemical may have taken place. 
   Mutagen means chemicals that cause permanent changes in the amount or structure of the genetic material in a cell. Chemicals classified as mutagens in accordance with the Hazard Communication Standard (§ 1910.1200) shall be considered mutagens for purposes of this section. 
   Physical hazard means a chemical that is classified as posing one of the following hazardous effects: Explosive; flammable (gases, aerosols, liquids, or solids); oxidizer (liquid, solid, or gas); self reactive; pyrophoric (gas, liquid or solid); self-heating; organic peroxide; corrosive to metal; gas under pressure; in contact with water emits flammable gas; or combustible dust. The criteria for determining whether a chemical is classified as a physical hazard are in appendix B of the Hazard Communication Standard (§ 1910.1200) and § 1910.1200(c) (definitions of "combustible dust" and "pyrophoric gas"). 
   Protective laboratory practices and equipment means those laboratory procedures, practices and equipment accepted by laboratory health and safety experts as effective, or that the employer can show to be effective, in minimizing the potential for employee exposure to hazardous chemicals. 
   Reproductive toxins mean chemicals that affect the reproductive capabilities including adverse effects on sexual function and fertility in adult males and females, as well as adverse effects on the development of the offspring. Chemicals classified as reproductive toxins in accordance with the Hazard Communication Standard (§1910.1200) shall be considered reproductive toxins for purposes of this section. 
   Select carcinogen means any substance which meets one of the following criteria: 
     (i) It is regulated by OSHA as a carcinogen; or 
     (ii) It is listed under the category, "known to be carcinogens," in the Annual Report on Carcinogens published by the National Toxicology Program (NTP) (latest edition); or 
     (iii) It is listed under Group 1 ("carcinogenic to humans") by the International Agency for Research on Cancer Monographs (IARC) (latest editions); or 
     (iv) It is listed in either Group 2A or 2B by IARC or under the category, "reasonably anticipated to be carcinogens" by NTP, and causes statistically significant tumor incidence in experimental animals in accordance with any of the following criteria: 
      (A) After inhalation exposure of 6-7 hours per day, 5 days per week, for a significant portion of a lifetime to dosages of less than 10 mg/m[3]; 
      (B) After repeated skin application of less than 300 (mg/kg of body weight) per week; or 
      (C) After oral dosages of less than 50 mg/kg of body weight per day. 
  (c) Permissible exposure limits. For laboratory uses of OSHA regulated substances, the employer shall assure that laboratory employees' exposures to such substances do not exceed the permissible exposure limits specified in 29 CFR part 1910, subpart Z. 
  (d) Employee exposure determination - 
   (1) Initial monitoring. The employer shall measure the employee's exposure to any substance regulated by a standard which requires monitoring if there is reason to believe that exposure levels for that substance routinely exceed the action level (or in the absence of an action level, the PEL). 
   (2) Periodic monitoring. If the initial monitoring prescribed by paragraph (d)(1) of this section discloses employee exposure over the action level (or in the absence of an action level, the PEL), the employer shall immediately comply with the exposure monitoring provisions of the relevant standard. 
   (3) Termination of monitoring. Monitoring may be terminated in accordance with the relevant standard. 
   (4) Employee notification of monitoring results. The employer shall, within 15 working days after the receipt of any monitoring results, notify the employee of these results in writing either individually or by posting results in an appropriate location that is accessible to employees. 
  (e) Chemical hygiene plan - General. (Appendix A of this section is non-mandatory but provides guidance to assist employers in the development of the Chemical Hygiene Plan.) 
   (1) Where hazardous chemicals as defined by this standard are used in the workplace, the employer shall develop and carry out the provisions of a written Chemical Hygiene Plan which is: 
     (i) Capable of protecting employees from health hazards associated with hazardous chemicals in that laboratory and 
     (ii) Capable of keeping exposures below the limits specified in paragraph (c) of this section. 
   (2) The Chemical Hygiene Plan shall be readily available to employees, employee representatives and, upon request, to the Assistant Secretary. 
   (3) The Chemical Hygiene Plan shall include each of the following elements and shall indicate specific measures that the employer will take to ensure laboratory employee protection: 
     (i) Standard operating procedures relevant to safety and health considerations to be followed when laboratory work involves the use of hazardous chemicals; 
     (ii) Criteria that the employer will use to determine and implement control measures to reduce employee exposure to hazardous chemicals including engineering controls, the use of personal protective equipment and hygiene practices; particular attention shall be given to the selection of control measures for chemicals that are known to be extremely hazardous; 
     (iii) A requirement that fume hoods and other protective equipment are functioning properly and specific measures that shall be taken to ensure proper and adequate performance of such equipment; 
     (iv) Provisions for employee information and training as prescribed in paragraph (f) of this section; 
     (v) The circumstances under which a particular laboratory operation, procedure or activity shall require prior approval from the employer or the employer's designee before implementation; 
     (vi) Provisions for medical consultation and medical examinations in accordance with paragraph (g) of this section; 
     (vii) Designation of personnel responsible for implementation of the Chemical Hygiene Plan including the assignment of a Chemical Hygiene Officer and, if appropriate, establishment of a Chemical Hygiene Committee; and 
     (viii) Provisions for additional employee protection for work with particularly hazardous substances. These include "select carcinogens," reproductive toxins and substances which have a high degree of acute toxicity. Specific consideration shall be given to the following provisions which shall be included where appropriate: 
      (A) Establishment of a designated area; 
      (B) Use of containment devices such as fume hoods or glove boxes; 
      (C) Procedures for safe removal of contaminated waste; and 
      (D) Decontamination procedures. 
   (4) The employer shall review and evaluate the effectiveness of the Chemical Hygiene Plan at least annually and update it as necessary. 
  (f) Employee information and training. 
   (1) The employer shall provide employees with information and training to ensure that they are apprised of the hazards of chemicals present in their work area. 
   (2) Such information shall be provided at the time of an employee's initial assignment to a work area where hazardous chemicals are present and prior to assignments involving new exposure situations. The frequency of refresher information and training shall be determined by the employer. 
   (3) Information. Employees shall be informed of: 
     (i) The contents of this standard and its appendices which shall be made available to employees; 
     (ii) The location and availability of the employer's Chemical Hygiene Plan; 
     (iii) The permissible exposure limits for OSHA regulated substances or recommended exposure limits for other hazardous chemicals where there is no applicable OSHA standard; 
     (iv) Signs and symptoms associated with exposures to hazardous chemicals used in the laboratory; and 
     (v) The location and availability of known reference material on the hazards, safe handling, storage and disposal of hazardous chemicals found in the laboratory including, but not limited to, safety data sheets received from the chemical supplier. 
   (4) Training. 
     (i) Employee training shall include: 
      (A) Methods and observations that may be used to detect the presence or release of a hazardous chemical (such as monitoring conducted by the employer, continuous monitoring devices, visual appearance or odor of hazardous chemicals when being released, etc.); 
      (B) The physical and health hazards of chemicals in the work area; and 
      (C) The measures employees can take to protect themselves from these hazards, including specific procedures the employer has implemented to protect employees from exposure to hazardous chemicals, such as appropriate work practices, emergency procedures, and personal protective equipment to be used. 
     (ii) The employee shall be trained on the applicable details of the employer's written Chemical Hygiene Plan. 
  (g) Medical consultation and medical examinations. 
   (1) The employer shall provide all employees who work with hazardous chemicals an opportunity to receive medical attention, including any follow-up examinations which the examining physician determines to be necessary, under the following circumstances: 
     (i) Whenever an employee develops signs or symptoms associated with a hazardous chemical to which the employee may have been exposed in the laboratory, the employee shall be provided an opportunity to receive an appropriate medical examination. 
     (ii) Where exposure monitoring reveals an exposure level routinely above the action level (or in the absence of an action level, the PEL) for an OSHA regulated substance for which there are exposure monitoring and medical surveillance requirements, medical surveillance shall be established for the affected employee as prescribed by the particular standard. 
     (iii) Whenever an event takes place in the work area such as a spill, leak, explosion or other occurrence resulting in the likelihood of a hazardous exposure, the affected employee shall be provided an opportunity for a medical consultation. Such consultation shall be for the purpose of determining the need for a medical examination. 
   (2) All medical examinations and consultations shall be performed by or under the direct supervision of a licensed physician and shall be provided without cost to the employee, without loss of pay and at a reasonable time and place. 
   (3) Information provided to the physician. The employer shall provide the following information to the physician: 
     (i) The identity of the hazardous chemical(s) to which the employee may have been exposed; 
     (ii) A description of the conditions under which the exposure occurred including quantitative exposure data, if available; and 
     (iii) A description of the signs and symptoms of exposure that the employee is experiencing, if any. 
   (4) Physician's written opinion. 
     (i) For examination or consultation required under this standard, the employer shall obtain a written opinion from the examining physician which shall include the following: 
      (A) Any recommendation for further medical follow-up; 
      (B) The results of the medical examination and any associated tests; 
      (C) Any medical condition which may be revealed in the course of the examination which may place the employee at increased risk as a result of exposure to a hazardous chemical found in the workplace; and 
      (D) A statement that the employee has been informed by the physician of the results of the consultation or medical examination and any medical condition that may require further examination or treatment. 
     (ii) The written opinion shall not reveal specific findings of diagnoses unrelated to occupational exposure. 
  (h) Hazard identification. 
   (1) With respect to labels and safety data sheets: 
     (i) Employers shall ensure that labels on incoming containers of hazardous chemicals are not removed or defaced. 
     (ii) Employers shall maintain any safety data sheets that are received with incoming shipments of hazardous chemicals, and ensure that they are readily accessible to laboratory employees. 
   (2) The following provisions shall apply to chemical substances developed in the laboratory: 
     (i) If the composition of the chemical substance which is produced exclusively for the laboratory's use is known, the employer shall determine if it is a hazardous chemical as defined in paragraph (b) of this section. If the chemical is determined to be hazardous, the employer shall provide appropriate training as required under paragraph (f) of this section. 
     (ii) If the chemical produced is a byproduct whose composition is not known, the employer shall assume that the substance is hazardous and shall implement paragraph (e) of this section. 
     (iii) If the chemical substance is produced for another user outside of the laboratory, the employer shall comply with the Hazard Communication Standard (29 CFR 1910.1200) including the requirements for preparation of safety data sheets and labeling. 
  (i) Use of respirators. Where the use of respirators is necessary to maintain exposure below permissible exposure limits, the employer shall provide, at no cost to the employee, the proper respiratory equipment. Respirators shall be selected and used in accordance with the requirements of 29 CFR 1910.134. 
  (j) Recordkeeping. 
   (1) The employer shall establish and maintain for each employee an accurate record of any measurements taken to monitor employee exposures and any medical consultation and examinations including tests or written opinions required by this standard. 
   (2) The employer shall assure that such records are kept, transferred, and made available in accordance with 29 CFR 1910.20. 
  (k) [Reserved] 
  (l) Appendices. The information contained in the appendices is not intended, by itself, to create any additional obligations not otherwise imposed or to detract from any existing obligation. 
Appendix A to § 1910.1450 - National Research Council Recommendations Concerning Chemical Hygiene In Laboratories (Non-Mandatory) 
To assist employers in developing an appropriate laboratory Chemical Hygiene Plan (CHP), the following non-mandatory recommendations were based on the National Research Council's (NRC) 2011 edition of "Prudent Practices in the Laboratory: Handling and Management of Chemical Hazards." This reference, henceforth referred to as "Prudent Practices," is available from the National Academies Press, 500 Fifth Street NW., Washington DC 20001 (www.nap.edu). "Prudent Practices" is cited because of its wide distribution and acceptance and because of its preparation by recognized authorities in the laboratory community through the sponsorship of the NRC. However, these recommendations do not modify any requirements of the OSHA Laboratory standard. This appendix presents pertinent recommendations from "Prudent Practices," organized into a form convenient for quick reference during operation of a laboratory and during development and application of a CHP. For a detailed explanation and justification for each recommendation, consult "Prudent Practices." 
"Prudent Practices" deals with both general laboratory safety and many types of chemical hazards, while the Laboratory standard is concerned primarily with chemical health hazards as a result of chemical exposures. The recommendations from "Prudent Practices" have been paraphrased, combined, or otherwise reorganized in order to adapt them for this purpose. However, their sense has not been changed. 
Section F contains information from the U.S. Chemical Safety Board's (CSB) Fiscal Year 2011 Annual Performance and Accountability report and Section F contains recommendations extracted from the CSB's 2011 case study, "Texas Tech University Laboratory Explosion," available from: http://www.csb.gov/. 
Culture of Safety 
With the promulgation of the Occupational Safety and Health Administration (OSHA) Laboratory standard (29 CFR 1910.1450), a culture of safety consciousness, accountability, organization, and education has developed in industrial, governmental, and academic laboratories. Safety and training programs have been implemented to promote the safe handling of chemicals from ordering to disposal, and to train laboratory personnel in safe practices. Laboratory personnel must realize that the welfare and safety of each individual depends on clearly defined attitudes of teamwork and personal responsibility. Learning to participate in this culture of habitual risk assessment, experiment planning, and consideration of worst-case possibilities - for oneself and one's fellow workers - is as much part of a scientific education as learning the theoretical background of experiments or the step-by-step protocols for doing them in a professional manner. A crucial component of chemical education for all personnel is to nurture basic attitudes and habits of prudent behavior so that safety is a valued and inseparable part of all laboratory activities throughout their career. 
Over the years, special techniques have been developed for handling chemicals safely. Local, state, and federal regulations hold institutions that sponsor chemical laboratories accountable for providing safe working environments. Beyond regulation, employers and scientists also hold themselves personally responsible for their own safety, the safety of their colleagues and the safety of the general public. A sound safety organization that is respected by all requires the participation and support of laboratory administrators, workers, and students. A successful health and safety program requires a daily commitment from everyone in the organization. To be most effective, safety and health must be balanced with, and incorporated into, laboratory processes. A strong safety and health culture is the result of positive workplace attitudes - from the chief executive officer to the newest hire; involvement and buy-in of all members of the workforce; mutual, meaningful, and measurable safety and health improvement goals; and policies and procedures that serve as reference tools, rather than obscure rules. 
In order to perform their work in a prudent manner, laboratory personnel must consider the health, physical, and environmental hazards of the chemicals they plan to use in an experiment. However, the ability to accurately identify and assess laboratory hazards must be taught and encouraged through training and ongoing organizational support. This training must be at the core of every good health and safety program. For management to lead, personnel to assess worksite hazards, and hazards to be eliminated or controlled, everyone involved must be trained. 
A. General Principles 
1. Minimize All Chemical Exposures and Risks 
Because few laboratory chemicals are without hazards, general precautions for handling all laboratory chemicals should be adopted. In addition to these general guidelines, specific guidelines for chemicals that are used frequently or are particularly hazardous should be adopted. 
Laboratory personnel should conduct their work under conditions that minimize the risks from both known and unknown hazardous substances. Before beginning any laboratory work, the hazards and risks associated with an experiment or activity should be determined and the necessary safety precautions implemented. Every laboratory should develop facility-specific policies and procedures for the highest-risk materials and procedures used in their laboratory. To identify these, consideration should be given to past accidents, process conditions, chemicals used in large volumes, and particularly hazardous chemicals. 
Perform Risk Assessments for Hazardous Chemicals and Procedures Prior to Laboratory Work: 
(a) Identify chemicals to be used, amounts required, and circumstances of use in the experiment. Consider any special employee or laboratory conditions that could create or increase a hazard. Consult sources of safety and health information and experienced scientists to ensure that those conducting the risk assessment have sufficient expertise. 
(b) Evaluate the hazards posed by the chemicals and the experimental conditions. The evaluation should cover toxic, physical, reactive, flammable, explosive, radiation, and biological hazards, as well as any other potential hazards posed by the chemicals. 
(c) For a variety of physical and chemical reasons, reaction scale-ups pose special risks, which merit additional prior review and precautions. 
(d) Select appropriate controls to minimize risk, including use of engineering controls, administrative controls, and personal protective equipment (PPE) to protect workers from hazards. The controls must ensure that OSHA's Permissible Exposure Limits (PELs) are not exceeded. Prepare for contingencies and be aware of the institutional procedures in the event of emergencies and accidents. 
One sample approach to risk assessment is to answer these five questions: 
(a) What are the hazards? 
(b) What is the worst thing that could happen? 
(c) What can be done to prevent this from happening? 
(d) What can be done to protect from these hazards? 
(e) What should be done if something goes wrong? 
2. Avoid Underestimation of Risk 
Even for substances of no known significant hazard, exposure should be minimized; when working with substances that present special hazards, special precautions should be taken. Reference should be made to the safety data sheet (SDS) that is provided for each chemical. Unless otherwise known, one should assume that any mixture will be more toxic than its most toxic component and that all substances of unknown toxicity are toxic. 
Determine the physical and health hazards associated with chemicals before working with them. This determination may involve consulting literature references, laboratory chemical safety summaries (LCSSs), SDSs, or other reference materials. Consider how the chemicals will be processed and determine whether the changing states or forms will change the nature of the hazard. Review your plan, operating limits, chemical evaluations and detailed risk assessment with other chemists, especially those with experience with similar materials and protocols. 
Before working with chemicals, know your facility's policies and procedures for how to handle an accidental spill or fire. Emergency telephone numbers should be posted in a prominent area. Know the location of all safety equipment and the nearest fire alarm and telephone. 
3. Adhere to the Hierarchy of Controls 
The hierarchy of controls prioritizes intervention strategies based on the premise that the best way to control a hazard is to systematically remove it from the workplace, rather than relying on employees to reduce their exposure. The types of measures that may be used to protect employees (listed from most effective to least effective) are: engineering controls, administrative controls, work practices, and PPE. Engineering controls, such as chemical hoods, physically separate the employee from the hazard. Administrative controls, such as employee scheduling, are established by management to help minimize the employees' exposure time to hazardous chemicals. Work practice controls are tasks that are performed in a designated way to minimize or eliminate hazards. Personal protective equipment and apparel are additional protection provided under special circumstances and when exposure is unavoidable. 
Face and eye protection is necessary to prevent ingestion and skin absorption of hazardous chemicals. At a minimum, safety glasses, with side shields, should be used for all laboratory work. Chemical splash goggles are more appropriate than regular safety glasses to protect against hazards such as projectiles, as well as when working with glassware under reduced or elevated pressures (e.g., sealed tube reactions), when handling potentially explosive compounds (particularly during distillations), and when using glassware in high-temperature operations. Do not allow laboratory chemicals to come in contact with skin. Select gloves carefully to ensure that they are impervious to the chemicals being used and are of correct thickness to allow reasonable dexterity while also ensuring adequate barrier protection. 
Lab coats and gloves should be worn when working with hazardous materials in a laboratory. Wear closed-toe shoes and long pants or other clothing that covers the legs when in a laboratory where hazardous chemicals are used. Additional protective clothing should be used when there is significant potential for skin-contact exposure to chemicals. The protective characteristics of this clothing must be matched to the hazard. Never wear gloves or laboratory coats outside the laboratory or into areas where food is stored and consumed. 
4. Provide Laboratory Ventilation 
The best way to prevent exposure to airborne substances is to prevent their escape into the working atmosphere by the use of hoods and other ventilation devices. To determine the best choice for laboratory ventilation using engineering controls for personal protection, employers are referred to Table 9.3 of the 2011 edition of "Prudent Practices." Laboratory chemical hoods are the most important components used to protect laboratory personnel from exposure to hazardous chemicals. 
(a) Toxic or corrosive chemicals that require vented storage should be stored in vented cabinets instead of in a chemical hood. 
(b) Chemical waste should not be disposed of by evaporation in a chemical hood. 
(c) Keep chemical hood areas clean and free of debris at all times. 
(d) Solid objects and materials, such as paper, should be prevented from entering the exhaust ducts as they can reduce the air flow. 
(e) Chemical hoods should be maintained, monitored and routinely tested for proper performance. 
A laboratory ventilation system should include the following characteristics and practices: 
(a) Heating and cooling should be adequate for the comfort of workers and operation of equipment. Before modification of any building HVAC, the impact on laboratory or hood ventilation should be considered, as well as how laboratory ventilation changes may affect the building HVAC. 
(b) A negative pressure differential should exist between the amount of air exhausted from the laboratory and the amount supplied to the laboratory to prevent uncontrolled chemical vapors from leaving the laboratory. 
(c) Local exhaust ventilation devices should be appropriate to the materials and operations in the laboratory. 
(d) The air in chemical laboratories should be continuously replaced so that concentrations of odoriferous or toxic substances do not increase during the workday. 
(e) Laboratory air should not be recirculated but exhausted directly outdoors. 
(f) Air pressure should be negative with respect to the rest of the building. Local capture equipment and systems should be designed only by an experienced engineer or industrial hygienist. 
(g) Ventilation systems should be inspected and maintained on a regular basis. There should be no areas where air remains static or areas that have unusually high airflow velocities. 
Before work begins, laboratory workers should be provided with proper training that includes how to use the ventilation equipment, how to ensure that it is functioning properly, the consequences of improper use, what to do in the event of a system failure or power outage, special considerations, and the importance of signage and postings. 
5. Institute a Chemical Hygiene Program 
A comprehensive chemical hygiene program is required. It should be designed to minimize exposures, injuries, illnesses and incidents. There should be a regular, continuing effort that includes program oversight, safe facilities, chemical hygiene planning, training, emergency preparedness and chemical security. The chemical hygiene program must be reviewed annually and updated as necessary whenever new processes, chemicals, or equipment is implemented. Its recommendations should be followed in all laboratories. 
6. Observe the PELs and TLVs 
OSHA's Permissible Exposure Limits (PELs) must not be exceeded. The American Conference of Governmental Industrial Hygienists' Threshold Limit Values (TLVs) should also not be exceeded. 
B. Responsibilities 
Persons responsible for chemical hygiene include, but are not limited to, the following: 
1. Chemical Hygiene Officer 
(a) Establishes, maintains, and revises the chemical hygiene plan (CHP). 
(b) Creates and revises safety rules and regulations. 
(c) Monitors procurement, use, storage, and disposal of chemicals. 
(d) Conducts regular inspections of the laboratories, preparations rooms, and chemical storage rooms, and submits detailed laboratory inspection reports to administration. 
(e) Maintains inspection, personnel training, and inventory records. 
(f) Assists laboratory supervisors in developing and maintaining adequate facilities. 
(g) Seeks ways to improve the chemical hygiene program. 
2. Department Chairperson or Director 
(a) Assumes responsibility for personnel engaged in the laboratory use of hazardous chemicals. 
(b) Provides the chemical hygiene officer (CHO) with the support necessary to implement and maintain the CHP. 
(c) After receipt of laboratory inspection report from the CHO, meets with laboratory supervisors to discuss cited violations and to ensure timely actions to protect trained laboratory personnel and facilities and to ensure that the department remains in compliance with all applicable federal, state, university, local and departmental codes and regulations. 
(d) Provides budgetary arrangements to ensure the health and safety of the departmental personnel, visitors, and students. 
3. Departmental Safety Committee reviews accident reports and makes appropriate recommendations to the department chairperson regarding proposed changes in the laboratory procedures. 
4. Laboratory Supervisor or Principal Investigator has overall responsibility for chemical hygiene in the laboratory, including responsibility to: 
(a) Ensure that laboratory personnel comply with the departmental CHP and do not operate equipment or handle hazardous chemicals without proper training and authorization. 
(b) Always wear personal protective equipment (PPE) that is compatible to the degree of hazard of the chemical. 
(c) Follow all pertinent safety rules when working in the laboratory to set an example. 
(d) Review laboratory procedures for potential safety problems before assigning to other laboratory personnel. 
(e) Ensure that visitors follow the laboratory rules and assumes responsibility for laboratory visitors. 
(f) Ensure that PPE is available and properly used by each laboratory employee and visitor. 
(g) Maintain and implement safe laboratory practices. 
(h) Provide regular, formal chemical hygiene and housekeeping inspections, including routine inspections of emergency equipment; 
(i) Monitor the facilities and the chemical fume hoods to ensure that they are maintained and function properly. Contact the appropriate person, as designated by the department chairperson, to report problems with the facilities or the chemical fume hoods. 
5. Laboratory Personnel 
(a) Read, understand, and follow all safety rules and regulations that apply to the work area; 
(b) Plan and conduct each operation in accordance with the institutional chemical hygiene procedures; 
(c) Promote good housekeeping practices in the laboratory or work area. 
(d) Notify the supervisor of any hazardous conditions or unsafe work practices in the work area. 
(e) Use PPE as appropriate for each procedure that involves hazardous chemicals. 
C. The Laboratory Facility 
General Laboratory Design Considerations 
Wet chemical spaces and those with a higher degree of hazard should be separated from other spaces by a wall or protective barrier wherever possible. If the areas cannot be separated, then workers in lower hazard spaces may require additional protection from the hazards in connected spaces. 
1. Laboratory Layout and Furnishing 
(a) Work surfaces should be chemically resistant, smooth, and easy to clean. 
(b) Hand washing sinks for hazardous materials may require elbow, foot, or electronic controls for safe operation. 
(c) Wet laboratory areas should have chemically resistant, impermeable, slip-resistant flooring. 
(d) Walls should be finished with a material that is easy to clean and maintain. 
(e) Doors should have view panels to prevent accidents and should open in the direction of egress. 
(f) Operable windows should not be present in laboratories, particularly if there are chemical hoods or other local ventilation systems present. 
2. Safety Equipment and Utilities 
(a) An adequate number and placement of safety showers, eyewash units, and fire extinguishers should be provided for the laboratory. 
(b) Use of water sprinkler systems is resisted by some laboratories because of the presence of electrical equipment or water-reactive materials, but it is still generally safer to have sprinkler systems installed. A fire large enough to trigger the sprinkler system would have the potential to cause far more destruction than the local water damage. 
D. Chemical Hygiene Plan (CHP) 
The OSHA Laboratory standard defines a CHP as "a written program developed and implemented by the employer which sets forth procedures, equipment, personal protective equipment and work practices that are capable of protecting employees from the health hazards presented by hazardous chemicals used in that particular workplace." (29 CFR 1910.1450(b)). The Laboratory Standard requires a CHP: "Where hazardous chemicals as defined by this standard are used in the workplace, the employer shall develop and carry out the provisions of a written Chemical Hygiene Plan." (29 CFR 1910.1450(e)(1)). The CHP is the foundation of the laboratory safety program and must be reviewed and updated, as needed, and at least on an annual basis to reflect changes in policies and personnel. A CHP should be facility specific and can assist in promoting a culture of safety to protect workers from exposure to hazardous materials. 
1. The Laboratory's CHP must be readily available to workers and capable of protecting workers from health hazards and minimizing exposure. Include the following topics in the CHP: 
(a) Individual chemical hygiene responsibilities; 
(b) Standard operating procedures; 
(c) Personal protective equipment, engineering controls and apparel; 
(d) Laboratory equipment; 
(e) Safety equipment; 
(f) Chemical management; 
(g) Housekeeping; 
(h) Emergency procedures for accidents and spills; 
(i) Chemical waste; 
(j) Training; 
(k) Safety rules and regulations; 
(l) Laboratory design and ventilation; 
(m) Exposure monitoring; 
(n) Compressed gas safety; 
(o) Medical consultation and examination. 
It should be noted that the nature of laboratory work may necessitate addressing biological safety, radiation safety and security issues. 
2. Chemical Procurement, Distribution, and Storage 
Prudent chemical management includes the following processes: 
Chemical Procurement: 
(a) Information on proper handling, storage, and disposal should be known to those who will be involved before a substance is received. 
(b) Only containers with adequate identifying labels should be accepted. 
(c) Ideally, a central location should be used for receiving all chemical shipments. 
(d) Shipments with breakage or leakage should be refused or opened in a chemical hood. 
(e) Only the minimum amount of the chemical needed to perform the planned work should be ordered. 
(f) Purchases of high risk chemicals should be reviewed and approved by the CHO. 
(g) Proper protective equipment and handling and storage procedures should be in place before receiving a shipment. 
Chemical Storage: 
(a) Chemicals should be separated and stored according to hazard category and compatibility. 
(b) SDS and label information should be followed for storage requirements. 
(c) Maintain existing labels on incoming containers of chemicals and other materials. 
(d) Labels on containers used for storing hazardous chemicals must include the chemical identification and appropriate hazard warnings. 
(e) The contents of all other chemical containers and transfer vessels, including, but not limited to, beakers, flasks, reaction vessels, and process equipment, should be properly identified. 
(f) Chemical shipments should be dated upon receipt and stock rotated. 
(g) Peroxide formers should be dated upon receipt, again dated upon opening, and stored away from heat and light with tight-fitting, nonmetal lids. 
(h) Open shelves used for chemical storage should be secured to the wall and contain 3⁄4-inch lips. Secondary containment devices should be used as necessary. 
(i) Consult the SDS and keep incompatibles separate during transport, storage, use, and disposal. 
(j) Oxidizers, reducing agents, and fuels should be stored separately to prevent contact in the event of an accident. 
(k) Chemicals should not be stored in the chemical hood, on the floor, in areas of egress, on the benchtop, or in areas near heat or in direct sunlight. 
(l) Laboratory-grade, flammable-rated refrigerators and freezers should be used to store sealed chemical containers of flammable liquids that require cool storage. Do not store food or beverages in the laboratory refrigerator. 
(m) Highly hazardous chemicals should be stored in a well-ventilated and secure area designated for that purpose. 
(n) Flammable chemicals should be stored in a spark-free environment and in approved flammable-liquid containers and storage cabinets. Grounding and bonding should be used to prevent static charge buildups when dispensing solvents. 
(o) Chemical storage and handling rooms should be controlled-access areas. They should have proper ventilation, appropriate signage, diked floors, and fire suppression systems. 
Chemical Handling: 
(a) As described above, a risk assessment should be conducted prior to beginning work with any hazardous chemical for the first time. 
(b) All SDS and label information should be read before using a chemical for the first time. 
(c) Trained laboratory workers should ensure that proper engineering controls (ventilation) and PPE are in place. 
Chemical Inventory: 
(a) Prudent management of chemicals in any laboratory is greatly facilitated by keeping an accurate inventory of the chemicals stored. 
(b) Unneeded items should be discarded or returned to the storeroom. 
Transporting Chemicals: 
(a) Secondary containment devices should be used when transporting chemicals. 
(b) When transporting chemicals outside of the laboratory or between stockrooms and laboratories, the transport container should be break-resistant. 
(c) High-traffic areas should be avoided. 
Transferring Chemicals: 
(a) Use adequate ventilation (such as a fume hood) when transferring even a small amount of a particularly hazardous substance (PHS). 
(b) While drum storage is not appropriate for laboratories, chemical stockrooms may purchase drum quantities of solvents used in high volumes. Ground and bond the drum and receiving vessel when transferring flammable liquids from a drum to prevent static charge buildup. 
(c) If chemicals from commercial sources are repackaged into transfer vessels, the new containers should be labeled with all essential information on the original container. 
Shipping Chemicals: Outgoing chemical shipments must meet all applicable Department of Transportation (DOT) regulations and should be authorized and handled by the institutional shipper. 
3. Waste Management 
A waste management plan should be in place before work begins on any laboratory activity. The plan should utilize the following hierarchy of practices: 
(a) Reduce waste sources. The best approach to minimize waste generation is by reducing the scale of operations, reducing its formation during operations, and, if possible, substituting less hazardous chemicals for a particular operation. 
(b) Reuse surplus materials. Only the amount of material necessary for an experiment should be purchased, and, if possible, materials should be reused. 
(c) Recycle waste. If waste cannot be prevented or minimized, the organization should consider recycling chemicals that can be safely recovered or used as fuel. 
(d) Dispose of waste properly. Sink disposal may not be appropriate. Proper waste disposal methods include incineration, treatment, and land disposal. The organization's environmental health and safety (EHS) office should be consulted in determining which methods are appropriate for different types of waste. 
Collection and Storage of Waste: 
(a) Chemical waste should be accumulated at or near the point of generation, under the control of laboratory workers. 
(b) Each waste type should be stored in a compatible container pending transfer or disposal. Waste containers should be clearly labeled and kept sealed when not in use. 
(c) Incompatible waste types should be kept separate to ensure that heat generation, gas evolution, or another reaction does not occur. 
(d) Waste containers should be segregated by how they will be managed. Waste containers should be stored in a designated location that does not interfere with normal laboratory operations. Ventilated storage and secondary containment may be appropriate for certain waste types. 
(e) Waste containers should be clearly labeled and kept sealed when not in use. Labels should include the accumulation start date and hazard warnings as appropriate. 
(f) Non-explosive electrical systems, grounding and bonding between floors and containers, and non-sparking conductive floors and containers should be used in the central waste accumulation area to minimize fire and explosion hazards. Fire suppression systems, specialized ventilation systems, and dikes should be installed in the central waste accumulation area. Waste management workers should be trained in proper waste handling procedures as well as contingency planning and emergency response. Trained laboratory workers most familiar with the waste should be actively involved in waste management decisions to ensure that the waste is managed safely and efficiently. Engineering controls should be implemented as necessary, and personal protective equipment should be worn by workers involved in waste management. 
4. Inspection Program 
Maintenance and regular inspection of laboratory equipment are essential parts of the laboratory safety program. Management should participate in the design of a laboratory inspection program to ensure that the facility is safe and healthy, workers are adequately trained, and proper procedures are being followed. 
Types of inspections: The program should include an appropriate combination of routine inspections, self-audits, program audits, peer inspections, EHS inspections, and inspections by external entities. 
Elements of an inspection: 
(a) Inspectors should bring a checklist to ensure that all issues are covered and a camera to document issues that require correction. 
(b) Conversations with workers should occur during the inspection, as they can provide valuable information and allow inspectors an opportunity to show workers how to fix problems. 
(c) Issues resolved during the inspection should be noted. 
(d) An inspection report containing all findings and recommendations should be prepared for management and other appropriate workers. 
(e) Management should follow-up on the inspection to ensure that all corrections are implemented. 
5. Medical Consultation and Examination 
The employer must provide all employees who work with hazardous chemicals an opportunity to receive medical attention, including any follow-up examinations that the examining physician determines to be necessary, whenever an employee develops signs or symptoms associated with a hazardous chemical to which the employee may have been exposed in the laboratory. If an employee encounters a spill, leak, explosion or other occurrence resulting in the likelihood of a hazardous exposure, the affected employee must be provided an opportunity for a medical consultation by a licensed physician. All medical examinations and consultations must be performed by or under the direct supervision of a licensed physician and must be provided without cost to the employee, without loss of pay and at a reasonable time and place. The identity of the hazardous chemical, a description of the incident, and any signs and symptoms that the employee may experience must be relayed to the physician. 
6. Records 
All accident, fatality, illness, injury, and medical records and exposure monitoring records must be retained by the institution in accordance with the requirements of state and federal regulations (see 29 CFR part 1904 and §1910.1450(j)). Any exposure monitoring results must be provided to affected laboratory staff within 15 working days after receipt of the results (29 CFR 1910.1450(d)(4)). 
7. Signs 
Prominent signs of the following types should be posted: 
(a) Emergency telephone numbers of emergency personnel/facilities, supervisors, and laboratory workers; 
(b) Location signs for safety showers, eyewash stations, other safety and first aid equipment, and exits; and 
(c) Warnings at areas or equipment where special or unusual hazards exist. 
8. Spills and Accidents 
Before beginning an experiment, know your facility's policies and procedures for how to handle an accidental release of a hazardous substance, a spill or a fire. Emergency response planning and training are especially important when working with highly toxic compounds. Emergency telephone numbers should be posted in a prominent area. Know the location of all safety equipment and the nearest fire alarm and telephone. Know who to notify in the event of an emergency. Be prepared to provide basic emergency treatment. Keep your co-workers informed of your activities so they can respond appropriately. Safety equipment, including spill control kits, safety shields, fire safety equipment, PPE, safety showers and eyewash units, and emergency equipment should be available in well-marked highly visible locations in all chemical laboratories. The laboratory supervisor or CHO is responsible for ensuring that all personnel are aware of the locations of fire extinguishers and are trained in their use. After an extinguisher has been used, designated personnel must promptly recharge or replace it (29 CFR 1910.157(c)(4)). The laboratory supervisor or CHO is also responsible for ensuring proper training and providing supplementary equipment as needed. 
Special care must be used when handling solutions of chemicals in syringes with needles. Do not recap needles, especially when they have been in contact with chemicals. Remove the needle and discard it immediately after use in the appropriate sharps containers. Blunt-tip needles are available from a number of commercial sources and should be used unless a sharp needle is required to puncture rubber septa or for subcutaneous injection. 
For unattended operations, laboratory lights should be left on, and signs should be posted to identify the nature of the experiment and the hazardous substances in use. Arrangements should be made, if possible, for other workers to periodically inspect the operation. Information should be clearly posted indicating who to contact in the event of an emergency. Depending on the nature of the hazard, special rules, precautions, and alert systems may be necessary. 
9. Training and Information 
Personnel training at all levels within the organization, is essential. Responsibility and accountability throughout the organization are key elements in a strong safety and health program. The employer is required to provide employees with information and training to ensure that they are apprised of the hazards of chemicals present in their work area (29 CFR 1910.1450(f)). This information must be provided at the time of an employee's initial assignment to a work area where hazardous chemicals are present and prior to assignments involving new exposure situations. The frequency of refresher information and training should be determined by the employer. At a minimum, laboratory personnel should be trained on their facility's specific CHP, methods and observations that may be used to detect the presence or release of a hazardous chemical (such as monitoring conducted by the employer, continuous monitoring devices, visual appearance or odor of hazardous chemicals when being released), the physical and health hazards of chemicals in the work area and means to protect themselves from these hazards. Trained laboratory personnel must know shut-off procedures in case of an emergency. All SDSs must be made available to the employees. 
E. General Procedures for Working With Chemicals 
The risk of laboratory injuries can be reduced through adequate training, improved engineering, good housekeeping, safe work practice and personal behavior. 
1. General Rules for Laboratory Work With Chemicals 
(a) Assigned work schedules should be followed unless a deviation is authorized by the laboratory supervisor. 
(b) Unauthorized experiments should not be performed. 
(c) Plan safety procedures before beginning any operation. 
(d) Follow standard operating procedures at all times. 
(e) Always read the SDS and label before using a chemical. 
(f) Wear appropriate PPE at all times. 
(g) To protect your skin from splashes, spills and drips, always wear long pants and closed-toe shoes. 
(h) Use appropriate ventilation when working with hazardous chemicals. 
(i) Pipetting should never be done by mouth. 
(j) Hands should be washed with soap and water immediately after working with any laboratory chemicals, even if gloves have been worn. 
(k) Eating, drinking, smoking, gum chewing, applying cosmetics, and taking medicine in laboratories where hazardous chemicals are used or stored should be strictly prohibited. 
(l) Food, beverages, cups, and other drinking and eating utensils should not be stored in areas where hazardous chemicals are handled or stored. 
(m) Laboratory refrigerators, ice chests, cold rooms, and ovens should not be used for food storage or preparation. 
(n) Contact the laboratory supervisor, Principal Investigator, CHO or EHS office with all safety questions or concerns. 
(o) Know the location and proper use of safety equipment. 
(p) Maintain situational awareness. 
(q) Make others aware of special hazards associated with your work. 
(r) Notify supervisors of chemical sensitivities or allergies. 
(s) Report all injuries, accidents, incidents, and near misses. 
(t) Unauthorized persons should not be allowed in the laboratory. 
(u) Report unsafe conditions to the laboratory supervisor or CHO. 
(v) Properly dispose of chemical wastes. 
Working Alone in the Laboratory 
Working alone in a laboratory is dangerous and should be strictly avoided. There have been many tragic accidents that illustrate this danger. Accidents are unexpected by definition, which is why coworkers should always be present. Workers should coordinate schedules to avoid working alone. 
Housekeeping 
Housekeeping can help reduce or eliminate a number of laboratory hazards. Proper housekeeping includes appropriate labeling and storage of chemicals, safe and regular cleaning of the facility, and proper arrangement of laboratory equipment. 
2. Nanoparticles and Nanomaterials 
Nanoparticles and nanomaterials have different reactivities and interactions with biological systems than bulk materials, and understanding and exploiting these differences is an active area of research. However, these differences also mean that the risks and hazards associated with exposure to engineered nanomaterials are not well known. Because this is an area of ongoing research, consult trusted sources for the most up to date information available. Note that the higher reactivity of many nanoscale materials suggests that they should be treated as potential sources of ignition, accelerants, and fuel that could result in fire or explosion. Easily dispersed dry nanomaterials may pose the greatest health hazard because of the risk of inhalation. Operations involving these nanomaterials deserve more attention and more stringent controls than those where the nanomaterials are embedded in solid or suspended in liquid matrixes. 
Consideration should be given to all possible routes of exposure to nanomaterials including inhalation, ingestion, injection, and dermal contact (including eye and mucous membranes). Avoid handling nanomaterials in the open air in a free-particle state. Whenever possible, handle and store dispersible nanomaterials, whether suspended in liquids or in a dry particle form, in closed (tightly-sealed) containers. Unless cutting or grinding occurs, nanomaterials that are not in a free form (encapsulated in a solid or a nanocomposite) typically will not require engineering controls. If a synthesis is being performed to create nanomaterials, it is not enough to only consider the final material in the risk assessment, but consider the hazardous properties of the precursor materials as well. 
To minimize laboratory personnel exposure, conduct any work that could generate engineered nanoparticles in an enclosure that operates at a negative pressure differential compared to the laboratory personnel breathing zone. Limited data exist regarding the efficacy of PPE and ventilation systems against exposure to nanoparticles. However, until further information is available, it is prudent to follow standard chemical hygiene practices. Conduct a hazard evaluation to determine PPE appropriate for the level of hazard according to the requirements set forth in OSHA's Personal Protective Equipment standard (29 CFR 1910.132). 
3. Highly Toxic and Explosive/Reactive Chemicals/Materials 
The use of highly toxic and explosive/reactive chemicals and materials has been an area of growing concern. The frequency of academic laboratory incidents in the U.S. is an area of significant concern for the Chemical Safety Board (CSB). The CSB issued a case study on an explosion at Texas Tech University in Lubbock, Texas, which severely injured a graduate student handling a high-energy metal compound. Since 2001, the CSB has gathered preliminary information on 120 different university laboratory incidents that resulted in 87 evacuations, 96 injuries, and three deaths. 
It is recommended that each facility keep a detailed inventory of highly toxic chemicals and explosive/reactive materials. There should be a record of the date of receipt, amount, location, and responsible individual for all acquisitions, syntheses, and disposal of these chemicals. A physical inventory should be performed annually to verify active inventory records. There should be a procedure in place to report security breaches, inventory discrepancies, losses, diversions, or suspected thefts. 
Procedures for disposal of highly toxic materials should be established before any experiments begin, possibly even before the chemicals are ordered. The procedures should address methods for decontamination of any laboratory equipment that comes into contact with highly toxic chemicals. All waste should be accumulated in clearly labeled impervious containers that are stored in unbreakable secondary containment. 
Highly reactive and explosive materials that may be used in the laboratory require appropriate procedures and training. An explosion can occur when a material undergoes a rapid reaction that results in a violent release of energy. Such reactions can happen spontaneously and can produce pressures, gases, and fumes that are hazardous. Some reagents pose a risk on contact with the atmosphere. It is prudent laboratory practice to use a safer alternative whenever possible. 
If at all possible, substitutes for highly acute, chronic, explosive, or reactive chemicals should be considered prior to beginning work and used whenever possible. 
4. Compressed Gas 
Compressed gases expose laboratory personnel to both chemical and physical hazards. It is essential that these are monitored for leaks and have the proper labeling. By monitoring compressed gas inventories and disposing of or returning gases for which there is no immediate need, the laboratory can substantially reduce these risks. Leaking gas cylinders can cause serious hazards that may require an immediate evacuation of the area and activation of the emergency response system. Only appropriately trained hazmat responders may respond to stop a leaking gas cylinder under this situation. 
F. Safety Recommendations - Physical Hazards 
Physical hazards in the laboratory include combustible liquids, compressed gases, reactives, explosives and flammable chemicals, as well as high pressure/energy procedures, sharp objects and moving equipment. Injuries can result from bodily contact with rotating or moving objects, including mechanical equipment, parts, and devices. Personnel should not wear loose-fitting clothing, jewelry, or unrestrained long hair around machinery with moving parts. 
The Chemical Safety Board has identified the following key lessons for laboratories that address both physical and other hazards: 
(1) Ensure that research-specific hazards are evaluated and then controlled by developing specific written protocols and training. 
(2) Expand existing laboratory safety plans to ensure that all safety hazards, including physical hazards of chemicals, are addressed. 
(3) Ensure that the organization's EHS office reports directly to an identified individual/office with organizational authority to implement safety improvements. 
(4) Develop a verification program that ensures that the safety provisions of the CHP are communicated, followed, and enforced at all levels within the organization. 
(5) Document and communicate all laboratory near-misses and previous incidents to track safety, provide opportunities for education and improvement to drive safety changes at the university. 
(6) Manage the hazards unique to laboratory chemical research in the academic environment. Utilize available practice guidance that identifies and describes methodologies to assess and control hazards. 
(7) Written safety protocols and training are necessary to manage laboratory risk. 
G. Emergency Planning 
In addition to laboratory safety issues, laboratory personnel should be familiar with established facility policies and procedures regarding emergency situations. Topics may include, but are not limited to: 
(1) Evacuation procedures - when it is appropriate and alternate routes; 
(2) Emergency shutdown procedures - equipment shutdown and materials that should be stored safely; 
(3) Communications during an emergency - what to expect, how to report, where to call or look for information; 
(4) How and when to use a fire extinguisher; 
(5) Security issues - preventing tailgating and unauthorized access; 
(6) Protocol for absences due to travel restrictions or illness; 
(7) Safe practices for power outage; 
(8) Shelter in place - when it is appropriate; 
(9) Handling suspicious mail or phone calls; 
(10) Laboratory-specific protocols relating to emergency planning and response; 
(11) Handling violent behavior in the workplace; and 
(12) First-aid and CPR training, including automated external defibrillator training if available. 
It is prudent that laboratory personnel are also trained in how to respond to short-term, long-term and large-scale emergencies. Laboratory security can play a role in reducing the likelihood of some emergencies and assisting in preparation and response for others. Every institution, department, and individual laboratory should consider having an emergency preparedness plan. The level of detail of the plan will vary depending on the function of the group and institutional planning efforts already in place. 
Emergency planning is a dynamic process. As personnel, operations, and events change, plans will need to be updated and modified. To determine the type and level of emergency planning needed, laboratory personnel need to perform a vulnerability assessment. Periodic drills to assist in training and evaluation of the emergency plan are recommended as part of the training program. 
H. Emergency Procedures 
(1) Fire alarm policy. Most organizations use fire alarms whenever a building needs to be evacuated - for any reason. When a fire alarm sounds in the facility, evacuate immediately after extinguishing all equipment flames. Check on and assist others who may require help evacuating. 
(2) Emergency safety equipment. The following safety elements should be met: 
a. A written emergency action plan has been provided to workers; 
b. Fire extinguishers, eyewash units, and safety showers are available and tested on a regular basis; and 
c. Fire blankets, first-aid equipment, fire alarms, and telephones are available and accessible. 
(3) Chemical spills. Workers should contact the CHO or EHS office for instructions before cleaning up a chemical spill. All SDS and label instructions should be followed, and appropriate PPE should be worn during spill cleanup. 
(4) Accident procedures. In the event of an accident, immediately notify appropriate personnel and local emergency responders. Provide an SDS of any chemical involved to the attending physician. Complete an accident report and submit it to the appropriate office or individual within 24 hours. 
(5) Employee safety training program. New workers should attend safety training before they begin any activities. Additional training should be provided when they advance in their duties or are required to perform a task for the first time. Training documents should be recorded and maintained. Training should include hands-on instruction of how to use safety equipment appropriately. 
(6) Conduct drills. Practice building evacuations, including the use of alternate routes. Practice shelter-in-place, including plans for extended stays. Walk the fastest route from your work area to the nearest fire alarm, emergency eye wash and emergency shower. Learn how each is activated. In the excitement of an actual emergency, people rely on what they learned from drills, practice and training. 
(7) Contingency plans. All laboratories should have long-term contingency plans in place (e.g., for pandemics). Scheduling, workload, utilities and alternate work sites may need to be considered. 
I. Laboratory Security 
Laboratory security has evolved in the past decade, reducing the likelihood of some emergencies and assisting in preparation and response for others. Most security measures are based on the laboratory's vulnerability. Risks to laboratory security include, but are not limited to: 
(1) Theft or diversion of chemicals, biologicals, and radioactive or proprietary materials, mission-critical or high-value equipment; 
(2) Threats from activist groups; 
(3) Intentional release of, or exposure to, hazardous materials; 
(4) Sabotage or vandalism of chemicals or high-value equipment; 
(5) Loss or release of sensitive information; and 
(6) Rogue work or unauthorized laboratory experimentation. Security systems in the laboratory are used to detect and respond to a security breach, or a potential security breach, as well as to delay criminal activity by imposing multiple layered barriers of increasing stringency. A good laboratory security system will increase overall safety for laboratory personnel and the public, improve emergency preparedness by assisting with preplanning, and lower the organization's liability by incorporating more rigorous planning, staffing, training, and command systems and implementing emergency communications protocols, drills, background checks, card access systems, video surveillance, and other measures. The security plan should clearly delineate response to security issues, including the coordination of institution and laboratory personnel with both internal and external responders. 
Appendix B to § 1910.1450 - References (Non-Mandatory) 
The following references are provided to assist the employer in the development of a Chemical Hygiene Plan. The materials listed below are offered as non-mandatory guidance. References listed here do not imply specific endorsement of a book, opinion, technique, policy or a specific solution for a safety or health problem. Other references not listed here may better meet the needs of a specific laboratory. (a) Materials for the development of the Chemical Hygiene Plan: 
1. American Chemical Society, Safety in Academic Chemistry Laboratories, 4th edition, 1985. 
2. Fawcett, H.H. and W. S. Wood, Safety and Accident Prevention in Chemical Operations, 2nd edition, Wiley-Interscience, New York, 1982. 
3. Flury, Patricia A., Environmental Health and Safety in the Hospital Laboratory, Charles C. Thomas Publisher, Springfield IL, 1978. 
4. Green, Michael E. and Turk, Amos, Safety in Working with Chemicals, Macmillan Publishing Co., NY, 1978. 
5. Kaufman, James A., Laboratory Safety Guidelines, Dow Chemical Co., Box 1713, Midland, MI 48640, 1977. 
6. National Institutes of Health, NIH Guidelines for the Laboratory use of Chemical Carcinogens, NIH Pub. No. 81-2385, GPO, Washington, DC 20402, 1981. 
7. National Research Council, Prudent Practices for Disposal of Chemicals from Laboratories, National Academy Press, Washington, DC, 1983. 
8. National Research Council, Prudent Practices for Handling Hazardous Chemicals in Laboratories, National Academy Press, Washington, DC, 1981. 
9. Renfrew, Malcolm, Ed., Safety in the Chemical Laboratory, Vol. IV, J. Chem. Ed., American Chemical Society, Easlon, PA, 1981. 
10. Steere, Norman V., Ed., Safety in the Chemical Laboratory, J. Chem. Ed. American Chemical Society, Easlon, PA, 18042, Vol. I, 1967, Vol. II, 1971, Vol. III 1974. 
11. Steere, Norman V., Handbook of Laboratory Safety, the Chemical Rubber Company Cleveland, OH, 1971. 
12. Young, Jay A., Ed., Improving Safety in the Chemical Laboratory, John Wiley & Sons, Inc. New York, 1987. 
(b) Hazardous Substances Information: 
1. American Conference of Governmental Industrial Hygienists, Threshold Limit Values for Chemical Substances and Physical Agents in the Workroom Environment with Intended Changes, 6500 Glenway Avenue, Bldg. D-7 Cincinnati, OH 45211-4438 (latest edition). 
2. Annual Report on Carcinogens, National Toxicology Program U.S. Department of Health and Human Services, Public Health Service, U.S. Government Printing Office, Washington, DC, (latest edition). 
3. Best Company, Best Safety Directory, Vols. I and II, Oldwick, N.J., 1981. 
4. Bretherick, L., Handbook of Reactive Chemical Hazards, 2nd edition, Butterworths, London, 1979. 
5. Bretherick, L., Hazards in the Chemical Laboratory, 3rd edition, Royal Society of Chemistry, London, 1986. 
6. Code of Federal Regulations, 29 CFR part 1910 subpart Z. U.S. Govt. Printing Office, Washington, DC 20402 (latest edition). 
7. IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man, World Health Organization Publications Center, 49 Sheridan Avenue, Albany, New York 12210 (latest editions). 
8. NIOSH/OSHA Pocket Guide to Chemical Hazards. NIOSH Pub. No. 85-114, U.S. Government Printing Office, Washington, DC, 1985 (or latest edition). 
9. Occupational Health Guidelines, NIOSH/OSHA NIOSH Pub. No. 81-123 U.S. Government Printing Office, Washington, DC, 1981. 
10. Patty, F.A., Industrial Hygiene and Toxicology, John Wiley & Sons, Inc., New York, NY (Five Volumes). 
11. Registry of Toxic Effects of Chemical Substances, U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, Revised Annually, for sale from Superintendent of Documents U.S. Govt. Printing Office, Washington, DC 20402. 
12. The Merck Index: An Encyclopedia of Chemicals and Drugs. Merck and Company Inc. Rahway, N.J., 1976 (or latest edition). 
13. Sax, N.I. Dangerous Properties of Industrial Materials, 5th edition, Van Nostrand Reinhold, NY., 1979. 
14. Sittig, Marshall, Handbook of Toxic and Hazardous Chemicals, Noyes Publications, Park Ridge, NJ, 1981. 
(c) Information on Ventilation: 
1. American Conference of Governmental Industrial Hygienists Industrial Ventilation (latest edition), 6500 Glenway Avenue, Bldg. D-7, Cincinnati, Ohio 45211-4438. 
2. American National Standards Institute, Inc. American National Standards Fundamentals Governing the Design and Operation of Local Exhaust Systems ANSI Z 9.2-1979 American National Standards Institute, N.Y. 1979. 
3. Imad, A.P. and Watson, C.L. Ventilation Index: An Easy Way to Decide about Hazardous Liquids, Professional Safety pp 15-18, April 1980. 
4. National Fire Protection Association, Fire Protection for Laboratories Using Chemicals NFPA-45, 1982. 
Safety Standard for Laboratories in Health Related Institutions, NFPA, 56c, 1980. 
Fire Protection Guide on Hazardous Materials, 7th edition, 1978. 
National Fire Protection Association, Batterymarch Park, Quincy, MA 02269. 
5. Scientific Apparatus Makers Association (SAMA), Standard for Laboratory Fume Hoods, SAMA LF7-1980, 1101 16th Street, NW., Washington, DC 20036. 
(d) Information on Availability of Referenced Material: 
1. American National Standards Institute (ANSI), 1430 Broadway, New York, NY 10018. 
2. American Society for Testing and Materials (ASTM), 1916 Race Street, Philadelphia, PA 19103.
[55 FR 3327, Jan. 31, 1990; 55 FR 7967, Mar. 6, 1990; 55 FR 12111, Mar. 30, 1990; 57 FR 29204, July 1, 1992; 61 FR 5508, Feb. 13, 1996; 71 FR 16674, Apr. 3, 2006; 76 FR 33609, June 8, 2011; 77 FR 17887, Mar. 26, 2012; 78 FR 4325, Jan. 22, 2013]


