
[Federal Register: March 3, 2008 (Volume 73, Number 42)]
[Notices]               
[Page 11408-11410]
From the Federal Register Online via GPO Access [wais.access.gpo.gov]
[DOCID:fr03mr08-54]                         

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ENVIRONMENTAL PROTECTION AGENCY

[FRL-8536-2; Docket ID No. EPA-HQ-ORD-2008-0048]

 
Draft Toxicological Review of 2-Hexanone: In Support of the 
Summary Information in the Integrated Risk Information System (IRIS)

AGENCY: Environmental Protection Agency (EPA).

ACTION: Notice of public comment period.

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SUMMARY: EPA is announcing the public review and comment period for the 
external review draft document titled, ``Toxicological Review of 2-
Hexanone: In Support of Summary Information on the Integrated Risk 
Information System (IRIS)'' (NCEA-S-2764). The EPA intends to consider 
comments and recommendations from the public and an expert panel 
meeting, which will be

[[Page 11409]]

scheduled at a later date and announced in the Federal Register, when 
EPA finalizes the draft document. The public comment period will 
provide opportunities for all interested parties to comment on the 
document. EPA intends to forward public comments, submitted in 
accordance with this notice, to the external peer-review panel prior to 
the workshop for their consideration.
    EPA is releasing this draft document solely for the purpose of pre-
dissemination peer review under applicable information quality 
guidelines. This document has not been formally disseminated by EPA. It 
does not represent and should not be construed to represent any Agency 
policy or determination.
    The draft document is available via the Internet on NCEA's home 
page under the Recent Additions and the Data and Publications menus at 
http://www.epa.gov/ncea. When finalizing the draft document, EPA 
intends to consider any public comments that EPA receives in accordance 
with this notice.

DATES: The public comment period begins February 28, 2008, and ends 
April 28, 2008. Technical comments should be in writing and must be 
received by EPA by April 28, 2008. EPA intends to submit comments from 
the public received by this date to the external peer-review panel.

ADDRESSES: The draft Toxicological Review of 2-Hexanone: In Support of 
Summary Information on the Integrated Risk Information System (IRIS) is 
available via the Internet on the National Center for Environmental 
Assessment's (NCEA) home page under the Recent Additions and the Data 
and Publications menus at http://www.epa.gov/ncea. A limited number of 
paper copies are available from NCEA's Technical Information Staff; 
telephone: 703-347-8561; facsimile: 703-347-8691. If you are requesting 
a paper copy, please provide your name, mailing address, and the 
document title.
    Comments may be submitted electronically via http://
www.regulations.gov, by mail, by facsimile, or by hand delivery/
courier. Please follow the detailed instructions as provided in the 
SUPPLEMENTARY INFORMATION section of this notice.

FOR FURTHER INFORMATION CONTACT: For information on the public comment 
period, contact the Office of Environmental Information Docket; 
telephone: 202-566-1752; facsimile: 202-566-1753; or e-mail: 
ORD.Docket@epa.gov.
    If you have questions about the draft document, contact Amanda 
Persad, IRIS Staff, National Center for Environmental Assessment, 109 
T.W. Alexander Dr., Research Triangle Park, NC, 27709; telephone: 919-
541-9781; facsimile: 919-541-1818; or e-mail: persad.amanda@epa.gov.

SUPPLEMENTARY INFORMATION:

I. Summary of Information About the Integrated Risk Information System 
(IRIS)

    IRIS is a database that contains potential adverse human health 
effects information that may result from chronic (or lifetime) exposure 
to specific chemical substances found in the environment. The database 
(available on the Internet at http://www.epa.gov/iris) contains 
qualitative and quantitative health effects information for more than 
540 chemical substances that may be used to support the first two steps 
(hazard identification and dose-response evaluation) of a risk 
assessment process. When supported by available data, the database 
provides oral reference doses (RfDs) and inhalation reference 
concentrations (RfCs) for chronic health effects, and oral slope 
factors and inhalation unit risks for carcinogenic effects. Combined 
with specific exposure information, government and private entities can 
use IRIS data to help characterize public health risks of chemical 
substances in a site-specific situation and thereby support risk 
management decisions designed to protect public health.

II. How To Submit Technical Comments to the Docket at http://
www.regulations.gov

    Submit your comments, identified by Docket ID No. EPA-HQ-ORD-2008-
0048 by one of the following methods:
     http://www.regulations.gov: Follow the on-line 
instructions for submitting comments.
     E-mail: ORD.Docket@epa.gov.
     Fax: 202-566-1753.
     Mail: Office of Environmental Information (OEI) Docket 
(Mail Code: 2822T), U.S. Environmental Protection Agency, 1200 
Pennsylvania Ave., NW., Washington, DC 20460. The phone number is 202-
566-1752.
     Hand Delivery: The OEI Docket is located in the EPA 
Headquarters Docket Center, EPA West Building, Room 3334, 1301 
Constitution Ave., NW., Washington, DC. The EPA Docket Center Public 
Reading Room is open from 8:30 a.m. to 4:30 p.m., Monday through 
Friday, excluding legal holidays. The telephone number for the Public 
Reading Room is 202-566-1744. Such deliveries are only accepted during 
the docket's normal hours of operation, and special arrangements should 
be made for deliveries of boxed information.
    If you provide comments by e-mail or hand delivery, please submit 
one unbound original with pages numbered consecutively, and three 
copies of the comments. For attachments, provide an index, number pages 
consecutively with the comments, and submit an unbound original and 
three copies.
    Instructions: Direct your comments to Docket ID No. EPA-HQ-ORD-
2008-0048. Please ensure that your comments are submitted within the 
specified comment period. Comments received after the closing date will 
be marked ``late,'' and may only be considered if time permits. It is 
EPA's policy to include all comments it receives in the public docket 
without change and to make the comments available online at http://
www.regulations.gov, including any personal information provided, 
unless a comment includes information claimed to be Confidential 
Business Information (CBI) or other information whose disclosure is 
restricted by statute. Do not submit information that you consider to 
be CBI or otherwise protected through http://www.regulations.gov or e-
mail. The http://www.regulations.gov Web site is an ``anonymous 
access'' system, which means EPA will not know your identity or contact 
information unless you provide it in the body of your comment. If you 
send an e-mail comment directly to EPA without going through http://
www.regulations.gov, your e-mail address will be automatically captured 
and included as part of the comment that is placed in the public docket 
and made available on the Internet. If you submit an electronic 
comment, EPA recommends that you include your name and other contact 
information in the body of your comment and with any disk or CD-ROM you 
submit. If EPA cannot read your comment due to technical difficulties 
and cannot contact you for clarification, EPA may not be able to 
consider your comment. Electronic files should avoid the use of special 
characters, any form of encryption, and be free of any defects or 
viruses. For additional information about EPA's public docket visit the 
EPA Docket Center homepage at http://www.epa.gov/epahome/dockets.htm.
    Docket: All documents in the docket are listed in the http://
www.regulations.gov index. Although listed in the index, some 
information is not publicly available, e.g., CBI or other information 
whose disclosure is restricted by statute. Certain other material, such 
as copyrighted material, will be publicly available only in hard copy. 
Publicly available docket

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materials are available either electronically in http://
www.regulations.gov or in hard copy at the OEI Docket in the EPA 
Headquarters Docket Center.

    Dated: February 21, 2008.
Rebecca Clark,
Deputy Director, National Center for Environmental Assessment.
[FR Doc. E8-4051 Filed 2-29-08; 8:45 am]

BILLING CODE 6560-50-P
