Organophosphate
Pesticides
Overview
Anna
Lowit,
Ph.
D.

Anna
Lowit,
Ph.
D.

U.
S.
EPA
U.
S.
EPA
Office
of
Pesticide
Programs
Office
of
Pesticide
Programs
April
5,
2006
April
5,
2006
Common
Mechanism
Group:

Common
Mechanism
Group:

Organophosphate
Pesticides
Organophosphate
Pesticides

Inhibition
of
AChE
by
phosphorylation:

°
Brain
°
Peripheral
nervous
system
(
e.
g.,
nerves
in
diaphragm,
muscles)

°
Surrogate/
Indicator
(
RBC,
Plasma)

U.
S.
EPA
1999
Policy
Paper
Issues
for
HSRB
Issues
for
HSRB

Scientific
conduct
&
study
design

Ethical
conduct

Azinphos­
methyl:


Worker
risk
assessment
and
cumulative
risk
assessment

DDVP:


Single
chemical
aggregate
and
cumulative
risk
assessment
