September 26  --  December 13, 2013
Peer Review Meeting of Methylene Chloride (CASRN 75-09-2)-DCM 
and N-Methylpyrrolidone (CASRN 872-50-4)-NMP 


                 BIOSKETCHES FOR DCM-NMP PEER REVIEW PANELISTS
Dr. Gary Ginsberg (Chair) is a toxicologist at the Connecticut Department of Public Health within the Division of Environmental and Occupational Health Assessment. He has responsibility for human health risk assessments conducted within the state government. Dr. Ginsberg serves as adjunct faculty at the Yale School of Public Health and is an Assistant Clinical Professor at the University of Connecticut School of Community Medicine. He is currently a member of the National Academy of Sciences committee reviewing inorganic arsenic and served on two previous NAS committees (Human Biomonitoring, 2007; USEPA Risk Methods which produced Science and Decisions, 2009). He was first author of a manuscript that won best paper of the year award from the Society of Toxicology Risk Assessment Specialty Section, 2009. Dr. Ginsberg was a member of USEPA's Children's Health Protection Advisory Committee until 2009 and is currently a member of USEPA's Science Advisory Board. He has participated on expert review panels for state governments in Minnesota, New Jersey, California and Massachusetts. He was an Oak Ridge Institute for Science and Education (ORISE) fellow with USEPA's National Center for Environmental Assessment from 2010 to 2012. He has published in the areas of early life stage vulnerability, pharmacokinetic modeling, genetic polymorphisms, metabolism in aging populations, fish consumption advisories and environmental risk assessment. Dr. Ginsberg's toxicology experience has involved a variety of settings: basic research, teaching, working within the pesticide and consulting industries, and now working in public health. Dr. Ginsberg is also co-author of a book on toxics for the lay public, "What's Toxic, What's Not:" Berkley Books, December 2006.
Dr. Thomas W. Armstrong is the Principal Investigator since 2008 at his sole proprietor consulting company, TWA8HR Occupational Hygiene Consulting, LLC. Dr. Armstrong received his B.A. in Chemistry, M.S. in Environmental Health, and Ph.D. in Environmental Engineering, all from Drexel University in Philadelphia, Pennsylvania. He currently has an Adjunct Professor appointment at the Drexel University School of Public Health. Before he retired from ExxonMobil Biomedical Sciences in 2008, his last position there was as Senior Scientific Associate in Exposure Sciences. While at ExxonMobil, he developed exposure assessment strategies for and provided support to multiple epidemiology studies, including work under contract to the University of Colorado to support multiple general population epidemiology investigations in Shanghai, China. Also, while at ExxonMobil, Dr. Armstrong served on the company's internal occupational exposure limit committee and published a method for adjusting exposure limits to extended work schedules. His ongoing research activities include exposure assessment for epidemiology studies, mathematical methods to estimate exposures to chemicals and quantitative risk assessments for Legionella and Legionnaires' disease. He has 30 peer reviewed publications, has contributed multiple chapters to three books and has provided peer reviews to eight journals. Dr. Armstrong has presented on diverse topics at symposia in the United States and abroad. He was the lead instructor for American Industrial Hygiene Association (AIHA) professional development courses on mathematical modeling to assess chemical exposures, and Monte Carlo Simulation techniques in exposure assessment, and has taught in other courses, including a review of toxicology for industrial hygienists. He remains active in AIHA risk assessment, epidemiology and exposure assessment committee activities. Dr. Armstrong was a member of two National Academy of Sciences committees that conducted reviews of and completed reports on risk assessments for two national biocontainment laboratories. In addition, he provided support to a National Institute for Occupational Safety and Health (NIOSH) review of the institute's occupational exposure assessment strategy, and served on a NIOSH National Occupational Research Agenda committee. He also participated in several panels on EPA children's health issues. 
Dr. Frank A. Barile is Professor of Applied and Clinical Toxicology in the Department of Pharmaceutical Sciences, St. John's University College of Pharmacy and Health Sciences, New York. He received his Ph.D. in Toxicology (1982) at St. John's University. He completed post-doctoral fellowships at the Albert Einstein College of Medicine, Bronx, NY, and Columbia University, NY. In 1984, he was appointed Assistant Professor in the Department of Health Sciences at City University of NY. Sixteen years later he rejoined St. John's University in the Department of Pharmaceutical Sciences. Dr. Barile holds memberships in the U.S. Society of Toxicology, the American Association for the Advancement of Science, and the New York Academy of Sciences. He was elected President of the In Vitro & Alternative Methods Specialty Section of the U.S. Society of Toxicology (2005-2008) and was recently elected VP-elect for the Dermal Toxicology Specialty Section (2013-2014), followed by President. He is the recipient of the U.S. Public Health Service Medallion from the Director of the NIEHS, Dr. Linda Birnbaum (June, 2009). Dr. Barile is the recipient of PHS research grants from the National Institutes of Health (NIGMS) for the last 20 years, as well as from the Alternative Research & Development Foundation (Jenkinton, PA) and the International Foundation for Ethical Research (Chicago, IL). Dr. Barile has authored approximately 75 papers and abstracts in peer-reviewed biomedical and toxicology journals, as well as five books and three chapters, including Clinical Toxicology: Principles and Mechanisms, 2nd edition, 2010 (Informa HealthCare, UK) and Principles of Toxicology Testing, 2nd edition, 2013 (CRC Press, FL). Recently published articles describe the development of in vitro ocular toxicity testing methods for detecting irritant and corrosive properties of chemicals (J. Pharmacological Toxicological Methods, 2010) and highlight epigenetic mechanisms using trace metals in embryonic stem cells (Toxicology Letters, 2012). Dr. Barile serves on the editorial boards of Toxicology In Vitro (2007-present) and J. Pharmacological & Toxicological Methods (2008-present). He is currently Editor-in-Chief of Toxicology In Vitro (2012-present). He continues fundamental research on the cytotoxic effects of environmental chemicals on cultured human and mammalian embryonic stem cells.
Dr. Anneclaire J. De Roos is Associate Professor of Environmental and Occupational Health in the Drexel University School of Public Health in Philadelphia, Pennsylvania. She earned a bachelor of arts degree (geography/ecosystems) from the University of California at Los Angeles, a master of public health (MPH) degree (epidemiology/biostatistics) from the University of California at Berkeley, and a PhD (epidemiology) in the year 2000 from the University of North Carolina at Chapel Hill. Her research interests and experience are primarily in the study of occupational and environmental exposures to chemicals and radiation as risk factors for cancer, autoimmune diseases, and intermediate biologic effects. Dr. De Roos' dissertation research focused on parental occupational exposures as risk factors for childhood cancer in their offspring. From 2000-2002, Dr. De Roos trained as a postdoctoral fellow in the Division of Cancer Epidemiology and Genetics of the National Cancer Institute, where she gained experience in studies of genetic determinants of disease and intermediate biologic effects (immune function, inflammation) of environmental exposures. She was a member of the faculty at the University of Washington (UW) and Fred Hutchinson Cancer Research Center in Seattle, WA from 2003-2012, where her research focused on environmental risk factors for non-Hodgkin lymphoma, leukemias, and other cancers, including workplace exposures (pesticides, solvents), persistent organic pollutants (PCBs, dioxins), and point sources of pollution (industrial facilities, traffic). Dr. De Roos has been a member of the International Lymphoma Epidemiology (InterLymph) Consortium since 2005, and is currently funded by the National Institute of Environmental Health Sciences (NIEHS) to conduct a consortium-based evaluation of occupational solvent exposure as a potential cause of multiple myeloma. At the UW, Dr. De Roos taught courses in cancer epidemiology, environmental and occupational epidemiology, public health in the media, and advanced epidemiologic methods. In her current position at Drexel, Dr. De Roos is developing a new masters' level course in environmental risk assessment. She serves as a frequent reviewer for occupational and environmental health journals, most notably as an editorial review board member for Environmental Health Perspectives. She has published over 90 refereed research articles, authored 7 book chapters, and made numerous invited presentations at national and international conferences. Dr. De Roos has also served on several expert committees in recent years, including those reviewing formaldehyde for NIEHS's Report on Carcinogens and the trichloroethylene (TCE) health assessment document for the Environmental Protection Agency.
Dr. Ronald D. Hood is Principal of Ronald D. Hood and Associates, Toxicology Consultants. He also is Professor Emeritus of Biological Sciences, having retired from the faculty of the Cell, Molecular, and Developmental Biology Section of the Department of Biological Sciences of the University of Alabama after 32 years of service, and he has been an Adjunct Professor of Public Health, School of Public Health, University of Alabama at Birmingham. Dr. Hood received his Ph.D. from Purdue University in 1969 in Reproductive Physiology and joined the faculty of the University of Alabama as an Assistant Professor. He was promoted to the rank of Professor by 1978, and he also served as Interim Department Chair from July 1996 to August, 1997. In addition, Dr. Hood was Consultant in Environmental Medicine for the U.S. Veterans Administration, Office of Medicine and Surgery, Agent Orange Special Projects Office (off site), during 1983, and a Special Consultant, Science Advisory Board, EPA, from 1983 through 1993. He has served as a consultant to pharmaceutical, chemical, and biotech companies, trade associations, federal and state regulatory agencies, and law firms since 1978. Dr. Hood presented toxicology training courses to regulatory personnel of Health Canada annually from 2006 to 2011. Dr. Hood has served as a member of the editorial boards of Fundamental and Applied Toxicology and Toxicological Sciences, and he was an ad hoc member of EPA's Food Quality Protection Act Science Review Board. Dr. Hood has participated in workshops and expert panels to provide expertise on developmental toxicity and risk assessment, and he was inducted as a Fellow of the Academy of Toxicological Sciences. Dr. Hood has authored, coauthored or edited more than 100 publications (research articles, book chapters and books) in the areas of developmental and reproductive toxicology. Dr. Hood's most recent edited book is Developmental and Reproductive Toxicology, a Practical Approach, Third Edition, published in 2012, by the Informa Healthcare division of CRC Press. Dr. Hood has been active in the Teratology Society, chairing the Membership, Education, Constitution/Bylaws, and Website committees. He also has been active in the Reproductive and Developmental Toxicology Specialty Section of the Society of Toxicology, and he has served as their newsletter editor.
Dr. Dale Hattis is a Research Professor at the George Perkins Marsh Institute at Clark University in Worcester, Massachusetts, with a B.A. in Biochemistry from the University of California, Berkeley (1967), and a Ph.D. in Genetics from Stanford University (1974). For the past 39 years Dr. Hattis has been engaged in the development and application of methodology to assess the health, ecological and economic impacts of regulatory actions. His work has focused on the development of methodology to incorporate interindividual variability data and quantitative mechanistic information into risk assessments for both cancer and noncancer endpoints, and he has published more than 200 technical papers, including on physiologically based pharmacokinetic modeling. Specific studies have included pharmacokinetic modeling and risks from developmental effects of the organophosphate insecticide chlorpyrifos, dosimetric uncertainties in epidemiological information on dioxin cancer risks, age-related differences in pharmacokinetic processes and susceptibility for carcinogenesis, renal effects of cadmium, reproductive effects of ethoxyethanol, neurological and cardiovascular effects of methyl mercury, neurological effects of acrylamide, chronic lung function impairment from coal dust, four pharmacokinetic-based risk assessments for carcinogens (for perchloroethylene, ethylene oxide, butadiene and diesel particulates), an analysis of uncertainties in pharmacokinetic modeling for perchloroethylene, and an analysis of differences among species in processes related to carcinogenesis. He currently is a member of the National Toxicology Program Board of Scientific Counselors. In the past, he has served as a member of the Environmental Health Committee of the Environmental Protection Agency's Science Advisory Board, and as a member of the Food Quality Protection Act Science Review Board. He has been a councilor and is a Fellow of the Society for Risk Analysis.
Dr. John C. Kissel is currently Professor of Environmental and Occupational Health Sciences at the University of Washington in Seattle, where he has been a member of the faculty since 1990. He held a prior position in the School of Public and Environmental Affairs at Indiana University. Dr. Kissel holds a Ph.D. in Civil/Environmental Engineering from Stanford University and is a registered professional engineer. Dr. Kissel's research interests generally involve human exposure assessment, with emphasis on exposures related to waste management, agricultural and residential use of pesticides, and consumer products. He is particularly interested in probabilistic prediction of aggregate exposure and reconciliation of model predictions with observed biomarker data. Dr. Kissel and his students have produced multiple papers describing human exposure to soil that are listed as "key studies" in US EPA's Exposure Factors Handbook. Dr. Kissel is a former President and Councilor of the International Society of Exposure Science and also served one term as chair of the Exposure Assessment Specialty Group within the Society for Risk Analysis. He was a member of a National Academy of Sciences Committee that evaluated Superfund-related remediation of mining and smelting related contamination in the Coeur d'Alene Basin in Idaho and a reviewer of the WHO environmental health criteria document on Dermal Exposure, which will be published soon. Dr. Kissel has served as an ad hoc member of US EPA's FIFRA Science Advisory Panel on multiple occasions and is currently a member of EPA's Human Studies Review Board. His recent research activities have been funded by US EPA, US DOE, NIOSH and the Washington State Departments of Ecology and Health. 
Dr. Stephen B. Pruett is Professor of Immunotoxicology and Head of the Department of Basic Sciences at the College of Veterinary Medicine, Mississippi State University. He earned his B.S. degree from Northwestern State University of Louisiana (Microbiology) and his Ph.D. degree from Louisiana State University School of Medicine in Shreveport (Immunology). He had post-doctoral training at the University of Alabama of Birmingham School of Medicine (Immunology) with Dr. J. Claude Bennett, and received training in toxicology and pharmacology during a Sabbatical with Dr. Albert E. Munson at the Medical College of Virginia. Dr. Pruett began his academic research career as an assistant professor in the Department of Biological Sciences at Mississippi State University and left at the rank of professor after 13 years to take a similar position at the LSU Health Sciences Center in Shreveport. He returned to Mississippi State University in his current position after 10 years at LSU. His research interests include the effects of drugs, chemicals, and stress on the immune system. He has a long interest in pesticides, drugs of abuse, and psychological stressors and has been funded by the National Institutes of Health (NIH) for work in each of these areas. He is currently a member of the Innate Immunity and Inflammation Study Section for NIH and has served as a frequent ad hoc grant reviewer for several other NIH study sections beginning in 1990. He serves on the editorial boards of two leading toxicology journals, Toxicological Sciences and Toxicology and Applied Pharmacology, and recently served several years as an Associate Editor for the Journal of Immunology. He has served in several leadership positions in the Society of Toxicology, including President of the South Central Chapter and President of the Immunotoxicology Specialty Section. He is a Fellow of the Academy of Toxicological Sciences and a member of the American College of Toxicologists. He has published more than 115 peer-reviewed manuscripts and 10 book chapters, and has been an invited speaker at numerous meetings in the U.S., Australia, Europe, and Japan.

