August
6,
2003
National
Advisory
Council
for
Environmental
Policy
and
Technology
(
NACEPT)
Endocrine
Disruptor
Methods
Validation
Subcommittee
(
EDMVS)
Plenary
Meeting
August
18
 
20,
2003
Table
Mountain
Inn
1310
Washington
Avenue
Golden,
CO
80401
(
303)
216­
8040
Proposed
Agenda
Meeting
Objectives:

1.
Review
and
discuss
the
status/
results
of
the
prevalidation
work
on:
 
the
fish
screening
assay,
specifically:
the
survey
of
vitellogenin
methods
in
Fathead
Minnow,
Zebrafish
and
Medaka;
the
comparative
evaluation
of
the
Fathead
Minnow
assays;
and
the
Fish
Screen
(
non­
spawning)
assay;
and
 
the
steroidogenesis
assay
optimized
protocol.
2.
Provide
input
and
advice
on
the:
 
EDSP's
validation
plans
for
the
fish
screening
assay
and
steroidogenesis
assay;
 
strain/
species
white
paper;
 
chemicals
used
in
EDSP's
prevalidation
and
validation.
 
avian
detailed
review
paper;
and
 
issues
related
to
the
pubertal
assays.
3.
Receive
an
update
on
the
amphibian
workshop
conducted
recently.

Monday,
August
18,
2003
1:
30
 
1:
40
Welcome
and
Opening
Comments
Joe
Merenda,
EDMVS
Chair
and
Director,
Office
of
Science
Coordination
and
Policy
(
OSCP),
EPA
1:
40
 
2:
00
Introduction,
Agenda
Review,
and
Review
of
Previous
Meeting
Summary
Paul
De
Morgan,
Facilitator,
RESOLVE
2:
00
 
2:
30
Review
of
EDMVS
Work
Plan
Jane
Smith,
EDMVS
Designated
Federal
Official,
OSCP,
EPA
2:
30
 
3:
45
Presentation
on
Fish
Screening
Assays:

Results
of
the
Survey
of
Vitellogenin
Methods
in
Fathead
Minnow

Results
of
the
Survey
of
Vitellogenin
Methods
in
Zebrafish
and
Medaka
Michael
Blanton,
Battelle
3:
45
 
4:
00
Break
4:
00
 
4:
45
Presentation
on
Fish
Screening
Assay:
Results
of
the
Comparative
Evaluation
of
the
Fathead
Minnow
Dr.
Irvin
Schultz,
Battelle
1
August
6,
2003
4:
45
 
5:
15
Presentation
on
OECD
Phase
1A:
Feasibility
to
Demonstrate
the
Fish
Screen
(
Nonspawning)
Method
Dr.
Hirofumi
Yokota,
Chemicals
Evaluation
and
Research
Institute
(
CERI),
Japan
5:
15
 
5:
45
Public
Comment
Members
of
the
public
will
be
given
an
opportunity
to
comment
on
any
aspect
of
the
EDMVS
work.
The
amount
of
time
given
to
each
individual
will
depend
on
the
number
of
people
wishing
to
provide
comment.

5:
45
Adjourn
Tuesday,
August
19,
2003
7:
45
 
8:
00
Settling
In
8:
00
 
9:
30
Discussion
of
the
Fish
Screening
Assay
9:
30
 
10:
00
Overview
of
Amphibian
Workshop
Dr.
Les
Touart,
OSCP,
EPA
10:
00
 
10:
15
Break
10:
15
 
12:
30
Presentation
and
Discussion
on
Strain/
Species
Dr.
Sherry
Parker,
Research
Triangle
Institute
(
RTI)
Dr.
Jimmy
Spearow,
AFFILIATION?

12:
30
 
1:
30
Lunch
1:
30
 
2:
30
Update
on
Chemicals
Used
for
EDSP's
Prevalidation
and
Validation
Gary
Timm,
OSCP,
EPA
2:
30
Adjourn
Wednesday,
August
20,
2003
8:
00
 
8:
15
Settling
In
8:
15
 
10:
15
Presentation
and
Discussion
of
Avian
Detailed
Review
Paper
Dr.
Les
Touart,
OSCP,
EPA
10:
15
 
10:
30
Break
10:
30
 
12:
00
Issues
Related
to
the
Pubertal
Assay
Dr.
L.
Earl
Gray,
Office
of
Research
and
Development,
EPA
12:
00
 
1:
00
Lunch
1:
00
 
1:
30
Presentation
on
Steroidogenesis
Assay
Optimized
Protocol
Carol
Sloan,
RTI
2
August
6,
2003
3
1:
30
 
2:
30
Presentation
and
Discussion
on
Steroidogenesis
Prevalidation
Study
Plan
Gary
Timm,
OSCP,
EPA
2:
30
 
2:
45
Break
2:
45
 
3:
15
Public
Comment
Members
of
the
public
will
be
given
an
opportunity
to
comment
on
any
aspect
of
the
EDMVS
work.
The
amount
of
time
given
to
each
individual
will
depend
on
the
number
of
people
wishing
to
provide
comment
3:
15
 
3:
30
Next
Steps
and
Agenda
for
Next
Meeting
3:
30
Adjourn
