Tuesday,

July
30,
2002
Part
V
Environmental
Protection
Agency
Fiftieth
Report
of
the
TSCA
Interagency
Testing
Committee
to
the
Administrator
of
the
Environmental
Protection
Agency;
Receipt
of
Report
and
Request
for
Comments;
Notice
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RECEIVED
OPPT
NCIC
2003
JUN­
9
2:
29PM
OPPT­
2003­
0026­
0004
49530
Federal
Register
/
Vol.
67,
No.
146
/
Tuesday,
July
30,
2002
/
Notices
ENVIRONMENTAL
PROTECTION
AGENCY
[
OPPT
 
2002
 
0026;
FRL
 
7183
 
7]

Fiftieth
Report
of
the
TSCA
Interagency
Testing
Committee
to
the
Administrator
of
the
Environmental
Protection
Agency;
Receipt
of
Report
and
Request
for
Comments
AGENCY:
Environmental
Protection
Agency
(
EPA).
ACTION:
Notice.

SUMMARY:
The
Toxic
Substances
Control
Act
(
TSCA)
Interagency
Testing
Committee
(
ITC)
transmitted
its
50th
ITC
Report
to
the
Administrator
of
EPA
on
May
28,
2002.
In
the
50th
ITC
Report,
which
is
included
with
this
notice,
the
ITC
is
rescinding
its
request
in
the
48th
ITC
Report
to
EPA
for
the
addition
to
the
TSCA
section
8(
a)
Preliminary
Assessment
Information
Reporting
(
PAIR)
rule
of
12
of
the
15
Degradation
Effects
Bioconcentration
Information
Testing
Strategies
(
DEBITS)
chemicals.
However,
the
ITC
is
asking
EPA
to
add
3
chemicals
to
the
PAIR
rule
and
3
chemicals
to
the
TSCA
section
8(
d)
Health
and
Safety
Data
Reporting
(
HaSDR)
rule.
The
ITC
is
adding
2
chemicals
and
removing
36
chemicals
from
the
Priority
Testing
List.
The
ITC
is
soliciting
comments
on
its
Voluntary
Information
Submissions
Innovative
Online
Network
(
VISION)
and
Voluntary
Information
Submissions
Policy
(
VISP).
DATES:
Comments,
identified
by
docket
ID
number
OPPT
 
2002
 
0026,
must
be
received
on
or
before
August
29,
2002.
ADDRESSES:
Comments
may
be
submitted
by
mail,
electronically,
or
in
person.
Please
follow
the
detailed
instructions
for
each
method
as
provided
in
Unit
I.
of
the
SUPPLEMENTARY
INFORMATION.
To
ensure
proper
receipt
by
EPA,
it
is
imperative
that
you
identify
docket
control
number
OPPT
 
2002
 
0026
in
the
subject
line
on
the
first
page
of
your
response.

FOR
FURTHER
INFORMATION
CONTACT:
For
general
information
contact:
Barbara
Cunningham,
Acting
Director,
Environmental
Assistance
Division
(
7408M),
Office
of
Pollution
Prevention
and
Toxics,
Environmental
Protection
Agency,
1200
Pennsylvania
Ave.,
NW.,
Washington,
DC
20460;
telephone
numbers:
(
202)
554
 
1404;
e­
mail
address:
TSCA­
Hotline@
epa.
gov.
For
technical
information
contact:
John
D.
Walker,
ITC
Executive
Director
(
7401M),
Environmental
Protection
Agency,
1200
Pennsylvania
Ave.,
NW.,
Washington,
DC
20460;
telephone
number:
(
202)
564
 
7526;
fax:
(
202)
564
 
7528;
e­
mail
address:
walker.
johnd@
epa.
gov.

SUPPLEMENTARY
INFORMATION:

I.
General
Information
A.
Does
this
Action
Apply
to
Me?
This
notice
is
directed
to
the
public
in
general.
It
may,
however,
be
of
particular
interest
to
you
if
you
manufacture
(
defined
by
statute
to
include
import)
and/
or
process
TSCAcovered
chemicals
and
you
may
be
identified
by
the
North
American
Industrial
Classification
System
(
NAICS)
codes
325
and
32411.
Because
this
notice
is
directed
to
the
general
public
and
other
entities
may
also
be
interested,
the
Agency
has
not
attempted
to
describe
all
the
specific
entities
that
may
be
interested
in
this
action.
If
you
have
any
questions
regarding
the
applicability
of
this
action
to
a
particular
entity,
consult
the
technical
person
listed
under
FOR
FURTHER
INFORMATION
CONTACT.

B.
How
Can
I
Get
Additional
Information,
Including
Copies
of
this
Document
or
Other
Related
Documents?
1.
Electronically.
You
may
obtain
electronic
copies
of
this
document,
and
certain
other
related
documents
that
might
be
available
electronically,
from
the
EPA
Internet
Home
Page
at
http://
www.
epa.
gov/.
To
access
this
document,
on
the
Home
Page
select
``
Laws
and
Regulations,''
``
Regulations
and
Proposed
Rules,''
and
then
look
up
the
entry
for
this
document
under
the
``
Federal
Register
 
Environmental
Documents.''
You
can
also
go
directly
to
the
Federal
Register
listings
at
http://
www.
epa.
gov/
fedrgstr/.
You
may
also
access
additional
information
about
the
ITC
and
the
TSCA
testing
program
through
the
web
site
for
the
Office
of
Prevention,
Pesticides
and
Toxic
Substances
(
OPPTS)
at
http://
www.
epa.
gov/
opptsfrs/
home/
opptsim.
htm/,
or
go
directly
to
the
ITC
home
page
at
http://
www.
epa.
gov/
opptintr/
itc/.
2.
In
person.
The
Agency
has
established
an
official
record
for
this
action
under
docket
control
number
OPPT
 
2002
 
0026.
The
official
record
consists
of
the
documents
specifically
referenced
in
this
action,
any
public
comments
received
during
an
applicable
comment
period,
and
other
information
related
to
this
action,
including
any
information
claimed
as
Confidential
Business
Information
(
CBI).
This
official
record
includes
the
documents
that
are
physically
located
in
the
docket,
as
well
as
the
documents
that
are
referenced
in
those
documents.
The
public
version
of
the
official
record
does
not
include
any
information
claimed
as
CBI.
The
public
version
of
the
official
record,
which
includes
printed,
paper
versions
of
any
electronic
comments
submitted
during
an
applicable
comment
period,
is
available
for
inspection
in
the
TSCA
Nonconfidential
Information
Center,
North
East
Mall
Rm.
B
 
607,
Waterside
Mall,
401
M
St.,
SW.,
Washington,
DC.
The
Center
is
open
from
noon
to
4
p.
m.,
Monday
through
Friday,
excluding
legal
holidays.
The
telephone
number
for
the
Center
is
(
202)
260
 
7099.

C.
How
and
to
Whom
Do
I
Submit
Comments?
You
may
submit
comments
through
the
mail,
in
person,
or
electronically.
To
ensure
proper
receipt
by
EPA,
it
is
imperative
that
you
identify
docket
control
number
OPPT
 
2002
 
0026
in
the
subject
line
on
the
first
page
of
your
response.
1.
By
mail.
Submit
your
comments
to:
Document
Control
Office
(
7407M),
Office
of
Pollution
Prevention
and
Toxics
(
OPPT),
Environmental
Protection
Agency,
1200
Pennsylvania
Ave.,
NW.,
Washington,
DC
20460.
2.
In
person
or
by
courier.
Deliver
your
comments
to:
OPPT
Document
Control
Office
(
DCO)
in
EPA
East
Building
Rm.
6428,
1201
Constitution
Ave.,
NW.,
Washington,
DC.
The
DCO
is
open
from
8
a.
m.
to
4
p.
m.,
Monday
through
Friday,
excluding
legal
holidays.
The
telephone
number
for
the
DCO
is
(
202)
564
 
8930.
3.
Electronically.
You
may
submit
your
comments
electronically
by
e­
mail
to:
oppt.
ncic@
epa.
gov,
or
mail
your
computer
disk
to
the
address
identified
above.
Do
not
submit
any
information
electronically
that
you
consider
to
be
CBI.
Electronic
comments
must
be
submitted
as
an
ASCII
file
avoiding
the
use
of
special
characters
and
any
form
of
encryption.
Comments
and
data
will
also
be
accepted
on
standard
disks
in
WordPerfect
6.1/
8.0
or
ASCII
file
format.
All
comments
in
electronic
form
must
be
identified
by
docket
control
number
OPPT
 
2002
 
0026.
Electronic
comments
may
also
be
filed
online
at
many
Federal
Depository
Libraries.

D.
How
Should
I
Handle
CBI
Information
that
I
Want
to
Submit
to
the
Agency?
Do
not
submit
any
information
electronically
that
you
consider
to
be
CBI.
You
may
claim
information
that
you
submit
to
EPA
in
response
to
this
document
as
CBI
by
marking
any
part
or
all
of
that
information
as
CBI.
Information
so
marked
will
not
be
disclosed
except
in
accordance
with
procedures
set
forth
in
40
CFR
part
2.

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Federal
Register
/
Vol.
67,
No.
146
/
Tuesday,
July
30,
2002
/
Notices
In
addition
to
one
complete
version
of
the
comment
that
includes
any
information
claimed
as
CBI,
a
copy
of
the
comment
that
does
not
contain
the
information
claimed
as
CBI
must
be
submitted
for
inclusion
in
the
public
version
of
the
official
record.
Information
not
marked
confidential
will
be
included
in
the
public
version
of
the
official
record
without
prior
notice.
If
you
have
any
questions
about
CBI
or
the
procedures
for
claiming
CBI,
please
consult
the
technical
person
listed
under
FOR
FURTHER
INFORMATION
CONTACT.

E.
What
Should
I
Consider
as
I
Prepare
My
Comments
for
EPA?

We
invite
you
to
provide
your
views
and
comments
on
the
50th
ITC
Report.
You
may
find
the
following
suggestions
helpful
for
preparing
your
comments:
1.
Explain
your
views
as
clearly
as
possible.
2.
Describe
any
assumptions
that
you
used.
3.
Provide
copies
of
any
technical
information
and/
or
data
you
used
that
support
your
views.
4.
Provide
specific
examples
to
illustrate
your
concerns.
5.
Offer
alternatives
for
improvement.
6.
To
ensure
proper
receipt
by
EPA,
be
sure
to
identify
the
docket
control
number
assigned
to
this
action
in
the
subject
line
on
the
first
page
of
your
response.
You
may
also
provide
the
name,
date,
and
Federal
Register
citation.

II.
Background
The
Toxic
Substances
Control
Act
(
TSCA)
(
15
U.
S.
C.
2601
et
seq.)
authorizes
the
Administrator
of
the
EPA
to
promulgate
regulations
under
TSCA
section
4(
a)
requiring
testing
of
chemicals
and
chemical
groups
in
order
to
develop
data
relevant
to
determining
the
risks
that
such
chemicals
and
chemical
groups
may
present
to
health
or
the
environment.
Section
4(
e)
of
TSCA
established
the
ITC
to
recommend
chemicals
and
chemical
groups
to
the
Administrator
of
the
EPA
for
priority
testing
consideration.
Section
4(
e)
of
TSCA
directs
the
ITC
to
revise
the
TSCA
section
4(
e)
Priority
Testing
List
at
least
every
6
months.

A.
The
50th
ITC
Report
The
50th
ITC
Report
was
transmitted
to
EPA's
Administrator
on
May
28,
2002,
and
is
included
in
this
notice.
In
the
50th
ITC
Report,
the
ITC:
1.
Rescinds
its
request
in
the
48th
ITC
Report
to
EPA
for
the
addition
to
the
PAIR
rule
of
12
of
the
15
DEBITS
chemicals.
The
12
DEBITS
chemicals
are
3
``
chloroalkenes,''
5
``
chlorinated
trihalomethyl
pyridines,''
1
``
trihaloethylidene
bisbenzene''
(
benzene,
1,1'­(
2,2,2­
trichloroethylidene)
bis­,
CAS
No.
2971
 
22
 
4);
and
3
``
trichlorophenyldihydropyrazols''
(
benzamide,
3­
amino­
N­[
4,5­
dihydro­
5­
oxo­
1­(
2,4,6­
trichlorophenyl)­
1Hpyrazol
3­
yl]­,
CAS
No.
40567
 
18
 
8);
3H­
pyrazol­
3­
one,
5­((
5­
amino­
2­
chlorophenyl)
amino)­
2,4­
dihydro­
2­
(
2,4,6­
trichlorophenyl)­,
CAS
No.
53411
 
33
 
9;
and
benzamide,
N­(
4,5­
dihydro­
5­
oxo­
1­(
2,4,6­
trichlorophenyl)­
1H­
pyrazol­
3­
yl)­
3­
nitro­,
CAS
No.
63134
 
25
 
8.
The
ITC
is
not
rescinding
its
request
in
the
48th
ITC
Report
to
add
benzenamine,
3­
chloro­
2,6­
dinitro­
N,
Ndipropyl
4­(
trifluoromethyl)­,
CAS
No.
29091
 
20
 
1;
3H­
pyrazol­
3­
one,
5­((
2­
chloro­
5­
nitrophenyl)
amino)­
2,4­
dihydro­
2­(
2,4,6­
trichlorophenyl)­,
CAS
No.
30707
 
68
 
7;
and
phenol,
4,4'­[
2,2,2­
trifluoro­
1­
(
trifluoromethyl)
ethylidene]
bis­,
CAS
No.
1478
 
61
 
1
to
the
PAIR
rule.
2.
Adds
3
chemicals
to
the
PAIR
rule:
1
DEBITS
chemical
(
stannane,
dimethylbis[(
1­
oxoneodecyl)
oxy]­,
CAS
No.
68928
 
76
 
7)
from
the
49th
Report;
1
DEBITS
chemical
(
benzene,
1,3,5­
tribromo­
2­(
2­
propenyloxy)­,
CAS
No.
3278
 
89
 
5)
and
1­
triazene,
1,3­
diphenyl­,
CAS
No.
136
 
35
 
6
from
the
50th
ITC
Report.
3.
Adds
stannane,
dimethylbis[(
1­
oxoneodecyl)
oxy]­,
CAS
No.
68928
 
76
 
7;
benzene,
1,3,5­
tribromo­
2­(
2­
propenyloxy)­,
CAS
No.
3278
 
89
 
5;
and
1­
triazene,
1,3­
diphenyl­,
CAS
No.
136
 
35
 
6
to
the
TSCA
section
8(
d)
HaSDR
rule.
4.
Solicits
comments
on
its
VISION
and
VISP.

B.
Status
of
the
Priority
Testing
List
The
ITC
is
adding
benzene,
1,3,5­
tribromo­
2­(
2­
propenyloxy)­
(
CAS
No.
3278
 
89
 
5)
and
1­
triazene,
1,3­
diphenyl­
(
CAS
No.
136
 
35
 
6)
to
the
Priority
Testing
List.
The
ITC
is
removing
acetone,
9
``
alkylphenols''
and
``
alkylphenol
ethoxylates''
added
in
the
37th
ITC
Report,
7
``
nonylphenol
ethoxylates''
added
in
the
39th
ITC
Report,
4
``
alkylphenols''
and
``
alkylphenol
ethoxylates''
added
in
the
41st
ITC
Report,
3
DEBITS
chemicals
added
in
the
46th
ITC
Report,
3
DEBITS
chemicals
(
3
``
chloroalkenes'')
added
in
the
47th
ITC
Report,
and
9
DEBITS
chemicals
added
in
the
48th
ITC
Report
from
the
Priority
Testing
List.
The
current
TSCA
4(
e)
Priority
Testing
List
as
of
May
2002
can
be
found
in
Table
1
of
the
50th
ITC
Report
which
is
included
in
this
notice.
List
of
Subjects
Environmental
protection,
Chemicals,
Hazardous
substances.

Dated:
July
22,
2002.
Charles
M.
Auer,
Director,
Chemical
Control
Division,
Office
of
Pollution
Prevention
and
Toxics.

Fiftieth
Report
of
the
TSCA
Interagency
Testing
Committee
to
the
Administrator,
U.
S.
Environmental
Protection
Agency
Table
of
Contents
Summary
I.
Background
II.
TSCA
Section
8
Reporting
A.
TSCA
Section
8
Reporting
Rules
B.
ITC's
Use
of
TSCA
Section
8
and
Other
Information
C.
Promoting
More
Efficient
Use
of
Information
Submission
Resources
D.
Coordinating
Information
Requests
E.
Requests
to
Promulgate
TSCA
Section
8(
a)
PAIR
and
Section
8(
d)
HaSDR
Rules
III.
ITC's
Activities
During
this
Reporting
Period
(
November
2001
to
April
2002)
A.
VISION
B.
DEBITS
IV.
Revisions
to
the
TSCA
Section
4(
e)
Priority
Testing
List
A.
Chemicals
Added
to
the
Priority
Testing
List
1.
Benzene,
1,3,5­
tribromo­
2­(
2­
propenyloxy)­.
2.
1­
Triazene,
1,3­
diphenyl.
B.
Chemicals
Removed
From
the
Priority
Testing
List
1.
Acetone.
2.
Twenty
alkylphenols
and
alkylphenol
ethoxylates.
3.
Three
DEBITS
chemicals
from
the
46th
ITC
Report.
4.
Three
DEBITS
chemicals
from
the
47th
ITC
Report.
5.
Nine
DEBITS
chemicals
from
the
48th
ITC
Report.
V.
References
VI.
The
TSCA
Interagency
Testing
Committee
SUMMARY
In
this
50th
ITC
Report,
the
ITC
is
rescinding
its
request
to
the
EPA
to
add
12
Degradation
Effects
Bioconcentration
Information
Testing
Strategies
(
DEBITS)
chemicals
to
the
TSCA
section
8(
a)
Preliminary
Assessment
Information
Reporting
(
PAIR)
rule
(
3
DEBITS
chemicals
from
the
47th
ITC
Report
and
9
DEBITS
chemicals
from
the
48th
ITC
Report).
However,
the
ITC
is
asking
the
EPA
to
add
6
chemicals
to
the
PAIR
rule,
3
DEBITS
chemicals
(
3­
chloro­
2,6­
dinitro­
N,
Ndipropyl
4­(
trifluoromethyl)­
benzeneamine,
3H­
pyrazol­
3­
one;
5­((
2­
chloro­
5­
nitrophenyl)
amino)­
2,4­
dihydro­
2­(
2,4,6­
trichlorophenyl)­;
and
phenol,
4,4'­[
2,2,2­
trifluoro­
1­(
trifluoromethyl)
ethylidene]
bis­),
from
the
48th
ITC
Report,
1
DEBITS
chemical
(
stannane,
dimethylbis[(
1­
oxoneodecyl)
oxy]­
),
from
the
49th
ITC
Report,
1
DEBITS
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2002
/
Notices
chemical
(
benzene,
1,3,5­
tribromo­
2­(
2­
propenyloxy)­),
and
from
the
50th
ITC
Report,
1­
triazene,
1,3­
diphenyl.
The
ITC
is
also
asking
the
EPA
to
add
stannane,
dimethylbis[(
1­
oxoneodecyl)
oxy]­;
benzene,
1,3,5­
tribromo­
2­(
2­
propenyloxy)­;
and
1­
triazene,
1,3­
diphenyl
to
the
TSCA
section
8(
d)
Health
and
Safety
Data
Reporting
(
HaSDR)
rule.
The
ITC
is
adding
benzene,
1,3,5­
tribromo­
2­(
2­
propenyloxy)­
and
1­
triazene,
1,3­
diphenyl
to
the
Priority
Testing
List.
The
ITC
is
removing
acetone,
9
alkylphenols
and
alkylphenol
ethoxylates
from
the
37th
ITC
Report,
7
nonylphenol
ethoxylates
from
the
39th
ITC
Report,
4
alkylphenols
and
alkylphenol
ethoxylates
from
the
41st
ITC
Report,
3
DEBITS
chemicals
from
the
46th
ITC
Report,
3
DEBITS
chemicals
from
the
47th
ITC
Report,
and
9
DEBITS
chemicals
from
the
48th
ITC
Report
and
from
the
Priority
Testing
List.
The
ITC
is
soliciting
comments
on
its
Voluntary
Information
Submissions
Innovative
Online
Network
(
VISION)
and
Voluntary
Information
Submissions
Policy
(
VISP).
The
revised
TSCA
section
4(
e)
Priority
Testing
List
follows
as
Table
1
of
this
appendix.

TABLE
1.
 
THE
TSCA
SECTION
4(
E)
PRIORITY
TESTING
LIST
(
MAY
2002)

Report
Date
Chemical
name/
Group
Action
28
May
1991
Chemicals
with
Low
Confidence
Reference
Dose
(
RfD)
Thiophenol
Designated
31
January
1993
13
Chemicals
with
insufficient
dermal
absorption
rate
data
Designated
32
May
1993
16
Chemicals
with
insufficient
dermal
absorption
rate
data
Designated
35
November
1994
4
Chemicals
with
insufficient
dermal
absorption
rate
data
Designated
37
November
1995
6
Alkylphenols
and
alkylphenol
ethoxylates
Recommended
39
November
1996
1
Nonylphenol
ethoxylate
Recommended
41
November
1997
3
Alkylphenols
and
alkylphenol
ethoxylates
Recommended
42
May
1998
3­
Amino­
5­
mercapto­
1,2,4­
triazole
Recommended
42
May
1998
Glycoluril
Recommended
46
May
2000
8
Nonylphenol
polyethoxylate
degradation
products
Recommended
47
November
2000
37
Indium
compounds
Recommended
47
November
2000
Pentachlorothiophenol
Recommended
48
May
2001
Phenol,
4,4'­[
2,2,2­
trifluoro­
1­(
trifluoromethyl)
ethylidene]
bis­
Recommended
48
May
2001
3­
Chloro­
2,6­
dinitro­
N,
N­
dipropyl­
4­(
trifluoromethyl)­
benzeneamine
Recommended
48
May
2001
3H­
Pyrazol­
3­
one,
5­[(
2­
chloro­
5­
nitrophenyl)
amino]­
2,4­
dihydro­
2­
(
2,4,6­
trichlorophenyl)
Recommended
49
November
2001
Stannane,
dimethylbis[(
1­
oxoneodecyl)
oxy]­
Recommended
50
May
2002
Benzene,
1,3,5­
tribromo­
2­(
2­
propenyloxy)­
Recommended
50
May
2002
1­
Triazene,
1,3­
diphenyl
Recommended
I.
Background
The
ITC
was
established
by
section
4(
e)
of
TSCA
``
to
make
recommendations
to
the
Administrator
respecting
the
chemical
substances
and
mixtures
to
which
the
Administrator
should
give
priority
consideration
for
the
promulgation
of
a
rule
for
testing
under
section
4(
a)....
At
least
every
six
months
...,
the
Committee
shall
make
such
revisions
to
the
Priority
Testing
List
as
it
determines
to
be
necessary
and
transmit
them
to
the
Administrator
together
with
the
Committee's
reasons
for
the
revisions''
(
Public
Law
94
 
469,
90
Stat.
2003
et
seq.,
15
U.
S.
C.
2601
et
seq.).
Since
its
creation
in
1976,
the
ITC
has
submitted
49
semi­
annual
(
May
and
November)
reports
to
the
EPA
Administrator
transmitting
the
Priority
Testing
List
and
its
revisions.
ITC
Reports
are
available
from
the
ITC's
web
site
(
http://
www.
epa.
gov/
opptintr/
itc)
within
a
few
days
of
submission
to
the
Administrator
and
from
http://
www.
epa.
gov/
fedrgstr
after
publication
in
the
Federal
Register.
The
ITC
meets
monthly
and
produces
its
revisions
to
the
Priority
Testing
List
with
administrative
and
technical
support
from
the
ITC
staff,
ITC
members
and
their
U.
S.
Government
organizations,
and
contract
support
provided
by
EPA.
ITC
members
and
staff
are
listed
at
the
end
of
this
Report.
The
50th
ITC
Report
marks
a
significant
milestone
for
the
ITC.
Since
its
first
meeting
on
February
5,
1977,
the
ITC
has
convened
425
meetings,
screened
thousands
of
chemicals,
and
reviewed
more
than
2,500
organic,
organo­
metallic,
and
inorganic
chemicals
to
identify
those
with
suspicions
of
toxicity,
environmental
release,
and
consumer
or
occupational
exposures,
but
few,
if
any
data
(
Ref.
14).
In
its
50
Reports,
the
ITC
has
added
to
the
Priority
Testing
List
and
recommended
testing
or
information
reporting
for
81
individual
chemicals
and
80
chemical
groups
(
about
1,400
chemicals)
for
priority
consideration
by
the
EPA
Administrator.
In
response,
the
EPA
has
published
200
Federal
Register
notices
and
reviewed
hundreds
of
test
protocols
and
data
submissions
and
the
U.
S.
chemical
industry
has
developed
over
1,000
tests
and
submitted
more
than
75,000
unpublished
health
and
safety
studies
to
the
EPA.
As
of
1992,
testing
was
ongoing,
proposed,
under
consideration,
required
or
voluntarily
conducted
for
85%
of
the
chemicals
and
chemical
groups
recommended
by
the
ITC
(
Ref.
14).
Many
of
the
data
developed
as
a
result
of
ITC's
recommendations
have
been
incorporated
into
Material
Safety
Data
Sheets,
used
by
U.
S.
Government
and
industry
organizations
to
develop
hazard
assessments
and
included
in
the
Organization
for
Economic
Cooperation
and
Development
(
OECD)
Screening
Information
Data
Set
(
SIDS)
dossiers
(
e.
g.,
100%
of
the
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30,
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/
Notices
chemicals
in
phase
I
of
the
OECD
SIDS
program
were
reviewed
by
the
ITC
prior
to
preparation
of
SIDS
dossiers),
(
Ref.
14).
Wellknown
examples
of
chemicals
for
which
data
have
been
developed
as
a
result
of
ITC
recommendations
include
alkyl
phthalates,
chlorinated
paraffins
and
hexachlorobutadiene
(
Ref.
1),
acrylamide,
aryl
phosphates,
methylene
chloride
and
trichloroethane
(
Ref.
2),
chlorinated
benzenes
(
Refs.
1
and
3),
benzidine­,
o­
dianisidine­
and
o­
toluidine­
based
dyes
(
Ref.
4),
phenylenediamines
(
Ref.
5),
alkyl
tins
and
fluoroalkenes
(
Ref.
6),
octylphenol
(
Ref.
7),
bisphenol
A
(
Ref.
8),
tetrabromobisphenol
A
(
Ref.
9),
methyl
tertiary
butyl
ether
or
MTBE
(
Ref.
10),
and
brominated
flame
retardants,
including
brominated
diphenyl
ethers
(
Ref.
11).

II.
TSCA
Section
8
Reporting
A.
TSCA
Section
8
Reporting
Rules
Following
receipt
of
the
ITC's
Report
(
and
the
revised
Priority
Testing
List)
by
the
EPA
Administrator,
the
EPA's
Office
of
Pollution
Prevention
and
Toxics
(
OPPT)
promulgates
TSCA
section
8(
a)
PAIR
and
TSCA
section
8(
d)
HaSDR
rules
for
chemicals
added
to
the
Priority
Testing
List.
The
PAIR
rule
requires
producers
and
importers
of
Chemical
Abstract
Service
(
CAS)­
numbered
chemicals
added
to
the
Priority
Testing
List
to
submit
production
and
exposure
reports
under
TSCA
section
8(
a).
The
HaSDR
rule
requires
producers,
importers,
and
processors
of
all
chemicals
(
including
those
with
no
CAS
numbers)
added
to
the
Priority
Testing
List
to
submit
unpublished
health
and
safety
studies
under
TSCA
section
8(
d)
that
must
be
in
compliance
with
the
revised
HaSDR
rule
(
63
FR
15765,
April
1,
1998)
(
FRL
 
5750
 
4)
codified
at
40
CFR
part
716.
All
submissions
must
be
received
by
the
EPA
within
90
days
of
the
reporting
rules
Federal
Register
publication
date.
The
reporting
rules
are
automatically
promulgated
by
OPPT
unless
otherwise
requested
by
the
ITC.
Under
the
ITC's
VISION
and
VISP,
promulgation
of
HaSDR
rules
for
most
chemicals
that
are
added
to
the
Priority
Testing
List
has
been
delayed
to
allow
voluntary
submission
of
studies
of
specific
interest
(
see
section
II.
C.
for
further
details
on
VISION
and
VISP).

B.
ITC's
Use
of
TSCA
Section
8
and
Other
Information
The
ITC
reviews
the
TSCA
section
8(
a)
PAIR
rule
reports,
TSCA
section
8(
d)
HaSDR
rule
studies
and
other
information
that
becomes
available
after
the
ITC
adds
chemicals
to
the
Priority
Testing
List.
Other
information
includes
TSCA
section
4(
a)
and
4(
d)
studies;
TSCA
section
8(
c)
submissions;
TSCA
section
8(
e)
``
substantial
risk''
notices;
``
For
Your
Information''
(
FYI)
submissions;
ITC
voluntary
submissions,
unpublished
data
submitted
to
and
from
U.
S.
Government
organizations
represented
on
the
ITC;
published
papers,
as
well
as
use,
exposure,
effects,
and
persistence
data
that
are
voluntarily
submitted
to
the
ITC
by
manufacturers,
importers,
processors,
and
users
of
chemicals
recommended
by
the
ITC.
The
ITC
reviews
this
information
and
determines
if
data
needs
should
be
revised,
if
chemicals
should
be
removed
from
the
Priority
Testing
List,
or
if
recommendations
should
be
changed
to
designations.

C.
Promoting
More
Efficient
Use
of
Information
Submission
Resources
To
promote
more
efficient
use
of
information
submission
resources,
the
ITC
developed
the
VISP
and
VISION.
The
VISP
provides
examples
of
data
needed
by
ITC
member
U.
S.
Government
organizations,
examples
of
studies
that
should
not
be
submitted,
the
milestones
for
submitting
information,
guidelines
for
using
the
TSCA
Electronic
HaSDR
Form
and
instructions
for
electronically
submitting
full
studies.
The
VISP
is
described
in
the
ITC's
41st
Report
(
63
FR
17658,
April
9,
1998)
(
FRL
 
5773
 
5)
and
is
accessible
through
the
world
wide
web
(
http://
www.
epa.
gov/
opptintr/
itc/
visp.
htm
).
To
facilitate
the
implementation
of
the
VISP,
the
ITC
developed
the
VISION.
The
VISION
is
described
in
the
ITC's
42nd
ITC
Report
(
63
FR
42554,
August
7,
1998)
(
FRL
 
5797
 
8)
and
is
also
accessible
through
the
world
wide
web
(
http://
www.
epa.
gov/
opptintr/
itc/
vision.
htm).
The
VISION
includes
links
to
the
TSCA
Electronic
HaSDR
Form
(
http://
www.
epa.
gov/
opptintr/.
er/
hasd.
htm)
including
revised
section
3.2
of
the
TSCA
Electronic
HaSDR
Form
to
provide
more
use
and
exposure
information
(
for
details
see
the
46th
ITC
Report;
65
FR
75552,
December
1,
2000)
(
FRL
 
6594
 
7).
The
ITC
requests
that
chemical
producers,
importers,
processors,
and
users
provide
information
electronically
via
VISION
on
chemicals
for
which
the
ITC
is
soliciting
voluntary
information.
If
the
ITC
does
not
receive
voluntary
information
submissions
to
meet
its
data
needs
according
to
the
procedures
in
VISP,
the
ITC
may
then
ask
the
EPA
to
add
those
chemicals
to
a
TSCA
section
8(
d)
HaSDR
rule
to
determine
if
there
are
unpublished
data
to
meet
those
needs
(
see
section
III.
A.
that
requests
comments
on
the
need
to
continue
VISION
and
VISP).

D.
Coordinating
Information
Rrequests
To
avoid
duplicate
reporting,
the
ITC
carefully
coordinates
its
information
solicitations
and
reporting
requirements
with
other
national
and
international
testing
programs,
(
e.
g.,
the
National
Toxicology
Program,
the
OECD
SIDS
program
and
the
EPA's
High
Production
Volume
(
HPV)
Challenge
program).
The
ITC
is
currently
focusing
its
efforts
on
persistent
non­
HPV
chemicals
that
have
bioconcentration
and
exposure
potential,
but
few,
if
any,
publicly
available
ecological
or
health
effects
data.
The
ITC
is
working
with
the
EPA
Persistent
Bioaccumulative
Toxics
(
PBT),
Endocrine
Disruption,
and
perfluoroctylsulfonate
chemicals
workgroups
to
identify
potentially
toxic
chemicals
with
few
data
to
complement
the
objectives
of
those
programs.

E.
Requests
to
Promulgate
TSCA
Section
8(
a)
PAIR
and
Section
8(
d)
HaSDR
Rules
The
ITC
asked
the
EPA
to
add
3
chloroalkenes
to
the
TSCA
section
8(
a)
PAIR
rule
in
its
48th
ITC
Report
(
66
FR
51276,
October
5,
2001)
(
FRL
 
6786
 
7).
In
addition,
the
ITC
asked
the
EPA
to
add
5
chlorinated
trihalomethyl
pyridines,
2
trihaloethylidene
bisbenzenes,
4
trichlorophenyldihydropyrazols,
and
3­
chloro­
2,6­
dinitro­
N,
N­
dipropyl­
4­
(
trifluoromethyl)­
benzeneamine
to
the
TSCA
section
8(
a)
PAIR
rule
in
its
48th
ITC
Report
(
66
FR
51276,
October
5,
2001).
At
this
time,
the
ITC
is
rescinding
its
request
to
add
the
3
chloroalkenes;
5
chlorinated
trihalomethyl
pyridines;
1
of
the
trihaloethylidene
bisbenzenes
(
benzene,
1,1'­
(
2,2,2­
trichloroethylidene)
bis­,
CAS
No.
2971
 
22
 
4);
and
3
of
the
trichlorophenyldihydropyrazols
(
benzamide,
3­
amino­
N­[
4,5­
dihydro­
5­
oxo­
1­
(
2,4,6­
trichlorophenyl)­
1H­
pyrazol­
3­
yl,
CAS
No.
40567
 
18
 
8,
3H­
pyrazol­
3­
one,
5­((
5­
amino­
2­
chlorophenyl)
amino)­
2,4­
dihydro­
2­(
2,4,6­
trichlorophenyl)­,
CAS
No.
53411
 
33
 
9,
and
benzamide,
N­(
4,5­
dihydro­
5­
oxo­
1­(
2,4,6­
trichlorophenyl)­
1H­
pyrazol­
3­
yl)­
3­
nitro­,
CAS
No.
63134
 
25
 
8)
to
the
TSCA
section
8(
a)
PAIR
rule,
either
because
no
production
or
importation
data
were
submitted
to
the
EPA
in
response
to
the
1998
Inventory
Update
Rule
(
IUR)
or
because
the
predicted
bioconcentration
factors
(
BCFs)
were
judged
to
be
too
low
to
warrant
priority
consideration
at
this
time.
The
ITC
is
not
rescinding
its
request
to
add
3­
chloro­
2,6­
dinitro­
N,
N­
dipropyl­
4­
(
trifluoromethyl)­
benzeneamine
(
CAS
No.
29091
 
20
 
1),
3H­
pyrazol­
3­
one,
5­((
2­
chloro­
5­
nitrophenyl)
amino)­
2,4­
dihydro­
2­(
2,4,6­
trichlorophenyl)­
(
CAS
No.
30707
 
68
 
7),
and
phenol,
4,4'­[
2,2,2­
trifluoro­
1­
(
trifluoromethyl)
ethylidene]
bis­
(
CAS
No.
1478
 
61
 
1)
to
the
TSCA
section
8(
a)
PAIR
rule.
At
this
time,
the
ITC
is
also
asking
the
EPA
to
add
stannane,
dimethylbis[(
1­
oxoneodecyl)
oxy]­
(
CAS
No.
68928
 
76
 
7),
benzene,
1,3,5­
tribromo­
2­(
2­
propenyloxy)­
(
CAS
No.
3278
 
89
 
5)
and
1­
triazene,
1,3­
diphenyl
(
CAS
No.
136
 
35
 
6)
to
the
TSCA
section
8(
a)
PAIR
rule.
Stannane,
dimethylbis[(
1­
oxoneodecyl)
oxy]­
and
benzene,
1,3,5­
tribromo­
2­(
2­
propenyloxy)­
are
being
added
to
the
TSCA
section
8(
a)
PAIR
rule,
because
they
are
estimated
to
persist
and
have
predicted
BCFs
of
8,650
and
4,019,
respectively,
few
toxicity
data
and
a
need
for
additional
use
and
exposure
data,
beyond
that
provided
by
the
manufacturers.
1­
Triazene,
1,3­
diphenyl
is
being
added
to
the
TSCA
section
8(
a)
PAIR
rule,
because
it
is
a
predicted
carcinogen
based
on
its
metabolism
and
because
the
ITC
needs
occupational
exposure
data.
At
this
time,
the
ITC
is
also
asking
the
EPA
to
add
stannane,
dimethylbis[(
1­
oxoneodecyl)
oxy]­,
benzene,
1,3,5­
tribromo­
2­(
2­
propenyloxy)­
and
1­
triazene,
1,3­
diphenyl
to
the
TSCA
section
8(
d)
HaSDR
rule.
Stannane,
dimethylbis[(
1­
oxoneodecyl)
oxy]­
is
being
added
to
the
TSCA
section
8(
d)
HaSDR
rule,
because
the
ITC
needs
to
know
if
there
are
other
toxicity
data
in
addition
to
that
described
in
section
IV.
A.
2.
and
3.
of
the
49th
Report
(
67
FR
10298,
March
6,
2002)
(
FRL
 
6820
 
8).
The
ITC
needs
ecological
effects
and
more
health
effects
data;
only
studies
where
stannane,
dimethylbis[(
1­
oxoneodecyl)
oxy]­
is
 
90%
of
the
test
substance
by
weight
should
be
submitted.
Benzene,
1,3,5­
tribromo­
2­(
2­
propenyloxy)­
is
being
added
to
the
TSCA
section
8(
d)
HaSDR
rule,
because
the
ITC
needs
to
know
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/
Notices
if
there
are
other
toxicity
data
in
addition
to
that
described
in
section
IV.
A.
1.
iii.
of
this
Report.
The
ITC
needs
ecological
effects
and
more
health
effects
data;
only
studies
where
benzene,
1,3,5­
tribromo­
2­(
2­
propenyloxy)­
is
 
90%
of
the
test
substance
by
weight
should
be
submitted.
1­
Triazene,
1,3­
diphenyl
is
being
added
to
the
TSCA
section
8(
d)
HaSDR
rule,
because
the
ITC
needs
pharmacokinetics,
genotoxicity,
subchronic
and
chronic
toxicity,
reproductive,
and
developmental
toxicity
data.
Only
studies
where
diazoaminobenzene
is
 
90%
of
the
test
substance
by
weight
should
be
submitted.

III.
ITC's
Activities
During
this
Reporting
Period
(
November
2001
to
April
2002)

A.
VISION
The
ITC
is
the
only
organization
for
which
the
EPA
can
promulgate
direct
TSCA
section
8(
d)
HaSDR
final
rules.
As
such,
when
the
EPA
convened
public
meetings
to
discuss
revisions
to
the
TSCA
section
8(
d)
HaSDR
rule
(
63
FR
15765,
April
1,
1998)
(
FRL
 
5750
 
4),
the
ITC
was
invited
to
provide
and
respond
to
comments
on
this
rule.
One
of
the
most
consistent
comments
by
the
chemical
industry
was
that
the
ITC
should
offer
more
opportunities
to
provide
voluntary
information
submissions
(
to
avoid
the
mandatory
requirements
of
submitting
information
in
response
to
a
TSCA
section
8(
d)
HaSDR
rule).
In
response
to
these
chemical
industry
requests,
the
ITC
developed
VISP,
VISION,
and
the
TSCA
Electronic
HaSDR
Form,
and
is
currently
evaluating
their
effectiveness.
The
ITC
developed
VISP,
VISION,
and
the
TSCA
Electronic
HaSDR
Form
as
tools
to
provide
a
more
cost­
effective
method
for
chemical
producers,
importers,
processors,
and
users
of
ITC­
recommended
chemicals
to
provide
voluntary
information.
With
the
exception
of
3
trade
organizations,
the
Alkylphenols
&
Ethoxylates
Research
Council
(
APERC),
the
Color
Pigment
Manufacturers
Association
(
CPMA),
and
the
Ecological
and
Toxicological
Association
of
Organic
Dye
Manufacturers
(
ETAD),
and
4
manufacturers,
3M
Specialty
Materials,
Ciba
Speciality
Chemicals,
E.
I.
du
Pont
de
Nemours
and
Company,
and
Rohm
and
Haas
Company,
these
tools
have
not
been
used
by
chemical
producers,
importers,
processors,
and
users
of
ITC­
recommended
chemicals.
The
ITC
has
received
voluntary
information
submissions
on
<
15%
of
the
approximately
500
chemicals
for
which
the
ITC
has
solicited
voluntary
information
since
implementing
the
VISP
and
VISION,
in
effect
delaying
the
ITC's
ability
to
obtain
the
information
it
needs
to
make
decisions
and
meet
U.
S.
Government
data
needs.
The
ITC
recognizes
that
there
are
increasing
demands
on
the
chemical
industry
to
provide
information
in
response
to
voluntary
initiatives,
e.
g.,
the
OECD
SIDS
program,
EPA
HPV
Challenge
program
and
Voluntary
Children's
Chemical
Evaluation
Program
(
VCCEP).
The
ITC
supports
and
coordinates
its
voluntary
information
requests
with
these
programs.
However,
as
a
statutory­
mandated
organization
charged
with
screening
and
identifying
potentially
hazardous
chemicals,
the
ITC
also
recognizes
that
the
chemical
industry
has
the
responsibility
under
TSCA
and
under
the
principles
of
Responsible
Care
 
and
Chemical
Right­
to­
Know,
to
promptly
and
voluntarily
provide
information
on
the
ITC's
recommended
chemicals
to
be
used
in
subsequent
hazard,
exposure,
and
risk
assessments
by
the
U.
S.
Government
organizations
represented
on
the
ITC.
The
ITC
is
considering
whether
to
continue
the
use
of
the
VISP,
VISION,
and
the
TSCA
Electronic
HaSDR
Form
for
chemicals
added
to
the
Priority
Testing
List,
as
the
lack
of
use
of
these
tools
has
resulted
in
substantial
delays
in
obtaining
information
that
could
be
used
to
meet
the
ITC's
data
needs.
The
ITC
requests
comments
on
procedures
that
could
be
implemented
to
make
these
existing
tools
or
other
procedures
for
submitting
voluntary
information
more
effective.
Comments
in
a
word
processing
file
attached
to
an
e­
mail
to
walker.
johnd@
epa.
gov
are
preferred,
but
the
ITC
will
also
accept
comments
submitted
to
Dr.
John
D.
Walker
at
the
address
listed
at
the
end
of
this
Report
by
September
30,
2002.

B.
DEBITS
In
its
45th
through
49th
ITC
Reports,
the
ITC
described
its
strategies
to
screen
and
evaluate
chemicals
with
persistence
and
bioconcentration
potential.
These
activities
are
referred
to
as
DEBITS.
DEBITS
provides
a
means
to
prioritize
chemicals
for
information
reporting
and
testing
based
on
degradation
and
bioconcentration
potential
and
availability
of
effects
data.
Prior
to
this
reporting
period
the
ITC
made
information
reporting
or
testing
deferral
decisions
on
206
DEBITS
chemicals.
During
this
reporting
period,
the
ITC
completed
its
review
of
the
remaining
252
DEBITS
chemicals,
including
the
9
chemicals
discussed
in
this
section:
1.
Benzene,
1,3,5­
tribromo­
2­(
2­
propenyloxy)­
(
CAS
No.
3278
 
89
 
5),
2.
2,9­
Dimethylquinacridone
(
CAS
No.
980
 
26
 
7),
3.
1,2­
Ethanediyl
tetrakis
(
2­
chloro­
1­
methylethyl)
phosphate
(
CAS
No.
34621
 
99
 
3),
4.
Oxirane,
2,2',
2''­
(
methylidynetris(
phenyleneoxymethylene))
(
tris­
(
CAS
No.
66072
 
38
 
6),
5.
P­
cresol,
2,6­
di­
tert­
butyl­
alpha­
(
dimethylamino)
(
CAS
No.
88
 
27
 
7),
6.
Spiro
isobenzofuran­
1(
3H),
9'­
9H
xanthen­
3­
one,
3',
6'­
bis(
ethylamino)­
2',
7'­
dimethyl­
(
CAS
No.
41382
 
37
 
0),
7.
1H­
indole­
2­
carboxaldehyde,
2,3­
dihydro­
2­
hydroxy­
1,3,3­
trimethyl­(
4­
methoxyphenyl)
methylhydrazone
(
CAS
No.
81241
 
99
 
8),
8.
Phenoxazin­
5­
ium,
3,7­
bis(
diethylamino)­,
(
T­
4)­
tetrachlorozincate(
2­)
(
2:
1)
(
CAS
No.
63589
 
47
 
9),
and
9.
Oxirane,
2­[
2­(
4­
chlorophenyl)
ethyl]­
2­
(
1,1­
dimethylethyl)­
(
CAS
No.
80443
 
63
 
6).
The
ITC
is
adding
benzene,
1,3,5­
tribromo­
2­(
2­
propenyloxy)­
to
the
Priority
Testing
List
as
discussed
in
section
IV.
A.
1.
The
ITC
deferred
making
a
testing
recommendation
for
2,9­
dimethylquinacridone
because
its
absorption
potential
into
mammalian
tissues
is
expected
to
be
low
based
on
absorption
data
for
the
structurally
related
EPA
HPV
Challenge
chemical,
5,12­
dihydroquino(
2,3­
b)
acridine­
7,14­
dione
(
CAS
No.
1047
 
16
 
1).
1,2­
Ethanediyl
tetrakis
(
2­
chloro­
1­
methylethyl)
phosphate
was
previously
removed
from
the
Priority
Testing
List
in
the
ITC's
36th
ITC
Report
(
60
FR
42982,
August
17,
1995)
(
FRL
 
4965
 
6).
Oxirane,
2,2',
2''­(
methylidynetris
(
phenyleneoxymethylene))
tris­
was
deferred
for
testing
because
its
predicted
hydrolysis
half
life
was
3
days.
The
ITC
deferred
making
testing
recommendations
for
p­
cresol,
2,6­
ditert
butyl­
alpha­(
dimethylamino);
spiro
isobenzofuran­
1(
3H),
9'­
9H
xanthen­
3­
one,
3',
6'­
bis(
ethylamino)­
2',
7'­
dimethyl­;
1Hindole
2­
carboxaldehyde,
2,3­
dihydro­
2­
hydroxy­
1,3,3­
trimethyl­(
4­
methoxyphenyl)
methylhydrazone;
and
phenoxazin­
5­
ium,
3,7­
bis(
diethylamino)­,
(
T­
4)­
tetrachlorozincate(
2­)
(
2:
1)
because
of
their
low­
exposure
potential.
Oxirane,
2­[
2­(
4­
chlorophenyl)
ethyl]­
2­(
1,1­
dimethylethyl)­
was
deferred
for
testing
because
it
is
likely
to
be
tested
under
one
of
the
voluntary
HPV
chemical
testing
programs.
The
remaining
243
DEBITS
chemicals
deferred
for
testing
include
7
DEBITS
chemicals
with
predicted
BCFs
<
1,000
(
see
Table
2
of
this
appendix),
28
EPA
HPV
Challenge
program
DEBITS
chemicals
(
see
Table
3
of
this
appendix),
and
208
non­
HPV
DEBITS
chemicals
with
predicted
BCFs
of
3
 
13
(
see
Table
4
of
this
appendix).

TABLE
2.
 
SEVEN
DEBITS
CHEMICALS
WITH
PREDICTED
BCFS
<
1,000
CAS
No.
Chemical
name
Structural
class
BCF
827
 
94
 
1
2,6­
Dibromo­
4­
nitrobenzenamine
2,6­
Dibromoanilines
64
90
 
93
 
7
Bis[
4­(
Dimethylamino)
phenyl]
methanone
4,4'­
Substituted
benzophenones
467
6408
 
72
 
6
9,10­
Anthracenedione,
1,4­
diamino­
2,3­
diphenoxy­
Diaminoanthraquinones
585
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146
/
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July
30,
2002
/
Notices
TABLE
2.
 
SEVEN
DEBITS
CHEMICALS
WITH
PREDICTED
BCFS
<
1,000
 
Continued
CAS
No.
Chemical
name
Structural
class
BCF
19014
 
53
 
0
9,10­
Anthracenedione,
1­
amino­
2­(
4­((
hexahydro­
2­
oxo­
1H­
azepin­
1­
yl)
methyl)
phenoxy)­
4­
hydroxy­
Hydroxyamino
anthraquinones
336
596
 
03
 
2
Spiro
isobenzofuran­
1(
3H),
9'­
9Hxanthen­
3­
one,
4',
5'­
dibromo­
3;,
6'­
dihydroxy­,
disodium
salt
Spiro[
isobenzofuran­
1(
3H),
9'­[
9H]
xanthen]­
3­
ones
709
2280
 
49
 
1
N­
Phenyl­
N­(
trichloromethylsulfenyl)
benzene
sulfonamide
598
20941
 
65
 
5
Tetrakis(
diethylcarbamodithioato­
S,
S')
tellurium
478
TABLE
3.
 
TWENTY­
EIGHT
EPA
HPV
CHALLENGE
PROGRAM
DEBITS
CHEMICALS
CAS
No.
Chemical
name
Structural
Class
 
[
(
2­
Hydroxy­
1­
naphthalenyl)
azo]
benzenesulfonate
salts
7023
 
61
 
2
2­
Naphthalenecarboxylic
acid,
4­((
5­
chloro­
4­
methyl­
2­
sulfophenyl)
azo)­
3­
hydroxy­,
calcium
salt
(
1:
1)

7585
 
41
 
3
2­
Naphthalenecarboxylic
acid,
4­((
5­
chloro­
4­
methyl­
2­
sulfophenyl)
azo)­
3­
hydroxy­,
barium
salt
(
1:
1)

Structural
Class
 
[
[
4­[(
Phenyl)
azo]
phenyl]
azo]
benzenesulfonic
acid
salts
68555
 
86
 
2
Benzenesulfonic
acid,
4­((
5­
methoxy­
4­((
4­
methoxyphenyl)
azo)­
2­
methylphenyl)
azo)­,
sodium
salt
Structural
Class
 
4,4'­
bis(
Triazinylamino)
stilbene­
2,2'­
disulfonic
acid
salts
5182
 
81
 
9
2,2'­
Stilbenedisulfonic
acid,
4,4'­
bis((
4­
anilino­
6­
morpholino­
s­
triazin­
2­
yl)
amino)­,
disodium
salt
67786
 
25
 
8
Benzenesulfonic
acid,
2,2'­(
1,2­
ethenediyl)
bis(
5­((
4­(
bis(
2­
hydroxypropyl)
amino)­
6­((
4­
sulfophenyl)
amino)­
1,3,5­
triazin­
2­
yl)
amino)­,
tetrasodium
salt
Structural
Class
­
4­
Amino­
4'­
nitroazobenzenes
3618
 
72
 
2
Acetamide,
­(
5­(
bis(
2­(
acetyloxy)
ethyl)
amino)­
2­((
2­
bromo­
4,6­
dinitrophenyl)
azo)­
4­
methoxyphenyl)­

Structural
Class
 
Halogenated
cycloalkenes
77
 
47
 
4
1,3­
Cyclopentadiene,
1,2,3,4,5,5­
Hexachloro­

3734
 
48
 
3
4,7­
Methanoindene,
4,5,6,7,8,8­
hexachloro­
delta(
sup
1,5)­
tetrahydro­
(
chlordene)

62111
 
47
 
1
Heptachlorocyclopentene
Structural
Class
 
Halogenated
propanes
1070
 
78
 
6
1,1,1,3­
Tetrachloropropane
16714
 
68
 
4
1,1,2,2,3­
Pentachloropropane
Structural
Class
 
Hexachlorobicyclo[
2.2.1]
hept­
5­
ene­
2,3­
dicarboxy
compounds
115
 
27
 
5
4,7­
Methanoiosobenzofuran­
1,3­
dione,
4,5,6,7,8,8­
hexachloro­
3a,
4,7,7a­
tetrahydro
115
 
28
 
6
Chlorendic
acid
Structural
Class
 
Phosphoric
acid,
2­
chloroethyl
esters
13674
 
87
 
8
2­
Propanol,
1,3­
dichloro­,
phosphate
(
3:
1)

13204
 
14
 
8
2,2­
Bis(
chloromethyl)
trimethylene
bis(
bis(
2­
chloroethyl)
phosphate)

Structural
Class
 
Sulfonaphthyl­
substituted
4,1­
diazophenyl
compounds
8003
 
69
 
8
2­
Naphthalenesulfonic
acid,
6­((
7­
amino­
1­
hydroxy­
3­
sulfo­
2­
naphthalenyl)
azo)­
3­((
4­((
4­
amino­
6(
or
7)­
sulfo­
1­
naphthalenyl)
azo)
phenyl)
azo)­
4­
hydroxy­,
trisodium
salt
1670
 
62
 
6
Trisodium
6­((
2,4­
diaminophenyl)
azo)­
3­((
4­((
4­((
7­((
2,4­
diaminophenyl)
azo)­
1­
hydroxy­
3­
sulphonato­
2­
naphthyl)
azo)
phenyl)
amino)­
3­
sulphonatophenyl)
azo)­
4­
hydroxynaphthalene­
2­
sulphonate
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Notices
TABLE
3.
 
TWENTY­
EIGHT
EPA
HPV
CHALLENGE
PROGRAM
DEBITS
CHEMICALS
 
Continued
CAS
No.
Chemical
name
Structural
Class
 
Tetrachlorobenzenes
95
 
94
 
3
1,2,4,5­
Tetrachlorobenzene
634
 
66
 
2
1,2,3,4­
tetrachlorobenzene
Structural
Class
 
Tris(
aminoaryl)
methanamimnium
compounds
2152
 
64
 
9
Benzenamine,
­
phenyl­
4­((
4­(
phenylamino)
phenyl)(
4­(
phenylimino)­
2,5­
cyclohexadien­
1­
ylidene)
methyl)­,
monohydrochloride
101
 
20
 
2
Urea,
N­(
4­
Chlorophenyl)­
N'­(
3,4­
dichlorophenyl)­

719
 
32
 
4
Terephthaloyl
chloride,
tetrachloro­

433
 
06
 
3
1,1,2,2­
Tetrachloroethylsulfenyl
chloride
1203
 
86
 
7
2,2­
Dichloro­
1­(
2,4,5­
trichlorophenyl)­
ethanone
55954
 
19
 
3
1H­
Azepine­
1­
carboxamide,
N­(
3­(((
hexahydro­
2­
oxo­
1H­
azepin­
1­
yl)
carbonyl)
amino)
methyl)­
3,5,5­
trimethylcyclohexyl)
hexahydro­
2­
oxo­

60825
 
27
 
6
Acetic
acid,
((
3,5,6­
trichloro­
2­
pyridinyl)
oxy)­,
ethyl
ester
64667
 
33
 
0
Hexanoic
acid,
4,6,6,6­
tetrachloro­
3,3­
dimethyl­,
methyl
ester
69806
 
40
 
2
Propanoic
acid,
2­(
4­((
3­
chloro­
5­(
trifluoromethyl)­
2­
pyridinyl)
oxy)
phenoxy)­,
methyl
ester
TABLE
4.
 
TWO
HUNDRED
EIGHT
NON­
HPV
DEBITS
CHEMICALS
WITH
PREDICTED
BCFS
OF
3
 
13
CAS
No.
Chemical
name
Structual
Class
 
(
2­
Thiazolylazo)
benzenamines
19745
 
44
 
9
Propionitrile,
3­[
p­[(
5­
nitro­
2­
thiazolyl)
azo]­
N­
phenethylanilino]­

68516
 
81
 
4
Ethanol,
2­[
ethyl[
3­
methyl­
4­[(
5­
nitro­
2­
thiazolyl)
azo]
phenyl]
amino]­

70693
 
63
 
9
Benzenamine,
N,
N­
diethyl­
3­
methyl­
4­(
2­
thiazolylazo)­

Structual
Class
 
[
(
2­
Hydroxy­
1­
naphthalenyl)
azo]
benzenesulfonate
salts
12688
 
94
 
7
Manganese,
(
4­((
5­
chloro­
4­
methyl­
2­
sulfophenyl)
azo)­
3­
hydroxy­
2­
naphthalenecarboxylato(
2­))­

5070
 
41
 
8
2­
Naphthalenecarboxylic
acid,
4­((
5­
chloro­
4­
methyl­
2­
sulfophenyl)
azo)­
3­
hydroxy­,
strontium
salt
(
1:
1)

17852
 
99
 
2
Calcium
4­((
4­
chloro­
5­
methyl­
2­
sulphonatophenyl)
azo)­
3­
hydroxy­
2­
naphthoate
20514
 
68
 
1
2­
Naphthalenecarboxylic
acid,
4­((
4­
chloro­
5­
ethyl­
2­
sulfophenyl)
azo)­
3­
hydroxy­,
calcium
salt
(
1:
1)

67801
 
01
 
8
Barium
bis(
5­
chloro­
4­
ethyl­
2­((
2­
hydroxy­
1­
naphthyl)
azo)
benzenesulphonate)

67828
 
72
 
2
2­
Naphthalenecarboxylic
acid,
4­((
4­
chloro­
5­
methyl­
2­
sulfophenyl)
azo)­
3­
hydroxy­,
strontium
salt
(
1:
1)

Structual
Class
 
[
(
3,5­
Dinitro­
2­
thienyl)
azo]
anilines
14932
 
34
 
9
2,2'­(
4­((
3,5­
Dinitro­
2­
thienyl)
azo)­
4,1­
phenyleneimino)
bisethanol,
diacetate
(
ester)

58979
 
46
 
7
Acetamide,
N­[
5­(
diethylamino)­
2­[(
3,5­
dinitro­
2­
thienyl)
azo]
phenyl]­

Structual
Class
 
[
[
3­[(
Phenyl)
azo]
phenyl]
azo]
benzenes
4482
 
25
 
1
1,3­
Benzenediamine,
4,4'­(
4­
methyl­
1,3­
phenylene)
bis(
azo)
bis
6­
methyl­

5421
 
66
 
9
1,3­
Benzenediamine,
4,4'­((
4­
methyl­
1,3­
phenylene)
bis(
azo))
bis(
6­
methyl­,
dihydrochloride
67874
 
26
 
4
Benzoic
acid,
5­((
4­((
3­((
3­((
2,4­
diaminophenyl)
azo)­
2­
hydroxy­
5­
sulfophenyl)
azo)­
2,6­
dihydroxyphenyl)
azo)
phenyl)
azo)­
2­
hydroxy­,
disodium
salt
71799
 
74
 
1
2,7­
Naphthalenedisulfonic
acid,
4­((
2,4­
dihydroxy­
5­((
2­
hydroxy­
3,5­
dinitrophenyl)
azo)­
3((
4­
nitrophenyl)
azo)
phenyl)
azo)­
5­
hydroxy­

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No.
146
/
Tuesday,
July
30,
2002
/
Notices
TABLE
4.
 
TWO
HUNDRED
EIGHT
NON­
HPV
DEBITS
CHEMICALS
WITH
PREDICTED
BCFS
OF
3
 
13
 
Continued
CAS
No.
Chemical
name
Structual
Class
 
[
[
4­[(
Phenyl)
azo]
phenyl]
azo]
benzenesulfonic
acid
salts
51418
 
90
 
7
Benzenesulfonic
acid,
3­((
4­((
4­(
2­
hydroxybutoxy)­
3­
methylphenyl)
azo)­
3­
methoxyphenyl)
azo)­,
monosodium
salt
61290
 
31
 
1
Benzenesulfonic
acid,
3­((
4­((
4­(
2­
hydroxybutoxy)
phenyl)
azo)­
5­
methoxy­
2­
methylphenyl)
azo)­,
monolithium
salt
63405
 
85
 
6
Benzenesulfonic
acid,
3­[[
3­
methoxy­
4­[(
4­
methoxyphenyl)
azo]
phenyl]
azo]­,
sodium
68400
 
34
 
0
Benzenesulfonic
acid,
4­[[
4­[(
4­
hydroxyphenyl)
azo]­
5­
methoxy­
2­
methylphenyl]
azo­,
monosodium
salt]

68959
 
01
 
3
Benzenesulfonic
acid,
4­
chloro­
3­((
4­((
4­
ethoxyphenyl)
azo)
phenyl)
azo)­,
sodium
salt
Structual
Class
 
[
[
4­[(
Phenyl)
azo]
phenyl]
azo]
benzenesulfonic
acids
30282
 
44
 
1
Benzenesulfonic
acid,
p­[[
2,4­
dihyroxy­
3­(
xylylazo)
phneyl]
azo]­

Structual
Class
 
[
2­
Methoxy­
4­[(
3­
sulfophenyl)
azo]
phenyl]
urea
salts
7248
 
45
 
5
Benzoic
acid,
2­
hydroxy­
5­((
4­((((
2­
methoxy­
4­((
3­
sulfophenyl)
azo)
phenyl)
amino)
carbonyl)
amino)
phenyl)
azo)­,
disodium
salt
10114
 
86
 
0
3,3'­(
Carbonylbis(
imino(
3­
methoxy­
4,1­
phenylene)
azo))
bis(
benzenesulfonic
acid),
disodium
salt
Structual
Class
 
[
2­
Methoxy­
4­[(
3­
sulfophenyl)
azo]
phenyl]
ureas
8697
 
36
 
6
Benzenesulfonic
acid,
3,3'­(
carbonylbis(
imino(
3­
methoxy­
4,1­
phenylene)
azo))
bis­

Structual
Class
 
1­[(
Dinitrophenyl)
azo]­
2­
naphthalenols
4998
 
82
 
7
1­[(
2­
Hydroxy­
3,5­
dinitrophenyl)
azo]­
2­
hydroxynaphthalene
Structual
Class
 
1H­
Indole­
5­
sulfonic
acid,
2­
phenyl­
3­[[
2­(
phenylsulfonyl)
phenyl]
azo]­
1H­
Indole­
5­
sulfonic
acid
salts
90677
 
63
 
7
1H­
Indole­
5­
sulfonic
acid,
2­
phenyl­
3­[[
2­(
phenylsulfonyl)
phenyl]
azo]­,
monosodium
salt
Structual
Class
 
1H­
Indole­
5­
sulfonic
acid,
2­
phenyl­
3­[[
2­(
phenylsulfonyl)
phenyl]
azo]­
1H­
Indole­
5­
sulfonic
acids
93972
 
88
 
4
1H­
Indole­
5­
sulfonic
acid,
2­
phenyl­
3­[[
2­(
phenylsulfonyl)
phenyl]
azo]­

Structual
Class
 
2­(
Phenylazo)­
3­
oxo­
N­
phenylbutanamides
2512
 
29
 
0
Butanamide,
2­[(
4­
methyl­
2­
nitrophenyl)
azo]­
3­
oxo­
N­
phenyl­

6486­
21­
1
Acetoacetanilide,
2­[(
4­
methoxy­
2­
nitrophenyl)
azo]­

6486
 
23
 
3
Butanamide,
2[(
4­
chloro­
2­
nitrophenyl)
azo]­
N­(
2­
chlorophenyl)­
3­
oxo­

12225
 
18
 
2
Butanamide,
N­(
4­
chloro­
2,5­
dimethoxyphenyl)­
2­((
2,5­
dimethoxy­
4­((
phenylamino)
sulfonyl)
phenyl)
azo)­
3­
oxo­

13515
 
40
 
7
o­
Acetoacetanisidide,
2­[(
4­
chloro­
2­
nitrophenyl)
azo]­

32432
 
45
 
4
o­
Acetoacetotoluidide,
4'­
chloro­
2­[(
4­
chloro­
2­
nitrophenyl)
azo]­

52320
 
66
 
8
2­((
4­
Chloro­
2­
nitrophenyl)
azo)­
N­(
4­
ethoxyphenyl)­
3­
oxobutyramide
Structual
Class
 
2,4­
bis[(
Arylazo)
arylamino]­
6­
amino­
1,3,5­
triazines
104
 
03
 
8
2­
Naphthalenesulfonic
acid,
7,7'­((
6­(
4­
morpholinyl)­
1,3,5­
triazine­
2,4­
diyl)
diimino)
bis(
4­
hydroxy­
3­((
4­
methoxy­
2­
sulfophenyl)
azo)­,
tetrasodium
salt
50925
 
42
 
3
1,5­
Naphthalenedisulfonic
acid,
3,3'­((
6­((
2­
hydroxyethyl)
amino)­
1,3,5­
triazine­
2,4­
diyl)
bis(
imino(
2­
methyl­
4,1­
phenylene)
azo))
bis­,
tetrasodium
salt
52953
 
36
 
3
Cuprate(
4­),(
4­
hydroxy­
7­((
4­((
2­
hydroxyethyl)
amino)­
6­((
5­
hydroxy­
6­((
2­
hydroxy­
5­
sulfophenyl)
azo)­
7­
sulfo­
2­
naphthalenyl)
amino)­
1,3,5­
triazin­
2­
yl)
amino)­
3­((
4­
methoxy­
2­
sulfophenyl)
azo)­
2­
naphthalenesulfonato(
6­))­,
tetrasodium
Structual
Class
 
2­[[
6­[(
1,3,5­
Triazin­
2­
yl)
amino]­
1­
hydroxy­
3­
sulfo­
2­
naphthalenyl]
azo]­
1,5­
naphthalenedisulfonic
acid
salts
70616
 
90
 
9
1,5­
Naphthalenedisulfonic
acid,
2­((
6­((
4,6­
dichloro­
1,3,5­
triazin­
2­
yl)
methylamino)­
1­
hydroxy­
3­
sulfo­
2­
naphthalenyl)
azo)­,
trisodium
salt
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/
Vol.
67,
No.
146
/
Tuesday,
July
30,
2002
/
Notices
TABLE
4.
 
TWO
HUNDRED
EIGHT
NON­
HPV
DEBITS
CHEMICALS
WITH
PREDICTED
BCFS
OF
3
 
13
 
Continued
CAS
No.
Chemical
name
89923
 
44
 
4
Trisodium
2­((
6­((
4­(
ethylphenylamino­
6­
fluoro­
1,3,5­
triazin­
2­
yl)
amino)­
1­
hydroxy­
3­
sulphonato­
2­
naphthyl)
azo)
naphthalene­
1,5­
disulphonate
Structual
Class
 
2­
Azo­
N­(
2,3­
dihydro­
2­
oxo­
1H­
benzimidazol­
5­
yl)­
3­
oxobutanamides
12236
 
62
 
3
Butanamide,
2­((
4­
chloro­
2­
nitrophenyl)
azo)­
N­(
2,3­
dihydro­
2­
oxo­
1H­
benzimidazol­
5­
yl)­
3­
oxo­

68134
 
22
 
5
Butanamide,
­(
2,3­
dihydro­
2­
oxo­
1H­
benzimidazol­
5­
yl)­
3­
oxo­
2­((
2­(
trifluoromethyl)
phenyl)
azo)­

Structual
Class
 
2­
Halo­
4­(
phenylazo)­
6­
[(((
sulfonaphthyl)
azo)
sulfophenyl)
amino]­
1,3,5­
triazines
68110
 
31
 
6
2,7­
Naphthalenedisulfonic
acid,
4­
amino­
3,6­
bis((
4­((
4­
chloro­
6­((
3­
sulfophenyl)
amino)­
1,3,5­
triazin­
2­
yl)
amino)­
2­
sulfophenyl)
azo)­
5­
hydroxy­,
hexasodium
salt
68133
 
24
 
4
2,7­
Naphthalenedisulfonic
acid,
4­
amino­
3,6­
bis[[
5­[[
4­
chloro­
6­[(
3­
sulfophenyl)
amino]­
1,3,5­
triazin­
2­
yl]
amino]­
2­
sulfophenyl]
azo]­
5­
hydroxy­,
hexasodium
salt
70528
 
89
 
1
2,7­
Naphthalenedisulfonic
acid,
4­
amino­
6­((
5­((
4­((
3­
chlorophenyl)
amino)­
6­
fluoro­
1,3,5­
triazin­
2­
yl)
amino)­
2­
sulfophenyl)
azo)­
5­
hydroxy­
3­((
4­
sulfophenyl)
azo)­,
tetrasodium
salt
Structual
Class
 
3­[[
4­[(
6­
Nitro­
2­
benzothiazolyl)
azo]
phenyl]
amino]
propanenitriles
13486
 
43
 
6
Ethanol,
2­
ethyl­
4­(
6­
methoxy­
2­
benzothiazolyl)
azo
phenyl
amino­

16586
 
42
 
8
Propanenitrile,
3­
ethyl­
3­
methyl­
4­(
6­
nitro­
2­
benzothiazolyl)
azo
phenyl
amino­

16588
 
67
 
3
Propionitrile,
3­
N­
ethyl­
4­
6­(
methylsulfonyl)­
2­
benzothiazolyl
azo­,
m­
toluidino­

25510
 
81
 
0
Propanenitrile,
3­(
ethyl(
4­((
6­
nitro­
2­
benzothiazolyl)
azo)
phenyl)
amino)­

41362
 
82
 
7
Propanenitrile,
3­
4­(
5,6­
dichloro­
2­
benzothiazolyl)
azo
phenyl
methylamino­

Structual
Class
 
3­[[
4­[(
Phenyl)
azo]­
1­
naphthalenyl]
azo]
benzenesulfonic
acids,
sodium
salts
67875
 
21
 
2
Benzenesulfonic
acid,
3­[[
4­[(
2­
hydroxy­
5­
methylphenyl)
azo]­
1­
naphthalenyl]
azo]­,
monosodium
salt
68959
 
00
 
2
Benzenesulfonic
acid,
3­((
4­((
2­
ethoxy­
5­
methylphenyl)
azo)­
1­
naphthalenyl)
azo)­,
sodium
salt
Structual
Class
 
3­[[
Phenyl]
azo]­
N­(
phenyl)
benzenecarboxamides
12236
 
64
 
5
2­
Naphthalenecarboxamide,
­(
4­(
acetylamino)
phenyl)­
4­((
5­(
aminocarbonyl)­
2­
chlorophenyl)
azo)­
3­
hydroxy­

36968
 
27
 
1
2­
Naphthalenecarboxamide,
4­[[
4­(
aminocarbonyl)
pohenyl]
azo]­
3­
hydroxy­
N­(
2­
methoxyphenyl)­

19904
 
51
 
4
2­
Naphthalenecarboxamide,
3­
hydroxy­
4­((
2­
methoxy­
5­((
phenylamino)
carbonyl)
phenyl)
azo)­

Structual
Class
 
4,4'­
bis(
Arylazo)
stilbene­
2,2'­
disulfonic
acid
salts
2870
 
32
 
8
2,2'­(
1,2­
Ethenediyl)
bis(
5­((
4­
ethoxyphenyl)
azo)
benzenesulfonic
acid),
disodium
salt
53523
 
90
 
3
Benzoic
acid,
3,3'­[
1,2­
ethenediylbis[(
3­
sulfo­
4,1­
phenylene)
azo]]
bis
[
6­
hydroxy­
5­
methyl­,
tetralithium
salt
75701
 
34
 
7
2­
Naphthalenesulfonic
acid,
3,3'­[
1,2­
ethenediylbis[(
3­
sulfo­
4,1­
phenylene)
azo]]
bis[
6­
amino­
4­
hydroxy­,
cmpd
with
2,2',
2''­
nitrilotris
(
ethanol)
(
1:
4)

Structual
Class
 
4,4'­
bis(
Arylazo)
stilbene­
2,2'­
disulfonic
acids
91
 
34
 
9
Benzenesulfonic
acid,
2,2'­(
1,2­
ethenediyl)
bis
5­(
4­
hydroxyphenyl)
azo­

Structual
Class
 
4,4'­
bis(
Triazinylamino)
stilbene­
2,2'­
disulfonic
acid
salts
37138
 
26
 
4
Benzenesulfonic
acid,
2,2'­(
1,2­
ethenediyl)
bis[
5­[[
4­
chloro­
6­[(
4­
sulfophenyl)
amino]­
1,3,5­
triazin­
2­
yl]
amino]­,
tetrasodium
salt
41098
 
56
 
0
1,4­
Benzenedisulfonic
acid,
2,2'­(
1,2­
ethenediylbis((
3­
sulfo­
4,1­
phenylene)
imino(
6­(
diethylamino)­
1,3,5­
triazine­
4,2­
diyl)
imino))
bis­,
hexasodium
salt
17506
 
54
 
5
Benzenesulfonic
acid,
2,2'­(
1,2­
ethenediyl)
bis(
5­((
4­(
bis(
2­
hydroxypropyl)
amino)­
6­((
4­
sulfophenyl)
amino)­
1,3,5­
triazin­
2­
yl)
amino)­,
dipotassium
disodium
salt
68003
 
30
 
5
Benzenesulfonic
acid,
2,2'­(
1,2­
ethenediyl)
bis(
5­((
4­(
2­
hydroxypropoxy)­
6­(
phenylamino)­
1,3,5­
triazin­
2­
yl)
amino)­,
disodium
salt
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Notices
TABLE
4.
 
TWO
HUNDRED
EIGHT
NON­
HPV
DEBITS
CHEMICALS
WITH
PREDICTED
BCFS
OF
3
 
13
 
Continued
CAS
No.
Chemical
name
68003
 
31
 
6
Benzenesulfonic
acid,
2,2'­(
1,2­
ethenediyl)
bis[
5­[[
4­[
2­(
2­
hydroxyethoxy)
ethoxy]­
6­[
phenylamino]­
1,3,5­
triazin­
2­
yl]
amino]­,
disodium
salt
68025
 
20
 
7
Benzenesulfonic
acid,
5­((
4­(
2­(
2­
hydroxyethoxy)
ethoxy)­
6­(
phenylamino)­
1,3,5­
triazin­
2­
yl)
amino)­
2­(
2­(
4­((
4­
(
2­
hydroxypropoxy)­
6­(
phenylamino)­
1,3,5­
triazin­
2­
yl)
amino)­
2­
sulfophenyl)
ethenyl)­,
disodium
salt
68155
 
68
 
0
Benzenesulfonic
acid,
2,2'­(
1,2­
ethenediyl)
bis(
5­((
4­
chloro­
6­((
4­
sulfophenyl)
amino)­
1,3,5­
triazin­
2­
yl)
amino)­,
dipotassium
disodium
salt
85187
 
74
 
2
Benzenesulfonic
acid,
2,2'­(
1,2­
ethenediyl)
bis(
5­((
4­(
methylamino)­
6­
(
phenylamino)­
1,3,5­
triazin­
2­
yl)
amino)­,
sodium
salt
Structual
Class
 
4­
Amino­
4'­
nitroazobenzenes
101
 
52
 
0
2­
Methoxy­
4­[(
4­
nitrophenyl)
azo]
benzenamine
1533
 
76
 
2
Propanamide,
­(
5­(
bis(
2­(
acetyloxy)
ethyl)
amino)­
2­((
4­
nitrophenyl)
azo)
phenyl)­

1533
 
77
 
3
Acetanilide,
5'­(
bis(
2­
hydroxyethyl)
amino)­
2'­((
2­
methoxy­
4­
nitrophenyl)
azo)­,
diacetate
(
ester)

1533
 
78
 
4
Acetamide,
­(
5­(
bis(
2­(
acetyloxy)
ethyl)
amino)­
2­((
2­
chloro­
4­
nitrophenyl)
azo)
phenyl)­

2872
 
52
 
8
2­(
Ethyl(
4­((
4­
nitrophenyl)
azo)
phenyl)
amino)
ethanol
3025
 
41
 
0
Ethanol,
2,2'­
4­(
2­
chloro­
4­
nitrophenyl)
azo
phenyl
imino
bis­

3179
 
89
 
3
Ethanol,
2,2'­
3­
methyl­
4­(
4­
nitrophenyl)
azo
phenyl
imino
bis­

3180
 
81
 
2
Ethanol,
2­,
4­(
2­
chloro­
4­
nitrophenyl)
azo
phenyl
ethylamino­

3618
 
73
 
3
Acetamide,
­(
5­(
bis(
2­(
acetyloxy)
ethyl)
amino)­
2­((
2­
chloro­
4,6­
dinitrophenyl)
azo)­
4­
methoxyphenyl)­

4058
 
30
 
4
Propanenitrile,
3,3'­((
4­((
2­
chloro­
4­
nitrophenyl)
azo)
phenyl)
imino)
bis­

5261
 
31
 
4
Propanenitrile,
3­((
2­(
acetyloxy)
ethyl)(
4­((
2,6­
dichloro­
4­
nitrophenyl)
azo)
phenyl)
amino)­

6021
 
61
 
0
Propionitrile,
3­[
p­[(
2­
chloro­
4­
nitrophenyl)
azo]­
N­(
2­
hydroxyethyl)
anilino]­,

6657
 
32
 
5
Propionitrile,
3­[
N­(
2­
hydroxyethyl)­
p­[(
p­
nitrophenyl)
azo]
anilino]­

13301
 
61
 
6
Propionitrile,
3­[
p­[(
2,6­
dichloro­
4­
nitrophenyl)
azo]­
N­
ethylanilino]­

16586
 
43
 
9
Propanenitrile,
3­[[
4­[(
2­
chloro­
4­
nitrophenyl)
azo]­
3­
methylphenyl]
ethylamino]­

5474
 
89
 
3
Benzonitrile,
2­[[
p­[(
2­
cyanoethyl)
ethylamino]
phenyl]
azo]­
5­
nitro­

17464
 
91
 
4
Ethanol,
2,2'­((
4­((
2­
bromo­
6­
chloro­
4­
nitrophenyl)
azo)­
3­
chlorophenyl)
imino)
bis­

17741
 
62
 
7
Thiomorpholine,
4­
p­(
2,6­
dichloro­
4­
nitrophenyl)
azo
phenyl­,
1,1­
dioxide
22578
 
86
 
5
Acetamide,
N­(
2­((
2­
bromo­
4,6­
dinitrophenyl)
azo)­
5­((
2­
cyanoethyl)
ethylamino)­
4­
methoxyphenyl)­

23355
 
64
 
8
Ethanol,
2,2'­[[
3­
chloro­
4­[(
2,6­
dichloro­
4­
nitrophenyl)
azo]
phenyl]
imino]
di­

24170
 
60
 
3
Acetamide,
N­
2­(
2­
cyano­
4,6­
dinitrophenyl)
azo­
5­(
diethylamino)
phenyl­

29426
 
52
 
6
Ethanol,
2,2'­
3­
methyl­
4­
2­(
methylsulfonyl)­
4­
nitrophenyl
azo
phenyl
imino
bis­,
diacetate
ester
29649
 
47
 
6
Acetamide,­(
2­((
2­
chloro­
4­
nitrophenyl)
azo)­
5­((
2­(
2,5­
dioxo­
1­
pyrrolidinyl)
ethyl)
ethylamino)
phenyl)­

10177
 
47
 
6
Benzamide,
N­
5­
bis
2­(
acetyloxy)
ethyl
amino­
2­(
4­
nitrophenyl)
azo
phenyl­

30124
 
94
 
8
Benzonitrile,
2­
4­
bis
2­(
acetyloxy)
ethyl
amino
phenyl
azo­
5­
nitro­

31464
 
38
 
7
Propanenitrile,
3­
methyl­
4­(
4­
nitrophenyl)
azo
phenyl
amino­

31482
 
56
 
1
Propanenitrile,
3­
ethyl­
4­(
4­
nitrophenyl)
azo
phenyl
amino­

40690
 
89
 
9
Propanenitrile,
3­[[
2­(
benzoyloxy)
ethyl][
4­[(
4­
nitrophenyl)
azo]
phenyl]
amino]­

40880
 
51
 
1
Propanenitrile,
3­
4­(
2­
chloro­
4­
nitrophenyl)
azo
phenyl
ethylamino­

41642
 
51
 
7
Acetamide,
­
2­(
2,6­
dicyano­
4­
nitrophenyl)
azo­
5­(
diethylamino)
phenyl­

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No.
146
/
Tuesday,
July
30,
2002
/
Notices
TABLE
4.
 
TWO
HUNDRED
EIGHT
NON­
HPV
DEBITS
CHEMICALS
WITH
PREDICTED
BCFS
OF
3
 
13
 
Continued
CAS
No.
Chemical
name
43047
 
20
 
7
Ethanol,
2,2­
chloro­
4­(
4­
nitrophenyl)
azo
phenyl
amino­

52697
 
38
 
8
Acetamide,
­[
2­[(
2­
bromo­
4,6­
dinitrophenyl)
azo]­
5­(
diethylamino)
phenyl]­

53950
 
33
 
7
Acetamide,
­(
2­((
2­
bromo­
4,6­
dinitrophenyl)
azo)­
5­((
2­
cyanoethyl)
amino)­
4­
methoxyphenyl)­

56548
 
64
 
2
Acetamide,
­[
2­[(
2­
bromo­
4,6­
dinitrophenyl)
azo]­
5­(
diethylamino)­
4­
methoxyphenyl)­

61355
 
92
 
8
.
beta.­
Alanine,
­
3­(
acetylamino)­
4­
(
4­
nitrophenyl)
azo
phenyl
­
N­(
3­
methoxy­
3­
oxopropyl)­,
methyl
ester
22487049
Ethanol,
2,2'­
4­(
2,6­
dichloro­
4­
nitrophenyl)
azo
phenyl
imino
bis­

65916
 
12
 
3
Acetamide,
­(
2­((
2,6­
dicyano­
4­
nitrophenyl)
azo)­
5­((
2­(
2­
ethoxyethoxy)
ethyl)
ethylamino)
phenyl)­

66214
 
54
 
8
Ethanol,
2,2'­
4­(
4­
nitrophenyl)
azo
phenyl
imino
bis­,
diacetate
(
ester)

66882
 
16
 
4
Benzonitrile,
2­[[
4­[
bis[
2­(
acetyloxy)
ethyl]
amino]­
2­
methylphenyl]
azo]­
5­
nitro­

67674
 
22
 
0
Acetamide,
­
2­(
2­
bromo­
4,6­
dinitrophenyl)
azo­
5­(
ethylamino)­
4­
methoxyphenyl­

67846
 
62
 
2
Propanamide,
­(
2­((
2­
chloro­
4,6­
dinitrophenyl)
azo)­
5­(
ethylamino)­
4­(
2­
methoxyethoxy)
phenyl)­

67874
 
57
 
1
Propanenitrile,
3­
2­
chloro­
4­(
2,6­
dichloro­
4­
nitrophenyl)
azo
phenyl
amino­

67923
 
43
 
7
Propanenitrile,
3,3'­
4­
(
2,6­
dichloro­
4­
nitrophenyl)
azo
phenyl
imino
bis­

68391
 
42
 
4
Propanenitrile,
3­[[
2­(
acetyloxy)
ethyl][
4­[(
4­
nitrophenyl)
azo]
phenyl]
amino]­

68391
 
47
 
9
Acetamide,
N­
5­
bis­
2­(
acetyloxy)
ethyl
amino­
2­(
2,4­
dinitrophenyl)
azo
phenyl­

68957
 
67
 
5
Acetamide,
N­(
2­((
2­
chloro­
4,6­
dinitrophenyl)
azo)­
5­(
ethylamino)­
4­(
2­
methoxyethoxy)
phenyl)­

70210
 
10
 
5
Propanenitrile,
3­((
2­(
2­
cyanoethoxy)
ethyl)(
4­((
4­
nitrophenyl)
azo)
phenyl)
amino)­

71617
 
28
 
2
Acetamide,
N­(
4­
chloro­
2­((
2­
chloro­
4­
nitrophenyl)
azo)­
5­((
2­
hydroxypropyl)
amino)
phenyl)­

72968
 
78
 
6
2,4,10­
Trioxa­
7­
azaundecan­
11­
oic
acid,
7­(
4­((
2­
cyano­
4­
nitrophenyl)
azo)­
3­
methylphenyl)­
3­
oxo­,
methyl
ester
75150
 
11
 
7
Acetamide,
­(
2­((
2­
chloro­
4­
nitrophenyl)
azo)­
5­((
2­
cyanoethyl)­
2­
propenylamino)
phenyl)­

Structual
Class
 
5­(
Phenylazo)­
8­(
phenylamino)­
1­
naphthalenesulfonic
acid
salts
67875
 
18
 
7
1­
Naphthalenesulfonic
acid,
5­((
2­
chloro­
4­
nitrophenyl)
azo)­
8­
phenylamino­,
sodium
salt
67875
 
11
 
0
1­
Naphthalenesulfonic
acid,
5­[(
3­
chlorophenyl)
azo]­
8­(
phenylamino)­,
monosodium
Structual
Class
 
5,8­
bis(
phenylazo)­
2­
sulfonaphthalenes
67875
 
14
 
3
2­
Naphthalenesulfonic
acid,
5­((
4­(
bis(
2­
hydroxyethyl)
amino)
phenyl)
azo)­
8­((
2­
methylphenyl)
azo)­,
monosodium
salt
68039
 
07
 
6
2­
Naphthalenesulfonic
acid,
5(
or
8)­((
4­
hydroxy­
2­
methylphenyl)
azo)­
8(
or
5)­(
phenylazo)­,
monosodium
salt
68039
 
08
 
7
2­
Naphthalenesulfonic
acid,
5(
or
8)­((
4­
ethoxy­
2­
methylphenyl)
azo)­
8(
or
5)­(
phenylazo)­,
sodium
salt
Structual
Class
 
5,8­
bis[(
naphthyl
or
phenyl)
azo]­
2­
sulfonaphthalenes
4399
 
55
 
7
1,5­
Naphthalenedisulfonic
acid,
3­((
4­((
4­((
6­
amino­
1­
hydroxy­
3­
sulfo­
2­
naphthalenyl)
azo)­
6­
sulfo­
1­
naphthalenyl)
azo)­
1­
naphthalenyl)
azo)­,
tetrasodium
salt
68227
 
72
 
5
1­
Naphthalenesulfonic
acid,
8­(
phenylamino)­
5­((
4­(
phenylazo)­
6­
sulfo­
1­
naphthalenyl)
azo)­,
disodium
salt
70210
 
31
 
0
2­
Naphthalenesulfonic
acid,
8­((
4­((
4­
amino­
3­
sulfophenyl)
azo)­
6­
sulfo­
1­
naphthalenyl)
azo)­
5­((
6­
(
benzoylamino)­
1­
hydroxy­
3­
sulfo­
2­
naphthalenyl)
azo)­,
tetrasodium
salt
Structual
Class
 
5­[[
4­[(
3­
Sulfophenyl)
azo]­
1­
naphthalenyl]
azo]
naphthalene
sulfonic
acid
salts
530
 
08
 
7
1­
Naphthalenesulfonic
acid,
8­(
phenylamino)­
5­((
4­((
3­
sulfophenyl)
azo)­
1­
naphthalenyl)
azo)­,
disodium
salt
1593
 
37
 
1
2­
Naphthalenesulfonic
acid,
6­
hydroxy­
5­((
4­((
4­(
phenylamino)­
3­
sulfophenyl)
azo)­
1­
naphthalenyl)
azo)­
,
disodium
salt
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/
Vol.
67,
No.
146
/
Tuesday,
July
30,
2002
/
Notices
TABLE
4.
 
TWO
HUNDRED
EIGHT
NON­
HPV
DEBITS
CHEMICALS
WITH
PREDICTED
BCFS
OF
3
 
13
 
Continued
CAS
No.
Chemical
name
Structual
Class
 
5­
Azo­
2,6­
dialkylamino­
4­
methyl­
3­
pyridinecarbonitriles
63833
 
78
 
3
3­
Pyridinecarbonitrile,
5­
(
2­
cyano­
4­
nitrophenyl)
azo
­
6­
(
2­
hydroxyethyl)
amino
72968
 
71
 
9
2­
Thiophenecarboxylic
acid,
4­
cyano­
5­((
5­
cyano­
2,6­
bis((
3­
methoxypropyl)
amino)­
4­
methyl­
3­
pyridinyl)
azo)­
3­
methyl­,
methyl
ester
Structual
Class
 
Azobis(
4,1­
phenyleneazo)
bis(
naphthalenesulfonates)

52469
 
75
 
7
Trisodium
5­
amino­
3­((
4­((
4­((
7­
amino­
1­
hydroxy­
3­
sulphonato­
2­
naphthyl)
azo)
phenyl)
azo)
phenyl)
azo)­
4­
hydroxynaphthalene­
2,7­
disulphonate
72017
 
89
 
1
2,7­
Naphthalenedisulfonic
acid,
3,3'­(
azobis(
4,1­
phenyleneazo))
bis(
5­
amino­
4­
hydroxy­,
tetrasodium
salt
72017
 
91
 
5
2,7­
Naphthalenedisulfonic
acid,
5­
amino­
3­((
4­((
4­((
8­
amino­
1­
hydroxy­
3,6­
disulfo­
2­
naphthalenyl)
azo)­
3­
methoxyphenyl)
azo)
phenyl)
azo)­
4­
hydroxy­,
tetrasodium
salt
75173
 
68
 
1
Copper,
(
mu­((
3,3'­(
azoxybis((
2­
hydroxy­
4,1­
phenylene)
azo))
bis(
4­
hydroxy­
2,7­
naphthalenesulfonato))(
8­)))
di­,
tetrasodium
93941
 
06
 
1
2,7­
Naphthalenedisulfonic
acid,
3,3'­(
azoxybis((
2­
methoxy­
4,1­
phenylene)
azo))
bis(
4,5­
dihydroxy­

99869
 
36
 
0
2,7­
Naphthalenedisulfonic
acid,
3,3'­(
azoxybis((
2­
methoxy­
4,1­
phenylene)
azo))
bis(
4,5­
dihydroxy­,
lithium
salt
99869
 
37
 
1
2,7­
Naphthalenedisulfonic
acid,
3,3'­(
azoxybis((
2­
methoxy­
4,1­
phenylene)
azo))
bis(
4,5­
dihydroxy­,
sodium
salt
124605
 
82
 
9
2,7­
Naphthalenedisulfonic
acid,
5­
amino­
3­[[
4­[[
4­[(
8­
amino­
1­
hydroxy­
3,6­
disulfo­
2­
naphthalenyl)
azo]­
2­
methylphenyl]
azo]­
4­
hydroxy­,
lithium
sodium
salt
Structual
Class
 
Biphenylbis(
azonaphthalenesulfonates)

4198
 
19
 
0
2,7­
Naphthalenedisulfonic
acid,
3,3'­((
3,3'­
dimethoxy(
1,1'­
biphenyl)­
4,4'­
diyl)
bis(
azo))
bis(
4,5­
dihydroxy­,
tetrasodium
salt
3770
 
03
 
3
Cuprate(
4­),
(
mu­((
4,4'­((
3,3'­
di(
hydroxy­
kappaO)(
1,1'­
biphenyl)­
4,4'­
diyl)
bis(
azo­
kappaN1))
bis(
3­(
hydroxykappaO
2,7­
naphthalenedisulfonato))(
8­)))
di­,
tetrasodium
28407
 
37
 
6
2,7­
Naphthalenedisulfonic
acid,
3,3'((
3,3'­
dihydroxy(
1,1'­
biphenyl)­
4,4'­
diyl)
bis(
azo)
bis(
5­
amino­
4­
hydroxy­,
sodium
salt,
copper
complex
66418
 
17
 
5
Cuprate(
3­),
[.
mu.­[
4­[[
4'­[(
6­
amino­
1­
hydroxy­
3­
sulfo­
2­
naphthalenyl)
azo]­
3,3'­
dihydroxy(
1,1'­
biphenyl)­
4­
yl)
azo]­
3­
hydroxy­
2,7­
naphthalene
disulfonato(
7­)]]
di­,
trisodium
67952
 
80
 
1
Cuprate(
4­),
(
mu­(
5­(
acetylamino)­
3­((
4'­((
8­
amino­
1­
hydroxy­
3,6­
disulfo­
2­
naphthalenyl)
azo)­
3,3'­
dihydroxy(
1,1'­
biphenyl)­
4­
yl)
azo)­
4­
hydroxy­
2,7­
naphthalenedisulfonato(
8­)))
di­,
tetrasodium
68133
 
82
 
4
Chromate(
2­),
bis(
2­((
6­
amino­
1­
hydroxy­
3­
sulfo­
2­
naphthalenyl)
azo)
benzoato(
3­))­,
dihydrogen
68259
 
04
 
1
Acetic
acid,
2,2'­((
4,4'­
bis((
6­((
1­
hydroxy­
4­(((
2­
methoxyethoxy)
carbaryl)
amino)
phenyl)
amino)­
3­
sulfo­
2­
naphthalenyl)
azo(
1,1'­
biphenyl)­
3,3'­
diyl)
bis(
oxy))
bis­,
disodium
salt
71550
 
22
 
6
2,7­
Naphthalenedisulfonic
acid,
3,3'­((
3,3'­
dimethoxy(
1,1'­
biphenyl)­
4,4'­
diyl)
bis(
azo))
bis(
5­
amino­
4­
hydroxy­,
tetralithium
salt
71873
 
63
 
7
Cuprate(
4­),
[.
mu.­[
7­[[
3,3'­
dihydroxy­
4'­[(
4­
hydroxy­
2­
sulfobenzo[
a]
phenazin­
3­
yl)
azo­
kappaN1)(
1,1'­
biphenyl)­
4­
yl)
azo­
kappaN1)­
8­(
hydrozy­
kappa0)­
1,3,6­
naphthalenetrisulfonato(
8­)))
di­,
tetrasodium
salt
Structual
Class
 
Bis[
1',
2'­
dihydro­
6'­
hydroxy­
4'­
methyl­
2'­
oxo­
1,3'­
bipyridiniums]

71032
 
99
 
0
1,3'­
Bipyridinium,
5',
5'''­(
1,2­
ethanediylbis(
4,1­
phenyleneazo))
bis(
1',
2'­
dihydro­
6'­
hydroxy­
4'­
methyl­
2'­
oxo­,
salt
with
2­
hydroxypropanoic
acid
(
1:
2)

75214
 
63
 
0
1,3'­
Bipyridinium,
5'­[[
4­[[
4­[(
1',
2'­
dihydro­
6'­
hydroxy­
3,4'­
dimethyl­
2'­
oxo[
1,3'­
bipyridinium)­
5'­
yl)
azo)
benzoyl)
amino)
phenyl)
azo)­
1',
3'­
dihydro­
6'­
hydroxy­
3,4'­
dimethyl­
2'­
oxo­,
salt
with
2­
hydroxypropanoic
acid
(
1:
2)

Structual
Class
 
Bis[
2­(
phenylazo)­
3­
oxo­
N­
phenylbutanamides]

6505
 
28
 
8
Butanamide,
2,2'­((
3,3'­
dimethoxy(
1,1'­
biphenyl)­
4,4'­
diyl)
bis(
azo))
bis(
3­
oxo­
N­
phenyl­

7147
 
42
 
4
Butanamide,
2,2'­((
3,3'­
dimethoxy(
1,1'­
biphenyl)­
4,4'­
diyl)
bis(
azo))
bis(
N­(
2­
methylphenyl)­
3­
oxo­

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Notices
TABLE
4.
 
TWO
HUNDRED
EIGHT
NON­
HPV
DEBITS
CHEMICALS
WITH
PREDICTED
BCFS
OF
3
 
13
 
Continued
CAS
No.
Chemical
name
68155
 
71
 
5
Benzamide,
4­((
1­(((
2­
methoxyphenyl)
amino)
carbonyl)­
2­
oxopropyl)
azo)­
N­(
4­((
1­(((
2­
methoxyphenyl)
amino)
carbonyl)­
2­
oxopropyl)
azo)
phenyl)­

68516
 
73
 
4
1,4­
Benzenedicarboxylic
acid,
2,2'­[
1,4­
phenylenebis[
imino(
1­
acetyl­
2­
oxo­
2,1­
ethanediyl)
azo))
bis­,
tetramethyl
ester
77804
 
81
 
0
Butanamide,
2,2'­(
1,2­
ethanediylbis(
oxy­
2,1­
phenyleneazo))
bis(
N­
(
2,3­
dihydro­
2­
oxo­
1H­
benzimidazol­
5­
yl)­
3­
oxo­

Structual
Class
 
Diaminoanthraquinones
4403
 
90
 
1
m­
Toluenesulfonic
acid,
6,6'­(
1,4­
anthraquinonylenediimino)
di­,
disodium
salt
67827
 
60
 
5
2­
Anthracenesulfonic
acid,
1­
amino­
4­((
3­((
benzoylamino)
methyl)­
2,4,6­
trimethylphenyl)
amino)­
9,10­
dihydro­
9,10­
dioxo­,
monosodium
salt
67969
 
88
 
4
2­
Anthracenesulfonic
acid,
1­
amino­
4­((
4­(((
4­
methylphenyl)
sulfonyl]
oxy]
phenyl)
amino)­
9,10­
dihydro­
9,10­
dioxo­,
monosodium
salt
67970
 
27
 
8
Benzenesulfonic
acid,
2,2'­((
9,10­
dihydro­
9,10­
dioxo­
1,4­
anthracenediyl)
diimino)
bis(
5­
methyl­,
diammonium
salt
72391
 
24
 
3
Benzenesulfonic
acid,
[[(
chloroacetyl)
amino]
methyl][
4­[[
4­(
cyclohexylamino)­
9,10­
dioxo­
1­
anthracenyl)
amino)
phenoxy)
methyl­,
monosodium
salt
Structual
Class
 
N­(
2,3­
dihydro­
2­
oxo­
1H­
benzimidazol­
5­
yl)­
4­
[[
4­[(
methylamino)
sulfonyl]
phenyl]
azo]­
3­
hydroxy­
2­
naphthalenecarboxamides
3771
 
33
 
9
2­
Naphthalenecarboxamide,
­(
2,3­
dihydro­
2­
oxo­
1H­
benzimidazol­
5­
yl)­
4­((
2,5­
dimethoxy­
4­
((
methylamino)
sulfonyl)
phenyl)
azo)­
3­
hydroxy­

Structual
Class
 
­(
2,3­
dihydro­
2­
oxo­
1H­
benzimidazol­
5­
yl)­
4­
[[
4­[(
methylamino)
sulfonyl]
phenyl]
azo]­
3­
hydroxy­
2­
naphthalenecarboxamides
18269
 
75
 
6
2­
Naphthalenecarboxamide,­(
2,3­
dihydro­
2­
oxo­
1H­
benzimidazol­
5­
yl)­
3­
hydroxy­
4­((
2­
methoxy­
5­
methyl­
4­
((
methylamino)
sulfonyl)
phenyl)
azo)­

61951
 
98
 
2
N­(
2,3­
Dihydro­
2­
oxo­
1H­
benzimidazol­
5­
yl)­
3­
hydroxy­
4­((
5­
methoxy­
2­
methyl­
4­
((
methylamino)
sulphonyl)
phenyl)
azo)
naphthalene­
2­
carboxamide
Structual
Class
 
N­(
arylazo)
phenyl
(
disulfonaphthyl)
azobenzamides
70900
 
28
 
6
2,7­
Naphthalenedisulfonic
acid,
4­
amino­
3­((
4­(((
4­((
4­
amino­
2­
hydroxyphenyl)
azo)
phenyl)
amino)
carbonyl)
phenyl)
azo)­
5­
hydroxy­
6­((
4­
sulfophenyl)
azo)­,
trisodium
salt
72245
 
55
 
7
2,7­
Naphthalenedisulfonic
acid,
4­
amino­
3­((
4­(((
4­((
7­
amino­
1­
hydroxy­
3­
sulfo­
2­
naphthalenyl)
azo)
phenyl)
amino)
carbonyl)
phenyl)
azo)­
5­
hydroxy­
6­(
phenylazo)­,
sodium
salt
72245
 
57
 
9
2,7­
Naphthalenedisulfonic
acid,
4­
amino­
3­((
4­(((
4­((
2­
amino­
4­
hydroxyphenyl)
azo)
phenyl)
amino)
carbonyl)
phenyl)
azo)­
5­
hydroxy­
6­(
phenylazo)­,
sodium
salt
Structual
Class
 
N,
N'­
bis[(
arylazo)
sulfonaphthyl]
urea
salts
3441
 
14
 
3
2­
Naphthalenesulfonic
acid,
3­((
4­(
acetylamino)
phenyl)
azo)­
4­
hydroxy­
7­((((
5­
hydroxy­
6­(
phenylazo)­
7­
sulfo­
2­
naphthalenyl)
amino)
carbonyl)
amino)­,
disodium
salt
3626
 
36
 
6
2­
Naphthalenesulfonic
acid,
7,7'­(
carbonyldiimino)
bis(
4­
hydroxy­
3­(
phenylazo)­,
disodium
salt
79255
 
95
 
1
2­
Naphthalenesulfonic
acid,
7,7'­(
carbonyldiimino)
bis(
4­
hydroxy­
3­((
2­
methyl­
4­
sulfophenyl)
azo)­,
sodium
salt,
compd.
with
2,2',
2''­
nitrilotris(
ethanol)

Structual
Class
 
N­[
2­[(
2,6­
dicyano­
4­
methylphenyl)
azo]­
5­(
dialkylamino)
phenyl]
methanesulfonamides
68385
 
96
 
6
Methanesulfonamide,
­[
2­[(
2,6­
dicyano­
4­
methylphenyl)
azo]­
5­(
diethylamino)
phenyl]­

72968
 
82
 
2
Methanesulfonamide,
N­
2­(
2,6­
dicyano­
4­
methylphenyl)
azo­
5­(
dipropylamino)
phenyl
Structual
Class
 
N­[
5­(
amino)­
2­[[
5­(
ethylthio)­
1,3,4­
thiadiazol­
2­
yl]
azo]
phenyl]
acetamides
63134
 
15
 
6
Acetamide,
­
5­(
dipropylamino)­
2­
5­(
ethylthio)­
1,3,4­
thiadiazol­
2­
ylazo
phenyl­

67338
 
62
 
9
Acetamide,
­(
5­(
ethyl(
phenylmethyl)
amino)­
2­((
5­(
ethylthio)­
1,3,4­
thiadiazol­
2­
yl)
azo)
phenyl)­

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/
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30,
2002
/
Notices
TABLE
4.
 
TWO
HUNDRED
EIGHT
NON­
HPV
DEBITS
CHEMICALS
WITH
PREDICTED
BCFS
OF
3
 
13
 
Continued
CAS
No.
Chemical
name
Structual
Class
 
Sulfonaphthyl­
substituted
4,1­
diazophenyl
compounds
20025
 
74
 
5
1,3,5­
Naphthalenetrisulfonic
acid,
7­((
4­((
4­((
2,5,6­
trichloro­
4­
pyrimidinyl)
amino)
phenyl)
azo)
phenyl)
azo)­,
trisodium
salt
68460
 
07
 
1
2,7­
Naphthalenedisulfonic
acid,
4­
amino­
3­[[
4­[(
2­
amino­
4­
hydroxyphenyl)
azo]
phenyl]
azo]­
5­
hydroxy­
6­
(
phenylazo)­,
disodium
salt
124649
 
82
 
7
2­
Naphthalenesulfonic
acid,
4­
hydroxy­
3­[[
2­
methoxy­
5­
methyl­
4­[(
4­
sulfophenyl)
azo]
phenyl]
azo]­
7­
(
phenylamino)­,
cmpd.
with
[
nitrilotris(
2,1­
ethanediyloxy)]
tris[
propanol]
(
1:
2)

Structual
Class
 
Sulfonaphthyl­
substituted
diphenylamine­
4,4'­
diazo­
2­
sulfonic
acid
salts
67969
 
92
 
0
2­
Naphthalenesulfonic
acid,
6­
amino­
3­[[
4­[[
4­[(
7­
amino­
1­
hydroxy­
3­
sulfo­
2­
naphthalenenyl]
azo]
phenyl]
amino]­
3­
sulfophenyl]
azo]­
4­
hydroxy­,
trisodium
salt
Structual
Class
 
Sulfonaphthyl­
substituted
diphenylamine­
4,4'­
diazo­
2­
sulfonic
acids
72066
 
88
 
7
2,7­
Naphthalenedisulfonic
acid,
4­
amino­
3­((
4­((
4­((
2­
amino­
4­
hydroxyphenyl)
azo)
phenyl)
amino)­
3­
sulfophenyl)
azo)­
5­
hydroxy­
6­(
phenylazo)­

Structual
Class
 
Sulfonaphthyl­
substituted
N,
N'­
bis(
azophenyl)
urea
salts
3214
 
47
 
9
1,5­
Naphthalenedisulfonic
acid,
3,3'­(
carbonylbis(
imino(
2­
methyl­
4,1­
phenylene)
azo))
bis­,
tetrasodium
salt
28706
 
21
 
0
1,3­
Naphthalenedisulfonic
acid,
7,7'­(
iminobis(
carbonyl(
2­
methyl­
4,1­
phenylene)
azo))
bis­,
tetrasodium
salt
28706
 
22
 
1
1,5­
Naphthalenedisulfonic
acid,
3,3'­(
carbonylbis(
imino(
3­
methoxy­
4,1­
phenylene)
azo))
bis­,
tetrasodium
salt
67969
 
87
 
3
1,3­
Naphthalenedisulfonic
acid,
7­((
4­((((
2­
methoxy­
4­((
3­
sulfophenyl)
azo)
phenyl)
amino)
carbonyl)
amino)­
2­
methylphenyl)
azo)­,
trisodium
salt
71873
 
47
 
7
Benzoic
acid,
3­((
1­
hydroxy­
6­((((
4­((
8­
hydroxy­
3,6­
disulfo­
1­
naphthalenyl)
azo)­
2­
methoxy­
5­
methylphenyl)
amino)
carbonyl)
amino)­
3­
sulfo­
2­
naphthalenyl)
azo)­
4­
methoxy­,
tetrasodium
salt
Structual
Class
 
Tris(
aminoaryl)
methanamimnium
compounds
2390
 
59
 
2
Ethanaminium,
­(
4­(
bis(
4­(
diethylamino)
phenyl)
methylene)­
2,5­
cyclohexadien­
1­
ylidene)­
N­
ethyl­,
chloride
2390
 
60
 
5
Ethanaminium,
­(
4­((
4­(
diethylamino)
phenyl)(
4­(
ethylamino)­
1­
naphthalenyl)
methylene)­
2,5­
cyclohexadien­
1­
ylidene)­
N­
ethyl­,
chloride
2580
 
56
 
5
2­
Methanaminium,
N­(
4­((
4­(
dimethylamino)
phenyl)(
4­
(
phenylamino)­
1­
naphthalenyl)
methylene)­
2,5­
cyclohexadien­
1­
ylidene)­
N­
methyl­,
chloride
1064
 
48
 
8
2,7­
Naphthalenedisulfonic
acid,
4­
amino­
5­
hydroxy­
3­((
4­
nitrophenyl)
azo)­
6­(
phenylazo)­,
disodium
salt
1580
 
44
 
1
2­
Naphthalenesulfonic
acid,
7­
amino­
4­
hydroxy­
3­((
5­
hydroxy­
6­(
phenylazo)­
7­
sulfo­
2­
naphthalenyl)
azo)­,
disodium
salt
6527
 
70
 
4
2,9­
Triphenodioxazinedisulfonic
acid,
6,13­
dichloro­
3,10­
bis(
phenylamino)­,
disodium
salt
1789
 
01
 
9
Cuprate(
2­),
(
mu­((
7,7'­
iminobis(
3­((
5­(
aminosulfonyl)­
2­(
hydroxy­
kappaO)
phenyl)
azo­
kappaN1)­
4­(
hydroxykappaO
2­
naphthalenesulfonato))(
6­)))
di­,
disodium
12239
 
34
 
8
Acetamide,
­(
5­(
bis(
2­(
acetyloxy)
ethyl)
amino)­
2­((
2­
bromo­
4,6­
dinitrophenyl)
azo)­
4­
ethoxyphenyl)­

4232
 
06
 
2
Benzenemethanamine,
N­
ethyl­
N­
4­(
1H­
1,2,4­
triazol­
3­
ylazo)
phenyl
­

41680
 
76
 
6
1,4­
Benzenedicarboxylic
acid,
2,5­
bis(
4­
chlorophenyl)
amino­

18386
 
01
 
7
.
beta.­
Alanine,
N­
ethyl­
N­[
4­[(
5­
nitro­
2,1­
benzisothiazol­
3­
yl)
azo]
phenyl]­,
methyl
ester
58104
 
55
 
5
2­
Naphthalenesulfonamide,
6­
hydroxy­
N­(
2­
hydroxyethyl)­
N­
methyl­
5­((
4­(
phenylazo)
phenyl)
azo)­

64181
 
81
 
3
7­((
4­
Chloro­
6­((
3­
sulfophenyl)
amino)­
1,3,5­
triazin­
2­
yl)
amino)­
4­
hydroxy­
3­((
4­
methoxy­
2­
sulfophenyl)
azo)­
2­
naphthalenesulfonic
acid,
trisodium
salt
67800
 
97
 
9
Chromate(
1­),
bis(
3­(
4­((
5­
chloro­
2­
hydroxyphenyl)
azo)­
4,5­
dihydro­
3­
methyl­
5­
oxo­
1H­
pyrazol­
1­
yl)
benzene
sulfonamidato(
2­)­,
sodium
67905
 
39
 
9
Aluminum,
tris(
triacontyl)­

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No.
146
/
Tuesday,
July
30,
2002
/
Notices
TABLE
4.
 
TWO
HUNDRED
EIGHT
NON­
HPV
DEBITS
CHEMICALS
WITH
PREDICTED
BCFS
OF
3
 
13
 
Continued
CAS
No.
Chemical
name
67907
 
13
 
5
Benzenesulfonic
acid,
2­((
4­((
4­(((
4­
methylphenyl)
sulfonyl)
oxy)
phenyl)
azo)
phenyl)
amino)­
5­
nitro­,
monosodium
salt
68958
 
98
 
5
Benzenesulfonic
acid,
3­((
4­((
4­
hydroxyphenyl)
azo)­
1­
naphthalenyl)
azo)­,
monosodium
salt
70209
 
93
 
7
Benzoic
acid,
2­((
8­((
4­
chloro­
6­((
4­(
6­
methyl­
7­
sulfo­
2­
benzothiazolyl)
phenyl)
amino)­
1,3,5­
triazin­
2­
yl)
amino)­
1­
hydroxy­
3,6­
disulfo­
2­
naphthalenyl)
azo)­,
tetrasodium
salt
70209
 
98
 
2
Benzenesulfonic
acid,
2­((
1­(
2­
chloro­
6­
methylphenyl)­
4,5­
dihydro­
3­
methyl­
5­
oxo­
1H­
pyrazol­
4­
yl)
azo)­
4­((
4­
chloro­
6­(
phenylamino)­
1,3,5­
triazin­
2­
yl)
amino)­,
monosodium
salt
70528
 
90
 
4
3­
Pyridinecarbonitrile,
5­((
4­
chloro­
2­
nitrophenyl)
azo)­
1­
ethyl­
1,2­
dihydro­
6­
hydroxy­
4­
methyl­
2­
oxo­

71735
 
65
 
4
Tetrasodium(
8­
hydroxy­
7­((
2­
hydroxy­
7­
sulpho­
6­((
4­((
2,5,6­
trichloro­
4­
pyrimidinyl)
amino)
phenyl)
azo)­
1­
naphthyl)
azo)
naphthalene­
1,3,6­
trisulphonato(
6­))
cuprate(
4­)

72252
 
58
 
5
Chromate(
4­),
(
mu­(
3­((
2­(
amino­
kappaN)­
5­
(
hydroxy­
kappaO)­
6­((
2­(
hydroxy­
kappaO)­
5­
nitro­
3­
sulfophenyl)
azo­
kappaN1)­
7­
sulfo­
1­
naphthalenyl)
azo­
kappaN1)­
2­
hydroxy­
5­
sulfobenzoato(
8­)))
di­,
tetrasodium
72828
 
69
 
4
Benzenesulfonic
acid,
2­((
5­
amino­
3­
methyl­
1­(
3­
sulfophenyl)­
1H­
pyrazol­
5­
yl)
azo)­,
1,1'­((
1­
methylethylidene)
di­
4,1­
phenylene)
ester,
disodium
salt
73309
 
47
 
4
1­
Naphthalenesulfonic
acid,
4,4'­((
4,6­
dihydroxy­
1,3­
phenylene)
bis(
azo))
bis­,
disodium
salt
78181
 
99
 
4
1­
Propanaminium,
3­((
2­
cyano­
3­(
4­(
diethylamino)
phenyl)­
1­
oxo­
2­
propenyl)
oxy)­
N­(
2­((
2­
cyano­
3­(
4­
(
diethylamino)
phenyl)­
1­
oxo­
2­
propenyl)
oxy)
ethyl)­
N,
N­
dimethyl­,
chloride
85392
 
59
 
2
Iron,
[.
mu.­[
3­[[
5­[[
2,4­
dihydroxy­
5­[(
2­
hydroxy­
3­
nitro­
5­
sulfophenyl)
azo]
phenyl)
phenyl)
methyl­
2,4­
dihydroxyphenyl)
azo)­
2­
hydroxy­
5­
nitrobenzenesulfonato(
6­)))
di­

112484
 
44
 
3
2,7­
Naphthalenedisulfonic
acid,
4­
amino­
6­((
4­(((
4­((
2,4­
diaminophenyl)
azo)
phenyl)
amino)
sulfonyl)
phenyl)
azo)­
5­
hydroxy­
3­((
4­
nitrophenyl)
azo)­,
potassium
sodium
salt
130201
 
55
 
7
Benzenesulfonic
acid,
3,3'­[[
6­(
4­
morpholinyl)­
1,3,5­
triazine­
2,4­
diyl]
bis[
imino[
2­(
acetylamino)­
4,1­
phenylene
azo]]
bis­,
disodium
salt
IV.
Revisions
to
the
TSCA
Section
4(
e)
Priority
Testing
List
A.
Chemicals
Added
to
the
Priority
Testing
List
1.
Benzene,
1,3,5­
tribromo­
2­(
2­
propenyloxy)­
 
i.
Recommendation.
Benzene,
1,3,5­
tribromo­
2­(
2­
propenyloxy)­
(
CAS
No.
3278
 
89
 
5)
is
recommended
to
obtain
unpublished
exposure,
environmental
fate,
health
effects,
and
ecological
effects
data.
ii.
Rationale
for
recommendation.
Benzene,
1,3,5­
tribromo­
2­(
2­
propenyloxy)­
is
predicted
to
persist
and
bioconcentrate.
There
are
very
few
toxicity
data.
Depending
on
the
exposure,
environmental
fate,
health
effects,
and
ecological
effects
data
that
are
provided,
the
EPA
may
consider
benzene,
1,3,5­
tribromo­
2­(
2­
propenyloxy)­
for
their
PBT
Initiative.
iii.
Supporting
information.
Benzene,
1,3,5­
tribromo­
2­(
2­
propenyloxy)­
is
produced
in
excess
of
500,000
pounds
per
annum
and
used
as
a
flame
retardant
for
expanded
polystyrene
insulation
board.
The
predicted
BCF
of
benzene,
1,3,5­
tribromo­
2­(
2­
propenyloxy)­
is
4,019.
The
rat
oral
LD50
was
5
grams/
kilograms
(
g/
kg)
and
it
was
not
mutagenic
in
an
Ames
assay.
A
TOXLINE
search
identified
one
report
that
benzene,
1,3,5­
tribromo­
2­(
2­
propenyloxy)­
was
detected
in
sewer
slime
(
Ref.
13).
iv.
Information
needs.
The
ITC
needs
exposure,
environmental
fate,
health
effects,
and
ecological
effects
data.
Only
studies
where
benzene,
1,3,5­
tribromo­
2­(
2­
propenyloxy)­
is
 
90%
of
the
test
substance
by
weight
should
be
submitted.
2.
1­
Triazene,
1,3­
diphenyl
 
i.
Recommendation.
1­
Triazene,
1,3­
diphenyl
(
diazoaminobenzene)
(
CAS
No.
136
 
35
 
6)
is
being
recommended
to
obtain
annual
production/
importation
volumes
and
trends,
use,
exposure,
and
health
effects
data.
ii.
Rationale
for
recommendation.
No
occupational
exposure
limits
have
been
established
by
the
American
Conference
of
Government
Industrial
Hygienists
(
ACGIH),
the
National
Institute
for
Occupational
Safety
and
Health
(
NIOSH),
or
the
Occupational
Safety
and
Health
Administration
(
OSHA).
Occupational
exposures
have
not
been
characterized
and
there
are
no
estimates
of
the
number
of
workers
exposed.
The
ITC
needs
occupational
exposure
data
from
the
uses
of
diazoaminobenzene,
e.
g.,
to
manufacture
dyes
and
insecticides.
iii.
Supporting
information.
A
recent
National
Toxicology
Program
Report
indicated
that
diazoaminobenzene
is
metabolized
in
rats
and
mice
to
the
known
carcinogens
benzene
and
aniline
(
Ref.
12).
Although
not
tested
for
carcinogenicity,
diazoaminobenzene
is
a
predicted
carcinogen
based
on
its
metabolism
and
similarity
in
toxic
effects
to
benzene
and
aniline.
Diazoaminobenzene
is
used
as
an
intermediate,
complexing
agent,
and
polymer
additive.
It
is
an
impurity
in
certain
color
additives
used
in
cosmetics,
food
products,
and
pharmaceuticals.
It
may
also
be
used
as
a
propellant
for
molding
of
rubbers
and
plastics
and
as
a
coupler
to
promote
adhesion
of
natural
rubber
to
steel
tire
cords.
Since
diazoaminobenzene
has
semiconducting
properties
it
may
have
applications
in
the
semi
conductor
industry.
Diazoaminobenzene
may
put
workers
at
a
heretofore
unrecognized
increased
risk
of
cancer
if
they
are
exposed
in
the
workplace.
Importation,
production,
use,
and
exposure
information
will
assist
in
determining
if
diazoaminobenzene
may
need
further
testing
to
adequately
assess
potential
hazards
associated
with
occupational
exposures.
iv.
Information
needs.
 
a.
Recent
non­
CBI
estimates
of
annual
production
or
importation
volume
data
and
trends.
b.
Use
information,
including
percentages
of
production
or
importation
that
are
associated
with
different
uses.
c.
Estimates
of
the
number
of
humans
and
concentrations
of
diazoaminobenzene
compounds
to
which
humans
may
be
exposed
from
use,
manufacturing,
or
processing.
d.
Health
effects
data
including
pharmacokinetics,
genotoxicity,
subchronic
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Notices
and
chronic
toxicity,
reproductive,
and
developmental
toxicity,
and
any
human
data
from
occupationally
exposed
workers.
This
information
is
needed
in
order
to
adequately
access
the
extent
and
degree
of
exposure
and
potential
hazard
associated
with
diazoaminobenzene.
e.
Only
studies
where
diazoaminobenzene
is
 
90%
of
the
test
substance
by
weight
should
be
submitted.

B.
Chemicals
Removed
From
the
Priority
Testing
List
1.
Acetone.
Acetone
was
designated
in
the
ITC's
28th
ITC
Report
for
reproductive
effects
testing
as
a
chemical
with
a
low
confidence
reference
dose
or
RfD
(
56
FR
41212,
August
19,
1991)
(
FRL
 
3937
 
4).
Acetone
is
being
removed
from
the
Priority
Testing
List
because
it
was
in
the
OECD
SIDS
program
(
see
http://
irptc.
unep.
ch/
irptc/
sids/
sidspub.
html
volume
6)
and
because
it
is
included
in
the
EPA's
VCCEP
for
reproductive
effects
and
developmental
toxicity
testing
(
http://
www.
epa.
gov/
chemrtk/
childhlt.
htm).
The
EPA
anticipates
that
under
the
VCCEP,
tier
2
testing
for
prenatal
developmental
toxicity,
reproductive
and
fertility
effects
testing
will
be
conducted
for
acetone.
2.
Twenty
alkylphenols
and
alkylphenol
ethoxylates.
The
ITC
is
continuing
to
review
data
on
the
alkylphenols
and
alkylphenol
ethoxylates
that
were
recommended
in
ITC's
37th
ITC
Report
(
61
FR
4188,
February
2,
1996)
(
FRL
 
4991
 
6),
39th
ITC
Report
(
62
FR
8578,
February
25,
1997)
(
FRL
 
5580
 
9),
and
41st
ITC
Report
(
63
FR
17658
,
April
9,
1998)
(
FRL
 
5773
 
5).
At
this
time,
the
ITC
is
removing
from
the
Priority
Testing
List,
9
alkylphenols
and
alkylphenol
ethoxylates
from
the
37th
ITC
Report,
7
nonylphenol
ethoxylates
from
the
39th
ITC
Report,
and
4
alkylphenols
and
alkylphenol
ethoxylates
from
the
41st
ITC
Report
(
see
Table
5
of
this
appendix).
The
rationales
for
removing
these
alkylphenols
and
alkylphenol
ethoxylates
are
provided
as
footnotes
to
Table
5
of
this
appendix.

TABLE
5.
 
ALKYLPHENOLS
AND
ALKYLPHENOL
ETHOXYLATES
BEING
REMOVED
FROM
THE
PRIORITY
TESTING
LIST
Report
CAS
No.
Chemical
name
Rationale
37
99
 
71
 
8
4­
sec­
Butylphenol
1
37
104
 
40
 
5
4­
Nonylphenol
2
37
1638
 
22
 
8
4­
n­
Butylphenol
2
37
9002
 
93
 
1
Polyethylene
glycol
4­(
tert­
octyl)
phenyl
ether
2
37
9036
 
19
 
5
Polyethylene
glycol
mono(
octyl)
phenyl
ether
3
37
14938
 
35
 
3
4­
Pentylphenol
2
37
27193
 
28
 
8
(
1,1,3,3­
Tetramethylbutyl)
phenol
(
mixed
isomers)
3
37
27193
 
86
 
8
Dodecylphenol
(
mixed
isomers)
4
37
68987
 
90
 
6
Poly(
oxy­
1,2­
ethanediyl),
.
alpha.­(
octylphenyl)­.
omega.­
hydroxy­,
branched
3
39
20427
 
84
 
3
2­[
2­(
4­
Nonylphenoxy)
ethoxy]
ethanol
2
39
37205
 
87
 
1
Poly(
oxy­
1,2­
ethanediyl),
.
alpha.­(
isononylphenyl)­.
omega.­
hydroxy­
2
39
68412
 
54
 
4
Poly(
oxy­
1,2­
ethanediyl),
.
alpha.­(
nonylphenyl)­.
omega.­
hydroxy­,
branched
2
39
98113
 
10
 
1
NP
9
2
39
127087
 
87
 
0
Poly(
oxy­
1,2­
ethanediyl),
.
alpha.­(
4­
nonylphenyl)­.
omega.­
hydroxy­,
branched
2
39
9016
 
45
 
9
Poly(
oxy­
1,2­
ethanediyl),
.
alpha.­(
nonylphenyl)­.
omega.­
hydroxy­
5
39
26027
 
38
 
3
Poly(
oxy­
1,2­
ethanediyl),
.
alpha.­(
4­
nonylphenyl)­.
omega.­
hydroxy­
5
41
74499
 
35
 
7
Phenol,
(
tetrapropenyl)
derivs.
4
41
68908
 
55
 
4
Phenol,
polybutene
derivs.
2
41
112375
 
88
 
9
Phenol,
polyisobutylene
derivs.
2
41
9014
 
92
 
0
Poly(
oxy­
1,2­
ethanediyl),
a­(
dodecylphenyl)­
 ­
hydroxy­
2
Removal
rationales:
1.
Data
developed
from
testing
4­
tert­
butylphenol
(
CAS
No.
98
 
54
 
4)
in
response
to
the
HPV
Challenge
program
may
be
used
to
predict
toxicity
2.
No
domestic
production
or
importation
volumes
were
reported
to
the
EPA
in
response
to
1986,
1990,
1994,
and
1998
IURs
or
no
domestic
production
or
importation
volumes
were
reported
to
the
EPA
in
response
to
the
July
5,
2000
PAIR
rule
(
65
FR
41371)
(
FRL
 
6589
 
1).
3.
Data
developed
from
testing
phenol,
4­(
1,1,3,3­
tetramethylbutyl)­
(
CAS
No.
140
 
66
 
9)
in
response
to
the
HPV
Challenge
program
may
be
used
to
predict
toxicity.
4.
Data
developed
from
testing
p­
dodecylphenol
(
CAS
No.
210555
 
94
 
5)
in
response
to
the
HPV
Challenge
program
may
be
used
to
predict
toxicity.
5.
Data
developed
from
testing
branched
nonylphenol
(
CAS
No.
84852
 
15
 
3)
in
response
to
the
HPV
Challenge
program
may
be
used
to
predict
toxicity.

There
are
10
alkylphenols
and
alkylphenol
ethoxylates
remaining
on
the
Priority
Testing
List
(
see
Table
6
of
this
appendix).

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/
Notices
TABLE
6.
 
ALKYLPHENOLS
AND
ALKYLPHENOL
ETHOXYLATES
REMAINING
ON
THE
PRIORITY
TESTING
LIST
Report
CAS
No.
Chemical
name
37
80
 
46
 
6
4­
tert­
Pentylphenol
37
88
 
18
 
6
2­
tert­
Butylphenol
37
98
 
54
 
4
4­
tert­
Butylphenol
37
1806
 
26
 
4
4­
Octylphenol
37
25154
 
52
 
3
Nonylphenol
(
mixed
isomers)

37
84852
 
15
 
3
Branched
nonylphenol
(
mixed
isomers)

39
27986
 
36
 
3
2­(
Nonylphenoxyl)
ethanol
41
1987
 
50
 
4
Phenol,
4­
heptyl­

41
72624
 
02
 
3
Phenol,
heptyl
derivs.

41
140
 
66
 
9
Phenol,
4­(
1,1,3,3­
tetramethylbutyl)­

3.
Three
DEBITS
chemicals
from
the
46th
ITC
Report.
In
its
46th
ITC
Report,
the
ITC
discussed
2
groups
of
DEBITS
chemicals,
polychlorophenols
and
polychlorobenzenethiols
and
chlorotrifluoromethylphenoxy
benzenes
(
65
FR
75552,
December
1,
2000)
(
FRL
 
6594
 
7).
Two
of
the
polychlorophenols
and
polychlorobenzenethiols
(
pentachlorothiophenol,
CAS
No.
133
 
49
 
3
and
tetrachloropyrocatechol,
CAS
No.
1198
 
55
 
6)
and
two
of
the
chlorotrifluoromethylphenoxy
benzenes
(
ptoluidine
5­
chloro­.
alpha.,.
alpha.,.
alpha.­
trifluoro­
2­
nitro­
N­
phenyl,
CAS
No.
1806
 
24
 
2
and
benzoic
acid,
3­[
2­
chloro­
4­
(
trifluoromethyl)
phenoxy]­,
2­
ethoxy­
1­
methyl­
2­
oxo,
CAS
No.
88185
 
22
 
2)
were
subsequently
added
to
the
Priority
Testing
List
in
the
ITC's
47th
ITC
Report.
All
4
of
these
chemicals
were
added
to
the
July
26,
2001
PAIR
rule
(
66
FR
38955)
(
FRL
 
6783
 
6).
All
of
these
chemicals,
except
pentachlorothiophenol,
are
being
removed
from
the
Priority
Testing
List
because
no
production
or
importation
data
were
submitted
to
the
EPA
in
response
to
the
1998
IUR
(
10,000
pound
reporting
threshold)
or
the
July
26,
2001
PAIR
rule
(
1,000
pound
reporting
threshold).
4.
Three
DEBITS
chemicals
from
the
47th
ITC
Report.
In
its
47th
ITC
Report,
the
ITC
added
3
chloroalkenes
to
the
Priority
Testing
List:
1,3­
butadiene,
1,1,2,3,4­
pentachloro­
4­
(
1­
methylethoxy)­
(
CAS
No.
68334
 
67
 
8);
3­
butenoic
acid,
2,2,3,4,4­
pentachloro­
butyl
ester
(
CAS
No.
75147
 
20
 
9);
and
3­
butenoic
acid,
2,2,3,4,4­
pentachloro­
(
CAS
No.
85743
 
61
 
9).
The
ITC
is
removing
these
3
chloroalkenes
from
the
Priority
Testing
List
because
no
production
or
importation
data
were
submitted
to
the
EPA
in
response
to
the
1998
IUR.
5.
Nine
DEBITS
chemicals
from
the
48th
ITC
Report.
In
its
48th
ITC
Report,
the
ITC
added
5
chlorinated
trihalomethyl
pyridines,
2
trihaloethylidene
bisbenzenes,
4
trichlorophenyldihydropyrazols
and
3­
chloro­
2,6­
dinitro­
N,
N­
dipropyl­
4­
(
trifluoromethyl)
­
benzeneamine
to
the
Priority
Testing
List.
The
ITC
is
removing
the
5
chlorinated
trihalomethyl
pyridines,
1
of
the
trihaloethylidene
bisbenzenes
(
benzene,
1,1'­(
2,2,2­
trichloroethylidene)
bis­),
and
3
of
the
trichlorophenyldihydropyrazols
(
benzamide,
3­
amino­
N­[
4,5­
dihydro­
5­
oxo­
1­
(
2,4,6­
trichlorophenyl)­
1H­
pyrazol­
3­
yl;
3Hpyrazol
3­
one,
5­((
5­
amino­
2­
chlorophenyl)
amino)
­
2,4­
dihydro­
2­(
2,4,6­
trichlorophenyl)­;
and
benzamide,
N­(
4,5­
dihydro­
5­
oxo­
1­
(
2,4,6­
trichlorophenyl)­
1Hpyrazol
3­
yl)­
3­
nitro­)
from
the
Priority
Testing
List
because
no
production
or
importation
data
were
submitted
to
the
EPA
in
response
to
the
1998
IUR
or
because
the
predicted
BCFs
were
judged
to
be
too
low
to
warrant
priority
consideration
at
this
time.

V.
References
1.
ITC.
1977.
Initial
Report
of
the
TSCA
Interagency
Testing
Committee
(
October
1,
1977)
to
the
Administrator;
Receipt
of
Report
and
Request
for
Comments
Regarding
the
Priority
Testing
List
of
Chemicals.
Federal
Register
(
42
FR
55026
 
55080,
October
12,
1977).
2.
ITC.
1978a.
Second
Report
of
the
TSCA
Interagency
Testing
Committee
(
April
10,
1978)
to
the
Administrator;
Receipt
of
Report
and
Request
for
Comments
Regarding
the
Priority
Testing
List
of
Chemicals.
Federal
Register
(
43
FR
16684
 
16688,
April
19,
1978).
3.
ITC.
1978b.
Third
Report
of
the
TSCA
Interagency
Testing
Committee
(
October
2,
1978)
to
the
Administrator;
Receipt
of
Report
and
Request
for
Comments
Regarding
the
Priority
Testing
List
of
Chemicals.
Federal
Register
(
43
FR
50630
 
50635,
October
10,
1978).
4.
ITC.
1979.
Fifth
Report
of
the
TSCA
Interagency
Testing
Committee
(
November
8,
1979)
to
the
Administrator;
Receipt
of
Report
and
Request
for
Comments
Regarding
the
Priority
Testing
List
of
Chemicals.
Federal
Register
(
44
FR
70664
 
70674,
December
7,
1979).
5.
ITC.
1980a.
Sixth
Report
of
the
TSCA
Interagency
Testing
Committee
(
April
9,
1980)
to
the
Administrator;
Receipt
of
Report
and
Request
for
Comments
Regarding
the
Priority
Testing
List
of
Chemicals.
Federal
Register
(
45
FR
35897
 
35910,
May
28,
1980).
6.
ITC.
1980b.
Seventh
Report
of
the
TSCA
Interagency
Testing
Committee
(
October
24,
1980)
to
the
Administrator;
Receipt
of
Report
and
Request
for
Comments
Regarding
the
Priority
Testing
List
of
Chemicals.
Federal
Register
(
45
FR
78432
 
78446,
November
25,
1980).
7.
ITC.
1982.
Eleventh
Report
of
the
TSCA
Interagency
Testing
Committee
(
November
3,
1982)
to
the
Administrator;
Receipt
of
Report
and
Request
for
Comments
Regarding
Priority
Testing
List
of
Chemicals.
Federal
Register
(
47
FR
54625
 
54644,
December
3,
1982).
8.
ITC.
1984.
Fourteenth
Report
of
the
TSCA
Interagency
Testing
Committee
(
May
8,
1984)
to
the
Administrator;
Receipt
of
Report
and
Request
for
Comments
Regarding
Priority
Testing
List
of
Chemicals.
Federal
Register
(
49
FR
22389
 
22407,
May
29,
1984).
9.
ITC.
1985.
Sixteenth
Report
of
the
TSCA
Interagency
Testing
committee
(
May
2,
1985)
to
the
Administrator;
Receipt
of
Report
and
Request
for
Comments
Regarding
Priority
Testing
List
of
Chemicals.
Federal
Register
(
50
FR
20930
 
20939,
May
21,
1985).
10.
ITC.
1986.
Nineteenth
Report
of
the
TSCA
Interagency
Testing
Committee
(
October
31,
1986)
to
the
Administrator;
Receipt
of
Report
and
Request
for
Comments
Regarding
Priority
Testing
List
of
Chemicals.
Federal
Register
(
51
FR
41417
 
41432,
November
14,
1986).
11.
ITC.
1989.
Twenty­
fifth
Report
of
the
TSCA
Interagency
Testing
Committee
(
November
1,
1989)
to
the
Administrator;
Receipt
of
Report
and
Request
for
Comments
Regarding
Priority
Testing
List
of
Chemicals.
Federal
Register
(
54
FR
51114
 
51130,
December
12,
1989).
12.
National
Toxicology
Program
(
NTP).
2002.
Toxicity
Report
Series
Number
73.
NTP
report
on
the
metabolism,
toxicity,
and
predicted
carcinogenicity
of
diazoaminobenzene
(
CAS
No.
136
 
35
 
6),
U.
S.
Department
of
Health
and
Human
Services,
Public
Health
Service,
National
Institutes
of
Health.
NIH
Publication
No.
01
 
4412.
Draft
abstract
available
online
at:
http:/

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49547
Federal
Register
/
Vol.
67,
No.
146
/
Tuesday,
July
30,
2002
/
Notices
/
ntp­
server.
niehs.
nih.
gov/
htdocs/
ST­
studies/
tox073.
html
13.
Sauer
J.,
Antusch
E.,
and
Ripp
C.
1997.
Monitoring
of
organic
pollutants
in
sewer
systems
by
sewer
slime
analysis.
pp.
49
 
69.
In
Haberer
K
(
ed.)
Water.
VCH
Publishers,
Inc.,
New
York,
NY.
ISBN
3
 
527
 
28820
 
1.
14.
Walker
JD.
1993.
The
TSCA
Interagency
Testing
Committee,
1977
to
1992:
Creation,
structure,
functions
and
contributions.
pp.
451
 
509.
In
J.
W.
Gorsuch,
F.
J.
Dwyer,
C.
G.
Ingersoll
and
T.
W.
La
Pointe
(
eds.),
Environmental
Toxicology
and
Risk
Assessment:
Second
Volume,
ASTM
STP
1216.
ASTM,
Philadelphia,
PA.

VI.
TSCA
Interagency
Testing
Committee
Statutory
Organizations
and
Their
Representatives
Council
on
Environmental
Quality
Vacant
Department
of
Commerce
National
Institute
of
Standards
and
Technology
Robert
Huie,
Member
Barbara
C.
Levin,
Alternate
National
Oceanographic
and
Atmospheric
Administration
Thomas
P.
O'Connor,
Member
Teri
Rowles,
Alternate
Environmental
Protection
Agency
Paul
Campanella,
Member
David
R.
Williams,
Alternate
National
Cancer
Institute
Alan
Poland,
Member
David
Longfellow,
Alternate
National
Institute
of
Environmental
Health
Sciences
Scott
Masten,
Member,
Chair
William
Eastin,
Alternate
National
Institute
for
Occupational
Safety
and
Health
Mark
Toraason,
Member,
Vice
Chair
Dennis
W.
Lynch,
Alternate
National
Science
Foundation
A.
Frederick
Thompson,
Member
Marge
Cavanaugh,
Alternate
Occupational
Safety
and
Health
Administration
Val
H.
Schaeffer,
Member
Lyn
Penniman,
Alternate
Liaison
Organizations
and
Their
Representatives
Agency
for
Toxic
Substances
and
Disease
Registry
William
Cibulas,
Member
Daphne
Moffett,
Alternate
Consumer
Product
Safety
Commission
Jacqueline
Ferrante,
Member
Treye
Thomas,
Alternate
Department
of
Agriculture
Clifford
P.
Rice,
Member
Laurau
L.
McConnell,
Alternate
Department
of
Defense
Barbara
Larcom,
Member
Kenneth
Still,
Alternate
Jose
´
Centeno,
Alternate
Department
of
the
Interior
Barnett
A.
Rattner,
Member
Food
and
Drug
Administration
David
Hatten,
Alternate
National
Library
of
Medicine
Vera
W.
Hudson,
Member
National
Toxicology
Program
NIEHS,
FDA,
and
NIOSH
Members
Counsel
Scott
Sherlock,
OPPT,
EPA
Technical
Support
Contractor
Syracuse
Research
Corporation
ITC
Staff
John
D.
Walker,
Executive
Director
Norma
S.
L.
Williams,
Executive
Assistant
TSCA
Interagency
Testing
Committee,
Office
of
Pollution
Prevention
and
Toxics
(
7401M),
Environmental
Protection
Agency,
1200
Pennsylvania
Ave.,
NW.,
Washington,
DC
20460;
telephone
number:
(
202)
564
 
7527;
fax
number:
(
202)
564
 
7528;
e­
mail
address:
williams.
norma@
epa.
gov;
url:
http://
www.
epa.
gov/
opptintr/
itc.

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