May
13,
2003
1
National
Advisory
Council
for
Environmental
Policy
and
Technology
(
NACEPT)
Endocrine
Disruptor
Methods
Validation
Subcommittee
(
EDMVS)
Plenary
Meeting
June
5­
6,
2003
Proposed
Agenda
RESOLVE
1255
23rd
Street,
N.
W.,
Suite
275
Washington,
DC
20037
(
202)
944­
2300
Meeting
Objectives:


Review
and
discuss
the
status/
results
of
the
prevalidation
work
on
the
aromatase
assay,
steroidogenesis
assay,
the
one
generation
extension
study,
and
the
mammalian
two
generation
assay;
and

Provide
input
and
advice
on
the
EDSP's
validation
plans
for
the
steroidogenesis
assay
and
mammalian
two
generation
assay.

Thursday,
June
5,
2003
9:
00
 
9:
10
Welcome
and
Opening
Comments
Joe
Merenda,
EDMVS
Chair
and
Director,
Office
of
Science
Coordination
and
Policy
(
OSCP),
EPA
9:
10
 
9:
30
Introduction,
Agenda
Review,
and
Review
of
Previous
Meeting
Summary
Paul
De
Morgan,
Facilitator,
RESOLVE
9:
30
 
10:
00
Review
of
EDMVS
Work
Plan
Jane
Smith,
EDMVS
Designated
Federal
Official
(
DFO),
OSCP,
EPA
10:
00
 
10:
15
Review
of
EDMVS
Member
Selection
Process
Jane
Smith,
EDMVS
DFO,
OSCP,
EPA
10:
15
 
10:
30
Break
10:
30
 
11:
30
Presentation
on
Status
of
Aromatase
Assay
(
Tier
I):
Optimization
and
Performance
Comparison
of
the
Assay
Using
Placental
Tissues
(
Porcine,
Human,
Bovine)
and
Human
Recombinant
Receptor
Jim
Matthews,
Ph.
D.,
Research
Triangle
Institute
(
RTI)

11:
30
 
12:
30
Update
of
OECD
EDTA
Activities
Gary
Timm
and
Les
Touart,
Ph.
D.,
OSCP,
EPA
12:
30
 
1:
45
Lunch
May
13,
2003
2
1:
45
 
2:
30
Presentation
and
Discussion
of
Steroidogenesis
Assay
(
Tier
I):
Preliminary
Results
of
the
Optimization
of
the
Protocol
using
Sliced
Testes
Carol
Sloan,
Ph.
D.,
RTI
2:
30
 
3:
15
Presentation
and
Discussion
of
EDSP's
Prevalidation
and
Validation
Plans
for
Steroidogenesis
Gary
Timm,
OSCP,
EPA
3:
15
 
3:
30
Break
3:
30
 
4:
30
Discussion
of
Steroidogenesis
Plans
and
Related
Issues
4:
30
 
5:
00
Public
Comment
Members
of
the
public
will
be
given
an
opportunity
to
comment
on
any
aspect
of
the
EDMVS
work.
The
amount
of
time
given
to
each
individual
will
depend
on
the
number
of
people
wishing
to
provide
comment.

5:
00
Adjourn
Friday,
June
6,
2003
8:
30
 
8:
45
Settling
In
8:
45
 
10:
30
Study
Results,
Comments,
and
Discussion
of
One
Generation
Extension
Julia
George,
Ph.
D.,
RTI
Paul
Foster,
Ph.
D.,
National
Institute
of
Environmental
Health
Sciences
(
NIEHS)

10:
30
 
10:
45
Break
10:
45
 
12:
00
Presentation
and
Discussion
of
EDSP
Validation
Plan
for
the
Mammalian
Two
Generation
Assay
Jim
Kariya,
OSCP,
EPA
12:
00
 
1:
15
Lunch
1:
15
 
2:
30
Continued
Discussion
of
EDSP
Validation
Plan
for
Mammalian
Two
Generation
Assay
2:
30
 
3:
00
Next
Steps
and
Agenda
for
August
Meeting
3:
00
Adjourn
