TESTING
PBPK
TESTING
PBPK
PBPK
*
interim
APPENDIX
A.
Proposed
Schedule
for
Toxicity
Testing
and
TIER
CATEGORY
DESCRIPTION
3
TESTING
COMBINED
ACUTE
INHALATION
TOXICITY
AND
ACUTE
INHALATION
NEUROTOXICITY
TESTING
PKIMECH
DATA
FOR
F344
RATS
TESTING
PBPK
MODELING
SIMULATIONS
EPA
DECISION
ON
PK
ACCEPTABILITY
SUBCHRONIC
ORAL
NEUROTOXICITY
ROUTE
TO
ROUTE
REPRODUCTIVE
ORAL
TOXICITY
ROUTE
TO
ROUTE
SUBCHRONIC
ROUTE
TO
ROUTE
reports
marked
by
arrows
PBPK
Modeling
Activities
for
ethylene
dichloride*

MONTHS
AFTER
SIGNING
OF
ECA
6
9
12
18
21
24
TESTING
COMPLETED/
FINAL
REPORT
4
4
TESTING
COMPLETED
FINAL
REPORT
4
MODEL
FINAL
REPORT
4
2
30
36
42
52
TESTING
COMPLETED
FINAL
REPORT
4
FINAL
REPORT
TESTING
COMPLETED
FINAL
REPORT
4
FINAL
REPORT
4
FINAL
REPORT
4
RECEIVED
OPPT
NCIC
2003
MAR11
5:
03PM
OPPT­
2003­
0010­
0044
