APPENDIX
A
FLOW
CHART
OF
TESTING
PROGRAM
OPPT­
2003­
0010­
0005
RECEIVED
OPPT
NCIC
2003
MAR11
4:
57PM
APPENDIX
A.
Proposed
Schedule
for
Toxicity
Testing
and
PBPK
Modeling
Activities
for
ethylene
dichloride*

TIER
CATEGORY
DESCRIPTION
MONTHS
AFTER
SIGNING
OF
ECA
3
6
9
12
18
21
24
TESTING
COMBINED
ACUTE
INHALATION
TESTING
COMPLETED/
FINAL
REPORT
TOXICITY
AND
ACUTE
INHALATION
4
NEUROTOXICITY
4
TESTING
PKIMECH
DATA
FOR
F344
RATS
TESTING
COMPLETED
FINAL
REPORT
4
TESTING
PBPK
MODELING
SIMULATIONS
MODEL
FINAL
REPORT
4
EPA
DECISION
ON
PK
ACCEPTABILITY
2
TESTING
SUBCHRONIC
ORAL
NEUROTOXICITY
PBPK
ROUTE
TO
ROUTE
TESTING
REPRODUCTIVE
ORAL
TOXICITY
PBPK
ROUTE
TO
ROUTE
PBPK
SUBCHRONIC
ROUTE
TO
ROUTE
*
interim
reports
marked
by
arrows
30
36
42
52
TESTING
COMPLETED
FINAL
REPORT
4
FINAL
REPORT
TESTING
COMPLETED
FINAL
REPORT
4
FINAL
REPORT
4
FINAL
REPORT
