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May
2001
PBT
Profiler
Fact
Sheet
Modified
from:
http://
www.
epa.
gov/
opptintr/
pbt/
toolbox.
htm
EPA
has
developed
a
PBT
Profiler.
The
PBT
Profiler
is
a
subset
of
methods
included
in
the
P2
Framework
which
is
an
approach
to
risk
screening
that
incorporates
pollution
prevention
principles
in
the
design
and
development
of
chemicals.
The
objective
of
the
P2
Framework
approach
is
to
inform
decision
making
at
early
stages
of
development
and
promote
the
selection
and
application
of
safer
chemicals
and
processes.
This
approach
is
implemented
by
means
of
a
subset
of
estimation
methods
included
in
OPPT's
P2
Framework.
The
P2
Framework
project
description
and
manual
are
available
at:
http://
www.
epa.
gov/
opptintr/
p2framework
How
does
the
PBT
Profiler
work?
EPA
has
taken
methods
for
estimating
environmental
persistence
(P),
bioconcentration
potential
(B),
and
aquatic
toxicity
(T)
and
integrated
these
into
a
PBT
Profiler.
The
PBT
Profiler
will
predict
P,
B,
and
T
characteristics
from
chemical
structure.
When
the
user
accesses
the
PBT
Profiler
on
the
Internet,
the
program
prompts
the
user
to
enter
the
Chemical
Abstract
Service
(CAS)
number
of
chemicals
under
consideration.
The
PBT
Profiler
is
linked
a
database
containing
CAS
numbers
and
associated
chemical
structure
for
over
100,000
discrete
chemical
substances.
If
the
CAS
number
is
in
the
database,
the
PBT
Profiler
will
translate
the
CAS
number
into
a
chemical
structure,
predict
the
PBT
characteristics,
and
provide
a
PBT
Profile
in
a
easy
to
understand
format.
A
drawing
program
is
available
so
that
the
user
can
draw
and
enter
the
structure
if
the
CAS
number
is
not
in
the
database.
The
structure
can
also
be
entered
as
a
SMILES
Notation.

In
addition,
the
PBT
Profiler
compares
the
results
of
a
profile
with
the
PBT
criteria
established
for
Premanufacture
Notices
(PMNs)
submitted
under
section
5
of
TSCA;
and
the
final
rule
for
reporting
chemicals
under
the
Toxic
Chemical
Release
Inventory
(TRI),
under
section
313
of
the
Emergency
Planning
and
Community
Right­
toKnow
Act
(EPCRA).
A
sample
model
run
from
the
PBT
Profiler
of
a
known
PBT
chemical
(CAS
56­
55­
3)
is
shown
printed
in
the
color
version.
A
Black
&
White
version
is
also
available.

Status
of
the
PBT
Profiler:
EPA
has
initiated
a
formal
scientific
peer
review
of
the
revised,
updated,
PBT
Profiler.
This
peer
review
is
being
conducted
under
EPA's
Peer
Review
Policy
and
in
accordance
with
the
Agency's
peer
review
procedures.
The
PBT
Profiler
will
be
publicly
available
when
the
peer
review
is
completed,
and
the
PBT
Profiler
is
revised
to
reflect
peer
review
comments
received.

The
PBT
Profiler
was
beta
tested
by
industry
and
other
stakeholders
to
further
evaluate
the
technical
accuracy
of
the
PBT
Profiler
and
to
solicit
comments
on
the
format,
content,
and
interpretation
of
results
of
the
PBT
Profiler.
Based
on
the
results
of
the
beta
test,
the
Agency
made
revisions
to
the
PBT
Profiler.
Several
beta
testers
are
currently
helping
develop
Case
Studies
screening
chemicals
using
the
PBT
Profiler.

EPA
does
not
rely
solely
on
results
of
screening
level
methods,
such
as
the
PBT
Profiler,
to
regulate
chemicals!
Users
should
remember
that
this
is
a
screening
level
method
that
provides
estimates
of
PBT
characteristics,
and
is
useful
for
establishing
priorities
for
chemical
evaluation
when
chemical­
specific
data
are
lacking.
This,
and
any
screening
level
method,
should
be
used
with
caution!
If
the
PBT
Profiler
identifies
an
issue
of
potential
concern,
additional
data
should
be
gathered
and/
or
additional
analyses
conducted
to
come
to
an
informed
decision
about
the
chemicals
under
review.

There
are
limitations
associated
with
the
PBT
Profiler.
These
limitations
are
highlighted
and
explained
for
the
user
within
the
model
itself.
For
information
on
the
PBT
Profiler,
please
contact:
Bill
Waugh,
Program
Manager,
ph:
202­
260­
3489
fax:
202­
260­
1216
waugh.
bill@
epa.
gov
Maggie
Wilson,
Technical
Lead,
ph:
202­
260­
3902
fax:
202­
260­
1216
wilson.
maggie@
epa.
gov
