                   DRAFT AGENDA
FEDERAL INSECTICIDE, FUNGICIDE, AND RODENTICIDE ACT (FIFRA)
SCIENTIFIC ADVISORY PANEL (SAP)
                      PUBLIC VIRTUAL PEER REVIEW MEETING
                              SEPTEMBER 15, 2020
                                       
                  FIFRA SAP WEB SITE: https://www.epa.gov/sap
                DOCKET ID NUMBER: EPA - HQ - OPP - 2020 - 0263
                                       
                     MEETING LOCATION: Phone and Webcast 
   For Video Link and Audio Registration (to Receive call-in number) go to:
                            https://www.epa.gov/sap
                                        
          [Please note that all times are approximate as noted at the
     end of the Agenda. Agency speakers may change based on availability.]
                                       
        Title:  U.S. Environmental Protection Agency Peer Review for: 
 The Use of New Approach Methodologies (NAMs) to Derive Extrapolation Factors and Evaluate Developmental Neurotoxicity for Human Health Risk Assessment
                                        
                                         Day 1
                             Tuesday, September 15, 2020
                                        Day 1
                             Tuesday, September 15, 2020

                    10:00 A.M. 	Opening of Meeting  -  Tamue L. Gibson, MS, Designated Federal Official, EPA, Office of Chemical Safety and Pollution Prevention (OCSPP), Office of Science Coordination and Policy (OSCP)  

  10:10 A.M. 		Introduction and Identification of Panel Members  -  Robert E. Chapin, 
            PhD, FIFRA SAP Chair

 10:20 A.M.	Welcome  -  Alexandra Dapolito Dunn, Esq, Assistant Administrator, EPA/OCSPP

 10:25 A.M.	Greetings and Introduction from the Office Director and Division Director -  Edward Messina, Acting Office Director, EPA, Office of Pesticide Programs (OPP); Dana Vogel, Division Director, EPA, OPP, Health Effects Division (HED)

  10:30 A.M. 	OPP Technical Presentation  - Introduction and Overview of the Regulatory Use of the New Approach Methodologies (NAMs)  -  Monique Perron, PhD, EPA, OPP, HED  

  11:15 A.M.		BREAK

  11:30 A.M.		FIFRA SAP Discussion on OPP Technical Presentation

  12:30 P.M.		LUNCH BREAK



    1:15 P.M.		Development of NAMs to Evaluate Developmental Neurotoxicity  -  
            EPA, Office of  Research Development (ORD)
            
    3:00 P.M.		BREAK

    3:15 P.M.		FIFRA SAP Discussion on ORD Technical Presentation

    4:00 P.M.		Use of in vitro Acetylcholinesterase Inhibition Data to Develop 
                  Data-Derived Extrapolation Factor's - EPA, Office of Pesticide Programs 

    5:00 P.M.		FIFRA SAP Discussion on ORD Technical Presentation

    5:30 P.M.	Adjourn






































                                        Day 2 
                             Tuesday, September 16, 2020
                                       Day 2 
                             Tuesday, September 16, 2020

                    10:00 A.M. 	Opening of Meeting  -  Tamue L. Gibson, MS, Designated Federal Official, EPA, OCSPP, OSCP

 10:05 A.M. 	Panel Members: Follow-up from the Previous Day  -  Robert E. Chapin, PhD, FIFRA SAP Chair

  10:15 A.M.	Public Comments 

  12:00 P.M. 		LUNCH BREAK

    1:00 P.M.		Charge Question 1: NAMs for Development Neurotoxicity

    2:30 P.M.		BREAK

    2:45 P.M.		Charge Question 2: NAMs for Development Neurotoxicity

    4:00 P.M.	Charge Question 3: NAMs for Development Neurotoxicity

    5:30 P.M.	ADJOURN




























                                       Day 3 
                            Thursday, September 17, 2020
                                       Day 3 
                            Thursday, September 17, 2020

                  10:00 A.M. 	Opening of Meeting  -  Tamue L. Gibson, MS, Designated Federal Official, EPA, OCSPP, OSCP

10:05 A.M. 	Panel Members: Follow-up from the Previous Day  -  Robert E. Chapin, PhD, FIFRA SAP Chair

10:20 A.M. 		Charge Question 4: NAMs for Development Neurotoxicity

11:30 A.M.		Charge Question 5: Data-derived Extrapolation Factor's Using In
            Vitro AChE Inhibition Data

12:30 P.M.		LUNCH BREAK

  1:15 P.M.		Charge Question 6: Data-derived Extrapolation Factor's Using In
            Vitro AChE Inhibition Data

  3:00 P.M.		BREAK

  3:15 P.M.		Charge Question 7: Data-derived Extrapolation Factor's Using In
            Vitro AChE Inhibition Data

  5:30 P.M.	            Adjourn



























                                       Day 4 
                             Friday, September 18, 2020
                                       Day 4 
                             Friday, September 18, 2020

                     10:00 A.M. 	Opening of Meeting  -  Tamue L. Gibson, MS, Designated Federal Official, EPA, OCSPP, OSCP

  10:05 A.M. 		Panel Members: Follow-up from the Previous Day  -  Robert E. Chapin, 
            PhD, FIFRA SAP Chair

  10:20 A.M. 		Charge Question 8: Data-derived Extrapolation Factor's Using In
            Vitro AChE Inhibition Data

  11:30 A.M. 		BREAK

                  11:45  A.M.	Closing Remarks  -  Robert E. Chapin, PhD, FIFRA SAP Chair & Other Panel Members

  12:00 P.M.		Adjourn 


Please be advised that agenda times are approximate; when the discussion for one topic is completed, discussions for the next topic will begin. For further information, please contact the Designated Federal Official for this meeting, Tamue Gibson, M.S., via email: gibson.tamue@epa.gov.
