UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C.  20460

Office of Chemical Safety and Pollution Prevention

MEMORANDUM			

July 1, 2015								

SUBJECT:	Cyprodinil – Acute and Chronic Dietary and Drinking Water
Exposure and Risk Assessment For The Expansions of Existing Crop
Group/Representative Commodity Uses to Stone Fruit Group 12-12, and
Adding New Uses on the Artichoke, Guava, Pomegranate, Passionfruit,
Feijoa, Jaboticaba, Wax Jambu, Starfruit, and Acerola and Amended Uses
on Greenhouse Cucumbers and Small Tomatoes.  

PC Code:  288202	DP Barcode: D425997

Decision No.:  490951	Registration No.: 100-811, 100-1317, 100-828, &
100-953

Petition No.:  4e8273	Regulatory Action:  Section 3 

Risk Assessment Type:  Dietary	Case No.:  NA

TXR No.:  NA	CAS No: 121552-61-2

MRID No.:  NA	40 CFR:  180.532



FROM:	Thurston G. Morton, Chemist

Risk Assessment Branch IV

Health Effects Division (7509P)

THROUGH:	Pete Savoia, Chemist 

		Meheret Negussie, Chemist

		Dietary Exposure Science Advisory Council (DESAC),

		and

		Charles Smith, Acting Branch Chief

Health Effects Division (7509P)

TO:		Laura Nollen/Barbara Madden

Risk Integration, Minor Use & Emergency Response Branch                 
  Registration Division (RD) (7505P)

This document provides an acute and chronic dietary and drinking water
risk analyses of exposures resulting from use of cyprodinil as a
fungicide on food crops.  This assessment supports requests for the
expansion of existing crop group fruit, stone, group 12-12, and adding
new uses on the globe artichoke, guava, pomegranate, passionfruit,
feijoa, jaboticaba, wax jambu, starfruit, and acerola and amended uses
on greenhouse cucumbers and small tomatoes.

Executive Summary

Acute and chronic dietary risk assessments were conducted for cyprodinil
using the Dietary Exposure Evaluation Model (DEEM-FCID, Version 3.18),
which incorporates consumption data from USDA’s National Health and
Nutrition Examination Survey, What We Eat in America, (NHANES/WWEIA). 
This dietary survey was conducted from 2003 to 2008.

   

Acute Dietary Exposure Analysis Results and Characterization

A conservative acute dietary exposure analysis was performed for the
general U.S. population and various population subgroups.  Tolerance
level residues and 100 % crop treated assumptions were used.  DEEM
default and empirical processing factors were used to modify the
tolerance values.  The acute analysis incorporated the 1 in 10 year peak
surface drinking water estimate from application of cyprodinil to
grapes.    SEQ CHAPTER \h \r 1 The resulting 95th percentile acute
exposure estimates are not of concern for the general U.S. population or
any of the other population subgroups.  The subgroup with the highest
risk estimate is children 1-2 years old with a % acute population
adjusted dose (aPAD) of 8.6%.  The % aPAD for the general U.S.
population is 4.8%.     

Chronic Dietary Exposure Analysis Results and Characterization

A partially refined chronic dietary exposure analysis was performed for
the general U.S. population and various population subgroups.  For the
chronic dietary analysis, tolerance level residues for most commodities;
average field trial residues for pome fruit, head lettuce, leaf lettuce,
spinach, tomato, and grapes; and 100% crop treated assumptions were
used.  DEEM default and empirical processing factors were used to modify
the tolerance values.  The chronic analysis incorporated the 10 year
average surface drinking water estimate from application of cyprodinil
to grapes.  Chronic dietary risk estimates are not of concern for the
general U.S. population or any of the other population subgroups.  The
subgroup with the highest risk estimate is children 1-2 years old with a
% chronic PAD (cPAD) of 85%.  The % cPAD for the general U.S. population
is 29%. 

I.	Introduction

Dietary risk assessment incorporates both exposure and toxicity of a
given pesticide.  For acute and chronic assessments, the risk is
expressed as a percentage of a maximum acceptable dose (i.e., the dose
which HED has concluded will result in no unreasonable adverse health
effects).  This dose is referred to as the PAD.  The PAD is equivalent
to the point of departure (POD, NOAEL, LOAEL, etc) divided by the
required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when
estimated dietary risk exceeds 100% of the PAD.  References that discuss
the acute and chronic risk assessments in more detail are available on
the EPA/pesticides web site:  “Available Information on Assessing
Exposure from Pesticides, A User’s Guide,” 6/21/2000, web link:   
HYPERLINK
"http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf" 
http://www.epa.gov/fedrgstr/EPA_PEST/2000/July/Day_12/6061.pdf  ; or see
SOP 99.6 (8/20/99).

The most recent dietary risk assessment for cyprodinil was conducted by
T. Morton (3-May-2012; DP#390233).

II.	Residue Information

Residues of Concern 

The metabolism of cyprodinil has been studied in apple, peach, potato,
tomato, and wheat.  The residue of concern in plants is the parent
compound cyprodinil as determined by the HED Metabolism Assessment
Review Committee (MARC) (D243198, G. Kramer, 3/11/98).  The nature of
the residue in ruminants is adequately understood based on acceptable
lactating goat metabolism studies.  HED has concluded that the residues
of concern for both risk assessment and the tolerance definition should
include the combined residues of cyprodinil and free and conjugated
CGA-304075, expressed in parent equivalents (D345970 and D345182, G.
Kramer, 6/4/08).  The water residues of concern as determined by MARC
are the parent and CGA 249287 (4-cyclopropyl-6-methylpyrimidin-2-amine)
(D292557, 6/8/03).  HED continues to consider these metabolites and
degradates to be the residues of concern.

Table 1:  Summary of Residues of Concern for Cyprodinil 

Matrix	Residues of Concern

	For Risk Assessment	For Tolerance Expression

Plants	cyprodinil	cyprodinil

Livestock	cyprodinil and CGA-304075	cyprodinil and CGA-304075

Water	cyprodinil and CGA 249287	NA



Established/Recommended Tolerances

Permanent tolerances are established (40 CFR §180.532(a)) for residues
of cyprodinil per se in/on a variety of crop commodities, at levels
ranging from 0.02 ppm in/on almonds to 340 ppm in citrus oil. 
Recommended tolerances for the proposed amended/new uses are as follows
(D421157, T. Morton, 04/23/2015).  

Artichoke…..	4.0 ppm

Guava	1.5 ppm

Passionfruit………………..………………….………………
…………….1.5 ppm

Feijoa………………..………………….……………………
….………….1.5 ppm
Jaboticaba………………..……………………………….…
…………..….1.5 ppm 

Wax
Jambu………………..……………………………….………
……….1.5 ppm

Starfruit 	1.5 ppm

Acerola	1.5 ppm

Pomegranate	7.0 ppm

Fruit, stone, group 12-12……………...	2.0 ppm

HED continues to recommend that the current tolerance expression for
animal commodities be changed to reflect both parent and metabolite
CGA-304075 (4-[(4-cyclopropyl-6-methyl-2-2-pyrimidinyl)amino]-phenol).

Residues Used in the Acute and Chronic Analysis

For the acute dietary analysis, tolerance level residues and 100% crop
treated assumptions were used for all treated commodities.  For the
chronic dietary analysis, tolerance level residues for most commodities;
average field trial residues for pome fruit, head lettuce, leaf lettuce,
spinach, tomato, and grapes; and 100% crop treated assumptions were
used.  Default processing factors were used for most processed
commodities, except for tomato paste/puree in the chronic(1x) and
lemon/lime juice (1x).  Residues used in the acute and chronic dietary
analysis are provided in Table 2.  Average residues where noted were
used in the chronic dietary analysis.

Table 2. Residue Estimates Used in the Cyprodinil Acute and Chronic
Dietary/Drinking Water Analysis

Commodity	Tolerance (ppm)

Crop Subgroup 1B, except sugarbeet	0.75

Crop Group 2 	10

Onion, bulb subgroup 3-07A	0.6

Onion, green subgroup 3-07B	4.0

Crop Subgroup 4A 	50 tolerance/0.87 avg head lettuce

50 tolerance/13 avg leaf lettuce

50 tolerance/11.8 avg spinach

Crop Subgroup 4B	30

Crop Subgroup 5A Head and stem 	1.0

Crop Subgroup 5B Leafy Brassica greens 	10

Bean, dry; Bean, succulent	0.6

Vegetable, fruiting, group 8-10	1.5

Crop Group 9	0.7

Lemon, Lime	0.6

Citrus Oil	60

Pome fruit, Crop group 11-10 (B. Cropp-Kohlligian, D378920, 10/27/10)
1.7 tolerance/0.50 avg apple

1.7 tolerance/0.38 avg pear

Stone fruit, Crop group 12	2

Caneberry, subgroup 13-07A	10

Bushberry subgroup 13-07B	3

Small fruit vine climbing subgroup 13-07F, except fuzzy kiwifruit (G.
Kramer, D247620, 6/14/02)	3.0 tolerance/0.81 avg grapes

Low growing berry subgroup 13-07G, except cranberry	5.0 (inc.
strawberry)

Almond	0.02

Pistachio	0.1

Crop Subgroup 19A Herb Fresh (except parsley)               	3

Crop Subgroup 19A Herb Dried (except parsley)               	15

Parsley, dried leaves            	170

Parsley leaves	35

Rape seed oil (canola, seed)	0.03

Avocado,  Canistel; Mango; Papaya; Sapodilla; Sapote, black; Sapote,
mamey; Star apple	1.2

Dragonfruit	2.0

Kiwifruit	1.8

Watercress	20

Beef, Goat, Horse, Sheep, meat byproducts (including liver and kidney )
0.02

Grape, raisin	5.0

Turnip, greens	10.0



III.	Percent Crop Treated Information

The acute and chronic dietary exposure analyses assumed 100% crop
treated (CT).  

IV.	Drinking Water Data

WC in surface water is 34.8 μg/L for the total residues of cyprodinil
plus CGA-249287.  The chronic EDWC in surface waters is 24.7 μg/L for
the total residues of cyprodinil and CGA-249287.  The cancer/chronic
EDWC in surface waters is 16.4 μg/L for the total residues of
cyprodinil and CGA-249287.  All surface waters EDWCs were obtained using
the New York grapes PRZM scenario.  The PRZM-GW generated EDWC for the
use on grapes, using the FL citrus surrogate scenario were 2.05 μg/L
for the total residues of cyprodinil and CGA-249287 (acute) and 1.80
μg/L for the total residues (chronic).  For details on methods,
characterization of results, uncertainties, etc., please, refer to the
previous DWAs. Table 3 provides a summary of the Tier 2 modeled drinking
water concentrations.

Table 3.  Maximum Estimated Drinking Water Concentrations for the Use of
Cyprodinil (expressed as total residues of cyprodinil plus its degradate
CGA-249287)

DRINKING WATER SOURCE (MODEL USED) 	USE (rate modeled per year)	MAXIMUM
ESTIMATED DRINKING WATER CONCENTRATION  (EDWC)  ( ppb) 

Groundwater (PRZM-GW)	FL citrus1 (1.4 lb a.i.)	Acute	2.05



Chronic	1.80

Surface water

(PRZM/EXAMS)	NY grapes (1.4 lb a.i.)	Acute	34.8



Chronic	24.7



Cancer/Chronic	16.4

1 Scenario was used as a surrogate and run with the maximum application
rate for grapes.

V.	DEEM-FCID Program and Consumption Information

Cyprodinil acute and chronic dietary exposure assessments were conducted
using the Dietary Exposure Evaluation Model software with the Food
Commodity Intake Database DEEM-FCID, Version 3.18, which incorporates
consumption data from USDA’s National Health and Nutrition Examination
Survey, What We Eat in America, (NHANES/WWEIA).  This dietary survey was
conducted from 2003 to 2008.  The data are based on the reported
consumption of more than 20,000 individuals over two non-consecutive
survey days.  Foods “as consumed” (e.g., apple pie) are linked to
EPA-defined food commodities (e.g. apples, peeled fruit - cooked; fresh
or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using
publicly available recipe translation files developed jointly by
USDA/ARS and EPA.  For chronic exposure assessment, consumption data are
averaged for the entire U.S. population and within population subgroups,
but for acute exposure assessment are retained as individual consumption
events.  Based on analysis of the 2003-2008 WWEIA consumption data,
which took into account dietary patterns and survey respondents, HED
concluded that it is most appropriate to report risk for the following
population subgroups: the general U.S. population, all infants (<1 year
old), children 1-2, children 3-5, children 6-12, youth 13-19, adults
20-49, females 13-49, and adults 50-99 years old.

For chronic dietary exposure assessment, an estimate of the residue
level in each food or food-form (e.g., orange or orange juice) on the
food commodity residue list is multiplied by the average daily
consumption estimate for that food/food form.  The resulting residue
consumption estimate for each food/food form is summed with the residue
consumption estimates for all other food/food forms on the commodity
residue list to arrive at the total average estimated exposure. 
Exposure is expressed in mg/kg body weight/day and as a percent of the
cPAD.  This procedure is performed for each population subgroup.

For acute exposure assessments, individual one-day food consumption data
are used on an individual-by-individual basis.  The reported consumption
amounts of each food item can be multiplied by a residue point estimate
and summed to obtain a total daily pesticide exposure for a
deterministic exposure assessment, or “matched” in multiple random
pairings with residue values and then summed in a probabilistic
assessment.  The resulting distribution of exposures is expressed as a
percentage of the aPAD on both a user (i.e., those who reported eating
relevant commodities/food forms) and a per-capita (i.e., those who
reported eating the relevant commodities as well as those who did not)
basis.  In accordance with HED policy, per capita exposure and risk are
reported for all tiers of analysis.  However, for Tiers 1 and 2,
significant differences in user vs. per capita exposure and risk are
identified and noted in the risk assessment.

VI.	Toxicological Information

HED evaluated the toxicology data base for cyprodinil and selected doses
and endpoints for  chronic dietary and drinking water risk assessments
provided in Table 4.  

Table 4. Summary of Toxicological Doses and Endpoints for Cyprodinil 
for Use in Dietary Human Health Risk Assessments

Exposure/Scenario	Point of Departure	Uncertainty/FQPA Safety Factors
RfD, PAD, LOC for Risk Assessment	Study and Toxicological Effects





Acute Dietary

(All Populations)	

NOAEL = 200 mg/kg/day	

UFA= 10x

UFH=10x

FQPA SF= 1x	

Acute RfD = 2.0 mg/kg/day           aPAD = 2.0 mg/kg/day    

	Acute Neurotoxicity - Rat

LOAEL = 600 mg/kg/day based on clinical signs of toxicity, low motor
activity and reversible hypothermia

Chronic Dietary 

(All Populations)	NOAEL= 2.7 mg/kg/day	UFA = 10x

UFH =10x

FQPA SF= 1x	Chronic RfD = 0.027

mg/kg/day

cPAD = 0.027mg/kg/day	2-Year Chronic Toxicity/ Carcinogenicity- rat

LOAEL = 35.6 mg/kg/day based on degenerative liver lesions (spongiosis
hepatis) in males.

Cancer (all routes)	Classification: “Not likely to be carcinogenic to
humans”

Point of Departure (POD) = A data point or an estimated point that is
derived from observed dose-response data and  used to mark the beginning
of extrapolation to determine risk associated with lower environmentally
relevant human exposures.  

NOAEL = no observed adverse effect level.  

LOAEL = lowest observed adverse effect level.  

UF = uncertainty factor.  

UFA = extrapolation from animal to human (interspecies).  

UFH = potential variation in sensitivity among members of the human
population (intraspecies).  

FQPA SF = FQPA Safety Factor.  

PAD = population adjusted dose (a = acute, c = chronic).  

RfD = reference dose.  

VII.	Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned
when dietary risk exceeds 100% of the PAD.  The DEEM-FCID™ analyses
estimate the dietary exposure of the U.S. population and various
population subgroups.  The results reported in Tables 5 & 6 are for the
general U.S. Population, all infants (<1 year old), children 1-2,
children 3-5, children 6-12, youth 13-19, females 13-49, adults 20-49,
and adults 50-99 years.

Results of Acute Dietary Exposure Analysis

The results of the acute dietary exposure analysis are reported in Table
5.  

Table 5:  Summary of Acute Dietary Exposure and Risk for Cyprodinil

Population Subgroup	aPAD (mg/kg/day)	Acute (95th Percentile)



Exposure (mg/kg/day)	%aPAD

General U.S. Population	2.0	0.095198	4.8

All Infants (< 1 year old)

0.101588	5.1

Children 1-2 years old

0.172629	8.6

Children 3-5 years old

0.158663	7.9

Children 6-12 years old

0.083374	4.2

Youth 13-19 years old

0.071553	3.6

Adults 20-49 years old

0.091866	4.6

Adults 50+ years old

0.091595	4.6

Females 13-49 years old

0.096706	4.8

The bolded %aPAD is the highest.

Results of Chronic Dietary Exposure Analysis

The results of the chronic dietary exposure analysis are reported in
Table 6.  

Table 6:  Summary of Chronic Dietary Exposure and Risk for Cyprodinil

Population Subgroup	cPAD (mg/kg/day)	Chronic



Exposure (mg/kg/day)	% cPAD

General U.S. Population	0.027	0.007794	29

All Infants (< 1 year old)

0.013042	48

Children 1-2 years old

0.023045	85

Children 3-5 years old

0.016592	62

Children 6-12 years old

0.008522	32

Youth 13-19 years old

0.004665	17

Adults 20-49 years old

0.006327	23

Adults 50+ years old

0.007772	29

Females 13-49 years old

0.006706	25

The bolded %cPAD is the highest.

VIII.	Characterization of Inputs/Outputs

For the acute dietary analysis, tolerance level residues and 100% crop
treated assumptions were used for all treated commodities.  For the
chronic dietary analysis, tolerance level residues for most commodities;
average field trial residues for pome fruit, head lettuce, leaf lettuce,
spinach, tomatoes, lemon, and grapes; and 100% crop treated assumptions
were used.  Default processing factors were used for all processed
commodities except tomato paste/puree (1x) and lemon/lime juice (1x). 
Risk drivers are celery, pome fruit, and strawberry.  Residues do not
warrant further refinement at this time.

IX.	Conclusions

An acute and chronic dietary exposure analyses was performed for the
general U.S. population and various population subgroups.  The acute and
chronic risk estimates are below HED’s level of concern.  HED is
confident the acute and chronic dietary exposures to cyprodinil are not
underestimated.

X.  List of Attachments

1.  Acute DEEM-FCID Residue Input File.

2.  Results of Acute DEEM-FCID Dietary Exposure Analysis.

3.  Chronic DEEM-FCID Residue Input File.

4.  Results of Chronic DEEM-FCID Dietary Exposure Analysis.

Attachment 1 Acute DEEM-FCID Residue Input File

Filename: C:\Users\tmorton\Documents\My Files\DEEM Files\288202
Cyprodinil\Cyprodinil 4E8273\288202ACUTEEPARECOMMENDATIONS PLUS 13-07F
CODEX HARM.R08

Chemical: cyprodinil

RfD(Chronic): .03 mg/kg bw/day  NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): 2 mg/kg bw/day  NOEL(Acute):  0 mg/kg bw/day

Date created/last modified: 04-09-2015/09:37:24       Program ver. 3.16,
03-08-d

------------------------------------------------------------------------
-----------

   EPA     Crop                                   Def Res    
Adj.Factors   Comment

   Code     Grp  Commodity Name                    (ppm)       #1    #2 
 

---------- ---- -------------------------------  ----------  ------
------  -------

0101050000 1AB  Beet, garden, roots                0.750000   1.000 
1.000  

0101050001 1AB  Beet, garden, roots-babyfood       0.750000   1.000 
1.000  

0101067000 1AB  Burdock                            0.750000   1.000 
1.000  

0101078000 1AB  Carrot                             0.750000   1.000 
1.000  

0101078001 1AB  Carrot-babyfood                    0.750000   1.000 
1.000  

0101079000 1AB  Carrot, juice                      0.750000   1.000 
1.000  

0101084000 1AB  Celeriac                           0.750000   1.000 
1.000  

0101100000 1AB  Chicory, roots                     0.750000   1.000 
1.000  

0101168000 1AB  Ginseng, dried                     0.750000   1.000 
1.000  

0101190000 1AB  Horseradish                        0.750000   1.000 
1.000  

0101250000 1AB  Parsley, turnip rooted             0.750000   1.000 
1.000  

0101251000 1AB  Parsnip                            0.750000   1.000 
1.000  

0101251001 1AB  Parsnip-babyfood                   0.750000   1.000 
1.000  

0101314000 1AB  Radish, roots                      0.750000   1.000 
1.000  

0101316000 1AB  Radish, Oriental, roots            0.750000   1.000 
1.000  

0101327000 1AB  Rutabaga                           0.750000   1.000 
1.000  

0101331000 1AB  Salsify, roots                     0.750000   1.000 
1.000  

0101388000 1AB  Turnip, roots                      0.750000   1.000 
1.000  

0200051000 2    Beet, garden, tops                10.000000   1.000 
1.000  

0200101000 2    Chicory, tops                     10.000000   1.000 
1.000  

0200140000 2    Dasheen, leaves                   10.000000   1.000 
1.000  

0200315000 2    Radish, tops                      10.000000   1.000 
1.000  

0200317000 2    Radish, Oriental, tops            10.000000   1.000 
1.000  

0200332000 2    Salsify, tops                     10.000000   1.000 
1.000  

0301165000 3A   Garlic, bulb                       0.600000   1.000 
1.000  

0301165001 3A   Garlic, bulb-babyfood              0.600000   1.000 
1.000  

0301237000 3A   Onion, bulb                        0.600000   1.000 
1.000  

0301237001 3A   Onion, bulb-babyfood               0.600000   1.000 
1.000  

0301238000 3A   Onion, bulb, dried                 0.600000   9.000 
1.000  

0301238001 3A   Onion, bulb, dried-babyfood        0.600000   9.000 
1.000  

0301338000 3A   Shallot, bulb                      0.600000   1.000 
1.000  

0302103000 3B   Chive, fresh leaves                3.000000   1.000 
1.000  

0302198000 3B   Leek                               4.000000   1.000 
1.000  

0302239000 3B   Onion, green                       4.000000   1.000 
1.000  

0302338500 3B   Shallot, fresh leaves              4.000000   1.000 
1.000  

0401005000 4A   Amaranth, leafy                   50.000000   1.000 
1.000  

0401018000 4A   Arugula                           50.000000   1.000 
1.000  

0401104000 4A   Chrysanthemum, garland            50.000000   1.000 
1.000  

0401133000 4A   Cress, garden                     50.000000   1.000 
1.000  

0401134000 4A   Cress, upland                     50.000000   1.000 
1.000  

0401138000 4A   Dandelion, leaves                 50.000000   1.000 
1.000  

0401150000 4A   Endive                            50.000000   1.000 
1.000  

0401204000 4A   Lettuce, head                     50.000000   1.000 
1.000  

0401205000 4A   Lettuce, leaf                     50.000000   1.000 
1.000  

0401248000 4A   Parsley, leaves                   50.000000   1.000 
1.000  

0401313000 4A   Radicchio                         50.000000   1.000 
1.000  

0401355000 4A   Spinach                           50.000000   1.000 
1.000  

0401355001 4A   Spinach-babyfood                  50.000000   1.000 
1.000  

0402076000 4B   Cardoon                           30.000000   1.000 
1.000  

0402085000 4B   Celery                            30.000000   1.000 
1.000  

0402085001 4B   Celery-babyfood                   30.000000   1.000 
1.000  

0402086000 4B   Celery, juice                     30.000000   1.000 
1.000  

0402087000 4B   Celtuce                           30.000000   1.000 
1.000  

0402152000 4B   Fennel, Florence                  30.000000   1.000 
1.000  

0402322000 4B   Rhubarb                           30.000000   1.000 
1.000  

0402367000 4B   Swiss chard                       30.000000   1.000 
1.000  

0501061000 5A   Broccoli                           1.000000   1.000 
1.000  

0501061001 5A   Broccoli-babyfood                  1.000000   1.000 
1.000  

0501062000 5A   Broccoli, Chinese                  1.000000   1.000 
1.000  

0501064000 5A   Brussels sprouts                   1.000000   1.000 
1.000  

0501069000 5A   Cabbage                            1.000000   1.000 
1.000  

0501071000 5A   Cabbage, Chinese, napa             1.000000   1.000 
1.000  

0501072000 5A   Cabbage, Chinese, mustard          1.000000   1.000 
1.000  

0501083000 5A   Cauliflower                        1.000000   1.000 
1.000  

0501196000 5A   Kohlrabi                           1.000000   1.000 
1.000  

0502063000 5B   Broccoli raab                     10.000000   1.000 
1.000  

0502070000 5B   Cabbage, Chinese, bok choy        10.000000   1.000 
1.000  

0502117000 5B   Collards                          10.000000   1.000 
1.000  

0502194000 5B   Kale                              10.000000   1.000 
1.000  

0502229000 5B   Mustard greens                    10.000000   1.000 
1.000  

0502318000 5B   Rape greens                       10.000000   1.000 
1.000  

0502389000 5B   Turnip, greens                    10.000000   1.000 
1.000  

0602031000 6B   Bean, broad, succulent             0.600000   1.000 
1.000  

0602033000 6B   Bean, cowpea, succulent            0.600000   1.000 
1.000  

0602037000 6B   Bean, lima, succulent              0.600000   1.000 
1.000  

0603030000 6C   Bean, black, seed                  0.600000   1.000 
1.000  

0603032000 6C   Bean, broad, seed                  0.600000   1.000 
1.000  

0603034000 6C   Bean, cowpea, seed                 0.600000   1.000 
1.000  

0603035000 6C   Bean,  great northern, seed        0.600000   1.000 
1.000  

0603036000 6C   Bean, kidney, seed                 0.600000   1.000 
1.000  

0603038000 6C   Bean, lima, seed                   0.600000   1.000 
1.000  

0603039000 6C   Bean, mung, seed                   0.600000   1.000 
1.000  

0603040000 6C   Bean, navy, seed                   0.600000   1.000 
1.000  

0603041000 6C   Bean, pink, seed                   0.600000   1.000 
1.000  

0603042000 6C   Bean, pinto, seed                  0.600000   1.000 
1.000  

0603098000 6C   Chickpea, seed                     0.600000   1.000 
1.000  

0603098001 6C   Chickpea, seed-babyfood            0.600000   1.000 
1.000  

0603099000 6C   Chickpea, flour                    0.600000   1.000 
1.000  

0603182000 6C   Guar, seed                         0.600000   1.000 
1.000  

0603182001 6C   Guar, seed-babyfood                0.600000   1.000 
1.000  

0603203000 6C   Lentil, seed                       0.600000   1.000 
1.000  

0801374000 8A   Tomatillo                          1.500000   1.000 
1.000  

0801375000 8A   Tomato                             1.500000   1.000 
1.000  

0801375001 8A   Tomato-babyfood                    1.500000   1.000 
1.000  

0801376000 8A   Tomato, paste                      1.500000   1.000 
1.000  

0801376001 8A   Tomato, paste-babyfood             1.500000   1.000 
1.000  

0801377000 8A   Tomato, puree                      1.500000   1.000 
1.000  

0801377001 8A   Tomato, puree-babyfood             1.500000   1.000 
1.000  

0801378000 8A   Tomato, dried                      1.500000  14.300 
1.000  

0801378001 8A   Tomato, dried-babyfood             1.500000  14.300 
1.000  

0801379000 8A   Tomato, juice                      1.500000   1.000 
1.000  

0801380000 8A   Tomato, Tree                       1.500000   1.000 
1.000  

0802148000 8BC  Eggplant                           1.500000   1.000 
1.000  

0802234000 8BC  Okra                               1.500000   1.000 
1.000  

0802270000 8B   Pepper, bell                       1.500000   1.000 
1.000  

0802270001 8B   Pepper, bell-babyfood              1.500000   1.000 
1.000  

0802271000 8B   Pepper, bell, dried                1.500000   1.000 
1.000  

0802271001 8B   Pepper, bell, dried-babyfood       1.500000   1.000 
1.000  

0802272000 8BC  Pepper, nonbell                    1.500000   1.000 
1.000  

0802272001 8BC  Pepper, nonbell-babyfood           1.500000   1.000 
1.000  

0802273000 8BC  Pepper, nonbell, dried             1.500000   1.000 
1.000  

0901075000 9A   Cantaloupe                         0.700000   1.000 
1.000  

0901187000 9A   Honeydew melon                     0.700000   1.000 
1.000  

0901399000 9A   Watermelon                         0.700000   1.000 
1.000  

0901400000 9A   Watermelon, juice                  0.700000   1.000 
1.000  

0902021000 9B   Balsam pear                        0.700000   1.000 
1.000  

0902088000 9B   Chayote, fruit                     0.700000   1.000 
1.000  

0902102000 9B   Chinese waxgourd                   0.700000   1.000 
1.000  

0902135000 9B   Cucumber                           0.700000   1.000 
1.000  

0902308000 9B   Pumpkin                            0.700000   1.000 
1.000  

0902309000 9B   Pumpkin, seed                      0.700000   1.000 
1.000  

0902356000 9B   Squash, summer                     0.700000   1.000 
1.000  

0902356001 9B   Squash, summer-babyfood            0.700000   1.000 
1.000  

0902357000 9B   Squash, winter                     0.700000   1.000 
1.000  

0902357001 9B   Squash, winter-babyfood            0.700000   1.000 
1.000  

1001108000 10A  Citrus, oil                       60.000000   1.000 
1.000  

1002199000 10B  Lemon                              0.600000   1.000 
1.000  

1002200000 10B  Lemon, juice                       0.600000   1.000 
1.000  

1002200001 10B  Lemon, juice-babyfood              0.600000   1.000 
1.000  

1002201000 10B  Lemon, peel                        0.600000   1.000 
1.000  

1002206000 10B  Lime                               0.600000   1.000 
1.000  

1002207000 10B  Lime, juice                        0.600000   1.000 
1.000  

1002207001 10B  Lime, juice-babyfood               0.600000   1.000 
1.000  

1100007000 11   Apple, fruit with peel             1.700000   1.000 
1.000  PP#0F7

            Full comment: PP#0F7696

1100008000 11   Apple, peeled fruit                1.700000   1.000 
1.000  PP#0F7

            Full comment: PP#0F7696

1100008001 11   Apple, peeled fruit-babyfood       1.700000   1.000 
1.000  PP#0F7

            Full comment: PP#0F7696

1100009000 11   Apple, dried                       1.700000   8.000 
1.000  PP#0F7

            Full comment: PP#0F7696

1100009001 11   Apple, dried-babyfood              1.700000   8.000 
1.000  PP#0F7

            Full comment: PP#0F7696

1100010000 11   Apple, juice                       1.700000   1.300 
1.000  PP#0F7

            Full comment: PP#0F7696

1100010001 11   Apple, juice-babyfood              1.700000   1.300 
1.000  PP#0F7

            Full comment: PP#0F7696

1100011000 11   Apple, sauce                       1.700000   1.000 
1.000  PP#0F7

            Full comment: PP#0F7696

1100011001 11   Apple, sauce-babyfood              1.700000   1.000 
1.000  PP#0F7

            Full comment: PP#0F7696

1100129000 11   Crabapple                          1.700000   1.000 
1.000  PP#0F7

            Full comment: PP#0F7696

1100173500 11   Goji berry                         1.500000   1.000 
1.000  

1100210000 11   Loquat                             1.700000   1.000 
1.000  PP#0F7

            Full comment: PP#0F7696

1100266000 11   Pear                               1.700000   1.000 
1.000  PP#0F7

            Full comment: PP#0F7696

1100266001 11   Pear-babyfood                      1.700000   1.000 
1.000  PP#0F7

            Full comment: PP#0F7696

1100267000 11   Pear, dried                        1.700000   6.250 
1.000  PP#0F7

            Full comment: PP#0F7696

1100268000 11   Pear, juice                        1.700000   1.000 
1.000  PP#0F7

            Full comment: PP#0F7696

1100268001 11   Pear, juice-babyfood               1.700000   1.000 
1.000  PP#0F7

            Full comment: PP#0F7696

1100310000 11   Quince                             1.700000   1.000 
1.000  PP#0F7

            Full comment: PP#0F7696

1201090000 12A  Cherry                             2.000000   1.000 
1.000  

1201090001 12A  Cherry-babyfood                    2.000000   1.000 
1.000  

1201091000 12A  Cherry, juice                      2.000000   1.500 
1.000  

1201091001 12A  Cherry, juice-babyfood             2.000000   1.500 
1.000  

1202012000 12B  Apricot                            2.000000   1.000 
1.000  

1202012001 12B  Apricot-babyfood                   2.000000   1.000 
1.000  

1202013000 12B  Apricot, dried                     2.000000   6.000 
1.000  

1202014000 12B  Apricot, juice                     2.000000   1.000 
1.000  

1202014001 12B  Apricot, juice-babyfood            2.000000   1.000 
1.000  

1202230000 12B  Nectarine                          2.000000   1.000 
1.000  

1202260000 12B  Peach                              2.000000   1.000 
1.000  

1202260001 12B  Peach-babyfood                     2.000000   1.000 
1.000  

1202261000 12B  Peach, dried                       2.000000   7.000 
1.000  

1202261001 12B  Peach, dried-babyfood              2.000000   7.000 
1.000  

1202262000 12B  Peach, juice                       2.000000   1.000 
1.000  

1202262001 12B  Peach, juice-babyfood              2.000000   1.000 
1.000  

1203285000 12C  Plum                               2.000000   1.000 
1.000  

1203285001 12C  Plum-babyfood                      2.000000   1.000 
1.000  

1203286000 12C  Plum, prune, fresh                 2.000000   1.000 
1.000  

1203286001 12C  Plum, prune, fresh-babyfood        2.000000   1.000 
1.000  

1203287000 12C  Plum, prune, dried                 2.000000   5.000 
1.000  

1203287001 12C  Plum, prune, dried-babyfood        2.000000   5.000 
1.000  

1203288000 12C  Plum, prune, juice                 2.000000   1.400 
1.000  

1203288001 12C  Plum, prune, juice-babyfood        2.000000   1.400 
1.000  

1301055000 13A  Blackberry                        10.000000   1.000 
1.000  

1301056000 13A  Blackberry, juice                 10.000000   1.000 
1.000  

1301056001 13A  Blackberry, juice-babyfood        10.000000   1.000 
1.000  

1301058000 13A  Boysenberry                       10.000000   1.000 
1.000  

1301208000 13A  Loganberry                        10.000000   1.000 
1.000  

1301320000 13A  Raspberry                         10.000000   1.000 
1.000  

1301320001 13A  Raspberry-babyfood                10.000000   1.000 
1.000  

1301321000 13A  Raspberry, juice                  10.000000   1.000 
1.000  

1301321001 13A  Raspberry, juice-babyfood         10.000000   1.000 
1.000  

1302057000 13B  Blueberry                          3.000000   1.000 
1.000  

1302057001 13B  Blueberry-babyfood                 3.000000   1.000 
1.000  

1302136000 13B  Currant                            3.000000   1.000 
1.000  

1302137000 13B  Currant, dried                     3.000000   1.000 
1.000  

1302149000 13B  Elderberry                         3.000000   1.000 
1.000  

1302174000 13B  Gooseberry                         3.000000   1.000 
1.000  

1302191000 13B  Huckleberry                        3.000000   1.000 
1.000  

1304175000 13D  Grape                              3.000000   1.000 
1.000  

1304176000 13D  Grape, juice                       3.000000   1.200 
1.000  

1304176001 13D  Grape, juice-babyfood              3.000000   1.200 
1.000  

1304179000 13D  Grape, wine and sherry             3.000000   1.000 
1.000  

1304195000 13D  Kiwifruit, fuzzy                   1.800000   1.000 
1.000  

1307359000 13G  Strawberry                         5.000000   1.000 
1.000  

1307359001 13G  Strawberry-babyfood                5.000000   1.000 
1.000  

1307360000 13G  Strawberry, juice                  5.000000   1.000 
1.000  

1307360001 13G  Strawberry, juice-babyfood         5.000000   1.000 
1.000  

1400003000 14   Almond                             0.020000   1.000 
1.000  

1400003001 14   Almond-babyfood                    0.020000   1.000 
1.000  

1400004000 14   Almond, oil                        0.020000   1.000 
1.000  

1400004001 14   Almond, oil-babyfood               0.020000   1.000 
1.000  

1400282000 14   Pistachio                          0.100000   1.000 
1.000  

1901028000 19A  Basil, fresh leaves                3.000000   1.000 
1.000  

1901028001 19A  Basil, fresh leaves-babyfood       3.000000   1.000 
1.000  

1901029000 19A  Basil, dried leaves               15.000000   1.000 
1.000  

1901029001 19A  Basil, dried leaves-babyfood      15.000000   1.000 
1.000  

1901102500 19A  Chive, dried leaves               15.000000   1.000 
1.000  

1901118000 19A  Cilantro, leaves                   3.000000   1.000 
1.000  

1901118001 19A  Cilantro, leaves-babyfood          3.000000   1.000 
1.000  

1901144000 19A  Dillweed                           3.000000   1.000 
1.000  

1901184000 19A  Herbs, other                       3.000000   1.000 
1.000  

1901184001 19A  Herbs, other-babyfood              3.000000   1.000 
1.000  

1901202000 19A  Lemongrass                         3.000000   1.000 
1.000  

1901220000 19A  Marjoram                           3.000000   1.000 
1.000  

1901220001 19A  Marjoram-babyfood                  3.000000   1.000 
1.000  

1901249000 19A  Parsley, dried leaves            170.000000   1.000 
1.000  

1901249001 19A  Parsley, dried leaves-babyfood   170.000000   1.000 
1.000  

1901334000 19A  Savory                             3.000000   1.000 
1.000  

2001319000 20A  Rapeseed, oil                      0.030000   1.000 
1.000  

2001319001 20A  Rapeseed, oil-babyfood             0.030000   1.000 
1.000  

3100046000 31   Beef, meat byproducts              0.020000   1.000 
1.000  

3100046001 31   Beef, meat byproducts-babyfood     0.020000   1.000 
1.000  

3100048000 31   Beef, kidney                       0.020000   1.000 
1.000  

3100049000 31   Beef, liver                        0.020000   1.000 
1.000  

3100049001 31   Beef, liver-babyfood               0.020000   1.000 
1.000  

3200170000 32   Goat, meat byproducts              0.020000   1.000 
1.000  

3200172000 32   Goat, kidney                       0.020000   1.000 
1.000  

3200173000 32   Goat, liver                        0.020000   1.000 
1.000  

3500340000 35   Sheep, meat byproducts             0.020000   1.000 
1.000  

3500342000 35   Sheep, kidney                      0.020000   1.000 
1.000  

3500343000 35   Sheep, liver                       0.020000   1.000 
1.000  

8601000000 86A  Water, direct, all sources         0.034790   1.000 
1.000  

8602000000 86B  Water, indirect, all sources       0.034790   1.000 
1.000  

9500001000 O    Acerola                            1.500000   1.000 
1.000  

9500016000 O    Artichoke, globe                   4.000000   1.000 
1.000  

9500020000 O    Avocado                            1.200000   1.000 
1.000  

9500074000 O    Canistel                           1.200000   1.000 
1.000  

9500151000 O    Feijoa                             1.500000   1.000 
1.000  

9500177000 O    Grape, leaves                      3.000000   1.000 
1.000  

9500178000 O    Grape, raisin                      5.000000   1.000 
1.000  

9500183000 O    Guava                              1.500000   1.000 
1.000  

9500183001 O    Guava-babyfood                     1.500000   1.000 
1.000  

9500209000 O    Longan                             2.000000   1.000 
1.000  

9500211000 O    Lychee                             2.000000   1.000 
1.000  

9500212000 O    Lychee, dried                      2.000000   1.850 
1.000  

9500215000 O    Mango                              1.200000   1.000 
1.000  

9500215001 O    Mango-babyfood                     1.200000   1.000 
1.000  

9500216000 O    Mango, dried                       1.200000   1.000 
1.000  

9500217000 O    Mango, juice                       1.200000   1.000 
1.000  

9500217001 O    Mango, juice-babyfood              1.200000   1.000 
1.000  

9500245000 O    Papaya                             1.200000   1.000 
1.000  

9500245001 O    Papaya-babyfood                    1.200000   1.000 
1.000  

9500246000 O    Papaya, dried                      1.200000   1.800 
1.000  

9500247000 O    Papaya, juice                      1.200000   1.500 
1.000  

9500252000 O    Passionfruit                       1.500000   1.000 
1.000  

9500252001 O    Passionfruit-babyfood              1.500000   1.000 
1.000  

9500253000 O    Passionfruit, juice                1.500000   1.000 
1.000  

9500253001 O    Passionfruit, juice-babyfood       1.500000   1.000 
1.000  

9500289000 O    Pomegranate                       10.000000   1.000 
1.000  

9500333000 O    Sapote, Mamey                      1.200000   1.000 
1.000  

9500351000 O    Spanish lime                       2.000000   1.000 
1.000  

9500358000 O    Starfruit                          1.500000   1.000 
1.000  

9500398000 O    Watercress                        20.000000   1.000 
1.000  

Attachment 2 Chronic DEEM-FCID Residue Input File

Filename: C:\Users\tmorton\Documents\My Files\DEEM Files\288202
Cyprodinil\Cyprodinil 4E8273\288202CHRONICEPARECOMMENDATIONS.R08

Chemical: cyprodinil

RfD(Chronic): .03 mg/kg bw/day  NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): 1.5 mg/kg bw/day  NOEL(Acute):  0 mg/kg bw/day

Date created/last modified: 04-09-2015/09:10:28       Program ver. 3.16,
03-08-d

------------------------------------------------------------------------
-----------

   EPA     Crop                                   Def Res    
Adj.Factors   Comment

   Code     Grp  Commodity Name                    (ppm)       #1    #2 
 

---------- ---- -------------------------------  ----------  ------
------  -------

0101050000 1AB  Beet, garden, roots                0.750000   1.000 
1.000  

0101050001 1AB  Beet, garden, roots-babyfood       0.750000   1.000 
1.000  

0101067000 1AB  Burdock                            0.750000   1.000 
1.000  

0101078000 1AB  Carrot                             0.750000   1.000 
1.000  

0101078001 1AB  Carrot-babyfood                    0.750000   1.000 
1.000  

0101079000 1AB  Carrot, juice                      0.750000   1.000 
1.000  

0101084000 1AB  Celeriac                           0.750000   1.000 
1.000  

0101100000 1AB  Chicory, roots                     0.750000   1.000 
1.000  

0101168000 1AB  Ginseng, dried                     0.750000   1.000 
1.000  

0101190000 1AB  Horseradish                        0.750000   1.000 
1.000  

0101250000 1AB  Parsley, turnip rooted             0.750000   1.000 
1.000  

0101251000 1AB  Parsnip                            0.750000   1.000 
1.000  

0101251001 1AB  Parsnip-babyfood                   0.750000   1.000 
1.000  

0101314000 1AB  Radish, roots                      0.750000   1.000 
1.000  

0101316000 1AB  Radish, Oriental, roots            0.750000   1.000 
1.000  

0101327000 1AB  Rutabaga                           0.750000   1.000 
1.000  

0101331000 1AB  Salsify, roots                     0.750000   1.000 
1.000  

0101388000 1AB  Turnip, roots                      0.750000   1.000 
1.000  

0200051000 2    Beet, garden, tops                10.000000   1.000 
1.000  

0200101000 2    Chicory, tops                     10.000000   1.000 
1.000  

0200140000 2    Dasheen, leaves                   10.000000   1.000 
1.000  

0200315000 2    Radish, tops                      10.000000   1.000 
1.000  

0200317000 2    Radish, Oriental, tops            10.000000   1.000 
1.000  

0200332000 2    Salsify, tops                     10.000000   1.000 
1.000  

0301165000 3A   Garlic, bulb                       0.600000   1.000 
1.000  

0301165001 3A   Garlic, bulb-babyfood              0.600000   1.000 
1.000  

0301237000 3A   Onion, bulb                        0.600000   1.000 
1.000  

0301237001 3A   Onion, bulb-babyfood               0.600000   1.000 
1.000  

0301238000 3A   Onion, bulb, dried                 0.600000   9.000 
1.000  

0301238001 3A   Onion, bulb, dried-babyfood        0.600000   9.000 
1.000  

0301338000 3A   Shallot, bulb                      0.600000   1.000 
1.000  

0302103000 3B   Chive, fresh leaves                3.000000   1.000 
1.000  

0302198000 3B   Leek                               4.000000   1.000 
1.000  

0302239000 3B   Onion, green                       4.000000   1.000 
1.000  

0302338500 3B   Shallot, fresh leaves              4.000000   1.000 
1.000  

0401005000 4A   Amaranth, leafy                   50.000000   1.000 
1.000  

0401018000 4A   Arugula                           50.000000   1.000 
1.000  

0401104000 4A   Chrysanthemum, garland            50.000000   1.000 
1.000  

0401133000 4A   Cress, garden                     50.000000   1.000 
1.000  

0401134000 4A   Cress, upland                     50.000000   1.000 
1.000  

0401138000 4A   Dandelion, leaves                 50.000000   1.000 
1.000  

0401150000 4A   Endive                            50.000000   1.000 
1.000  

0401204000 4A   Lettuce, head                      0.870000   1.000 
1.000  

0401205000 4A   Lettuce, leaf                     13.000000   1.000 
1.000  

0401248000 4A   Parsley, leaves                   35.000000   1.000 
1.000  

0401313000 4A   Radicchio                         50.000000   1.000 
1.000  

0401355000 4A   Spinach                           11.800000   1.000 
1.000  

0401355001 4A   Spinach-babyfood                  11.800000   1.000 
1.000  

0402076000 4B   Cardoon                           30.000000   1.000 
1.000  

0402085000 4B   Celery                            30.000000   1.000 
1.000  

0402085001 4B   Celery-babyfood                   30.000000   1.000 
1.000  

0402086000 4B   Celery, juice                     30.000000   1.000 
1.000  

0402087000 4B   Celtuce                           30.000000   1.000 
1.000  

0402152000 4B   Fennel, Florence                  30.000000   1.000 
1.000  

0402322000 4B   Rhubarb                           30.000000   1.000 
1.000  

0402367000 4B   Swiss chard                       30.000000   1.000 
1.000  

0501061000 5A   Broccoli                           1.000000   1.000 
1.000  

0501061001 5A   Broccoli-babyfood                  1.000000   1.000 
1.000  

0501062000 5A   Broccoli, Chinese                  1.000000   1.000 
1.000  

0501064000 5A   Brussels sprouts                   1.000000   1.000 
1.000  

0501069000 5A   Cabbage                            1.000000   1.000 
1.000  

0501071000 5A   Cabbage, Chinese, napa             1.000000   1.000 
1.000  

0501072000 5A   Cabbage, Chinese, mustard          1.000000   1.000 
1.000  

0501083000 5A   Cauliflower                        1.000000   1.000 
1.000  

0501196000 5A   Kohlrabi                           1.000000   1.000 
1.000  

0502063000 5B   Broccoli raab                     10.000000   1.000 
1.000  

0502070000 5B   Cabbage, Chinese, bok choy        10.000000   1.000 
1.000  

0502117000 5B   Collards                          10.000000   1.000 
1.000  

0502194000 5B   Kale                              10.000000   1.000 
1.000  

0502229000 5B   Mustard greens                    10.000000   1.000 
1.000  

0502318000 5B   Rape greens                       10.000000   1.000 
1.000  

0502389000 5B   Turnip, greens                    10.000000   1.000 
1.000  

0602031000 6B   Bean, broad, succulent             0.600000   1.000 
1.000  

0602033000 6B   Bean, cowpea, succulent            0.600000   1.000 
1.000  

0602037000 6B   Bean, lima, succulent              0.600000   1.000 
1.000  

0603030000 6C   Bean, black, seed                  0.600000   1.000 
1.000  

0603032000 6C   Bean, broad, seed                  0.600000   1.000 
1.000  

0603034000 6C   Bean, cowpea, seed                 0.600000   1.000 
1.000  

0603035000 6C   Bean,  great northern, seed        0.600000   1.000 
1.000  

0603036000 6C   Bean, kidney, seed                 0.600000   1.000 
1.000  

0603038000 6C   Bean, lima, seed                   0.600000   1.000 
1.000  

0603039000 6C   Bean, mung, seed                   0.600000   1.000 
1.000  

0603040000 6C   Bean, navy, seed                   0.600000   1.000 
1.000  

0603041000 6C   Bean, pink, seed                   0.600000   1.000 
1.000  

0603042000 6C   Bean, pinto, seed                  0.600000   1.000 
1.000  

0603098000 6C   Chickpea, seed                     0.600000   1.000 
1.000  

0603098001 6C   Chickpea, seed-babyfood            0.600000   1.000 
1.000  

0603099000 6C   Chickpea, flour                    0.600000   1.000 
1.000  

0603182000 6C   Guar, seed                         0.600000   1.000 
1.000  

0603182001 6C   Guar, seed-babyfood                0.600000   1.000 
1.000  

0603203000 6C   Lentil, seed                       0.600000   1.000 
1.000  

0801374000 8A   Tomatillo                          0.160000   1.000 
1.000  

0801375000 8A   Tomato                             0.160000   1.000 
1.000  

0801375001 8A   Tomato-babyfood                    0.160000   1.000 
1.000  

0801376000 8A   Tomato, paste                      0.160000   1.000 
1.000  

0801376001 8A   Tomato, paste-babyfood             0.160000   1.000 
1.000  

0801377000 8A   Tomato, puree                      0.160000   1.000 
1.000  

0801377001 8A   Tomato, puree-babyfood             0.160000   1.000 
1.000  

0801378000 8A   Tomato, dried                      0.160000  14.300 
1.000  

0801378001 8A   Tomato, dried-babyfood             0.160000  14.300 
1.000  

0801379000 8A   Tomato, juice                      0.160000   1.000 
1.000  

0801380000 8A   Tomato, Tree                       0.160000   1.000 
1.000  

0802148000 8BC  Eggplant                           1.500000   1.000 
1.000  

0802234000 8BC  Okra                               1.500000   1.000 
1.000  

0802270000 8B   Pepper, bell                       1.500000   1.000 
1.000  

0802270001 8B   Pepper, bell-babyfood              1.500000   1.000 
1.000  

0802271000 8B   Pepper, bell, dried                1.500000   1.000 
1.000  

0802271001 8B   Pepper, bell, dried-babyfood       1.500000   1.000 
1.000  

0802272000 8BC  Pepper, nonbell                    1.500000   1.000 
1.000  

0802272001 8BC  Pepper, nonbell-babyfood           1.500000   1.000 
1.000  

0802273000 8BC  Pepper, nonbell, dried             1.500000   1.000 
1.000  

0901075000 9A   Cantaloupe                         0.700000   1.000 
1.000  

0901187000 9A   Honeydew melon                     0.700000   1.000 
1.000  

0901399000 9A   Watermelon                         0.700000   1.000 
1.000  

0901400000 9A   Watermelon, juice                  0.700000   1.000 
1.000  

0902021000 9B   Balsam pear                        0.700000   1.000 
1.000  

0902088000 9B   Chayote, fruit                     0.700000   1.000 
1.000  

0902102000 9B   Chinese waxgourd                   0.700000   1.000 
1.000  

0902135000 9B   Cucumber                           0.700000   1.000 
1.000  

0902308000 9B   Pumpkin                            0.700000   1.000 
1.000  

0902309000 9B   Pumpkin, seed                      0.700000   1.000 
1.000  

0902356000 9B   Squash, summer                     0.700000   1.000 
1.000  

0902356001 9B   Squash, summer-babyfood            0.700000   1.000 
1.000  

0902357000 9B   Squash, winter                     0.700000   1.000 
1.000  

0902357001 9B   Squash, winter-babyfood            0.700000   1.000 
1.000  

1001108000 10A  Citrus, oil                       60.000000   1.000 
1.000  

1002199000 10B  Lemon                              0.260000   1.000 
1.000  

1002200000 10B  Lemon, juice                       0.260000   1.000 
1.000  

1002200001 10B  Lemon, juice-babyfood              0.260000   1.000 
1.000  

1002201000 10B  Lemon, peel                        0.260000   1.000 
1.000  

1002206000 10B  Lime                               0.260000   1.000 
1.000  

1002207000 10B  Lime, juice                        0.260000   1.000 
1.000  

1002207001 10B  Lime, juice-babyfood               0.260000   1.000 
1.000  

1100007000 11   Apple, fruit with peel             0.500000   1.000 
1.000  PP#0F7

            Full comment: PP#0F7696

1100008000 11   Apple, peeled fruit                0.500000   1.000 
1.000  PP#0F7

            Full comment: PP#0F7696

1100008001 11   Apple, peeled fruit-babyfood       0.500000   1.000 
1.000  PP#0F7

            Full comment: PP#0F7696

1100009000 11   Apple, dried                       0.500000   8.000 
1.000  PP#0F7

            Full comment: PP#0F7696

1100009001 11   Apple, dried-babyfood              0.500000   8.000 
1.000  PP#0F7

            Full comment: PP#0F7696

1100010000 11   Apple, juice                       0.500000   1.300 
1.000  PP#0F7

            Full comment: PP#0F7696

1100010001 11   Apple, juice-babyfood              0.500000   1.300 
1.000  PP#0F7

            Full comment: PP#0F7696

1100011000 11   Apple, sauce                       0.500000   1.000 
1.000  PP#0F7

            Full comment: PP#0F7696

1100011001 11   Apple, sauce-babyfood              0.500000   1.000 
1.000  PP#0F7

            Full comment: PP#0F7696

1100129000 11   Crabapple                          0.500000   1.000 
1.000  PP#0F7

            Full comment: PP#0F7696

1100173500 11   Goji berry                         1.500000   1.000 
1.000  

1100210000 11   Loquat                             0.500000   1.000 
1.000  PP#0F7

            Full comment: PP#0F7696

1100266000 11   Pear                               0.380000   1.000 
1.000  PP#0F7

            Full comment: PP#0F7696

1100266001 11   Pear-babyfood                      0.380000   1.000 
1.000  PP#0F7

            Full comment: PP#0F7696

1100267000 11   Pear, dried                        0.380000   6.250 
1.000  PP#0F7

            Full comment: PP#0F7696

1100268000 11   Pear, juice                        0.380000   1.000 
1.000  PP#0F7

            Full comment: PP#0F7696

1100268001 11   Pear, juice-babyfood               0.380000   1.000 
1.000  PP#0F7

            Full comment: PP#0F7696

1100310000 11   Quince                             0.500000   1.000 
1.000  PP#0F7

            Full comment: PP#0F7696

1201090000 12A  Cherry                             2.000000   1.000 
1.000  

1201090001 12A  Cherry-babyfood                    2.000000   1.000 
1.000  

1201091000 12A  Cherry, juice                      2.000000   1.500 
1.000  

1201091001 12A  Cherry, juice-babyfood             2.000000   1.500 
1.000  

1202012000 12B  Apricot                            2.000000   1.000 
1.000  

1202012001 12B  Apricot-babyfood                   2.000000   1.000 
1.000  

1202013000 12B  Apricot, dried                     2.000000   6.000 
1.000  

1202014000 12B  Apricot, juice                     2.000000   1.000 
1.000  

1202014001 12B  Apricot, juice-babyfood            2.000000   1.000 
1.000  

1202230000 12B  Nectarine                          2.000000   1.000 
1.000  

1202260000 12B  Peach                              2.000000   1.000 
1.000  

1202260001 12B  Peach-babyfood                     2.000000   1.000 
1.000  

1202261000 12B  Peach, dried                       2.000000   7.000 
1.000  

1202261001 12B  Peach, dried-babyfood              2.000000   7.000 
1.000  

1202262000 12B  Peach, juice                       2.000000   1.000 
1.000  

1202262001 12B  Peach, juice-babyfood              2.000000   1.000 
1.000  

1203285000 12C  Plum                               2.000000   1.000 
1.000  

1203285001 12C  Plum-babyfood                      2.000000   1.000 
1.000  

1203286000 12C  Plum, prune, fresh                 2.000000   1.000 
1.000  

1203286001 12C  Plum, prune, fresh-babyfood        2.000000   1.000 
1.000  

1203287000 12C  Plum, prune, dried                 2.000000   5.000 
1.000  

1203287001 12C  Plum, prune, dried-babyfood        2.000000   5.000 
1.000  

1203288000 12C  Plum, prune, juice                 2.000000   1.400 
1.000  

1203288001 12C  Plum, prune, juice-babyfood        2.000000   1.400 
1.000  

1301055000 13A  Blackberry                        10.000000   1.000 
1.000  

1301056000 13A  Blackberry, juice                 10.000000   1.000 
1.000  

1301056001 13A  Blackberry, juice-babyfood        10.000000   1.000 
1.000  

1301058000 13A  Boysenberry                       10.000000   1.000 
1.000  

1301208000 13A  Loganberry                        10.000000   1.000 
1.000  

1301320000 13A  Raspberry                         10.000000   1.000 
1.000  

1301320001 13A  Raspberry-babyfood                10.000000   1.000 
1.000  

1301321000 13A  Raspberry, juice                  10.000000   1.000 
1.000  

1301321001 13A  Raspberry, juice-babyfood         10.000000   1.000 
1.000  

1302057000 13B  Blueberry                          3.000000   1.000 
1.000  

1302057001 13B  Blueberry-babyfood                 3.000000   1.000 
1.000  

1302136000 13B  Currant                            3.000000   1.000 
1.000  

1302137000 13B  Currant, dried                     3.000000   1.000 
1.000  

1302149000 13B  Elderberry                         3.000000   1.000 
1.000  

1302174000 13B  Gooseberry                         3.000000   1.000 
1.000  

1302191000 13B  Huckleberry                        3.000000   1.000 
1.000  

1304175000 13D  Grape                              0.810000   1.000 
1.000  

1304176000 13D  Grape, juice                       0.810000   1.200 
1.000  

1304176001 13D  Grape, juice-babyfood              0.810000   1.200 
1.000  

1304179000 13D  Grape, wine and sherry             0.810000   1.000 
1.000  

1304195000 13D  Kiwifruit, fuzzy                   1.800000   1.000 
1.000  

1307359000 13G  Strawberry                         5.000000   1.000 
1.000  

1307359001 13G  Strawberry-babyfood                5.000000   1.000 
1.000  

1307360000 13G  Strawberry, juice                  5.000000   1.000 
1.000  

1307360001 13G  Strawberry, juice-babyfood         5.000000   1.000 
1.000  

1400003000 14   Almond                             0.020000   1.000 
1.000  

1400003001 14   Almond-babyfood                    0.020000   1.000 
1.000  

1400004000 14   Almond, oil                        0.020000   1.000 
1.000  

1400004001 14   Almond, oil-babyfood               0.020000   1.000 
1.000  

1400282000 14   Pistachio                          0.100000   1.000 
1.000  

1901028000 19A  Basil, fresh leaves                3.000000   1.000 
1.000  

1901028001 19A  Basil, fresh leaves-babyfood       3.000000   1.000 
1.000  

1901029000 19A  Basil, dried leaves               15.000000   1.000 
1.000  

1901029001 19A  Basil, dried leaves-babyfood      15.000000   1.000 
1.000  

1901102500 19A  Chive, dried leaves               15.000000   1.000 
1.000  

1901118000 19A  Cilantro, leaves                   3.000000   1.000 
1.000  

1901118001 19A  Cilantro, leaves-babyfood          3.000000   1.000 
1.000  

1901144000 19A  Dillweed                           3.000000   1.000 
1.000  

1901184000 19A  Herbs, other                       3.000000   1.000 
1.000  

1901184001 19A  Herbs, other-babyfood              3.000000   1.000 
1.000  

1901202000 19A  Lemongrass                         3.000000   1.000 
1.000  

1901220000 19A  Marjoram                           3.000000   1.000 
1.000  

1901220001 19A  Marjoram-babyfood                  3.000000   1.000 
1.000  

1901249000 19A  Parsley, dried leaves            170.000000   1.000 
1.000  

1901249001 19A  Parsley, dried leaves-babyfood   170.000000   1.000 
1.000  

1901334000 19A  Savory                             3.000000   1.000 
1.000  

2001319000 20A  Rapeseed, oil                      0.030000   1.000 
1.000  

2001319001 20A  Rapeseed, oil-babyfood             0.030000   1.000 
1.000  

3100046000 31   Beef, meat byproducts              0.020000   1.000 
1.000  

3100046001 31   Beef, meat byproducts-babyfood     0.020000   1.000 
1.000  

3100048000 31   Beef, kidney                       0.020000   1.000 
1.000  

3100049000 31   Beef, liver                        0.020000   1.000 
1.000  

3100049001 31   Beef, liver-babyfood               0.020000   1.000 
1.000  

3200170000 32   Goat, meat byproducts              0.020000   1.000 
1.000  

3200172000 32   Goat, kidney                       0.020000   1.000 
1.000  

3200173000 32   Goat, liver                        0.020000   1.000 
1.000  

3500340000 35   Sheep, meat byproducts             0.020000   1.000 
1.000  

3500342000 35   Sheep, kidney                      0.020000   1.000 
1.000  

3500343000 35   Sheep, liver                       0.020000   1.000 
1.000  

8601000000 86A  Water, direct, all sources         0.024650   1.000 
1.000  

8602000000 86B  Water, indirect, all sources       0.024650   1.000 
1.000  

9500001000 O    Acerola                            1.500000   1.000 
1.000  

9500016000 O    Artichoke, globe                   4.000000   1.000 
1.000  

9500020000 O    Avocado                            1.200000   1.000 
1.000  

9500074000 O    Canistel                           1.200000   1.000 
1.000  

9500151000 O    Feijoa                             1.500000   1.000 
1.000  

9500177000 O    Grape, leaves                      0.810000   1.000 
1.000  

9500178000 O    Grape, raisin                      5.000000   1.000 
1.000  

9500183000 O    Guava                              1.500000   1.000 
1.000  

9500183001 O    Guava-babyfood                     1.500000   1.000 
1.000  

9500209000 O    Longan                             2.000000   1.000 
1.000  

9500211000 O    Lychee                             2.000000   1.000 
1.000  

9500212000 O    Lychee, dried                      2.000000   1.850 
1.000  

9500215000 O    Mango                              1.200000   1.000 
1.000  

9500215001 O    Mango-babyfood                     1.200000   1.000 
1.000  

9500216000 O    Mango, dried                       1.200000   1.000 
1.000  

9500217000 O    Mango, juice                       1.200000   1.000 
1.000  

9500217001 O    Mango, juice-babyfood              1.200000   1.000 
1.000  

9500245000 O    Papaya                             1.200000   1.000 
1.000  

9500245001 O    Papaya-babyfood                    1.200000   1.000 
1.000  

9500246000 O    Papaya, dried                      1.200000   1.800 
1.000  

9500247000 O    Papaya, juice                      1.200000   1.500 
1.000  

9500252000 O    Passionfruit                       1.500000   1.000 
1.000  

9500252001 O    Passionfruit-babyfood              1.500000   1.000 
1.000  

9500253000 O    Passionfruit, juice                1.500000   1.000 
1.000  

9500253001 O    Passionfruit, juice-babyfood       1.500000   1.000 
1.000  

9500289000 O    Pomegranate                       10.000000   1.000 
1.000  

9500333000 O    Sapote, Mamey                      1.200000   1.000 
1.000  

9500351000 O    Spanish lime                       2.000000   1.000 
1.000  

9500358000 O    Starfruit                          1.500000   1.000 
1.000  

9500398000 O    Watercress                        20.000000   1.000 
1.000  

Attachment 3  Results of Acute DEEM-FCID Dietary Exposure Analysis

 

US EPA                                                      Ver. 3.18,
03-08-d

DEEM-FCID ACUTE Analysis for CYPRODINIL                  NHANES
2003-2008 2-Day

Residue file: 288202 Acute Food and Water.R08     Adjustment factor #2
NOT used.

Analysis Date: 04-09-2015/09:51:29    Residue file dated:
04-09-2015/09:44:19

RAC/FF intake summed over 24 hours

Run Comment: ""

========================================================================
=======

Summary calculations--per capita:

                   95th Percentile      99th Percentile     99.9th
Percentile

                   Exposure   % aRfD    Exposure   % aRfD    Exposure  
% aRfD 

                  ---------- --------  ---------- --------  ----------
--------

Total US Population:

                    0.095198     4.76    0.181584     9.08    0.310238  
 15.51 

All Infants:

                    0.101588     5.08    0.168263     8.41    0.529152  
 26.46 

Children 1-2:

                    0.172629     8.63    0.277215    13.86    0.443582  
 22.18 

Children 3-5:

                    0.158663     7.93    0.253670    12.68    0.412075  
 20.60 

Children 6-12:

                    0.083374     4.17    0.178317     8.92    0.276162  
 13.81 

Youth 13-19:

                    0.071553     3.58    0.141338     7.07    0.295995  
 14.80 

Adults 20-49:

                    0.091866     4.59    0.182137     9.11    0.314326  
 15.72 

Adults 50-99:

                    0.091595     4.58    0.154312     7.72    0.272418  
 13.62 

Female 13-49:

                    0.096706     4.84    0.187550     9.38    0.327236  
 16.36 

                                                           

FOOD ONLY

US EPA                                                      Ver. 3.18,
03-08-d

DEEM-FCID ACUTE Analysis for CYPRODINIL                  NHANES
2003-2008 2-Day

Residue file: 288202 Acute Food Only.R08          Adjustment factor #2
NOT used.

Analysis Date: 04-09-2015/09:54:10    Residue file dated:
04-09-2015/09:46:11

RAC/FF intake summed over 24 hours

Run Comment: ""

========================================================================
=======

Summary calculations--per capita:

                   95th Percentile      99th Percentile     99.9th
Percentile

                   Exposure   % aRfD    Exposure   % aRfD    Exposure  
% aRfD 

                  ---------- --------  ---------- --------  ----------
--------

Total US Population:

                    0.094428     4.72    0.179943     9.00    0.309314  
 15.47 

All Infants:

                    0.099629     4.98    0.167443     8.37    0.528808  
 26.44 

Children 1-2:

                    0.172240     8.61    0.275992    13.80    0.445942  
 22.30 

Children 3-5:

                    0.157732     7.89    0.254669    12.73    0.408825  
 20.44 

Children 6-12:

                    0.082435     4.12    0.177091     8.85    0.274520  
 13.73 

Youth 13-19:

                    0.071135     3.56    0.139976     7.00    0.295949  
 14.80 

Adults 20-49:

                    0.091013     4.55    0.180252     9.01    0.312594  
 15.63 

Adults 50-99:

                    0.090599     4.53    0.153660     7.68    0.270453  
 13.52 

Female 13-49:

                    0.095958     4.80    0.187084     9.35    0.325861  
 16.29 

                                                            

Attachment 4  Results of Chronic DEEM-FCID Dietary Exposure Analysis

US EPA                                                          Ver.
3.16, 03-08-d

DEEM-FCID Chronic analysis for CYPRODINIL                  NHANES
2003-2008 2-day

Residue file name: C:\Users\tmorton\Documents\My Files\DEEM Files\288202
Cyprodinil\Cyprodinil 4E8273\288202 Chronic Food and Water.R08

                                                     Adjustment factor
#2 used.

Analysis Date 04-09-2015/09:48:31     Residue file dated:
04-09-2015/09:43:22

Reference dose (RfD, Chronic) = .027 mg/kg bw/day

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg             Percent
of   

           Subgroup                       body wt/day             Rfd   
   

--------------------------------------   -------------      
----------------

Total US Population                         0.007794               
28.9%

Hispanic                                    0.007303               
27.0%

Non-Hisp-White                              0.008032               
29.7%

Non-Hisp-Black                              0.006325               
23.4%

Non-Hisp-Other                              0.009383               
34.8%

Nursing Infants                             0.008687               
32.2%

Non-Nursing Infants                         0.014986               
55.5%

Female 13+ PREG                             0.006602               
24.5%

Children 1-6                                0.018324               
67.9%

Children 7-12                               0.007696               
28.5%

Male 13-19                                  0.004191               
15.5%

Female 13-19/NP                             0.005153               
19.1%

Male 20+                                    0.006066               
22.5%

Female 20+/NP                               0.007731               
28.6%

Seniors 55+                                 0.007840               
29.0%

All Infants                                 0.013042               
48.3%

Female 13-50                                0.006754               
25.0%

Children 1-2                                0.023045               
85.4%

Children 3-5                                0.016592               
61.5%

Children 6-12                               0.008522               
31.6%

Youth 13-19                                 0.004665               
17.3%

Adults 20-49                                0.006327               
23.4%

Adults 50-99                                0.007772               
28.8%

Female 13-49                                0.006706               
24.8%

------------------------------------------------------------------------
-------

FOOD ONLY

US EPA                                                          Ver.
3.16, 03-08-d

DEEM-FCID Chronic analysis for CYPRODINIL                  NHANES
2003-2008 2-day

Residue file name: C:\Users\tmorton\Documents\My Files\DEEM Files\288202
Cyprodinil\Cyprodinil 4E8273\288202 Chronic Food Only.R08

                                                     Adjustment factor
#2 used.

Analysis Date 04-09-2015/09:49:01     Residue file dated:
04-09-2015/09:47:27

Reference dose (RfD, Chronic) = .027 mg/kg bw/day

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg             Percent
of   

           Subgroup                       body wt/day             Rfd   
   

--------------------------------------   -------------      
----------------

Total US Population                         0.007277               
27.0%

Hispanic                                    0.006810               
25.2%

Non-Hisp-White                              0.007501               
27.8%

Non-Hisp-Black                              0.005899               
21.8%

Non-Hisp-Other                              0.008788               
32.5%

Nursing Infants                             0.008220               
30.4%

Non-Nursing Infants                         0.013270               
49.1%

Female 13+ PREG                             0.006116               
22.7%

Children 1-6                                0.017663               
65.4%

Children 7-12                               0.007266               
26.9%

Male 13-19                                  0.003836               
14.2%

Female 13-19/NP                             0.004755               
17.6%

Male 20+                                
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Female 13-50                                0.006241               
23.1%

Children 1-2                                0.022300               
82.6%

Children 3-5                                0.015965               
59.1%

Children 6-12                               0.008070               
29.9%

Youth 13-19                                 0.004289               
15.9%

Adults 20-49                                0.005812               
21.5%

Adults 50-99                                0.007263               
26.9%

Female 13-49                                0.006193               
22.9%

------------------------------------------------------------------------
-------

Cyprodinil (PC Code 288202)	Dietary Exposure and Risk Assessment        
         DP # 425997:   

Page  PAGE  1  of  NUMPAGES  19 

