                 UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
                            WASHINGTON, D.C.  20460
                                       
                                       
                                                  OFFICE OF CHEMICAL SAFETY AND
                                                  POLLUTION PREVENTION

MEMORANDUM

DATE:  	11/7/2014 

SUBJECT:	Metconazole Acute and Chronic Aggregate Dietary (Food and Drinking Water) Exposure and Risk Assessment for the Section 3 Registration Actions on Pea and Bean, Dried Shelled, except Soybean, Subgroup 6C and the Sunflower Subgroup 20B; Expansion of the Canola Tolerance to the Rapeseed Subgroup 20A; and Conversion of the Established Stone Fruit and Tree Nut Crop Groups to the Stone Fruit Group 12-12 and the Tree Nut Group 14-12.

PC Code:  125619
DP Number:  D423622
Decision No.:  487580
Registration No.:  59639-147
Petition No.:  4E8244
Regulatory Action:  Section 3 Registration
Risk Assessment Type:  Dietary Exposure 
Case No.:  NA
TXR No.:  NA
CAS No.:  125116-23-6
MRID No.:  NA
40 CFR:  §180.617

FROM:	Nancy Dodd, Chemist
		Risk Assessment Branch III (RAB3)
      Health Effects Division (HED; 7509P)

THROUGH:  Mohsen Sahafeyan, Chemist
		Seyed Tadayon, Chemist 
            Dietary Exposure Science Advisory Council (DESAC)
            	
TO:		Barry O'Keefe, Risk Assessor
      RAB3/HED (7509P)
			and
		Barbara Madden, PM #05
      Minor Use and Emergency Response Branch 
      Registration Division (RD; 7505P)

	
Executive Summary

Acute and chronic aggregate dietary (food and drinking water) exposure and risk assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM-FCID) Version 3.16.  This software uses 2003-2008 food consumption data from the U.S. Department of Agriculture's (USDA's) National Health and Nutrition Examination Survey, What We Eat in America (NHANES/WWEIA).  The analyses were conducted in support of a human-health risk assessment for the proposed Section 3 uses of metconazole on the pea and bean, dried shelled, except soybean, subgroup 6C and the sunflower subgroup 20B; expansion of the canola tolerance to the rapeseed subgroup 20A; and conversion of the established stone fruit and tree nut crop groups to the stone fruit group 12-12 and the tree nut group 14-12.  This memorandum was reviewed by two peer reviewers of the DESAC, per DESAC SOP 2012.1. 

Acute Dietary (Food and Drinking Water) Exposure Assessment

An unrefined acute dietary (food and drinking water) exposure assessment was conducted.  The residue levels used in the assessment were the established or recommended tolerance levels except for cereal grains and livestock commodities.  Since cereal grains and livestock commodities include metabolites as residues of concern in the risk assessment, maximum residue values for the metabolites from field trials were added to the metconazole tolerance levels.  DEEM default processing factors or empirical processing factors were used, as available.  It was assumed that 100% of the crops were treated.  

The estimated drinking water concentration (EDWC) used in the acute dietary assessment was provided by the Environmental Fate and Effects Division (EFED) and incorporated directly into the acute assessment.  The groundwater EDWC of 51.8 ug/L (ppb) generated by the PRZM-Ground Water (PRZM-GW) model was used in the acute dietary assessment.  The highest application rate, which was the application rate for turf, was modeled using the WI Central Sand Scenario in estimating metconazole EDWCs for groundwater.  

The acute dietary (food and drinking water) exposure to metconazole is below HED's level of concern for females 13-49 years old, the only population subgroup of concern.  For the general U.S. population, including infants and children, an appropriate dose/endpoint attributable to a single dose was not observed in the available oral toxicity studies.  The acute dietary exposure estimate at the 95[th] percentile is 4.6% of the aPAD for females 13-49 years old, the only population subgroup of concern.

Chronic Dietary (Food and Drinking Water) Exposure Assessment

An unrefined chronic dietary (food and drinking water) exposure assessment was conducted.  The residue levels used in the assessment were the established or recommended tolerance levels except for cereal grains and livestock commodities.  Since cereal grains and livestock commodities include metabolites as residues of concern in the risk assessment, maximum residue values for the metabolites from field trials were added to the metconazole tolerance levels.  DEEM default processing factors or empirical processing factors were used, as available.  It was assumed that 100% of the crops were treated.  

The EDWC used in the chronic dietary assessment was provided by EFED and incorporated directly into the chronic assessment.  The surface water EDWC of 43.9 ug/L (ppb) generated by the Surface Water Concentration Calculator (SWCC) model was used in the chronic dietary assessment.  The SWCC model was used to generate EDWCs for the Tier II aquatic exposure assessment based on the cranberry scenario.  The SWCC is a graphical user interface that runs the Pesticide Root Zone Model (PRZM, v 5, November 15, 2006) and the Variable Volume Water Body Model (VVWM, 3/6/2014) (USEPA, 2006b).  The default percent cropped area (PCA) factor of 1.0 was used.

The chronic dietary (food and drinking water) exposure to metconazole is below HED's level of concern for the general U.S. population and all population subgroups.  The chronic dietary exposure estimates are 6.6% of the cPAD for the general U.S. population and 14% of the cPAD for children 1-2 years old, the most highly exposed population subgroup.

Cancer Exposure Results and Characterization

Metconazole was classified as "not likely to be carcinogenic to humans;" therefore, a cancer dietary assessment was not performed. 

I.	Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide.  For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health effects).  This dose is referred to as the population adjusted dose (PAD).  The PAD is equivalent to the point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD.  References which discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site:  "Available Information on Assessing Exposure from Pesticides, A User's Guide," 6/21/2000, web link:  http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf; or see SOP 99.6 (8/20/1999).

The most recent dietary risk assessment for metconazole was conducted by Amelia Acierto (3/28/2011, D387504).
			
II.	Residue Information

Residues of Concern:  The residues of concern for the tolerance expression and risk assessment (DP# 348234, C. Olinger, 2/11/2008) are summarized in Table 1 below.
The triazole metabolites (1,2,4-triazole, triazolylalanine, and triazolylacetic acid) are also residues of concern, but they are addressed in a separate dietary exposure assessment document (DP# 414951, T. Morton, 10/24/13).

Table 1.  Summary of Metabolites and Degradates to be included in the Risk Assessment and Tolerance Expression[1][,2]
Matrix
Residues Included In Risk Assessment
Residues Included In Tolerance Expression
Plants


Primary and Rotational Crops, except Cereal Grains
Metconazole
Metconazole

Primary and Rotational Crops, Cereal Grains only
Metconazole and M11
Metconazole
Livestock

Metconazole; M1 and its glucuronic acid conjugate; M12; M31 and its glucuronic acid conjugate
Metconazole
Drinking Water

Metconazole
Not Applicable
1  For all triazole-containing pesticides, 1,2,4-triazole, triazolylalanine (TA), and triazolylacetic acid (TAA) should also be included as residues of concern for risk assessment purposes only for plant and livestock commodities.  Since these metabolites are common to the entire class of triazole-derivative fungicides and because of differential toxicity between the metabolites and the various parent compounds, risks associated with exposure to 1,2,4-T and to TA/TAA are addressed in separate risk assessment documents.
2  M1 = 5-[(4-chlorophenyl)methyl]-2-methoxyl-2-methyl-1-(1H-1,2,4-triazol-1-ylmethyl)-1-cyclopentanol;  M11 = 5-[(4-chlorophenyl)methoxyl]-2,2-dimethyl-1-(1H-1,2,4-triazol-1-ylmethyl)-1-cyclopentanol; M12 = 5-[(4-chlorophenyl)methyl]-2-carboxyl-2-methyl-1-(1H-1,2,4-triazol-1-ylmethyl)-1-cyclopentanol; M31 = (1S*,3R*,5S*)-3-hydroxy-cis-metconazole; 1,2,4-T = 1H-1,2,4-triazole; TAA = 1H-1,2,4-triazol-1-yl acetic acid; TA = 2-amino-3-(1H-1,2,4-triazol-1-yl)propanoic acid.

Established Tolerances:  Tolerances are established under 40 CFR §180.617 for residues of metconazole, including its metabolites and degradates, on a variety of raw agricultural commodities.  Compliance with the tolerance levels is to be determined by measuring only metconazole as the sum of its cis- and trans-isomers.  Permanent tolerances have been established for a variety of raw agricultural and processed commodities.  Time-limited tolerances, set to expire on 12/31/14, have also been established on sugarcane cane and molasses.

Recommended Tolerances: In PP#4E8244 (as shown in Table 2 below), the Interregional Research Project No. 4 (IR-4), on behalf of the IR-4 Project and the Agricultural Experiment Stations of Montana, South Dakota, North Dakota, and Colorado (dry bean), Montana, South Dakota, Idaho, and North Dakota (dry pea), and Kansas, Montana, South Dakota and North Dakota (sunflower), requested the establishment of permanent tolerances and registration for use on the pea and bean, dried shelled, except soybean, subgroup 6C, and the sunflower subgroup 20B; expansion of the canola tolerance to the rapeseed subgroup 20A; and conversion of the established stone fruit crop group 12 and tree nut crop group 14 to the stone fruit crop group 12-12 and the tree nut crop group 14-12. 



Table 2.  Recommended Metconazole Tolerances for PP#4E8244.
                                   Commodity
                       HED-Recommended Tolerances (ppm)
Pea and bean, dried shelled, except soybean, subgroup 6C
                                     0.15
Sunflower subgroup 20B
                                      0.7
Rapeseed subgroup 20A
                                     0.08
Fruit, stone, group 12-12
                                      0.2
Nut, tree, group 14-12
                                     0.04


Residue Values Used in This Assessment:  The residue levels used in the assessment are the established or recommended tolerance levels except for cereal grains and livestock commodities.  Since cereal grains and livestock commodities include metabolites as residues of concern in the risk assessment, maximum residue values for the metabolites from field trials were added to the metconazole tolerance levels.  Residue values used for cereal grains and livestock commodities are shown in Table 3 below:


Table 3.  Residue Values Used in DEEM for Cereal Grains and Livestock Commodities
Commodities
HED Recommended Tolerances - Parent only (ppm)
Maximum Residue Level For Metabolites (ppm, parent equivalents)
Residue Values Used in DEEM (ppm)[1]
Corn, field, grain
0.02
M11 (0.01)
0.03
Corn, pop, grain
0.02
M11 (0.01)
0.03
Corn, sweet, kernel plus cob with husk removed
0.01
M11 (0.01)
0.02
Small grains
Barley, grain
2.5
M11 (0.33)
2.83

Oat, grain
1.0
M11 (0.34)
1.34

Rye, grain
0.25
M11 (0.04)
0.29

Wheat, grain
0.15
M11 (0.03)
0.18
Cattle, meat byproducts
0.04
M1 (0.02)
M12 (0.02)
M31 (0.02)
0.10
Goat, meat byproducts



Horse, meat byproducts



Sheep, meat byproducts



Egg
0.04
M1 (0.02)
M12 (0.02)
M31 (0.02)
0.10
1 For cereal grains and livestock commodities, the residue values used in the DEEM include the sum of parent (tolerance) and metabolite(s), reported as parent equivalents.  Residues in meat byproducts and eggs are <LOQ (<0.02 ppm for each analyte).
.  
Processing Factors:  DEEM default processing factors were used for apricot, dried (6.0x), banana/plantain, dried (3.9x), cherry juice (1.5x), corn, field, syrup (1.5x), cranberry juice (1.1x), peach, dried (7.0x), peanut butter (1.89x), and plum, prune, juice (1.4x).

Empirical processing factors, based on processing studies, were used for the bran of barley, oat, and wheat (2.0x), wheat flour (1x), wheat germ (1x), soybean oil (1x), sugarcane, sugar (1x) (all D348168, N. Dodd, 2/20/08; processing factors for barley, oat and wheat commodities include residues of parent and metabolite M11 from MRID 46902231); potato commodities (potato, chips; potato, dry) (1x) (D380990, A. Acierto, 3/24/11); rapeseed oil/sesame oil (1x) (D419223, N. Dodd, 11/4/14), and sunflower oil (1x) (D419223, N. Dodd, 11/4/14).  (The processing factor of 1x was used for processing factors which were <=1x.)  A separate tolerance was established for sugarcane molasses under a Section 18 (D341748, B. O'Keefe, 8/15/08); therefore, the processing factor was set to 1.  Separate tolerances were established for peanut oil and sugar beet molasses; therefore, the processing factors were set to 1 (D348168, N. Dodd, 2/20/08).  Although concentration was observed in dried prune (2.3x), it was determined that the tolerance for the raw agricultural commodity is adequate to cover the residues in the processed commodity (D348168, N. Dodd, 2/20/08); therefore, the processing factor for dried prune is set to 1.

The USDA Pesticide Data Program (PDP) monitored pesticide residues in catfish in 2008, 2009, and 2010; however, the samples were not analyzed for metconazole.  As a result, residues in fish were not included in the assessment.

III.	Percent Crop Treated
 
100% crop treated (100% CT) was assumed for all commodities.
 
IV.	Drinking Water Data

The drinking water residues used in the dietary risk assessment were provided by the Environmental Fate and Effects Division (EFED) in the following memorandum: "Drinking Water Exposure Assessment for the Section 3 New Use of Metconazole on Pea and Bean (Dried Shelled, Subgroup 6C), and Sunflower (Subgroup 20B)" (D418674, Faruque Khan, Ph.D., 9/30/14) and incorporated directly into this dietary assessment.  Water residues were incorporated in the DEEM-FCID into the food categories "water, direct, all sources" and "water, indirect, all sources."   

Metconazole parent is the only residue of concern considered in the drinking water assessment.  No degradates of metconazole were included based on the recommendation from the Residues of Concern Knowledgebase Subcommittee (ROCKS) of HED (USEPA, 2008, D348234). 

For surface water, the Surface Water Concentration Calculator (SWCC v 1.106) model was used to generate EDWCs for the Tier II aquatic exposure assessment based on cranberry use. The SWCC is a graphical user interface that runs the Pesticide Root Zone Model (PRZM, v 5, November 15, 2006) and the Variable Volume Water Body Model (VVWM, 3/6/2014) (USEPA, 2006b).  The default percent cropped area (PCA) factor of 1.0 was used.
For peak exposure and annual mean exposure, lower EDWCs for surface water were generated using the Tier II Pesticide Root Zone Model and Exposure Analysis Modeling System (PRZM-EXAMS), based on metconazole use on PA turf with a PCA factor of 1.  The use on turf reflected the highest application rate (i.e., five applications at 0.6 lb ai/A/application with a 14-day retreatment interval).  The modeled EDWCs for pea/bean (dried shelled) and sunflower did not exceed the concentrations from PA turf.  
For groundwater, the PRZM-Ground Water (PRZM-GW) model was used to estimate EDWCs.  The highest application rate, which was the application rate for turf, was modeled in estimating metconazole EDWCs for groundwater.  Since application rates for proposed uses are lower than turf, no additional PRZM-GW modeling was conducted. 

The EDWCs used in HED's human health dietary risk assessment are bolded in summary Table 4 below.   The groundwater EDWC of 51.8 ug/L (ppb) was used in the acute dietary assessment. The surface water EDWC of 43.9 ug/L (ppb) was used in the chronic dietary assessment.

Table 4.  Recommended EDWCs for the Proposed Uses of Metconazole for Drinking Water Sources[1] 
Drinking Water Source
Crop Scenario (Model)
                                 Peak Exposure
                                    (Acute)
                                    (ug/L)
                             Annual Mean Exposure 
                             (Non-Cancer Chronic)
                                    (μg/L)
                            30-year Mean Exposure 
                               (Cancer Chronic)
                                   (ug/L) 
Surface Water
Turf [2] 
                                     45.5
                                     31.3
                                     22.8

Cranberry[3] 
                                     49.6
                                     43.9
                                     NA[5]
Groundwater
WI Central Sand Scenario[4] 
                                     51.8
                                     NA[5]
                                     20.0
[1] Bolded values are the recommended EDWCs for assessing acute and chronic dietary exposures from metconazole uses.
2 The Tier II model PRZM/EXAMS was used to generate EDWCs for surface water, based on metconazole use on PA turf.  A percent cropped area (PCA) factor of 1 was used.
[3] The SWCC v 1.106 model was used to generate EDWCs for the Tier II aquatic exposure assessment. The SWCC is a graphical user interface that runs the Pesticide Root Zone Model (PRZM, v 5, November 15, 2006) and the Variable Volume Water Body Model (VVWM, 3/6/2014) (USEPA, 2006b). The default PCA factor of 1.0 was used.
[4] The Tier 1 PRZM-GW model was used to reassess groundwater EDWCs for the turf use, which has the highest application rate (5 applications at of 0.6 lbs ai/A/application).
[5] Not applicable.


The drinking water models and their descriptions are available at the EPA internet site: http://www.epa.gov/oppefed1/models/water/. 


V.  DEEM-FCID Program and Consumption Information

Metconazole acute and chronic dietary exposure assessments were conducted using the DEEM-FCID, Version 3.16, which incorporates 2003-2008 consumption data from USDA's NHANES/WWEIA.  The data are based on the reported consumption of more than 20,000 individuals over two non-consecutive survey days.  Foods "as consumed" (e.g., apple pie) are linked to EPA-defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA.  For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups.  However, for acute exposure assessment, consumption data are retained as individual consumption events.  Based on analysis of the 2003-2008 WWEIA consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50-99 years old.

For a chronic dietary exposure assessment, an estimate of the residue level in each food or food-form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food form to produce a residue intake estimate.  The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure.  Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD.  This procedure is performed for each population subgroup.

For an acute exposure assessment, individual one-day food consumption data are used on an individual-by-individual basis.  The reported consumption amounts of each food item can be multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or "matched" in multiple random pairings with residue values and then summed in a probabilistic assessment.  The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating relevant commodities/food forms) and a per-capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis.  In accordance with HED policy, per capita exposure and risk are reported for analyses performed at all levels of refinement.  However, for deterministic assessments, any significant differences in user vs. per capita exposure and risk are specifically identified and noted in the risk assessment.

VI.  Toxicological Information

The risk assessment team selected endpoints or confirmed endpoints that were selected previously.  The Cancer Assessment Review Committee (CARC) for metconazole met on November 2, 2005 (memo, Gregory Akerman, Ph.D., TXR# 0054211, 4/14/06).  The Metconazole Endpoint Selection meeting was held on December 21, 2005.  The Toxicity Advisory Clinic (TAC) met on 1/10/06 to discuss the acute hazard endpoint selection and the FQPA selection.   

The critical studies in which HED has high confidence suggest a low (or no) level of concern for pup susceptibility.  Other data in which HED has a lower level of confidence suggests some level of concern for pup susceptibility.   Taken together, there is low concern (and thus low uncertainty) that the young are more susceptible than adults to metconazole exposures.  Thus, the FQPA factor has been removed (i.e., reduced to 1X). 

A summary of toxicological endpoints for use in human health risk assessment is presented below in Table 5:


Table 5.  Summary of Toxicological Doses and Endpoints for Metconazole for Use in Dietary and Non-Occupational Human Health Risk Assessments
Exposure/
Scenario
Point of Departure
Uncertainty/FQPA Safety Factors
RfD, PAD, Level of Concern for Risk Assessment
Study and Toxicological Effects
Acute Dietary (General Population, including Infants and Children)

An appropriate dose/endpoint attributable to a single dose was not observed in the available oral toxicity studies.	

Acute Dietary
(Females 13-49 years of age)
NOAEL= 12 mg/kg/day
UFA= 10x
UFH= 10x
FQPA SF= 1x

Acute RfD = 0.12 mg/kg/day

aPAD= 0.12 mg/kg/day
Developmental toxicity in rats: LOAEL= 30 mg/kg/day based on increases in skeletal variations (predominantly lumbar ribs).
Chronic Dietary (All Populations)
NOAEL= 4.3 mg/kg/day
UFA=10x
UFH= 10x
FQPA SF= 1x

Chronic RfD = 0.04 mg/kg/day

cPAD = 0.04 mg/kg/day
Chronic oral toxicity study in rats: LOAEL = 13.1 mg/kg/day based on increased liver (M) weights and associated  hepatocellular  lipid vacuolation (M) and centrilobular hypertrophy(M).  Same effects seen in F at 54 mg/kg/day, plus increased spleen wt.
Cancer (oral, dermal, inhalation)
Classification:  "Not likely to be Carcinogenic to Humans" based on convincing evidence that carcinogenic effects are not likely below a defined dose range.  A non-genotoxic mode of action for mouse liver tumors was established.  No quantification is required.	
Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and  
used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human 
 exposures.  NOAEL = no observed adverse effect level.  LOAEL = lowest observed adverse effect level.  UF = 
uncertainty factor.  UFA = extrapolation from animal to human (interspecies).  UFH = potential variation in sensitivity
among members of the human population (intraspecies).  FQPA SF = FQPA Safety Factor.  PAD = population adjusted dose (a = acute, c = chronic). 


VII.  Results/Discussion 

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the PAD.  The DEEM-FCID analyses estimate the dietary exposure and risk of the U.S. population and various population subgroups.  The results reported in Table 6 are for the general U.S. Population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, females 13-49, adults 20-49, and adults 50-99 years old.

Results of Acute Dietary (Food and Drinking Water) Exposure and Risk Analysis

The results of the acute dietary (food and drinking water) exposure and risk analysis at the 95[th] percentile of exposure are reported in Table 6, below.  The acute assessment was performed for females 13-49 years old only, since an acute endpoint was not identified for the general U.S. population.  The acute dietary (food and drinking water) exposure is 4.6% of the aPAD for females 13-49.
 
Results of Chronic Dietary (Food and Drinking Water) Exposure and Risk Analysis

The results of the chronic dietary (food and drinking water) exposure and risk analysis are reported in Table 6, below.  The chronic dietary (food and drinking water) exposure to metconazole is below HED's level of concern for the general U.S. population and all population subgroups.  The chronic dietary (food and drinking water) exposure estimates are 6.6% of the cPAD for the general U.S. population and 14% of the cPAD for children 1-2 years old, the most highly exposed population subgroup.     


 Table 6.  Summary of Dietary (Food and Drinking Water) Exposure and Risk for Metconazole.
                              Population Subgroup
                                 Acute Dietary
                              (95[th] Percentile)
                                Chronic Dietary
                                     Cancer
                                        
                          Dietary Exposure (mg/kg/day)
                                    % aPAD*
                                Dietary Exposure
                                  (mg/kg/day)
                                    % cPAD*
                                Dietary Exposure
                                  (mg/kg/day)
                                      Risk
 General U.S. Population
                                       NA
                                       NA
                                    0.002653
                                      6.6
                                      N/A
                                      N/A
 All Infants (<1 year old)
 
 
                                    0.004963
                                       12
                                        
                                        
 Children 1-2 years old*
 
 
                                    0.005391
                                       14
 
 
 Children 3-5 years old
 
 
                                    0.004749
                                       12
 
 
 Children 6-12 years old
 
 
                                    0.003241
                                      8.1
 
 
 Youth 13-19 years old
 
 
                                    0.002045
                                      5.1
 
 
 Adults 20-49 years old
 
 
                                    0.002549
                                      6.4
 
 
 Adults 50-99 years old
 
 
                                    0.002166
                                      5.4
 
 
 Females 13-49 years old*
                                    0.005500
                                      4.6
                                    0.002179
                                      5.4
 
 
*The subpopulations with the highest risk estimates are bolded. 

 VIII.  Characterization of Inputs/Outputs
 
Unrefined acute and chronic dietary exposure assessments were conducted.  Except for cereal grains and livestock commodities, the residue levels used in the assessment were the established or recommended tolerance levels.  For cereal grains and livestock commodities, maximum residue values for the metabolites from field trials were added to the metconazole tolerance levels.  It was assumed that 100% of the crops were treated.  Default and empirical processing factors were used, as available.  EDWCs based on modeling were provided by EFED and incorporated directly into the acute and chronic dietary assessments.  Although not needed at this time, HED could refine the exposure and risk estimates with the following information: 1) projected market share/percent crop treated data;  2) anticipated residue data; and 3) monitoring data.


IX.		Conclusions

Acute and chronic dietary (food and drinking water) exposure assessments were conducted for the proposed/established uses.  The acute dietary (food and drinking water) exposure to metconazole is below HED's level of concern for females 13-49 years old, the only population subgroup of concern.  The chronic dietary (food and drinking water) exposure to metconazole is below HED's level of concern for the general U.S. population and all population subgroups.
 
 X.		List of Attachments
 
1.	Acute Food plus Water Residue Input File.
2.	Acute Results File.
3.	Chronic Food plus Water Residue Input File.
4.	Chronic Results File.

Attachment 1.  Acute Food plus Water Residue Input File

Filename: C:\Users\ndodd\Documents\DEEM Version 3.16\Metconazole\MetconazoleAcuteSunflower.R08
Chemical: Metconazole
RfD(Chronic): .04 mg/kg bw/day  NOEL(Chronic): 4.3 mg/kg bw/day
RfD(Acute): .12 mg/kg bw/day  NOEL(Acute):  12 mg/kg bw/day
Date created/last modified: 11-07-2014/15:57:58       Program ver. 3.16, 03-08-d
Comment:  
-----------------------------------------------------------------------------------
   EPA     Crop                                   Def Res     Adj.Factors   Comment
   Code     Grp  Commodity Name                    (ppm)       #1    #2   
---------- ---- -------------------------------  ----------  ------ ------  -------
0101052000 1A   Beet, sugar                        0.070000   1.000  1.000  
0101052001 1A   Beet, sugar-babyfood               0.070000   1.000  1.000  
0101053000 1A   Beet, sugar, molasses              0.080000   1.000  1.000  D34816
            Full comment: D348168
0101053001 1A   Beet, sugar, molasses-babyfood     0.080000   1.000  1.000  
0103015000 1CD  Arrowroot, flour                   0.040000   1.000  1.000  
0103015001 1CD  Arrowroot, flour-babyfood          0.040000   1.000  1.000  
0103017000 1CD  Artichoke, Jerusalem               0.040000   1.000  1.000  
0103082000 1CD  Cassava                            0.040000   1.000  1.000  
0103082001 1CD  Cassava-babyfood                   0.040000   1.000  1.000  
0103139000 1CD  Dasheen, corm                      0.040000   1.000  1.000  
0103166000 1CD  Ginger                             0.040000   1.000  1.000  
0103166001 1CD  Ginger-babyfood                    0.040000   1.000  1.000  
0103167000 1CD  Ginger, dried                      0.040000   1.000  1.000  
0103296000 1C   Potato, chips                      0.040000   1.000  1.000  D38099
            Full comment: D380990
0103297000 1C   Potato, dry (granules/ flakes)     0.040000   1.000  1.000  D38099
            Full comment: D380990
0103297001 1C   Potato, dry (granules/ flakes)-b   0.040000   1.000  1.000  
0103298000 1C   Potato, flour                      0.040000   1.000  1.000  
0103298001 1C   Potato, flour-babyfood             0.040000   1.000  1.000  
0103299000 1C   Potato, tuber, w/peel              0.040000   1.000  1.000  
0103299001 1C   Potato, tuber, w/peel-babyfood     0.040000   1.000  1.000  
0103300000 1C   Potato, tuber, w/o peel            0.040000   1.000  1.000  
0103300001 1C   Potato, tuber, w/o peel-babyfood   0.040000   1.000  1.000  
0103366000 1CD  Sweet potato                       0.040000   1.000  1.000  
0103366001 1CD  Sweet potato-babyfood              0.040000   1.000  1.000  
0103371000 1CD  Tanier, corm                       0.040000   1.000  1.000  
0103387000 1CD  Turmeric                           0.040000   1.000  1.000  
0103406000 1CD  Yam, true                          0.040000   1.000  1.000  
0103407000 1CD  Yam bean                           0.040000   1.000  1.000  
0600347000 6    Soybean, seed                      0.050000   1.000  1.000  
0600349000 6    Soybean, soy milk                  0.050000   1.000  1.000  
0600349001 6    Soybean, soy milk-babyfood or in   0.050000   1.000  1.000  
0600350000 6    Soybean, oil                       0.050000   1.000  1.000  D34816
            Full comment: D348168
0600350001 6    Soybean, oil-babyfood              0.050000   1.000  1.000  
0601349500 6AB  Soybean, vegetable                 0.050000   1.000  1.000  
0603030000 6C   Bean, black, seed                  0.150000   1.000  1.000  
0603032000 6C   Bean, broad, seed                  0.150000   1.000  1.000  
0603034000 6C   Bean, cowpea, seed                 0.150000   1.000  1.000  
0603035000 6C   Bean,  great northern, seed        0.150000   1.000  1.000  
0603036000 6C   Bean, kidney, seed                 0.150000   1.000  1.000  
0603038000 6C   Bean, lima, seed                   0.150000   1.000  1.000  
0603039000 6C   Bean, mung, seed                   0.150000   1.000  1.000  
0603040000 6C   Bean, navy, seed                   0.150000   1.000  1.000  
0603041000 6C   Bean, pink, seed                   0.150000   1.000  1.000  
0603042000 6C   Bean, pinto, seed                  0.150000   1.000  1.000  
0603098000 6C   Chickpea, seed                     0.150000   1.000  1.000  
0603098001 6C   Chickpea, seed-babyfood            0.150000   1.000  1.000  
0603099000 6C   Chickpea, flour                    0.150000   1.000  1.000  
0603182000 6C   Guar, seed                         0.150000   1.000  1.000  
0603182001 6C   Guar, seed-babyfood                0.150000   1.000  1.000  
0603203000 6C   Lentil, seed                       0.150000   1.000  1.000  
0603256000 6C   Pea, dry                           0.150000   1.000  1.000  
0603256001 6C   Pea, dry-babyfood                  0.150000   1.000  1.000  
0603258000 6C   Pea, pigeon, seed                  0.150000   1.000  1.000  
0603348000 6C   Soybean, flour                     0.050000   1.000  1.000  
0603348001 6C   Soybean, flour-babyfood            0.050000   1.000  1.000  
1201090000 12A  Cherry                             0.200000   1.000  1.000  
1201090001 12A  Cherry-babyfood                    0.200000   1.000  1.000  
1201091000 12A  Cherry, juice                      0.200000   1.500  1.000  
1201091001 12A  Cherry, juice-babyfood             0.200000   1.500  1.000  
1202012000 12B  Apricot                            0.200000   1.000  1.000  
1202012001 12B  Apricot-babyfood                   0.200000   1.000  1.000  
1202013000 12B  Apricot, dried                     0.200000   6.000  1.000  
1202014000 12B  Apricot, juice                     0.200000   1.000  1.000  
1202014001 12B  Apricot, juice-babyfood            0.200000   1.000  1.000  
1202230000 12B  Nectarine                          0.200000   1.000  1.000  
1202260000 12B  Peach                              0.200000   1.000  1.000  
1202260001 12B  Peach-babyfood                     0.200000   1.000  1.000  
1202261000 12B  Peach, dried                       0.200000   7.000  1.000  
1202261001 12B  Peach, dried-babyfood              0.200000   7.000  1.000  
1202262000 12B  Peach, juice                       0.200000   1.000  1.000  
1202262001 12B  Peach, juice-babyfood              0.200000   1.000  1.000  
1203285000 12C  Plum                               0.200000   1.000  1.000  
1203285001 12C  Plum-babyfood                      0.200000   1.000  1.000  
1203286000 12C  Plum, prune, fresh                 0.200000   1.000  1.000  
1203286001 12C  Plum, prune, fresh-babyfood        0.200000   1.000  1.000  
1203287000 12C  Plum, prune, dried                 0.200000   1.000  1.000  D34816
            Full comment: D348168
1203287001 12C  Plum, prune, dried-babyfood        0.200000   1.000  1.000  
1203288000 12C  Plum, prune, juice                 0.200000   1.400  1.000  
1203288001 12C  Plum, prune, juice-babyfood        0.200000   1.400  1.000  
1302057000 13B  Blueberry                          0.400000   1.000  1.000  
1302057001 13B  Blueberry-babyfood                 0.400000   1.000  1.000  
1302136000 13B  Currant                            0.400000   1.000  1.000  
1302137000 13B  Currant, dried                     0.400000   1.000  1.000  
1302149000 13B  Elderberry                         0.400000   1.000  1.000  
1302174000 13B  Gooseberry                         0.400000   1.000  1.000  
1302191000 13B  Huckleberry                        0.400000   1.000  1.000  
1307130000 13G  Cranberry                          0.400000   1.000  1.000  
1307130001 13G  Cranberry-babyfood                 0.400000   1.000  1.000  
1307131000 13G  Cranberry, dried                   0.400000   1.000  1.000  
1307132000 13G  Cranberry, juice                   0.400000   1.100  1.000  
1307132001 13G  Cranberry, juice-babyfood          0.400000   1.100  1.000  
1400003000 14   Almond                             0.040000   1.000  1.000  
1400003001 14   Almond-babyfood                    0.040000   1.000  1.000  
1400004000 14   Almond, oil                        0.040000   1.000  1.000  
1400004001 14   Almond, oil-babyfood               0.040000   1.000  1.000  
1400059000 14   Brazil nut                         0.040000   1.000  1.000  
1400068000 14   Butternut                          0.040000   1.000  1.000  
1400081000 14   Cashew                             0.040000   1.000  1.000  
1400092000 14   Chestnut                           0.040000   1.000  1.000  
1400155000 14   Hazelnut                           0.040000   1.000  1.000  
1400156000 14   Hazelnut, oil                      0.040000   1.000  1.000  
1400185000 14   Hickory nut                        0.040000   1.000  1.000  
1400213000 14   Macadamia nut                      0.040000   1.000  1.000  
1400269000 14   Pecan                              0.040000   1.000  1.000  
1400278000 14   Pine nut                           0.040000   1.000  1.000  
1400282000 14   Pistachio                          0.040000   1.000  1.000  
1400391000 14   Walnut                             0.040000   1.000  1.000  
1500025000 15   Barley, pearled barley             2.830000   1.000  1.000  
1500025001 15   Barley, pearled barley-babyfood    2.830000   1.000  1.000  
1500026000 15   Barley, flour                      2.830000   1.000  1.000  
1500026001 15   Barley, flour-babyfood             2.830000   1.000  1.000  
1500027000 15   Barley, bran                       2.830000   2.000  1.000  
1500120000 15   Corn, field, flour                 0.030000   1.000  1.000  
1500120001 15   Corn, field, flour-babyfood        0.030000   1.000  1.000  
1500121000 15   Corn, field, meal                  0.030000   1.000  1.000  
1500121001 15   Corn, field, meal-babyfood         0.030000   1.000  1.000  
1500122000 15   Corn, field, bran                  0.030000   1.000  1.000  
1500123000 15   Corn, field, starch                0.030000   1.000  1.000  
1500123001 15   Corn, field, starch-babyfood       0.030000   1.000  1.000  
1500124000 15   Corn, field, syrup                 0.030000   1.500  1.000  
1500124001 15   Corn, field, syrup-babyfood        0.030000   1.500  1.000  
1500125000 15   Corn, field, oil                   0.030000   1.000  1.000  
1500125001 15   Corn, field, oil-babyfood          0.030000   1.000  1.000  
1500126000 15   Corn, pop                          0.030000   1.000  1.000  
1500127000 15   Corn, sweet                        0.020000   1.000  1.000  
1500127001 15   Corn, sweet-babyfood               0.020000   1.000  1.000  
1500231000 15   Oat, bran                          1.340000   2.000  1.000  
1500232000 15   Oat, flour                         1.340000   1.000  1.000  
1500232001 15   Oat, flour-babyfood                1.340000   1.000  1.000  
1500233000 15   Oat, groats/rolled oats            1.340000   1.000  1.000  
1500233001 15   Oat, groats/rolled oats-babyfood   1.340000   1.000  1.000  
1500328000 15   Rye, grain                         0.290000   1.000  1.000  
1500329000 15   Rye, flour                         0.290000   1.000  1.000  
1500401000 15   Wheat, grain                       0.180000   1.000  1.000  
1500401001 15   Wheat, grain-babyfood              0.180000   1.000  1.000  
1500402000 15   Wheat, flour                       0.180000   1.000  1.000  D34816
            Full comment: D348168
1500402001 15   Wheat, flour-babyfood              0.180000   1.000  1.000  
1500403000 15   Wheat, germ                        0.180000   1.000  1.000  D34816
            Full comment: D348168
1500404000 15   Wheat, bran                        0.180000   2.000  1.000  D34816
            Full comment: D348168, MRID 46902231
2001163000 20A  Flax seed, oil                     0.080000   1.000  1.000  
2001319000 20A  Rapeseed, oil                      0.080000   1.000  1.000  D42362
            Full comment: D423622
2001319001 20A  Rapeseed, oil-babyfood             0.080000   1.000  1.000  
2001336000 20A  Sesame, seed                       0.080000   1.000  1.000  
2001336001 20A  Sesame, seed-babyfood              0.080000   1.000  1.000  
2001337000 20A  Sesame, oil                        0.080000   1.000  1.000  D42362
            Full comment: D423622
2001337001 20A  Sesame, oil-babyfood               0.080000   1.000  1.000  
2002330000 20B  Safflower, oil                     0.700000   1.000  1.000  
2002330001 20B  Safflower, oil-babyfood            0.700000   1.000  1.000  
2002364000 20B  Sunflower, seed                    0.700000   1.000  1.000  
2002365000 20B  Sunflower, oil                     0.700000   1.000  1.000  D42362
            Full comment: D423622
2002365001 20B  Sunflower, oil-babyfood            0.700000   1.000  1.000  
2003128000 20C  Cottonseed, oil                    0.250000   1.000  1.000  
2003128001 20C  Cottonseed, oil-babyfood           0.250000   1.000  1.000  
3100046000 31   Beef, meat byproducts              0.100000   1.000  1.000  
3100046001 31   Beef, meat byproducts-babyfood     0.100000   1.000  1.000  
3100048000 31   Beef, kidney                       0.100000   1.000  1.000  
3100049000 31   Beef, liver                        0.100000   1.000  1.000  
3100049001 31   Beef, liver-babyfood               0.100000   1.000  1.000  
3200170000 32   Goat, meat byproducts              0.100000   1.000  1.000  
3200172000 32   Goat, kidney                       0.100000   1.000  1.000  
3200173000 32   Goat, liver                        0.100000   1.000  1.000  
3500340000 35   Sheep, meat byproducts             0.100000   1.000  1.000  
3500342000 35   Sheep, kidney                      0.100000   1.000  1.000  
3500343000 35   Sheep, liver                       0.100000   1.000  1.000  
7000145000 70   Egg, whole                         0.100000   1.000  1.000  
7000145001 70   Egg, whole-babyfood                0.100000   1.000  1.000  
7000146000 70   Egg, white                         0.100000   1.000  1.000  
7000146001 70   Egg, white (solids)-babyfood       0.100000   1.000  1.000  
7000147000 70   Egg, yolk                          0.100000   1.000  1.000  
7000147001 70   Egg, yolk-babyfood                 0.100000   1.000  1.000  
8601000000 86A  Water, direct, all sources         0.051800   1.000  1.000  
8602000000 86B  Water, indirect, all sources       0.051800   1.000  1.000  
9500023000 O    Banana                             0.100000   1.000  1.000  
9500023001 O    Banana-babyfood                    0.100000   1.000  1.000  
9500024000 O    Banana, dried                      0.100000   3.900  1.000  
9500024001 O    Banana, dried-babyfood             0.100000   3.900  1.000  
9500263000 O    Peanut                             0.040000   1.000  1.000  
9500264000 O    Peanut, butter                     0.050000   1.890  1.000  
9500265000 O    Peanut, oil                        0.050000   1.000  1.000  D34816
            Full comment: D348168
9500283000 O    Plantain                           0.100000   1.000  1.000  
9500284000 O    Plantain, dried                    0.100000   3.900  1.000  
9500362000 O    Sugarcane, sugar                   1.600000   1.000  1.000  D34816
            Full comment: D348168
9500362001 O    Sugarcane, sugar-babyfood          1.600000   1.000  1.000  
9500363000 O    Sugarcane, molasses                3.200000   1.000  1.000  Sectio
            Full comment: Section 18 tolerance =1.6 x 2x 
9500363001 O    Sugarcane, molasses-babyfood       3.200000   1.000  1.000  

Attachment 2.  Acute Results File


US EPA                                                      Ver. 3.18, 03-08-d
DEEM-FCID ACUTE Analysis for METCONAZOLE                 NHANES 2003-2008 2-Day
Residue file: MetconazoleAcuteSunflower.R08           Adjustment factor #2 used.
Analysis Date: 11-07-2014/16:13:21    Residue file dated: 11-07-2014/15:57:58
NOEL (Acute) =  12.000000 mg/kg body-wt/day
RAC/FF intake summed over 24 hours
Run Comment: " "
===============================================================================

Summary calculations--per capita:

---   95th Percentile----   ---   99th Percentile----     ---99.9th Percentile----
 Exposure  % aRfD     MOE    Exposure  % aRfD     MOE    Exposure  % aRfD     MOE  
---------- ------- -------- ---------- ------- -------- ---------- ------- --------
Female 13-49:
  0.005500    4.58    2181    0.008947    7.46    1341    0.015703   13.09     764  























Attachment 3.  Chronic Food plus Water Residue Input File

Filename: C:\Users\ndodd\Documents\DEEM Version 3.16\Metconazole\MetconazoleChronicSunflower.R08
Chemical: Metconazole
RfD(Chronic): .04 mg/kg bw/day  NOEL(Chronic): 4.3 mg/kg bw/day
RfD(Acute): .12 mg/kg bw/day  NOEL(Acute):  12 mg/kg bw/day
Date created/last modified: 11-07-2014/15:59:15       Program ver. 3.16, 03-08-d
Comment:  
-----------------------------------------------------------------------------------
   EPA     Crop                                   Def Res     Adj.Factors   Comment
   Code     Grp  Commodity Name                    (ppm)       #1    #2   
---------- ---- -------------------------------  ----------  ------ ------  -------
0101052000 1A   Beet, sugar                        0.070000   1.000  1.000  
0101052001 1A   Beet, sugar-babyfood               0.070000   1.000  1.000  
0101053000 1A   Beet, sugar, molasses              0.080000   1.000  1.000  D34816
            Full comment: D348168
0101053001 1A   Beet, sugar, molasses-babyfood     0.080000   1.000  1.000  
0103015000 1CD  Arrowroot, flour                   0.040000   1.000  1.000  
0103015001 1CD  Arrowroot, flour-babyfood          0.040000   1.000  1.000  
0103017000 1CD  Artichoke, Jerusalem               0.040000   1.000  1.000  
0103082000 1CD  Cassava                            0.040000   1.000  1.000  
0103082001 1CD  Cassava-babyfood                   0.040000   1.000  1.000  
0103139000 1CD  Dasheen, corm                      0.040000   1.000  1.000  
0103166000 1CD  Ginger                             0.040000   1.000  1.000  
0103166001 1CD  Ginger-babyfood                    0.040000   1.000  1.000  
0103167000 1CD  Ginger, dried                      0.040000   1.000  1.000  
0103296000 1C   Potato, chips                      0.040000   1.000  1.000  D38099
            Full comment: D380990
0103297000 1C   Potato, dry (granules/ flakes)     0.040000   1.000  1.000  D38099
            Full comment: D380990
0103297001 1C   Potato, dry (granules/ flakes)-b   0.040000   1.000  1.000  
0103298000 1C   Potato, flour                      0.040000   1.000  1.000  
0103298001 1C   Potato, flour-babyfood             0.040000   1.000  1.000  
0103299000 1C   Potato, tuber, w/peel              0.040000   1.000  1.000  
0103299001 1C   Potato, tuber, w/peel-babyfood     0.040000   1.000  1.000  
0103300000 1C   Potato, tuber, w/o peel            0.040000   1.000  1.000  
0103300001 1C   Potato, tuber, w/o peel-babyfood   0.040000   1.000  1.000  
0103366000 1CD  Sweet potato                       0.040000   1.000  1.000  
0103366001 1CD  Sweet potato-babyfood              0.040000   1.000  1.000  
0103371000 1CD  Tanier, corm                       0.040000   1.000  1.000  
0103387000 1CD  Turmeric                           0.040000   1.000  1.000  
0103406000 1CD  Yam, true                          0.040000   1.000  1.000  
0103407000 1CD  Yam bean                           0.040000   1.000  1.000  
0600347000 6    Soybean, seed                      0.050000   1.000  1.000  
0600349000 6    Soybean, soy milk                  0.050000   1.000  1.000  
0600349001 6    Soybean, soy milk-babyfood or in   0.050000   1.000  1.000  
0600350000 6    Soybean, oil                       0.050000   1.000  1.000  D34816
            Full comment: D348168
0600350001 6    Soybean, oil-babyfood              0.050000   1.000  1.000  
0601349500 6AB  Soybean, vegetable                 0.050000   1.000  1.000  
0603030000 6C   Bean, black, seed                  0.150000   1.000  1.000  
0603032000 6C   Bean, broad, seed                  0.150000   1.000  1.000  
0603034000 6C   Bean, cowpea, seed                 0.150000   1.000  1.000  
0603035000 6C   Bean,  great northern, seed        0.150000   1.000  1.000  
0603036000 6C   Bean, kidney, seed                 0.150000   1.000  1.000  
0603038000 6C   Bean, lima, seed                   0.150000   1.000  1.000  
0603039000 6C   Bean, mung, seed                   0.150000   1.000  1.000  
0603040000 6C   Bean, navy, seed                   0.150000   1.000  1.000  
0603041000 6C   Bean, pink, seed                   0.150000   1.000  1.000  
0603042000 6C   Bean, pinto, seed                  0.150000   1.000  1.000  
0603098000 6C   Chickpea, seed                     0.150000   1.000  1.000  
0603098001 6C   Chickpea, seed-babyfood            0.150000   1.000  1.000  
0603099000 6C   Chickpea, flour                    0.150000   1.000  1.000  
0603182000 6C   Guar, seed                         0.150000   1.000  1.000  
0603182001 6C   Guar, seed-babyfood                0.150000   1.000  1.000  
0603203000 6C   Lentil, seed                       0.150000   1.000  1.000  
0603256000 6C   Pea, dry                           0.150000   1.000  1.000  
0603256001 6C   Pea, dry-babyfood                  0.150000   1.000  1.000  
0603258000 6C   Pea, pigeon, seed                  0.150000   1.000  1.000  
0603348000 6C   Soybean, flour                     0.050000   1.000  1.000  
0603348001 6C   Soybean, flour-babyfood            0.050000   1.000  1.000  
1201090000 12A  Cherry                             0.200000   1.000  1.000  
1201090001 12A  Cherry-babyfood                    0.200000   1.000  1.000  
1201091000 12A  Cherry, juice                      0.200000   1.500  1.000  
1201091001 12A  Cherry, juice-babyfood             0.200000   1.500  1.000  
1202012000 12B  Apricot                            0.200000   1.000  1.000  
1202012001 12B  Apricot-babyfood                   0.200000   1.000  1.000  
1202013000 12B  Apricot, dried                     0.200000   6.000  1.000  
1202014000 12B  Apricot, juice                     0.200000   1.000  1.000  
1202014001 12B  Apricot, juice-babyfood            0.200000   1.000  1.000  
1202230000 12B  Nectarine                          0.200000   1.000  1.000  
1202260000 12B  Peach                              0.200000   1.000  1.000  
1202260001 12B  Peach-babyfood                     0.200000   1.000  1.000  
1202261000 12B  Peach, dried                       0.200000   7.000  1.000  
1202261001 12B  Peach, dried-babyfood              0.200000   7.000  1.000  
1202262000 12B  Peach, juice                       0.200000   1.000  1.000  
1202262001 12B  Peach, juice-babyfood              0.200000   1.000  1.000  
1203285000 12C  Plum                               0.200000   1.000  1.000  
1203285001 12C  Plum-babyfood                      0.200000   1.000  1.000  
1203286000 12C  Plum, prune, fresh                 0.200000   1.000  1.000  
1203286001 12C  Plum, prune, fresh-babyfood        0.200000   1.000  1.000  
1203287000 12C  Plum, prune, dried                 0.200000   1.000  1.000  D34816
            Full comment: D348168
1203287001 12C  Plum, prune, dried-babyfood        0.200000   1.000  1.000  
1203288000 12C  Plum, prune, juice                 0.200000   1.400  1.000  
1203288001 12C  Plum, prune, juice-babyfood        0.200000   1.400  1.000  
1302057000 13B  Blueberry                          0.400000   1.000  1.000  
1302057001 13B  Blueberry-babyfood                 0.400000   1.000  1.000  
1302136000 13B  Currant                            0.400000   1.000  1.000  
1302137000 13B  Currant, dried                     0.400000   1.000  1.000  
1302149000 13B  Elderberry                         0.400000   1.000  1.000  
1302174000 13B  Gooseberry                         0.400000   1.000  1.000  
1302191000 13B  Huckleberry                        0.400000   1.000  1.000  
1307130000 13G  Cranberry                          0.400000   1.000  1.000  
1307130001 13G  Cranberry-babyfood                 0.400000   1.000  1.000  
1307131000 13G  Cranberry, dried                   0.400000   1.000  1.000  
1307132000 13G  Cranberry, juice                   0.400000   1.100  1.000  
1307132001 13G  Cranberry, juice-babyfood          0.400000   1.100  1.000  
1400003000 14   Almond                             0.040000   1.000  1.000  
1400003001 14   Almond-babyfood                    0.040000   1.000  1.000  
1400004000 14   Almond, oil                        0.040000   1.000  1.000  
1400004001 14   Almond, oil-babyfood               0.040000   1.000  1.000  
1400059000 14   Brazil nut                         0.040000   1.000  1.000  
1400068000 14   Butternut                          0.040000   1.000  1.000  
1400081000 14   Cashew                             0.040000   1.000  1.000  
1400092000 14   Chestnut                           0.040000   1.000  1.000  
1400155000 14   Hazelnut                           0.040000   1.000  1.000  
1400156000 14   Hazelnut, oil                      0.040000   1.000  1.000  
1400185000 14   Hickory nut                        0.040000   1.000  1.000  
1400213000 14   Macadamia nut                      0.040000   1.000  1.000  
1400269000 14   Pecan                              0.040000   1.000  1.000  
1400278000 14   Pine nut                           0.040000   1.000  1.000  
1400282000 14   Pistachio                          0.040000   1.000  1.000  
1400391000 14   Walnut                             0.040000   1.000  1.000  
1500025000 15   Barley, pearled barley             2.830000   1.000  1.000  
1500025001 15   Barley, pearled barley-babyfood    2.830000   1.000  1.000  
1500026000 15   Barley, flour                      2.830000   1.000  1.000  
1500026001 15   Barley, flour-babyfood             2.830000   1.000  1.000  
1500027000 15   Barley, bran                       2.830000   2.000  1.000  
1500120000 15   Corn, field, flour                 0.030000   1.000  1.000  
1500120001 15   Corn, field, flour-babyfood        0.030000   1.000  1.000  
1500121000 15   Corn, field, meal                  0.030000   1.000  1.000  
1500121001 15   Corn, field, meal-babyfood         0.030000   1.000  1.000  
1500122000 15   Corn, field, bran                  0.030000   1.000  1.000  
1500123000 15   Corn, field, starch                0.030000   1.000  1.000  
1500123001 15   Corn, field, starch-babyfood       0.030000   1.000  1.000  
1500124000 15   Corn, field, syrup                 0.030000   1.500  1.000  
1500124001 15   Corn, field, syrup-babyfood        0.030000   1.500  1.000  
1500125000 15   Corn, field, oil                   0.030000   1.000  1.000  
1500125001 15   Corn, field, oil-babyfood          0.030000   1.000  1.000  
1500126000 15   Corn, pop                          0.030000   1.000  1.000  
1500127000 15   Corn, sweet                        0.020000   1.000  1.000  
1500127001 15   Corn, sweet-babyfood               0.020000   1.000  1.000  
1500231000 15   Oat, bran                          1.340000   2.000  1.000  
1500232000 15   Oat, flour                         1.340000   1.000  1.000  
1500232001 15   Oat, flour-babyfood                1.340000   1.000  1.000  
1500233000 15   Oat, groats/rolled oats            1.340000   1.000  1.000  
1500233001 15   Oat, groats/rolled oats-babyfood   1.340000   1.000  1.000  
1500328000 15   Rye, grain                         0.290000   1.000  1.000  
1500329000 15   Rye, flour                         0.290000   1.000  1.000  
1500401000 15   Wheat, grain                       0.180000   1.000  1.000  
1500401001 15   Wheat, grain-babyfood              0.180000   1.000  1.000  
1500402000 15   Wheat, flour                       0.180000   1.000  1.000  D34816
            Full comment: D348168
1500402001 15   Wheat, flour-babyfood              0.180000   1.000  1.000  
1500403000 15   Wheat, germ                        0.180000   1.000  1.000  D34816
            Full comment: D348168
1500404000 15   Wheat, bran                        0.180000   2.000  1.000  D34816
            Full comment: D348168; MRID 46902231
2001163000 20A  Flax seed, oil                     0.080000   1.000  1.000  
2001319000 20A  Rapeseed, oil                      0.080000   1.000  1.000  D42362
            Full comment: D423622
2001319001 20A  Rapeseed, oil-babyfood             0.080000   1.000  1.000  
2001336000 20A  Sesame, seed                       0.080000   1.000  1.000  
2001336001 20A  Sesame, seed-babyfood              0.080000   1.000  1.000  
2001337000 20A  Sesame, oil                        0.080000   1.000  1.000  D42362
            Full comment: D423622
2001337001 20A  Sesame, oil-babyfood               0.080000   1.000  1.000  
2002330000 20B  Safflower, oil                     0.700000   1.000  1.000  
2002330001 20B  Safflower, oil-babyfood            0.700000   1.000  1.000  
2002364000 20B  Sunflower, seed                    0.700000   1.000  1.000  
2002365000 20B  Sunflower, oil                     0.700000   1.000  1.000  D42362
            Full comment: D423622
2002365001 20B  Sunflower, oil-babyfood            0.700000   1.000  1.000  
2003128000 20C  Cottonseed, oil                    0.250000   1.000  1.000  
2003128001 20C  Cottonseed, oil-babyfood           0.250000   1.000  1.000  
3100046000 31   Beef, meat byproducts              0.100000   1.000  1.000  
3100046001 31   Beef, meat byproducts-babyfood     0.100000   1.000  1.000  
3100048000 31   Beef, kidney                       0.100000   1.000  1.000  
3100049000 31   Beef, liver                        0.100000   1.000  1.000  
3100049001 31   Beef, liver-babyfood               0.100000   1.000  1.000  
3200170000 32   Goat, meat byproducts              0.100000   1.000  1.000  
3200172000 32   Goat, kidney                       0.100000   1.000  1.000  
3200173000 32   Goat, liver                        0.100000   1.000  1.000  
3500340000 35   Sheep, meat byproducts             0.100000   1.000  1.000  
3500342000 35   Sheep, kidney                      0.100000   1.000  1.000  
3500343000 35   Sheep, liver                       0.100000   1.000  1.000  
7000145000 70   Egg, whole                         0.100000   1.000  1.000  
7000145001 70   Egg, whole-babyfood                0.100000   1.000  1.000  
7000146000 70   Egg, white                         0.100000   1.000  1.000  
7000146001 70   Egg, white (solids)-babyfood       0.100000   1.000  1.000  
7000147000 70   Egg, yolk                          0.100000   1.000  1.000  
7000147001 70   Egg, yolk-babyfood                 0.100000   1.000  1.000  
8601000000 86A  Water, direct, all sources         0.043900   1.000  1.000  
8602000000 86B  Water, indirect, all sources       0.043900   1.000  1.000  
9500023000 O    Banana                             0.100000   1.000  1.000  
9500023001 O    Banana-babyfood                    0.100000   1.000  1.000  
9500024000 O    Banana, dried                      0.100000   3.900  1.000  
9500024001 O    Banana, dried-babyfood             0.100000   3.900  1.000  
9500263000 O    Peanut                             0.040000   1.000  1.000  
9500264000 O    Peanut, butter                     0.050000   1.890  1.000  
9500265000 O    Peanut, oil                        0.050000   1.000  1.000  D34816
            Full comment: D348168
9500283000 O    Plantain                           0.100000   1.000  1.000  
9500284000 O    Plantain, dried                    0.100000   3.900  1.000  
9500362000 O    Sugarcane, sugar                   1.600000   1.000  1.000  D34816
            Full comment: D348168
9500362001 O    Sugarcane, sugar-babyfood          1.600000   1.000  1.000  
9500363000 O    Sugarcane, molasses                3.200000   1.000  1.000  Sectio
            Full comment: Section 18 tolerance =1.6 x 2x 
9500363001 O    Sugarcane, molasses-babyfood       3.200000   1.000  1.000  

Attachment 4:  Chronic Results File

US EPA                                                          Ver. 3.16, 03-08-d
DEEM-FCID Chronic analysis for METCONAZOLE                 NHANES 2003-2008 2-day
Residue file name: C:\Users\ndodd\Documents\DEEM Version 3.16\Metconazole\MetconazoleChronicSunflower.R08
                                                     Adjustment factor #2 used.
Analysis Date 11-07-2014/16:15:22     Residue file dated: 11-07-2014/15:59:15
Reference dose (RfD, Chronic) = .04 mg/kg bw/day
===============================================================================
                    Total exposure by population subgroup
-------------------------------------------------------------------------------

                                                    Total Exposure
                                         -----------------------------------
          Population                         mg/kg             Percent of   
           Subgroup                       body wt/day             Rfd       
--------------------------------------   -------------       ----------------
Total US Population                         0.002653                 6.6%
Hispanic                                    0.002641                 6.6%
Non-Hisp-White                              0.002701                 6.8%
Non-Hisp-Black                              0.002353                 5.9%
Non-Hisp-Other                              0.002747                 6.9%
Nursing Infants                             0.002351                 5.9%
Non-Nursing Infants                         0.006129                15.3%
Female 13+ PREG                             0.002123                 5.3%
Children 1-6                                0.004914                12.3%
Children 7-12                               0.003045                 7.6%
Male 13-19                                  0.002133                 5.3%
Female 13-19/NP                             0.001966                 4.9%
Male 20+                                    0.002658                 6.6%
Female 20+/NP                               0.002149                 5.4%
Seniors 55+                                 0.002074                 5.2%
All Infants                                 0.004963                12.4%
Female 13-50                                0.002174                 5.4%
Children 1-2                                0.005391                13.5%
Children 3-5                                0.004749                11.9%
Children 6-12                               0.003241                 8.1%
Youth 13-19                                 0.002045                 5.1%
Adults 20-49                                0.002549                 6.4%
Adults 50-99                                0.002166                 5.4%
Female 13-49                                0.002179                 5.4%

-------------------------------------------------------------------------------


