                 UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
                         WASHINGTON, D.C. 20460      

                                                 	OFFICE OF CHEMICAL SAFETY AND
                                                                                            POLLUTION PREVENTION
	



MEMORANDUM

Date:		December 3, 2013

SUBJECT:	Chlorantraniliprole Chronic Dietary (Food and Drinking Water) Exposure and Risk Assessment for the Section (3) Registration Actions on Green Onion Subgroup 3-07b, and Peanut; and for the Requests to Update the Crop Groups of Stone Fruit, Tree Nut, and Spices; and to Shorten the Pre-Harvest Intervals for Papaya, Passionfruit, and Mayhaw.  
 
PC Code:  090100
DP Barcodes:  D416093
Decision Nos.:  476038, 477960,477964, 477967, 477972, 477952, 477965, 477970, 477957, 477963, 477954, 477966, 477971 
Registration Nos.:  352-729, 352-728, 352-730
Petition Nos.:  3E8170, 3F8158
Regulatory Action:  Section 3
Risk Assessment Type:  Dietary 
Case No.:  N/A
TXR No.:  N/A
CAS No.:  500008-45-7
MRID No.:  N/A
40 CFR:  §180.628


FROM:	Kristin Rury, Biologist
	Risk Assessment Branch III
	Health Effects Division (7509P)

THROUGH:	William Cutchin, Chemist
	Ideliz Encarnacion, Chemist
	Dietary Exposure Science Advisory Council (DESAC)

	And 
	
	Christine Olinger, Chief
	Risk Assessment Branch III
	Health Effects Division

TO:	Kristin Rury, Risk Assessor
	Risk Assessment Branch III
	Health Effects Division (7509P)
       
       And 
       
       Laura Nollen, Risk Manager
       Risk Integration Minor Use and Emergency Response Branch
       Division (7505P)
       
       And
       
       Jennifer Urbanski
       Insecticide/Rodenticide Branch (IRB)
       Registration Division (7505P)

Executive Summary

A chronic aggregate dietary food and drinking water exposure and risk assessment was conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM-FCID) Version 3.16, which uses food consumption data collected from 2003-2008 from the U.S. Department of Agriculture's (USDA's) National Health and Nutrition Examination Survey, What We Eat in America, (NHANES/WWEIA).  The analysis was conducted to support a human health risk assessment for (1) the proposed uses on green onion subgroup 3-07b, and peanut; (2) to update the existing stone fruit, tree nut, and spices crop groups to correspond with new crop group definitions; and (3) to shorten the pre-harvest intervals (PHIs) for papaya, passionfruit, and mayhaw.   This memo was reviewed by two peer reviewed of the Dietary Exposure Science Advisory Council (DESAC), per the DESAC Standard Operating Procedure (SOP) 2012.1.  

Acute Dietary Exposure Assessment: An acute dietary toxicity endpoint was not identified in the toxicity database for chlorantraniliprole; therefore, chlorantraniliprole does not pose an acute dietary risk and an acute dietary assessment is not required.  

Chronic Dietary Exposure Assessment: The chronic dietary (food and drinking water) exposure assessment for chlorantraniliprole assumed recommended and/or established tolerance-level residues, 100% crop treated (%CT), and used DEEM default processing factors.  Estimated drinking water concentrations (EDWCs) from the Environmental Fate and Effects Division (EFED) (207 ppb) were also included.  The results of the chronic analysis indicate that chronic dietary (food and drinking water) exposure and risk is not of concern to HED [i.e., <100% chronic population adjusted dose (cPAD)] for the general U.S. population and all population subgroups.  The resulting chronic dietary (food and drinking water) risk estimates utilized 2.3% of the cPAD for the general U.S. population and 6.7% for children 1-2 years old, the most highly exposed population subgroup.  

Cancer Dietary Exposure Assessment: Chlorantraniliprole is classified as "Not Likely to be Carcinogenic to Humans"; therefore, a cancer dietary risk assessment was not performed. 



I.  Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide.  For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose that HED has concluded will result in no unreasonable adverse health effects).  This dose is referred to as the population adjusted dose (PAD).  The PAD is equivalent to the point of departure (POD; no observed adverse effect level, NOAEL; lowest observed adverse effect level, LOAEL, e.g.) divided by the required uncertainty or safety factors.  

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD.  References that discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site:  "Available Information on Assessing Exposure from Pesticides, A User's Guide," 21-JUN-2000, web link:  http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf; or see SOP 99.6 (20-AUG-1999).

The most recent dietary risk assessment for chlorantraniliprole was conducted by Kristin Rury (05/29/2013, D411997).  

II.  Residue Information

Residues of Concern: Chlorantraniliprole is an insecticide that was developed by DuPont for control of lepidopteran pests.  The residue of concern for tolerance enforcement in plants, livestock, and water is the parent compound.  The residue of concern for risk assessment in plants is the parent compound.  The residues of concern for risk assessment in ruminants are the parent compound, IN-HXH44, and IN-K9T00.  The Risk Assessment team has decided that the residue of concern in poultry commodities for risk assessment will include the parent and the following metabolites:  IN-H2H20, IN-K7H29, IN-F9N04, and IN-GAZ70.  See Attachment 3 for names and structures.  Attachment 3 also shows the calculation of the poultry and egg residue levels for dietary risk assessment.  HED also recalculated the dietary burdens for beef and dairy cattle.  The resulting residue estimates were below the established tolerances for ruminants; therefore, tolerance-levels were used in the dietary risk assessment for cattle.

Established Tolerances: Permanent tolerances for chlorantraniliprole are currently established in/on a wide variety of crops (40 CFR §180.628).   

Recommended Tolerances: E.I. Du Pont de Nemours and Company (DuPont) has submitted an application for the use of chlorantraniliprole on peanuts (PP# 3F8158).  Additionally, the Interregional Research Project No. 4 (IR-4) submitted a petition (PP# 3E8170) to update the existing stone fruit, tree nut, and spices crop groups  to correspond with new crop group definitions, and a proposed shorter PHIs for the existing uses on papaya, passionfruit, and mayhaw.  The tolerance recommendations are outlined in Table 1.  

Residue Data used for Chronic Assessments: HED used tolerance-level residues for the proposed and registered crops and 100% crop treated was assumed for all commodities included in this assessment; therefore, this assessment is considered conservative.  Where processing data indicated a reduction (or no increase) in residue upon processing, the residue level of the raw agricultural commodity (RAC) was used without reduction, for example mint oil from spearmint.  Where processing data indicated an increase in residue in the processed commodity, a tolerance was established and used, e.g., raisins from grapes.  Where adequate processing data did not exist, DEEM default concentration factors were used if available.  DEEM default concentration factors were used for the following:  dried apple, apple juice, dried apricot, dried banana, dried beef meat, cherry juice, field corn syrup, cranberry juice, grape juice, grapefruit juice, lemon juice, lime juice, dried lychee, dried (dehydrated) bulb onion, orange juice, dried peach, dried pear, peanut butter, dried pineapple, pineapple juice, dried plantain, dried plum prune, plum juice, dried potato (flakes, granules), potato flour, tangerine juice, tomato paste, tomato puree, dried tomato, and tomato juice.  Table 1 lists all changes to tolerance values and HED recommended tolerances for the proposed crops used in the dietary assessment.  

Meat, Milk, Poultry and Eggs: There are no livestock feed items associated with the current petitions.  Therefore, the previous livestock dietary intake calculations and resulting tolerance recommendations remain unchanged.  

Table 1.  Tolerance Summary for Chlorantraniliprole.
Commodity
                     Established/Proposed Tolerance (ppm)
                        HED-Recommended Tolerance (ppm)
                                   Comments 
                        (correct commodity definition)
                                    Papaya
                                      2.0
                                      4.0
                                       
                                 Passionfruit
                                      2.0
                                      4.0
                                       
                                Peanut, nutmeat
                                     0.06
                                     0.06
                                       
                                  Peanut, hay
                                      90
                                      90
                         Translation from alfalfa hay
                         Onion, green, subgroup 3-07B
                                      3.0
                                      3.0
                                       
                              Spice subgroup 19B
                          14 established/40 proposed
                                      90
                                       
                            Nut, tree, group 14-12
                                     0.04
                                     0.02
                            Crop group conversion.
                         International harmonization.
                              Nut, tree, group 14
                                     0.04
                                    Remove
                         Replaced by crop group 14-12
                                   Pistachio
                                     0.04
                                    Remove
                         Replaced by crop group 14-12
                           Fruit, pome, group 11-10
                                      1.2
                                      1.2
                             Crop group conversion
                     Fruit, pome, group 11, except mayhaw
                                      1.2
                                    Remove
                         Replaced by crop group 11-10
                                    Mayhaw
                                      0.6
                                    Remove
                         Replaced by crop group 11-10
   Fruit, stone group 12-12, except cherry, Chickasaw plum, and damson plum
                                      4.0
                                      4.0
                             Crop group conversion
     Fruit, stone group 12, except cherry, Chickasaw plum, and damson plum
                                      4.0
                                    Remove
                         Replaced by crop group 12-12
                                   Crayfish
                                      8.0
                                     0.01
                                       

III.  Percent Crop Treated Information

The chronic dietary exposure assessment assumed 100% CT for all commodities. 
IV.  Drinking Water Data

The drinking water residues used in the dietary risk assessment were provided by EFED (C. Koper, 07/24/2013, D411577; and C. Koper, 09/23/2013, D414837) and incorporated directly into this dietary assessment.  Water residues were incorporated in the DEEM-FCID into the food categories "water, direct, all sources" and "water, indirect, all sources."  The EDWC for groundwater from the assessment evaluating the proposed uses is greater than the surface and groundwater estimates from the previous assessment.  Thus, the groundwater concentration of 207 ppb was used for this assessment.  This value of 207 ppb is the one in ten-year annual mean.

EDWCs for the chronic assessments were estimated using two EFED screening models: the Pesticide Root Zone Model (PRZM)-Exposure Analysis Modeling System (EXAMS) and PRZM-Ground Water (GW).  The recommended EDWCs for risk assessment are listed in Table 2.  The models and their descriptions are available at the EPA internet site: http://www.epa.gov/oppefed1/models/water/.  

Table 2.	Summary of Estimated Surface Water and Groundwater Concentrations (EDWCs) for Chlorantraniliprole Used on Cranberries.

                          Surface Water Conc., ppb a
                           Groundwater Conc., ppb b
Acute
                                     55.30
                                      207
Chronic (non-cancer, 1 in 10 year annual average)
                                     39.87
                                       
Chronic (cancer, 30-year annual average)
                                     39.87
                                       
[a] Pesticide Root Zone Model (PRZM v3.12.2, May 12, 2005) and Exposure Analysis Modeling System (EXAMS v2.98.04.06, April 25, 2005), simulation models, were coupled with the input PE5.pl.shell.  The Provisional Cranberry Model was used to assess cranberry.  The model does incorporate a degradation component
[b] From the PRZM-GW model.  
   
V.  DEEM-FCID Program and Consumption Information

Chlorantraniliprole chronic dietary exposure assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database DEEM-FCID, Version 3.16, which incorporates consumption data from 2003 to 2008 from USDA's NHANES/WWEIA.  The data are based on the reported consumption of more than 20,000 individuals over two non-consecutive survey days.  Foods "as consumed" (e.g., apple pie) are linked to EPA-defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA.  For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups.  However, for acute exposure assessment, consumption data are retained as individual consumption events.  Based on analysis of the 2003-2008 WWEIA consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50-99 years old.

For a chronic dietary exposure assessment, an estimate of the residue level in each food or food-form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food form to produce a residue intake estimate.  The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure.  Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD.  This procedure is performed for each population subgroup.

VI.  Toxicological Information

The toxicity database for chlorantraniliprole is complete. No acute hazard, attributable to a single dose, was identified; therefore, an acute dietary endpoint was not selected for quantitative risk assessment.  A composite uncertainty factor of 100 to account for interspecies extrapolation and intraspecies variability is applied to the NOAEL to derive a cPAD of 1.58 mg/kg/day.

The chlorantraniliprole risk assessment team evaluated the quality of the toxicity and exposure data and, based on these data, recommended that the Food Quality Protection Act (FQPA) Safety Factor be reduced to 1X.  

Based on the weight of evidence of the available scientific data, and in accordance with EPA's Final Guidelines for Carcinogen Risk Assessment (March 2005), chlorantraniliprole may be classified as "Not Likely to Be Carcinogenic to Humans."

The toxicity endpoints pertinent for human risk assessment are summarized in Table 3.

Table 3.    Summary of Toxicological Doses and Endpoints for Chlorantraniliprole for Use in Dietary Human Health Risk Assessments.
Exposure/
Scenario
                              Point of Departure
                        Uncertainty/FQPA Safety Factors
                RfD, PAD, Level of Concern for Risk Assessment
                        Study and Toxicological Effects
                        Acute Dietary (All Populations)
                                      NA
                                      NA
                                      NA
No acute hazard, attributable to a single dose, was identified; therefore, an acute dietary endpoint was not selected for quantitative risk assessment.
                       Chronic Dietary (All Populations)
                             NOAEL= 158 mg/kg/day
                                   UFA= 10x
                                    UFH=10x
                                  FQPA SF= 1x
                         Chronic RfD = 1.58 mg/kg/day
                                       
                             cPAD = 1.58 mg/kg/day
                         18-Month Oral (feeding)/mouse
                                       
LOAEL = 935 mg/kg/day based on eosinophilic foci accompanied by hepatocellular hypertrophy and increased liver weight (males only).
                       Cancer (oral, dermal, inhalation)
Classification:  "Not likely to be Carcinogenic to Humans" based on weight of evidence of data: no treatment-related tumors were reported in the submitted chronic and oncogenicity studies in rats and mice or in the subchronic studies in mice, dogs and rats; and no mutagenic concern was reported in the genotoxicity studies.
Abbreviations:  UF = uncertainty factor, UFA = extrapolation from animal to human (interspecies), UFH = potential variation in sensitivity among members of the human population (intraspecies), UFFQPA = FQPA Safety Factor, NOAEL = no-observed adverse-effect level, LOAEL = lowest-observed adverse-effect level, RfD = reference dose (a = acute, c = chronic), PAD = population-adjusted dose, LOC = level of concern.

VII.  Results/Discussion 

As stated above, for chronic assessments, HED is concerned when dietary risk exceeds 100% of the PAD.  The DEEM-FCID analyses estimate the dietary exposure of the U.S. population and various population subgroups.  The results reported in Table 4 are for the general U.S. Population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, females 13-49, adults 20-49, and adults 50+ years.  

Results of Chronic Dietary (Food and Drinking Water) Exposure Analysis: The results of the chronic dietary exposure analysis are reported in the summary table below.  

 Table 4.  Summary of Dietary (Food and Drinking Water) Exposure and Risk for Chlorantraniliprole.
                              Population Subgroup
                                Chronic Dietary
                                        
                                Dietary Exposure
                                  (mg/kg/day)
                                    % cPAD*
 General U.S. Population
                                    0.036207
                                      2.3
 All Infants (<1 year old)
                                    0.060811
                                      3.8
 Children 1-2 years old*
                                    0.105269
                                      6.7
 Children 3-5 years old
                                    0.081499
                                      5.2
 Children 6-12 years old
                                    0.046110
                                      2.9
 Youth 13-19 years old
                                    0.027234
                                      1.7
 Adults 20-49 years old
                                    0.030559
                                      1.9
 Adults 50-99 years old
                                    0.030166
                                      1.9
 Females 13-49 years old
                                    0.029398
                                      1.9
*The subpopulation(s) with the highest risk estimate. 
 
 VIII.  Characterization of Inputs/Outputs
 
The chlorantraniliprole dietary exposure risk estimates are unrefined and considered conservative since they: (1) assume that 100% of the registered/proposed crops were treated with chlorantraniliprole; (2) use established or recommended tolerance level residues for all crops; (3) use default/conservative processing factors for processed commodities; and (4) use conservative, modeled drinking water estimates.  The tolerances are derived from crop field trials or conservative data translations and default processing factors.   At this time, the dietary risks (food and water) of chlorantraniliprole are < 6.7% and are not of concern to HED; therefore no further refinement is required.  

 IX.  Conclusions
 
 A conservative dietary (food and drinking water) exposure and risk assessment was performed for chlorantraniliprole.  The assumptions incorporated into the assessment included 100% CT, default processing factors, established/proposed tolerance level residues, and conservative EDWCs.  The chronic dietary (food and drinking water) exposure estimates are below HED's level of concern (<100% cPAD) for the general U.S. population and all population subgroups.  Chlorantraniliprole dietary (food and drinking water) risk is 2.3% of the cPAD for the general U.S. population and 6.7% for children 1-2 years old, the most highly exposed population subgroup.  HED is confident that the assessment does not underestimate risk to the general U.S. population or any population subgroup.
 
 X.  List of Attachments
   * Chronic Residue Input file
   * Chronic Results File
   * Structures of Chlorantraniliprole and Possible Metabolites 


 Attachment 1: Chronic Food Plus Water Input File 

Filename: C:\Documents and Settings\krury\My Documents\My Work Files\Chlorantraniliprole\Peanut and Green Onion\DEEM Files\CHLORANTRANILIPROLECHRONIC green onion peanut 110813.R08
Chemical: chlorantraniliprole
RfD(Chronic): 1.58 mg/kg bw/day  NOEL(Chronic): 158 mg/kg bw/day
RfD(Acute): 0 mg/kg bw/day  NOEL(Acute):  0 mg/kg bw/day
Date created/last modified: 11-08-2013/13:25:05       Program ver. 3.16, 03-08-d
Comment: Only a chronic endpoint; there is no acute endpoint
-----------------------------------------------------------------------------------
   EPA     Crop                                   Def Res     Adj.Factors   Comment
   Code     Grp  Commodity Name                    (ppm)       #1    #2   
---------- ---- -------------------------------  ----------  ------ ------  -------
0101050000 1AB  Beet, garden, roots                0.300000   1.000  1.000  
0101050001 1AB  Beet, garden, roots-babyfood       0.300000   1.000  1.000  
0101052000 1A   Beet, sugar                        0.300000   1.000  1.000  
0101052001 1A   Beet, sugar-babyfood               0.300000   1.000  1.000  
0101053000 1A   Beet, sugar, molasses              9.000000   1.000  1.000  
0101053001 1A   Beet, sugar, molasses-babyfood     9.000000   1.000  1.000  
0101067000 1AB  Burdock                            0.300000   1.000  1.000  
0101078000 1AB  Carrot                             0.300000   1.000  1.000  
0101078001 1AB  Carrot-babyfood                    0.300000   1.000  1.000  
0101079000 1AB  Carrot, juice                      0.300000   1.000  1.000  
0101084000 1AB  Celeriac                           0.300000   1.000  1.000  
0101100000 1AB  Chicory, roots                     0.300000   1.000  1.000  
0101168000 1AB  Ginseng, dried                     0.300000   1.000  1.000  
0101190000 1AB  Horseradish                        0.300000   1.000  1.000  
0101250000 1AB  Parsley, turnip rooted             0.300000   1.000  1.000  
0101251000 1AB  Parsnip                            0.300000   1.000  1.000  
0101251001 1AB  Parsnip-babyfood                   0.300000   1.000  1.000  
0101314000 1AB  Radish, roots                      0.300000   1.000  1.000  
0101316000 1AB  Radish, Oriental, roots            0.300000   1.000  1.000  
0101327000 1AB  Rutabaga                           0.300000   1.000  1.000  
0101331000 1AB  Salsify, roots                     0.300000   1.000  1.000  
0101388000 1AB  Turnip, roots                      0.300000   1.000  1.000  
0103015000 1CD  Arrowroot, flour                   0.300000   1.000  1.000  
0103015001 1CD  Arrowroot, flour-babyfood          0.300000   1.000  1.000  
0103017000 1CD  Artichoke, Jerusalem               0.300000   1.000  1.000  
0103082000 1CD  Cassava                            0.300000   1.000  1.000  
0103082001 1CD  Cassava-babyfood                   0.300000   1.000  1.000  
0103139000 1CD  Dasheen, corm                      0.300000   1.000  1.000  
0103166000 1CD  Ginger                             0.300000   1.000  1.000  
0103166001 1CD  Ginger-babyfood                    0.300000   1.000  1.000  
0103167000 1CD  Ginger, dried                      0.300000   1.000  1.000  
0103296000 1C   Potato, chips                      0.300000   1.000  1.000  
0103297000 1C   Potato, dry (granules/ flakes)     0.300000   6.500  1.000  
0103297001 1C   Potato, dry (granules/ flakes)-b   0.300000   6.500  1.000  
0103298000 1C   Potato, flour                      0.300000   6.500  1.000  
0103298001 1C   Potato, flour-babyfood             0.300000   6.500  1.000  
0103299000 1C   Potato, tuber, w/peel              0.300000   1.000  1.000  
0103299001 1C   Potato, tuber, w/peel-babyfood     0.300000   1.000  1.000  
0103300000 1C   Potato, tuber, w/o peel            0.300000   1.000  1.000  
0103300001 1C   Potato, tuber, w/o peel-babyfood   0.300000   1.000  1.000  
0103366000 1CD  Sweet potato                       0.300000   1.000  1.000  
0103366001 1CD  Sweet potato-babyfood              0.300000   1.000  1.000  
0103371000 1CD  Tanier, corm                       0.300000   1.000  1.000  
0103387000 1CD  Turmeric                           0.300000   1.000  1.000  
0103406000 1CD  Yam, true                          0.300000   1.000  1.000  
0103407000 1CD  Yam bean                           0.300000   1.000  1.000  
0200051000 2    Beet, garden, tops                40.000000   1.000  1.000  
0200101000 2    Chicory, tops                     40.000000   1.000  1.000  
0200140000 2    Dasheen, leaves                   40.000000   1.000  1.000  
0200315000 2    Radish, tops                      40.000000   1.000  1.000  
0200317000 2    Radish, Oriental, tops            40.000000   1.000  1.000  
0200332000 2    Salsify, tops                     40.000000   1.000  1.000  
0301165000 3A   Garlic, bulb                       0.300000   1.000  1.000  
0301165001 3A   Garlic, bulb-babyfood              0.300000   1.000  1.000  
0301237000 3A   Onion, bulb                        0.300000   1.000  1.000  
0301237001 3A   Onion, bulb-babyfood               0.300000   1.000  1.000  
0301238000 3A   Onion, bulb, dried                 0.300000   9.000  1.000  
0301238001 3A   Onion, bulb, dried-babyfood        0.300000   9.000  1.000  
0301338000 3A   Shallot, bulb                      0.300000   1.000  1.000  
0302103000 3B   Chive, fresh leaves               25.000000   1.000  1.000  
0302198000 3B   Leek                               3.000000   1.000  1.000  
0302239000 3B   Onion, green                       3.000000   1.000  1.000  
0302338500 3B   Shallot, fresh leaves              3.000000   1.000  1.000  
0401005000 4A   Amaranth, leafy                   13.000000   1.000  1.000  
0401018000 4A   Arugula                           13.000000   1.000  1.000  
0401104000 4A   Chrysanthemum, garland            13.000000   1.000  1.000  
0401133000 4A   Cress, garden                     13.000000   1.000  1.000  
0401134000 4A   Cress, upland                     13.000000   1.000  1.000  
0401138000 4A   Dandelion, leaves                 13.000000   1.000  1.000  
0401150000 4A   Endive                            13.000000   1.000  1.000  
0401204000 4A   Lettuce, head                     13.000000   1.000  1.000  
0401205000 4A   Lettuce, leaf                     13.000000   1.000  1.000  
0401248000 4A   Parsley, leaves                   13.000000   1.000  1.000  
0401313000 4A   Radicchio                         13.000000   1.000  1.000  
0401355000 4A   Spinach                           13.000000   1.000  1.000  
0401355001 4A   Spinach-babyfood                  13.000000   1.000  1.000  
0402076000 4B   Cardoon                           13.000000   1.000  1.000  
0402085000 4B   Celery                            13.000000   1.000  1.000  
0402085001 4B   Celery-babyfood                   13.000000   1.000  1.000  
0402086000 4B   Celery, juice                     13.000000   1.000  1.000  
0402087000 4B   Celtuce                           13.000000   1.000  1.000  
0402152000 4B   Fennel, Florence                  13.000000   1.000  1.000  
0402322000 4B   Rhubarb                           13.000000   1.000  1.000  
0402367000 4B   Swiss chard                       13.000000   1.000  1.000  
0501061000 5A   Broccoli                           4.000000   1.000  1.000  
0501061001 5A   Broccoli-babyfood                  4.000000   1.000  1.000  
0501062000 5A   Broccoli, Chinese                  4.000000   1.000  1.000  
0501064000 5A   Brussels sprouts                   4.000000   1.000  1.000  
0501069000 5A   Cabbage                            4.000000   1.000  1.000  
0501071000 5A   Cabbage, Chinese, napa             4.000000   1.000  1.000  
0501072000 5A   Cabbage, Chinese, mustard          4.000000   1.000  1.000  
0501083000 5A   Cauliflower                        4.000000   1.000  1.000  
0501196000 5A   Kohlrabi                           4.000000   1.000  1.000  
0502063000 5B   Broccoli raab                     11.000000   1.000  1.000  
0502070000 5B   Cabbage, Chinese, bok choy        11.000000   1.000  1.000  
0502117000 5B   Collards                          11.000000   1.000  1.000  
0502194000 5B   Kale                              11.000000   1.000  1.000  
0502229000 5B   Mustard greens                    11.000000   1.000  1.000  
0502318000 5B   Rape greens                       11.000000   1.000  1.000  
0502389000 5B   Turnip, greens                    11.000000   1.000  1.000  
0600347000 6    Soybean, seed                      2.000000   1.000  1.000  
0600349000 6    Soybean, soy milk                  2.000000   1.000  1.000  
0600349001 6    Soybean, soy milk-babyfood or in   2.000000   1.000  1.000  
0600350000 6    Soybean, oil                       2.000000   1.000  1.000  
0600350001 6    Soybean, oil-babyfood              2.000000   1.000  1.000  
0601043000 6A   Bean, snap, succulent              2.000000   1.000  1.000  
0601043001 6A   Bean, snap, succulent-babyfood     2.000000   1.000  1.000  
0601257000 6A   Pea, edible podded, succulent      2.000000   1.000  1.000  
0601349500 6AB  Soybean, vegetable                 2.000000   1.000  1.000  
0602031000 6B   Bean, broad, succulent             2.000000   1.000  1.000  
0602033000 6B   Bean, cowpea, succulent            2.000000   1.000  1.000  
0602037000 6B   Bean, lima, succulent              2.000000   1.000  1.000  
0602255000 6B   Pea, succulent                     2.000000   1.000  1.000  
0602255001 6B   Pea, succulent-babyfood            2.000000   1.000  1.000  
0602259000 6B   Pea, pigeon, succulent             2.000000   1.000  1.000  
0603030000 6C   Bean, black, seed                  2.000000   1.000  1.000  
0603032000 6C   Bean, broad, seed                  2.000000   1.000  1.000  
0603034000 6C   Bean, cowpea, seed                 2.000000   1.000  1.000  
0603035000 6C   Bean,  great northern, seed        2.000000   1.000  1.000  
0603036000 6C   Bean, kidney, seed                 2.000000   1.000  1.000  
0603038000 6C   Bean, lima, seed                   2.000000   1.000  1.000  
0603039000 6C   Bean, mung, seed                   2.000000   1.000  1.000  
0603040000 6C   Bean, navy, seed                   2.000000   1.000  1.000  
0603041000 6C   Bean, pink, seed                   2.000000   1.000  1.000  
0603042000 6C   Bean, pinto, seed                  2.000000   1.000  1.000  
0603098000 6C   Chickpea, seed                     2.000000   1.000  1.000  
0603098001 6C   Chickpea, seed-babyfood            2.000000   1.000  1.000  
0603099000 6C   Chickpea, flour                    2.000000   1.000  1.000  
0603182000 6C   Guar, seed                         2.000000   1.000  1.000  
0603182001 6C   Guar, seed-babyfood                2.000000   1.000  1.000  
0603203000 6C   Lentil, seed                       2.000000   1.000  1.000  
0603256000 6C   Pea, dry                           2.000000   1.000  1.000  
0603256001 6C   Pea, dry-babyfood                  2.000000   1.000  1.000  
0603258000 6C   Pea, pigeon, seed                  2.000000   1.000  1.000  
0603348000 6C   Soybean, flour                     2.000000   1.000  1.000  
0603348001 6C   Soybean, flour-babyfood            2.000000   1.000  1.000  
0801374000 8A   Tomatillo                          1.400000   1.000  1.000  
0801375000 8A   Tomato                             1.400000   1.000  1.000  
0801375001 8A   Tomato-babyfood                    1.400000   1.000  1.000  
0801376000 8A   Tomato, paste                      1.400000   5.400  1.000  
0801376001 8A   Tomato, paste-babyfood             1.400000   5.400  1.000  
0801377000 8A   Tomato, puree                      1.400000   3.300  1.000  
0801377001 8A   Tomato, puree-babyfood             1.400000   3.300  1.000  
0801378000 8A   Tomato, dried                      1.400000  14.300  1.000  
0801378001 8A   Tomato, dried-babyfood             1.400000  14.300  1.000  
0801379000 8A   Tomato, juice                      1.400000   1.500  1.000  
0801380000 8A   Tomato, Tree                       1.400000   1.000  1.000  
0802148000 8BC  Eggplant                           1.400000   1.000  1.000  
0802234000 8BC  Okra                               1.400000   1.000  1.000  
0802270000 8B   Pepper, bell                       1.400000   1.000  1.000  
0802270001 8B   Pepper, bell-babyfood              1.400000   1.000  1.000  
0802271000 8B   Pepper, bell, dried                1.400000   1.000  1.000  
0802271001 8B   Pepper, bell, dried-babyfood       1.400000   1.000  1.000  
0802272000 8BC  Pepper, nonbell                    1.400000   1.000  1.000  
0802272001 8BC  Pepper, nonbell-babyfood           1.400000   1.000  1.000  
0802273000 8BC  Pepper, nonbell, dried             1.400000   1.000  1.000  
0901075000 9A   Cantaloupe                         0.500000   1.000  1.000  
0901187000 9A   Honeydew melon                     0.500000   1.000  1.000  
0901399000 9A   Watermelon                         0.500000   1.000  1.000  
0901400000 9A   Watermelon, juice                  0.500000   1.000  1.000  
0902021000 9B   Balsam pear                        0.500000   1.000  1.000  
0902088000 9B   Chayote, fruit                     0.500000   1.000  1.000  
0902102000 9B   Chinese waxgourd                   0.500000   1.000  1.000  
0902135000 9B   Cucumber                           0.500000   1.000  1.000  
0902308000 9B   Pumpkin                            0.500000   1.000  1.000  
0902309000 9B   Pumpkin, seed                      0.500000   1.000  1.000  
0902356000 9B   Squash, summer                     0.500000   1.000  1.000  
0902356001 9B   Squash, summer-babyfood            0.500000   1.000  1.000  
0902357000 9B   Squash, winter                     0.500000   1.000  1.000  
0902357001 9B   Squash, winter-babyfood            0.500000   1.000  1.000  
1001106000 10A  Citron                             1.400000   1.000  1.000  
1001107000 10A  Citrus hybrids                     1.400000   1.000  1.000  
1001108000 10A  Citrus, oil                        1.400000   1.000  1.000  
1001240000 10A  Orange                             1.400000   1.000  1.000  
1001241000 10A  Orange, juice                      1.400000   1.800  1.000  
1001241001 10A  Orange, juice-babyfood             1.400000   1.800  1.000  
1001242000 10A  Orange, peel                       1.400000   1.000  1.000  
1001369000 10A  Tangerine                          1.400000   1.000  1.000  
1001370000 10A  Tangerine, juice                   1.400000   2.300  1.000  
1002197000 10B  Kumquat                            1.400000   1.000  1.000  
1002199000 10B  Lemon                              1.400000   1.000  1.000  
1002200000 10B  Lemon, juice                       1.400000   2.000  1.000  
1002200001 10B  Lemon, juice-babyfood              1.400000   2.000  1.000  
1002201000 10B  Lemon, peel                        1.400000   1.000  1.000  
1002206000 10B  Lime                               1.400000   1.000  1.000  
1002207000 10B  Lime, juice                        1.400000   2.000  1.000  
1002207001 10B  Lime, juice-babyfood               1.400000   2.000  1.000  
1003180000 10C  Grapefruit                         1.400000   1.000  1.000  
1003181000 10C  Grapefruit, juice                  1.400000   2.100  1.000  
1003307000 10C  Pummelo                            1.400000   1.000  1.000  
1100007000 11   Apple, fruit with peel             1.200000   1.000  1.000  
1100008000 11   Apple, peeled fruit                1.200000   1.000  1.000  
1100008001 11   Apple, peeled fruit-babyfood       1.200000   1.000  1.000  
1100009000 11   Apple, dried                       1.200000   8.000  1.000  
1100009001 11   Apple, dried-babyfood              1.200000   8.000  1.000  
1100010000 11   Apple, juice                       1.200000   1.300  1.000  
1100010001 11   Apple, juice-babyfood              1.200000   1.300  1.000  
1100011000 11   Apple, sauce                       1.200000   1.000  1.000  
1100011001 11   Apple, sauce-babyfood              1.200000   1.000  1.000  
1100129000 11   Crabapple                          1.200000   1.000  1.000  
1100173500 11   Goji berry                         1.400000   1.000  1.000  
1100210000 11   Loquat                             1.200000   1.000  1.000  
1100266000 11   Pear                               1.200000   1.000  1.000  
1100266001 11   Pear-babyfood                      1.200000   1.000  1.000  
1100267000 11   Pear, dried                        1.200000   6.250  1.000  
1100268000 11   Pear, juice                        1.200000   1.000  1.000  
1100268001 11   Pear, juice-babyfood               1.200000   1.000  1.000  
1100310000 11   Quince                             1.200000   1.000  1.000  
1201090000 12A  Cherry                             2.000000   1.000  1.000  
1201090001 12A  Cherry-babyfood                    2.000000   1.000  1.000  
1201091000 12A  Cherry, juice                      2.000000   1.500  1.000  
1201091001 12A  Cherry, juice-babyfood             2.000000   1.500  1.000  
1202012000 12B  Apricot                            4.000000   1.000  1.000  
1202012001 12B  Apricot-babyfood                   4.000000   1.000  1.000  
1202013000 12B  Apricot, dried                     4.000000   6.000  1.000  
1202014000 12B  Apricot, juice                     4.000000   1.000  1.000  
1202014001 12B  Apricot, juice-babyfood            4.000000   1.000  1.000  
1202230000 12B  Nectarine                          4.000000   1.000  1.000  
1202260000 12B  Peach                              4.000000   1.000  1.000  
1202260001 12B  Peach-babyfood                     4.000000   1.000  1.000  
1202261000 12B  Peach, dried                       4.000000   7.000  1.000  
1202261001 12B  Peach, dried-babyfood              4.000000   7.000  1.000  
1202262000 12B  Peach, juice                       4.000000   1.000  1.000  
1202262001 12B  Peach, juice-babyfood              4.000000   1.000  1.000  
1203285000 12C  Plum                               4.000000   1.000  1.000  
1203285001 12C  Plum-babyfood                      4.000000   1.000  1.000  
1203286000 12C  Plum, prune, fresh                 4.000000   1.000  1.000  
1203286001 12C  Plum, prune, fresh-babyfood        4.000000   1.000  1.000  
1203287000 12C  Plum, prune, dried                 4.000000   5.000  1.000  
1203287001 12C  Plum, prune, dried-babyfood        4.000000   5.000  1.000  
1203288000 12C  Plum, prune, juice                 4.000000   1.400  1.000  
1203288001 12C  Plum, prune, juice-babyfood        4.000000   1.400  1.000  
1301055000 13A  Blackberry                         1.800000   1.000  1.000  
1301056000 13A  Blackberry, juice                  1.800000   1.000  1.000  
1301056001 13A  Blackberry, juice-babyfood         1.800000   1.000  1.000  
1301058000 13A  Boysenberry                        1.800000   1.000  1.000  
1301208000 13A  Loganberry                         1.800000   1.000  1.000  
1301320000 13A  Raspberry                          1.800000   1.000  1.000  
1301320001 13A  Raspberry-babyfood                 1.800000   1.000  1.000  
1301321000 13A  Raspberry, juice                   1.800000   1.000  1.000  
1301321001 13A  Raspberry, juice-babyfood          1.800000   1.000  1.000  
1302057000 13B  Blueberry                          2.500000   1.000  1.000  
1302057001 13B  Blueberry-babyfood                 2.500000   1.000  1.000  
1302136000 13B  Currant                            2.500000   1.000  1.000  
1302137000 13B  Currant, dried                     2.500000   1.000  1.000  
1302149000 13B  Elderberry                         2.500000   1.000  1.000  
1302174000 13B  Gooseberry                         2.500000   1.000  1.000  
1302191000 13B  Huckleberry                        2.500000   1.000  1.000  
1303227000 13C  Mulberry                           2.500000   1.000  1.000  
1304175000 13D  Grape                              2.500000   1.000  1.000  
1304176000 13D  Grape, juice                       2.500000   1.200  1.000  
1304176001 13D  Grape, juice-babyfood              2.500000   1.200  1.000  
1304179000 13D  Grape, wine and sherry             2.500000   1.000  1.000  
1307130000 13G  Cranberry                          1.000000   1.000  1.000  
1307130001 13G  Cranberry-babyfood                 1.000000   1.000  1.000  
1307131000 13G  Cranberry, dried                   1.000000   1.000  1.000  
1307132000 13G  Cranberry, juice                   1.000000   1.100  1.000  
1307132001 13G  Cranberry, juice-babyfood          1.000000   1.100  1.000  
1307359000 13G  Strawberry                         1.000000   1.000  1.000  
1307359001 13G  Strawberry-babyfood                1.000000   1.000  1.000  
1307360000 13G  Strawberry, juice                  1.000000   1.000  1.000  
1307360001 13G  Strawberry, juice-babyfood         1.000000   1.000  1.000  
1400003000 14   Almond                             0.020000   1.000  1.000  
1400003001 14   Almond-babyfood                    0.020000   1.000  1.000  
1400004000 14   Almond, oil                        0.020000   1.000  1.000  
1400004001 14   Almond, oil-babyfood               0.020000   1.000  1.000  
1400059000 14   Brazil nut                         0.020000   1.000  1.000  
1400068000 14   Butternut                          0.020000   1.000  1.000  
1400081000 14   Cashew                             0.020000   1.000  1.000  
1400092000 14   Chestnut                           0.020000   1.000  1.000  
1400155000 14   Hazelnut                           0.020000   1.000  1.000  
1400156000 14   Hazelnut, oil                      0.020000   1.000  1.000  
1400185000 14   Hickory nut                        0.020000   1.000  1.000  
1400213000 14   Macadamia nut                      0.020000   1.000  1.000  
1400269000 14   Pecan                              0.020000   1.000  1.000  
1400278000 14   Pine nut                           0.020000   1.000  1.000  
1400282000 14   Pistachio                          0.020000   1.000  1.000  
1400391000 14   Walnut                             0.020000   1.000  1.000  
1500025000 15   Barley, pearled barley             6.000000   1.000  1.000  
1500025001 15   Barley, pearled barley-babyfood    6.000000   1.000  1.000  
1500026000 15   Barley, flour                      6.000000   1.000  1.000  
1500026001 15   Barley, flour-babyfood             6.000000   1.000  1.000  
1500027000 15   Barley, bran                       6.000000   1.000  1.000  
1500065000 15   Buckwheat                          6.000000   1.000  1.000  
1500066000 15   Buckwheat, flour                   6.000000   1.000  1.000  
1500120000 15   Corn, field, flour                 0.040000   1.000  1.000  
1500120001 15   Corn, field, flour-babyfood        0.040000   1.000  1.000  
1500121000 15   Corn, field, meal                  0.040000   1.000  1.000  
1500121001 15   Corn, field, meal-babyfood         0.040000   1.000  1.000  
1500122000 15   Corn, field, bran                  0.040000   1.000  1.000  
1500123000 15   Corn, field, starch                0.040000   1.000  1.000  
1500123001 15   Corn, field, starch-babyfood       0.040000   1.000  1.000  
1500124000 15   Corn, field, syrup                 0.040000   1.500  1.000  
1500124001 15   Corn, field, syrup-babyfood        0.040000   1.500  1.000  
1500125000 15   Corn, field, oil                   0.040000   1.000  1.000  
1500125001 15   Corn, field, oil-babyfood          0.040000   1.000  1.000  
1500126000 15   Corn, pop                          0.040000   1.000  1.000  
1500127000 15   Corn, sweet                        0.040000   1.000  1.000  
1500127001 15   Corn, sweet-babyfood               0.040000   1.000  1.000  
1500226000 15   Millet, grain                      6.000000   1.000  1.000  
1500231000 15   Oat, bran                          6.000000   1.000  1.000  
1500232000 15   Oat, flour                         6.000000   1.000  1.000  
1500232001 15   Oat, flour-babyfood                6.000000   1.000  1.000  
1500233000 15   Oat, groats/rolled oats            6.000000   1.000  1.000  
1500233001 15   Oat, groats/rolled oats-babyfood   6.000000   1.000  1.000  
1500323000 15   Rice, white                        0.150000   1.000  1.000  
1500323001 15   Rice, white-babyfood               0.150000   1.000  1.000  
1500324000 15   Rice, brown                        0.150000   1.000  1.000  
1500324001 15   Rice, brown-babyfood               0.150000   1.000  1.000  
1500325000 15   Rice, flour                        0.150000   1.000  1.000  
1500325001 15   Rice, flour-babyfood               0.150000   1.000  1.000  
1500326000 15   Rice, bran                         0.150000   1.000  1.000  
1500326001 15   Rice, bran-babyfood                0.150000   1.000  1.000  
1500328000 15   Rye, grain                         6.000000   1.000  1.000  
1500329000 15   Rye, flour                         6.000000   1.000  1.000  
1500344000 15   Sorghum, grain                     6.000000   1.000  1.000  
1500345000 15   Sorghum, syrup                     6.000000   1.000  1.000  
1500381000 15   Triticale, flour                   6.000000   1.000  1.000  
1500381001 15   Triticale, flour-babyfood          6.000000   1.000  1.000  
1500401000 15   Wheat, grain                       6.000000   1.000  1.000  
1500401001 15   Wheat, grain-babyfood              6.000000   1.000  1.000  
1500402000 15   Wheat, flour                       0.160000   1.000  1.000  
1500402001 15   Wheat, flour-babyfood              0.160000   1.000  1.000  
1500403000 15   Wheat, germ                        0.490000   1.000  1.000  
1500404000 15   Wheat, bran                        0.450000   1.000  1.000  
1500405000 15   Wild rice                          0.150000   1.000  1.000  
1800002000 18   Alfalfa, seed                      7.000000   1.000  1.000  
1901028000 19A  Basil, fresh leaves               25.000000   1.000  1.000  
1901028001 19A  Basil, fresh leaves-babyfood      25.000000   1.000  1.000  
1901029000 19A  Basil, dried leaves               90.000000   1.000  1.000  
1901029001 19A  Basil, dried leaves-babyfood      90.000000   1.000  1.000  
1901102500 19A  Chive, dried leaves               90.000000   1.000  1.000  
1901118000 19A  Cilantro, leaves                  25.000000   1.000  1.000  
1901118001 19A  Cilantro, leaves-babyfood         25.000000   1.000  1.000  
1901144000 19A  Dillweed                          25.000000   1.000  1.000  
1901184000 19A  Herbs, other                      25.000000   1.000  1.000  
1901184001 19A  Herbs, other-babyfood             25.000000   1.000  1.000  
1901202000 19A  Lemongrass                        25.000000   1.000  1.000  
1901220000 19A  Marjoram                          25.000000   1.000  1.000  
1901220001 19A  Marjoram-babyfood                 25.000000   1.000  1.000  
1901249000 19A  Parsley, dried leaves             90.000000   1.000  1.000  
1901249001 19A  Parsley, dried leaves-babyfood    90.000000   1.000  1.000  
1901334000 19A  Savory                            25.000000   1.000  1.000  
1902105000 19B  Cinnamon                          90.000000   1.000  1.000  
1902105001 19B  Cinnamon-babyfood                 90.000000   1.000  1.000  
1902119000 19B  Coriander, seed                   90.000000   1.000  1.000  
1902119001 19B  Coriander, seed-babyfood          90.000000   1.000  1.000  
1902143000 19B  Dill, seed                        90.000000   1.000  1.000  
1902274000 19B  Pepper, black and white           90.000000   1.000  1.000  
1902274001 19B  Pepper, black and white-babyfood  90.000000   1.000  1.000  
1902354000 19B  Spices, other                     90.000000   1.000  1.000  
1902354001 19B  Spices, other-babyfood            90.000000   1.000  1.000  
2001163000 20A  Flax seed, oil                     2.000000   1.000  1.000  
2001319000 20A  Rapeseed, oil                      2.000000   1.000  1.000  
2001319001 20A  Rapeseed, oil-babyfood             2.000000   1.000  1.000  
2001336000 20A  Sesame, seed                       0.300000   1.000  1.000  
2001336001 20A  Sesame, seed-babyfood              0.300000   1.000  1.000  
2001337000 20A  Sesame, oil                        0.300000   1.000  1.000  
2001337001 20A  Sesame, oil-babyfood               0.300000   1.000  1.000  
2002330000 20B  Safflower, oil                     2.000000   1.000  1.000  
2002330001 20B  Safflower, oil-babyfood            2.000000   1.000  1.000  
2002364000 20B  Sunflower, seed                    2.000000   1.000  1.000  
2002365000 20B  Sunflower, oil                     2.000000   1.000  1.000  
2002365001 20B  Sunflower, oil-babyfood            2.000000   1.000  1.000  
2003128000 20C  Cottonseed, oil                    0.300000   1.000  1.000  
2003128001 20C  Cottonseed, oil-babyfood           0.300000   1.000  1.000  
3100044000 31   Beef, meat                         0.100000   1.000  1.000  
3100044001 31   Beef, meat-babyfood                0.100000   1.000  1.000  
3100045000 31   Beef, meat, dried                  0.100000   1.920  1.000  
3100046000 31   Beef, meat byproducts              0.500000   1.000  1.000  
3100046001 31   Beef, meat byproducts-babyfood     0.500000   1.000  1.000  
3100047000 31   Beef, fat                          0.500000   1.000  1.000  
3100047001 31   Beef, fat-babyfood                 0.500000   1.000  1.000  
3100048000 31   Beef, kidney                       0.500000   1.000  1.000  
3100049000 31   Beef, liver                        0.500000   1.000  1.000  
3100049001 31   Beef, liver-babyfood               0.500000   1.000  1.000  
3200169000 32   Goat, meat                         0.100000   1.000  1.000  
3200170000 32   Goat, meat byproducts              0.500000   1.000  1.000  
3200171000 32   Goat, fat                          0.500000   1.000  1.000  
3200172000 32   Goat, kidney                       0.500000   1.000  1.000  
3200173000 32   Goat, liver                        0.500000   1.000  1.000  
3300189000 33   Horse, meat                        0.100000   1.000  1.000  
3400290000 34   Pork, meat                         0.020000   1.000  1.000  
3400290001 34   Pork, meat-babyfood                0.020000   1.000  1.000  
3400291000 34   Pork, skin                         0.050000   1.000  1.000  
3400292000 34   Pork, meat byproducts              0.050000   1.000  1.000  
3400292001 34   Pork, meat byproducts-babyfood     0.050000   1.000  1.000  
3400293000 34   Pork, fat                          0.050000   1.000  1.000  
3400293001 34   Pork, fat-babyfood                 0.050000   1.000  1.000  
3400294000 34   Pork, kidney                       0.050000   1.000  1.000  
3400295000 34   Pork, liver                        0.050000   1.000  1.000  
3500339000 35   Sheep, meat                        0.100000   1.000  1.000  
3500339001 35   Sheep, meat-babyfood               0.100000   1.000  1.000  
3500340000 35   Sheep, meat byproducts             0.500000   1.000  1.000  
3500341000 35   Sheep, fat                         0.500000   1.000  1.000  
3500341001 35   Sheep, fat-babyfood                0.500000   1.000  1.000  
3500342000 35   Sheep, kidney                      0.500000   1.000  1.000  
3500343000 35   Sheep, liver                       0.500000   1.000  1.000  
3600222000 36   Milk, fat                          0.100000   1.000  1.000  
3600222001 36   Milk, fat-baby food/infant formu   0.100000   1.000  1.000  
3600223000 36   Milk, nonfat solids                0.100000   1.000  1.000  
3600223001 36   Milk, nonfat solids-baby food/in   0.100000   1.000  1.000  
3600224000 36   Milk, water                        0.100000   1.000  1.000  
3600224001 36   Milk, water-babyfood/infant form   0.100000   1.000  1.000  
3600225001 36   Milk, sugar (lactose)-baby food/   0.100000   1.000  1.000  
3800221000 38   Meat, game                         0.100000   1.000  1.000  
3900312000 39   Rabbit, meat                       0.100000   1.000  1.000  
4000093000 40   Chicken, meat                      0.100000   1.000  1.000  
4000093001 40   Chicken, meat-babyfood             0.100000   1.000  1.000  
4000094000 40   Chicken, liver                     0.310000   1.000  1.000  
4000095000 40   Chicken, meat byproducts           0.310000   1.000  1.000  
4000095001 40   Chicken, meat byproducts-babyfoo   0.310000   1.000  1.000  
4000096000 40   Chicken, fat                       0.310000   1.000  1.000  
4000096001 40   Chicken, fat-babyfood              0.310000   1.000  1.000  
4000097000 40   Chicken, skin                      0.310000   1.000  1.000  
4000097001 40   Chicken, skin-babyfood             0.310000   1.000  1.000  
5000382000 50   Turkey, meat                       0.100000   1.000  1.000  
5000382001 50   Turkey, meat-babyfood              0.100000   1.000  1.000  
5000383000 50   Turkey, liver                      0.310000   1.000  1.000  
5000383001 50   Turkey, liver-babyfood             0.310000   1.000  1.000  
5000384000 50   Turkey, meat byproducts            0.310000   1.000  1.000  
5000384001 50   Turkey, meat byproducts-babyfood   0.310000   1.000  1.000  
5000385000 50   Turkey, fat                        0.310000   1.000  1.000  
5000385001 50   Turkey, fat-babyfood               0.310000   1.000  1.000  
5000386000 50   Turkey, skin                       0.310000   1.000  1.000  
5000386001 50   Turkey, skin-babyfood              0.310000   1.000  1.000  
6000301000 60   Poultry, other, meat               0.100000   1.000  1.000  
6000302000 60   Poultry, other, liver              0.310000   1.000  1.000  
6000303000 60   Poultry, other, meat byproducts    0.310000   1.000  1.000  
6000304000 60   Poultry, other, fat                0.310000   1.000  1.000  
6000305000 60   Poultry, other, skin               0.310000   1.000  1.000  
7000145000 70   Egg, whole                         0.840000   1.000  1.000  
7000145001 70   Egg, whole-babyfood                0.840000   1.000  1.000  
7000146000 70   Egg, white                         0.840000   1.000  1.000  
7000146001 70   Egg, white (solids)-babyfood       0.840000   1.000  1.000  
7000147000 70   Egg, yolk                          0.840000   1.000  1.000  
7000147001 70   Egg, yolk-babyfood                 0.840000   1.000  1.000  
8000161000 80   Fish-shellfish, crustacean         0.100000   1.000  1.000  
8601000000 86A  Water, direct, all sources         0.207000   1.000  1.000  
8602000000 86B  Water, indirect, all sources       0.207000   1.000  1.000  
9500001000 O    Acerola                            2.000000   1.000  1.000  
9500016000 O    Artichoke, globe                   4.000000   1.000  1.000  
9500019000 O    Asparagus                         13.000000   1.000  1.000  
9500020000 O    Avocado                            4.000000   1.000  1.000  
9500023000 O    Banana                             4.000000   1.000  1.000  
9500023001 O    Banana-babyfood                    4.000000   1.000  1.000  
9500024000 O    Banana, dried                      4.000000   3.900  1.000  
9500024001 O    Banana, dried-babyfood             4.000000   3.900  1.000  
9500073000 O    Cactus                            13.000000   1.000  1.000  
9500074000 O    Canistel                           4.000000   1.000  1.000  
9500089000 O    Cherimoya                          4.000000   1.000  1.000  
9500109000 O    Cocoa bean, chocolate              1.500000   1.000  1.000  
9500110000 O    Cocoa bean, powder                 1.500000   1.000  1.000  
9500111000 O    Coconut, meat                      0.020000   1.000  1.000  
9500111001 O    Coconut, meat-babyfood             0.020000   1.000  1.000  
9500112000 O    Coconut, dried                     0.020000   1.000  1.000  
9500113000 O    Coconut, milk                      0.020000   1.000  1.000  
9500114000 O    Coconut, oil                       0.020000   1.000  1.000  
9500115000 O    Coffee, roasted bean               0.400000   1.000  1.000  
9500116000 O    Coffee, instant                    2.000000   1.000  1.000  
9500151000 O    Feijoa                             4.000000   1.000  1.000  
9500153000 O    Fig                                4.000000   1.000  1.000  
9500154000 O    Fig, dried                         4.000000   1.000  1.000  
9500177000 O    Grape, leaves                      2.400000   1.000  1.000  
9500178000 O    Grape, raisin                      5.000000   1.000  1.000  
9500183000 O    Guava                              4.000000   1.000  1.000  
9500183001 O    Guava-babyfood                     4.000000   1.000  1.000  
9500188000 O    Hop                               90.000000   1.000  1.000  
9500209000 O    Longan                             4.000000   1.000  1.000  
9500211000 O    Lychee                             2.000000   1.000  1.000  
9500212000 O    Lychee, dried                      2.000000   1.850  1.000  
9500215000 O    Mango                              4.000000   1.000  1.000  
9500215001 O    Mango-babyfood                     4.000000   1.000  1.000  
9500216000 O    Mango, dried                       4.000000   1.000  1.000  
9500217000 O    Mango, juice                       4.000000   1.000  1.000  
9500217001 O    Mango, juice-babyfood              4.000000   1.000  1.000  
9500235000 O    Olive                              4.000000   1.000  1.000  
9500236000 O    Olive, oil                        40.000000   1.000  1.000  
9500245000 O    Papaya                             4.000000   1.000  1.000  
9500245001 O    Papaya-babyfood                    4.000000   1.000  1.000  
9500246000 O    Papaya, dried                      4.000000   1.800  1.000  
9500247000 O    Papaya, juice                      4.000000   1.500  1.000  
9500252000 O    Passionfruit                       4.000000   1.000  1.000  
9500252001 O    Passionfruit-babyfood              4.000000   1.000  1.000  
9500253000 O    Passionfruit, juice                4.000000   1.000  1.000  
9500253001 O    Passionfruit, juice-babyfood       4.000000   1.000  1.000  
9500263000 O    Peanut                             0.060000   1.000  1.000  
9500264000 O    Peanut, butter                     0.060000   1.890  1.000  
9500265000 O    Peanut, oil                        0.060000   1.000  1.000  
9500275000 O    Peppermint                         9.000000   1.000  1.000  
9500276000 O    Peppermint, oil                    9.000000   1.000  1.000  
9500277000 O    Persimmon                          4.000000   1.000  1.000  
9500279000 O    Pineapple                          1.500000   1.000  1.000  
9500279001 O    Pineapple-babyfood                 1.500000   1.000  1.000  
9500280000 O    Pineapple, dried                   1.500000   5.000  1.000  
9500281000 O    Pineapple, juice                   1.500000   1.700  1.000  
9500281001 O    Pineapple, juice-babyfood          1.500000   1.700  1.000  
9500283000 O    Plantain                           4.000000   1.000  1.000  
9500284000 O    Plantain, dried                    4.000000   3.900  1.000  
9500289000 O    Pomegranate                        4.000000   1.000  1.000  
9500333000 O    Sapote, Mamey                      4.000000   1.000  1.000  
9500346000 O    Soursop                            4.000000   1.000  1.000  
9500351000 O    Spanish lime                       4.000000   1.000  1.000  
9500352000 O    Spearmint                          9.000000   1.000  1.000  
9500353000 O    Spearmint, oil                     9.000000   1.000  1.000  
9500358000 O    Starfruit                          4.000000   1.000  1.000  
9500361000 O    Sugar apple                        4.000000   1.000  1.000  
9500362000 O    Sugarcane, sugar                  14.000000   1.000  1.000  
9500362001 O    Sugarcane, sugar-babyfood         14.000000   1.000  1.000  
9500363000 O    Sugarcane, molasses              420.000000   1.000  1.000  
9500363001 O    Sugarcane, molasses-babyfood     420.000000   1.000  1.000  
9500372000 O    Tea, dried                        50.000000   1.000  1.000  
9500373000 O    Tea, instant                      50.000000   1.000  1.000  

 Attachment 2: Chronic Food Plus Water Results

U.S. EPA                                                        Ver. 3.16, 03-08-d
DEEM-FCID Chronic analysis for CHLORANTRANILIPROLE         NHANES 2003-2008 2-day
Residue file name: C:\Documents and Settings\krury\My Documents\My Work Files\Chlorantraniliprole\Peanut and Green Onion\DEEM Files\CHLORANTRANILIPROLECHRONIC green onion peanut 110813.R08
                                                 Adjustment factor #2 NOT used.
Analysis Date 11-08-2013/13:26:12     Residue file dated: 11-08-2013/13:25:05
Reference dose (RfD, Chronic) = 1.58 mg/kg bw/day
COMMENT 1: Only a chronic endpoint; there is no acute endpoint
===============================================================================
                    Total exposure by population subgroup
-------------------------------------------------------------------------------

                                                    Total Exposure
                                         -----------------------------------
          Population                         mg/kg             Percent of   
           Subgroup                       body wt/day             Rfd       
--------------------------------------   -------------       ----------------
Total US Population                         0.036207                 2.3%
Hispanic                                    0.039090                 2.5%
Non-Hisp-White                              0.035842                 2.3%
Non-Hisp-Black                              0.033738                 2.1%
Non-Hisp-Other                              0.039447                 2.5%
Nursing Infants                             0.034638                 2.2%
Non-Nursing Infants                         0.072500                 4.6%
Female 13+ PREG                             0.032447                 2.1%
Children 1-6                                0.087507                 5.5%
Children 7-12                               0.042475                 2.7%
Male 13-19                                  0.027688                 1.8%
Female 13-19/NP                             0.026858                 1.7%
Male 20+                                    0.030448                 1.9%
Female 20+/NP                               0.030256                 1.9%
Seniors 55+                                 0.029870                 1.9%
All Infants                                 0.060811                 3.8%
Female 13-50                                0.029395                 1.9%
Children 1-2                                0.105269                 6.7%
Children 3-5                                0.081499                 5.2%
Children 6-12                               0.046110                 2.9%
Youth 13-19                                 0.027234                 1.7%
Adults 20-49                                0.030559                 1.9%
Adults 50-99                                0.030166                 1.9%
Female 13-49                                0.029398                 1.9%

-------------------------------------------------------------------------------
Attachment 3: Structures of Chlorantraniliprole and Possible Metabolites
 
          Structures of Chlorantraniliprole and Possible Metabolites.
Chemical Name; Company Code
                                   Structure
3-Bromo-N-[4-chloro-2-methyl-6-[(methylamino)carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide
Chlorantraniliprole
DPX-E2Y45

                                       
3-Bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxylic acid
IN-DBC80

                                       
2-[3-Bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]-6-chloro-3, 8-dimethyl-4(3H)-quinazolinone
IN-EQW78

                                       
5-Bromo-N-methyl-1H-pyrazole-3-carboxamide
IN-F6L99

                                       
N-[2-(Aminocarbonyl)-4-chloro-6-methylphenyl]-3-bromo-1-(3-chloro-2-pyridinyl)1H-pyrazole-5-carboxamide
IN-F9N04

                                       
2-[3-Bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]-6-chloro-8-methyl-4(3H)-quinazolinone
IN-GAZ70

                                       
3-Bromo-N-[4-chloro-2-[[(hydroxymethyl)amino]carbonyl]-6-methylphenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide
IN-H2H20

                                       
N-[2-Aminocarbonyl]-4-chloro-6-(hydroxymethyl)phenyl]-3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide
IN-HXH40

                                       
3-Bromo-N-[4-chloro-2-(hydroxymethyl)-6-[(methylamino)carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide
IN-HXH44

                                       
2-[3-Bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]-6-chloro-8-(hydroxymethyl)-4(3H)-quinazolinone
IN-K7H29

                                       
3-Bromo-N-[4-chloro-2-(hydroxymethyl)-6-[[(hydroxymethyl)amino)carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide
IN-K9T00

                                       
6-Chloro-1, 2, 3, 4-tetrahydro-2, 4-dioxo-8-quinazolinecarboxylic acid
IN-K9X71

                                       
2-[[[3-Bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]carbonyl]amino]-5-chloro-3-[(methylamino)carbonyl]benzoic acid
IN-KAA24

                                       
2-Amino-5-chloro-3-[(methylamino)carbonyl]benzoic acid
IN-L8F56

                                       
IN-E5F18
                                 Not provided
 

 
                Table A.3.1. Poultry Residue Level Calculations
                                   Commodity
                              Nominal Dose (m/k/d)
                          Average Residue Level (ppm)
                                  Total (ppm)
                                        
                                        
                              Chlorantraniliprole
                                    IN-H2H20
                                    IN-K7H29
                                    IN-GAZ70
                                    IN-F9N04
                                        
                                      Eggs
                                       9
                                     0.296
                                     0.149
                                     0.024
                                     0.139
                                     0.138
                                        
                               Adjusted to 10ppm
                                        
                                     0.329
                                     0.165
                                     0.027
                                     0.154
                                     0.153
                                        
                                   MW Factor
                                        
                                   483/483 =1
                                 483/499 = 0.97
                                 483/467 = 1.03
                                 483/451 = 1.07
                                 483/469 = 1.03
                                        
                       10 Chlorantraniliprole Equivalents
                                        
                                     0.329
                                     0.160
                                     0.028
                                     0.165
                                     0.157
                                      0.84
                                     Liver
                                       9
                                     0.092
                                     0.092
                                      0.06
                                     0.018
                                     0.0153
                                        
                               Adjusted to 10 ppm
                                        
                                     0.102
                                     0.102
                                     0.067
                                      0.02
                                     0.017
                                        
                                   MW Factor
                                        
                                       1
                                      0.97
                                      1.03
                                      1.07
                                      1.03
                                        
                       10 Chlorantraniliprole Equivalents
                                        
                                     0.102
                                     0.099
                                     0.068
                                     0.021
                                     0.018
                                      0.31
                                 Muscle (Meat)
                                       9
                                     0.027
                                     0.028
                                     0.002
                                     0.001
                                     0.031
                                        
                               Adjusted to 10 ppm
                                        
                                      0.03
                                     0.031
                                     0.002
                                     0.001
                                     0.034
                                        
                                   MW Factor
                                        
                                       1
                                      0.97
                                      1.03
                                      1.07
                                      1.03
                                        
                       10 Chlorantraniliprole Equivalents
                                        
                                      0.03
                                     0.302
                                     0.0023
                                     0.0012
                                     0.035
                                      0.10
                                    Skin/Fat
                                       9
                                     0.096
                                     0.068
                                     0.004
                                     0.008
                                     0.103
                                        
                               Adjusted to 10 ppm
                                        
                                     0.107
                                     0.076
                                     0.0044
                                     0.0089
                                      0.11
                                        
                                   MW Factor
                                        
                                       1
                                      0.97
                                      1.03
                                      1.07
                                      1.03
                                        
                       10 Chlorantraniliprole Equivalents
                                        
                                     0.1067
                                     0.073
                                     0.0046
                                     0.0095
                                      0.12
                                      0.31
 1. The day that gives the highest residue value was day 14  -  which was chosen to calculate the residue levels.  Using only average values as this is a chronic dietary analysis.  For additional details see D407350; D410513; D412173.

 
               Table A.3.2 Ruminant Residue Level Calculations[1]
                                   Commodity
                              Nominal Dose (m/k/d)
                          Average Residue Level (ppm)
                            Current Tolerance (ppm)
                                        
                                        
                              Chlorantraniliprole
                                    IN-HXH44
                                    IN-K9T00
                                  Total (ppm)
                                        
                                      Milk
                                       50
                                     0.027
                                      0.03
                                     0.012
                                        
                                        
                               Adjusted to 80ppm
                                        
                                     0.043
                                     0.048
                                     0.019
                                        
                                        
                                   MW Factor
                                        
                                  483/483 = 1
                                 483/499 = 0.97
                                 483/515 = 0.94
                                        
                                        
                       10 Chlorantraniliprole Equivalents
                                        
                                     0.043
                                     0.047
                                     0.018
                                      0.11
                                      0.1
                                     Liver
                                        
                                      0.13
                                     0.045
                                     0.005
                                        
                                        
                              Adjusted to 115 ppm
                                       50
                                     0.299
                                     0.104
                                     0.012
                                        
                                        
                                   MW Factor
                                        
                                       1
                                      0.97
                                      0.94
                                        
                                        
                       10 Chlorantraniliprole Equivalents
                                        
                                     0.299
                                     0.1003
                                     0.012
                                      0.41
                                      0.5
                                     Kidney
                                       50
                                     0.068
                                     0.039
                                     0.012
                                        
                                        
                              Adjusted to 115 ppm
                                        
                                     0.1564
                                     0.0897
                                     0.0276
                                        
                                        
                                   MW Factor
                                        
                                       1
                                      0.97
                                      0.94
                                        
                                        
                       10 Chlorantraniliprole Equivalents
                                        
                                     0.1564
                                    0.087009
                                    0.025844
                                      0.27
                                      0.5
                                      Fat
                                       50
                                      0.14
                                     0.012
                                       0
                                        
                                        
                              Adjusted to 115 ppm
                                        
                                     0.322
                                     0.0276
                                       0
                                        
                                        
                                   MW Factor
                                        
                                       1
                                      0.97
                                      0.94
                                        
                                        
                       10 Chlorantraniliprole Equivalents
                                        
                                     0.322
                                    0.026772
                                       0
                                      0.35
                                      0.5
                                 Meat (muscle)
                                       50
                                     0.019
                                     0.009
                                       0
                                        
                                        
                              Adjusted to 115 ppm
                                        
                                     0.0437
                                     0.0207
                                       0
                                        
                                        
                                   MW Factor
                                        
                                       1
                                      0.97
                                      0.94
                                        
                                        
                       10 Chlorantraniliprole Equivalents
                                        
                                     0.0437
                                    0.020079
                                       0
                                      0.06
                                      0.1
 1. The latest ruminant burden levels are 80 ppm for diary cattle and 115 ppm for beef cattle (D404708, 09/10/2013).  The highest feeding level was 50 ppm (Monograph B7, IIA.B.7.8.1, page 700 ff).  
 
