
                    UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
                               WASHINGTON, D.C.  20460
                                       
              Office of Chemical Safety and Pollution Prevention

MEMORANDUM

Date:		15-January-2015

Subject:	Difenoconazole.  Acute and Chronic Aggregate Dietary Exposure and Risk Assessments for the Petition for Use of Difenoconazole on Rapeseed Crop Subgroup 20A and Imported Dragonfruit.
				
PC Code:  	128847
DP Barcode:	412812 & 422170
Decision No.: 473631 & 493233
Registration No.:  100-1262
Petition Nos.:  2F8134 & 4E8296
Regulatory Action:  Amended Section 3
Assessment Type:  Single Chemical, Dietary 
Registration Case No.:  NA
TXR No.:  None
CAS No.:  119446-68-3
MRID No.:  None
40 CFR: 180.475

Reviewer:	Thurston G. Morton, Chemist
          Risk Assessment Branch IV/Health Effects Division (RABIV/HED; 7509P)

Through:    Tom Bloem, Chemist
			 William Cutchin, Chemist
          Dietary Exposure Science Advisory Council (DESAC)
         
         	And
         
         Elissa Reaves PhD., Branch Chief
         RABIV/HED (7509P)

To:			Thurston G. Morton, Risk Assessor
         RABIV/HED (7509P)
         
         	And
         
   Rosemary Kearns/Tony Kish (RM 22)
	      Fungicide Branch
         Registration Division (7505P)






Executive Summary

Difenoconazole acute and chronic dietary exposure and risk assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM-FCID) Version 3.16.  This software uses 2003-2008 food consumption data from the U.S. Department of Agriculture's (USDA's) National Health and Nutrition Examination Survey, What We Eat in America, (NHANES/WWEIA).   This dietary survey was conducted from 2003 to 2008.  The analyses were performed to support the Section 3 registration on Rapeseed Crop Subgroup 20A of the fungicide difenoconazole [1-[2-[2-chloro-4-(4-chlorophenoxy)phenyl]-4-methyl-1,3-dioxolan-2-ylmethyl]-1H-1,2,4-triazole] and the use of difenoconazole on imported dragonfruit.  

This memorandum was reviewed by two peer reviewers of the DESAC, per DESAC SOP 2012.1. 

The unrefined acute analysis assumed tolerance-level residues, 100% crop treated (CT), and the available empirical or DEEM (ver. 7.81) default processing factors.  The somewhat refined chronic analysis assumed tolerance-level residues for some commodities, average field trial residues for the majority of commodities, the available empirical or DEEM (ver. 7.81) default processing factors, and 100 % CT.  The EDWC of 20.0 μg/L (ppb) was used for the acute dietary exposure analysis and an estimated drinking water concentrations (EDWC)  of 13.6 μg/L (ppb) was used for the chronic dietary exposure analysis.

The resulting acute food plus water exposure estimates were less than HED's level of concern ( - <100% of the acute population-adjusted dose (aPAD)) at the 95[th] percentile of the exposure distribution for the general U.S. population (12 % aPAD) and all population sub-groups; the most highly exposed population subgroup was children1-2 years old with 27 % aPAD.  The resulting chronic food plus water exposure estimates were less than HED's level of concern ( - <100% of the chronic population-adjusted dose (cPAD)) for the general U.S. population (30 % cPAD) and all population sub-groups; the most highly exposed population subgroup was children 1 - 2 years old with 75 % cPAD.  No cancer analysis was performed since it was determined the chronic dietary exposure assessment is protective of cancer effects. 

The dietary exposure analyses for the triazole metabolites were updated (D414951, T. Morton, 24 Oct. 2013).











I.   Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide.  For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health effects).  This dose is referred to as the PAD.  The PAD is equivalent to the point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD.  HED is generally concerned when estimated cancer risk exceeds one in one million.  References which discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site:  "Available Information on Assessing Exposure from Pesticides, A User's Guide," 21-JUN-2000, web link:  http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf; or see SOP 99.6 (20-AUG-1999).

The most recent dietary risk assessment for difenoconazole was conducted by T. Morton (30-May-2012; DP#397664).

II.   Residue Information

Difenoconazole tolerances are published in 40 CFR§180.475.

Residues of Concern in Plants and Livestock:   

Residues of concern were determined based on recommendations from the HED Residues of Concern Knowledgebase Sub-committee (ROCKS) (D391350, 9/19/11).  The residue of concern for plant commodities for tolerance expression and risk assessment purposes is difenoconazole per se.  The HED ROCKS has determined that the parent compound and the CGA-205375 metabolite are the residues of concern in livestock commodities for both the tolerance expression and the risk assessment. In addition, metabolite OH-CGA-169374, which comprised 15% of the TRR in goat milk from the phenyl-labeled study, should be considered as a residue of concern for the dietary risk assessment.  Based on available goat metabolism data, total residues of concern in milk for dietary risk assessments (parent, CGA-205375, and OH-CGA-169374), should be calculated by multiplying the tolerance in milk by a factor of 1.5x.  Table 1 summarizes tolerance expression and the residues of concern in plant and livestock commodities.

Table 1.  Difenoconazole Residues of Concern in Plants and Ruminants.
                                    Matrix
                              Residues of Concern

                              For Risk Assessment
                           For Tolerance Expression
Plants
Primary and Rotational crops
                                  Parent Only
                                  Parent Only
Livestock
Ruminant and Poultry
                             Parent and CGA 205375
                             Parent and CGA 205375

Milk
                     Parent, CGA 205375 and OH-CGA-169374
                             Parent and CGA 205375
Drinking Water
                                  Parent Only
                                      NA
Note:  The triazole-containing metabolites 1,2,4-T, TA, and TAA should be included in the residues of concern for risk assessment purposes only for plant and livestock commodities.  Since these metabolites are common to the entire class of traizole-derivative fungicides and because of differential toxicity between metabolites and the various parent compounds, risks associated with exposure to 1,2,4-T and to TA/TAA are addressed separately.

Recommended Tolerances:  Based on the residue chemistry data submitted with the previous petitions, HED recommended for establishment of the new food tolerances (DP# 412810, B. Cropp-Kohlligian, 22-August-2013).  The recommended, established, and revised tolerances are listed in Table 2 below.

Table 2.  Tolerance Summary for Difenoconazole (non feed items).
Commodity
                     Existing/Established Tolerances (ppm)
                             New Tolerances (ppm)
Rapeseed crop subgroup 20A
                                     -----
                                     0.10
Almond, nutmeat
                                     0.03
                                    ------
Brassica subgroup 5A
                                      1.9
                                    ------
Brassica subgroup 5B
                                      35
                                    ------
Citrus oil
                                      25
                                    ------
Fruit, citrus, group 10
                                      0.6
                                    ------
Grape
                                      4.0
                                    ------
Grape, raisin
                                      6.0
                                    ------
Nut, tree, group 14
                                     0.03
                                    ------
Onion, bulb, subgroup 3 -- 07A
                                     0.20
                                    ------
Onion, green, subgroup 3 -- 07B
                                      6.0
                                    ------
Pistachios
                                     0.03
                                    ------
Vegetable, cucurbit, group 9
                                      0.7
                                    ------
Fruit, Pome, group 11
                                      1.0
                                    ------
Vegetable, Fruiting, Group 8
                                     0.60
                                    ------
Vegetable, Tuberous and Corm, subgroup 1C
                                      4.0
                                      4.0
Beet, sugar
                                     0.30
                                    ------
Papaya
                                     0.30
                                    ------
Banana
                                      0.2
                                    ------
Barley, grain
                                      0.1
                                    ------
Canola, seed
                                     0.01
                                    ------
Cattle fat
                                     0.10
                                    ------
Cattle, meat
                                     0.05
                                    ------
Cattle, meat byproducts
                                     0.10
                                    ------
Cattle, liver
                                     0.40
                                    ------
Corn, sweet, kernel plus cob with husks removed
                                     0.01
                                    ------
Cotton, undelinted seed
                                     0.05
                                    ------
Egg
                                     0.02
                                    ------
Goat, fat
                                     0.10
                                    ------
Goat, meat
                                     0.05
                                    ------
Goat, meat byproducts (except liver)
                                     0.10
                                    ------
Goat, liver
                                     0.40
                                    ------
Hog, fat
                                     0.10
                                    ------
Hog, meat
                                     0.05
                                    ------
Hog, meat byproducts (except liver)
                                      0.1
                                    ------
Hog, liver
                                     0.40
                                    ------
Horse, fat
                                     0.10
                                    ------
Horse, meat
                                     0.05
                                    ------
Horse, meat byproducts (except liver)
                                     0.10
                                    ------
Horse, liver
                                     0.40
                                    ------
Milk
                                     0.01
                                    ------
Rye, grain
                                     0.01
                                    ------
Sheep, fat
                                     0.10
                                    ------
Sheep, meat
                                     0.05
                                    ------
Sheep, meat byproducts (except liver)
                                     0.10
                                    ------
Sheep, liver
                                     0.40
                                    ------
Wheat, grain
                                      0.1
                                    ------
Wax apple
                                     0.07
                                    ------
Mango
                                     0.07
                                    ------
Carrot
                                     0.50
                                    ------
Chickpea
                                     0.08
                                    ------
Soybean, seed
                                     0.15
                                    ------
Fruit, stone, group 12
                                      2.5
                                    ------
Strawberry
                                      2.5
                                    ------
Turnip greens
                                      35
                                    ------
Oat, grain
                                     0.01
                                    ------
Wax Jambu
                                      1.5
                                       
Dragonfruit
                                       
                        1.5 (translated from wax jambu)

The dietary exposure analyses for the triazole metabolites (D414951, T. Morton, 24 Oct. 2013) was updated.

Food Residues and processing factors used in the Acute and Chronic Analysis:  The acute analysis assumed tolerance-level residues and 100% CT for all the registered and proposed crops.  Tolerance-level residues were also assumed for all livestock tissues in this assessment.  The chronic analysis assumed tolerance-level residues for some commodities, average field trial residues for the majority of commodities, and 100 % CT.  Those commodities where field trial data were used are summarized below.  HED SOP 2000.1 Guidance for Translation of Field Trial Data from Representative Commodities in the Crop Group Regulation to Other Commodities in Each Crop Group/Subgroup dated 9/12/2000 was used in translating to other commodities in the crop group.  Experimental processing factors were used for apple juice (0.04x), grape juice (0.2x), citrus juices (0.1x), potato chips (0.5x), potato granules/flakes (0.5x), raisin (3.5x chronic only since the raisin tolerance was used in acute), sugar beet molasses (0.6x), tomato paste (1.6x), and tomato puree (0.5x); DEEM (ver. 7.81) default processing factors were assumed for other processed commodities.  

Almond: Field trial residues were used from MRID 47586101.  

Apple: Field trial residues were used from MRID 46950233.

Broccoli: Field trial residues were used from MRID 47586102.  Residues from 1-7 day PHI were used since registered labels allow from 1-7 day PHIs.

Cabbage:  Field trial residues were used from 47586102.  Residues from 1-7 day PHI were used since registered labels allow from 1-7 day PHIs.  To refine the dietary exposure data from only cabbage samples without wrapper leaves were used.

Cantaloupe: Field trial residues were used from MRID 47586103.  Residues from 0-1 day PHI were used since registered labels allow from 0-1 day PHI.

Carrot: Field trial residues were used from MRID 47929804.

Chickpea: Field trial residues were used from MRID 47929805.

Cucumber: Field trial residues were used from MRID 47586103.  Residues from 0-1 day PHI were used since registered labels allow from 0-1 day PHI.

Grape: Field trial residues were used from MRID 47586105.

Grapefruit: Field trial residues were used from MRID 47586104.

Lemon: Field trial residues were used from MRID 47586104.

Lime: Field trial residues were used from MRID 47586104.

Mustard Greens: Field trial residues were used from MRIDs 47417704, 47417707, and 47586102.  Residues from 1-7 day PHI were used since registered labels allow from 1-7 day PHIs.

Orange: Field trial residues were used from MRID 47586104.

Pear: Field trial residues were used from MRID 46950233.

Pecan: Field trial residues were used from MRID 47586106.

Peppers: Field trial residues were used from MRID 46950234.

Potato: Field trial residues were used from MRID 47929804.

Soybean: Field trial residues were used from MRID 47929801.

Stone Fruit: Field trial residues were used from MRID 47929803.

Strawberry: Field trial residues were used from MRID 47929802.

Sugar Beet: Field trial residues were used from MRID 46950236.

Summer Squash: Field trial residues were used from MRID 47586103.  Residues from 0-1 day PHI were used since registered labels allow from 0-1 day PHIs.

Tomato: Field trial residues were used from MRIDs 46950234, 47417705, and 47417708.

III.  Percent Crop Treated Information

The acute and chronic dietary exposure analyses assumed 100% crop treated (CT).

IV.  Drinking Water Data

The drinking water estimates used in the dietary risk assessment were provided by the Environmental Fate and Effects Division (EFED; Memo, F. Khan, 14-August-2013; D412614).  For surface water, the EDWCs for canola/ oilseed subgroup 20A did not exceed the peak (acute) concentration of 17.4 ug/L, annual mean (non-cancer chronic) concentration of 11.8 ug/L and the 30 year annual average concentration (cancer chronic) of 8.6 ug/L for use on grape reported in the previous drinking water assessment (US EPA, 2012b; DP 398836 ). Therefore, the EDWCs for surface water for canola/ oilseed subgroup 20A (Table 1) did not supersede the previously recommended drinking water concentrations.  However, the previously recommended EDWCs were based on 0.87 PCA (Percent Cropped Area) factor. Recently, EFED implemented a revised guidance for PCA (USEPA 2012a). Since difenoconazole can be used in both non-agricultural (turf) and various agricultural crops, a PCA of 1.0 factor was used to revise previously recommended EDWCs for grape. For surface water, revised recommended EDWCs are 20.0 ug/L for peak, 13.6 ug/L for annual mean and 9.9ug/L for annual average concentrations
Estimated PZRM-GW ground water acute concentration of 2.24 ug/L and chronic concentration of 0.82 ug/L are higher than the previously recommended concentration of 1.30x 10[-2] ug/L for citrus (US EPA, 2011; D395784). Therefore, the current EDWCs superseded the previously recommended EDWCs for groundwater.  Recommended EDWCs for human health are 20.0 μg/L (ppb) for the acute dietary (food plus water) exposure analysis and the 1-in-10 year annual mean EDWC of 13.6 μg/L (ppb) for the chronic dietary (food plus water) exposure analysis.

V.  DEEM-FCID Program and Consumption Information

Difenoconazole acute and chronic dietary exposure assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database DEEM-FCID(TM), Version 3.16, which incorporates consumption data from USDA's National Health and Nutrition Examination Survey, What We Eat in America, (NHANES/WWEIA).  This dietary survey was conducted from 2003 to 2008.  The data are based on the reported consumption of more than 20,000 individuals over two non-consecutive survey days.  Foods "as consumed" (e.g., apple pie) are linked to EPA-defined food commodities (e.g. apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA.  For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups, but for acute exposure assessment are retained as individual consumption events.  Based on analysis of the 2003-2008 WWEIA consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50-99 years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or food-form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food form.  The resulting residue consumption estimate for each food/food form is summed with the residue consumption estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure.  Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD.  This procedure is performed for each population subgroup.

For acute exposure assessments, individual one-day food consumption data are used on an individual-by-individual basis.  The reported consumption amounts of each food item can be multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or "matched" in multiple random pairings with residue values and then summed in a probabilistic assessment.  The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., those who reported eating relevant commodities/food forms) and a per-capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis.  In accordance with HED policy, per capita exposure and risk are reported for all tiers of analysis.  However, for Tiers 1 and 2, significant differences in user vs. per capita exposure and risk are identified and noted in the risk assessment.

VI.  Toxicological Information

On 08-SEP-1998, HED's Hazard Identification Assessment Review Committee (HIARC) evaluated the toxicology database of difenoconazole and re-assessed the RfD established in 1994, as well as the toxicological endpoints for the dietary and occupational exposure risk assessments that were selected in 1994.  At this meeting, the HIARC also addressed the potential enhanced sensitivity of infants and children from exposure to difenoconazole as required by the Food Quality Protection Act (FQPA) of 1996 (HED Doc. No. 012873, 25-SEP-1998).  In July, 2007, the RAB1 toxicologists and risk assessment team met to reevaluate the endpoints selected by the HIARC since new studies were submitted.  RAB1 toxicologists and risk assessment team also reevaluated FQPA assessments.  The risk assessment team concluded that the default 10x FQPA Safety Factor (SF) should be reduced to 1x when assessing acute and chronic dietary exposures (M.Sahafeyan, D333320, 09-AUG-07).  The relevant endpoints are shown in Table 3.

In accordance with HED's current policy and EPA's 2005 Cancer Guidelines, difenoconazole is classified as "Suggestive Evidence of Carcinogenic Potential," based on excessive toxicity observed at the two highest doses, the absence of tumors at the lower doses and the absence of genotoxic effects.   A margin-of-exposure (MOE) approach in risk assessment was advocated by HED's  CPRC in 1994.  Use of an MOE approach was reviewed and reaffirmed in 2007 by the CPRC Chair (PV Shah, 3/1/07, HED Doc. No. 0054532).  Therefore, a separate cancer dietary assessment is not being conducted for difenoconazole.

Table 3.  Summary of Toxicological Doses and Endpoints for Difenoconazole for Use in Dietary Risk Assessments.  
                               Exposure Scenario
                              Point of Departure
                        Uncertainty/FQPA Safety Factors
                         RfD, PAD, for Risk Assessment
                   Study and Relevant Toxicological Effects
Acute Dietary (All populations)
NOAEL = 25
mg/kg
UFA = 10X
UFH = 10X
FQPA SF = 1X 
aRfD = aPAD = 0.25 mg/kg/day
Acute Neurotoxicity Study in Rats
LOAEL= 200 mg/kg in males based on reduced fore-limb grip strength in males on day 1.
Chronic Dietary (All populations)
NOAEL = 0.96
mg/kg/day
UFA = 10X
UFH = 10X
FQPA SF = 1X
cRfD = cPAD = 0.01mg/kg/day
Combined chronic toxicity/carcinogenicity (rat; dietary) LOAEL = 24.1/32.8 mg/kg/day (M/F) based on cumulative decreases in body-weight gains.
Cancer (oral, dermal, inhalation)
Difenoconazole is classified as a Group C, possible human carcinogen with a non-linear (MOE) approach for human risk characterization (CPRC Document, 7/27/94, Memo, P. V. Shah dated March 3, 2007, HED Doc. No. 0054532). The chronic dietary exposure assessment is protective of cancer effects.
Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and  used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures.  NOAEL = no observed adverse effect level.  LOAEL = lowest observed adverse effect level.  UF = uncertainty factor.  UFA = extrapolation from animal to human (interspecies).  UFH = potential variation in sensitivity among members of the human population (intraspecies).  FQPA SF = FQPA Safety Factor.  PAD = population adjusted dose (a = acute, c = chronic).  RfD = reference dose.   

VII.  Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the aPAD or cPAD, respectively.  The following paragraphs are summaries of the DEEM-FCID (ver. 2.03) acute and chronic exposure analyses.

Acute and chronic aggregate (food + water) analyses were performed using DEEM-FCID estimating the dietary exposure of the U.S. population and various population subgroups.  The results are summarized in Tables 4 and 5 below for acute and chronic analyses respectively.  

The resulting acute food exposure estimates were less than HED's level of concern ( - <100% aPAD) at the 95[th] percentile of the exposure distribution for general US population (11 % aPAD) and all population sub-groups; the most highly exposed population subgroup was Children 1-2 years old with 29 % aPAD.  The resulting chronic food exposure estimates were less than HED's level of concern ( - <100% cPAD) for the general U.S. population (27 % cPAD) and all population sub-groups; the most highly exposed population subgroup was children 1-2 years old with 78 % cPAD.   A separate cancer dietary assessment was not conducted for difenoconazole because the cancer NOAEL is higher than the chronic RfD; therefore, the chronic dietary risk estimate is considered protective of all chronic effects including carcinogenicity.



Table 4.  Summary of Acute Dietary (Food plus Water) Exposure and Risk for Difenoconazole at the 95[th] Percentile. 

Population Subgroup

                               aPAD (mg/kg/day)

                             Exposure (mg/kg/day)

                                     %aPAD

General U.S. Population






                                     0.25

                                   0.028053
                                      11

All Infants (< 1 year old)


                                   0.056908
                                      23

Children 1-2 years old


                                   0.071431
                                      29

Children 3-5 years old


                                   0.050407
                                      20

Children 6-12 years old


                                   0.033218
                                      13

Youth 13-19 years old

                                   0.017774
                                      7.1

Adults 20-49 years old 


                                   0.020285
                                      8.1

Adults 50-99 years old 


                                   0.023527
                                      9.4

Females 13-49 years old 


                                   0.020231
                                      8.1
The bolded %aPAD is the highest.



Table 5.  Summary of Chronic Dietary (Food plus Water) Exposure and Risk for Difenoconazole. 

Population Subgroup

                               cPAD (mg/kg/day)

                             Exposure (mg/kg/day)

                                     %cPAD

General U.S. Population






                                     0.01

                                   0.002685
                                      27

All Infants (< 1 year old)


                                   0.004796
                                      48

Children 1-2 years old


                                   0.007816
                                      78

Children 3-5 years old


                                   0.005781
                                      58

Children 6-12 years old


                                   0.003616
                                      36

Youth 13-19 years old


                                   0.002069
                                      21

Adults 20-49 years old 


                                   0.002144
                                      21

Adults 50-99 years old 


                                   0.002348
                                      24

Females 13-49 years old 


                                   0.002092
                                      21
The bolded %cPAD is the highest.
  

VIII.  Characterization of Inputs/Outputs

The acute analysis assumed tolerance-level residues, 100% CT, and empirical or DEEM default processing factors.  The chronic analysis assumed tolerance-level residues for some commodities, average field trial residues for the majority of commodities, 100 % CT, and empirical or DEEM default processing factors.  Therefore, these analyses are considered conservative.  While they could be significantly refined, further refinement is not warranted as estimated risks are not of concern.  
 IX.  Conclusions

An acute aggregate (food + water) dietary risk assessment was conducted for difenoconazole using the DEEM-FCID (ver. 2.03) Model and assumed tolerance-level residues, 100% CT, and empirical or DEEM default processing factors.  The chronic aggregate dietary risk assessment assumed tolerance-level residues for some commodities, average field trial residues for the majority of commodities, 100 % CT, and empirical or DEEM default processing factors.  The resulting acute and chronic aggregate exposure estimates were less than HED's level of concern.  For the general U.S. population, the aPAD and cPAD were 11 % and 27 %, respectively.  The most highly-exposed population subgroups in the acute (at the 95[th] percentile of the exposure distribution) and chronic analyses were Children 1-2 years old (29 % aPAD) and children 1-2 years old (78 % cPAD), respectively.  







 X.  List of Attachments

Attachment 1:	DEEM-FCID Acute Residue File
Attachment 2:	DEEM-FCID Acute Exposure Estimates
Attachment 3:	DEEM-FCID Chronic Residue File
Attachment 4:	DEEM-FCID Chronic Exposure Estimates

cc with all attachments:  T. Morton (RABIV)
RDI: T. Bloem and W. Cutchin - DESAC (26-January-2013); E. Reaves (30-May-2012)
Petition Number(s): 2F8134
PC Code: 128847
T. Morton:S10838:PY1:(703)305-6691

                                       
Attachment 1:  DEEM-FCID Acute Residue File
                                       
Filename: C:\Documents and Settings\tmorton\My Documents\MyFiles\DEEM Files\128847 Difenoconazole\Petition 2F8134 Oilseeds 20A\128847 Acute Aug 2013.R08
Chemical: Difenoconazole
RfD(Chronic): .01 mg/kg bw/day  NOEL(Chronic): 0 mg/kg bw/day
RfD(Acute): .25 mg/kg bw/day  NOEL(Acute):  0 mg/kg bw/day
Date created/last modified: 09-25-2013/08:08:55       Program ver. 3.16, 03-08-d
-----------------------------------------------------------------------------------
   EPA     Crop                                   Def Res     Adj.Factors   Comment
   Code     Grp  Commodity Name                    (ppm)       #1    #2   
---------- ---- -------------------------------  ----------  ------ ------  -------
0101052000 1A   Beet, sugar                        0.300000   1.000  1.000  
0101052001 1A   Beet, sugar-babyfood               0.300000   1.000  1.000  
0101053000 1A   Beet, sugar, molasses              0.300000   0.600  1.000  
0101053001 1A   Beet, sugar, molasses-babyfood     0.300000   0.600  1.000  
0101078000 1AB  Carrot                             0.500000   1.000  1.000  
0101078001 1AB  Carrot-babyfood                    0.500000   1.000  1.000  
0101079000 1AB  Carrot, juice                      0.500000   1.000  1.000  
0103015000 1CD  Arrowroot, flour                   4.000000   1.000  1.000  
0103015001 1CD  Arrowroot, flour-babyfood          4.000000   1.000  1.000  
0103017000 1CD  Artichoke, Jerusalem               4.000000   1.000  1.000  
0103082000 1CD  Cassava                            4.000000   1.000  1.000  
0103082001 1CD  Cassava-babyfood                   4.000000   1.000  1.000  
0103139000 1CD  Dasheen, corm                      4.000000   1.000  1.000  
0103166000 1CD  Ginger                             4.000000   1.000  1.000  
0103166001 1CD  Ginger-babyfood                    4.000000   1.000  1.000  
0103167000 1CD  Ginger, dried                      4.000000   1.000  1.000  
0103296000 1C   Potato, chips                      4.000000   0.500  1.000  
0103297000 1C   Potato, dry (granules/ flakes)     4.000000   0.500  1.000  
0103297001 1C   Potato, dry (granules/ flakes)-b   4.000000   0.500  1.000  
0103298000 1C   Potato, flour                      4.000000   0.500  1.000  
0103298001 1C   Potato, flour-babyfood             4.000000   0.500  1.000  
0103299000 1C   Potato, tuber, w/peel              4.000000   1.000  1.000  
0103299001 1C   Potato, tuber, w/peel-babyfood     4.000000   1.000  1.000  
0103300000 1C   Potato, tuber, w/o peel            4.000000   1.000  1.000  
0103300001 1C   Potato, tuber, w/o peel-babyfood   4.000000   1.000  1.000  
0103366000 1CD  Sweet potato                       4.000000   1.000  1.000  
0103366001 1CD  Sweet potato-babyfood              4.000000   1.000  1.000  
0103371000 1CD  Tanier, corm                       4.000000   1.000  1.000  
0103387000 1CD  Turmeric                           4.000000   1.000  1.000  
0103406000 1CD  Yam, true                          4.000000   1.000  1.000  
0103407000 1CD  Yam bean                           4.000000   1.000  1.000  
0301165000 3A   Garlic, bulb                       0.200000   1.000  1.000  
0301165001 3A   Garlic, bulb-babyfood              0.200000   1.000  1.000  
0301237000 3A   Onion, bulb                        0.200000   1.000  1.000  
0301237001 3A   Onion, bulb-babyfood               0.200000   1.000  1.000  
0301238000 3A   Onion, bulb, dried                 0.200000   9.000  1.000  
0301238001 3A   Onion, bulb, dried-babyfood        0.200000   9.000  1.000  
0301338000 3A   Shallot, bulb                      0.200000   1.000  1.000  
0302103000 3B   Chive, fresh leaves                6.000000   1.000  1.000  
0302198000 3B   Leek                               6.000000   1.000  1.000  
0302239000 3B   Onion, green                       6.000000   1.000  1.000  
0302338500 3B   Shallot, fresh leaves              6.000000   1.000  1.000  
0501061000 5A   Broccoli                           1.900000   1.000  1.000  
0501061001 5A   Broccoli-babyfood                  1.900000   1.000  1.000  
0501062000 5A   Broccoli, Chinese                  1.900000   1.000  1.000  
0501064000 5A   Brussels sprouts                   1.900000   1.000  1.000  
0501069000 5A   Cabbage                            1.900000   1.000  1.000  
0501071000 5A   Cabbage, Chinese, napa             1.900000   1.000  1.000  
0501072000 5A   Cabbage, Chinese, mustard          1.900000   1.000  1.000  
0501083000 5A   Cauliflower                        1.900000   1.000  1.000  
0501196000 5A   Kohlrabi                           1.900000   1.000  1.000  
0502063000 5B   Broccoli raab                     35.000000   1.000  1.000  
0502070000 5B   Cabbage, Chinese, bok choy        35.000000   1.000  1.000  
0502117000 5B   Collards                          35.000000   1.000  1.000  
0502194000 5B   Kale                              35.000000   1.000  1.000  
0502229000 5B   Mustard greens                    35.000000   1.000  1.000  
0502318000 5B   Rape greens                       35.000000   1.000  1.000  
0502389000 5B   Turnip, greens                    35.000000   1.000  1.000  
0600347000 6    Soybean, seed                      0.150000   1.000  1.000  
0600349000 6    Soybean, soy milk                  0.150000   1.000  1.000  
0600349001 6    Soybean, soy milk-babyfood or in   0.150000   1.000  1.000  
0600350000 6    Soybean, oil                       0.150000   1.000  1.000  
0600350001 6    Soybean, oil-babyfood              0.150000   1.000  1.000  
0601349500 6AB  Soybean, vegetable                 0.150000   1.000  1.000  
0603098000 6C   Chickpea, seed                     0.080000   1.000  1.000  
0603098001 6C   Chickpea, seed-babyfood            0.080000   1.000  1.000  
0603099000 6C   Chickpea, flour                    0.080000   1.000  1.000  
0603348000 6C   Soybean, flour                     0.150000   1.000  1.000  
0603348001 6C   Soybean, flour-babyfood            0.150000   1.000  1.000  
0801374000 8A   Tomatillo                          0.600000   1.000  1.000  
0801375000 8A   Tomato                             0.600000   1.000  1.000  
0801375001 8A   Tomato-babyfood                    0.600000   1.000  1.000  
0801376000 8A   Tomato, paste                      0.600000   1.600  1.000  
0801376001 8A   Tomato, paste-babyfood             0.600000   1.600  1.000  
0801377000 8A   Tomato, puree                      0.600000   0.500  1.000  
0801377001 8A   Tomato, puree-babyfood             0.600000   0.500  1.000  
0801378000 8A   Tomato, dried                      0.600000  14.300  1.000  
0801378001 8A   Tomato, dried-babyfood             0.600000  14.300  1.000  
0801379000 8A   Tomato, juice                      0.600000   1.500  1.000  
0802148000 8BC  Eggplant                           0.600000   1.000  1.000  
0802234000 8BC  Okra                               0.600000   1.000  1.000  
0802270000 8B   Pepper, bell                       0.600000   1.000  1.000  
0802270001 8B   Pepper, bell-babyfood              0.600000   1.000  1.000  
0802271000 8B   Pepper, bell, dried                0.600000   1.000  1.000  
0802271001 8B   Pepper, bell, dried-babyfood       0.600000   1.000  1.000  
0802272000 8BC  Pepper, nonbell                    0.600000   1.000  1.000  
0802272001 8BC  Pepper, nonbell-babyfood           0.600000   1.000  1.000  
0802273000 8BC  Pepper, nonbell, dried             0.600000   1.000  1.000  
0901075000 9A   Cantaloupe                         0.700000   1.000  1.000  
0901187000 9A   Honeydew melon                     0.700000   1.000  1.000  
0901399000 9A   Watermelon                         0.700000   1.000  1.000  
0901400000 9A   Watermelon, juice                  0.700000   1.000  1.000  
0902021000 9B   Balsam pear                        0.700000   1.000  1.000  
0902088000 9B   Chayote, fruit                     0.700000   1.000  1.000  
0902102000 9B   Chinese waxgourd                   0.700000   1.000  1.000  
0902135000 9B   Cucumber                           0.700000   1.000  1.000  
0902308000 9B   Pumpkin                            0.700000   1.000  1.000  
0902309000 9B   Pumpkin, seed                      0.700000   1.000  1.000  
0902356000 9B   Squash, summer                     0.700000   1.000  1.000  
0902356001 9B   Squash, summer-babyfood            0.700000   1.000  1.000  
0902357000 9B   Squash, winter                     0.700000   1.000  1.000  
0902357001 9B   Squash, winter-babyfood            0.700000   1.000  1.000  
1001106000 10A  Citron                             0.600000   1.000  1.000  
1001107000 10A  Citrus hybrids                     0.600000   1.000  1.000  
1001108000 10A  Citrus, oil                       25.000000   1.000  1.000  
1001240000 10A  Orange                             0.600000   1.000  1.000  
1001241000 10A  Orange, juice                      0.600000   0.100  1.000  
1001241001 10A  Orange, juice-babyfood             0.600000   0.100  1.000  
1001242000 10A  Orange, peel                       0.600000   1.000  1.000  
1001369000 10A  Tangerine                          0.600000   1.000  1.000  
1001370000 10A  Tangerine, juice                   0.600000   0.100  1.000  
1002197000 10B  Kumquat                            0.600000   1.000  1.000  
1002199000 10B  Lemon                              0.600000   1.000  1.000  
1002200000 10B  Lemon, juice                       0.600000   0.100  1.000  
1002200001 10B  Lemon, juice-babyfood              0.600000   0.100  1.000  
1002201000 10B  Lemon, peel                        0.600000   1.000  1.000  
1002206000 10B  Lime                               0.600000   1.000  1.000  
1002207000 10B  Lime, juice                        0.600000   0.100  1.000  
1002207001 10B  Lime, juice-babyfood               0.600000   0.100  1.000  
1003180000 10C  Grapefruit                         0.600000   1.000  1.000  
1003181000 10C  Grapefruit, juice                  0.600000   0.100  1.000  
1003307000 10C  Pummelo                            0.600000   1.000  1.000  
1100007000 11   Apple, fruit with peel             1.000000   1.000  1.000  
1100008000 11   Apple, peeled fruit                1.000000   1.000  1.000  
1100008001 11   Apple, peeled fruit-babyfood       1.000000   1.000  1.000  
1100009000 11   Apple, dried                       1.000000   8.000  1.000  
1100009001 11   Apple, dried-babyfood              1.000000   8.000  1.000  
1100010000 11   Apple, juice                       1.000000   0.040  1.000  
1100010001 11   Apple, juice-babyfood              1.000000   0.040  1.000  
1100011000 11   Apple, sauce                       1.000000   1.000  1.000  
1100011001 11   Apple, sauce-babyfood              1.000000   1.000  1.000  
1100129000 11   Crabapple                          1.000000   1.000  1.000  
1100173500 11   Goji berry                         1.000000   1.000  1.000  
1100210000 11   Loquat                             1.000000   1.000  1.000  
1100266000 11   Pear                               1.000000   1.000  1.000  
1100266001 11   Pear-babyfood                      1.000000   1.000  1.000  
1100267000 11   Pear, dried                        1.000000   6.250  1.000  
1100268000 11   Pear, juice                        1.000000   1.000  1.000  
1100268001 11   Pear, juice-babyfood               1.000000   1.000  1.000  
1100310000 11   Quince                             1.000000   1.000  1.000  
1201090000 12A  Cherry                             2.500000   1.000  1.000  
1201090001 12A  Cherry-babyfood                    2.500000   1.000  1.000  
1201091000 12A  Cherry, juice                      2.500000   1.500  1.000  
1201091001 12A  Cherry, juice-babyfood             2.500000   1.500  1.000  
1202012000 12B  Apricot                            2.500000   1.000  1.000  
1202012001 12B  Apricot-babyfood                   2.500000   1.000  1.000  
1202013000 12B  Apricot, dried                     2.500000   8.000  1.000  
1202014000 12B  Apricot, juice                     2.500000   1.000  1.000  
1202014001 12B  Apricot, juice-babyfood            2.500000   1.000  1.000  
1202230000 12B  Nectarine                          2.500000   1.000  1.000  
1202260000 12B  Peach                              2.500000   1.000  1.000  
1202260001 12B  Peach-babyfood                     2.500000   1.000  1.000  
1202261000 12B  Peach, dried                       2.500000   8.000  1.000  
1202261001 12B  Peach, dried-babyfood              2.500000   8.000  1.000  
1202262000 12B  Peach, juice                       2.500000   1.000  1.000  
1202262001 12B  Peach, juice-babyfood              2.500000   1.000  1.000  
1203285000 12C  Plum                               2.500000   1.000  1.000  
1203285001 12C  Plum-babyfood                      2.500000   1.000  1.000  
1203286000 12C  Plum, prune, fresh                 2.500000   1.000  1.000  
1203286001 12C  Plum, prune, fresh-babyfood        2.500000   1.000  1.000  
1203287000 12C  Plum, prune, dried                 2.500000   1.000  1.000  
1203287001 12C  Plum, prune, dried-babyfood        2.500000   1.000  1.000  
1203288000 12C  Plum, prune, juice                 2.500000   1.400  1.000  
1203288001 12C  Plum, prune, juice-babyfood        2.500000   1.400  1.000  
1302057000 13B  Blueberry                          2.500000   1.000  1.000  
1302057001 13B  Blueberry-babyfood                 2.500000   1.000  1.000  
1304175000 13D  Grape                              4.000000   1.000  1.000  
1304176000 13D  Grape, juice                       4.000000   0.200  1.000  
1304176001 13D  Grape, juice-babyfood              4.000000   0.200  1.000  
1304179000 13D  Grape, wine and sherry             4.000000   1.000  1.000  
1307359000 13G  Strawberry                         2.500000   1.000  1.000  
1307359001 13G  Strawberry-babyfood                2.500000   1.000  1.000  
1307360000 13G  Strawberry, juice                  2.500000   1.000  1.000  
1307360001 13G  Strawberry, juice-babyfood         2.500000   1.000  1.000  
1400003000 14   Almond                             0.030000   1.000  1.000  
1400003001 14   Almond-babyfood                    0.030000   1.000  1.000  
1400004000 14   Almond, oil                        0.030000   1.000  1.000  
1400004001 14   Almond, oil-babyfood               0.030000   1.000  1.000  
1400059000 14   Brazil nut                         0.030000   1.000  1.000  
1400068000 14   Butternut                          0.030000   1.000  1.000  
1400081000 14   Cashew                             0.030000   1.000  1.000  
1400092000 14   Chestnut                           0.030000   1.000  1.000  
1400155000 14   Hazelnut                           0.030000   1.000  1.000  
1400156000 14   Hazelnut, oil                      0.030000   1.000  1.000  
1400185000 14   Hickory nut                        0.030000   1.000  1.000  
1400213000 14   Macadamia nut                      0.030000   1.000  1.000  
1400269000 14   Pecan                              0.030000   1.000  1.000  
1400282000 14   Pistachio                          0.030000   1.000  1.000  
1400391000 14   Walnut                             0.030000   1.000  1.000  
1500025000 15   Barley, pearled barley             0.100000   1.000  1.000  
1500025001 15   Barley, pearled barley-babyfood    0.100000   1.000  1.000  
1500026000 15   Barley, flour                      0.100000   1.000  1.000  
1500026001 15   Barley, flour-babyfood             0.100000   1.000  1.000  
1500027000 15   Barley, bran                       0.100000   1.000  1.000  
1500127000 15   Corn, sweet                        0.010000   1.000  1.000  
1500127001 15   Corn, sweet-babyfood               0.010000   1.000  1.000  
1500231000 15   Oat, bran                          0.010000   1.000  1.000  
1500232000 15   Oat, flour                         0.010000   1.000  1.000  
1500232001 15   Oat, flour-babyfood                0.010000   1.000  1.000  
1500233000 15   Oat, groats/rolled oats            0.010000   1.000  1.000  
1500233001 15   Oat, groats/rolled oats-babyfood   0.010000   1.000  1.000  
1500328000 15   Rye, grain                         0.010000   1.000  1.000  
1500329000 15   Rye, flour                         0.010000   1.000  1.000  
1500381000 15   Triticale, flour                   0.100000   1.000  1.000  
1500381001 15   Triticale, flour-babyfood          0.100000   1.000  1.000  
1500401000 15   Wheat, grain                       0.100000   1.000  1.000  
1500401001 15   Wheat, grain-babyfood              0.100000   1.000  1.000  
1500402000 15   Wheat, flour                       0.100000   1.000  1.000  
1500402001 15   Wheat, flour-babyfood              0.100000   1.000  1.000  
1500403000 15   Wheat, germ                        0.100000   1.000  1.000  
1500404000 15   Wheat, bran                        0.100000   1.000  1.000  
2001163000 20A  Flax seed, oil                     0.100000   1.000  1.000  
2001319000 20A  Rapeseed, oil                      0.100000   1.000  1.000  
2001319001 20A  Rapeseed, oil-babyfood             0.100000   1.000  1.000  
2001336000 20A  Sesame, seed                       0.100000   1.000  1.000  
2001336001 20A  Sesame, seed-babyfood              0.100000   1.000  1.000  
2001337000 20A  Sesame, oil                        0.100000   1.000  1.000  
2001337001 20A  Sesame, oil-babyfood               0.100000   1.000  1.000  
2003128000 20C  Cottonseed, oil                    0.050000   1.000  1.000  
2003128001 20C  Cottonseed, oil-babyfood           0.050000   1.000  1.000  
3100044000 31   Beef, meat                         0.050000   1.000  1.000  
3100044001 31   Beef, meat-babyfood                0.050000   1.000  1.000  
3100045000 31   Beef, meat, dried                  0.050000   1.920  1.000  
3100046000 31   Beef, meat byproducts              0.100000   1.000  1.000  
3100046001 31   Beef, meat byproducts-babyfood     0.100000   1.000  1.000  
3100047000 31   Beef, fat                          0.100000   1.000  1.000  
3100047001 31   Beef, fat-babyfood                 0.100000   1.000  1.000  
3100048000 31   Beef, kidney                       0.100000   1.000  1.000  
3100049000 31   Beef, liver                        0.400000   1.000  1.000  
3100049001 31   Beef, liver-babyfood               0.400000   1.000  1.000  
3200169000 32   Goat, meat                         0.050000   1.000  1.000  
3200170000 32   Goat, meat byproducts              0.100000   1.000  1.000  
3200171000 32   Goat, fat                          0.100000   1.000  1.000  
3200172000 32   Goat, kidney                       0.100000   1.000  1.000  
3200173000 32   Goat, liver                        0.400000   1.000  1.000  
3300189000 33   Horse, meat                        0.050000   1.000  1.000  
3400290000 34   Pork, meat                         0.050000   1.000  1.000  
3400290001 34   Pork, meat-babyfood                0.050000   1.000  1.000  
3400291000 34   Pork, skin                         0.100000   1.000  1.000  
3400292000 34   Pork, meat byproducts              0.100000   1.000  1.000  
3400292001 34   Pork, meat byproducts-babyfood     0.100000   1.000  1.000  
3400293000 34   Pork, fat                          0.100000   1.000  1.000  
3400293001 34   Pork, fat-babyfood                 0.100000   1.000  1.000  
3400294000 34   Pork, kidney                       0.100000   1.000  1.000  
3400295000 34   Pork, liver                        0.400000   1.000  1.000  
3500339000 35   Sheep, meat                        0.050000   1.000  1.000  
3500339001 35   Sheep, meat-babyfood               0.050000   1.000  1.000  
3500340000 35   Sheep, meat byproducts             0.100000   1.000  1.000  
3500341000 35   Sheep, fat                         0.100000   1.000  1.000  
3500341001 35   Sheep, fat-babyfood                0.100000   1.000  1.000  
3500342000 35   Sheep, kidney                      0.100000   1.000  1.000  
3500343000 35   Sheep, liver                       0.400000   1.000  1.000  
3600222000 36   Milk, fat                          0.015000   1.000  1.000  
3600222001 36   Milk, fat-baby food/infant formu   0.015000   1.000  1.000  
3600223000 36   Milk, nonfat solids                0.015000   1.000  1.000  
3600223001 36   Milk, nonfat solids-baby food/in   0.015000   1.000  1.000  
3600224000 36   Milk, water                        0.015000   1.000  1.000  
3600224001 36   Milk, water-babyfood/infant form   0.015000   1.000  1.000  
3600225001 36   Milk, sugar (lactose)-baby food/   0.015000   1.000  1.000  
7000145000 70   Egg, whole                         0.020000   1.000  1.000  
7000145001 70   Egg, whole-babyfood                0.020000   1.000  1.000  
7000146000 70   Egg, white                         0.020000   1.000  1.000  
7000146001 70   Egg, white (solids)-babyfood       0.020000   1.000  1.000  
7000147000 70   Egg, yolk                          0.020000   1.000  1.000  
7000147001 70   Egg, yolk-babyfood                 0.020000   1.000  1.000  
8601000000 86A  Water, direct, all sources         0.020000   1.000  1.000  
8602000000 86B  Water, indirect, all sources       0.020000   1.000  1.000  
9500023000 O    Banana                             0.200000   1.000  1.000  
9500023001 O    Banana-babyfood                    0.200000   1.000  1.000  
9500024000 O    Banana, dried                      0.200000   3.900  1.000  
9500024001 O    Banana, dried-babyfood             0.200000   3.900  1.000  
9500177000 O    Grape, leaves                      4.000000   1.000  1.000  
9500178000 O    Grape, raisin                      6.000000   1.000  1.000  
9500215000 O    Mango                              0.070000   1.000  1.000  
9500215001 O    Mango-babyfood                     0.070000   1.000  1.000  
9500216000 O    Mango, dried                       0.070000   1.000  1.000  
9500217000 O    Mango, juice                       0.070000   1.000  1.000  
9500217001 O    Mango, juice-babyfood              0.070000   1.000  1.000  
9500245000 O    Papaya                             0.300000   1.000  1.000  
9500245001 O    Papaya-babyfood                    0.300000   1.000  1.000  
9500246000 O    Papaya, dried                      0.300000   1.800  1.000  
9500247000 O    Papaya, juice                      0.300000   1.500  1.000  
9500283000 O    Plantain                           0.200000   1.000  1.000  
9500284000 O    Plantain, dried                    0.200000   3.900  1.000  






Attachment 2:  DEEM-FCID Acute Exposure Estimates
                                       
 
US EPA                                                      Ver. 3.18, 03-08-d
DEEM-FCID ACUTE Analysis for DIFENOCONAZOLE              NHANES 2003-2008 2-Day
Residue file: 128847 Acute Aug 2013.R08               Adjustment factor #2 used.
Analysis Date: 08-13-2014/11:09:38    Residue file dated: 09-25-2013/08:12:04
RAC/FF intake summed over 24 hours
Run Comment: ""
===============================================================================

Summary calculations--per capita:

                   95th Percentile      99th Percentile     99.9th Percentile
                   Exposure   % aRfD    Exposure   % aRfD    Exposure   % aRfD 
                  ---------- --------  ---------- --------  ---------- --------
Total US Population:
                    0.028053    11.22    0.058998    23.60    0.126523    50.61 
All Infants:
                    0.056908    22.76    0.086683    34.67    0.238437    95.37 
Children 1-2:
                    0.071431    28.57    0.113369    45.35    0.276000   110.40 
Children 3-5:
                    0.050407    20.16    0.075530    30.21    0.212138    84.86 
Children 6-12:
                    0.033218    13.29    0.058711    23.48    0.139789    55.92 
Youth 13-19:
                    0.017774     7.11    0.033809    13.52    0.114904    45.96 
Adults 20-49:
                    0.020285     8.11    0.040753    16.30    0.103165    41.27 
Adults 50-99:
                    0.023527     9.41    0.052000    20.80    0.125606    50.24 
Female 13-49:
                    0.020231     8.09    0.040542    16.22    0.103405    41.36 

Attachment 3:  DEEM-FCID Chronic Residue File
                                       
Filename: C:\Documents and Settings\tmorton\My Documents\MyFiles\DEEM Files\128847 Difenoconazole\Petition 2F8134 Oilseeds 20A\128847Chronic Aug 2013 AVG FT WHEAT BARLEY AT TOLERANCE.R08
Chemical: Difenoconazole
RfD(Chronic): .01 mg/kg bw/day  NOEL(Chronic): 0 mg/kg bw/day
RfD(Acute): .25 mg/kg bw/day  NOEL(Acute):  0 mg/kg bw/day
Date created/last modified: 08-22-2013/07:59:00       Program ver. 3.16, 03-08-d
-----------------------------------------------------------------------------------
   EPA     Crop                                   Def Res     Adj.Factors   Comment
   Code     Grp  Commodity Name                    (ppm)       #1    #2   
---------- ---- -------------------------------  ----------  ------ ------  -------
0101052000 1A   Beet, sugar                        0.300000   1.000  1.000  
0101052001 1A   Beet, sugar-babyfood               0.300000   1.000  1.000  
0101053000 1A   Beet, sugar, molasses              0.300000   0.600  1.000  
0101053001 1A   Beet, sugar, molasses-babyfood     0.300000   0.600  1.000  
0101078000 1AB  Carrot                             0.062000   1.000  1.000  
0101078001 1AB  Carrot-babyfood                    0.062000   1.000  1.000  
0101079000 1AB  Carrot, juice                      0.062000   1.000  1.000  
0103015000 1CD  Arrowroot, flour                   1.360000   1.000  1.000  
0103015001 1CD  Arrowroot, flour-babyfood          1.360000   1.000  1.000  
0103017000 1CD  Artichoke, Jerusalem               1.360000   1.000  1.000  
0103082000 1CD  Cassava                            1.360000   1.000  1.000  
0103082001 1CD  Cassava-babyfood                   1.360000   1.000  1.000  
0103139000 1CD  Dasheen, corm                      1.360000   1.000  1.000  
0103166000 1CD  Ginger                             1.360000   1.000  1.000  
0103166001 1CD  Ginger-babyfood                    1.360000   1.000  1.000  
0103167000 1CD  Ginger, dried                      1.360000   1.000  1.000  
0103296000 1C   Potato, chips                      1.360000   0.500  1.000  
0103297000 1C   Potato, dry (granules/ flakes)     1.360000   0.500  1.000  
0103297001 1C   Potato, dry (granules/ flakes)-b   1.360000   0.500  1.000  
0103298000 1C   Potato, flour                      1.360000   0.500  1.000  
0103298001 1C   Potato, flour-babyfood             1.360000   0.500  1.000  
0103299000 1C   Potato, tuber, w/peel              1.360000   1.000  1.000  
0103299001 1C   Potato, tuber, w/peel-babyfood     1.360000   1.000  1.000  
0103300000 1C   Potato, tuber, w/o peel            1.360000   1.000  1.000  
0103300001 1C   Potato, tuber, w/o peel-babyfood   1.360000   1.000  1.000  
0103366000 1CD  Sweet potato                       1.360000   1.000  1.000  
0103366001 1CD  Sweet potato-babyfood              1.360000   1.000  1.000  
0103371000 1CD  Tanier, corm                       1.360000   1.000  1.000  
0103387000 1CD  Turmeric                           1.360000   1.000  1.000  
0103406000 1CD  Yam, true                          1.360000   1.000  1.000  
0103407000 1CD  Yam bean                           1.360000   1.000  1.000  
0301165000 3A   Garlic, bulb                       0.200000   1.000  1.000  
0301165001 3A   Garlic, bulb-babyfood              0.200000   1.000  1.000  
0301237000 3A   Onion, bulb                        0.200000   1.000  1.000  
0301237001 3A   Onion, bulb-babyfood               0.200000   1.000  1.000  
0301238000 3A   Onion, bulb, dried                 0.200000   9.000  1.000  
0301238001 3A   Onion, bulb, dried-babyfood        0.200000   9.000  1.000  
0301338000 3A   Shallot, bulb                      0.200000   1.000  1.000  
0302103000 3B   Chive, fresh leaves                6.000000   1.000  1.000  
0302198000 3B   Leek                               6.000000   1.000  1.000  
0302239000 3B   Onion, green                       6.000000   1.000  1.000  
0302338500 3B   Shallot, fresh leaves              6.000000   1.000  1.000  
0501061000 5A   Broccoli                           0.221000   1.000  1.000  
0501061001 5A   Broccoli-babyfood                  0.221000   1.000  1.000  
0501062000 5A   Broccoli, Chinese                  0.221000   1.000  1.000  
0501064000 5A   Brussels sprouts                   0.029000   1.000  1.000  
0501069000 5A   Cabbage                            0.029000   1.000  1.000  
0501071000 5A   Cabbage, Chinese, napa             0.029000   1.000  1.000  
0501072000 5A   Cabbage, Chinese, mustard          0.221000   1.000  1.000  
0501083000 5A   Cauliflower                        0.221000   1.000  1.000  
0501196000 5A   Kohlrabi                           0.029000   1.000  1.000  
0502063000 5B   Broccoli raab                      5.100000   1.000  1.000  
0502070000 5B   Cabbage, Chinese, bok choy         5.100000   1.000  1.000  
0502117000 5B   Collards                           5.100000   1.000  1.000  
0502194000 5B   Kale                               5.100000   1.000  1.000  
0502229000 5B   Mustard greens                     5.100000   1.000  1.000  
0502318000 5B   Rape greens                        5.100000   1.000  1.000  
0502389000 5B   Turnip, greens                     5.100000   1.000  1.000  
0600347000 6    Soybean, seed                      0.021500   1.000  1.000  
0600349000 6    Soybean, soy milk                  0.021500   1.000  1.000  
0600349001 6    Soybean, soy milk-babyfood or in   0.021500   1.000  1.000  
0600350000 6    Soybean, oil                       0.021500   1.000  1.000  
0600350001 6    Soybean, oil-babyfood              0.021500   1.000  1.000  
0601349500 6AB  Soybean, vegetable                 0.021500   1.000  1.000  
0603098000 6C   Chickpea, seed                     0.017000   1.000  1.000  
0603098001 6C   Chickpea, seed-babyfood            0.017000   1.000  1.000  
0603099000 6C   Chickpea, flour                    0.017000   1.000  1.000  
0603348000 6C   Soybean, flour                     0.021500   1.000  1.000  
0603348001 6C   Soybean, flour-babyfood            0.021500   1.000  1.000  
0801374000 8A   Tomatillo                          0.165000   1.000  1.000  
0801375000 8A   Tomato                             0.165000   1.000  1.000  
0801375001 8A   Tomato-babyfood                    0.165000   1.000  1.000  
0801376000 8A   Tomato, paste                      0.165000   1.600  1.000  
0801376001 8A   Tomato, paste-babyfood             0.165000   1.600  1.000  
0801377000 8A   Tomato, puree                      0.165000   0.500  1.000  
0801377001 8A   Tomato, puree-babyfood             0.165000   0.500  1.000  
0801378000 8A   Tomato, dried                      0.165000  14.300  1.000  
0801378001 8A   Tomato, dried-babyfood             0.165000  14.300  1.000  
0801379000 8A   Tomato, juice                      0.165000   1.500  1.000  
0802148000 8BC  Eggplant                           0.133000   1.000  1.000  
0802234000 8BC  Okra                               0.600000   1.000  1.000  
0802270000 8B   Pepper, bell                       0.133000   1.000  1.000  
0802270001 8B   Pepper, bell-babyfood              0.133000   1.000  1.000  
0802271000 8B   Pepper, bell, dried                0.133000   1.000  1.000  
0802271001 8B   Pepper, bell, dried-babyfood       0.133000   1.000  1.000  
0802272000 8BC  Pepper, nonbell                    0.133000   1.000  1.000  
0802272001 8BC  Pepper, nonbell-babyfood           0.133000   1.000  1.000  
0802273000 8BC  Pepper, nonbell, dried             0.133000   1.000  1.000  
0901075000 9A   Cantaloupe                         0.137000   1.000  1.000  
0901187000 9A   Honeydew melon                     0.137000   1.000  1.000  
0901399000 9A   Watermelon                         0.137000   1.000  1.000  
0901400000 9A   Watermelon, juice                  0.137000   1.000  1.000  
0902021000 9B   Balsam pear                        0.055000   1.000  1.000  
0902088000 9B   Chayote, fruit                     0.310000   1.000  1.000  
0902102000 9B   Chinese waxgourd                   0.055000   1.000  1.000  
0902135000 9B   Cucumber                           0.055000   1.000  1.000  
0902308000 9B   Pumpkin                            0.031000   1.000  1.000  
0902309000 9B   Pumpkin, seed                      0.031000   1.000  1.000  
0902356000 9B   Squash, summer                     0.031000   1.000  1.000  
0902356001 9B   Squash, summer-babyfood            0.031000   1.000  1.000  
0902357000 9B   Squash, winter                     0.031000   1.000  1.000  
0902357001 9B   Squash, winter-babyfood            0.031000   1.000  1.000  
1001106000 10A  Citron                             0.208000   1.000  1.000  
1001107000 10A  Citrus hybrids                     0.208000   1.000  1.000  
1001108000 10A  Citrus, oil                       25.000000   1.000  1.000  
1001240000 10A  Orange                             0.208000   1.000  1.000  
1001241000 10A  Orange, juice                      0.208000   0.100  1.000  
1001241001 10A  Orange, juice-babyfood             0.208000   0.100  1.000  
1001242000 10A  Orange, peel                       0.208000   1.000  1.000  
1001369000 10A  Tangerine                          0.208000   1.000  1.000  
1001370000 10A  Tangerine, juice                   0.208000   0.100  1.000  
1002197000 10B  Kumquat                            0.208000   1.000  1.000  
1002199000 10B  Lemon                              0.176000   1.000  1.000  
1002200000 10B  Lemon, juice                       0.176000   0.100  1.000  
1002200001 10B  Lemon, juice-babyfood              0.176000   0.100  1.000  
1002201000 10B  Lemon, peel                        0.176000   1.000  1.000  
1002206000 10B  Lime                               0.176000   1.000  1.000  
1002207000 10B  Lime, juice                        0.176000   0.100  1.000  
1002207001 10B  Lime, juice-babyfood               0.176000   0.100  1.000  
1003180000 10C  Grapefruit                         0.120000   1.000  1.000  
1003181000 10C  Grapefruit, juice                  0.120000   0.100  1.000  
1003307000 10C  Pummelo                            0.120000   1.000  1.000  
1100007000 11   Apple, fruit with peel             0.203000   1.000  1.000  
1100008000 11   Apple, peeled fruit                0.203000   1.000  1.000  
1100008001 11   Apple, peeled fruit-babyfood       0.203000   1.000  1.000  
1100009000 11   Apple, dried                       0.203000   8.000  1.000  
1100009001 11   Apple, dried-babyfood              0.203000   8.000  1.000  
1100010000 11   Apple, juice                       0.203000   0.040  1.000  
1100010001 11   Apple, juice-babyfood              0.203000   0.040  1.000  
1100011000 11   Apple, sauce                       0.203000   1.000  1.000  
1100011001 11   Apple, sauce-babyfood              0.203000   1.000  1.000  
1100129000 11   Crabapple                          0.203000   1.000  1.000  
1100173500 11   Goji berry                         0.123000   1.000  1.000  
1100210000 11   Loquat                             0.123000   1.000  1.000  
1100266000 11   Pear                               0.123000   1.000  1.000  
1100266001 11   Pear-babyfood                      0.123000   1.000  1.000  
1100267000 11   Pear, dried                        0.123000   6.250  1.000  
1100268000 11   Pear, juice                        0.123000   1.000  1.000  
1100268001 11   Pear, juice-babyfood               0.123000   1.000  1.000  
1100310000 11   Quince                             0.123000   1.000  1.000  
1201090000 12A  Cherry                             0.622000   1.000  1.000  
1201090001 12A  Cherry-babyfood                    0.622000   1.000  1.000  
1201091000 12A  Cherry, juice                      0.622000   1.500  1.000  
1201091001 12A  Cherry, juice-babyfood             0.622000   1.500  1.000  
1202012000 12B  Apricot                            0.421000   1.000  1.000  
1202012001 12B  Apricot-babyfood                   0.421000   1.000  1.000  
1202013000 12B  Apricot, dried                     0.421000   8.000  1.000  
1202014000 12B  Apricot, juice                     0.421000   1.000  1.000  
1202014001 12B  Apricot, juice-babyfood            0.421000   1.000  1.000  
1202230000 12B  Nectarine                          0.421000   1.000  1.000  
1202260000 12B  Peach                              0.421000   1.000  1.000  
1202260001 12B  Peach-babyfood                     0.421000   1.000  1.000  
1202261000 12B  Peach, dried                       0.421000   8.000  1.000  
1202261001 12B  Peach, dried-babyfood              0.421000   8.000  1.000  
1202262000 12B  Peach, juice                       0.421000   1.000  1.000  
1202262001 12B  Peach, juice-babyfood              0.421000   1.000  1.000  
1203285000 12C  Plum                               0.295000   1.000  1.000  
1203285001 12C  Plum-babyfood                      0.295000   1.000  1.000  
1203286000 12C  Plum, prune, fresh                 0.295000   1.000  1.000  
1203286001 12C  Plum, prune, fresh-babyfood        0.295000   1.000  1.000  
1203287000 12C  Plum, prune, dried                 0.295000   2.600  1.000  
1203287001 12C  Plum, prune, dried-babyfood        0.295000   2.600  1.000  
1203288000 12C  Plum, prune, juice                 0.295000   1.400  1.000  
1203288001 12C  Plum, prune, juice-babyfood        0.295000   1.400  1.000  
1302057000 13B  Blueberry                          0.495000   1.000  1.000  
1302057001 13B  Blueberry-babyfood                 0.495000   1.000  1.000  
1304175000 13D  Grape                              0.613000   1.000  1.000  
1304176000 13D  Grape, juice                       0.613000   0.200  1.000  
1304176001 13D  Grape, juice-babyfood              0.613000   0.200  1.000  
1304179000 13D  Grape, wine and sherry             0.613000   1.000  1.000  
1307359000 13G  Strawberry                         0.495000   1.000  1.000  
1307359001 13G  Strawberry-babyfood                0.495000   1.000  1.000  
1307360000 13G  Strawberry, juice                  0.495000   1.000  1.000  
1307360001 13G  Strawberry, juice-babyfood         0.495000   1.000  1.000  
1400003000 14   Almond                             0.005000   1.000  1.000  
1400003001 14   Almond-babyfood                    0.005000   1.000  1.000  
1400004000 14   Almond, oil                        0.005000   1.000  1.000  
1400004001 14   Almond, oil-babyfood               0.005000   1.000  1.000  
1400059000 14   Brazil nut                         0.007000   1.000  1.000  
1400068000 14   Butternut                          0.007000   1.000  1.000  
1400081000 14   Cashew                             0.007000   1.000  1.000  
1400092000 14   Chestnut                           0.005000   1.000  1.000  
1400155000 14   Hazelnut                           0.007000   1.000  1.000  
1400156000 14   Hazelnut, oil                      0.007000   1.000  1.000  
1400185000 14   Hickory nut                        0.007000   1.000  1.000  
1400213000 14   Macadamia nut                      0.007000   1.000  1.000  
1400269000 14   Pecan                              0.007000   1.000  1.000  
1400282000 14   Pistachio                          0.005000   1.000  1.000  
1400391000 14   Walnut                             0.007000   1.000  1.000  
1500025000 15   Barley, pearled barley             0.100000   1.000  1.000  
1500025001 15   Barley, pearled barley-babyfood    0.100000   1.000  1.000  
1500026000 15   Barley, flour                      0.100000   1.000  1.000  
1500026001 15   Barley, flour-babyfood             0.100000   1.000  1.000  
1500027000 15   Barley, bran                       0.100000   1.000  1.000  
1500127000 15   Corn, sweet                        0.010000   1.000  1.000  
1500127001 15   Corn, sweet-babyfood               0.010000   1.000  1.000  
1500231000 15   Oat, bran                          0.010000   1.000  1.000  
1500232000 15   Oat, flour                         0.010000   1.000  1.000  
1500232001 15   Oat, flour-babyfood                0.010000   1.000  1.000  
1500233000 15   Oat, groats/rolled oats            0.010000   1.000  1.000  
1500233001 15   Oat, groats/rolled oats-babyfood   0.010000   1.000  1.000  
1500328000 15   Rye, grain                         0.010000   1.000  1.000  
1500329000 15   Rye, flour                         0.010000   1.000  1.000  
1500381000 15   Triticale, flour                   0.100000   1.000  1.000  
1500381001 15   Triticale, flour-babyfood          0.100000   1.000  1.000  
1500401000 15   Wheat, grain                       0.100000   1.000  1.000  
1500401001 15   Wheat, grain-babyfood              0.100000   1.000  1.000  
1500402000 15   Wheat, flour                       0.100000   1.000  1.000  
1500402001 15   Wheat, flour-babyfood              0.100000   1.000  1.000  
1500403000 15   Wheat, germ                        0.100000   1.000  1.000  
1500404000 15   Wheat, bran                        0.100000   1.000  1.000  
2001163000 20A  Flax seed, oil                     0.100000   1.000  1.000  
2001319000 20A  Rapeseed, oil                      0.100000   1.000  1.000  
2001319001 20A  Rapeseed, oil-babyfood             0.100000   1.000  1.000  
2001336000 20A  Sesame, seed                       0.100000   1.000  1.000  
2001336001 20A  Sesame, seed-babyfood              0.100000   1.000  1.000  
2001337000 20A  Sesame, oil                        0.100000   1.000  1.000  
2001337001 20A  Sesame, oil-babyfood               0.100000   1.000  1.000  
2003128000 20C  Cottonseed, oil                    0.050000   1.000  1.000  
2003128001 20C  Cottonseed, oil-babyfood           0.050000   1.000  1.000  
3100044000 31   Beef, meat                         0.050000   1.000  1.000  
3100044001 31   Beef, meat-babyfood                0.050000   1.000  1.000  
3100045000 31   Beef, meat, dried                  0.050000   1.920  1.000  
3100046000 31   Beef, meat byproducts              0.100000   1.000  1.000  
3100046001 31   Beef, meat byproducts-babyfood     0.100000   1.000  1.000  
3100047000 31   Beef, fat                          0.100000   1.000  1.000  
3100047001 31   Beef, fat-babyfood                 0.100000   1.000  1.000  
3100048000 31   Beef, kidney                       0.100000   1.000  1.000  
3100049000 31   Beef, liver                        0.400000   1.000  1.000  
3100049001 31   Beef, liver-babyfood               0.400000   1.000  1.000  
3200169000 32   Goat, meat                         0.050000   1.000  1.000  
3200170000 32   Goat, meat byproducts              0.100000   1.000  1.000  
3200171000 32   Goat, fat                          0.100000   1.000  1.000  
3200172000 32   Goat, kidney                       0.100000   1.000  1.000  
3200173000 32   Goat, liver                        0.400000   1.000  1.000  
3300189000 33   Horse, meat                        0.050000   1.000  1.000  
3400290000 34   Pork, meat                         0.050000   1.000  1.000  
3400290001 34   Pork, meat-babyfood                0.050000   1.000  1.000  
3400291000 34   Pork, skin                         0.100000   1.000  1.000  
3400292000 34   Pork, meat byproducts              0.100000   1.000  1.000  
3400292001 34   Pork, meat byproducts-babyfood     0.100000   1.000  1.000  
3400293000 34   Pork, fat                          0.100000   1.000  1.000  
3400293001 34   Pork, fat-babyfood                 0.100000   1.000  1.000  
3400294000 34   Pork, kidney                       0.100000   1.000  1.000  
3400295000 34   Pork, liver                        0.400000   1.000  1.000  
3500339000 35   Sheep, meat                        0.050000   1.000  1.000  
3500339001 35   Sheep, meat-babyfood               0.050000   1.000  1.000  
3500340000 35   Sheep, meat byproducts             0.100000   1.000  1.000  
3500341000 35   Sheep, fat                         0.100000   1.000  1.000  
3500341001 35   Sheep, fat-babyfood                0.100000   1.000  1.000  
3500342000 35   Sheep, kidney                      0.100000   1.000  1.000  
3500343000 35   Sheep, liver                       0.400000   1.000  1.000  
3600222000 36   Milk, fat                          0.015000   1.000  1.000  
3600222001 36   Milk, fat-baby food/infant formu   0.015000   1.000  1.000  
3600223000 36   Milk, nonfat solids                0.015000   1.000  1.000  
3600223001 36   Milk, nonfat solids-baby food/in   0.015000   1.000  1.000  
3600224000 36   Milk, water                        0.015000   1.000  1.000  
3600224001 36   Milk, water-babyfood/infant form   0.015000   1.000  1.000  
3600225001 36   Milk, sugar (lactose)-baby food/   0.015000   1.000  1.000  
7000145000 70   Egg, whole                         0.020000   1.000  1.000  
7000145001 70   Egg, whole-babyfood                0.020000   1.000  1.000  
7000146000 70   Egg, white                         0.020000   1.000  1.000  
7000146001 70   Egg, white (solids)-babyfood       0.020000   1.000  1.000  
7000147000 70   Egg, yolk                          0.020000   1.000  1.000  
7000147001 70   Egg, yolk-babyfood                 0.020000   1.000  1.000  
8601000000 86A  Water, direct, all sources         0.013600   1.000  1.000  
8602000000 86B  Water, indirect, all sources       0.013600   1.000  1.000  
9500023000 O    Banana                             0.200000   1.000  1.000  
9500023001 O    Banana-babyfood                    0.200000   1.000  1.000  
9500024000 O    Banana, dried                      0.200000   3.900  1.000  
9500024001 O    Banana, dried-babyfood             0.200000   3.900  1.000  
9500177000 O    Grape, leaves                      0.613000   1.000  1.000  
9500178000 O    Grape, raisin                      0.613000   3.500  1.000  
9500215000 O    Mango                              0.070000   1.000  1.000  
9500215001 O    Mango-babyfood                     0.070000   1.000  1.000  
9500216000 O    Mango, dried                       0.070000   1.000  1.000  
9500217000 O    Mango, juice                       0.070000   1.000  1.000  
9500217001 O    Mango, juice-babyfood              0.070000   1.000  1.000  
9500245000 O    Papaya                             0.300000   1.000  1.000  
9500245001 O    Papaya-babyfood                    0.300000   1.000  1.000  
9500246000 O    Papaya, dried                      0.300000   1.800  1.000  
9500247000 O    Papaya, juice                      0.300000   1.500  1.000  
9500283000 O    Plantain                           0.200000   1.000  1.000  
9500284000 O    Plantain, dried                    0.200000   3.900  1.000  


Attachment 4:  DEEM-FCID Chronic Exposure Estimates



US EPA                                                          Ver. 3.16, 03-08-d
DEEM-FCID Chronic analysis for DIFENOCONAZOLE              NHANES 2003-2008 2-day
Residue file name: C:\Users\tmorton\Documents\My Files\DEEM Files\128847 Difenoconazole\Petition 2F8134 Oilseeds 20A and Dragonfruit\128847Chronic Aug 2013 AVG FT WHEAT BARLEY AT TOLERANCE.R08
                                                     Adjustment factor #2 used.
Analysis Date 08-13-2014/11:10:27     Residue file dated: 09-25-2013/08:11:21
Reference dose (RfD, Chronic) = .01 mg/kg bw/day
===============================================================================
                    Total exposure by population subgroup
-------------------------------------------------------------------------------

                                                    Total Exposure
                                         -----------------------------------
          Population                         mg/kg             Percent of   
           Subgroup                       body wt/day             Rfd       
--------------------------------------   -------------       ----------------
Total US Population                         0.002685                26.9%
Hispanic                                    0.002695                26.9%
Non-Hisp-White                              0.002650                26.5%
Non-Hisp-Black                              0.002711                27.1%
Non-Hisp-Other                              0.003075                30.8%
Nursing Infants                             0.002931                29.3%
Non-Nursing Infants                         0.005629                56.3%
Female 13+ PREG                             0.002420                24.2%
Children 1-6                                0.006387                63.9%
Children 7-12                               0.003360                33.6%
Male 13-19                                  0.002154                21.5%
Female 13-19/NP                             0.001991                19.9%
Male 20+                                    0.002238                22.4%
Female 20+/NP                               0.002213                22.1%
Seniors 55+                                 0.002359                23.6%
All Infants                                 0.004796                48.0%
Female 13-50                                0.002090                20.9%
Children 1-2                                0.007816                78.2%
Children 3-5                                0.005781                57.8%
Children 6-12                               0.003616                36.2%
Youth 13-19                                 0.002069                20.7%
Adults 20-49                                0.002144                21.4%
Adults 50-99                                0.002348                23.5%
Female 13-49                                0.002092                20.9%

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