Prometon Focus Meeting Summary

November 7, 2012 

1:00 – 2:00 pm

Attendees

MANA:  Kristen Knox and (via conference line) Elliot Gordon

Control Solutions, Inc.(via conference line): Anne Turnbough

Environmental Protection Agency (EPA or Agency): Kaitlin Keller (PRD),
Tracy Perry (PRD), William Irwin (HED), Robin Sternberg (EFED), Steve
Wente (EFED), Sujatha Sankula (EFED), Cynthia Doucoure (BEAD), John
Faulkner (BEAD)

Objective

The purpose of the meeting was for members of the EPA’s Pesticide
Re-evaluation Division (PRD),  Environmental Fate and Effects Division
(EFED), Biological and Economic Analysis Division (BEAD), and Health
Effects Division (HED)  to meet with Mahkteshim Agan of North America
(MANA), the technical registrant for prometon, for the following
reasons: 1) discuss usage information needed for the registration review
ecological risk assessments, and 2) discuss anticipated ecotoxicity and
environmental fate data requirements and information that could be
submitted to fulfill these data gaps. 

Discussion

Use/Usage Information

CSI provided usage information in terms of amounts used in pounds per
year, noting that this information can be broken down by product and
will be submitted to the Agency via email with a complete summary of
labels and use sites.  MANA confirmed that all residential use products
have been cancelled, as required by the Reregistration Eligibility
Decision (RED). EPA has already received a FIFRA 6(f) request to cancel
all residential uses of prometon on October 3, 2012, which will be
published with a 30-day comment period in the Federal Register in FY
2013 Q1.  EPA requested additional information on typical rates for each
use scenario and the size of a typical spot treatment along various use
sites, such as highway medians, fencerows, and airports.  EPA noted that
this information could help reduce conservatisms in the ecological risk
assessments.  

Environmental Fate and Effects Information

EPA requested additional information on the degradates of prometon,
specifically how long they take to break down and any toxicity effects
in the environment and/or any laboratory studies using rats.  MANA
committed to reviewing their database and providing any information
within three weeks of the meeting date.

EPA also presented a list of anticipated data gaps and explained that
some conservative methods, such as the acute-to-chronic ratio, could be
used to account for the lack of several of the data gaps.   MANA stated
that European Union (EU) data is not available for this chemical and all
studies were already submitted before the RED was completed.  EPA
suggested reviewing open literature and their database for information
on other triazine herbicides, such as atrazine and simazine, for
information which may be useful.  EPA agreed to review and consider any
proposals or waiver requests based on a rationale of low toxicity and/or
bridging data used for other triazine class herbicides.  EPA requested
any water monitoring data available.  MANA was not aware of this
information but agreed to submit any water monitoring data that they may
find.

Follow-up

EPA will inform MANA when the 6(f) voluntary cancellation request for
all prometon residential uses publishes in the Federal Register.

MANA and CSI will submit use/usage and market share information, as well
as typical use rates and size of typical spot treatments.

MANA will review their scientific database and open literature sources
for information that could fulfill current data gaps and respond to EPA
with this information within three weeks. 

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