EPA REGISTRATION DIVISION COMPANY NOTICE OF FILING FOR PESTICIDE PETITIONS PUBLISHED IN THE FEDERAL REGISTER  

EPA Registration Division contact: [P.V. Shah, 703-308-1846]


INSTRUCTIONS:  Please utilize this outline in preparing the pesticide petition.  In cases where the outline element does not apply, please insert "NA-Remove" and maintain the outline. Please do not change the margins, font, or format in your pesticide petition. Simply replace the instructions that appear in green, i.e., "[insert company name]," with the information specific to your action

[Joint Inerts Task Force, Cluster Support Team 2 (JITF CST2)]

[2E8092]

	EPA has received a pesticide petition (2E8092) from [Joint Inerts Task Force, Cluster Support Team 2, EPA Company Number 84914], [c/o Huntsman Corp., 8600 Gosling Rd., The Woodlands, TX  77381] proposing, pursuant to section 408(d) of the Federal Food, Drug, and Cosmetic Act (FFDCA), 21 U.S.C. 346a(d), to amend 40 CFR part 180.

To amend existing exemptions from the requirement of a tolerance [by adding Chemical Abstracts Service Registry Numbers (CASRNs) for post-harvest use on agricultural crops under 40 CFR §180.910 and when applied to animals under 40 CFR §180.930 for the following two chemistry descriptors that are used as surfactants not to exceed 30% of pesticide formulation: Alkyl Alcohol Alkoxylate Phosphate and Sulfate Derivatives (AAAPD and AAASD respectively), including:

AAAPD Surfactants:

40 CFR §180.910 and §180.930: α-Alkyl (minimum C6 linear or branched, saturated and or unsaturated)-ω-hydroxypolyoxyethylene polymer with or without polyoxypropylene, mixture of di- and monohydrogen phosphate esters and the corresponding ammonium, calcium, magnesium, monoethanolamine, potassium, sodium, and zinc salts of the phosphate esters; minimum oxyethylene content averages 2 moles; minimum oxypropylene content is 0 moles; used as surfactants not to exceed 30% of pesticide formulation.

                                     CASRN
                              AAAPD Chemical Name
                                  103170-31-6
Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C8-10-alkyl ethers, phosphates, potassium salts
                                  103170-32-7
Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, monococo alkyl ethers, phosphates, potassium salts
                                  106233-09-4
                   Alcohols, C16-18, ethoxylated, phosphates
                                  106233-10-7
Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C12-20-alkyl ethers, phosphates
                                 1072943-56-6
Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C11-14-isoalkyl ethers, C13-rich, phosphates, sodium salts
                                  110392-49-9
            Alcohols, C9-11, ethoxylated, phosphated, sodium salt 
                                  111798-26-6
   Poly(oxy-1,2-ethanediyl), a-(2-ethylhexyl)-w-hydroxy-, phosphate, Na salt
                                  111905-50-1
           Alcohols C16-18, ethoxylated, phosphated, potassium salt
                                  116671-23-9
Poly(oxy-1,2-ethanediyl), a,a'-phosphinicobis[w-hydroxy-, di-C12-14-alkyl ethers, sodium salts
                                  117584-36-8
Poly(oxy-1,2-ethanediyl), a,a'-phosphinicobis[w-hydroxy-, di-C12-15-alkyl ethers
                                 1187742-89-7
    Alcohols C16-18 and C18 unsatured, ethoxylated (2 EO), phosphate salt 
                                 1187743-35-6
   Alcohols, C16-18 and C18-unsatd., ethoxylated, phosphate, potassium salt
                                  119415-05-3
Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C16-20-alkyl ethers, phosphates, sodium salts
                                  121158-61-0
Poly(oxy-1,2-ethanediyl), a,a'-phosphinicobis[w-hydroxy-, di-C12-14-alkyl ethers
                                  121158-63-2
    Poly(oxy-1,2-ethanediyl), a-phosphono-w-hydroxy-, C12-14-alkyl ethers 
                                  125139-13-1
     Poly(oxy-1,2-ethanediyl), a-phosphono-w-hydroxy-, C14-18-alkyl ethers
                                  125301-86-2
     Poly(oxy-1,2-ethanediyl), a-phosphono-w-hydroxy-, C6-10-alkyl ethers
                                  125301-87-3
Poly(oxy-1,2-ethanediyl), a-phosphono-w-hydroxy-, C10-14-alkyl ethers, potassium salts
                                  126646-03-5
Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C10-14-alkyl ethers, phosphates, potassium salts 
                                  129870-77-5
Oxirane, methyl-, polymer with oxirane, mono(C13-15-branched and linear alkyl) ethers, phosphates
                                  129870-80-0
Poly(oxy-1,2-ethanediyl), a-phosphono-w-hydroxy-, C10-14-alkyl ethers, disodium salts
                                  130354-37-9
Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C12-13-alkyl ethers, phosphates, sodium salts 
                                  136504-88-6
Poly(oxy-1,2-ethanediyl), .alpha.-hydro-.omega.-hydroxy-, mono-C9-11-alkyl ethers, phosphates
                                  143372-50-3
Poly(oxy-1,2-ethanediyl), a,a'-phosphinicobis[w-hydroxy-, di-C13-15-alkyl ethers, ammonium salts
                                  143372-51-4
Poly(oxy-1,2-ethanediyl), a-phosphono-w-hydroxy-, C13-15-alkyl ethers, diammonium salts
                                  154518-40-8
Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono(C10-rich C9-11-isoalkyl) ethers, phosphates, potassium salts
                                  155240-11-2
Poly(oxy-1,2-ethanediyl), .alpha.-hydro-.omega.-hydroxy-, mono-C12-18-alkyl ethers, phosphates
                                  160498-49-7
Poly(oxy-1,2-ethanediyl), .alpha.-hydro-.omega.-hydroxy-, mono-C13-15-alkyl ethers, phosphates, ammonium salts
                                  160611-24-5
Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, monotallow alkyl ethers, phosphates, sodium salts 
                                  171543-66-1
    Poly(oxy-1,2-ethanediyl), a,a'-phosphinicobis[w-(hexyloxy)-, NH4 salt 
                                  210493-60-0
Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mixed mono-C16-20-isoalkyl & monotallow alkyl ethers, phosphates, Na salts 
                                  246159-55-7
Poly(oxy-1,2-ethanediyl), .alpha.-hydro-.omega.-hydroxy-, mono-C12-16-alkyl ethers, phosphates
                                  251298-11-0
Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C16-18-alkyl ethers, phosphates, sodium salts 
                                  261627-68-3
Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C11-14-isoalkyl ethers, C13-rich, phosphates, potassium salts
                                  26982-05-8
         Poly(oxy-1,2-ethanediyl), a,a'-phosphinicobis[w-(dodecyloxy)-
                                  31800-89-2
          Poly(oxy-1,2-ethanediyl), a,a'-phosphinicobis[w-(octyloxy)-
                                  39341-09-8
          Poly(oxy-1,2-ethanediyl), a,a'-phosphinicobis[w-(decyloxy)-
                                  39341-65-6
     Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, 2-ethylhexyl phosphate 
                                  39464-69-2
   Poly(oxy-1,2-ethanediyl), a-(9Z)-9-octadecen-1-yl-w-hydroxy-, phosphate 
                                  422563-19-7
Poly(oxy-1,2-ethanediyl), a-(2-ethylhexyl)-w-hydroxy-, phosphate, ammonium salt
                                  50668-50-3
Poly(oxy-1,2-ethanediyl), a,a'-phosphinicobis[w-(dodecyloxy)-, potassium salt (1:1)
                                  51884-64-1
          Poly(oxy-1,2-ethanediyl), a,a'-phosphinicobis[w-(hexyloxy)-
                                  57486-09-6
Poly(oxy-1,2-ethanediyl), a-9-octadecenyl-w-hydroxy-, (Z)-, phosphate, sodium salt 
                                  59112-71-9
Poly(oxy-1,2-ethanediyl), a-(9Z)-9-octadecen-1-yl-w-hydroxy-, phosphate, potassium salt
                                  62362-49-6
         Poly(oxy-1,2-ethanediyl), a-octadecyl-w-hydroxy-, phosphate 
                                  63747-86-4
    Oxirane, 2-methyl-, polymer with oxirane, monododecyl ether, phosphate 
                                  63887-55-8
Poly(oxy-1,2-ethanediyl), a,a'-phosphinicobis[w-(decyloxy)-, potassium salt (1:1)
                                  66272-25-1
         Poly(oxy-1,2-ethanediyl), a-isododecyl-w-hydroxy-, phosphate
                                  67786-06-5
Poly(oxy-1,2-ethanediyl), a-phosphono-w-[(2-ethylhexyl)oxy]-, potassium salt (1:2)
                                  67989-06-4
           Poly(oxy-1,2-ethanediyl), a-hexyl-w-hydroxy-, phosphate 
                                  68071-37-4
Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C12-15-alkyl ethers, phosphates, potassium salts
                                  68130-44-9
Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C12-13-alkyl ethers, phosphates, potassium salts
                                  68130-45-0
Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C12-13-alkyl ethers, phosphates
                                  68130-46-1
Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C12-13-alkyl ethers, phosphates, magnesium salts 
                                  68186-29-8
    Poly(oxy-1,2-ethanediyl), a-tridecyl-w-hydroxy-, phosphate, sodium salt
                                  68186-34-5
Poly(oxy-1,2-ethanediyl), a-[(9Z)-1-oxo-9-octadecen-1-yl]-w-hydroxy-, phosphate, sodium salt 
                                  68238-84-6
Poly(oxy-1,2-ethanediyl), a-(2-ethylhexyl)-w-hydroxy-, phosphate, potassium salt
                                  68311-04-6
 Poly(oxy-1,2-ethanediyl), a-phosphono-w-(tridecyloxy)-, potassium salt (1:2)
                                  68389-72-0
      Poly(oxy-1,2-ethanediyl), a-(sec-pentadecyl)-w-hydroxy-, phosphate 
                                  68413-78-5
  Poly(oxy-1,2-ethanediyl), a,a'-phosphinicobis[w-[(1-methyltetradecyl)oxy]-
                                  68425-75-2
Ethanol, 2-amino-, polymer with a-tridecyl-w-hydroxypoly(oxy-1,2-ethanediyl) phosphate
                                  68439-39-4
       Poly(oxy-1,2-ethanediyl), a-(2-ethylhexyl)-w-hydroxy-, phosphate
                                  68511-15-9
Oxirane, 2-methyl-, polymer with oxirane, monodecyl ether, phosphate, sodium salt 
                                  68511-36-4
Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C11-15-alkyl ethers, phosphates
                                  68551-05-3
Oxirane, 2-methyl-, polymer with oxirane, mono-C10-12-alkyl ethers, phosphates
                                  68585-15-9
 Oxirane, 2-methyl-, polymer with oxirane, mono-C6-10-alkyl ethers, phosphates
                                  68585-16-0
Oxirane, 2-methyl-, polymer with oxirane, mono-C6-10-alkyl ethers, phosphates, potassium salts 
                                  68585-17-1
Oxirane, 2-methyl-, polymer with oxirane, mono-C6-10-alkyl ethers, phosphates, sodium salts
                                  68585-39-7
Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C8-10-alkyl ethers, phosphates, sodium salts
                                  68603-24-7
Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, monococo alkyl ethers, phosphates, ammonium salts 
                                  68607-14-7
Polyphosphoric acids, esters with polyethylene glycol mono-C11-15-sec-alkyl ethers 
                                  68610-64-0
Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C16-22-alkyl ethers, phosphates, sodium salts
                                  68649-30-9
Oxirane, 2-methyl-, polymer with oxirane, mono-C12-18-alkyl ethers, phosphates 
                                  68650-84-0
Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C11-15-alkyl ethers, phosphates, potassium salts 
                                  68855-46-9
Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C11-15-sec-alkyl ethers, phosphates, sodium salts
                                  68856-03-1
Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C10-15-sec-alkyl ethers, phosphates 
                                  68890-90-4
Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C11-15-branched alkyl ethers, phosphates, potassium salts 
                                  68890-91-5
Oxirane, 2-methyl-, polymer with oxirane, mono-C10-12-alkyl ethers, phosphates, potassium salts
                                  68891-12-3
Oxirane, 2-methyl-, polymer with oxirane, mono-C10-16-alkyl ethers, phosphates, sodium salts 
                                  68891-26-9
   Poly(oxy-1,2-ethanediyl), a,a'-phosphinicobis[w-(tridecyloxy)-, branched 
                                  68909-65-9
Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C10-16-alkyl ethers, phosphates
                                  68909-67-1
Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono(C8-18 and C18-unsatd. alkyl) ethers, phosphates
                                  68909-69-3
Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C11-13-branched alkyl ethers, phosphates
                                  68921-24-4
Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C6-12-alkyl ethers, phosphate
                                  68921-60-8
Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C11-15-sec-alkyl ethers, phosphates 
                                  68954-87-0
Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C10-16-alkyl ethers, phosphates, potassium salts
                                  68954-88-1
Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C12-20-alkyl ethers, phosphates, sodium salts
                                  68954-92-7
Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C11-13-branched alkyl ethers, phosphates, potassium salts
                                  68987-35-9
          Poly(oxy-1,2-ethanediyl), a-eicosyl-w-hydroxy-, phosphate 
                                  69029-43-2
   Poly(oxy-1,2-ethanediyl), a-tridecyl-w-hydroxy-, phosphate, ammonium salt
                                  69980-69-4
   Poly(oxy-1,2-ethanediyl), a-octadecyl-w-hydroxy-, phosphate, sodium salt 
                                  70247-99-3
Poly(oxy-1,2-ethanediyl), .alpha.-hydro-.omega.-hydroxy-, mono-C4-18-alkyl ethers, phosphates, potassium salts
                                  70248-14-5
Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C6-10-alkyl ethers, phosphates 
                                  70903-63-8
   Poly(oxy-1,2-ethanediyl), a-hexadecyl-w-hydroxy-, phosphate, sodium salt
                                  71965-23-6
Oxirane, 2-methyl-, polymer with oxirane, mono(dihydrogen phosphate), tridecyl ether
                                  71965-24-7
Oxirane, 2-methyl-, polymer with oxirane, mono(dihydrogen phosphate), tridecyl ether, dipotassium salt
                                  72480-27-4
Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C9-16-alkyl ethers, phosphates
                                  72623-67-7
Oxirane, 2-methyl-, polymer with oxirane, mono(dihydrogen phosphate), 2-ethylhexyl ether
                                  72623-68-8
Oxirane, 2-methyl-, polymer with oxirane, hydrogen phosphate (2:1), bis(2-ethylhexyl) ether
                                  72828-56-9
Poly(oxy-1,2-ethanediyl), a,a'-phosphinicobis[w-hydroxy-, di-C12-14-alkyl ethers, potassium salts
                                  72828-57-0
Poly(oxy-1,2-ethanediyl), a-phosphono-w-hydroxy-, C12-14-alkyl ethers, dipotassium salts
                                  73018-34-5
    Poly(oxy-1,2-ethanediyl), a-octyl-w-hydroxy-, phosphate, potassium salt
                                  73050-08-5
Poly(oxy-1,2-ethanediyl), a,a'-phosphinicobis[w-hydroxy-, di-C13-15-alkyl ethers, sodium salts
                                  73050-09-6
Poly(oxy-1,2-ethanediyl), a-phosphono-w-hydroxy-, C13-15-alkyl ethers, disodium salts 
                                  73361-29-2
    Oxirane, methyl-, polymer with oxirane, monohexadecyl ether, phosphate 
                                  73378-71-9
Poly(oxy-1,2-ethanediyl), a,a'-phosphinicobis[w-hydroxy-, di-C9-11-alkyl ethers, sodium salts
                                  73378-72-0
Poly(oxy-1,2-ethanediyl), a-phosphono-w-hydroxy-, C9-11-alkyl ethers, disodium salts
                                  73559-42-9
Poly(oxy-1,2-ethanediyl), a,a'-phosphinicobis[w-hydroxy-, di-C10-20-alkyl ethers
                                  73559-43-0
Poly(oxy-1,2-ethanediyl), a,a'-phosphinicobis[w-hydroxy-, di-C10-20-alkyl ethers, potassium salts
                                  73559-44-1
Poly(oxy-1,2-ethanediyl), a-phosphono-w-hydroxy-, C10-20-alkyl ethers, dipotassium salts 
                                  73559-45-2
     Poly(oxy-1,2-ethanediyl), a-phosphono-w-hydroxy-, C10-20-alkyl ethers
                                  74499-76-6
Poly(oxy-1,2-ethanediyl), a,a'-phosphinicobis[w-(tridecyloxy)-, potassium salt (1:1)
                                  76930-25-1
  Phosphoric acid, mono- and di-C12-18 alkyl ester, sodium salt, ethoxylated
                                  78330-22-0
Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C11-14-isoalkyl ethers, C13-rich, phosphates, ethoxylated
                                   9004-80-2
             Poly(oxy-1,2-ethanediyl), a-phosphono-w-(decyloxy)- 
                                  91254-26-1
Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono(C16 and C18-unsatd. alkyl) ethers, phosphates 
                                  93925-54-3
Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, monococo alkyl ethers, phosphates, sodium salts 
                                  96416-89-6
Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-, mono-C11-15-sec-alkyl ethers, phosphates, potassium salts 


AAASD Surfactants:

40CFR 180.910 and 180.930:  α-Alkyl(C6-C15)-ω-hydroxypoly(oxyethylene) sulfate, and its ammonium, calcium, magnesium, potassium, sodium, and zinc salts, poly(oxyethylene) content averages 2-4 moles; used as surfactants not to exceed 30% of pesticide formulation.

                                     CASRN
                              AAASD Chemical Name
                                  106597-03-9
Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C13-15-branched alkyl ethers, sodium salts
                                  110392-50-2
Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C12-13-alkyl ethers, sodium salts
                                  125301-88-4
Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C12-14-alkyl ethers, ammonium salts
                                  125301-89-5
Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C12-15-alkyl ethers, ammonium salts
                                  125301-92-0
Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C12-15-alkyl ethers, sodium salts
                                  125736-54-1
Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C12-14-sec-alkyl ethers, sodium salts
                                  157707-85-2
Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C6-12-alkyl ethers, sodium salts
                                  160104-51-8
Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C12-14-alkyl ethers, magnesium salts
                                  160901-27-9
Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C9-11-branched and linear alkyl ethers, ammonium salts
                                  160901-28-0
Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C9-11-branched and linear alkyl ethers, sodium salts
                                  160901-29-1
Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C11-14-branched and linear alkyl ethers, sodium salts
                                  160901-30-4
Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C9-15-alkyl ethers, sodium salts
                                  161025-28-1
             Alcohols, C6-12, ethoxylated, sulfates, sodium salts
                                  161074-79-9
  Alcohols, C12-13, branched and linear, ethoxylated, sulfates, sodium salts 
                                  162063-19-6
Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C13-15-branched and linear alkyl ethers, sodium salts
                                  27140-00-7
   Ethanol, 2-[2-(dodecyloxy)ethoxy]-, 1-(hydrogen sulfate), ammonium salt 
                                  27731-61-9
  Poly(oxy-1,2-ethanediyl), a-sulfo-w-(tetradecyloxy)-, ammonium salt (1:1) 
                                  27731-62-0
    Poly(oxy-1,2-ethanediyl), a-sulfo-w-(tetradecyloxy)- sodium salt (1:1) 
                                  34431-25-9
      Poly(oxy-1,2-ethanediyl), a-sulfo-w-(octyloxy)-, sodium salt (1:1)
                                  35015-74-8
   Poly(oxy-1,2-ethanediyl), a-sulfo-w-(pentadecyloxy)-, sodium salt (1:1) 
                                  52286-18-7
     Poly(oxy-1,2-ethanediyl), a-sulfo-w-(octyloxy)-, ammonium salt (1:1) 
                                  52286-19-8
        Poly(oxy-1,2-ethanediyl), a-sulfo-w-(decyloxy)-, ammonium salt
                                  54116-08-4
        Poly(oxy-1,2-ethanediyl), a-sulfo-w-(tridecyloxy)-, sodium salt
                                  61702-79-2
    Poly(oxy-1,2-ethanediyl), a-sulfo-w-(tridecyloxy)-, ammonium salt (1:1)
                                  63428-86-4
     Poly(oxy-1,2-ethanediyl), a-sulfo-w-(hexyloxy)-, ammonium salt (1:1)
                                  63428-87-5
      Poly(oxy-1,2-ethanediyl), a-sulfo-w-(decyloxy)-, sodium salt (1:1)
                                  65086-57-9
                Poly(oxy-1,2-ethanediyl), a-sulfo-w-(decyloxy)-
                                  65086-79-5
             Poly(oxy-1,2-ethanediyl), a-sulfo-w-(tetradecyloxy)-
                                  67674-66-2
             Poly(oxy-1,2-ethanediyl), a-sulfo-w-(pentadecyloxy)-
                                  67845-82-3
                Poly(oxy-1,2-ethanediyl), a-sulfo-w-(octyloxy)-
                                  67845-83-4
     Poly(oxy-1,2-ethanediyl), a-sulfo-w-(pentadecyloxy)-, ammonium salt 
                                  68037-05-8
Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C6-10-alkyl ethers, ammonium salts
                                  68037-06-9
       Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C6-10-alkyl ethers
                                  68171-41-5
                Poly(oxy-1,2-ethanediyl), a-sulfo-w-(hexyloxy)-
                                  68610-66-2
Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C10-12-alkyl ethers, sodium salts
                                  68649-53-6
Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C12-13-alkyl ethers, ammonium salts
                                  68890-88-0
Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C10-12-alkyl ethers, ammonium salts
                                  68891-29-2
Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C8-10-alkyl ethers, ammonium salts
                                  68891-30-5
Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C11-15-branched alkyl ethers, ammonium salts
                                  69011-37-6
Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C8-14-alkyl ethers, ammonium salts
                                  75422-21-8
Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C6-12-alkyl ethers, ammonium salts
                                  78330-17-3
    Poly(oxy-1,2-ethanediyl), a-sulfo-w-(hexyloxy)-, branched, sodium salt
                                  78330-16-2
   Poly(oxy-1,2-ethanediyl), a-sulfo-w-(hexyloxy)-, branched, ammonium salt
                                  78330-25-3
Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C7-9-isoalkyl ethers, C8-rich, ammonium salts
                                  78330-26-4
Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C9-11-isoalkyl ethers, C10-rich, ammonium salts
                                  78330-27-5
Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C11-14-isoalkyl ethers, C13-rich, ammonium salts
                                  78330-28-6
Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C7-9-isoalkyl ethers, C8-rich, sodium salts
                                  78330-29-7
Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C9-11-isoalkyl ethers, C10-rich, sodium salts
                                  78330-30-0
Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C11-14-isoalkyl ethers, C13-rich, sodium salts
                                   9021-91-4
  Poly[oxy(methyl-1,2-ethanediyl)], a-sulfo-w-(octyloxy)-, sodium salt (1:1) 
                                  96130-61-9
Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C9-11-alkyl ethers, sodium salts

in or on all raw agricultural commodities.  [Prior to the submission of this petition to add missing CASRNs, Petition PP 9E7533 (Document ID EPA-HQ-OPP-2009-0131) was submitted to the Agency and these CASRNs were missing from the petition.  JITF CST2 is relying on the information submitted in 9E7533 to support this petition which includes the exact same chemistries.  JITF CST2 does not expect the addition of these CASRNs to result in additional exposure or risk.]  EPA has determined that the petition contains data or information regarding the elements set forth in section 408 (d)(2) of  FFDCA; however, EPA has not fully evaluated the sufficiency of the submitted data at this time or whether the data supports granting of the petition. Additional data may be needed before EPA rules on the petition.

A. Residue Chemistry

      1. Plant metabolism.	[Not Applicable]

	2. Analytical method. [Not Applicable]

	3. Magnitude of residues. [There is no specific crop residue information available for AAAPD and AAASD and this information is typically not available nor required for the establishment of a tolerance exemption for inert ingredients.] 

B. Toxicological Profile

1. Acute toxicity.  [AAAPD and AAASD are likely skin/eye irritants in their undiluted forms, but not acutely toxic. The reported oral LD50 values were higher than 1,600 mg/kg for the alkyl ether phosphates C13EO3,6,12P, CASRN 9046-01-9 and alkyl ether sulfates NaC12EO3S, CASRN 9004-82-4 (Category III).  No effects were found at any of the concentrations tested dermally.]

	2. Genotoxicity. [NaC12-15EO2-3S compounds were not mutagenic in bacterial or mammalian in vitro cell systems or in vivo (HERA 2003).  Neither IARC, NTP nor OSHA listed as a carcinogen.]

	3. Reproductive and developmental toxicity. [One representative compound for the group of chemicals requested in 9E7533  (and 2E8092) is CASRN 68891-38-3 Poly(oxy-1,2-ethanediyl), a-sulfo-w-hydroxy-, C12-14-alkyl ethers, sodium salts.  The studies with the sulfate derivatives (AAASD) showed little to no toxicity in the dams or the pups, with the NOEL in a developmental toxicity study in rats with CASRN 68891-38-3 at the limit dose of 1000 mg/kg/day, and a reproductive NOAEL of 0.3% in drinking water, equivalent to 300 mg/kg/day, the highest dose tested, in a two-generation reproduction study with CASRN 68891-38-3).  

CASRN 68891-38-3 was evaluated for effects on the reproduction and prenatal/postnatal development of the rat when administered orally via the drinking water through two successive generations.  No reproductive or developmental effects were observed at any dose, even where corresponding parental toxicity was observed.  The NOAEL for reproductive effects was 0.3% in drinking water, equivalent to 300 mg/kg/day, the highest dose tested. 

In studies with the phosphate derivatives (AAAPD), the reproductive/developmental NOEL for the OECD 422 study with CASRN 68130-47-2 was 800 mg/kg/day, the highest dose tested, and for CASRN 78330-24-2 the NOEL was 200 mg/kg/day.
	
	4. Subchronic toxicity. [Based on the Federal Register Notice (August 9, 2006, Volume 71, Number 153, pages 45415-45424), the Agency stated that the preferred test for repeat-dose toxicity is the "Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test (OECD Test Guideline 422)."
AAAPD (CASRN  68130-47-2 and CASRN 78330-24-2) have been tested in repeat dose studies (OECD 422 Combined Repeated Dose Toxicity Study with a Reproduction/Developmental Toxicity Screening Test).  The paternal and maternal NOAEL for CASRN 68130-47-2 was 200 mg/kg/day.  The paternal and maternal no-observable-effect-level (NOEL) for CASRN 78330-24-2 was 200 mg/kg/day.  The NOAEL of 200 mg/kg/day was selected as the toxicology endpoint for the chronic risk assessment for the phosphate derivatives (AAAPD).

Subchronic data have been found in the public domain for the AAASD.   Subchronic 21-day repeat dose dietary studies showed low toxicity of compounds with carbon lengths of C12-15, C12-14 and C13-15 with sodium or ammonium alkyl ethoxylates with POE n=3.  One study indicated that C16-18 POE n=18 had comparable low toxicity.  No-observed-adverse-effect levels (NOAELs) range from 120 to 468 mg/kg/day, similar to a NOAEL from a 90-day rat gavage study with NaC12-14 POE n=2(CASRN 68891-38-3), which was reported to be 225 mg/kg/day.  In addition, another 90-day repeat dose dietary study with NaC12-15 POE n=3(CASRN 68424-50-0) resulted in low toxicity, with a NOAEL of greater than approximately 50 mg/kg/day (calculated based on dose of 1000 ppm in diet).  Effects were usually related to hepatic hypertrophy, increased liver weight, and related increases in hematological endpoints related to liver enzyme induction.

Henkel KgaA (1994a) evaluated CASRN 68891-38-3 for systemic toxicity in Wistar (Hsd/Win:WU) rats by gavage at doses of 0, 25, 75, and 225 mg/kg/day for 90-days.  No treatment related symptoms including changes in mean food consumption or water intake, total body weight gain, hematological examinations, clinical chemistry, absolute and relative organ weights and macroscopical examinations were observed in any group.   According to systemic, behavioral, and clinical abnormalities the NOAEL of 225 mg/kg/day for sodium lauryl ether sulfate was determined.

CASRN 68891-38-3 was evaluated for effects on the reproduction and prenatal/postnatal development of the rat when administered orally via the drinking water through two successive generations. Based on this study an overall no-observed-adverse-effect level (NOAEL) for systemic effects was 0.1%, which was 86.6 mg/kg/day for the F0 generation, and 149.5 mg/kg/day for the F1 generation. The NOAEL of 86.6 mg/kg/day was selected as the toxicology endpoint for the chronic risk assessment for the sulfate derivatives (AAASD).]

	5. Chronic toxicity [Based on the Federal Register Notice (August 9, 2006, Volume 71, Number 153, pages 45415-45424), the Agency stated that the preferred test for repeat-dose toxicity is the "Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test (OECD Test Guideline 422)." 

Chronic dietary studies conducted with rats on AAASDs showed no incidence of cancer and no effects at the concentrations tested (lowest dose tested was ca 75 mg/kg/day).]  

	6. Animal metabolism. [The mammalian metabolic pathway for AAASD type surfactants has been published.  The mammalian metabolic pathway for AAASD type surfactants has been published (HERA, 2003). For compounds of comparable C16 carbon chain, the metabolites of the lower molecular weight ethoxylated (POE n=3) AAASD surfactants are readily absorbed and excreted primarily in the urine whereas for the C16 AAASD surfactants with increased ethoxylation (POE n=9) are poorly absorbed and excreted primarily in the feces (McDermott et al., 1975).   There was also no evidence of hydrolysis of the sulfate group from C16 POE n= 3 and C16 POE n=9 or of metabolism of the ethoxylate portion of the molecule.  With C11 POE n=3 and C12 POE n=3 metabolic studies in rats confirmed that the alkyl chain is extensively metabolized by beta- or omega-oxidation leaving the ethoxysulfate, which is excreted directly (Taylor et al., (1978)

By analogy to what would generally be expected in the metabolism for phosphate esters, the AAAPD surfactants may initially undergo metabolism to generate the corresponding AAA and POE (or POE/POP) phosphate glycol.  By analogy to the reported metabolism for the CST1 Alkyl Alkoxylate Alcohol (AAA) surfactants, the dephosphoralyted metabolite should be hydrolyzed to the POE (or POE/POP) polyalkoxylate glycols and linear branched saturated and unsaturated alkyl alcohol metabolites.  The resultant alkyl alcohol metabolites would be oxidized in fatty acid oxidation pathways.  The polyalkoxylate glycols may either be conjugated and excreted unchanged or hydrolyzed/oxidized to various degraded metabolites before being conjugated and excreted.] 
 
	7. Metabolite toxicology. [No metabolites of toxicological concern are expected based on the proposed animal metabolic pathway.]

	8. Endocrine disruption. [The AAAPD and AAASD surfactants do not belong to a class of chemicals known or suspected of having adverse effects on the estrogen receptor or endocrine system.  AAAPD and AAASD have been evaluated in acute, subchronic, developmental and reproductive studies capable of detecting effects on endocrine mediated events. The results of these studies did not give any indication of a treatment-related effect on the estrogen receptor or endocrine system.]

C. Aggregate Exposure

       1. Dietary exposure. [The dietary (food plus drinking water) exposures for AAAPD and AAASD surfactants are expressed as a percentage of the proposed chronic population adjusted dose (cPAD) for the general US population and children 1-2 years old, the subpopulation with the highest potential exposures.  
 
 Based on I-DEEM screening level calculations, the chronic dietary exposures for the AAAPD are estimated to be 6% of the cPAD for the general U.S. population and 21% of the cPAD for children 1-2 years old.  
 
 Based on I-DEEM screening level calculations, the chronic dietary exposures for the AAASD are estimated to be 14% of the cPAD for the general U.S. population and 49% of the cPAD for children 1-2 years old.  
 
 These data demonstrate that the I-DEEM screening level chronic dietary (food and drinking water) exposures for both the AAAPD and AAASD are well below 100% of the cPAD, and are therefore below EPA's established level of concern for all U.S. subpopulations.

On the basis of the OECD 422 repeat dose toxicity study and comparison of I-DEEM exposures to the proposed cPAD, the JITF CST2 asserts that there is sufficient basis for EPA to grant a tolerance exemption for these additional AAAPD and AAASD surfactant CASRNs. 

CHRONIC DIETARY SAFETY ASSESSMENT, % cPAD

                                     Study
                           Chronic Systemic NOAEL 1
                                 mg/kg bw/day
                                    cPAD[2]
                                 mg/kg bw/day 
                                Percent  cPAD 
                           Children 1-2 years of age
                                 Percent cPAD 
                              U.S. Gen Population
AAAPD CASRN 68130-47-2  and CASRN 78330-24-2; Repeated Dose Toxicity with Reproduction/
Developmental Toxicity Screening in Rats- (OECD 422) 

AAASD Sulfate CASRN 68891-38-3;  systemic toxicity endpoint for repeated dose from the two generation rat reproductive drinking water study

200




87
                                      2.0
                                       
                                       
                                       
                                       
                                     0.87
                                      21%
                                       
                                       
                                       
                                       
                                      49%
                                      6%
                                       
                                       
                                       
                                       
                                      14%
 Note:
 [1] NOAEL  -  No observed adverse effect level
 [2] cPAD  -  Chronic population adjusted dose, defined as:  chronic NOAEL / (safety factor  FQPA factor)

 i. Food. [The available data demonstrate that the I-DEEM screening level chronic dietary (food and drinking water) exposures are well below 100% of the cPAD, and are therefore below EPA's established level of concern for all U.S. subpopulations.]
 
	ii. Drinking water. [Drinking water is included in the I-DEEM exposure assessment. Exposure to AAAPD and AAASD via drinking water is expected to be negligible.]

	2. Non-dietary exposure. [AAAPD and AAASD surfactants are used as inert ingredients in agricultural formulations as well as in non-pesticidal uses such as, personal care products household cleaning products and laundry detergents. Given the low estimate of dietary exposure, there is ample room in the overall aggregate MOE for non-dietary uses.]

D. Cumulative Effects

	[For the purpose of the tolerance exemption actions cited herein, the JITF CST2 has assumed that the AAAPD and AAASD will not have a common mechanism of toxicity with other surfactant substances. It is therefore appropriate to consider only the potential risks of the compounds included in CST2 in the exposure assessment.]

E. Safety Determination

      1. U.S. population. [A dietary exposure assessment using current EPA inert screening level methodology (I-DEEM) was conducted. Based on the conservative I-DEEM dietary exposure estimates, there is a reasonable certainty that no harm will result to the US population from the aggregate exposure to AAAPD and AAASD.]

      2. Infants and children. [The FFDCA Section 408 requires an additional tenfold margin of safety for the protection of infants and children in case of threshold effects to account for prenatal and postnatal toxicity, and an inadequate toxicity database.  Where an adequate and reliable database is available and there is a lack of evidence for increased susceptibility, the FQPA safety factor may be reduced or removed.  An evaluation of susceptibility and uncertainty issues associated with Anionic Alkyl Alkoxylate Derivatives has been performed.  Based on the points below, the JITF CST2 recommends that the FQPA safety factor be reduced from the default 10X to 1X. 

* A scientifically sound mammalian toxicology database, which includes acute, subchronic, reproductive, and developmental toxicity data, indicates no adverse effects to sensitive populations.
* The AAAPD and AAASD surfactants do not belong to a class of chemicals known or suspected of having adverse effects on the estrogen receptor or endocrine system.  These surfactants have been evaluated in acute, subchronic, developmental and reproductive studies capable of detecting effects on endocrine mediated events. 
* The AAASDs have also been evaluated in chronic studies including a two year dietary study (Moore 1983) and a two generation reproduction study with drinking water (Henkel KGaA 1999, MRID 470609903, 47112401).
* OECD 422 testing and other reproduction and developmental studies available in the literature (HERA, 2003) indicates no reproductive and no developmental effects in offspring at levels that are not maternally toxic. 
* There was no evidence of effects on the nervous system in the acute, subchronic or reproduction studies.] 

F. International Tolerances

	[There are no known international tolerances for Alkyl Alcohol Alkoxylate Phosphate and Sulfate Derivatives.]

