
                 UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
                            WASHINGTON, D.C.  20460
                                       
	OFFICE OF	CHEMICAL SAFETY AND	POLLUTION PREVENTION



Date:		08-MAY-2013

            Subject:	Fenpyroximate.  Petition for the Establishment of Permanent Tolerances for Residues in/on Stone Fruits (Group 12-12), Tuberous and Corm Vegetables (Subgroup 1C), and Small Vine Climbing Fruits Except Kiwifruit (Subgroup 13-07F).  Acute and Chronic Dietary Exposure and Risk Assessments.

PC Code:  129131
DP Barcode:  D405718
Decision No.:  468635
Registration Nos:  71711-19, 71711-4
Petition No.:  2E8072
Regulatory Action:  Sec. 3 Registration
Risk Assessment Type:  Dietary 
Case No.:  7432
TXR No.:  NA
CAS No.:  134098-61-6 (E-isomer)
MRID No.:  None
40 CFR:  §180.566

From:		George F. Kramer, Ph.D., Senior Chemist
		Risk Assessment Branch 1 (RAB1)
		Health Effects Division (HED; 7509P)

Through:		Julie L. Van Alstine, MPH, Environmental Health Scientist
		Thurston Morton, Chemist
            Dietary Exposure Science Advisory Council (DESAC)/HED (7509P)
                  and
		Dana M. Vogel, Acting Branch Chief, RAB1
		Associate Division Director, HED (7509P)

         To:		Jennifer R. Tyler, Risk Assessor
		RAB1/HED (7509P)
            and
      Barbara Madden/Sidney Jackson, RM 05
      Registration Division (RD; 7505P)
      

Executive Summary

Acute and chronic aggregate dietary (food + drinking water) exposure and risk assessments were conducted for fenpyroximate using the Dietary Exposure Evaluation Model - Food Consumption Intake Database (DEEM-FCID, ver. 3.16) which incorporates consumption data from United States Department of Agriculture (USDA) National Health and Nutrition Examination Survey, What We Eat in America, (NHANES/WWEIA; 2003-2008).  The analyses were performed to support Section 3 use requests on stone fruits (group 12-12), small vine climbing fruits except kiwifruit (subgroup 13-07F), and tuberous and corm vegetables (subgroup 1C).
Acute Dietary (Food + Drinking Water) Exposure Results and Characterization

Separate acute dietary risk analyses were conducted for females 13-49 years old and for the general U.S. population, as separate endpoints of concern attributable to a single dose were identified.  Both acute analyses assumed 100% crop treated (CT), tolerance-level residues for all commodities.  DEEM (ver. 7.81) default processing factors were assumed for all commodities excluding apple, pear, and grape juice (0.11x); grape, raisin (2.7x); orange, grapefruit, tangerine, lemon, and lime juice (0.06x); tomato paste (1.0x) and puree (1.0x); dried plum (1.0x); and peppermint and spearmint oil (0.08x).  The acute analyses incorporated the estimated drinking water concentrations (EDWCs) provided by Environmental Fate and Effects Division (EFED).  An EDWC of 0.043 ppm was used in the acute analyses, as this was the highest (i.e., most conservative) estimate.  

The resulting acute food plus drinking water risk estimates are not of concern to HED (<100% acute population-adjusted dose (aPAD)) at the 95[th] percentile of the exposure.  The resulting acute risk estimate is 13% of the aPAD at the 95[th] percentile of the exposure distribution for females 13 to 49 years old.  The highest acute exposure estimate for the U.S. population or population subgroup is children 1-2 years old, which resulted in a risk estimate of 6.2% aPAD.

Chronic Dietary (Food + Drinking Water) Exposure Results and Characterization

The chronic analysis assumed DEEM (ver. 7.81) default processing factors, 100% CT, tolerance-level residues for all commodities, and DEEM (ver. 7.81) default processing factors for most commodities (see above).  The chronic analysis also incorporated EDWCs provided by EFED (an EDWC of 0.0086 ppm was used in the chronic analysis).  The resulting chronic risk estimates are not of concern to HED.  The most highly exposed population was children 1-2 years old utilizing 15% of the chronic PAD (cPAD).

A chronic cancer dietary assessment was not conducted since it was determined that fenpyroximate is not a possible human carcinogen. 


I.  Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide.  For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health effects).  This dose is referred to as the PAD.  The PAD is equivalent to point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty and/or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD.  References which discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site:  "Available Information on Assessing Exposure from Pesticides, A User's Guide," 21-JUN-2000, web link:  http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf; or see SOP 99.6 (20-AUG-1999).

The most recent dietary risk assessment for fenpyroximate was conducted by S. Levy (23-MAY-2012; DP# 391844).
II.  Residue Information

Fenpyroximate is a contact insecticide/miticide used for the control of leafhoppers, mealybugs, and mites.  Fenpyroximate is a mitochondrial electron-transport inhibitor (METI) which acts by targeting proton-translocating NADH:Q oxidoreductase and blocking ubiquinone reduction.

Residues of Concern:  Acceptable plant metabolism studies with fenpyroximate on apples, citrus, cotton, and grapes were previously submitted.  HED has determined (Memo, J. Stokes, 12-AUG-2003; D292639) that the residues of concern for plants for the purposes of tolerance enforcement and risk assessment are fenpyroximate 4-[[[(E)-[(1,3-dimethyl-5-phenoxy-1H-pyrazol-4-yl)
methylene]amino]oxy] methyl]benzoate plus its Z-isomer (also called metabolite M-1 or 4-[[[(Z)-[(1,3-dimethyl-5-phenoxy-1H-pyrazol-4-yl) methylene]amino]oxy]methyl]benzoate).  

 The nature of residue in lactating goats is understood.  The HED Metabolism Assessment Review Committee (MARC) concluded that for milk and the fat, meat, and meat byproducts (excluding liver and kidney) of cattle, goat, horse, and sheep, the parent compound, and its metabolites (E)-4-[(1,3-dimethyl-5-phenoxypyrazol-4-yl)-methylene aminooxymethyl]benzoic acid and (E)-1,1-dimethylethyl-2-hydroxyethyl 4-[[[[(1,3-dimethyl-5-phenoxy-1H-pyrazol-4-yl) methylene] amino]oxy]methyl]benzoate, calculated as the parent compound, are the residues of concern (Memo, J. Stokes, 12-AUG-2003; D292639).  Additionally, the residues of concern for cattle, goat, horse, and sheep liver and kidney are fenpyroximate and its metabolite (E)-4-[(1,3-dimethyl-5-phenoxypyrazol-4-yl)-methylene aminooxymethyl]benzoic acid, calculated as the parent compound.
 
 For drinking water, the residues of concern for risk assessment include the parent, M-1 and M-3.

Established/Recommended Tolerances:  Fenpyroximate tolerances are established in 40 CFR §180.566.  Tolerances for residues in/on plant commodities are expressed in terms of the combined residues of fenpyroximate and its Z-isomer.  Permanent tolerances for residues in/on plant commodities, under §180.566(a)(1), range from 0.10 ppm to 20 ppm.  Tolerances for residues in/on milk and the fat, meat, and meat byproducts (excluding liver and kidney) of cattle, goat, horse, and sheep are listed in 40 CFR §180.566(a)(2) and are expressed in terms of the combined residues of fenpyroximate and its metabolites (E)-4-[(1,3-dimethyl-5-phenoxypyrazol-4-yl)-methylene aminooxymethyl]benzoic acid and (E)-1,1-dimethylethyl-2-hydroxyethyl 4-[[[[(1,3-dimethyl-5-phenoxy-1H-pyrazol-4-yl)methylene]amino]oxy]methyl]benzoate, calculated as the parent compound.  Tolerances for residues in cattle, goat, horse, and sheep liver and kidney are listed under 40 CFR §180.566(a)(3) at 0.25 ppm and are expressed in terms fenpyroximate and its metabolite (E)-4-[(1,3-dimethyl-5-phenoxypyrazol-4-yl)-methylene aminooxymethyl]benzoic acid, calculated as the parent compound.  A time-limited tolerance for residues in/on honey at 0.10 ppm with a 12/31/13 expiration date is listed in 40 CFR §180.566(b) under a Section 18 Emergency Exemption.  

The Interregional Project No. 4 (IR-4) has proposed a Section 3 Registration for application of fenpyroximate to stone fruits (group 12-12), small vine climbing fruits except kiwifruit (subgroup 13-07F), and tuberous and corm vegetables (subgroup 1C).  IR-4, requests the establishment of tolerances for the combined residues of the insecticide fenpyroximate in/on the following raw agricultural commodities (RACs).  

                                   Commodity
                        HED-Recommended Tolerance (ppm)
Fruit, stone, group 12-12
                                      2.0
Vegetable, tuberous and corm, subgroup lC
                                     0.10
Fruit, small, vine climbing, except fuzzy kiwifruit, subgroup 13-07F
                                      1.0

No new residue data were submitted to support tolerance on small vine climbing fruits except kiwifruit (subgroup 13-07F).  IR-4 has requested that the established tolerance for residues in/on grape be expanded to its respective crop group.

 Residues used in the Acute and Chronic Analysis:  These analyses employed established and HED-recommended tolerance-level residues for all commodities and DEEM (ver. 7.81) default processing factors for all commodities excluding apple, pear, and grape juice (0.11x); grape, raisin (2.7x); orange, grapefruit, tangerine, lemon, and lime juice (0.06x); tomato paste (1.0x) and puree (1.0x); dried plum (1.0x); and peppermint and spearmint oil (0.08x).
 
 
 III.  EDWCs

Drinking water residues were incorporated directly into the acute and chronic dietary analyses ("water, direct, all sources" and "water, indirect, all sources") and were provided by EFED (Memo, G. Orrick, 20-SEP-2012; D404840).  The EDWCs were screening-level estimates generated with the Food Quality Protection Act (FQPA) Index Reservoir Screening Tool (FIRST) and a Provisional Cranberry Model for fenpyroximate and its metabolites (M-1 and M-3) in surface water and with Screening Concentration in Ground Water (SCI-GROW) for ground water.  Although the current and proposed end-use labels that result in the highest exposure are for ornamentals (an application rate to ornamentals of 0.343 lbs ai/A with a maximum application of 0.686 lbs ai/A), the use scenario with the highest acute and chronic EDWCs are for the cranberry scenario (see Table 1).

Table 1.  Maximum Screening EDWCs of Fenpyroximate for Current and Proposed Uses.[1]
                         Drinking Water Source (model)
                           Use (Maximum Annual Rate)
           Upper-Bound Estimated Drinking Water Concentrations (ppb)


                             Acute (peak exposure)
                        Chronic (annual mean exposure)
Surface Water (FIRST)
Ornamentals (0.69 lb ai/A)
                                      29
                                      1.9
Surface Water (Cranberry model)
Cranberries (0.20 lb ai/A)
                                      43
                                      8.6
Groundwater (SCI-GROW)
Ornamentals (0.69 lb ai/A)
                                   <0.27
  [1]  Maximum values in bold.

Surface water EDWCs of 0.043 ppm and 0.0086 ppm were used in the acute and chronic analyses, respectively, as these values were the highest and provided a more conservative approach.


IV.  DEEM-FCID Program and Consumption Information

Fenpyroximate acute and chronic dietary exposure assessments were conducted using DEEM-FCID (ver. 3.16) which incorporates consumption data from USDA's NHANES/WWEIA.  This dietary survey was conducted from 2003 to 2008.  The data are based on the reported consumption of more than 20,000 individuals over two non-consecutive survey days.  Foods "as consumed" (e.g., apple pie) are linked to EPA-defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA.  For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups.  Based on analysis of the 2003-2008 WWEIA consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50-99 years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or food-form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food form to produce a residue intake estimate.  The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure.  Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD.  This procedure is performed for each population subgroup.

For acute exposure assessments, individual one-day food consumption data are used on an individual-by-individual basis.  The reported consumption amounts of each food item can be multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or "matched" in multiple random pairings with residue values and then summed in a probabilistic assessment.  The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating relevant commodities/food forms) and a per-capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis.  In accordance with HED policy, per capita exposure and risk are reported for all tiers of analysis.  However, for Tiers 1 and 2, any significant differences in user vs. per capita exposure and risk are specifically identified and noted in the risk assessment.
 
 
 V.  Toxicological Information
 
 The toxicological endpoints as presented in the previous risk assessment are summarized below in Table 2.

Table 2.  Summary of Toxicological Dose and Endpoints for Fenpyroximate for Use in Dietary Risk Assessment[1].
Exposure
Scenario
Point of Departure
Uncertainty/FQPA Safety Factors
Study and Toxicological Effects
Acute Dietary
(Females 13-49 years old)
                                  NOAEL = 5.0
                                   mg/kg bw
UF = 100X
(for inter- and intra-species extrapolation)

FQPA SF = 1X
aRfD = aPAD = 0.05 mg/kg bw
Prenatal Developmental Toxicity Study - Rat
LOAEL = 25 mg/kg/day based on increase in the fetal incidence of additional thoracic ribs.
Acute Dietary
(General population)
                             NOAEL = 37.5 mg/kg bw
UF = 100X
(for inter- and intra-species extrapolation)

FQPA SF = 1X
aRfD = aPAD = 0.375 mg/kg bw
Acute Neurotoxicity Study  -  Rat
LOAEL = 150 mg/kg bw based on decreased motor activity (total activity counts and total time spent in movement) in both sexes, and a reduction in auditory startle response in females at 24 hours post dose, and mild dehydration in males.
Chronic Dietary
(All populations)
                                  NOAEL = 5.0
                                   mg/kg/day
                                       
UF = 100X
(for inter- and intra-species extrapolation)

FQPA SF = 1X
cRfD = cPAD
 = 0.05 mg/kg/day
Chronic toxicity - Dog
LOAEL = 15 mg/kg/day based on an increased incidence of bradycardia, diarrhea, and decreases in cholesterol, body-weight gain, and food consumption (M); vomiting, diarrhea, excess salivation and decrease cholesterol in females.
Cancer 
(Oral, dermal, inhalation)
Classification:  "Not likely to be carcinogen," cancer risk assessment is not required.
[1]  NOAEL = no-observed adverse-effect level, LOAEL = lowest-observed adverse-effect level, RfD = reference dose, PAD = population-adjusted dose (a = acute, c = chronic), MOE = margin of exposure, UF = uncertainty factor, SF = safety factor.


 VI.  Results/Discussion
 
 Acute and chronic analyses were performed using DEEM-FCID (ver. 3.16).  DEEM-FCID (ver. 3.16) estimates the dietary exposure of the U.S. population and various population subgroups.  The results reported are for the general U.S. population, all infants (<1 year old), children 1-2 years old, children 3-5 years old, children 6-12 years old, youth 13-19 years old, females 13-49 years old, adults 20-49 years old, and adults 50-99 years old.  
 
The resulting acute food plus drinking water risk estimates are not of concern to HED (<100% aPAD) at the 95[th] percentile of the exposure.  The resulting acute risk estimate is 13% of the aPAD at the 95[th] percentile of the exposure distribution for females 13 to 49 years old.  The highest acute exposure estimate for the U.S. population or population subgroup is children 1-2 years old, which resulted in a risk estimate of 6.2% aPAD.

The resulting chronic exposure estimates are not of concern to HED.  The most highly exposed population was children 1-2 years old utilizing 15% of the cPAD (see Table 3 for a summary of the results).  A chronic cancer dietary assessment was not conducted since it was determined that fenpyroximate is not a possible human carcinogen. 

 Table 3.  Summary of Dietary (Food + Drinking Water) Exposure and Risk for Fenpyroximate.
                             Population Subgroup[1]
                                Acute Dietary[2]
                                (95 Percentile)
                               Chronic Dietary[3]
                                     Cancer
                                        
                                    Dietary
                              Exposure (mg/kg/day)
                                     % aPAD
                                Dietary Exposure
                                  (mg/kg/day)
                                     % cPAD
                                Dietary Exposure
                                  (mg/kg/day)
                                      Risk
General U.S. Population
                                    0.008312
                                      2.2
                                   0.002208
                                      4.4
                                       NA
                                       NA
All Infants (<1 year old)
                                    0.022585
                                      6.0
                                   0.004700
                                      9.4
                                        
                                        
 Children 1-2 years old
                                    0.023191
                                      6.2
                                    0.007336
                                       15
                                        
                                        
 Children 3-5 years old
                                    0.016596
                                      4.4
                                    0.005098
                                       10
                                        
                                        
 Children 6-12 years old
                                    0.009835
                                      2.6
                                    0.002723
                                      5.4
                                        
                                        
 Youth 13-19 years old
                                    0.005336
                                      1.4
                                    0.001394
                                      2.8
                                        
                                        
 Adults 20-49 years old
                                    0.006565
                                      1.8
                                    0.001712
                                      3.4
                                        
                                        
 Adults 50-99 years old
                                    0.006917
                                      1.8
                                    0.002013
                                      4.0
                                        
                                        
 Females 13-49 years old
                                    0.006685
                                       13
                                    0.001693
                                      3.4
                                        
                                        
 [1]  The values for the highest exposed population for each type of risk assessment is bolded.
 [2]  Separate acute toxicity endpoints were determined for females 13-49 years old and the general U.S. population and all population subgroups (see Table 2). 
 [3]  Chronic dietary endpoint of 0.05 mg/kg/day applies to the general U.S. population and all population subgroups.  


 VII.  Characterization of Inputs/Outputs
 
The acute and chronic analyses assumed tolerance-level residues, 100% CT, DEEM (ver. 7.81) default processing factors for all commodities excluding apple, pear, and grape juice (0.11x); grape, raisin (2.7x); orange, grapefruit, tangerine, lemon, and lime juice (0.06x); tomato paste (1.0x) and puree (1.0x); dried plum (1.0x); and peppermint and spearmint oil (0.08x).  These analyses are considered very conservative and could be refined through the use of anticipated-residue estimates (ARs) for all commodities, percent market share data for the proposed commodities, %CT data for registered commodities, and/or additional empirical processing factors.  However, at this time refinement is not necessary.


 VIII.  Conclusions
 
The acute and chronic dietary exposure and risk assessments were conducted using DEEM-FCID, ver. 3.16.  DEEM-FCID incorporates food consumption data from the USDA's NHANES/WWEIA.  

Separate acute dietary risk analyses were conducted for females 13-49 years old and for the general U.S. population, as separate endpoints of concern attributable to a single dose were identified.  Both acute analyses assumed tolerance-level residues, 100% CT, DEEM (ver. 7.81) default processing factors for all commodities excluding apple, pear, and grape juice (0.11x); grape, raisin (2.7x); orange, grapefruit, tangerine, lemon, and lime juice (0.06x); tomato paste (1.0x) and puree (1.0x); dried plum (1.0x); and peppermint and spearmint oil (0.08x).  The acute analyses also incorporated the drinking water estimates provided by EFED.  The EDWCs were unrefined estimates for surface water calculated using the Provisional Cranberry Model for fenpyroximate and its metabolites (an EDWC of 0.043 ppm was used in the acute analyses).  The resulting acute food plus drinking water risk estimates are not of concern to HED (<100% aPAD) at the 95[th] percentile of the exposure distribution for females 13 to 49 years old or the general U.S. population.  The resulting acute risk estimate is 13% of the aPAD at the 95[th] percentile of the exposure distribution for females 13 to 49 years old.  The highest acute exposure estimate for the U.S. population or population subgroup is children 1-2 years old, which resulted in a risk estimate of 6.2% aPAD.

The chronic analysis assumed tolerance-level residues, 100% CT, DEEM (ver. 7.81) default processing factors for most commodities (see above).  The chronic analysis also incorporated the drinking water estimates provided by EFED.  The EDWCs were unrefined estimates for surface water calculated using the Provisional Cranberry Model for fenpyroximate and its metabolites (an EDWC of 0.0086 ppm was used in the chronic analysis).  The resulting chronic risk estimates are not of concern to HED.  The most highly exposed population was children 1-2 years old utilizing 15% of the cPAD.


Attachments
 Attachment 1:  DEEM-FCID Acute Food + Drinking Water Residue Input File.
 Attachment 2:  DEEM-FCID Acute Exposure Estimates for Females 13-49 Years Old.
 Attachment 3:  DEEM-FCID Acute Exposure Estimates for the General U.S. Population Subgroup.
 Attachment 4:  DEEM-FCID Chronic Food + Drinking Water Residue Input File.
 Attachment 5:  DEEM-FCID Chronic Exposure Estimates.


























cc:  G. Kramer (RAB1)
RDI:  DE SAC Reviewers (28-JAN-2013)
G.F. Kramer:S10957:PY-S:(703)305-5079:7509P:RAB1
    Attachment 1:  DEEM-FCID Acute Food + Drinking Water Residue Input File.
                                       	
Filename: C:\Documents and Settings\gkramer\My Documents\Gk\#$Fenpyroximate\129131a.R08
Chemical: Fenpyroximate
RfD(Chronic): .05 mg/kg bw/day  NOEL(Chronic): 0 mg/kg bw/day
RfD(Acute): .375 mg/kg bw/day  NOEL(Acute):  0 mg/kg bw/day
Date created/last modified: 01-24-2013/14:17:01       Program ver. 3.16, 03-08-d
Comment: New uses; added additional acute endpt. for general population
-----------------------------------------------------------------------------------
   EPA     Crop                                   Def Res     Adj.Factors   Comment
   Code     Grp  Commodity Name                    (ppm)       #1    #2   
---------- ---- -------------------------------  ----------  ------ ------  -------
0103015000 1CD  Arrowroot, flour                   0.100000   1.000  1.000  
0103015001 1CD  Arrowroot, flour-babyfood          0.100000   1.000  1.000  
0103017000 1CD  Artichoke, Jerusalem               0.100000   1.000  1.000  
0103082000 1CD  Cassava                            0.100000   1.000  1.000  
0103082001 1CD  Cassava-babyfood                   0.100000   1.000  1.000  
0103139000 1CD  Dasheen, corm                      0.100000   1.000  1.000  
0103166000 1CD  Ginger                             0.100000   1.000  1.000  
0103166001 1CD  Ginger-babyfood                    0.100000   1.000  1.000  
0103167000 1CD  Ginger, dried                      0.100000   1.000  1.000  
0103296000 1C   Potato, chips                      0.100000   1.000  1.000  
0103297000 1C   Potato, dry (granules/ flakes)     0.100000   6.500  1.000  
0103297001 1C   Potato, dry (granules/ flakes)-b   0.100000   6.500  1.000  
0103298000 1C   Potato, flour                      0.100000   6.500  1.000  
0103298001 1C   Potato, flour-babyfood             0.100000   6.500  1.000  
0103299000 1C   Potato, tuber, w/peel              0.100000   1.000  1.000  
0103299001 1C   Potato, tuber, w/peel-babyfood     0.100000   1.000  1.000  
0103300000 1C   Potato, tuber, w/o peel            0.100000   1.000  1.000  
0103300001 1C   Potato, tuber, w/o peel-babyfood   0.100000   1.000  1.000  
0103366000 1CD  Sweet potato                       0.100000   1.000  1.000  
0103366001 1CD  Sweet potato-babyfood              0.100000   1.000  1.000  
0103371000 1CD  Tanier, corm                       0.100000   1.000  1.000  
0103387000 1CD  Turmeric                           0.100000   1.000  1.000  
0103406000 1CD  Yam, true                          0.100000   1.000  1.000  
0103407000 1CD  Yam bean                           0.100000   1.000  1.000  
0601043000 6A   Bean, snap, succulent              0.400000   1.000  1.000  
0601043001 6A   Bean, snap, succulent-babyfood     0.400000   1.000  1.000  
0801374000 8A   Tomatillo                          0.200000   1.000  1.000  
0801375000 8A   Tomato                             0.200000   1.000  1.000  
0801375001 8A   Tomato-babyfood                    0.200000   1.000  1.000  
0801376000 8A   Tomato, paste                      0.200000   1.000  1.000  
0801376001 8A   Tomato, paste-babyfood             0.200000   1.000  1.000  
0801377000 8A   Tomato, puree                      0.200000   1.000  1.000  
0801377001 8A   Tomato, puree-babyfood             0.200000   1.000  1.000  
0801378000 8A   Tomato, dried                      0.200000  14.300  1.000  
0801378001 8A   Tomato, dried-babyfood             0.200000  14.300  1.000  
0801379000 8A   Tomato, juice                      0.200000   1.500  1.000  
0801380000 8A   Tomato, Tree                       0.200000   1.000  1.000  
0802148000 8BC  Eggplant                           0.200000   1.000  1.000  
0802234000 8BC  Okra                               0.200000   1.000  1.000  
0802270000 8B   Pepper, bell                       0.200000   1.000  1.000  
0802270001 8B   Pepper, bell-babyfood              0.200000   1.000  1.000  
0802271000 8B   Pepper, bell, dried                0.200000   1.000  1.000  
0802271001 8B   Pepper, bell, dried-babyfood       0.200000   1.000  1.000  
0802272000 8BC  Pepper, nonbell                    0.200000   1.000  1.000  
0802272001 8BC  Pepper, nonbell-babyfood           0.200000   1.000  1.000  
0802273000 8BC  Pepper, nonbell, dried             0.200000   1.000  1.000  
0901075000 9A   Cantaloupe                         0.100000   1.000  1.000  
0901187000 9A   Honeydew melon                     0.100000   1.000  1.000  
0901399000 9A   Watermelon                         0.100000   1.000  1.000  
0901400000 9A   Watermelon, juice                  0.100000   1.000  1.000  
0902135000 9B   Cucumber                           0.400000   1.000  1.000  
1001106000 10A  Citron                             0.500000   1.000  1.000  
1001107000 10A  Citrus hybrids                     0.500000   1.000  1.000  
1001108000 10A  Citrus, oil                       10.000000   1.000  1.000  
1001240000 10A  Orange                             0.500000   1.000  1.000  
1001241000 10A  Orange, juice                      0.500000   0.060  1.000  
1001241001 10A  Orange, juice-babyfood             0.500000   0.060  1.000  
1001242000 10A  Orange, peel                       0.500000   1.000  1.000  
1001369000 10A  Tangerine                          0.500000   1.000  1.000  
1001370000 10A  Tangerine, juice                   0.500000   0.060  1.000  
1002197000 10B  Kumquat                            0.500000   1.000  1.000  
1002199000 10B  Lemon                              0.500000   1.000  1.000  
1002200000 10B  Lemon, juice                       0.500000   0.060  1.000  
1002200001 10B  Lemon, juice-babyfood              0.500000   0.060  1.000  
1002201000 10B  Lemon, peel                        0.500000   1.000  1.000  
1002206000 10B  Lime                               0.500000   1.000  1.000  
1002207000 10B  Lime, juice                        0.500000   0.060  1.000  
1002207001 10B  Lime, juice-babyfood               0.500000   0.060  1.000  
1003180000 10C  Grapefruit                         0.500000   1.000  1.000  
1003181000 10C  Grapefruit, juice                  0.500000   0.060  1.000  
1003307000 10C  Pummelo                            0.500000   1.000  1.000  
1100007000 11   Apple, fruit with peel             0.300000   1.000  1.000  
1100008000 11   Apple, peeled fruit                0.300000   1.000  1.000  
1100008001 11   Apple, peeled fruit-babyfood       0.300000   1.000  1.000  
1100009000 11   Apple, dried                       0.300000   8.000  1.000  
1100009001 11   Apple, dried-babyfood              0.300000   8.000  1.000  
1100010000 11   Apple, juice                       0.300000   0.110  1.000  
1100010001 11   Apple, juice-babyfood              0.300000   0.110  1.000  
1100011000 11   Apple, sauce                       0.300000   1.000  1.000  
1100011001 11   Apple, sauce-babyfood              0.300000   1.000  1.000  
1100129000 11   Crabapple                          0.300000   1.000  1.000  
1100173500 11   Goji berry                         0.200000   1.000  1.000  
1100210000 11   Loquat                             0.300000   1.000  1.000  
1100266000 11   Pear                               0.300000   1.000  1.000  
1100266001 11   Pear-babyfood                      0.300000   1.000  1.000  
1100267000 11   Pear, dried                        0.300000   6.250  1.000  
1100268000 11   Pear, juice                        0.300000   0.110  1.000  
1100268001 11   Pear, juice-babyfood               0.300000   0.110  1.000  
1100310000 11   Quince                             0.300000   1.000  1.000  
1201090000 12A  Cherry                             2.000000   1.000  1.000  
1201090001 12A  Cherry-babyfood                    2.000000   1.000  1.000  
1201091000 12A  Cherry, juice                      2.000000   1.500  1.000  
1201091001 12A  Cherry, juice-babyfood             2.000000   1.500  1.000  
1202012000 12B  Apricot                            2.000000   1.000  1.000  
1202012001 12B  Apricot-babyfood                   2.000000   1.000  1.000  
1202013000 12B  Apricot, dried                     2.000000   6.000  1.000  
1202014000 12B  Apricot, juice                     2.000000   1.000  1.000  
1202014001 12B  Apricot, juice-babyfood            2.000000   1.000  1.000  
1202230000 12B  Nectarine                          2.000000   1.000  1.000  
1202260000 12B  Peach                              2.000000   1.000  1.000  
1202260001 12B  Peach-babyfood                     2.000000   1.000  1.000  
1202261000 12B  Peach, dried                       2.000000   7.000  1.000  
1202261001 12B  Peach, dried-babyfood              2.000000   7.000  1.000  
1202262000 12B  Peach, juice                       2.000000   1.000  1.000  
1202262001 12B  Peach, juice-babyfood              2.000000   1.000  1.000  
1203285000 12C  Plum                               2.000000   1.000  1.000  
1203285001 12C  Plum-babyfood                      2.000000   1.000  1.000  
1203286000 12C  Plum, prune, fresh                 2.000000   1.000  1.000  
1203286001 12C  Plum, prune, fresh-babyfood        2.000000   1.000  1.000  
1203287000 12C  Plum, prune, dried                 2.000000   1.000  1.000  
1203287001 12C  Plum, prune, dried-babyfood        2.000000   1.000  1.000  
1203288000 12C  Plum, prune, juice                 2.000000   1.400  1.000  
1203288001 12C  Plum, prune, juice-babyfood        2.000000   1.400  1.000  
1302057000 13B  Blueberry                          1.000000   1.000  1.000  
1302057001 13B  Blueberry-babyfood                 1.000000   1.000  1.000  
1302174000 13B  Gooseberry                         1.000000   1.000  1.000  
1304175000 13D  Grape                              1.000000   1.000  1.000  
1304176000 13D  Grape, juice                       1.000000   0.110  1.000  
1304176001 13D  Grape, juice-babyfood              1.000000   0.110  1.000  
1304179000 13D  Grape, wine and sherry             1.000000   1.000  1.000  
1307130000 13G  Cranberry                          1.000000   1.000  1.000  
1307130001 13G  Cranberry-babyfood                 1.000000   1.000  1.000  
1307131000 13G  Cranberry, dried                   1.000000   1.000  1.000  
1307132000 13G  Cranberry, juice                   1.000000   1.100  1.000  
1307132001 13G  Cranberry, juice-babyfood          1.000000   1.100  1.000  
1307359000 13G  Strawberry                         1.000000   1.000  1.000  
1307359001 13G  Strawberry-babyfood                1.000000   1.000  1.000  
1307360000 13G  Strawberry, juice                  1.000000   1.000  1.000  
1307360001 13G  Strawberry, juice-babyfood         1.000000   1.000  1.000  
1400003000 14   Almond                             0.100000   1.000  1.000  
1400003001 14   Almond-babyfood                    0.100000   1.000  1.000  
1400004000 14   Almond, oil                        0.100000   1.000  1.000  
1400004001 14   Almond, oil-babyfood               0.100000   1.000  1.000  
1400059000 14   Brazil nut                         0.100000   1.000  1.000  
1400068000 14   Butternut                          0.100000   1.000  1.000  
1400081000 14   Cashew                             0.100000   1.000  1.000  
1400092000 14   Chestnut                           0.100000   1.000  1.000  
1400155000 14   Hazelnut                           0.100000   1.000  1.000  
1400156000 14   Hazelnut, oil                      0.100000   1.000  1.000  
1400185000 14   Hickory nut                        0.100000   1.000  1.000  
1400213000 14   Macadamia nut                      0.100000   1.000  1.000  
1400269000 14   Pecan                              0.100000   1.000  1.000  
1400282000 14   Pistachio                          0.100000   1.000  1.000  
1400391000 14   Walnut                             0.100000   1.000  1.000  
1500120000 15   Corn, field, flour                 0.020000   1.000  1.000  
1500120001 15   Corn, field, flour-babyfood        0.020000   1.000  1.000  
1500121000 15   Corn, field, meal                  0.020000   1.000  1.000  
1500121001 15   Corn, field, meal-babyfood         0.020000   1.000  1.000  
1500122000 15   Corn, field, bran                  0.020000   1.000  1.000  
1500123000 15   Corn, field, starch                0.020000   1.000  1.000  
1500123001 15   Corn, field, starch-babyfood       0.020000   1.000  1.000  
1500124000 15   Corn, field, syrup                 0.020000   1.500  1.000  
1500124001 15   Corn, field, syrup-babyfood        0.020000   1.500  1.000  
1500125000 15   Corn, field, oil                   0.050000   1.000  1.000  
1500125001 15   Corn, field, oil-babyfood          0.050000   1.000  1.000  
1500126000 15   Corn, pop                          0.020000   1.000  1.000  
2003128000 20C  Cottonseed, oil                    0.100000   1.000  1.000  
2003128001 20C  Cottonseed, oil-babyfood           0.100000   1.000  1.000  
3100044000 31   Beef, meat                         0.030000   1.000  1.000  
3100044001 31   Beef, meat-babyfood                0.030000   1.000  1.000  
3100045000 31   Beef, meat, dried                  0.030000   1.920  1.000  
3100046000 31   Beef, meat byproducts              0.030000   1.000  1.000  
3100046001 31   Beef, meat byproducts-babyfood     0.030000   1.000  1.000  
3100047000 31   Beef, fat                          0.030000   1.000  1.000  
3100047001 31   Beef, fat-babyfood                 0.030000   1.000  1.000  
3100048000 31   Beef, kidney                       0.250000   1.000  1.000  
3100049000 31   Beef, liver                        0.250000   1.000  1.000  
3100049001 31   Beef, liver-babyfood               0.250000   1.000  1.000  
3200169000 32   Goat, meat                         0.030000   1.000  1.000  
3200170000 32   Goat, meat byproducts              0.030000   1.000  1.000  
3200171000 32   Goat, fat                          0.030000   1.000  1.000  
3200172000 32   Goat, kidney                       0.250000   1.000  1.000  
3200173000 32   Goat, liver                        0.250000   1.000  1.000  
3300189000 33   Horse, meat                        0.030000   1.000  1.000  
3500339000 35   Sheep, meat                        0.030000   1.000  1.000  
3500339001 35   Sheep, meat-babyfood               0.030000   1.000  1.000  
3500340000 35   Sheep, meat byproducts             0.030000   1.000  1.000  
3500341000 35   Sheep, fat                         0.030000   1.000  1.000  
3500341001 35   Sheep, fat-babyfood                0.030000   1.000  1.000  
3500342000 35   Sheep, kidney                      0.250000   1.000  1.000  
3500343000 35   Sheep, liver                       0.250000   1.000  1.000  
3600222000 36   Milk, fat                          0.015000   1.000  1.000  
3600222001 36   Milk, fat-baby food/infant formu   0.015000   1.000  1.000  
3600223000 36   Milk, nonfat solids                0.015000   1.000  1.000  
3600223001 36   Milk, nonfat solids-baby food/in   0.015000   1.000  1.000  
3600224000 36   Milk, water                        0.015000   1.000  1.000  
3600224001 36   Milk, water-babyfood/infant form   0.015000   1.000  1.000  
3600225001 36   Milk, sugar (lactose)-baby food/   0.015000   1.000  1.000  
8601000000 86A  Water, direct, all sources
                   110-Uncooked; Fresh or N/S; Cook Meth N/S
                                                   0.043000   1.000  1.000  
8602000000 86B  Water, indirect, all sources       0.043000   1.000  1.000  
9500020000 O    Avocado                            0.150000   1.000  1.000  
9500074000 O    Canistel                           0.150000   1.000  1.000  
9500177000 O    Grape, leaves                      1.000000   1.000  1.000  
9500178000 O    Grape, raisin                      1.000000   2.700  1.000  
9500186000 O    Honey                              0.100000   1.000  1.000  
9500186001 O    Honey-babyfood                     0.100000   1.000  1.000  
9500188000 O    Hop                               10.000000   1.000  1.000  
9500215000 O    Mango                              0.150000   1.000  1.000  
9500215001 O    Mango-babyfood                     0.150000   1.000  1.000  
9500216000 O    Mango, dried                       0.150000   1.000  1.000  
9500217000 O    Mango, juice                       0.150000   1.000  1.000  
9500217001 O    Mango, juice-babyfood              0.150000   1.000  1.000  
9500245000 O    Papaya                             0.150000   1.000  1.000  
9500245001 O    Papaya-babyfood                    0.150000   1.000  1.000  
9500246000 O    Papaya, dried                      0.150000   1.800  1.000  
9500247000 O    Papaya, juice                      0.150000   1.500  1.000  
9500275000 O    Peppermint                         7.000000   1.000  1.000  
9500276000 O    Peppermint, oil                    7.000000   0.080  1.000  
9500333000 O    Sapote, Mamey                      0.150000   1.000  1.000  
9500352000 O    Spearmint                          7.000000   1.000  1.000  
9500353000 O    Spearmint, oil                     7.000000   0.080  1.000  
9500372000 O    Tea, dried                        20.000000   1.000  1.000  
9500373000 O    Tea, instant                      20.000000   1.000  1.000  
 Attachment 2:  DEEM-FCID Acute Exposure Estimates for Females 13 to 49 Years Old.

EPA                                                         Ver. 3.16, 03-08-d
DEEM-FCID ACUTE Analysis for FENPYROXIMATE               NHANES 2003-2008 2-Day
Residue file: 129131a.R08                             Adjustment factor #2 used.
Analysis Date: 02-01-2013/11:22:40    Residue file dated: 02-01-2013/11:17:00
RAC/FF intake summed over 24 hours
Run Comment: "New uses; added additional acute endpt. for general population"
===============================================================================

Summary calculations--per capita:

                   95th Percentile      99th Percentile     99.9th Percentile
                   Exposure   % aRfD    Exposure   % aRfD    Exposure   % aRfD 
                  ---------- --------  ---------- --------  ---------- --------
Female 13-49:
                    0.006685    13.37    0.010890    21.78    0.018888    37.78 
Attachment 3:  DEEM-FCID Acute Exposure Estimates for the General U.S. Population Subgroups.

EPA                                                         Ver. 3.16, 03-08-d
DEEM-FCID ACUTE Analysis for FENPYROXIMATE               NHANES 2003-2008 2-Day
Residue file: 129131a.R08                             Adjustment factor #2 used.
Analysis Date: 02-01-2013/11:21:36    Residue file dated: 02-01-2013/11:17:00
RAC/FF intake summed over 24 hours
Run Comment: "New uses; added additional acute endpt. for general population"
===============================================================================

Summary calculations--per capita:

                   95th Percentile      99th Percentile     99.9th Percentile
                   Exposure   % aRfD    Exposure   % aRfD    Exposure   % aRfD 
                  ---------- --------  ---------- --------  ---------- --------
Total US Population:
                    0.008312     2.22    0.015331     4.09    0.031367     8.36 
All Infants:
                    0.022585     6.02    0.038089    10.16    0.064723    17.26 
Children 1-2:
                    0.023191     6.18    0.035415     9.44    0.059443    15.85 
Children 3-5:
                    0.016596     4.43    0.023834     6.36    0.041924    11.18 
Children 6-12:
                    0.009835     2.62    0.017059     4.55    0.029926     7.98 
Youth 13-19:
                    0.005336     1.42    0.009026     2.41    0.018289     4.88 
Adults 20-49:
                    0.006565     1.75    0.010483     2.80    0.018315     4.88 
Adults 50-99:
                    0.006917     1.84    0.011416     3.04    0.017527     4.67 


   Attachment 4:  DEEM-FCID Chronic Food + Drinking Water Residue Input File.

Filename: C:\Documents and Settings\gkramer\My Documents\Gk\#$Fenpyroximate\129131C.R08
Chemical: Fenpyroximate
RfD(Chronic): .05 mg/kg bw/day  NOEL(Chronic): 0 mg/kg bw/day
RfD(Acute): .375 mg/kg bw/day  NOEL(Acute):  0 mg/kg bw/day
Date created/last modified: 02-01-2013/11:15:04       Program ver. 3.16, 03-08-d
Comment: New uses; added additional acute endpt. for general population
-----------------------------------------------------------------------------------
   EPA     Crop                                   Def Res     Adj.Factors   Comment
   Code     Grp  Commodity Name                    (ppm)       #1    #2   
---------- ---- -------------------------------  ----------  ------ ------  -------
0103015000 1CD  Arrowroot, flour                   0.100000   1.000  1.000  
0103015001 1CD  Arrowroot, flour-babyfood          0.100000   1.000  1.000  
0103017000 1CD  Artichoke, Jerusalem               0.100000   1.000  1.000  
0103082000 1CD  Cassava                            0.100000   1.000  1.000  
0103082001 1CD  Cassava-babyfood                   0.100000   1.000  1.000  
0103139000 1CD  Dasheen, corm                      0.100000   1.000  1.000  
0103166000 1CD  Ginger                             0.100000   1.000  1.000  
0103166001 1CD  Ginger-babyfood                    0.100000   1.000  1.000  
0103167000 1CD  Ginger, dried                      0.100000   1.000  1.000  
0103296000 1C   Potato, chips                      0.100000   1.000  1.000  
0103297000 1C   Potato, dry (granules/ flakes)     0.100000   6.500  1.000  
0103297001 1C   Potato, dry (granules/ flakes)-b   0.100000   6.500  1.000  
0103298000 1C   Potato, flour                      0.100000   6.500  1.000  
0103298001 1C   Potato, flour-babyfood             0.100000   6.500  1.000  
0103299000 1C   Potato, tuber, w/peel              0.100000   1.000  1.000  
0103299001 1C   Potato, tuber, w/peel-babyfood     0.100000   1.000  1.000  
0103300000 1C   Potato, tuber, w/o peel            0.100000   1.000  1.000  
0103300001 1C   Potato, tuber, w/o peel-babyfood   0.100000   1.000  1.000  
0103366000 1CD  Sweet potato                       0.100000   1.000  1.000  
0103366001 1CD  Sweet potato-babyfood              0.100000   1.000  1.000  
0103371000 1CD  Tanier, corm                       0.100000   1.000  1.000  
0103387000 1CD  Turmeric                           0.100000   1.000  1.000  
0103406000 1CD  Yam, true                          0.100000   1.000  1.000  
0103407000 1CD  Yam bean                           0.100000   1.000  1.000  
0601043000 6A   Bean, snap, succulent              0.400000   1.000  1.000  
0601043001 6A   Bean, snap, succulent-babyfood     0.400000   1.000  1.000  
0801374000 8A   Tomatillo                          0.200000   1.000  1.000  
0801375000 8A   Tomato                             0.200000   1.000  1.000  
0801375001 8A   Tomato-babyfood                    0.200000   1.000  1.000  
0801376000 8A   Tomato, paste                      0.200000   1.000  1.000  
0801376001 8A   Tomato, paste-babyfood             0.200000   1.000  1.000  
0801377000 8A   Tomato, puree                      0.200000   1.000  1.000  
0801377001 8A   Tomato, puree-babyfood             0.200000   1.000  1.000  
0801378000 8A   Tomato, dried                      0.200000  14.300  1.000  
0801378001 8A   Tomato, dried-babyfood             0.200000  14.300  1.000  
0801379000 8A   Tomato, juice                      0.200000   1.500  1.000  
0801380000 8A   Tomato, Tree                       0.200000   1.000  1.000  
0802148000 8BC  Eggplant                           0.200000   1.000  1.000  
0802234000 8BC  Okra                               0.200000   1.000  1.000  
0802270000 8B   Pepper, bell                       0.200000   1.000  1.000  
0802270001 8B   Pepper, bell-babyfood              0.200000   1.000  1.000  
0802271000 8B   Pepper, bell, dried                0.200000   1.000  1.000  
0802271001 8B   Pepper, bell, dried-babyfood       0.200000   1.000  1.000  
0802272000 8BC  Pepper, nonbell                    0.200000   1.000  1.000  
0802272001 8BC  Pepper, nonbell-babyfood           0.200000   1.000  1.000  
0802273000 8BC  Pepper, nonbell, dried             0.200000   1.000  1.000  
0901075000 9A   Cantaloupe                         0.100000   1.000  1.000  
0901187000 9A   Honeydew melon                     0.100000   1.000  1.000  
0901399000 9A   Watermelon                         0.100000   1.000  1.000  
0901400000 9A   Watermelon, juice                  0.100000   1.000  1.000  
0902135000 9B   Cucumber                           0.400000   1.000  1.000  
1001106000 10A  Citron                             0.500000   1.000  1.000  
1001107000 10A  Citrus hybrids                     0.500000   1.000  1.000  
1001108000 10A  Citrus, oil                       10.000000   1.000  1.000  
1001240000 10A  Orange                             0.500000   1.000  1.000  
1001241000 10A  Orange, juice                      0.500000   0.060  1.000  
1001241001 10A  Orange, juice-babyfood             0.500000   0.060  1.000  
1001242000 10A  Orange, peel                       0.500000   1.000  1.000  
1001369000 10A  Tangerine                          0.500000   1.000  1.000  
1001370000 10A  Tangerine, juice                   0.500000   0.060  1.000  
1002197000 10B  Kumquat                            0.500000   1.000  1.000  
1002199000 10B  Lemon                              0.500000   1.000  1.000  
1002200000 10B  Lemon, juice                       0.500000   0.060  1.000  
1002200001 10B  Lemon, juice-babyfood              0.500000   0.060  1.000  
1002201000 10B  Lemon, peel                        0.500000   1.000  1.000  
1002206000 10B  Lime                               0.500000   1.000  1.000  
1002207000 10B  Lime, juice                        0.500000   0.060  1.000  
1002207001 10B  Lime, juice-babyfood               0.500000   0.060  1.000  
1003180000 10C  Grapefruit                         0.500000   1.000  1.000  
1003181000 10C  Grapefruit, juice                  0.500000   0.060  1.000  
1003307000 10C  Pummelo                            0.500000   1.000  1.000  
1100007000 11   Apple, fruit with peel             0.300000   1.000  1.000  
1100008000 11   Apple, peeled fruit                0.300000   1.000  1.000  
1100008001 11   Apple, peeled fruit-babyfood       0.300000   1.000  1.000  
1100009000 11   Apple, dried                       0.300000   8.000  1.000  
1100009001 11   Apple, dried-babyfood              0.300000   8.000  1.000  
1100010000 11   Apple, juice                       0.300000   0.110  1.000  
1100010001 11   Apple, juice-babyfood              0.300000   0.110  1.000  
1100011000 11   Apple, sauce                       0.300000   1.000  1.000  
1100011001 11   Apple, sauce-babyfood              0.300000   1.000  1.000  
1100129000 11   Crabapple                          0.300000   1.000  1.000  
1100173500 11   Goji berry                         0.200000   1.000  1.000  
1100210000 11   Loquat                             0.300000   1.000  1.000  
1100266000 11   Pear                               0.300000   1.000  1.000  
1100266001 11   Pear-babyfood                      0.300000   1.000  1.000  
1100267000 11   Pear, dried                        0.300000   6.250  1.000  
1100268000 11   Pear, juice                        0.300000   0.110  1.000  
1100268001 11   Pear, juice-babyfood               0.300000   0.110  1.000  
1100310000 11   Quince                             0.300000   1.000  1.000  
1201090000 12A  Cherry                             2.000000   1.000  1.000  
1201090001 12A  Cherry-babyfood                    2.000000   1.000  1.000  
1201091000 12A  Cherry, juice                      2.000000   1.500  1.000  
1201091001 12A  Cherry, juice-babyfood             2.000000   1.500  1.000  
1202012000 12B  Apricot                            2.000000   1.000  1.000  
1202012001 12B  Apricot-babyfood                   2.000000   1.000  1.000  
1202013000 12B  Apricot, dried                     2.000000   6.000  1.000  
1202014000 12B  Apricot, juice                     2.000000   1.000  1.000  
1202014001 12B  Apricot, juice-babyfood            2.000000   1.000  1.000  
1202230000 12B  Nectarine                          2.000000   1.000  1.000  
1202260000 12B  Peach                              2.000000   1.000  1.000  
1202260001 12B  Peach-babyfood                     2.000000   1.000  1.000  
1202261000 12B  Peach, dried                       2.000000   7.000  1.000  
1202261001 12B  Peach, dried-babyfood              2.000000   7.000  1.000  
1202262000 12B  Peach, juice                       2.000000   1.000  1.000  
1202262001 12B  Peach, juice-babyfood              2.000000   1.000  1.000  
1203285000 12C  Plum                               2.000000   1.000  1.000  
1203285001 12C  Plum-babyfood                      2.000000   1.000  1.000  
1203286000 12C  Plum, prune, fresh                 2.000000   1.000  1.000  
1203286001 12C  Plum, prune, fresh-babyfood        2.000000   1.000  1.000  
1203287000 12C  Plum, prune, dried                 2.000000   1.000  1.000  
1203287001 12C  Plum, prune, dried-babyfood        2.000000   1.000  1.000  
1203288000 12C  Plum, prune, juice                 2.000000   1.400  1.000  
1203288001 12C  Plum, prune, juice-babyfood        2.000000   1.400  1.000  
1302057000 13B  Blueberry                          1.000000   1.000  1.000  
1302057001 13B  Blueberry-babyfood                 1.000000   1.000  1.000  
1302174000 13B  Gooseberry                         1.000000   1.000  1.000  
1304175000 13D  Grape                              1.000000   1.000  1.000  
1304176000 13D  Grape, juice                       1.000000   0.110  1.000  
1304176001 13D  Grape, juice-babyfood              1.000000   0.110  1.000  
1304179000 13D  Grape, wine and sherry             1.000000   1.000  1.000  
1307130000 13G  Cranberry                          1.000000   1.000  1.000  
1307130001 13G  Cranberry-babyfood                 1.000000   1.000  1.000  
1307131000 13G  Cranberry, dried                   1.000000   1.000  1.000  
1307132000 13G  Cranberry, juice                   1.000000   1.100  1.000  
1307132001 13G  Cranberry, juice-babyfood          1.000000   1.100  1.000  
1307359000 13G  Strawberry                         1.000000   1.000  1.000  
1307359001 13G  Strawberry-babyfood                1.000000   1.000  1.000  
1307360000 13G  Strawberry, juice                  1.000000   1.000  1.000  
1307360001 13G  Strawberry, juice-babyfood         1.000000   1.000  1.000  
1400003000 14   Almond                             0.100000   1.000  1.000  
1400003001 14   Almond-babyfood                    0.100000   1.000  1.000  
1400004000 14   Almond, oil                        0.100000   1.000  1.000  
1400004001 14   Almond, oil-babyfood               0.100000   1.000  1.000  
1400059000 14   Brazil nut                         0.100000   1.000  1.000  
1400068000 14   Butternut                          0.100000   1.000  1.000  
1400081000 14   Cashew                             0.100000   1.000  1.000  
1400092000 14   Chestnut                           0.100000   1.000  1.000  
1400155000 14   Hazelnut                           0.100000   1.000  1.000  
1400156000 14   Hazelnut, oil                      0.100000   1.000  1.000  
1400185000 14   Hickory nut                        0.100000   1.000  1.000  
1400213000 14   Macadamia nut                      0.100000   1.000  1.000  
1400269000 14   Pecan                              0.100000   1.000  1.000  
1400282000 14   Pistachio                          0.100000   1.000  1.000  
1400391000 14   Walnut                             0.100000   1.000  1.000  
1500120000 15   Corn, field, flour                 0.020000   1.000  1.000  
1500120001 15   Corn, field, flour-babyfood        0.020000   1.000  1.000  
1500121000 15   Corn, field, meal                  0.020000   1.000  1.000  
1500121001 15   Corn, field, meal-babyfood         0.020000   1.000  1.000  
1500122000 15   Corn, field, bran                  0.020000   1.000  1.000  
1500123000 15   Corn, field, starch                0.020000   1.000  1.000  
1500123001 15   Corn, field, starch-babyfood       0.020000   1.000  1.000  
1500124000 15   Corn, field, syrup                 0.020000   1.500  1.000  
1500124001 15   Corn, field, syrup-babyfood        0.020000   1.500  1.000  
1500125000 15   Corn, field, oil                   0.050000   1.000  1.000  
1500125001 15   Corn, field, oil-babyfood          0.050000   1.000  1.000  
1500126000 15   Corn, pop                          0.020000   1.000  1.000  
2003128000 20C  Cottonseed, oil                    0.100000   1.000  1.000  
2003128001 20C  Cottonseed, oil-babyfood           0.100000   1.000  1.000  
3100044000 31   Beef, meat                         0.030000   1.000  1.000  
3100044001 31   Beef, meat-babyfood                0.030000   1.000  1.000  
3100045000 31   Beef, meat, dried                  0.030000   1.920  1.000  
3100046000 31   Beef, meat byproducts              0.030000   1.000  1.000  
3100046001 31   Beef, meat byproducts-babyfood     0.030000   1.000  1.000  
3100047000 31   Beef, fat                          0.030000   1.000  1.000  
3100047001 31   Beef, fat-babyfood                 0.030000   1.000  1.000  
3100048000 31   Beef, kidney                       0.250000   1.000  1.000  
3100049000 31   Beef, liver                        0.250000   1.000  1.000  
3100049001 31   Beef, liver-babyfood               0.250000   1.000  1.000  
3200169000 32   Goat, meat                         0.030000   1.000  1.000  
3200170000 32   Goat, meat byproducts              0.030000   1.000  1.000  
3200171000 32   Goat, fat                          0.030000   1.000  1.000  
3200172000 32   Goat, kidney                       0.250000   1.000  1.000  
3200173000 32   Goat, liver                        0.250000   1.000  1.000  
3300189000 33   Horse, meat                        0.030000   1.000  1.000  
3500339000 35   Sheep, meat                        0.030000   1.000  1.000  
3500339001 35   Sheep, meat-babyfood               0.030000   1.000  1.000  
3500340000 35   Sheep, meat byproducts             0.030000   1.000  1.000  
3500341000 35   Sheep, fat                         0.030000   1.000  1.000  
3500341001 35   Sheep, fat-babyfood                0.030000   1.000  1.000  
3500342000 35   Sheep, kidney                      0.250000   1.000  1.000  
3500343000 35   Sheep, liver                       0.250000   1.000  1.000  
3600222000 36   Milk, fat                          0.015000   1.000  1.000  
3600222001 36   Milk, fat-baby food/infant formu   0.015000   1.000  1.000  
3600223000 36   Milk, nonfat solids                0.015000   1.000  1.000  
3600223001 36   Milk, nonfat solids-baby food/in   0.015000   1.000  1.000  
3600224000 36   Milk, water                        0.015000   1.000  1.000  
3600224001 36   Milk, water-babyfood/infant form   0.015000   1.000  1.000  
3600225001 36   Milk, sugar (lactose)-baby food/   0.015000   1.000  1.000  
8601000000 86A  Water, direct, all sources
                   110-Uncooked; Fresh or N/S; Cook Meth N/S
                                                   0.008600   1.000  1.000  
8602000000 86B  Water, indirect, all sources       0.008600   1.000  1.000  
9500020000 O    Avocado                            0.150000   1.000  1.000  
9500074000 O    Canistel                           0.150000   1.000  1.000  
9500177000 O    Grape, leaves                      1.000000   1.000  1.000  
9500178000 O    Grape, raisin                      1.000000   2.700  1.000  
9500186000 O    Honey                              0.100000   1.000  1.000  
9500186001 O    Honey-babyfood                     0.100000   1.000  1.000  
9500188000 O    Hop                               10.000000   1.000  1.000  
9500215000 O    Mango                              0.150000   1.000  1.000  
9500215001 O    Mango-babyfood                     0.150000   1.000  1.000  
9500216000 O    Mango, dried                       0.150000   1.000  1.000  
9500217000 O    Mango, juice                       0.150000   1.000  1.000  
9500217001 O    Mango, juice-babyfood              0.150000   1.000  1.000  
9500245000 O    Papaya                             0.150000   1.000  1.000  
9500245001 O    Papaya-babyfood                    0.150000   1.000  1.000  
9500246000 O    Papaya, dried                      0.150000   1.800  1.000  
9500247000 O    Papaya, juice                      0.150000   1.500  1.000  
9500275000 O    Peppermint                         7.000000   1.000  1.000  
9500276000 O    Peppermint, oil                    7.000000   0.080  1.000  
9500333000 O    Sapote, Mamey                      0.150000   1.000  1.000  
9500352000 O    Spearmint                          7.000000   1.000  1.000  
9500353000 O    Spearmint, oil                     7.000000   0.080  1.000  
9500372000 O    Tea, dried                        20.000000   1.000  1.000  
9500373000 O    Tea, instant                      20.000000   1.000  1.000   
              Attachment 5:  DEEM-FCID Chronic Exposure Estimates.

EPA                                                             Ver. 3.16, 03-08-d
DEEM-FCID Chronic analysis for FENPYROXIMATE               NHANES 2003-2008 2-day
Residue file name: C:\Documents and Settings\gkramer\My Documents\Gk\#$Fenpyroximate\129131C.R08
                                                     Adjustment factor #2 used.
Analysis Date 02-01-2013/11:19:11     Residue file dated: 02-01-2013/11:15:04
Reference dose (RfD, Chronic) = .05 mg/kg bw/day
COMMENT 1: New uses; added additional acute endpt. for general population
===============================================================================
                    Total exposure by population subgroup
-------------------------------------------------------------------------------

                                                    Total Exposure
                                         -----------------------------------
          Population                         mg/kg             Percent of   
           Subgroup                       body wt/day             Rfd       
--------------------------------------   -------------       ----------------
Total US Population                         0.002208                 4.4%
Hispanic                                    0.002196                 4.4%
Non-Hisp-White                              0.002285                 4.6%
Non-Hisp-Black                              0.001775                 3.5%
Non-Hisp-Other                              0.002235                 4.5%
Nursing Infants                             0.003063                 6.1%
Non-Nursing Infants                         0.005431                10.9%
Female 13+ PREG                             0.001848                 3.7%
Children 1-6                                0.005749                11.5%
Children 7-12                               0.002458                 4.9%
Male 13-19                                  0.001337                 2.7%
Female 13-19/NP                             0.001458                 2.9%
Male 20+                                    0.001755                 3.5%
Female 20+/NP                               0.001911                 3.8%
Seniors 55+                                 0.002081                 4.2%
All Infants                                 0.004700                 9.4%
Female 13-50                                0.001695                 3.4%
Children 1-2                                0.007336                14.7%
Children 3-5                                0.005098                10.2%
Children 6-12                               0.002723                 5.4%
Youth 13-19                                 0.001394                 2.8%
Adults 20-49                                0.001712                 3.4%
Adults 50-99                                0.002013                 4.0%
Female 13-49                                0.001693                 3.4%

-------------------------------------------------------------------------------
