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      	UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
       		WASHINGTON, D.C. 20460
      
      
      
      
                                  February 7, 2012
                                                                               
                             OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION
MEMORANDUM

SUBJECT:	Product Chemistry Scoping Document for the Registration Review of Methyl Nonyl Ketone.  

            Registration Review Case #:		3094
            PC Code:						044102
            CAS Numbers:					112-12-9
            Chemical Class:					Biochemical
                                                                  
FROM:		Jacob S Moore /s/ 2/7/12
            Biochemical Pesticides Branch
            Biopesticides & Pollution Prevention Division (7511P)

TO:			Leonard Cole, Regulatory Action Leader
            Biochemical Pesticides Branch
            Biopesticides & Pollution Prevention Division (7511P) 




ACTION REQUESTED
	A preliminary assessment of available information on product chemistry data associated with the biopesticide methyl nonyl ketone in support of the development of a registration review work plan.















Introduction
The EPA has made the determination that there is adequate information available on 2-undecanone, commonly known as methyl nonyl ketone, and does not foresee the need for additional biochemical pesticide product chemistry data for products that currently contain methyl nonyl ketone as the technical grade active ingredient.

Methyl nonyl ketone is currently formulated into 18 formulations registered with the Agency. Of these 18 registrations, 3 are manufacturing-use products and the remaining 15 are end-use products. The active ingredient has been registered since May 1966 and a Reregistration Eligibility Decision for methyl nonyl ketone was issued in July 1995. Methyl nonyl ketone is used as a dog and cat repellent and iris borer deterrent.

Concerning the product chemistry of methyl nonyl ketone, all biochemical pesticide data requirement for the technical grade active ingredient have been satisfied and are summarized in Table 2. While no further product chemistry data are necessary for the products currently registered, future registrations must adequately address all of the biochemical pesticides product chemistry data requirements.
.





Table 1. Product Identity and Composition for Methyl Nonyl Ketone
Common Name
Methyl Nonyl Ketone
Chemical Name, IUPAC
2-undecanone
Molecular Weight
170.29 g/mol
PC Code
044102
CAS Registry Number
112-12-9
Empirical Formula
C11H22O
Registration Review Case Number
Case Number
Chemical Structure
                                       



Product Chemistry Summary
The Agency has conducted a review of the available product chemistry data and information.  These data are summarized below.

Table 2. Biochemical Pesticides Product Chemistry Data Requirements for AVG
                                 Guideline No.
                       Physical and Chemical Properties
                                   Status[1]
                                     Value
                                     MRID/
                                    Source
830.1100
Product Identity and Composition
                                       A
Refer to Table 1.

830.1200
Description of starting materials, production and formulation process
                                       A
CBI

830.1400
Discussion of formation of impurities
                                       A
CBI

830.1700
Preliminary analysis
                                       A
CBI

830.6302
Color
                                       A
Colorless
RED
830.6303
Physical state (20°C)
                                       A
Liquid
RED
830.6304
Odor
                                       A
Slight acrid odor
RED
830.6313
Stability to normal and elevated temperatures, metals and metal ions
                                       A
Stable
RED
830.7000
pH
                                      N/A
See 40 CFR §180.2030(e)(11)

830.7050
UV/Visible light absorption 
Neutral sample
pH=2
pH=12
                                       A
ε (L/cm·mol)
26.0
27.4
25.8
44857701
830.7200
Melting point/melting range
                                       A
11-14°C
RED
830.7220
Boiling point/boiling range
                                       A
233-234°C
RED
830.7300
Density (20°C)
                                       A
0.827 g/mL
RED
830.7520
Particle size, fiber length, and diameter distribution
                                      N/A
See 40 CFR §180.2030(e)(15) or 
OCSPP 830.7520(a)(3)(i)

830.7550
830.7560
830.7570
Partition coefficient (n-Octanol/Water)
                                       A
Koc = 16,601
RED
830.7840
Water solubility 
                                       A
Insoluble

18.0x10[-3] g/L
Merck Index
RED
830.7950
Vapor pressure (20°C)
                                       A
4.49x10[-2] Torr
RED
   1. A=Acceptable. N/A=Not Applicable. N/D=Not Determined.



                                       
                                       
                                       
                                       
                                  References


Merck Index, Online. 02/07/12



