	UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

 		WASHINGTON, D.C. 20460

July 27, 2011

OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION

MEMORANDUM

SUBJECT:	Product Chemistry Scoping Document for the Registration Review
of Aminoethoxyvinylglycine Hydrochloride.  

Registration Review Case #:		6070

PC Code:						129104  

CAS Numbers:					55720-26-8

Chemical Class:					Biochemical

FROM:		Jacob Moore, Chemist /s/ 07/27/2011

Biochemical Pesticides Branch

Biopesticides & Pollution Prevention Division (7511P)

TO:			John Fournier, Regulatory Action Leader

Biochemical Pesticides Branch

Biopesticides & Pollution Prevention Division (7511P) 

ACTION REQUESTED

	A preliminary assessment of available information on product chemistry
data associated with the biopesticide aminoethoxyvinylglycine
hydrochloride in support of the development of a Registration Review
Work Plan.

Introduction

The EPA has made the determination that there is adequate information
available on aminoethoxyvinylglycine hydrochloride, commonly known as
AVG, and does not foresee the need to require additional data from
products currently registered that contain AVG as the active ingredient.
 AVG is a plant growth regulator used on apples, pears, and ornamentals.
In apples, it may delay fruit maturity, leading to benefits such as a
reduction in pre-harvest fruit drop and improved fruit quality. In
pears, AVG may help maintain fruit firmness. For specific ornamentals
(miniature carnations, hibiscus, and rooted geranium cuttings and
seedlings), AVG may reduce problems, such as flower senescence and
flower bud abscission, that occur during shipping. AVG products have
been registered with the EPA since 1997.  Currently there are 11 active
registrations containing AVG, including two technical grade active
ingredient registrations, six end-use or manufacturing-use products, and
three experimental use permits. The technical registrations contain 86%
active ingredient by weight with the balance consisting of impurities.
The Agency exempts AVG from the requirement of a tolerance under the
following conditions:

Commodity	Parts Per Million

Apple	0.08

Fruit, stone, group 12, except cherry	0.170

Pear	0.08

40 CFR §180.502

Concerning the product chemistry of AVG, all biochemical pesticide data
requirements for the technical grade active ingredient have been
satisfied and are summarized in Table 2.  While no further product
chemistry data are necessary for the products currently registered,
future products must adequately address all of the biochemical
pesticides product chemistry data requirements.



Table 1. Product Identity and Composition for AVG







Product Chemistry Summary

The Agency has conducted a review of the available product chemistry
data and information.  These data are summarized below.

Table 2. Biochemical Pesticides Product Chemistry Data Requirements for
AVG

Guideline No.	Physical and Chemical Properties	Status1	Value

830.1100	Product Identity and Composition	A	Refer to Table 1.

830.1200	Description of starting materials, production and formulation
process	A	CBI

830.1400	Discussion of formation of impurities	A	CBI

830.1700	Preliminary analysis	A	CBI

830.6302	Color	A	Light Brown

830.6303	Physical state	A	Powder

830.6304	Odor	A	Slightly musty

830.6313	Stability to normal and elevated temperatures, metals and metal
ions	N/D	Stable

830.7000	pH	A	6.9 (0.1% solution)

830.7050	UV/Visible light absorption

     Water ,303.0

     1N HCl/water (10/90) , 300.9

ε)

41.4 ± 0.5 L mol-1 cm-1

40.2 ± 0.2 L mol-1 cm-1

39.8 ± 2.2 L mol-1 cm-1

830.7200	Melting point/melting range	A	193-195°C

830.7220	Boiling point/boiling range	N/A	--

830.7300	Density	A	0.42 g/cm3

830.7520	Particle size, fiber length, and diameter distribution	N/A	N/A;
water soluble

830.7550

830.7560

830.7570	Partition coefficient (n-Octanol/Water)	A	Log Pow = -4.36±0.58

830.7840	Water solubility 	A	H2O pH 5.0 = 660 ± 39 g/L

H2O pH 6.0 = 674 ± 23 g/L

H2O pH 9.0 = 689 ± 10 g/L

830.7950	Vapor
pressure䄇嘇牥⁹潬㭷琠灹捩污猠汯摩܇㵁捁散瑰扡敬‮
⽎㵁潎⁴灁汰捩扡敬മ഍刍晥牥湥散൳

Ø	@

6

7

x

y

z

{

|

}

€

h¦

h¦

Ø	@

y

z

{

|

}

~



€

‚

ƒ

„

‘

Ø	@

Ø	@

 €

‚

„

‘

ä

h

h

h

Ø	@

将

将

将

将

将

将

将

将

将

将

将

将

将

将

将

将

将

将

将

将

将

将

将

将

将

将

将

将

将

将

将

将

将

将

Devisetty, B., Bade, T. Product Identity, Manufacturing Process,
VBC-30102 (AVG HCL Liquid Formulation). Private Study by Valent
Biosciences Corp Submitted to EPA. MRID 477707-01. 2009.

Merck Index, Online. 07/19/2011.

PubChem.
http://pubchem.ncbi.nlm.nih.gov/summary/summary.chi?cid=6434508.
07/25/2011.

Aminoethoxyvinylglycine Hydrochloride			Case #:  6070

129104

Aminoethoxyvinylglycine Hydrochloride			Case #:  6070

129104

Product Chemistry—Registration Review

  PAGE   \* MERGEFORMAT  5 

