                    UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
                               WASHINGTON, D.C.  20460
                                       
	
		OFFICE OF
	CHEMICAL SAFETY AND
	POLLUTION PREVENTION


MEMORANDUM

Date:  			21-MAY-2012

            Subject:		Fludioxonil.  Acute and Chronic Aggregate Dietary (Food and Drinking Water) Exposure and Risk Assessment for Uses on Ginseng, Leafy Petioles Crop Subgroup 4B, Pineapple (post-harvest treatment), Tuberous and Corm Vegetable Subgroup 1C, Tropical Fruit (post-harvest treatment), Bulb Onion Subgroup 3-07A, Green Onion subgroup 3-07B, Caneberry Subgroup 13-07A, Bushberry Subgroup 13-07B, Small Fruit Vine Climbing Subgroup 13-07F (except fuzzy kiwifruit), Low-Growing Berry Subgroup 13-07G (except cranberry), Fruiting Vegetable Group 8-10 (except tomato), Citrus Fruit Group 10-10, Pome Fruit Group 11-10, Leafy Vegetable (except Brassica) Subgroup 4A, Dragon Fruit, and Tomato (post-harvest treatment).  

PC Code:  071503
DP Barcode:  D389981
Decision Nos.:  447549, 448805
Registration Nos.:  100-953, 100-1242, 100-969, 100-1308
Petition Nos.:  1E7853, 1E7870
Regulatory Action:  Section 3 Registration
Risk Assessment Type:  Dietary
Case No.:  7017
TXR No.:  NA
CAS No.:  131341-86-1
MRID No.:  None
40 CFR:  §180.516

REVIEWER:	George F. Kramer, Ph.D., Senior Chemist
		Risk Assessment Branch 1 (RAB1)
		Health Effects Division (HED, 7509P)

THROUGH:	Mohsen Sahafeyan, Chemist
      Julie Van Alstine, MPH, Environmental Health Scientist
		Dietary Exposure Science Advisory Council (DESAC)
		and
		David E. Hrdy, Acting Branch Chief
		RAB1/HED (7509P)

TO:		Barbara Madden/Laura Nollen, RM 05
         		Mary Waller/Lisa Jones, RM 21
		Registration Division (RD, 7505P)

Executive Summary

Acute and chronic dietary (food plus water) exposure and risk assessments were conducted using the Dietary Exposure Evaluation Model (DEEM-FCID[(TM)], Version 2.03) which uses food consumption data from the U.S. Department of Agriculture's (USDA's) Continuing Surveys of Food Intakes by Individuals (CSFII) from 1994-1996 and 1998.  These analyses were performed to support the proposed Section 3 uses of fludioxonil on ginseng, leaf petioles, pineapple (post-harvest treatment), potato (post-harvest treatment), spinach, tropical fruit (post-harvest treatment), bulb onion, green onion, caneberry, bushberry, small fruit vine climbing (except fuzzy kiwifruit), low-growing berry (except cranberry), fruiting vegetables, citrus fruit, pome fruit, leafy vegetables (except Brassica), dragon fruit, and tomato (post-harvest treatment).

Acute Dietary (Food and Drinking Water) Exposure Results and Characterization 

An unrefined acute dietary exposure and risk analysis was performed assuming tolerance-level residues, 100% crop-treated (CT), and DEEM[(TM)] (ver. 7.81) default processing factors.  The 1-in-10-year acute drinking water estimate (i.e., relevant to acute exposure) of 0.0838 ppm, previously provided by Environmental Fate and Effects Division (EFED), was directly incorporated into the acute assessment.  This analysis was performed for the population subgroup females 13 to 49 years old; the only subgroup of interest for acute exposure.  The acute dietary (food plus water) risk utilizes 16% of acute population-adjusted dose (aPAD) for females 13 to 49 years old.

Chronic Dietary (Food and Drinking Water) Exposure Results and Characterization

A partially refined chronic dietary exposure and risk assessment was performed assuming tolerance-level residues for most commodities [with the exception of celery, pineapple, potato, spinach, apple, grapefruit, lemon, lime, orange, pear, tomato, head lettuce, leaf lettuce, fresh parsley, Brassica leafy vegetables (crop group 5), grape, cherry, peach and plum], 100% CT estimates, and DEEM[(TM)] (ver. 7.81) default processing factors [with the exception of citrus fruit juices (1X), apple juice (1X), grape juice (0.42X), raisin (1.65X), potato commodities (1X), and tomato commodities (1X), except dried tomato (14.3X)].  These processing factors are based upon processing study data.  Anticipated residue estimates (ARs) for celery, pineapple, potato, spinach, apple, grapefruit, lemon, lime, orange, pear, tomato, head lettuce, leaf lettuce, fresh parsley, Brassica leafy vegetables (crop group 5), grape, cherry, peach, and plum were generated from field trial and processing study data.  The 1-in-10-year chronic drinking water estimate (i.e., relevant to chronic exposure) of 0.0385 ppm, provided by the EFED, was directly incorporated into the chronic assessment.  For the U.S. population the dietary risk (food plus water) utilizes 26% of the chronic PAD (cPAD).  The chronic dietary risk estimate for the highest reported exposed population subgroup, children 1 to 2 years old, utilizes 68% of the cPAD.  

Cancer Dietary (Food and Drinking Water) Exposure Results and Characterization

Fludioxonil is classified as a Group D chemical - not classifiable as to human carcinogenicity; therefore, a cancer dietary exposure and risk assessment was not performed for fludioxonil. 


I.  Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide.  For acute and chronic assessments, the risks are expressed as a percentage of a maximum acceptable dose.  This is the PAD, which HED has concluded will result in no unreasonable adverse health effects. The PAD is equivalent to the point of departure (POD; e.g., NOAEL, LOAEL) divided by the required uncertainty or safety factors.  Dietary risk is expressed as a percentage of the PAD.
For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD.  References which discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site:  "Available Information on Assessing Exposure from Pesticides, A User's Guide", 21/06/2000, web link:  http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf; or see SOP 99.6 (08/20/1999).

The most recent dietary risk assessment for fludioxonil was conducted by D. Rate (DP#379936, 07/14/2010).


II.  Residue Information

Established Tolerances:  Permanent tolerances for residues of fludioxonil are listed in 40 CFR §180.516 and are expressed in terms of fludioxonil (4-(2, 2-difluoro-1, 3-benzodioxol-4-yl)-1H - pyrrole-3-carbonitrile) in/on a variety of plant commodities. 

Residue of Concern:  The HED Metabolism Assessment Review Committee (MARC) has determined that the residue of concern for purposes of tolerance enforcement and risk assessment, is the parent fludioxonil (DP#262022, W. Donovan et al., 01/18/2000).  As part of a previous tolerance petition memo, an additional reviewed plant metabolism study reconfirmed fludioxonil as the only residue of concern (DP#287808, T. Bloem, 02/12/2003).  The nature of the residues in livestock is also understood based on the adequate goat and hen metabolism studies.  For purposes of tolerance enforcement and risk assessment, the residues of concern in ruminants are fludioxonil and Metabolite B-1, and the residues of concern in poultry are fludioxonil, CGA-344623, and Metabolite I-1.

Recommended Tolerances:  As part of the current petition, HED recommends establishing the following tolerances: 

CFR §180.516 (a) General. (1) should be as follows: "Tolerances are established for residues of the fungicide fludioxonil, including its metabolites and degradates, in or on the commodities in the table below.  Compliance with the tolerance levels specified below is to be determined by measuring only fludioxonil, 4-(2,2-difluoro-1,3-benzodioxol-4-yl)-1-H-pyrrole-3-carbonitrile)."

Guava
5.0 ppm
Feijoa
5.0 ppm
Jaboticaba
5.0 ppm
Wax jambu
5.0 ppm
Starfruit
5.0 ppm
Passionfruit
5.0 ppm 
Acerola
5.0 ppm
Avocado
5.0 ppm
Black sapote
5.0 ppm
Mamey sapote
5.0 ppm
Canistel
5.0 ppm
Mango
5.0 ppm
Papaya
5.0 ppm
Sapodilla
5.0 ppm
Star apple
5.0 ppm
Lychee
20 ppm
Longan
20 ppm
Spanish lime
20 ppm
Rambutan
20 ppm
Pulasan
20 ppm
Sugar apple
20 ppm
Atemoya
20 ppm
Custard apple
20 ppm
Cherimoya
20 ppm
Ilama
20 ppm
Soursop
20 ppm
Biriba
20 ppm
Ginseng
4.0 ppm
Onion, bulb subgroup 3-07A
0.50 ppm
Onion, green subgroup 3-07B
7.0 ppm
Caneberry subgroup 13-07A
5.0 ppm 
Bushberry subgroup 13-07B
2.0 ppm
Fruit, small, vine climbing, subgroup 13-07F, except fuzzy kiwifruit
2.0 ppm
Low growing berry subgroup 13-07G, except cranberry
3.0 ppm
Vegetable, fruiting group 8-10, except tomato
0.50 ppm
Tomato
5.0 ppm
Fruit, citrus, group 10-10
10 ppm
Fruit, pome, group 11-10
5.0 ppm
Vegetable, Leafy, except Brassica, subgroup 4A
30 ppm
Vegetable, tuberous and corm, subgroup 1C
6.0 ppm
Pineapple
20 ppm
Dragon fruit
1.0 ppm
Leafy petioles crop subgroup 4B
15 ppm

The residue definition for the tolerance expression for CFR §180.516 (a) General. (2) should be as follows: "Tolerances are established for residues of the fungicide fludioxonil, including its metabolites and degradates, in or on the commodities in the table below.  Compliance with the tolerance levels specified below is to be determined by measuring only the sum of fludioxonil, 4-(2,2-difluoro-1,3-benzodioxol-4-yl)-1-H-pyrrole-3-carbonitrile), and its metabolites converted to 2,2-difluoro-l,3-benzodioxole-4-carboxylic acid, calculated as the stoichiometric equivalent of fludioxonil."
Milk
0.01 ppm
Cattle, meat byproducts
0.05 ppm
Cattle, meat 
0.01 ppm
Cattle, fat 
0.05 ppm
Goat, meat byproducts
0.05 ppm
Goat, meat 
0.01 ppm
Goat, fat 
0.05 ppm
Horse, meat byproducts
0.05 ppm
Horse, meat 
0.01 ppm
Horse, fat 
0.05 ppm
Sheep, meat byproducts
0.05 ppm
Sheep, meat 
0.01 ppm
Sheep, fat 
0.05 ppm

No new data were submitted to support tolerances on onion, bulb, subgroup 3-07A; onion, green, subgroup 3-07B; low-growing berry 13-07G crop subgroup; caneberry subgroup 13A; bushberry subgroup 13B; fruit, citrus, group 10; fruit, pome, group 11-10; or small fruit vine climbing subgroup 13-07F, except fuzzy kiwifruit.  The petitioner has requested that existing tolerances be expanded to their respective crop groups or crop subgroups.
Residue Data Used for Acute and Chronic Assessments:  

Established and recommended tolerance-level residues, 100% CT, and DEEM[(TM)] (ver. 7.81) default processing factors were utilized for the acute assessment.  

The chronic assessment was based on the assumption of tolerance-level residues for most commodities and 100% CT.  ARs for apple, grapefruit, lemon, lime, orange, pear, head lettuce (with wrapper), leaf lettuce, fresh parsley, Brassica leafy vegetables (crop group 5), grape, cherry, peach, and plum were previously generated from field trial data (D. Rate, DP#379936, 07/14/2010).  ARs for tomato, celery, pineapple, potato, and spinach were also generated from field trial data for this assessment, see Table 1, below.  For Brassica leafy vegetables (crop group 5), the field trial data were translated from the representative commodities in the crop groups to the non-representative commodities according to HED SOP 2000.1:  "Guidance for Translation of Field Trial Data from Representative Commodities in the Crop Group Regulation to Other Commodities in Each Crop Group/Subgroup."  ARs were determined for apple, grapefruit, lemon, and lime juices (J. Sullivan and M. Papathakis, 02/27/2004) using average residues from field trials and processing studies.  As a result, processing factors were set to 1X for these juices.  The value for orange juice was set to 0.0 ppm as fungicide-treated fruit are not processed and Pesticide Data Program (PDP) monitoring data reported no detectable residues in orange juice (16th Annual Summary, data from calendar year 2006).  The submitted grape processing study indicated that fludioxonil residues do not concentrate in juice or appreciably in raisin.  The processing factors were set to 0.42X for grape juice and 1.65X for raisin.  The submitted tomato, pineapple, and potato processing study indicated that fludioxonil residues do not appreciably concentrate in processed commodities made from treated tomato, pineapple, and potato samples; therefore, separate tolerances are not required for tomato, pineapple, and potato processed commodities.  Processing factors were set to 1X for these processed commodities (pineapple juice; tomato paste, juice, and puree; and potato chips, flakes, and flour).  DEEM[(TM)] (ver. 7.81) default processing factors were used for all other processed commodities for which they are available.

Table 1.  AR Values Used for the Chronic Assessment.
Commodity
                                  AR (ppm)[2]
Apple, whole
            juice
                                      1.1
                                      0.1
Grapefruit, whole
                   juice
                                      2.6
                                     0.74
Lemon, whole
              juice
                                      1.7
                                     0.02
Lime, whole
           juice
                                      1.7
                                     0.02
Orange[1], whole
               juice
                                      1.5
                                      0.0
Pear, whole         
                                      1.6
Tomato 
                                     0.89
Lettuce, head (with wrapper leaves)
                                     2.09
Lettuce, leaf
                                     10.77
Parsley, fresh
                                     1.23
Brassica leafy vegetables (crop group 5)
       Cabbage
       Mustard greens
       Broccoli
                                       
                                       
                                     0.34
                                     1.03
                                     0.13
Grape
                                     0.33
Cherry 
                                     0.82
Peach
                                     0.40
Plum
                                     0.51
Celery
                                      4.9
Pineapple
                                     5.64
Potato
                                     1.82
Spinach
                                      7.1
	      [1] Also represents tangerine.
            [2] ARs calculated for the current memo were taken from field trial data associated with the following
              MRID Nos.:  48478501, 48437302, 48437101, 48437305, and 48438204.


III.  Drinking Water Data

Estimated drinking water concentrations (EDWCs) were generated using EFED's standard suite of models (DP#389616, C. Sutton, 10/27/2011).  The Pesticide Root Zone Model (PRZM, v3.12.2, May 2005) and Exposure Analysis Modeling System (EXAMS, v2.98.4.6, April 2005) are simulation models used to generate EDWCs of fludioxonil residues that may occur in surface water used as drinking water.  The PRZM model simulates pesticide movement and transformation on and across the agricultural field resulting from crop applications.  Percent-cropped areas (PCA) that account for the maximum area within a watershed that may be planted with the modeled crop are applied to concentrations predicted by PRZM/EXAMS.  The models and their descriptions are available at the EPA internet site: http://www.epa.gov/oppefed1/models/water/.  

Screening Concentration in Ground Water (SCI-GROW v2.3, Jul. 29, 2003) is a regression model used as a screening tool to estimate pesticide concentrations found in groundwater used as drinking water.  The output of SCI-GROW represents the concentrations of fludioxonil that might be expected in shallow unconfined aquifers under sandy soils, which is representative of the groundwater most vulnerable to pesticide contamination and likely to serve as a drinking water source.  

The maximum proposed application rate among all new proposed uses (for onion subgroups 3-07A and 3-07A) is 0.25 lbs ai/A/application, applied four times per year with a 7-day application interval, for a maximum total annual application rate of 1.0 lb ai/A/yr.  Because the maximum proposed application rate among all of the uses considered for this assessment is less than the rates previously assessed by EFED for ornamentals, the EDWCs based on use on ornamentals are recommended for use in the human-health dietary assessment.  However, based on information provided in Syngenta's 9/9/2011 submission "Fludioxonil Registration Review Public Comments Response to Initial 60-Day Comment Period, Case Number: 7017, Docket Number: EPA-HQ-OPP-2010-1067," EFED concurs that the use of the container-grown ornamentals application rate is not appropriate for estimating EDWCs.  As noted by the registrant, the strong adsorption of the pesticide to the potting media used for container-grown ornamentals, as well as the use of containers, results in attenuation of pesticide movement from the containers to the underlying soil in the field, thereby reducing potential runoff of the pesticide.  Thus, EFED now recommends that the values from the Tier I DWA of 6/22/2009 (D364264) be used in HED's human dietary health assessment.  The values in the Tier I DWA are based on the use of fludioxonil on field-grown ornamentals at one application of 2 lb ai/A/yr.  The resulting acute and chronic EDWCs in surface water were 83.8 ppb (1-in-10-year acute estimate) and 38.5 ppb (1-in-10-year chronic estimate), respectively.  The EDWC for groundwater (for both acute and chronic analysis) is 0.2 ppb.  Since the surface water concentrations were the highest; the acute and chronic dietary runs were conducted assuming water residues of 0.0838 ppm and 0.0385 ppm, respectively, for all water sources (direct and indirect). 

Table 2.  Tier II Estimated Drinking Water Concentrations (EDWCs) Resulting From Applications of Fludioxonil on Ornamentals (Total Rate of 4 lb ai/A/yr).
Drinking water source (model)
                                       
                                      Use
                          1-in-10-year acute (ug/L)
                         1-in-10-year chronic (ug/L)
Surface water (PRZM/EXAMS)
Container-grown ornamental
                                     83.8
                                     38.5
Groundwater (SCI-GROW)
Container-grown ornamental
                                      0.2
                                      0.2


IV.  DEEM-FCID(TM) Program and Consumption Information

Fludioxonil acute and chronic dietary exposure assessments were conducted using the DEEM-FCID[(TM)] model, Version 2.03, which incorporates consumption data from USDA's CSFII, 1994-1996 and 1998.  The 1994-96, 98 data are based on the reported consumption of more than 20,000 individuals over two non-consecutive survey days.  Foods "as consumed" (e.g., apple pie) are linked to EPA-defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA.  For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups, but for acute exposure assessment are retained as individual consumption events.  Based on analysis of the 1994-96, 98 CSFII consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or food-form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food form to produce a residue intake estimate.  The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure.  Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD.  This procedure is performed for each population subgroup.

For acute exposure assessments, individual one-day food consumption data are used on an individual-by-individual basis.  The reported consumption amounts of each food item can be multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or "matched" in multiple random pairings with residue values and then summed in a probabilistic assessment.  The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating relevant commodities/food forms) and a per-capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis.  In accordance with HED policy, per capita exposure and risk are reported for all tiers of analysis.  However, for Tiers 1 and 2, any significant differences in user vs. per capita exposure and risk are specifically identified and noted in the risk assessment.


V.  Toxicological Information

The HED Hazard Identification Assessment Review Committee (HIARC) previously reviewed the fludioxonil toxicological database (HED Doc. No. 013806, W. Dykstra, 10/13/1999; TXR No. 0050427, W. Dykstra, 01/29/2002) and concluded that the 10X safety factor should be reduced to 1X.  The most recent review of the toxicology database (DP#389613, G. Kramer et al., 05/21/2012) showed that the database is essentially complete and there is no evidence of neurotoxicity or immunotoxicity in the hazard database for fludioxonil.  While the new Part 158 requirements for an immunotoxicity study and acute and subchronic neurotoxicity studies have not yet been fulfilled for fludioxonil, the existing data are sufficient for endpoint selection for exposure/risk assessment scenarios and for evaluation of the requirements under the Food Quality Protection Act (FQPA).  The toxicological endpoints used for dietary exposure for fludioxonil are summarized in Table 3, below.  

Table 3.  Summary of Toxicological Doses and Endpoints for Fludioxonil for Use in Dietary Exposure Risk Assessments.
Exposure/
Scenario
Point of Departure 
Uncertainty/FQPA Safety Factors
RfD, PAD 
Study and Toxicological Effects
Acute Dietary (General Population, including Infants and Children)
There were no appropriate toxicological effects attributable to a single exposure (dose) observed in available oral toxicity studies, including maternal toxicity in the developmental toxicity studies.  Therefore, a dose and endpoint were not identified for this risk assessment.
Acute Dietary
(Females 13-49 years of age)
NOAEL = 100 mg/kg/day
UFA = 10X
UFH = 10X
FQPA SF = 1X
Acute RfD = 1.0 mg/kg/day

aPAD = 1.0 mg/kg/day
Rat developmental study.  LOAEL = 1000 mg/kg/day based on an increased incidence of fetuses and litters with dilated renal pelvis and dilated ureter in rat developmental study.
Chronic Dietary (All Populations)
NOAEL= 3.3 mg/kg/day
UFA = 10X
UFH = 10X
FQPA SF = 1X
Chronic RfD = 0.033 mg/kg/day

cPAD = 0.033 mg/kg/day
One-year dog feeding study.  LOAEL = 35.5 mg/kg/day based on based on decreased weight gain in female dogs during weeks 1-52.
Cancer (oral, dermal, inhalation)   
Classification:  HED's Cancer Peer Review Committee has classified fludioxonil as a Group D chemical - not classifiable as to human carcinogenicity.  
Point of departure (POD) = A data point or an estimated point that is derived from observed dose-response data and  used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures.  NOAEL = no-observed adverse-effect level.  LOAEL = lowest-observed adverse-effect level.  UF = uncertainty factor.  UFA = extrapolation from animal to human (intraspecies).  UFH = potential variation in sensitivity among members of the human population (interspecies).  FQPA SF = FQPA Safety Factor.  PAD = population-adjusted dose (a = acute, c = chronic).  RfD = reference dose.  N/A = not applicable.


VI.  Results/Discussion

For acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the PAD.  The DEEM-FCID[(TM)] analyses estimate the dietary exposure of the U.S. population and various population subgroups.  The results reported in the Summary Table (Table 4) are for the general U.S. population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, females 13-49, adults 20-49, and adults 50+ years.  

Results of Acute and Chronic Dietary Exposure Analyses

The acute dietary risk for fludioxonil at the 95[th] percentile of exposure (food plus water) utilizes 16% of the aPAD for females 13 to 49 years old.  There were no appropriate toxicological effects attributable to a single exposure (dose) for the general population or any other population subgroups; therefore, these population subgroups were not included in this assessment.

The chronic dietary risk for the U.S. population (food plus water) for fludioxonil utilizes 26% of the cPAD.  The chronic dietary risk for the highest exposed population subgroup, children 1-2 years old, is 68% of the cPAD.

The results of the acute and chronic dietary exposure and risk analyses are reported in the Summary Table (Table 4, below).  

Table 4.  Summary of Dietary Exposure (Food Plus Water) and Risk Assessment for Fludioxonil.
Population Subgroup
                                 Acute Dietary
                               (95th Percentile)
                                Chronic Dietary

                         Dietary Exposure (mg/kg/day)
                                    % aPAD*
                               Dietary Exposure
                                  (mg/kg/day)
                                    % cPAD*
General U.S. Population
                                      N/A
                                   0.008711
                                      26
All Infants (<1 year old)
                                       
                                   0.018891
                                      57
Children 1-2 years old
                                       
                                   0.022497
                                      68
Children 3-5 years old
                                       
                                   0.017817
                                      54
Children 6-12 years old
                                       
                                   0.011011
                                      33
Youth 13-19 years old
                                       
                                   0.006547
                                      20
Adults 20-49 years old
                                       
                                   0.006943
                                      21
Adults 50+ years old
                                       
                                   0.007778
                                      24
Females 13-49 years old
                                   0.164096
                                      16
                                   0.007073
                                      21
 * % PADs are reported to 2 significant figures.  The values for the highest exposed population for each type of risk assessment are bolded.


VII.  Characterization of Inputs/Outputs

These analyses are conservative dietary exposure assessments.  Further refinement to the analyses could be made through the use of additional ARs, incorporation of percent CT estimates, and/or monitoring data that better reflect residues at the time of consumption.  

The acute dietary exposure and risk assessment incorporated tolerance-level residues (established and recommended), 100% CT, and DEEM[(TM)] (ver. 7.81) default processing factors.  The 1-in-10-year acute drinking water estimate (i.e., relevant to acute exposure) of 0.0838 ppm was directly incorporated into the acute assessment.  
A partially refined chronic dietary exposure and risk assessment was performed assuming tolerance-level residues for most commodities [with the exception of celery, pineapple, potato, spinach, apple, grapefruit, lemon, lime, orange, pear, tomato, head lettuce, leaf lettuce, fresh parsley, Brassica leafy vegetables (crop group 5), grape, cherry, peach and plum], 100% CT estimates, and DEEM[(TM)] (ver. 7.81) default processing factors [with the exception of citrus fruit juice (1X), apple juice (1X), grape juice (0.42X), raisin (1.65X), potato commodities (1X), and tomato commodities (1X), except dried tomato (14.3X)].  These processing factors are based upon processing study data.  ARs for celery, pineapple, potato, spinach, apple, grapefruit, lemon, lime, orange, pear, tomato, head lettuce, leaf lettuce, fresh parsley, Brassica leafy vegetables (crop group 5), grape, cherry, peach, and plum were generated from field trial and processing study data for the chronic analysis.  The 1-in-10-year chronic drinking water estimate (i.e., relevant to chronic exposure) of 0.0385 ppm, provided by the EFED, was directly incorporated into the chronic assessment.

HED concludes that the exposure estimates provided in this document are unlikely to underestimate actual exposure for the following reasons:  (1) the analysis incorporated tolerance-level residues or made use of average residues derived from crop field trial studies (maximum application rate and minimum pre-harvest interval); and (2) the surface drinking water estimates were from a conservative drinking water assessment and are based upon the maximum use rate pattern on the label.  


VIII.  Conclusions

Acute and chronic dietary (food plus drinking water) dietary exposure and risk assessment assessments were conducted for fludioxonil to support the proposed Section 3 uses of fludioxonil on ginseng, leaf petioles, pineapple (post-harvest treatment), potato (post-harvest treatment), spinach, tropical fruit (post-harvest treatment), bulb onion, green onion, caneberry, bushberry, small fruit vine climbing (except fuzzy kiwifruit), low-growing berry (except cranberry), fruiting vegetables, citrus fruit, pome fruit, leafy vegetables (except Brassica), dragon fruit, and tomato (post-harvest treatment).  The acute dietary (food plus drinking water) exposure to fludioxonil is below HED's level of concern for females 13 to 49 years old (the only subgroup of interest).  The acute dietary risk utilizes 16% of the aPAD at the 95[th] percentile for females 13-49 years old.  The chronic dietary (food plus drinking water) exposure to fludioxonil is below HED's level of concern for the general U.S. population and all population subgroups.  The chronic dietary risk utilizes 26% of the cPAD for the general U.S. population; and, for the most highly exposed population subgroup (children 1-2 years old) 68% of the cPAD. 


IX.  List of Attachments

Attachment 1:	DEEM-FCID[(TM)] Acute Residue File
Attachment 2:	DEEM-FCID[(TM)] Acute Exposure and Risk Estimates
Attachment 3:	DEEM-FCID[(TM)] Chronic Residue File
Attachment 4:	DEEM-FCID[(TM)] Chronic Exposure and Risk Estimates



cc:  G. Kramer
G.F. Kramer:S10957:PY-S:(703)305-5079:7509P:RAB1
Attachment 1:	DEEM-FCID[(TM)] Acute Residue File
Filename: C:\Documents and Settings\gkramer\My Documents\Gk\##Fludioxonil\2012_071503a.R98
Chemical: Fludioxonil
RfD(Chronic): .03 mg/kg bw/day  NOEL(Chronic): 3.3 mg/kg bw/day
RfD(Acute): 1 mg/kg bw/day  NOEL(Acute):  100 mg/kg bw/day
Date created/last modified: 05-17-2012/13:28:47/8          Program ver. 2.03
Comment: DPR Work-share Acute/Chronic Dietary with new FY04 Section 3 Tolerances
--------------------------------------------------------------------------------
  EPA    Crop                                   Def Res     Adj.Factors   Comment
  Code    Grp  Commodity Name                    (ppm)       #1    #2   
-------- ---- -------------------------------  ----------  ------ ------  -------
01010500 1AB  Beet, garden, roots                0.750000   1.000  1.000   
01010501 1AB  Beet, garden, roots-babyfood       0.750000   1.000  1.000   
01010520 1A   Beet, sugar                        0.020000   1.000  1.000  
01010521 1A   Beet, sugar-babyfood               0.020000   1.000  1.000  
01010530 1A   Beet, sugar, molasses              0.020000   1.000  1.000  
01010531 1A   Beet, sugar, molasses-babyfood     0.020000   1.000  1.000  
01010670 1AB  Burdock                            0.750000   1.000  1.000   
01010780 1AB  Carrot                             0.750000   1.000  1.000   
01010781 1AB  Carrot-babyfood                    0.750000   1.000  1.000   
01010790 1AB  Carrot, juice                      0.750000   1.000  1.000   
01010840 1AB  Celeriac                           0.750000   1.000  1.000   
01011000 1AB  Chicory, roots                     0.750000   1.000  1.000   
01011680 1AB  Ginseng, dried                     4.000000   1.000  1.000   
01011900 1AB  Horseradish                        0.750000   1.000  1.000   
01012500 1AB  Parsley, turnip rooted             0.750000   1.000  1.000   
01012510 1AB  Parsnip                            0.750000   1.000  1.000   
01012511 1AB  Parsnip-babyfood                   0.750000   1.000  1.000   
01013140 1AB  Radish, roots                      0.750000   1.000  1.000   
01013160 1AB  Radish, Oriental, roots            0.750000   1.000  1.000   
01013270 1AB  Rutabaga                           0.750000   1.000  1.000   
01013310 1AB  Salsify, roots                     0.750000   1.000  1.000   
01013880 1AB  Turnip, roots                      0.750000   1.000  1.000   
01030150 1CD  Arrowroot, flour                   6.000000   1.000  1.000  
01030151 1CD  Arrowroot, flour-babyfood          6.000000   1.000  1.000  
01030170 1CD  Artichoke, Jerusalem               6.000000   1.000  1.000  
01030820 1CD  Cassava                            6.000000   1.000  1.000  
01030821 1CD  Cassava-babyfood                   6.000000   1.000  1.000  
01031390 1CD  Dasheen, corm                      6.000000   1.000  1.000  
01031660 1CD  Ginger                             6.000000   1.000  1.000  
01031661 1CD  Ginger-babyfood                    6.000000   1.000  1.000  
01031670 1CD  Ginger, dried                      6.000000   1.000  1.000  
01032960 1C   Potato, chips                      6.000000   1.000  1.000  
01032970 1C   Potato, dry (granules/ flakes)     6.000000   6.500  1.000  
01032971 1C   Potato, dry (granules/ flakes)-b   6.000000   6.500  1.000  
01032980 1C   Potato, flour                      6.000000   6.500  1.000  
01032981 1C   Potato, flour-babyfood             6.000000   6.500  1.000  
01032990 1C   Potato, tuber, w/peel              6.000000   1.000  1.000  
01032991 1C   Potato, tuber, w/peel-babyfood     6.000000   1.000  1.000  
01033000 1C   Potato, tuber, w/o peel            6.000000   1.000  1.000  
01033001 1C   Potato, tuber, w/o peel-babyfood   6.000000   1.000  1.000  
01033660 1CD  Sweet potato                       6.000000   1.000  1.000  
01033661 1CD  Sweet potato-babyfood              6.000000   1.000  1.000  
01033710 1CD  Tanier, corm                       6.000000   1.000  1.000  
01033870 1CD  Turmeric                           6.000000   1.000  1.000  
01034060 1CD  Yam, true                          8.000000   1.000  1.000  
01034070 1CD  Yam bean                           6.000000   1.000  1.000  
02000510 2    Beet, garden, tops                30.000000   1.000  1.000   
02001010 2    Chicory, tops                     30.000000   1.000  1.000   
02001400 2    Dasheen, leaves                   30.000000   1.000  1.000   
02003150 2    Radish, tops                      30.000000   1.000  1.000   
02003170 2    Radish, Oriental, tops            30.000000   1.000  1.000   
02003320 2    Salsify, tops                     30.000000   1.000  1.000   
03001640 3    Garlic                             0.500000   1.000  1.000  
03001650 3    Garlic, dried                      0.500000   1.000  1.000  
03001651 3    Garlic, dried-babyfood             0.500000   1.000  1.000  
03001980 3    Leek                               7.000000   1.000  1.000  
03002370 3    Onion, dry bulb                    0.500000   1.000  1.000  
03002371 3    Onion, dry bulb-babyfood           0.500000   1.000  1.000  
03002380 3    Onion, dry bulb, dried             0.500000   9.000  1.000  
03002381 3    Onion, dry bulb, dried-babyfood    0.500000   9.000  1.000  
03002390 3    Onion, green                       7.000000   1.000  1.000  
03003380 3    Shallot                            0.500000   1.000  1.000  
04010050 4A   Amaranth, leafy                   30.000000   1.000  1.000  
04010180 4A   Arugula                           30.000000   1.000  1.000  
04011040 4A   Chrysanthemum, garland            30.000000   1.000  1.000  
04011330 4A   Cress, garden                     30.000000   1.000  1.000  
04011340 4A   Cress, upland                     30.000000   1.000  1.000  
04011380 4A   Dandelion, leaves                 30.000000   1.000  1.000  
04011500 4A   Endive                            30.000000   1.000  1.000  
04012040 4A   Lettuce, head                     30.000000   1.000  1.000  
04012050 4A   Lettuce, leaf                     30.000000   1.000  1.000  
04012480 4A   Parsley, leaves                   30.000000   1.000  1.000  
04013130 4A   Radicchio                         30.000000   1.000  1.000  
04013550 4A   Spinach                           30.000000   1.000  1.000  
04013551 4A   Spinach-babyfood                  30.000000   1.000  1.000  
04020760 4B   Cardoon                           15.000000   1.000  1.000  
04020850 4B   Celery                            15.000000   1.000  1.000  
04020851 4B   Celery-babyfood                   15.000000   1.000  1.000  
04020860 4B   Celery, juice                     15.000000   1.000  1.000  
04020870 4B   Celtuce                           15.000000   1.000  1.000  
04021520 4B   Fennel, Florence                  15.000000   1.000  1.000  
04023220 4B   Rhubarb                           15.000000   1.000  1.000  
04023670 4B   Swiss chard                       15.000000   1.000  1.000  
05010610 5A   Broccoli                           2.000000   1.000  1.000  
05010611 5A   Broccoli-babyfood                  2.000000   1.000  1.000  
05010620 5A   Broccoli, Chinese                  2.000000   1.000  1.000  
05010640 5A   Brussels sprouts                   2.000000   1.000  1.000  
05010690 5A   Cabbage                            2.000000   1.000  1.000  
05010710 5A   Cabbage, Chinese, napa             2.000000   1.000  1.000  
05010720 5A   Cabbage, Chinese, mustard          2.000000   1.000  1.000  
05010830 5A   Cauliflower                        2.000000   1.000  1.000  
05011960 5A   Kohlrabi                           2.000000   1.000  1.000  
05020630 5B   Broccoli raab                     10.000000   1.000  1.000  
05020700 5B   Cabbage, Chinese, bok choy        10.000000   1.000  1.000  
05021170 5B   Collards                          10.000000   1.000  1.000  
05021940 5B   Kale                              10.000000   1.000  1.000  
05022290 5B   Mustard greens                    10.000000   1.000  1.000  
05023180 5B   Rape greens                       10.000000   1.000  1.000  
05023890 5B   Turnip, greens                    10.000000   1.000  1.000  
06003470 6    Soybean, seed                      0.010000   1.000  1.000  
06003480 6    Soybean, flour                     0.010000   1.000  1.000  
06003481 6    Soybean, flour-babyfood            0.010000   1.000  1.000  
06003490 6    Soybean, soy milk                  0.010000   1.000  1.000  
06003491 6    Soybean, soy milk-babyfood or in   0.010000   1.000  1.000  
06003500 6    Soybean, oil                       0.010000   1.000  1.000  
06003501 6    Soybean, oil-babyfood              0.010000   1.000  1.000  
06010430 6A   Bean, snap, succulent              0.400000   1.000  1.000  
06010431 6A   Bean, snap, succulent-babyfood     0.400000   1.000  1.000  
06012570 6A   Pea, edible podded, succulent      0.010000   1.000  1.000  
06020310 6B   Bean, broad, succulent             0.400000   1.000  1.000  
06020330 6B   Bean, cowpea, succulent            0.400000   1.000  1.000  
06020370 6B   Bean, lima, succulent              0.400000   1.000  1.000  
06022550 6B   Pea, succulent                     0.010000   1.000  1.000  
06022551 6B   Pea, succulent-babyfood            0.010000   1.000  1.000  
06022590 6B   Pea, pigeon, succulent             0.010000   1.000  1.000  
06030300 6C   Bean, black, seed                  0.400000   1.000  1.000  
06030320 6C   Bean, broad, seed                  0.400000   1.000  1.000  
06030340 6C   Bean, cowpea, seed                 0.400000   1.000  1.000  
06030350 6C   Bean,  great northern, seed        0.400000   1.000  1.000  
06030360 6C   Bean, kidney, seed                 0.400000   1.000  1.000  
06030380 6C   Bean, lima, seed                   0.400000   1.000  1.000  
06030390 6C   Bean, mung, seed                   0.400000   1.000  1.000  
06030400 6C   Bean, navy, seed                   0.400000   1.000  1.000  
06030410 6C   Bean, pink, seed                   0.400000   1.000  1.000  
06030420 6C   Bean, pinto, seed                  0.400000   1.000  1.000  
06030980 6C   Chickpea, seed                     0.400000   1.000  1.000  
06030981 6C   Chickpea, seed-babyfood            0.400000   1.000  1.000  
06030990 6C   Chickpea, flour                    0.400000   1.000  1.000  
06031820 6C   Guar, seed                         0.400000   1.000  1.000  
06031821 6C   Guar, seed-babyfood                0.400000   1.000  1.000  
06032030 6C   Lentil, seed                       0.400000   1.000  1.000  
06032560 6C   Pea, dry                           0.010000   1.000  1.000  
06032561 6C   Pea, dry-babyfood                  0.010000   1.000  1.000  
06032580 6C   Pea, pigeon, seed                  0.010000   1.000  1.000  
08001480 8    Eggplant                           0.500000   1.000  1.000  
08002340 8    Okra                               0.500000   1.000  1.000  
08002700 8    Pepper, bell                       0.500000   1.000  1.000  
08002701 8    Pepper, bell-babyfood              0.500000   1.000  1.000  
08002710 8    Pepper, bell, dried                0.500000   1.000  1.000  
08002711 8    Pepper, bell, dried-babyfood       0.500000   1.000  1.000  
08002720 8    Pepper, nonbell                    0.500000   1.000  1.000  
08002721 8    Pepper, nonbell-babyfood           0.500000   1.000  1.000  
08002730 8    Pepper, nonbell, dried             0.500000   1.000  1.000  
08003740 8    Tomatillo                          0.500000   1.000  1.000   
08003750 8    Tomato                             5.000000   1.000  1.000   
08003751 8    Tomato-babyfood                    5.000000   1.000  1.000   
08003760 8    Tomato, paste                      5.000000   5.400  1.000   
08003761 8    Tomato, paste-babyfood             5.000000   5.400  1.000   
08003770 8    Tomato, puree                      5.000000   3.300  1.000   
08003771 8    Tomato, puree-babyfood             5.000000   3.300  1.000   
08003780 8    Tomato, dried                      5.000000  14.300  1.000    
08003781 8    Tomato, dried-babyfood             5.000000  14.300  1.000   
08003790 8    Tomato, juice                      5.000000   1.500  1.000   
09010750 9A   Cantaloupe                         0.450000   1.000  1.000   
09010800 9A   Casaba                             0.450000   1.000  1.000   
09011870 9A   Honeydew melon                     0.450000   1.000  1.000   
09013990 9A   Watermelon                         0.450000   1.000  1.000   
09014000 9A   Watermelon, juice                  0.450000   1.000  1.000   
09020210 9B   Balsam pear                        0.450000   1.000  1.000   
09020880 9B   Chayote, fruit                     0.450000   1.000  1.000   
09021020 9B   Chinese waxgourd                   0.450000   1.000  1.000   
09021350 9B   Cucumber                           0.450000   1.000  1.000   
09023080 9B   Pumpkin                            0.450000   1.000  1.000   
09023090 9B   Pumpkin, seed                      0.450000   1.000  1.000   
09023560 9B   Squash, summer                     0.450000   1.000  1.000   
09023561 9B   Squash, summer-babyfood            0.450000   1.000  1.000   
09023570 9B   Squash, winter                     0.450000   1.000  1.000   
09023571 9B   Squash, winter-babyfood            0.450000   1.000  1.000   
10001060 10   Citrus citron                     10.000000   1.000  1.000  
10001070 10   Citrus hybrids                    10.000000   1.000  1.000  
10001080 10   Citrus, oil                      500.000000   1.000  1.000   
10001800 10   Grapefruit                        10.000000   1.000  1.000  
10001810 10   Grapefruit, juice                 10.000000   2.100  1.000  
10001970 10   Kumquat                           10.000000   1.000  1.000  
10001990 10   Lemon                             10.000000   1.000  1.000  
10002000 10   Lemon, juice                      10.000000   2.000  1.000  
10002001 10   Lemon, juice-babyfood             10.000000   2.000  1.000  
10002010 10   Lemon, peel                       10.000000   1.000  1.000  
10002060 10   Lime                              10.000000   1.000  1.000  
10002070 10   Lime, juice                       10.000000   2.000  1.000  
10002071 10   Lime, juice-babyfood              10.000000   2.000  1.000  
10002400 10   Orange                            10.000000   1.000  1.000  
10002410 10   Orange, juice                     10.000000   1.800  1.000  
10002411 10   Orange, juice-babyfood            10.000000   1.800  1.000  
10002420 10   Orange, peel                      10.000000   1.000  1.000  
10003070 10   Pummelo                           10.000000   1.000  1.000  
10003690 10   Tangerine                         10.000000   1.000  1.000  
10003700 10   Tangerine, juice                  10.000000   2.300  1.000  
11000070 11   Apple, fruit with peel             5.000000   1.000  1.000  
11000080 11   Apple, peeled fruit                5.000000   1.000  1.000  
11000081 11   Apple, peeled fruit-babyfood       5.000000   1.000  1.000  
11000090 11   Apple, dried                       5.000000   8.000  1.000  
11000091 11   Apple, dried-babyfood              5.000000   8.000  1.000  
11000100 11   Apple, juice                       5.000000   1.300  1.000  
11000101 11   Apple, juice-babyfood              5.000000   1.300  1.000  
11000110 11   Apple, sauce                       5.000000   1.000  1.000  
11000111 11   Apple, sauce-babyfood              5.000000   1.000  1.000  
11001290 11   Crabapple                          5.000000   1.000  1.000  
11002100 11   Loquat                             5.000000   1.000  1.000  
11002660 11   Pear                               5.000000   1.000  1.000  
11002661 11   Pear-babyfood                      5.000000   1.000  1.000  
11002670 11   Pear, dried                        5.000000   6.250  1.000  
11002680 11   Pear, juice                        5.000000   1.000  1.000  
11002681 11   Pear, juice-babyfood               5.000000   1.000  1.000  
11003100 11   Quince                             5.000000   1.000  1.000  
12000120 12   Apricot                            5.000000   1.000  1.000  
12000121 12   Apricot-babyfood                   5.000000   1.000  1.000  
12000130 12   Apricot, dried                     5.000000   6.000  1.000  
12000140 12   Apricot, juice                     5.000000   1.000  1.000  
12000141 12   Apricot, juice-babyfood            5.000000   1.000  1.000  
12000900 12   Cherry                             5.000000   1.000  1.000  
12000901 12   Cherry-babyfood                    5.000000   1.000  1.000  
12000910 12   Cherry, juice                      5.000000   1.500  1.000  
12000911 12   Cherry, juice-babyfood             5.000000   1.500  1.000  
12002300 12   Nectarine                          5.000000   1.000  1.000  
12002600 12   Peach                              5.000000   1.000  1.000  
12002601 12   Peach-babyfood                     5.000000   1.000  1.000  
12002610 12   Peach, dried                       5.000000   7.000  1.000  
12002611 12   Peach, dried-babyfood              5.000000   7.000  1.000  
12002620 12   Peach, juice                       5.000000   1.000  1.000  
12002621 12   Peach, juice-babyfood              5.000000   1.000  1.000  
12002850 12   Plum                               5.000000   1.000  1.000  
12002851 12   Plum-babyfood                      5.000000   1.000  1.000  
12002860 12   Plum, prune, fresh                 5.000000   1.000  1.000  
12002861 12   Plum, prune, fresh-babyfood        5.000000   1.000  1.000  
12002870 12   Plum, prune, dried                 5.000000   5.000  1.000  
12002871 12   Plum, prune, dried-babyfood        5.000000   5.000  1.000  
12002880 12   Plum, prune, juice                 5.000000   1.400  1.000  
12002881 12   Plum, prune, juice-babyfood        5.000000   1.400  1.000  
13010550 13A  Blackberry                         5.000000   1.000  1.000  
13010560 13A  Blackberry, juice                  5.000000   1.000  1.000  
13010561 13A  Blackberry, juice-babyfood         5.000000   1.000  1.000  
13010580 13A  Boysenberry                        5.000000   1.000  1.000  
13011420 13A  Dewberry                           5.000000   1.000  1.000  
13012080 13A  Loganberry                         5.000000   1.000  1.000  
13013200 13A  Raspberry                          5.000000   1.000  1.000  
13013201 13A  Raspberry-babyfood                 5.000000   1.000  1.000  
13013210 13A  Raspberry, juice                   5.000000   1.000  1.000  
13013211 13A  Raspberry, juice-babyfood          5.000000   1.000  1.000  
13020570 13B  Blueberry                          3.000000   1.000  1.000  
13020571 13B  Blueberry-babyfood                 3.000000   1.000  1.000  
13021360 13B  Currant                            2.000000   1.000  1.000  
13021370 13B  Currant, dried                     2.000000   1.000  1.000  
13021490 13B  Elderberry                         2.000000   1.000  1.000  
13021740 13B  Gooseberry                         2.000000   1.000  1.000  
13021910 13B  Huckleberry                        2.000000   1.000  1.000  
14002820 14   Pistachio                          0.100000   1.000  1.000  
15000250 15   Barley, pearled barley             0.020000   1.000  1.000  
15000251 15   Barley, pearled barley-babyfood    0.020000   1.000  1.000  
15000260 15   Barley, flour                      0.020000   1.000  1.000  
15000261 15   Barley, flour-babyfood             0.020000   1.000  1.000  
15000270 15   Barley, bran                       0.020000   1.000  1.000  
15000650 15   Buckwheat                          0.020000   1.000  1.000  
15000660 15   Buckwheat, flour                   0.020000   1.000  1.000  
15001200 15   Corn, field, flour                 0.020000   1.000  1.000  
15001201 15   Corn, field, flour-babyfood        0.020000   1.000  1.000  
15001210 15   Corn, field, meal                  0.020000   1.000  1.000  
15001211 15   Corn, field, meal-babyfood         0.020000   1.000  1.000  
15001220 15   Corn, field, bran                  0.020000   1.000  1.000  
15001230 15   Corn, field, starch                0.020000   1.000  1.000  
15001231 15   Corn, field, starch-babyfood       0.020000   1.000  1.000  
15001240 15   Corn, field, syrup                 0.020000   1.500  1.000  
15001241 15   Corn, field, syrup-babyfood        0.020000   1.500  1.000  
15001250 15   Corn, field, oil                   0.020000   1.000  1.000  
15001251 15   Corn, field, oil-babyfood          0.020000   1.000  1.000  
15001260 15   Corn, pop                          0.020000   1.000  1.000  
15001270 15   Corn, sweet                        0.020000   1.000  1.000  
15001271 15   Corn, sweet-babyfood               0.020000   1.000  1.000  
15002260 15   Millet, grain                      0.020000   1.000  1.000  
15002310 15   Oat, bran                          0.020000   1.000  1.000  
15002320 15   Oat, flour                         0.020000   1.000  1.000  
15002321 15   Oat, flour-babyfood                0.020000   1.000  1.000  
15002330 15   Oat, groats/rolled oats            0.020000   1.000  1.000  
15002331 15   Oat, groats/rolled oats-babyfood   0.020000   1.000  1.000  
15003230 15   Rice, white                        0.020000   1.000  1.000  
15003231 15   Rice, white-babyfood               0.020000   1.000  1.000  
15003240 15   Rice, brown                        0.020000   1.000  1.000  
15003241 15   Rice, brown-babyfood               0.020000   1.000  1.000  
15003250 15   Rice, flour                        0.020000   1.000  1.000  
15003251 15   Rice, flour-babyfood               0.020000   1.000  1.000  
15003260 15   Rice, bran                         0.020000   1.000  1.000  
15003261 15   Rice, bran-babyfood                0.020000   1.000  1.000  
15003280 15   Rye, grain                         0.020000   1.000  1.000  
15003290 15   Rye, flour                         0.020000   1.000  1.000  
15003440 15   Sorghum, grain                     0.020000   1.000  1.000  
15003450 15   Sorghum, syrup                     0.020000   1.000  1.000  
15003810 15   Triticale, flour                   0.020000   1.000  1.000  
15003811 15   Triticale, flour-babyfood          0.020000   1.000  1.000  
15004010 15   Wheat, grain                       0.020000   1.000  1.000  
15004011 15   Wheat, grain-babyfood              0.020000   1.000  1.000  
15004020 15   Wheat, flour                       0.020000   1.000  1.000  
15004021 15   Wheat, flour-babyfood              0.020000   1.000  1.000  
15004030 15   Wheat, germ                        0.020000   1.000  1.000  
15004040 15   Wheat, bran                        0.020000   1.000  1.000  
15004050 15   Wild rice                          0.020000   1.000  1.000  
19010280 19A  Basil, fresh leaves               10.000000   1.000  1.000  
19010281 19A  Basil, fresh leaves-babyfood      10.000000   1.000  1.000  
19010290 19A  Basil, dried leaves               65.000000   1.000  1.000  
19010291 19A  Basil, dried leaves-babyfood      65.000000   1.000  1.000  
19011030 19A  Chive                             10.000000   1.000  1.000  
19011180 19A  Coriander, leaves                 10.000000   1.000  1.000  
19011181 19A  Coriander, leaves-babyfood        10.000000   1.000  1.000  
19011440 19A  Dillweed                          10.000000   1.000  1.000  
19011840 19A  Herbs, other                      65.000000   1.000  1.000  
19011841 19A  Herbs, other-babyfood             65.000000   1.000  1.000  
19012020 19A  Lemongrass                        10.000000   1.000  1.000  
19012200 19A  Marjoram                          10.000000   1.000  1.000  
19012201 19A  Marjoram-babyfood                 10.000000   1.000  1.000  
19012490 19A  Parsley, dried leaves             65.000000   1.000  1.000  
19012491 19A  Parsley, dried leaves-babyfood    65.000000   1.000  1.000  
19013340 19A  Savory                            10.000000   1.000  1.000  
19021050 19B  Cinnamon                           0.020000   1.000  1.000  
19021051 19B  Cinnamon-babyfood                  0.020000   1.000  1.000  
19021190 19B  Coriander, seed                    0.020000   1.000  1.000  
19021191 19B  Coriander, seed-babyfood           0.020000   1.000  1.000  
19021430 19B  Dill, seed                         0.020000   1.000  1.000  
19022740 19B  Pepper, black and white            0.020000   1.000  1.000  
19022741 19B  Pepper, black and white-babyfood   0.020000   1.000  1.000  
19023540 19B  Spices, other                      0.020000   1.000  1.000  
19023541 19B  Spices, other-babyfood             0.020000   1.000  1.000  
20001630 20   Flaxseed, oil                      0.050000   1.000  1.000  
20003190 20   Rapeseed, oil                      0.010000   1.000  1.000  
20003191 20   Rapeseed, oil-babyfood             0.010000   1.000  1.000  
20003300 20   Safflower, oil                     0.010000   1.000  1.000  
20003301 20   Safflower, oil-babyfood            0.010000   1.000  1.000  
20003640 20   Sunflower, seed                    0.010000   1.000  1.000  
20003650 20   Sunflower, oil                     0.010000   1.000  1.000  
20003651 20   Sunflower, oil-babyfood            0.010000   1.000  1.000  
21000440 M    Beef, meat                         0.010000   1.000  1.000  
21000441 M    Beef, meat-babyfood                0.010000   1.000  1.000  
21000450 M    Beef, meat, dried                  0.010000   1.920  1.000  
21000460 M    Beef, meat byproducts              0.050000   1.000  1.000  
21000461 M    Beef, meat byproducts-babyfood     0.050000   1.000  1.000  
21000470 M    Beef, fat                          0.050000   1.000  1.000  
21000471 M    Beef,fat-babyfood                  0.050000   1.000  1.000  
21000480 M    Beef, kidney                       0.050000   1.000  1.000  
21000490 M    Beef, liver                        0.050000   1.000  1.000  
21000491 M    Beef, liver-babyfood               0.050000   1.000  1.000  
23001690 M    Goat, meat                         0.010000   1.000  1.000  
23001700 M    Goat, meat byproducts              0.050000   1.000  1.000  
23001710 M    Goat, fat                          0.050000   1.000  1.000  
23001720 M    Goat, kidney                       0.050000   1.000  1.000  
23001730 M    Goat, liver                        0.050000   1.000  1.000  
24001890 M    Horse, meat                        0.010000   1.000  1.000  
26003390 M    Sheep, meat                        0.010000   1.000  1.000  
26003391 M    Sheep, meat-babyfood               0.010000   1.000  1.000  
26003400 M    Sheep, meat byproducts             0.050000   1.000  1.000  
26003410 M    Sheep, fat                         0.050000   1.000  1.000  
26003411 M    Sheep, fat-babyfood                0.050000   1.000  1.000  
26003420 M    Sheep, kidney                      0.050000   1.000  1.000  
26003430 M    Sheep, liver                       0.050000   1.000  1.000  
27002220 D    Milk, fat                          0.010000   1.000  1.000  
27002221 D    Milk, fat - baby food/infant for   0.010000   1.000  1.000  
27012230 D    Milk, nonfat solids                0.010000   1.000  1.000  
27012231 D    Milk, nonfat solids-baby food/in   0.010000   1.000  1.000  
27022240 D    Milk, water                        0.010000   1.000  1.000  
27022241 D    Milk, water-babyfood/infant form   0.010000   1.000  1.000  
27032251 D    Milk, sugar (lactose)-baby food/   0.010000   1.000  1.000  
86010000 O    Water, direct, all sources         0.083800   1.000  1.000   
86020000 O    Water, indirect, all sources       0.083800   1.000  1.000   
95000010 O    Acerola                            5.000000   1.000  1.000  
95000200 O    Avocado                            5.000000   1.000  1.000   
95000740 O    Canistel                           5.000000   1.000  1.000   
95000890 O    Cherimoya                         20.000000   1.000  1.000  
95001280 O    Cottonseed, oil                    0.050000   1.000  1.000  
95001281 O    Cottonseed, oil-babyfood           0.050000   1.000  1.000  
95001510 O    Feijoa                             5.000000   1.000  1.000  
95001750 O    Grape                              2.000000   1.000  1.000  
95001760 O    Grape, juice                       2.000000   1.200  1.000  
95001761 O    Grape, juice-babyfood              2.000000   1.200  1.000  
95001770 O    Grape, leaves                      2.000000   1.000  1.000  
95001780 O    Grape, raisin                      2.000000   4.300  1.000  
95001790 O    Grape, wine and sherry             2.000000   1.000  1.000  
95001830 O    Guava                              5.000000   1.000  1.000  
95001831 O    Guava-babyfood                     5.000000   1.000  1.000  
95001920 O    Jaboticaba                         5.000000   1.000  1.000  
95001950 O    Kiwifruit                         20.000000   1.000  1.000  
95002090 O    Longan                            20.000000   1.000  1.000  
95002110 O    Lychee                            20.000000   1.000  1.000  
95002120 O    Lychee, dried                     20.000000   1.850  1.000  
95002150 O    Mango                              5.000000   1.000  1.000   
95002151 O    Mango-babyfood                     5.000000   1.000  1.000   
95002160 O    Mango, dried                       5.000000   1.000  1.000   
95002170 O    Mango, juice                       5.000000   1.000  1.000   
95002171 O    Mango, juice-babyfood              5.000000   1.000  1.000   
95002450 O    Papaya                             5.000000   1.000  1.000   
95002451 O    Papaya-babyfood                    5.000000   1.000  1.000   
95002460 O    Papaya, dried                      5.000000   1.800  1.000   
95002470 O    Papaya, juice                      5.000000   1.500  1.000   
95002520 O    Passionfruit                       5.000000   1.000  1.000  
95002521 O    Passionfruit-babyfood              5.000000   1.000  1.000  
95002530 O    Passionfruit, juice                5.000000   1.000  1.000  
95002531 O    Passionfruit, juice-babyfood       5.000000   1.000  1.000  
95002630 O    Peanut                             0.010000   1.000  1.000  
95002640 O    Peanut, butter                     0.010000   1.890  1.000  
95002650 O    Peanut, oil                        0.010000   1.000  1.000  
95002790 O    Pineapple                         20.000000   1.000  1.000  
95002791 O    Pineapple-babyfood                20.000000   1.000  1.000  
95002800 O    Pineapple, dried                  20.000000   5.000  1.000  
95002810 O    Pineapple, juice                  20.000000   1.700  1.000  
95002811 O    Pineapple, juice-babyfood         20.000000   1.700  1.000  
95002890 O    Pomegranate                        5.000000   1.000  1.000   
95003330 O    Sapote, Mamey                      5.000000   1.000  1.000   
95003460 O    Soursop                           20.000000   1.000  1.000  
95003510 O    Spanish lime                      20.000000   1.000  1.000  
95003580 O    Starfruit                          5.000000   1.000  1.000   
95003590 O    Strawberry                         3.000000   1.000  1.000  
95003591 O    Strawberry-babyfood                3.000000   1.000  1.000  
95003600 O    Strawberry, juice                  3.000000   1.000  1.000  
95003601 O    Strawberry, juice-babyfood         3.000000   1.000  1.000  
95003610 O    Sugar apple                       20.000000   1.000  1.000  
95003800 O    Tomato, Tree                       5.000000   1.000  1.000  
95003980 O    Watercress                         7.000000   1.000  1.000  
Attachment 2:	DEEM-FCID[(TM)] Acute Exposure and Risk Estimates

U.S. Environmental Protection Agency                                  Ver. 2.02
DEEM-FCID ACUTE Analysis for FLUDIOXONIL                         (1994-98 data)
Residue file: 2012_071503a.R98                        Adjustment factor #2 used.
Analysis Date: 05-22-2012/15:59:13    Residue file dated: 05-22-2012/15:58:30/8
NOEL (Acute) = 100.000000 mg/kg body-wt/day
Daily totals for food and foodform consumption used.
Run Comment: "DPR Work-share Acute/Chronic Dietary with new FY04 Section 3 Tol
erances"
===============================================================================

Summary calculations (per capita):

      95th Percentile             99th Percentile             99.9th Percentile
 Exposure  % aRfD     MOE    Exposure  % aRfD     MOE    Exposure  % aRfD     MOE  
---------- ------- -------- ---------- ------- -------- ---------- ------- --------
Females 13-49 yrs:
  0.164096   16.41     609    0.284802   28.48     351    0.610556   61.06     163  

Attachment 3:	DEEM-FCID[(TM)] Chronic Residue File
Filename: C:\Documents and Settings\gkramer\My Documents\Gk\##Fludioxonil\2012_071503c_Harm.R98
Chemical: Fludioxonil
RfD(Chronic): .033 mg/kg bw/day  NOEL(Chronic): 3.3 mg/kg bw/day
RfD(Acute): 1 mg/kg bw/day  NOEL(Acute):  100 mg/kg bw/day
Date created/last modified: 05-17-2012/13:27:02/8          Program ver. 2.03
Comment: DPR Work-share Acute/Chronic Dietary with new FY04 Section 3 Tolerances
--------------------------------------------------------------------------------
  EPA    Crop                                   Def Res     Adj.Factors   Comment
  Code    Grp  Commodity Name                    (ppm)       #1    #2   
-------- ---- -------------------------------  ----------  ------ ------  -------
01010500 1AB  Beet, garden, roots                0.750000   1.000  1.000  
01010501 1AB  Beet, garden, roots-babyfood       0.750000   1.000  1.000  
01010520 1A   Beet, sugar                        0.020000   1.000  1.000  
01010521 1A   Beet, sugar-babyfood               0.020000   1.000  1.000  
01010530 1A   Beet, sugar, molasses              0.020000   1.000  1.000  
01010531 1A   Beet, sugar, molasses-babyfood     0.020000   1.000  1.000  
01010670 1AB  Burdock                            0.750000   1.000  1.000  
01010780 1AB  Carrot                             0.750000   1.000  1.000  
01010781 1AB  Carrot-babyfood                    0.750000   1.000  1.000  
01010790 1AB  Carrot, juice                      0.750000   1.000  1.000  
01010840 1AB  Celeriac                           0.750000   1.000  1.000  
01011000 1AB  Chicory, roots                     0.750000   1.000  1.000  
01011680 1AB  Ginseng, dried                     4.000000   1.000  1.000  
01011900 1AB  Horseradish                        0.750000   1.000  1.000  
01012500 1AB  Parsley, turnip rooted             0.750000   1.000  1.000  
01012510 1AB  Parsnip                            0.750000   1.000  1.000  
01012511 1AB  Parsnip-babyfood                   0.750000   1.000  1.000  
01013140 1AB  Radish, roots                      0.750000   1.000  1.000  
01013160 1AB  Radish, Oriental, roots            0.750000   1.000  1.000  
01013270 1AB  Rutabaga                           0.750000   1.000  1.000  
01013310 1AB  Salsify, roots                     0.750000   1.000  1.000  
01013880 1AB  Turnip, roots                      0.750000   1.000  1.000  
01030150 1CD  Arrowroot, flour                   6.000000   1.000  1.000   
01030151 1CD  Arrowroot, flour-babyfood          6.000000   1.000  1.000   
01030170 1CD  Artichoke, Jerusalem               6.000000   1.000  1.000   
01030820 1CD  Cassava                            6.000000   1.000  1.000   
01030821 1CD  Cassava-babyfood                   6.000000   1.000  1.000   
01031390 1CD  Dasheen, corm                      6.000000   1.000  1.000   
01031660 1CD  Ginger                             6.000000   1.000  1.000   
01031661 1CD  Ginger-babyfood                    6.000000   1.000  1.000   
01031670 1CD  Ginger, dried                      6.000000   1.000  1.000   
01032960 1C   Potato, chips                      1.820000   1.000  1.000  
01032970 1C   Potato, dry (granules/ flakes)     1.820000   1.000  1.000  
01032971 1C   Potato, dry (granules/ flakes)-b   1.820000   1.000  1.000  
01032980 1C   Potato, flour                      1.820000   1.000  1.000  
01032981 1C   Potato, flour-babyfood             1.820000   1.000  1.000  
01032990 1C   Potato, tuber, w/peel              1.820000   1.000  1.000  
01032991 1C   Potato, tuber, w/peel-babyfood     1.820000   1.000  1.000  
01033000 1C   Potato, tuber, w/o peel            1.820000   1.000  1.000  
01033001 1C   Potato, tuber, w/o peel-babyfood   1.820000   1.000  1.000  
01033660 1CD  Sweet potato                       6.000000   1.000  1.000   
01033661 1CD  Sweet potato-babyfood              6.000000   1.000  1.000   
01033710 1CD  Tanier, corm                       6.000000   1.000  1.000   
01033870 1CD  Turmeric                           6.000000   1.000  1.000   
01034060 1CD  Yam, true                          8.000000   1.000  1.000   
01034070 1CD  Yam bean                           6.000000   1.000  1.000   
02000510 2    Beet, garden, tops                30.000000   1.000  1.000  
02001010 2    Chicory, tops                     30.000000   1.000  1.000  
02001400 2    Dasheen, leaves                   30.000000   1.000  1.000  
02003150 2    Radish, tops                      30.000000   1.000  1.000  
02003170 2    Radish, Oriental, tops            30.000000   1.000  1.000  
02003320 2    Salsify, tops                     30.000000   1.000  1.000  
03001640 3    Garlic                             0.500000   1.000  1.000  
03001650 3    Garlic, dried                      0.500000   1.000  1.000  
03001651 3    Garlic, dried-babyfood             0.500000   1.000  1.000  
03001980 3    Leek                               7.000000   1.000  1.000  
03002370 3    Onion, dry bulb                    0.500000   1.000  1.000  
03002371 3    Onion, dry bulb-babyfood           0.500000   1.000  1.000  
03002380 3    Onion, dry bulb, dried             0.500000   9.000  1.000  
03002381 3    Onion, dry bulb, dried-babyfood    0.500000   9.000  1.000  
03002390 3    Onion, green                       7.000000   1.000  1.000  
03003380 3    Shallot                            0.500000   1.000  1.000  
04010050 4A   Amaranth, leafy                   30.000000   1.000  1.000  
04010180 4A   Arugula                           30.000000   1.000  1.000  
04011040 4A   Chrysanthemum, garland            30.000000   1.000  1.000  
04011330 4A   Cress, garden                     30.000000   1.000  1.000  
04011340 4A   Cress, upland                     30.000000   1.000  1.000  
04011380 4A   Dandelion, leaves                 30.000000   1.000  1.000  
04011500 4A   Endive                            30.000000   1.000  1.000  
04012040 4A   Lettuce, head                      2.090000   1.000  1.000  AR hea
          Full comment: AR head lettuce (w/ wrapper leaves)
04012050 4A   Lettuce, leaf                     10.770000   1.000  1.000  AR lea
          Full comment: AR leaf lettuce
04012480 4A   Parsley, leaves                    1.230000   1.000  1.000  AR; pa
          Full comment: AR; parsely field trials
04013130 4A   Radicchio                         30.000000   1.000  1.000  
04013550 4A   Spinach                            7.100000   1.000  1.000  
04013551 4A   Spinach-babyfood                   7.100000   1.000  1.000  
04020760 4B   Cardoon                           15.000000   1.000  1.000  
04020850 4B   Celery                             4.900000   1.000  1.000  
04020851 4B   Celery-babyfood                    4.900000   1.000  1.000  
04020860 4B   Celery, juice                      4.900000   1.000  1.000  
04020870 4B   Celtuce                           15.000000   1.000  1.000  
04021520 4B   Fennel, Florence                  15.000000   1.000  1.000  
04023220 4B   Rhubarb                           15.000000   1.000  1.000  
04023670 4B   Swiss chard                       15.000000   1.000  1.000  
05010610 5A   Broccoli                           0.130000   1.000  1.000  AR; DP
          Full comment: AR; DP#345970
05010611 5A   Broccoli-babyfood                  0.130000   1.000  1.000  AR; DP
          Full comment: AR; DP#345970
05010620 5A   Broccoli, Chinese                  0.130000   1.000  1.000  AR; DP
          Full comment: AR; DP#345970
05010640 5A   Brussels sprouts                   0.340000   1.000  1.000  AR; DP
          Full comment: AR; DP#345970
05010690 5A   Cabbage                            0.340000   1.000  1.000  AR; DP
          Full comment: AR; DP#345970
05010710 5A   Cabbage, Chinese, napa             0.340000   1.000  1.000  AR; DP
          Full comment: AR; DP#345970
05010720 5A   Cabbage, Chinese, mustard          0.130000   1.000  1.000  AR; DP
          Full comment: AR; DP#345970
05010830 5A   Cauliflower                        0.130000   1.000  1.000  AR; DP
          Full comment: AR; DP#345970
05011960 5A   Kohlrabi                           0.340000   1.000  1.000  AR; DP
          Full comment: AR; DP#345970
05020630 5B   Broccoli raab                      1.030000   1.000  1.000  AR; DP
          Full comment: AR; DP#345970
05020700 5B   Cabbage, Chinese, bok choy         1.030000   1.000  1.000  AR; DP
          Full comment: AR; DP#345970
05021170 5B   Collards                           1.030000   1.000  1.000  AR; DP
          Full comment: AR; DP#345970
05021940 5B   Kale                               1.030000   1.000  1.000  AR; DP
          Full comment: AR; DP#345970
05022290 5B   Mustard greens                     1.030000   1.000  1.000  AR; DP
          Full comment: AR; DP#345970
05023180 5B   Rape greens                        1.030000   1.000  1.000  AR; DP
          Full comment: AR; DP#345970
05023890 5B   Turnip, greens                    10.000000   1.000  1.000  
06003470 6    Soybean, seed                      0.010000   1.000  1.000  
06003480 6    Soybean, flour                     0.010000   1.000  1.000  
06003481 6    Soybean, flour-babyfood            0.010000   1.000  1.000  
06003490 6    Soybean, soy milk                  0.010000   1.000  1.000  
06003491 6    Soybean, soy milk-babyfood or in   0.010000   1.000  1.000  
06003500 6    Soybean, oil                       0.010000   1.000  1.000  
06003501 6    Soybean, oil-babyfood              0.010000   1.000  1.000  
06010430 6A   Bean, snap, succulent              0.400000   1.000  1.000  
06010431 6A   Bean, snap, succulent-babyfood     0.400000   1.000  1.000  
06012570 6A   Pea, edible podded, succulent      0.010000   1.000  1.000  
06020310 6B   Bean, broad, succulent             0.400000   1.000  1.000  
06020330 6B   Bean, cowpea, succulent            0.400000   1.000  1.000  
06020370 6B   Bean, lima, succulent              0.400000   1.000  1.000  
06022550 6B   Pea, succulent                     0.010000   1.000  1.000  
06022551 6B   Pea, succulent-babyfood            0.010000   1.000  1.000  
06022590 6B   Pea, pigeon, succulent             0.010000   1.000  1.000  
06030300 6C   Bean, black, seed                  0.400000   1.000  1.000  
06030320 6C   Bean, broad, seed                  0.400000   1.000  1.000  
06030340 6C   Bean, cowpea, seed                 0.400000   1.000  1.000  
06030350 6C   Bean,  great northern, seed        0.400000   1.000  1.000  
06030360 6C   Bean, kidney, seed                 0.400000   1.000  1.000  
06030380 6C   Bean, lima, seed                   0.400000   1.000  1.000  
06030390 6C   Bean, mung, seed                   0.400000   1.000  1.000  
06030400 6C   Bean, navy, seed                   0.400000   1.000  1.000  
06030410 6C   Bean, pink, seed                   0.400000   1.000  1.000  
06030420 6C   Bean, pinto, seed                  0.400000   1.000  1.000  
06030980 6C   Chickpea, seed                     0.400000   1.000  1.000  
06030981 6C   Chickpea, seed-babyfood            0.400000   1.000  1.000  
06030990 6C   Chickpea, flour                    0.400000   1.000  1.000  
06031820 6C   Guar, seed                         0.400000   1.000  1.000  
06031821 6C   Guar, seed-babyfood                0.400000   1.000  1.000  
06032030 6C   Lentil, seed                       0.400000   1.000  1.000  
06032560 6C   Pea, dry                           0.010000   1.000  1.000  
06032561 6C   Pea, dry-babyfood                  0.010000   1.000  1.000  
06032580 6C   Pea, pigeon, seed                  0.010000   1.000  1.000  
08001480 8    Eggplant                           0.500000   1.000  1.000  
08002340 8    Okra                               0.500000   1.000  1.000  
08002700 8    Pepper, bell                       0.500000   1.000  1.000  
08002701 8    Pepper, bell-babyfood              0.500000   1.000  1.000  
08002710 8    Pepper, bell, dried                0.500000   1.000  1.000  
08002711 8    Pepper, bell, dried-babyfood       0.500000   1.000  1.000  
08002720 8    Pepper, nonbell                    0.500000   1.000  1.000  
08002721 8    Pepper, nonbell-babyfood           0.500000   1.000  1.000  
08002730 8    Pepper, nonbell, dried             0.500000   1.000  1.000  
08003740 8    Tomatillo                          0.500000   1.000  1.000  AR
08003750 8    Tomato                             0.890000   1.000  1.000  AR
08003751 8    Tomato-babyfood                    0.890000   1.000  1.000  AR
08003760 8    Tomato, paste                      0.890000   1.000  1.000  AR; pr
          Full comment: AR; processing study
08003761 8    Tomato, paste-babyfood             0.890000   1.000  1.000  AR; pr
          Full comment: AR; processing study
08003770 8    Tomato, puree                      0.890000   1.000  1.000  AR; pr
          Full comment: AR; processing study
08003771 8    Tomato, puree-babyfood             0.890000   1.000  1.000  AR; pr
          Full comment: AR; processing study
08003780 8    Tomato, dried                      0.890000  14.300  1.000  AR
08003781 8    Tomato, dried-babyfood             0.890000  14.300  1.000  AR
08003790 8    Tomato, juice                      0.890000   1.000  1.000  AR; pr
          Full comment: AR; processing study
09010750 9A   Cantaloupe                         0.450000   1.000  1.000   
09010800 9A   Casaba                             0.450000   1.000  1.000   
09011870 9A   Honeydew melon                     0.450000   1.000  1.000   
09013990 9A   Watermelon                         0.450000   1.000  1.000   
09014000 9A   Watermelon, juice                  0.450000   1.000  1.000   
09020210 9B   Balsam pear                        0.450000   1.000  1.000   
09020880 9B   Chayote, fruit                     0.450000   1.000  1.000   
09021020 9B   Chinese waxgourd                   0.450000   1.000  1.000   
09021350 9B   Cucumber                           0.450000   1.000  1.000   
09023080 9B   Pumpkin                            0.450000   1.000  1.000   
09023090 9B   Pumpkin, seed                      0.450000   1.000  1.000   
09023560 9B   Squash, summer                     0.450000   1.000  1.000   
09023561 9B   Squash, summer-babyfood            0.450000   1.000  1.000   
09023570 9B   Squash, winter                     0.450000   1.000  1.000   
09023571 9B   Squash, winter-babyfood            0.450000   1.000  1.000   
10001060 10   Citrus citron                     10.000000   1.000  1.000  
10001070 10   Citrus hybrids                    10.000000   1.000  1.000  
10001080 10   Citrus, oil                      500.000000   1.000  1.000  
10001800 10   Grapefruit                         2.600000   1.000  1.000  AR
10001810 10   Grapefruit, juice                  0.740000   1.000  1.000  AR
10001970 10   Kumquat                           10.000000   1.000  1.000  
10001990 10   Lemon                              1.700000   1.000  1.000  AR
10002000 10   Lemon, juice                       0.020000   1.000  1.000  AR
10002001 10   Lemon, juice-babyfood              0.020000   1.000  1.000  AR
10002010 10   Lemon, peel                        1.700000   1.000  1.000  AR
10002060 10   Lime                               1.700000   1.000  1.000  AR
10002070 10   Lime, juice                        0.020000   1.000  1.000  AR
10002071 10   Lime, juice-babyfood               0.020000   1.000  1.000  AR
10002400 10   Orange                             1.500000   1.000  1.000  AR
10002420 10   Orange, peel                       1.500000   1.000  1.000  AR
10003070 10   Pummelo                           10.000000   1.000  1.000  
10003690 10   Tangerine                          1.500000   1.000  1.000  AR
10003700 10   Tangerine, juice                   0.740000   1.000  1.000  AR
11000070 11   Apple, fruit with peel             1.100000   1.000  1.000  AR
11000080 11   Apple, peeled fruit                1.100000   1.000  1.000  AR
11000081 11   Apple, peeled fruit-babyfood       1.100000   1.000  1.000  AR
11000090 11   Apple, dried                       1.100000   8.000  1.000  AR
11000091 11   Apple, dried-babyfood              1.100000   8.000  1.000  AR
11000100 11   Apple, juice                       0.100000   1.000  1.000  AR
11000101 11   Apple, juice-babyfood              0.100000   1.000  1.000  AR
11000110 11   Apple, sauce                       1.100000   1.000  1.000  AR
11000111 11   Apple, sauce-babyfood              1.100000   1.000  1.000  AR
11001290 11   Crabapple                          5.000000   1.000  1.000  
11002100 11   Loquat                             5.000000   1.000  1.000  
11002660 11   Pear                               1.600000   1.000  1.000  AR
11002661 11   Pear-babyfood                      1.600000   1.000  1.000  AR
11002670 11   Pear, dried                        1.600000   6.250  1.000  AR
11002680 11   Pear, juice                        1.600000   1.000  1.000  AR
11002681 11   Pear, juice-babyfood               1.600000   1.000  1.000  AR
11003100 11   Quince                             5.000000   1.000  1.000  
12000120 12   Apricot                            5.000000   1.000  1.000  
12000121 12   Apricot-babyfood                   5.000000   1.000  1.000  
12000130 12   Apricot, dried                     5.000000   6.000  1.000  
12000140 12   Apricot, juice                     5.000000   1.000  1.000  
12000141 12   Apricot, juice-babyfood            5.000000   1.000  1.000  
12000900 12   Cherry                             0.820000   1.000  1.000  AR
12000901 12   Cherry-babyfood                    0.820000   1.000  1.000  AR
12000910 12   Cherry, juice                      0.820000   1.500  1.000  AR
12000911 12   Cherry, juice-babyfood             0.820000   1.500  1.000  AR
12002300 12   Nectarine                          5.000000   1.000  1.000  
12002600 12   Peach                              0.400000   1.000  1.000  AR
12002601 12   Peach-babyfood                     0.400000   1.000  1.000  AR
12002610 12   Peach, dried                       0.400000   7.000  1.000  AR
12002611 12   Peach, dried-babyfood              0.400000   7.000  1.000  AR
12002620 12   Peach, juice                       0.400000   1.000  1.000  AR
12002621 12   Peach, juice-babyfood              0.400000   1.000  1.000  AR
12002850 12   Plum                               0.510000   1.000  1.000  AR
12002851 12   Plum-babyfood                      0.510000   1.000  1.000  AR
12002860 12   Plum, prune, fresh                 0.510000   1.000  1.000  AR
12002861 12   Plum, prune, fresh-babyfood        0.510000   1.000  1.000  AR
12002870 12   Plum, prune, dried                 0.510000   5.000  1.000  AR
12002871 12   Plum, prune, dried-babyfood        0.510000   5.000  1.000  AR
12002880 12   Plum, prune, juice                 0.510000   1.400  1.000  AR
12002881 12   Plum, prune, juice-babyfood        0.510000   1.400  1.000  AR
13010550 13A  Blackberry                         5.000000   1.000  1.000  
13010560 13A  Blackberry, juice                  5.000000   1.000  1.000  
13010561 13A  Blackberry, juice-babyfood         5.000000   1.000  1.000  
13010580 13A  Boysenberry                        5.000000   1.000  1.000  
13011420 13A  Dewberry                           5.000000   1.000  1.000  
13012080 13A  Loganberry                         5.000000   1.000  1.000  
13013200 13A  Raspberry                          5.000000   1.000  1.000  
13013201 13A  Raspberry-babyfood                 5.000000   1.000  1.000  
13013210 13A  Raspberry, juice                   5.000000   1.000  1.000  
13013211 13A  Raspberry, juice-babyfood          5.000000   1.000  1.000  
13020570 13B  Blueberry                          3.000000   1.000  1.000  
13020571 13B  Blueberry-babyfood                 3.000000   1.000  1.000  
13021360 13B  Currant                            2.000000   1.000  1.000  
13021370 13B  Currant, dried                     2.000000   1.000  1.000  
13021490 13B  Elderberry                         2.000000   1.000  1.000  
13021740 13B  Gooseberry                         2.000000   1.000  1.000  
13021910 13B  Huckleberry                        2.000000   1.000  1.000  
14002820 14   Pistachio                          0.100000   1.000  1.000  
15000250 15   Barley, pearled barley             0.020000   1.000  1.000  
15000251 15   Barley, pearled barley-babyfood    0.020000   1.000  1.000  
15000260 15   Barley, flour                      0.020000   1.000  1.000  
15000261 15   Barley, flour-babyfood             0.020000   1.000  1.000  
15000270 15   Barley, bran                       0.020000   1.000  1.000  
15000650 15   Buckwheat                          0.020000   1.000  1.000  
15000660 15   Buckwheat, flour                   0.020000   1.000  1.000  
15001200 15   Corn, field, flour                 0.020000   1.000  1.000  
15001201 15   Corn, field, flour-babyfood        0.020000   1.000  1.000  
15001210 15   Corn, field, meal                  0.020000   1.000  1.000  
15001211 15   Corn, field, meal-babyfood         0.020000   1.000  1.000  
15001220 15   Corn, field, bran                  0.020000   1.000  1.000  
15001230 15   Corn, field, starch                0.020000   1.000  1.000  
15001231 15   Corn, field, starch-babyfood       0.020000   1.000  1.000  
15001240 15   Corn, field, syrup                 0.020000   1.500  1.000  
15001241 15   Corn, field, syrup-babyfood        0.020000   1.500  1.000  
15001250 15   Corn, field, oil                   0.020000   1.000  1.000  
15001251 15   Corn, field, oil-babyfood          0.020000   1.000  1.000  
15001260 15   Corn, pop                          0.020000   1.000  1.000  
15001270 15   Corn, sweet                        0.020000   1.000  1.000  
15001271 15   Corn, sweet-babyfood               0.020000   1.000  1.000  
15002260 15   Millet, grain                      0.020000   1.000  1.000  
15002310 15   Oat, bran                          0.020000   1.000  1.000  
15002320 15   Oat, flour                         0.020000   1.000  1.000  
15002321 15   Oat, flour-babyfood                0.020000   1.000  1.000  
15002330 15   Oat, groats/rolled oats            0.020000   1.000  1.000  
15002331 15   Oat, groats/rolled oats-babyfood   0.020000   1.000  1.000  
15003230 15   Rice, white                        0.020000   1.000  1.000  
15003231 15   Rice, white-babyfood               0.020000   1.000  1.000  
15003240 15   Rice, brown                        0.020000   1.000  1.000  
15003241 15   Rice, brown-babyfood               0.020000   1.000  1.000  
15003250 15   Rice, flour                        0.020000   1.000  1.000  
15003251 15   Rice, flour-babyfood               0.020000   1.000  1.000  
15003260 15   Rice, bran                         0.020000   1.000  1.000  
15003261 15   Rice, bran-babyfood                0.020000   1.000  1.000  
15003280 15   Rye, grain                         0.020000   1.000  1.000  
15003290 15   Rye, flour                         0.020000   1.000  1.000  
15003440 15   Sorghum, grain                     0.020000   1.000  1.000  
15003450 15   Sorghum, syrup                     0.020000   1.000  1.000  
15003810 15   Triticale, flour                   0.020000   1.000  1.000  
15003811 15   Triticale, flour-babyfood          0.020000   1.000  1.000  
15004010 15   Wheat, grain                       0.020000   1.000  1.000  
15004011 15   Wheat, grain-babyfood              0.020000   1.000  1.000  
15004020 15   Wheat, flour                       0.020000   1.000  1.000  
15004021 15   Wheat, flour-babyfood              0.020000   1.000  1.000  
15004030 15   Wheat, germ                        0.020000   1.000  1.000  
15004040 15   Wheat, bran                        0.020000   1.000  1.000  
15004050 15   Wild rice                          0.020000   1.000  1.000  
19010280 19A  Basil, fresh leaves               10.000000   1.000  1.000  
19010281 19A  Basil, fresh leaves-babyfood      10.000000   1.000  1.000  
19010290 19A  Basil, dried leaves               65.000000   1.000  1.000  
19010291 19A  Basil, dried leaves-babyfood      65.000000   1.000  1.000  
19011030 19A  Chive                             10.000000   1.000  1.000  
19011180 19A  Coriander, leaves                 10.000000   1.000  1.000  
19011181 19A  Coriander, leaves-babyfood        10.000000   1.000  1.000  
19011440 19A  Dillweed                          10.000000   1.000  1.000  
19011840 19A  Herbs, other                      65.000000   1.000  1.000  
19011841 19A  Herbs, other-babyfood             65.000000   1.000  1.000  
19012020 19A  Lemongrass                        10.000000   1.000  1.000  
19012200 19A  Marjoram                          10.000000   1.000  1.000  
19012201 19A  Marjoram-babyfood                 10.000000   1.000  1.000  
19012490 19A  Parsley, dried leaves             65.000000   1.000  1.000  
19012491 19A  Parsley, dried leaves-babyfood    65.000000   1.000  1.000  
19013340 19A  Savory                            10.000000   1.000  1.000  
19021050 19B  Cinnamon                           0.020000   1.000  1.000  
19021051 19B  Cinnamon-babyfood                  0.020000   1.000  1.000  
19021190 19B  Coriander, seed                    0.020000   1.000  1.000  
19021191 19B  Coriander, seed-babyfood           0.020000   1.000  1.000  
19021430 19B  Dill, seed                         0.020000   1.000  1.000  
19022740 19B  Pepper, black and white            0.020000   1.000  1.000  
19022741 19B  Pepper, black and white-babyfood   0.020000   1.000  1.000  
19023540 19B  Spices, other                      0.020000   1.000  1.000  
19023541 19B  Spices, other-babyfood             0.020000   1.000  1.000  
20001630 20   Flaxseed, oil                      0.050000   1.000  1.000  
20003190 20   Rapeseed, oil                      0.010000   1.000  1.000  
20003191 20   Rapeseed, oil-babyfood             0.010000   1.000  1.000  
20003300 20   Safflower, oil                     0.010000   1.000  1.000  
20003301 20   Safflower, oil-babyfood            0.010000   1.000  1.000  
20003640 20   Sunflower, seed                    0.010000   1.000  1.000  
20003650 20   Sunflower, oil                     0.010000   1.000  1.000  
20003651 20   Sunflower, oil-babyfood            0.010000   1.000  1.000  
21000440 M    Beef, meat                         0.010000   1.000  1.000  
21000441 M    Beef, meat-babyfood                0.010000   1.000  1.000  
21000450 M    Beef, meat, dried                  0.010000   1.920  1.000  
21000460 M    Beef, meat byproducts              0.050000   1.000  1.000  
21000461 M    Beef, meat byproducts-babyfood     0.050000   1.000  1.000  
21000470 M    Beef, fat                          0.050000   1.000  1.000  
21000471 M    Beef,fat-babyfood                  0.050000   1.000  1.000  
21000480 M    Beef, kidney                       0.050000   1.000  1.000  
21000490 M    Beef, liver                        0.050000   1.000  1.000  
21000491 M    Beef, liver-babyfood               0.050000   1.000  1.000  
23001690 M    Goat, meat                         0.010000   1.000  1.000  
23001700 M    Goat, meat byproducts              0.050000   1.000  1.000  
23001710 M    Goat, fat                          0.050000   1.000  1.000  
23001720 M    Goat, kidney                       0.050000   1.000  1.000  
23001730 M    Goat, liver                        0.050000   1.000  1.000  
24001890 M    Horse, meat                        0.010000   1.000  1.000  
26003390 M    Sheep, meat                        0.010000   1.000  1.000  
26003391 M    Sheep, meat-babyfood               0.010000   1.000  1.000  
26003400 M    Sheep, meat byproducts             0.050000   1.000  1.000  
26003410 M    Sheep, fat                         0.050000   1.000  1.000  
26003411 M    Sheep, fat-babyfood                0.050000   1.000  1.000  
26003420 M    Sheep, kidney                      0.050000   1.000  1.000  
26003430 M    Sheep, liver                       0.050000   1.000  1.000  
27002220 D    Milk, fat                          0.010000   1.000  1.000  
27002221 D    Milk, fat - baby food/infant for   0.010000   1.000  1.000  
27012230 D    Milk, nonfat solids                0.010000   1.000  1.000  
27012231 D    Milk, nonfat solids-baby food/in   0.010000   1.000  1.000  
27022240 D    Milk, water                        0.010000   1.000  1.000  
27022241 D    Milk, water-babyfood/infant form   0.010000   1.000  1.000  
27032251 D    Milk, sugar (lactose)-baby food/   0.010000   1.000  1.000  
86010000 O    Water, direct, all sources         0.038500   1.000  1.000    
86020000 O    Water, indirect, all sources       0.038500   1.000  1.000     
95000010 O    Acerola                            5.000000   1.000  1.000  
95000200 O    Avocado                            5.000000   1.000  1.000   
95000740 O    Canistel                           5.000000   1.000  1.000  
95000890 O    Cherimoya                         20.000000   1.000  1.000  
95001280 O    Cottonseed, oil                    0.050000   1.000  1.000  
95001281 O    Cottonseed, oil-babyfood           0.050000   1.000  1.000  
95001510 O    Feijoa                             5.000000   1.000  1.000  
95001750 O    Grape                              0.330000   1.000  1.000  AR; DP
          Full comment: AR; DP#348539
95001760 O    Grape, juice                       0.330000   0.420  1.000  AR; DP
          Full comment: AR; DP#348539
95001761 O    Grape, juice-babyfood              0.330000   0.420  1.000  AR; DP
          Full comment: AR; DP#348539
95001770 O    Grape, leaves                      0.330000   1.000  1.000  AR; DP
          Full comment: AR; DP#348539
95001780 O    Grape, raisin                      0.330000   1.650  1.000  AR; DP
          Full comment: AR; DP#348539
95001790 O    Grape, wine and sherry             0.330000   1.000  1.000  AR; DP
          Full comment: AR; DP#348539
95001830 O    Guava                              5.000000   1.000  1.000  
95001831 O    Guava-babyfood                     5.000000   1.000  1.000  
95001920 O    Jaboticaba                         5.000000   1.000  1.000  
95001950 O    Kiwifruit                         20.000000   1.000  1.000  
95002090 O    Longan                            20.000000   1.000  1.000  
95002110 O    Lychee                            20.000000   1.000  1.000  
95002120 O    Lychee, dried                     20.000000   1.850  1.000  
95002150 O    Mango                              5.000000   1.000  1.000   
95002151 O    Mango-babyfood                     5.000000   1.000  1.000   
95002160 O    Mango, dried                       5.000000   1.000  1.000   
95002170 O    Mango, juice                       5.000000   1.000  1.000   
95002171 O    Mango, juice-babyfood              5.000000   1.000  1.000   
95002450 O    Papaya                             5.000000   1.000  1.000   
95002451 O    Papaya-babyfood                    5.000000   1.000  1.000   
95002460 O    Papaya, dried                      5.000000   1.800  1.000   
95002470 O    Papaya, juice                      5.000000   1.500  1.000   
95002520 O    Passionfruit                       5.000000   1.000  1.000  
95002521 O    Passionfruit-babyfood              5.000000   1.000  1.000  
95002530 O    Passionfruit, juice                5.000000   1.000  1.000  
95002531 O    Passionfruit, juice-babyfood       5.000000   1.000  1.000  
95002630 O    Peanut                             0.010000   1.000  1.000  
95002640 O    Peanut, butter                     0.010000   1.890  1.000  
95002650 O    Peanut, oil                        0.010000   1.000  1.000  
95002790 O    Pineapple                          5.640000   1.000  1.000  
95002791 O    Pineapple-babyfood                 5.640000   1.000  1.000  
95002800 O    Pineapple, dried                   5.640000   5.000  1.000  
95002810 O    Pineapple, juice                   5.640000   1.000  1.000  
95002811 O    Pineapple, juice-babyfood          5.640000   1.000  1.000  
95002890 O    Pomegranate                        5.000000   1.000  1.000   
95003330 O    Sapote, Mamey                      5.000000   1.000  1.000  
95003460 O    Soursop                           20.000000   1.000  1.000  
95003510 O    Spanish lime                      20.000000   1.000  1.000  
95003580 O    Starfruit                          5.000000   1.000  1.000   
95003590 O    Strawberry                         3.000000   1.000  1.000  
95003591 O    Strawberry-babyfood                3.000000   1.000  1.000  
95003600 O    Strawberry, juice                  3.000000   1.000  1.000  
95003601 O    Strawberry, juice-babyfood         3.000000   1.000  1.000  
95003610 O    Sugar apple                       20.000000   1.000  1.000  
95003800 O    Tomato, Tree                       5.000000   1.000  1.000  
95003980 O    Watercress                         7.000000   1.000  1.000  
Attachment 4:	DEEM-FCID[(TM)] Chronic Exposure and Risk Estimates
U.S. Environmental Protection Agency                                 Ver. 2.00
DEEM-FCID Chronic analysis for FLUDIOXONIL                      (1994-98 data)
Residue file name: C:\Documents and Settings\gkramer\My Documents\Gk\##Fludioxonil\2012_071503c_Harm.R98
                                                     Adjustment factor #2 used.
Analysis Date 05-17-2012/13:29:15     Residue file dated: 05-17-2012/13:27:02/8
Reference dose (RfD, Chronic) = .033 mg/kg bw/day
COMMENT 1: DPR Work-share Acute/Chronic Dietary with new FY04 Section 3 Tolerances
===============================================================================
                    Total exposure by population subgroup
-------------------------------------------------------------------------------

                                                    Total Exposure
                                         -----------------------------------
          Population                         mg/kg             Percent of   
           Subgroup                       body wt/day             Rfd       
--------------------------------------   -------------       ---------------
U.S. Population (total)                     0.008711                26.4%

U.S. Population (spring season)             0.008905                27.0%
U.S. Population (summer season)             0.008622                26.1%
U.S. Population (autumn season)             0.008578                26.0%
U.S. Population (winter season)             0.008755                26.5%

Northeast region                            0.008693                26.3%
Midwest region                              0.008731                26.5%
Southern region                             0.007925                24.0%
Western region                              0.009952                30.2%

Hispanics                                   0.009658                29.3%
Non-hispanic whites                         0.008593                26.0%
Non-hispanic blacks                         0.007937                24.1%
Non-hisp/non-white/non-black                0.010602                32.1%

All infants (< 1 year)                      0.018891                57.2%
Nursing infants                             0.010595                32.1%
Non-nursing infants                         0.022040                66.8%
Children 1-6  yrs                           0.018682                56.6%
Children 7-12 yrs                           0.010537                31.9%

Females 13-19 (not preg or nursing)         0.006151                18.6%
Females 20+ (not preg or nursing)           0.007503                22.7%
Females 13-50 yrs                           0.007562                22.9%
Females 13+ (preg/not nursing)              0.009275                28.1%
Females 13+ (nursing)                       0.009753                29.6%

Males 13-19 yrs                             0.006920                21.0%
Males 20+ yrs                               0.006899                20.9%
Seniors 55+                                 0.007875                23.9%

Children 1-2 yrs                            0.022497                68.2%
Children 3-5 yrs                            0.017817                54.0%
Children 6-12 yrs                           0.011011                33.4%
Youth 13-19 yrs                             0.006547                19.8%
Adults 20-49 yrs                            0.006943                21.0%
Adults 50+ yrs                              0.007778                23.6%
Females 13-49 yrs                           0.007073                21.4%

-------------------------------------------------------------------------------
