
                 UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
                            WASHINGTON, D.C. 20460

                                                                      OFFICE OF
                                                            CHEMICAL SAFETY AND
                            		POLLUTION PREVENTION


MEMORANDUM

DATE:  	04-AUG-2011

SUBJECT:	Saflufenacil.  Acute and Chronic Aggregate Dietary (Food and Drinking Water) Exposure and Risk Assessment for Tolerances for Residues in/on Imported Coffee, Banana, and Mango.

PC Code:  118203
DP Barcode:  D390923
Decision No.:  442242 
Registration No.:  7969-278
Petition No.:  0E7806
Regulatory Action:  Tolerances With No U.S. Registration
Risk Assessment Type:  Dietary
Case No.:  NA
TXR No.:  NA
CAS No.:  372137-35-4
MRID No.:  NA
40 CFR:  §180.649

FROM:	George F. Kramer, Ph.D., Senior Chemist
            Risk Assessment Branch 1 (RAB1)/Health Effects Division (HED; 7509P)

THROUGH:	David E. Hrdy, Senior Biologist
            Dennis McNeilly, Chemist
            Dietary Exposure Science Advisory Council (DESAC)
            HED (7509P)

                  and

            Dana M. Vogel, Branch Chief
            RAB1/HED (7509P)
            
TO:		George F. Kramer, Ph.D., Risk Assessor
		RAB1/HED (7509P)

            and

      Kathryn Montague/Susan Stanton, PM Team 23
      Registration Division (RD) (7505P)

Executive Summary

Acute and chronic dietary-exposure and risk assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM-FCID[(TM)], Version 2.03) which use food consumption data from the U.S. Department of Agriculture's Continuing Surveys of Food Intakes by Individuals (CSFII) from 1994-1996 and 1998.  These analyses were performed to support a tolerance petition for residues in/on imported coffee, banana, and mango.  

Acute Dietary (Food and Drinking Water) Exposure Results and Characterization

The unrefined acute analysis assumed 100% crop treated (CT), DEEM[(TM)] 7.81 default concentration factors, and tolerance-level residues for all commodities [except for cottonseed; sunflower subgroup 20B; soybean, seed; vegetable, legume, subgroup 6C, pea and bean (except soybean); and rapeseed subgroup 20A  -  see Section II for more details].  The drinking water estimate from the existing U.S. uses was incorporated directly into the dietary assessment using the concentration for ground water generated by the Tier II Pesticide Root Zone Model Ground Water (PRZM GW).  The acute dietary risk estimates (food + water) at the 95[th] percentile are <1% of the acute population-adjusted dose (aPAD) for the general U.S. population and <1% of the aPAD for the most highly exposed population subgroup (all infants (<1 year old)) and are thus below HED's level of concern (<100% aPAD).

Chronic Dietary (Food and Drinking Water) Exposure Results and Characterization

The unrefined chronic analysis assumed 100% CT, DEEM[(TM)] 7.81 default concentration factors, and tolerance-level residues for all commodities [except for cottonseed; sunflower subgroup 20B; soybean, seed; vegetable, legume, subgroup 6C, pea and bean (except soybean); and rapeseed subgroup 20A  -  see Section II for more details].  The drinking water estimate from the existing U.S. uses was incorporated directly into the dietary assessment using the concentration for ground water generated by PRZM GW.  The chronic dietary risk estimates (food + water) 9.2% of the chronic population-adjusted dose (cPAD) for the general U.S. population and 31% of the cPAD for the most highly exposed population subgroup (all infants (<1 year old)) and are thus below HED's level of concern (<100% cPAD).

Cancer Dietary (Food and Drinking Water) Exposure Results and Characterization

Saflufenacil is classified as "not likely carcinogenic to humans."  Therefore, cancer risk is not a concern for this chemical.


I.  Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide.  For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health effects).  This dose is referred to as the PAD.  The PAD is equivalent to point of departure (POD, NOAEL, LOAEL, i.e.) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD.  HED is generally concerned when estimated cancer risk exceeds one in one million.  References which discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site:  "Available Information on Assessing Exposure from Pesticides, A User's Guide," 21-JUN-2000, web link:  http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf; or see SOP 99.6 (20-AUG-1999).

The most recent dietary exposure risk assessment for saflufenacil was conducted by G. Kramer (Memo, 24-MAR-2011, D381976).


II.  Residue Information

Saflufenacil Proposed and Registered Uses:

Saflufenacil is currently registered for use on legume vegetables (crop group 06), the foliage of legume vegetables (crop group 07), cereal grains (crop group 15), forage, fodder, and straw of cereal grains (crop group 16), cottonseed (subgroup 20C), rapeseed (subgroup 20A), and sunflower (subgroup 20B).  BASF has submitted a tolerance petition for residues in/on imported coffee, banana, and mango.  

Residues of Concern:  The nature of the residue in plants, rotational crops, and livestock is adequately understood based on acceptable metabolism studies conducted on corn (preplant application), soybean (preplant and preharvest application), tomato (preplant application), rotational crops, lactating goats, and laying hens.  The HED Residues of Concern Knowledgebase Subcommittee (ROCKS) determined that residues of concern for the tolerance expression and risk assessment in plants consist of saflufenacil, M800H11, and M800H35; and that saflufenacil is the only residue of concern in livestock (Memo, B. Daiss, 1/6/09; D359645).  An additional major metabolite (M800H02) that is not included in the tolerance expression was observed in soybean seed following preharvest (harvest aid) application.  As the structure of M800H02 is closely related to the parent compound and it is the precursor of the regulated metabolite M800H11, RAB1 concludes that M800H02 is a residue of concern for risk-assessment purposes in crops following post-emergence treatment. 

Table 1.  Summary of Metabolites and Degradates to be Included in the Risk Assessment.
Matrix
Residues included in Risk Assessment
Residues included in Tolerance Expression
Plants
Primary Crops (preplant application)
Saflufenacil + M800H11, M800H35
Saflufenacil + M800H11, M800H35

Primary Crops (preharvest application)
Saflufenacil + M800H11, M800H02, M800H35


Rotational Crops
Saflufenacil + M800H11, M800H35

Livestock
Ruminants
Saflufenacil
Saflufenacil

Poultry


Drinking Water
Saflufenacil + M800H01, M800H02, M800H07, M800H08, M800H15, M800H22, Product 8
Not Applicable

Established Tolerances:  Permanent tolerances for "saflufenacil, including its metabolites and degradates, in or on the commodities in the table below.  Compliance with the tolerance levels specified below is to be determined by measuring only the sum of saflufenacil, 2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-4-fluoro-N-[[methyl(1-methylethyl)amino]sulfonyl]benzamide, and its metabolites N-[2-chloro-5-(2,6-dioxo-4-(trifluoromethyl)-3,6-dihydro-1(2H)-pyrimidinyl)-4-fluorobenzoyl]-N'-isopropylsulfamide and N-[4-chloro-2-fluoro-5-({[(isopropylamino)sulfonyl]amino}carbonyl)phenyl]urea, calculated as the stoichiometric equivalent of saflufenacil" are currently established under 40 CFR §180.649(a)(1) for residues on citrus fruit (Crop Group 10), pome fruit (Crop Group 11), stone fruit (Crop Group 12), grape, tree nuts (Crop Group 14), legume vegetables (crop group 06), the foliage of legume vegetables (crop group 07), cereal grains (crop group 15), forage, fodder, and straw of cereal grains (crop group 16), cottonseed (subgroup 20C), rapeseed (subgroup 20A), and sunflower (subgroup 20B).  Additionally, permanent tolerances for "saflufenacil, including its metabolites and degradates, in or on the commodities in the table below.  Compliance with the tolerance levels specified below is to be determined by measuring only saflufenacil, 2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-4-fluoro-N-[[methyl(1-methylethyl)amino]sulfonyl]benzamide" are currently established under 40 CFR §180.649(a)(2) for residues on livestock commodities.

Recommended Tolerances:  Based on the residue chemistry data submitted with the current petition, HED recommended for establishment of the following tolerances (G. Kramer, 04-AUG-2011; D390922):

Table 2.  Tolerance Summary for Saflufenacil.
Commodity
                          Recommended Tolerance (ppm)
Coffee, green bean
                                     0.03 
Banana
                                     0.03
Mango
                                     0.03

Residue Data used for Acute and Chronic Assessments:

The acute and chronic assessments were based on the assumption of tolerance-level residues for all commodities, except for cottonseed; sunflower subgroup 20B; soybean, seed; vegetable, legume, subgroup 6C, pea and bean (except soybean); and rapeseed subgroup 20A.  For these crops, residues were also based on the recommended tolerances; however, a correction factor was applied to the tolerance level to account for the M800H02 metabolite included in the risk assessment as a result of preharvest uses.  The additional metabolite, M800H02, was observed in the metabolism studies of preharvest-treated soybean seed, comprising 26.3% of the total radioactive residues (G. Kramer, 3/24/11; DP# 381129).  Since the toxicity of the M800H02 is expected to be comparable to the parent compound, it was included in the risk assessment for preharvest uses, but not in the tolerance expression.  To account for this additional toxicity exposure, the recommended tolerance level was multiplied by a correction factor of 1.7x, where 1.7 = (Metabolites in Risk Assessment)/(Metabolites in Tolerance Expression).  

1.7 =	(Saflufenacil + M800H11 + M800H02 + M800H35)/(Saflufenacil + M800H11 + M800H35) = 
     (26.1% + 10.9% + 26.3% + 0%)/(26.1% + 10.9% + 0%)

Therefore, in the acute and chronic assessments, a residue of 0.34 ppm was used for cottonseed; a residue of 1.7 ppm was used for sunflower subgroup 20B; a residue of 0.17 ppm was used for soybean, seed; a residue of 0.51 ppm was used for vegetable, legume, subgroup 6C, pea and bean (except soybean); and a residue of 0.76 ppm was used for rapeseed subgroup 20A (see Table 3).

Table 3.  Corrected Residues Used in the Chronic Assessment.
Crop Group and/or Commodity
Tolerance (ppm)[2]
Corrected Residue Used in Dietary Assessments[1]
Cottonseed Subgroup 20C
                                     0.20
                                     0.34
Sunflower Subgroup 20B
                                      1.0
                                      1.7
Soybean, seed
                                     0.10
                                     0.17
Vegetable, Legume, Subgroup 6C, pea and bean (except soybean)
                                     0.30
                                     0.51
Rapeseed Subgroup 20A 
                                     0.45
                                     0.76
[1] Tolerance level residues were corrected to account for the addition of the M800H02 metabolite which was observed in the metabolism studies of preharvest-treated soybean seed.  The recommended tolerance level was multiplied by a correction factor of 1.7x, where 1.7 = (Metabolites in Risk Assessment)/(Metabolites in Tolerance Expression).
[2] These are HED-recommended tolerances based on Petitions 0F7744 and 0F7766.

%CT Information:  The chronic assessment was based on the assumption of 100% CT for all commodities.

Processing Factors:  DEEM[(TM)] 7.81 default processing factors were used for all processed commodities (where provided).


III.  Drinking Water Data

The Estimated Drinking Water Concentrations (EDWCs) used in the dietary exposure risk assessment were provided by the Environmental Fate and Effects Division (EFED) in a memorandum dated 04/15/09 (Memo, G. Orrick; DP# 349860).  Water residues were incorporated directly into the DEEM-FCID[(TM)] into the food categories "water, direct, all sources" and "water, indirect, all sources."

Screening EDWCs (Table 3) of saflufenacil were generated with FQPA Index Reservoir Screening Tool (FIRST) for surface water and with PRZM GW for ground water.  Modeled application rates represent the maximum use patterns of five proposed end-use labels with selected uses on row crops, orchard trees, vineyards, tree plantations, and non-agricultural areas.  Remaining model input parameters were chosen according to current guidance (USEPA, 2002).  EDWCs reflect exposure to saflufenacil and all degradates of concern in drinking water (Table 1).  

Table 3.  Tiered EDWCs for Proposed Saflufenacil Uses.

Source (Tier: Model)
                       1-in-10-year Peak Exposure (ppb)
                    1-in-10-year Annual Mean Exposure (ppb)
Surface water (Tier I: FIRST)
                                     37.3
                                     23.8
Ground water (Tier II: PRZM GW)
                                      180
                           (used in acute analysis)
                                      173
                          (used in chronic analysis)


IV.  DEEM-FCID[(TM)] Program and Consumption Information

Saflufenacil acute and chronic dietary exposure assessments were conducted using DEEM-FCID[(TM)], Version 2.03, which incorporates consumption data from USDA's CSFII, 1994-1996 and 1998.  The 1994-96, 98 data are based on the reported consumption of more than 20,000 individuals over two non-consecutive survey days.  Foods "as consumed" (i.e., apple pie) are linked to EPA-defined food commodities (i.e. apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA.  For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups, but for acute exposure assessment are retained as individual consumption events.  Based on analysis of the 1994-96, 98 CSFII consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1-2 years old, children 3-5 years old, children 6-12 years old, youth 13-19 years old, females 13-49 years old, adults 20-49 years old, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or food-form (i.e., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food form to produce a residue intake estimate.  The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure.  Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD.  This procedure is performed for each population subgroup.

For acute exposure assessments, individual one-day food consumption data are used on an individual-by-individual basis.  The reported consumption amounts of each food item can be multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or "matched" in multiple random pairings with residue values and then summed in a probabilistic assessment.  The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating relevant commodities/food forms) and a per-capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis.  In accordance with HED policy, per capita exposure and risk are reported for all tiers of analysis.  However, for Tiers 1 and 2, any significant differences in user vs. per capita exposure and risk are specifically identified and noted in the risk assessment.


V.  Toxicological Information

Table 4.  Summary of Toxicological Doses and Endpoints for Saflufenacil for Use in Dietary Human-Health Risk Assessments.
Exposure/
Scenario
Point of Departure
Uncertainty/
FQPA SFs
RfD, PAD, LOC for Risk Assessment
Study and Toxicological Effects
Acute Dietary (General Population, including Infants and Children)
NOAEL = 500 mg/kg/day
UFA = 10X
UFH = 10X

FQPA SF = 1X
Acute RfD = 5.0 mg/kg

aPAD = 5.0 mg/kg
Acute Neurotoxicity Study.
NOAEL = 500 (M) and 2000 (F) mg/kg/day.
LOAEL was 2000 mg/kg/day (males) based on the decreased motor activity representing mild and transient systemic toxicity. 
LOAEL was not established for females.
Chronic Dietary (All Populations)
NOAEL = 4.6 mg/kg/day 
UFA = 10X
UFH = 10X

FQPA SF = 1X
Chronic RfD = 0.046 mg/kg/day

cPAD = 0.046 mg/kg/day
Chronic/Carcinogenicity (mouse).
NOAEL = 4.6 mg/kg bw/d (males) and 18.9 mg/kg bw/d (females). 
LOAELs = 13.8 mg/kg bw/d (males) and 38.1 mg/kg bw/day (females) based on decreased red blood cells, hemoglobin, and hematocrit and porphyria observed in the satellite group.
Cancer (oral, dermal, inhalation)
Classification:  Not carcinogenic based on the lack of tumors in the mouse and rat carcinogenicity studies and lack of mutagenicity.
NOAEL = no-observed adverse-effect level.  LOAEL = lowest-observed adverse-effect level.  UF = uncertainty factor.  UFA = extrapolation from animal to human (interspecies).  UFH = potential variation in sensitivity among members of the human population (intraspecies).  FQPA SF = FQPA Safety Factor.  PAD = population-adjusted dose (a = acute, c = chronic).  RfD = reference dose.  LOC = level of concern.


VI.  Results/Discussion 

For acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the PAD.  The DEEM-FCID[(TM)] analyses estimate the dietary exposure of the U.S. population and various population subgroups.  The results reported in Table 3 are for the general U.S. population, all infants (<1 year old), children 1-2 years old, children 3-5 years old, children 6-12 years old, youth 13-19 years old, females 13-49 years old, adults 20-49 years old, and adults 50+ years old. 
 
Results of Acute and Chronic Dietary Exposure Analyses

The acute dietary risk for food and drinking water utilized (<1% of the aPAD for the U.S. population.  The acute dietary risk for the highest exposed population subgroup, all infants (<1 year old), is <1% of the aPAD at the 95[th] percentile.

The chronic dietary risk for food and drinking water utilized 9.2% of the cPAD for the U.S. population.  The chronic dietary risk for the highest exposed population subgroup, all infants (<1 year old), is 31% of the cPAD.  

The results of the acute and chronic dietary exposure analyses are reported in Table 5.  

 Table 5.  Summary of Dietary (Food and Drinking Water) Exposure Risk for Saflufenacil.
                              Population Subgroup
                                 Acute Dietary
                              (95[th] Percentile)
                                Chronic Dietary
                                        
                          Dietary Exposure (mg/kg/day)
                                     % aPAD
                                Dietary Exposure
                                  (mg/kg/day)
                                     % cPAD
 General U.S. Population
                                    0.010415
                                     <1
                                    0.004232
                                      9.2
 All Infants (<1 year old)
                                    0.038388
                                     <1
                                    0.014043
                                       31
 Children 1-2 years old
                                    0.017262
                                     <1
                                    0.007290
                                       16
 Children 3-5 years old
                                    0.015438
                                     <1
                                    0.006535
                                       14
 Children 6-12 years old
                                    0.010471
                                     <1
                                    0.004383
                                       10
 Youth 13-19 years old
                                    0.008451
                                     <1
                                    0.003164
                                      6.9
 Adults 20-49 years old
                                    0.009266
                                     <1
                                    0.003821
                                      8.3
 Adults 50+ years old
                                    0.008388
                                     <1
                                    0.003959
                                      8.6
 Females 13-49 years old
                                    0.009336
                                     <1
                                    0.003802
                                      8.3
 *The values for the highest exposed population for each type of risk assessment are bolded.


 VII.  Characterization of Inputs/Outputs
 
These acute and chronic dietary exposure and risk estimates are conservative since they assumed 100% CT, DEEM[(TM)] 7.81 default concentration factors, and tolerance-level or higher residues and were based on screening level estimates of drinking water concentrations generated by PRZM GW.  They could be further refined through the use of anticipated residues, empirical processing factors and % CT data, as well as refined drinking water estimates.
 
 
 VIII.  Conclusions
 
The acute and chronic dietary exposure and risk analyses using DEEM-FCID[(TM)] indicates that dietary risks to saflufenacil from food and drinking water are well below HED's levels of concern for this pesticide.  Estimated acute dietary risks are <1% of the aPAD at the 95[th] percentile for the general U.S. population and all population subgroups and estimated chronic dietary risks are <=31% of the cPAD for the general U.S. population and all population subgroups.  


 IX.  List of Attachments
 
 Acute Food plus Water Residue Input File.
 Acute Results File.
 Chronic Food plus Water Residue Input File.
 Chronic Results File.























cc:  G. Kramer (RAB1)
RDI:  DESAC (7/18/11)
G.F. Kramer:S10957:PY-S:(703)305-5079:7509P:RAB1
Acute Food plus Water Residue Input File

Filename: C:\Documents and Settings\gkramer\My Documents\Gk\##Saflufenacil-new\0E7806\Saflufenacil_Acute.R98
Chemical: Saflufenacil
RfD(Chronic): .046 mg/kg bw/day  NOEL(Chronic): 0 mg/kg bw/day
RfD(Acute): 5 mg/kg bw/day  NOEL(Acute):  0 mg/kg bw/day
Date created/last modified: 07-14-2011/14:09:07/8          Program ver. 2.03
--------------------------------------------------------------------------------
  EPA    Crop                                   Def Res     Adj.Factors   Comment
  Code    Grp  Commodity Name                    (ppm)       #1    #2   
-------- ---- -------------------------------  ----------  ------ ------  -------
06003470 6    Soybean, seed                      0.170000   1.000  1.000  
06003480 6    Soybean, flour                     0.170000   1.000  1.000  
06003481 6    Soybean, flour-babyfood            0.170000   1.000  1.000  
06003490 6    Soybean, soy milk                  0.170000   1.000  1.000  
06003491 6    Soybean, soy milk-babyfood or in   0.170000   1.000  1.000  
06003500 6    Soybean, oil                       0.170000   1.000  1.000  
06003501 6    Soybean, oil-babyfood              0.170000   1.000  1.000  
06010430 6A   Bean, snap, succulent              0.030000   1.000  1.000  
06010431 6A   Bean, snap, succulent-babyfood     0.030000   1.000  1.000  
06012570 6A   Pea, edible podded, succulent      0.030000   1.000  1.000  
06020310 6B   Bean, broad, succulent             0.030000   1.000  1.000  
06020330 6B   Bean, cowpea, succulent            0.030000   1.000  1.000  
06020370 6B   Bean, lima, succulent              0.030000   1.000  1.000  
06022550 6B   Pea, succulent                     0.030000   1.000  1.000  
06022551 6B   Pea, succulent-babyfood            0.030000   1.000  1.000  
06022590 6B   Pea, pigeon, succulent             0.030000   1.000  1.000  
06030300 6C   Bean, black, seed                  0.510000   1.000  1.000  
06030320 6C   Bean, broad, seed                  0.510000   1.000  1.000  
06030340 6C   Bean, cowpea, seed                 0.510000   1.000  1.000  
06030350 6C   Bean,  great northern, seed        0.510000   1.000  1.000  
06030360 6C   Bean, kidney, seed                 0.510000   1.000  1.000  
06030380 6C   Bean, lima, seed                   0.510000   1.000  1.000  
06030390 6C   Bean, mung, seed                   0.510000   1.000  1.000  
06030400 6C   Bean, navy, seed                   0.510000   1.000  1.000  
06030410 6C   Bean, pink, seed                   0.510000   1.000  1.000  
06030420 6C   Bean, pinto, seed                  0.510000   1.000  1.000  
06030980 6C   Chickpea, seed                     0.510000   1.000  1.000  
06030981 6C   Chickpea, seed-babyfood            0.510000   1.000  1.000  
06030990 6C   Chickpea, flour                    0.510000   1.000  1.000  
06031820 6C   Guar, seed                         0.510000   1.000  1.000  
06031821 6C   Guar, seed-babyfood                0.510000   1.000  1.000  
06032030 6C   Lentil, seed                       0.510000   1.000  1.000  
06032560 6C   Pea, dry                           0.510000   1.000  1.000  
06032561 6C   Pea, dry-babyfood                  0.510000   1.000  1.000  
06032580 6C   Pea, pigeon, seed                  0.510000   1.000  1.000  
10001060 10   Citrus citron                      0.030000   1.000  1.000  
10001070 10   Citrus hybrids                     0.030000   1.000  1.000  
10001080 10   Citrus, oil                        0.030000   1.000  1.000  
10001800 10   Grapefruit                         0.030000   1.000  1.000  
10001810 10   Grapefruit, juice                  0.030000   2.100  1.000  
10001970 10   Kumquat                            0.030000   1.000  1.000  
10001990 10   Lemon                              0.030000   1.000  1.000  
10002000 10   Lemon, juice                       0.030000   2.000  1.000  
10002001 10   Lemon, juice-babyfood              0.030000   2.000  1.000  
10002010 10   Lemon, peel                        0.030000   1.000  1.000  
10002060 10   Lime                               0.030000   1.000  1.000  
10002070 10   Lime, juice                        0.030000   2.000  1.000  
10002071 10   Lime, juice-babyfood               0.030000   2.000  1.000  
10002400 10   Orange                             0.030000   1.000  1.000  
10002410 10   Orange, juice                      0.030000   1.800  1.000  
10002411 10   Orange, juice-babyfood             0.030000   1.800  1.000  
10002420 10   Orange, peel                       0.030000   1.000  1.000  
10003070 10   Pummelo                            0.030000   1.000  1.000  
10003690 10   Tangerine                          0.030000   1.000  1.000  
10003700 10   Tangerine, juice                   0.030000   1.000  1.000  
11000070 11   Apple, fruit with peel             0.030000   1.000  1.000  
11000080 11   Apple, peeled fruit                0.030000   1.000  1.000  
11000081 11   Apple, peeled fruit-babyfood       0.030000   1.000  1.000  
11000090 11   Apple, dried                       0.030000   8.000  1.000  
11000091 11   Apple, dried-babyfood              0.030000   8.000  1.000  
11000100 11   Apple, juice                       0.030000   1.300  1.000  
11000101 11   Apple, juice-babyfood              0.030000   1.300  1.000  
11000110 11   Apple, sauce                       0.030000   1.000  1.000  
11000111 11   Apple, sauce-babyfood              0.030000   1.000  1.000  
11001290 11   Crabapple                          0.030000   1.000  1.000  
11002100 11   Loquat                             0.030000   1.000  1.000  
11002660 11   Pear                               0.030000   1.000  1.000  
11002661 11   Pear-babyfood                      0.030000   1.000  1.000  
11002670 11   Pear, dried                        0.030000   6.250  1.000  
11002680 11   Pear, juice                        0.030000   1.000  1.000  
11002681 11   Pear, juice-babyfood               0.030000   1.000  1.000  
11003100 11   Quince                             0.030000   1.000  1.000  
12000120 12   Apricot                            0.030000   1.000  1.000  
12000121 12   Apricot-babyfood                   0.030000   1.000  1.000  
12000130 12   Apricot, dried                     0.030000   6.000  1.000  
12000140 12   Apricot, juice                     0.030000   1.000  1.000  
12000141 12   Apricot, juice-babyfood            0.030000   1.000  1.000  
12000900 12   Cherry                             0.030000   1.000  1.000  
12000901 12   Cherry-babyfood                    0.030000   1.000  1.000  
12000910 12   Cherry, juice                      0.030000   1.500  1.000  
12000911 12   Cherry, juice-babyfood             0.030000   1.500  1.000  
12002300 12   Nectarine                          0.030000   1.000  1.000  
12002600 12   Peach                              0.030000   1.000  1.000  
12002601 12   Peach-babyfood                     0.030000   1.000  1.000  
12002610 12   Peach, dried                       0.030000   7.000  1.000  
12002611 12   Peach, dried-babyfood              0.030000   7.000  1.000  
12002620 12   Peach, juice                       0.030000   1.500  1.000  
12002621 12   Peach, juice-babyfood              0.030000   1.500  1.000  
12002850 12   Plum                               0.030000   1.000  1.000  
12002851 12   Plum-babyfood                      0.030000   1.000  1.000  
12002860 12   Plum, prune, fresh                 0.030000   1.000  1.000  
12002861 12   Plum, prune, fresh-babyfood        0.030000   1.000  1.000  
12002870 12   Plum, prune, dried                 0.030000   5.000  1.000  
12002871 12   Plum, prune, dried-babyfood        0.030000   5.000  1.000  
12002880 12   Plum, prune, juice                 0.030000   1.400  1.000  
12002881 12   Plum, prune, juice-babyfood        0.030000   1.400  1.000  
14000030 14   Almond                             0.030000   1.000  1.000  
14000031 14   Almond-babyfood                    0.030000   1.000  1.000  
14000040 14   Almond, oil                        0.030000   1.000  1.000  
14000041 14   Almond, oil-babyfood               0.030000   1.000  1.000  
14000590 14   Brazil nut                         0.030000   1.000  1.000  
14000680 14   Butternut                          0.030000   1.000  1.000  
14000810 14   Cashew                             0.030000   1.000  1.000  
14000920 14   Chestnut                           0.030000   1.000  1.000  
14001550 14   Filbert                            0.030000   1.000  1.000  
14001560 14   Filbert, oil                       0.030000   1.000  1.000  
14001850 14   Hickory nut                        0.030000   1.000  1.000  
14002130 14   Macadamia nut                      0.030000   1.000  1.000  
14002690 14   Pecan                              0.030000   1.000  1.000  
14002820 14   Pistachio                          0.030000   1.000  1.000  
14003910 14   Walnut                             0.030000   1.000  1.000  
15000250 15   Barley, pearled barley             0.030000   1.000  1.000  
15000251 15   Barley, pearled barley-babyfood    0.030000   1.000  1.000  
15000260 15   Barley, flour                      0.030000   1.000  1.000  
15000261 15   Barley, flour-babyfood             0.030000   1.000  1.000  
15000270 15   Barley, bran                       0.030000   1.000  1.000  
15000650 15   Buckwheat                          0.030000   1.000  1.000  
15000660 15   Buckwheat, flour                   0.030000   1.000  1.000  
15001200 15   Corn, field, flour                 0.030000   1.000  1.000  
15001201 15   Corn, field, flour-babyfood        0.030000   1.000  1.000  
15001210 15   Corn, field, meal                  0.030000   1.000  1.000  
15001211 15   Corn, field, meal-babyfood         0.030000   1.000  1.000  
15001220 15   Corn, field, bran                  0.030000   1.000  1.000  
15001230 15   Corn, field, starch                0.030000   1.000  1.000  
15001231 15   Corn, field, starch-babyfood       0.030000   1.000  1.000  
15001240 15   Corn, field, syrup                 0.030000   1.500  1.000  
15001241 15   Corn, field, syrup-babyfood        0.030000   1.500  1.000  
15001250 15   Corn, field, oil                   0.030000   1.000  1.000  
15001251 15   Corn, field, oil-babyfood          0.030000   1.000  1.000  
15001260 15   Corn, pop                          0.030000   1.000  1.000  
15001270 15   Corn, sweet                        0.030000   1.000  1.000  
15001271 15   Corn, sweet-babyfood               0.030000   1.000  1.000  
15002260 15   Millet, grain                      0.030000   1.000  1.000  
15002310 15   Oat, bran                          0.030000   1.000  1.000  
15002320 15   Oat, flour                         0.030000   1.000  1.000  
15002321 15   Oat, flour-babyfood                0.030000   1.000  1.000  
15002330 15   Oat, groats/rolled oats            0.030000   1.000  1.000  
15002331 15   Oat, groats/rolled oats-babyfood   0.030000   1.000  1.000  
15003230 15   Rice, white                        0.030000   1.000  1.000  
15003231 15   Rice, white-babyfood               0.030000   1.000  1.000  
15003240 15   Rice, brown                        0.030000   1.000  1.000  
15003241 15   Rice, brown-babyfood               0.030000   1.000  1.000  
15003250 15   Rice, flour                        0.030000   1.000  1.000  
15003251 15   Rice, flour-babyfood               0.030000   1.000  1.000  
15003260 15   Rice, bran                         0.030000   1.000  1.000  
15003261 15   Rice, bran-babyfood                0.030000   1.000  1.000  
15003280 15   Rye, grain                         0.030000   1.000  1.000  
15003290 15   Rye, flour                         0.030000   1.000  1.000  
15003440 15   Sorghum, grain                     0.030000   1.000  1.000  
15003450 15   Sorghum, syrup                     0.030000   1.000  1.000  
15003810 15   Triticale, flour                   0.030000   1.000  1.000  
15003811 15   Triticale, flour-babyfood          0.030000   1.000  1.000  
15004010 15   Wheat, grain                       0.030000   1.000  1.000  
15004011 15   Wheat, grain-babyfood              0.030000   1.000  1.000  
15004020 15   Wheat, flour                       0.030000   1.000  1.000  
15004021 15   Wheat, flour-babyfood              0.030000   1.000  1.000  
15004030 15   Wheat, germ                        0.030000   1.000  1.000  
15004040 15   Wheat, bran                        0.030000   1.000  1.000  
15004050 15   Wild rice                          0.030000   1.000  1.000  
20001630 20   Flaxseed, oil                      0.760000   1.000  1.000  
20003190 20   Rapeseed, oil                      0.760000   1.000  1.000  
20003191 20   Rapeseed, oil-babyfood             0.760000   1.000  1.000  
20003300 20   Safflower, oil                     1.700000   1.000  1.000  
20003301 20   Safflower, oil-babyfood            1.700000   1.000  1.000  
20003640 20   Sunflower, seed                    1.700000   1.000  1.000  
20003650 20   Sunflower, oil                     1.700000   1.000  1.000  
20003651 20   Sunflower, oil-babyfood            1.700000   1.000  1.000  
21000440 M    Beef, meat                         0.010000   1.000  1.000  
21000441 M    Beef, meat-babyfood                0.010000   1.000  1.000  
21000450 M    Beef, meat, dried                  0.010000   1.920  1.000  
21000460 M    Beef, meat byproducts              0.050000   1.000  1.000  
21000461 M    Beef, meat byproducts-babyfood     0.050000   1.000  1.000  
21000470 M    Beef, fat                          0.010000   1.000  1.000  
21000471 M    Beef,fat-babyfood                  0.010000   1.000  1.000  
21000480 M    Beef, kidney                       0.050000   1.000  1.000  
21000490 M    Beef, liver                        2.500000   1.000  1.000  
21000491 M    Beef, liver-babyfood               2.500000   1.000  1.000  
23001690 M    Goat, meat                         0.010000   1.000  1.000  
23001700 M    Goat, meat byproducts              0.050000   1.000  1.000  
23001710 M    Goat, fat                          0.010000   1.000  1.000  
23001720 M    Goat, kidney                       0.050000   1.000  1.000  
23001730 M    Goat, liver                        2.500000   1.000  1.000  
24001890 M    Horse, meat                        0.010000   1.000  1.000  
25002900 M    Pork, meat                         0.010000   1.000  1.000  
25002901 M    Pork, meat-babyfood                0.010000   1.000  1.000  
25002910 M    Pork, skin                         0.010000   1.000  1.000  
25002920 M    Pork, meat byproducts              0.020000   1.000  1.000  
25002921 M    Pork, meat byproducts-babyfood     0.020000   1.000  1.000  
25002930 M    Pork, fat                          0.010000   1.000  1.000  
25002931 M    Pork, fat-babyfood                 0.010000   1.000  1.000  
25002940 M    Pork, kidney                       0.010000   1.000  1.000  
25002950 M    Pork, liver                        0.800000   1.000  1.000  
26003390 M    Sheep, meat                        0.010000   1.000  1.000  
26003391 M    Sheep, meat-babyfood               0.010000   1.000  1.000  
26003400 M    Sheep, meat byproducts             0.050000   1.000  1.000  
26003410 M    Sheep, fat                         0.010000   1.000  1.000  
26003411 M    Sheep, fat-babyfood                0.010000   1.000  1.000  
26003420 M    Sheep, kidney                      0.050000   1.000  1.000  
26003430 M    Sheep, liver                       2.500000   1.000  1.000  
27002220 D    Milk, fat                          0.010000   1.000  1.000  
27002221 D    Milk, fat - baby food/infant for   0.010000   1.000  1.000  
27012230 D    Milk, nonfat solids                0.010000   1.000  1.000  
27012231 D    Milk, nonfat solids-baby food/in   0.010000   1.000  1.000  
27022240 D    Milk, water                        0.010000   1.000  1.000  
27022241 D    Milk, water-babyfood/infant form   0.010000   1.000  1.000  
27032251 D    Milk, sugar (lactose)-baby food/   0.010000   1.000  1.000  
29003120 M    Rabbit, meat                       0.010000   1.000  1.000  
86010000 O    Water, direct, all sources         0.180000   1.000  1.000  
86020000 O    Water, indirect, all sources       0.180000   1.000  1.000  
95000230 O    Banana                             0.030000   1.000  1.000  
95000231 O    Banana-babyfood                    0.030000   1.000  1.000  
95000240 O    Banana, dried                      0.030000   3.900  1.000  
95000241 O    Banana, dried-babyfood             0.030000   3.900  1.000  
95001150 O    Coffee, roasted bean               0.030000   1.000  1.000  
95001160 O    Coffee, instant                    0.030000   1.000  1.000  
95001280 O    Cottonseed, oil                    0.340000   1.000  1.000  
95001281 O    Cottonseed, oil-babyfood           0.340000   1.000  1.000  
95001750 O    Grape                              0.030000   1.000  1.000  
95001760 O    Grape, juice                       0.030000   1.200  1.000  
95001761 O    Grape, juice-babyfood              0.030000   1.200  1.000  
95001770 O    Grape, leaves                      0.030000   1.000  1.000  
95001780 O    Grape, raisin                      0.030000   4.300  1.000  
95001790 O    Grape, wine and sherry             0.030000   1.000  1.000  
95002150 O    Mango                              0.030000   1.000  1.000  
95002160 O    Mango, dried                       0.030000   1.000  1.000  
95002170 O    Mango, juice                       0.030000   1.000  1.000  
95002171 O    Mango, juice-babyfood              0.030000   1.000  1.000  
95003360 O    Sesame, seed                       0.760000   1.000  1.000  
95003361 O    Sesame, seed-babyfood              0.760000   1.000  1.000  
95003370 O    Sesame, oil                        0.760000   1.000  1.000  
95003371 O    Sesame, oil-babyfood               0.760000   1.000  1.000  

 Acute Results File.
U.S. Environmental Protection Agency                                  Ver. 2.02
DEEM-FCID ACUTE Analysis for SAFLUFENACIL                        (1994-98 data)
Residue file: Saflufenacil_Acute.R98                  Adjustment factor #2 used.
Analysis Date: 07-14-2011/15:27:20    Residue file dated: 07-14-2011/14:09:07/8
Daily totals for food and foodform consumption used.
Run Comment: ""
===============================================================================

Summary calculations (per capita):

                    95th Percentile      99th Percentile      99.9th Percentile
                   Exposure   % aRfD    Exposure   % aRfD    Exposure   % aRfD 
                  ---------- --------  ---------- --------  ---------- --------
U.S. Population:
                    0.010415     0.21    0.019031     0.38    0.037230     0.74 
All infants:
                    0.038388     0.77    0.054734     1.09    0.095501     1.91 
Children 1-2 yrs:
                    0.017262     0.35    0.028555     0.57    0.040967     0.82 
Children 3-5 yrs:
                    0.015438     0.31    0.023025     0.46    0.039569     0.79 
Children 6-12 yrs:
                    0.010471     0.21    0.017194     0.34    0.026015     0.52 
Youth 13-19 yrs:
                    0.008451     0.17    0.013822     0.28    0.023396     0.47 
Adults 20-49 yrs:
                    0.009266     0.19    0.015264     0.31    0.027095     0.54 
Adults 50+ yrs:
                    0.008388     0.17    0.011916     0.24    0.019613     0.39 
Females 13-49 yrs:
                    0.009336     0.19    0.014984     0.30    0.025487     0.51 

Chronic Food plus Water Residue Input File.

Filename: C:\Documents and Settings\gkramer\My Documents\Gk\##Saflufenacil-new\0E7806\Saflufenacil_Chronic.R98
Chemical: Saflufenacil
RfD(Chronic): .046 mg/kg bw/day  NOEL(Chronic): 0 mg/kg bw/day
RfD(Acute): 5 mg/kg bw/day  NOEL(Acute):  0 mg/kg bw/day
Date created/last modified: 03-18-2011/10:48:46/8          Program ver. 2.03
--------------------------------------------------------------------------------
  EPA    Crop                                   Def Res     Adj.Factors   Comment
  Code    Grp  Commodity Name                    (ppm)       #1    #2   
-------- ---- -------------------------------  ----------  ------ ------  -------
06003470 6    Soybean, seed                      0.170000   1.000  1.000  
06003480 6    Soybean, flour                     0.170000   1.000  1.000  
06003481 6    Soybean, flour-babyfood            0.170000   1.000  1.000  
06003490 6    Soybean, soy milk                  0.170000   1.000  1.000  
06003491 6    Soybean, soy milk-babyfood or in   0.170000   1.000  1.000  
06003500 6    Soybean, oil                       0.170000   1.000  1.000  
06003501 6    Soybean, oil-babyfood              0.170000   1.000  1.000  
06010430 6A   Bean, snap, succulent              0.030000   1.000  1.000  
06010431 6A   Bean, snap, succulent-babyfood     0.030000   1.000  1.000  
06012570 6A   Pea, edible podded, succulent      0.030000   1.000  1.000  
06020310 6B   Bean, broad, succulent             0.030000   1.000  1.000  
06020330 6B   Bean, cowpea, succulent            0.030000   1.000  1.000  
06020370 6B   Bean, lima, succulent              0.030000   1.000  1.000  
06022550 6B   Pea, succulent                     0.030000   1.000  1.000  
06022551 6B   Pea, succulent-babyfood            0.030000   1.000  1.000  
06022590 6B   Pea, pigeon, succulent             0.030000   1.000  1.000  
06030300 6C   Bean, black, seed                  0.510000   1.000  1.000  
06030320 6C   Bean, broad, seed                  0.510000   1.000  1.000  
06030340 6C   Bean, cowpea, seed                 0.510000   1.000  1.000  
06030350 6C   Bean,  great northern, seed        0.510000   1.000  1.000  
06030360 6C   Bean, kidney, seed                 0.510000   1.000  1.000  
06030380 6C   Bean, lima, seed                   0.510000   1.000  1.000  
06030390 6C   Bean, mung, seed                   0.510000   1.000  1.000  
06030400 6C   Bean, navy, seed                   0.510000   1.000  1.000  
06030410 6C   Bean, pink, seed                   0.510000   1.000  1.000  
06030420 6C   Bean, pinto, seed                  0.510000   1.000  1.000  
06030980 6C   Chickpea, seed                     0.510000   1.000  1.000  
06030981 6C   Chickpea, seed-babyfood            0.510000   1.000  1.000  
06030990 6C   Chickpea, flour                    0.510000   1.000  1.000  
06031820 6C   Guar, seed                         0.510000   1.000  1.000  
06031821 6C   Guar, seed-babyfood                0.510000   1.000  1.000  
06032030 6C   Lentil, seed                       0.510000   1.000  1.000  
06032560 6C   Pea, dry                           0.510000   1.000  1.000  
06032561 6C   Pea, dry-babyfood                  0.510000   1.000  1.000  
06032580 6C   Pea, pigeon, seed                  0.510000   1.000  1.000  
10001060 10   Citrus citron                      0.030000   1.000  1.000  
10001070 10   Citrus hybrids                     0.030000   1.000  1.000  
10001080 10   Citrus, oil                        0.030000   1.000  1.000  
10001800 10   Grapefruit                         0.030000   1.000  1.000  
10001810 10   Grapefruit, juice                  0.030000   2.100  1.000  
10001970 10   Kumquat                            0.030000   1.000  1.000  
10001990 10   Lemon                              0.030000   1.000  1.000  
10002000 10   Lemon, juice                       0.030000   2.000  1.000  
10002001 10   Lemon, juice-babyfood              0.030000   2.000  1.000  
10002010 10   Lemon, peel                        0.030000   1.000  1.000  
10002060 10   Lime                               0.030000   1.000  1.000  
10002070 10   Lime, juice                        0.030000   2.000  1.000  
10002071 10   Lime, juice-babyfood               0.030000   2.000  1.000  
10002400 10   Orange                             0.030000   1.000  1.000  
10002410 10   Orange, juice                      0.030000   1.800  1.000  
10002411 10   Orange, juice-babyfood             0.030000   1.800  1.000  
10002420 10   Orange, peel                       0.030000   1.000  1.000  
10003070 10   Pummelo                            0.030000   1.000  1.000  
10003690 10   Tangerine                          0.030000   1.000  1.000  
10003700 10   Tangerine, juice                   0.030000   1.000  1.000  
11000070 11   Apple, fruit with peel             0.030000   1.000  1.000  
11000080 11   Apple, peeled fruit                0.030000   1.000  1.000  
11000081 11   Apple, peeled fruit-babyfood       0.030000   1.000  1.000  
11000090 11   Apple, dried                       0.030000   8.000  1.000  
11000091 11   Apple, dried-babyfood              0.030000   8.000  1.000  
11000100 11   Apple, juice                       0.030000   1.300  1.000  
11000101 11   Apple, juice-babyfood              0.030000   1.300  1.000  
11000110 11   Apple, sauce                       0.030000   1.000  1.000  
11000111 11   Apple, sauce-babyfood              0.030000   1.000  1.000  
11001290 11   Crabapple                          0.030000   1.000  1.000  
11002100 11   Loquat                             0.030000   1.000  1.000  
11002660 11   Pear                               0.030000   1.000  1.000  
11002661 11   Pear-babyfood                      0.030000   1.000  1.000  
11002670 11   Pear, dried                        0.030000   6.250  1.000  
11002680 11   Pear, juice                        0.030000   1.000  1.000  
11002681 11   Pear, juice-babyfood               0.030000   1.000  1.000  
11003100 11   Quince                             0.030000   1.000  1.000  
12000120 12   Apricot                            0.030000   1.000  1.000  
12000121 12   Apricot-babyfood                   0.030000   1.000  1.000  
12000130 12   Apricot, dried                     0.030000   6.000  1.000  
12000140 12   Apricot, juice                     0.030000   1.000  1.000  
12000141 12   Apricot, juice-babyfood            0.030000   1.000  1.000  
12000900 12   Cherry                             0.030000   1.000  1.000  
12000901 12   Cherry-babyfood                    0.030000   1.000  1.000  
12000910 12   Cherry, juice                      0.030000   1.500  1.000  
12000911 12   Cherry, juice-babyfood             0.030000   1.500  1.000  
12002300 12   Nectarine                          0.030000   1.000  1.000  
12002600 12   Peach                              0.030000   1.000  1.000  
12002601 12   Peach-babyfood                     0.030000   1.000  1.000  
12002610 12   Peach, dried                       0.030000   7.000  1.000  
12002611 12   Peach, dried-babyfood              0.030000   7.000  1.000  
12002620 12   Peach, juice                       0.030000   1.500  1.000  
12002621 12   Peach, juice-babyfood              0.030000   1.500  1.000  
12002850 12   Plum                               0.030000   1.000  1.000  
12002851 12   Plum-babyfood                      0.030000   1.000  1.000  
12002860 12   Plum, prune, fresh                 0.030000   1.000  1.000  
12002861 12   Plum, prune, fresh-babyfood        0.030000   1.000  1.000  
12002870 12   Plum, prune, dried                 0.030000   5.000  1.000  
12002871 12   Plum, prune, dried-babyfood        0.030000   5.000  1.000  
12002880 12   Plum, prune, juice                 0.030000   1.400  1.000  
12002881 12   Plum, prune, juice-babyfood        0.030000   1.400  1.000  
14000030 14   Almond                             0.030000   1.000  1.000  
14000031 14   Almond-babyfood                    0.030000   1.000  1.000  
14000040 14   Almond, oil                        0.030000   1.000  1.000  
14000041 14   Almond, oil-babyfood               0.030000   1.000  1.000  
14000590 14   Brazil nut                         0.030000   1.000  1.000  
14000680 14   Butternut                          0.030000   1.000  1.000  
14000810 14   Cashew                             0.030000   1.000  1.000  
14000920 14   Chestnut                           0.030000   1.000  1.000  
14001550 14   Filbert                            0.030000   1.000  1.000  
14001560 14   Filbert, oil                       0.030000   1.000  1.000  
14001850 14   Hickory nut                        0.030000   1.000  1.000  
14002130 14   Macadamia nut                      0.030000   1.000  1.000  
14002690 14   Pecan                              0.030000   1.000  1.000  
14002820 14   Pistachio                          0.030000   1.000  1.000  
14003910 14   Walnut                             0.030000   1.000  1.000  
15000250 15   Barley, pearled barley             0.030000   1.000  1.000  
15000251 15   Barley, pearled barley-babyfood    0.030000   1.000  1.000  
15000260 15   Barley, flour                      0.030000   1.000  1.000  
15000261 15   Barley, flour-babyfood             0.030000   1.000  1.000  
15000270 15   Barley, bran                       0.030000   1.000  1.000  
15000650 15   Buckwheat                          0.030000   1.000  1.000  
15000660 15   Buckwheat, flour                   0.030000   1.000  1.000  
15001200 15   Corn, field, flour                 0.030000   1.000  1.000  
15001201 15   Corn, field, flour-babyfood        0.030000   1.000  1.000  
15001210 15   Corn, field, meal                  0.030000   1.000  1.000  
15001211 15   Corn, field, meal-babyfood         0.030000   1.000  1.000  
15001220 15   Corn, field, bran                  0.030000   1.000  1.000  
15001230 15   Corn, field, starch                0.030000   1.000  1.000  
15001231 15   Corn, field, starch-babyfood       0.030000   1.000  1.000  
15001240 15   Corn, field, syrup                 0.030000   1.500  1.000  
15001241 15   Corn, field, syrup-babyfood        0.030000   1.500  1.000  
15001250 15   Corn, field, oil                   0.030000   1.000  1.000  
15001251 15   Corn, field, oil-babyfood          0.030000   1.000  1.000  
15001260 15   Corn, pop                          0.030000   1.000  1.000  
15001270 15   Corn, sweet                        0.030000   1.000  1.000  
15001271 15   Corn, sweet-babyfood               0.030000   1.000  1.000  
15002260 15   Millet, grain                      0.030000   1.000  1.000  
15002310 15   Oat, bran                          0.030000   1.000  1.000  
15002320 15   Oat, flour                         0.030000   1.000  1.000  
15002321 15   Oat, flour-babyfood                0.030000   1.000  1.000  
15002330 15   Oat, groats/rolled oats            0.030000   1.000  1.000  
15002331 15   Oat, groats/rolled oats-babyfood   0.030000   1.000  1.000  
15003230 15   Rice, white                        0.030000   1.000  1.000  
15003231 15   Rice, white-babyfood               0.030000   1.000  1.000  
15003240 15   Rice, brown                        0.030000   1.000  1.000  
15003241 15   Rice, brown-babyfood               0.030000   1.000  1.000  
15003250 15   Rice, flour                        0.030000   1.000  1.000  
15003251 15   Rice, flour-babyfood               0.030000   1.000  1.000  
15003260 15   Rice, bran                         0.030000   1.000  1.000  
15003261 15   Rice, bran-babyfood                0.030000   1.000  1.000  
15003280 15   Rye, grain                         0.030000   1.000  1.000  
15003290 15   Rye, flour                         0.030000   1.000  1.000  
15003440 15   Sorghum, grain                     0.030000   1.000  1.000  
15003450 15   Sorghum, syrup                     0.030000   1.000  1.000  
15003810 15   Triticale, flour                   0.030000   1.000  1.000  
15003811 15   Triticale, flour-babyfood          0.030000   1.000  1.000  
15004010 15   Wheat, grain                       0.030000   1.000  1.000  
15004011 15   Wheat, grain-babyfood              0.030000   1.000  1.000  
15004020 15   Wheat, flour                       0.030000   1.000  1.000  
15004021 15   Wheat, flour-babyfood              0.030000   1.000  1.000  
15004030 15   Wheat, germ                        0.030000   1.000  1.000  
15004040 15   Wheat, bran                        0.030000   1.000  1.000  
15004050 15   Wild rice                          0.030000   1.000  1.000  
20001630 20   Flaxseed, oil                      0.760000   1.000  1.000  
20003190 20   Rapeseed, oil                      0.760000   1.000  1.000  
20003191 20   Rapeseed, oil-babyfood             0.760000   1.000  1.000  
20003300 20   Safflower, oil                     1.700000   1.000  1.000  
20003301 20   Safflower, oil-babyfood            1.700000   1.000  1.000  
20003640 20   Sunflower, seed                    1.700000   1.000  1.000  
20003650 20   Sunflower, oil                     1.700000   1.000  1.000  
20003651 20   Sunflower, oil-babyfood            1.700000   1.000  1.000  
21000440 M    Beef, meat                         0.010000   1.000  1.000  
21000441 M    Beef, meat-babyfood                0.010000   1.000  1.000  
21000450 M    Beef, meat, dried                  0.010000   1.920  1.000  
21000460 M    Beef, meat byproducts              0.050000   1.000  1.000  
21000461 M    Beef, meat byproducts-babyfood     0.050000   1.000  1.000  
21000470 M    Beef, fat                          0.010000   1.000  1.000  
21000471 M    Beef,fat-babyfood                  0.010000   1.000  1.000  
21000480 M    Beef, kidney                       0.050000   1.000  1.000  
21000490 M    Beef, liver                        2.500000   1.000  1.000  
21000491 M    Beef, liver-babyfood               2.500000   1.000  1.000  
23001690 M    Goat, meat                         0.010000   1.000  1.000  
23001700 M    Goat, meat byproducts              0.050000   1.000  1.000  
23001710 M    Goat, fat                          0.010000   1.000  1.000  
23001720 M    Goat, kidney                       0.050000   1.000  1.000  
23001730 M    Goat, liver                        2.500000   1.000  1.000  
24001890 M    Horse, meat                        0.010000   1.000  1.000  
25002900 M    Pork, meat                         0.010000   1.000  1.000  
25002901 M    Pork, meat-babyfood                0.010000   1.000  1.000  
25002910 M    Pork, skin                         0.010000   1.000  1.000  
25002920 M    Pork, meat byproducts              0.020000   1.000  1.000  
25002921 M    Pork, meat byproducts-babyfood     0.020000   1.000  1.000  
25002930 M    Pork, fat                          0.010000   1.000  1.000  
25002931 M    Pork, fat-babyfood                 0.010000   1.000  1.000  
25002940 M    Pork, kidney                       0.010000   1.000  1.000  
25002950 M    Pork, liver                        0.800000   1.000  1.000  
26003390 M    Sheep, meat                        0.010000   1.000  1.000  
26003391 M    Sheep, meat-babyfood               0.010000   1.000  1.000  
26003400 M    Sheep, meat byproducts             0.050000   1.000  1.000  
26003410 M    Sheep, fat                         0.010000   1.000  1.000  
26003411 M    Sheep, fat-babyfood                0.010000   1.000  1.000  
26003420 M    Sheep, kidney                      0.050000   1.000  1.000  
26003430 M    Sheep, liver                       2.500000   1.000  1.000  
27002220 D    Milk, fat                          0.010000   1.000  1.000  
27002221 D    Milk, fat - baby food/infant for   0.010000   1.000  1.000  
27012230 D    Milk, nonfat solids                0.010000   1.000  1.000  
27012231 D    Milk, nonfat solids-baby food/in   0.010000   1.000  1.000  
27022240 D    Milk, water                        0.010000   1.000  1.000  
27022241 D    Milk, water-babyfood/infant form   0.010000   1.000  1.000  
27032251 D    Milk, sugar (lactose)-baby food/   0.010000   1.000  1.000  
29003120 M    Rabbit, meat                       0.010000   1.000  1.000  
86010000 O    Water, direct, all sources         0.173000   1.000  1.000  
86020000 O    Water, indirect, all sources       0.173000   1.000  1.000  
95000230 O    Banana                             0.030000   1.000  1.000  
95000231 O    Banana-babyfood                    0.030000   1.000  1.000  
95000240 O    Banana, dried                      0.030000   3.900  1.000  
95000241 O    Banana, dried-babyfood             0.030000   3.900  1.000  
95001150 O    Coffee, roasted bean               0.030000   1.000  1.000  
95001160 O    Coffee, instant                    0.030000   1.000  1.000  
95001280 O    Cottonseed, oil                    0.340000   1.000  1.000  
95001281 O    Cottonseed, oil-babyfood           0.340000   1.000  1.000  
95001750 O    Grape                              0.030000   1.000  1.000  
95001760 O    Grape, juice                       0.030000   1.200  1.000  
95001761 O    Grape, juice-babyfood              0.030000   1.200  1.000  
95001770 O    Grape, leaves                      0.030000   1.000  1.000  
95001780 O    Grape, raisin                      0.030000   4.300  1.000  
95001790 O    Grape, wine and sherry             0.030000   1.000  1.000  
95002150 O    Mango                              0.030000   1.000  1.000  
95002160 O    Mango, dried                       0.030000   1.000  1.000  
95002170 O    Mango, juice                       0.030000   1.000  1.000  
95002171 O    Mango, juice-babyfood              0.030000   1.000  1.000  
95003360 O    Sesame, seed                       0.760000   1.000  1.000  
95003361 O    Sesame, seed-babyfood              0.760000   1.000  1.000  
95003370 O    Sesame, oil                        0.760000   1.000  1.000  
95003371 O    Sesame, oil-babyfood               0.760000   1.000  1.000  

Chronic Results File.
 
.S. Environmental Protection Agency                                 Ver. 2.00
DEEM-FCID Chronic analysis for SAFLUFENACIL                     (1994-98 data)
Residue file name: C:\Documents and Settings\gkramer\My Documents\Gk\##Saflufenacil-new\0E7806\Saflufenacil_Chronic.R98
                                                     Adjustment factor #2 used.
Analysis Date 07-14-2011/14:09:51     Residue file dated: 07-14-2011/14:07:35/8
Reference dose (RfD, Chronic) = .046 mg/kg bw/day
===============================================================================
                    Total exposure by population subgroup
-------------------------------------------------------------------------------

                                                    Total Exposure
                                         -----------------------------------
          Population                         mg/kg               Percent of 
           Subgroup                       body wt/day                Rfd    
--------------------------------------   -------------       ---------------
U.S. Population (total)                     0.004232                 9.2%

U.S. Population (spring season)             0.004195                 9.1%
U.S. Population (summer season)             0.004498                 9.8%
U.S. Population (autumn season)             0.004115                 8.9%
U.S. Population (winter season)             0.004116                 8.9%

Northeast region                            0.003915                 8.5%
Midwest region                              0.004270                 9.3%
Southern region                             0.004020                 8.7%
Western region                              0.004814                10.5%

Hispanics                                   0.004896                10.6%
Non-hispanic whites                         0.004107                 8.9%
Non-hispanic blacks                         0.004075                 8.9%
Non-hisp/non-white/non-black                0.005158                11.2%

All infants (< 1 year)                      0.014043                30.5%
Nursing infants                             0.005194                11.3%
Non-nursing infants                         0.017401                37.8%
Children 1-6  yrs                           0.006649                14.5%
Children 7-12 yrs                           0.004146                 9.0%

Females 13-19 (not preg or nursing)         0.003045                 6.6%
Females 20+ (not preg or nursing)           0.004018                 8.7%
Females 13-50 yrs                           0.003997                 8.7%
Females 13+ (preg/not nursing)              0.004046                 8.8%
Females 13+ (nursing)                       0.005640                12.3%

Males 13-19 yrs                             0.003256                 7.1%
Males 20+ yrs                               0.003690                 8.0%
Seniors 55+                                 0.003953                 8.6%

Children 1-2 yrs                            0.007290                15.8%
Children 3-5 yrs                            0.006535                14.2%
Children 6-12 yrs                           0.004383                 9.5%
Youth 13-19 yrs                             0.003164                 6.9%
Adults 20-49 yrs                            0.003821                 8.3%
Adults 50+ yrs                              0.003959                 8.6%
Females 13-49 yrs                           0.003802                 8.3%

-------------------------------------------------------------------------------
