UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C.  20460

 OFFICE OF CHEMICAL SAFETY AND

                                                                        
                            	POLLUTION PREVENTION

MEMORANDUM

DATE:  	07-June-2011

SUBJECT:	Tepraloxydim:  Acute and Chronic Dietary (Food and Drinking
Water) Exposure and Risk Assessment for Residues on Imported Crop
Subgroup 6C (Dried Shelled Pea and Bean) and Sunflower Subgroup 20B. 

PC Code:  121005	DP Num:  D384841

Decision No.:  440435	Registration No.:  EPA Reg. No. 8033-12

Petition No.:  0E7788	Regulatory Action:   Tolerance Assessment (no S3)

Risk Assessment Type:  Dietary Exposure 	Case No.:  NA

TXR No.:  NA	CAS No.:  149979-41-9

	40 CFR:  §180.573



REVIEWER:	Amelia M. Acierto

		Risk Assessment Branch III (RAB3)

Health Effects Division (7509P)

THROUGH:  Sheila Piper Chemist

		Meheret Negussie, Chemist

Dietary Exposure Science Advisory Council (DESAC)

Health Effects Division (7509P)

	

TO:		Barry O’Keefe, Risk Assessor

		Risk Assessment Branch III (RAB3)

Health Effects Division (7509P)

		

and

		Susan Stanton and James Tompkins, RM 25

Herbicide Branch 

Registration Division (7505P)

Executive Summary

™, Version 2.03), which uses food consumption data from the USDA’s
Continuing Surveys of Food Intakes by Individuals (CSFII) from 1994-1996
and 1998.  The analyses were performed to support a petition (PP#0E7788)
for the establishment of tolerances for the combined residues of
tepraloxydim and its metabolites convertible to GP
(3-(tetrahydropyran-4-yl)pentane-1,5-dioic acid) and OH-GP
(3-hydroxy-3-(tetrahydropyran-4-yl)pentane-1,5-dioic acid), calculated
as tepraloxydim in or on imported dry bean and sunflower subgroup 20B.

The latest acute and chronic dietary risk assessments was conducted on
dry pea, flax and lentil (DP# 338371, N. Dodd, 7/17/07).  The only
change made to the last assessment is the addition of dry bean and
sunflower subgroup 20B.  The conservative acute and chronic dietary
exposure assessments incorporated the same input parameters used in the
previous assessment including toxicological endpoints and estimated
drinking water concentrations.  As in the previous assessment, the
current assessment used residue values at the recommended and
established tolerance levels and assumed that 100 percent of the crops
were treated.  Residues of the proposed food commodities were based on
field trial data on dry bean and sunflower.  There are no processed
commodities for dry beans.  Processing factors for the sunflower
processed commodities (meal and refined oil) were set to 1 based on the
studies demonstrating that residues did not concentrate in the sunflower
processed fractions. 

Acute Dietary (Food and Drinking Water) Exposure Results and
Characterization 

The acute dietary exposure was estimated for females 13-49 years old
separately from the  general U.S. population since this population
subgroup has a different toxicological endpoint The acute surface water
Estimated Environmental Concentration (EEC) for tepraloxydim is 1.4 ppb.
 Based on the assumptions described above, the acute dietary exposure of
females 13-49 years old as well as the general U.S. population and
population subgroups are well below HED’s level of concern at the 95th
percentile of exposure.   Combined dietary exposure from food and
drinking water for female 13-49 years old at the 95th percentile of
exposure is estimated to be 0.001844 mg/kg/day, equivalent to <1%
(0.46%) of the acute Population Adjusted Dose (aPAD),  for the general
U.S. population, the exposure is estimated to be 0.003713 mg/kg/day,
equivalent to <1% (0.74%) of the aPAD, and children 1-2 years old the
exposure is estimated to be 0.010897 mg/kg/day, equivalent to 2.2% of
the aPAD, the most highly exposed subgroup.

 

Chronic Dietary (Food and Drinking Water) Exposure Results and
Characterization

The chronic dietary exposure and risk estimates are conservative since
they assume that 100% of crops are treated and that the residues are
present at tolerance level.  The chronic surface water EEC for
tepraloxydim is 0.7 ppb.   The water residues were incorporated directly
into the DEEM-FCID into the food categories “water, direct, all
sources” and “water, indirect, all sources.”  Combined chronic
dietary exposure estimates for food and drinking water are well 

below HED’s level of concern.  Using the DEEM-FCID software, dietary
exposure is estimated at 0.001213 mg/kg/day for the general U.S.
population equivalent to 2.4% of the chronic 

Population Adjusted Dose (cPAD) and 0.004825 mg/kg/day equivalent to
9.6% of the cPAD for children 1-2 years old, the population subgroup
with the highest estimated chronic dietary exposure to tepraloxydim.  

Cancer Exposure Results and Characterization

The cancer classification of tepraloxydim was summarized previously from
the CARC report dated 2/26/01, HED Doc. No. 014485, Ghazi Dannan,
2/26/01 (DP# 338371, N. Dodd, 7/17/07).  The HED’s Hazard
Identification Assessment Review Committee (HIARC) reevaluated the
original cancer classification of tepraloxydim as “not likely to be
carcinogenic to humans” and placed it into the category “Data are
inadequate for an assessment of human carcinogenic potential” because
although some evidence is suggestive of carcinogenic effects, other
equally pertinent evidence does not confirm a concern. 

I.	Introduction

Dietary risk assessment incorporates both exposure and toxicity of a
given pesticide.  For acute and chronic assessments, the risk is
expressed as a percentage of a maximum acceptable dose (i.e., the dose
which HED has concluded will result in no unreasonable adverse health
effects).  This dose is referred to as the population adjusted dose
(PAD).  The PAD is equivalent to point of departure (POD, NOAEL, LOAEL,
e.g.) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when
estimated dietary risk exceeds 100% of the PAD.  HED is generally
concerned when estimated cancer risk exceeds one in one million. 
References which discuss the acute and chronic risk assessments in more
detail are available on the EPA/pesticides web site:  “Available
Information on Assessing Exposure from Pesticides, A User’s Guide,”
6/21/2000, web link:      HYPERLINK
"http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf" 
http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf ; or see
SOP 99.6 (8/20/99).

The most recent dietary risk assessment for tepraloxydim was conducted
on 17-July-2007 (Memo, N. Dodd; DP# 338371).

			

II.	Residue Information

Residues of Concern:  The qualitative nature of the residues of
tepraloxydim in legume and oil seed is adequately understood based on
the available studies in soybean and canola.  HED’s Metabolism
Assessment Review Committee (MARC) concluded that tepraloxydim and the
metabolites containing the 2-cyclohexen-1-one moiety are the residues of
concern for canola and soybean.  HED has determined that the tolerance
expression includes the combined residues of tepraloxydim and its
metabolites convertible to GP (3-(tetrahydropyran-4-yl)pentane-1,5-dioic
acid) and OH-GP (3-hydroxy-3-(tetrahydropyran-4-yl)pentane-1,5-dioic
acid), calculated as tepraloxydim and concluded that no additional plant
metabolism data are required for new uses on legume and oil seed plants.


Established Tolerances: Tolerances have been established for plant
commodities under 40 CFR §180.573 (a)(1) for residues of tepraloxydim
and its metabolites convertible to GP
(3-(tetrahydropyran-4-yl)pentane-1,5-dioic acid) and OH-GP
(3-hydroxy-3-(tetrahydropyran-4-yl)pentane-1,5-dioic acid), calculated
as tepraloxydim, at 0.2 ppm for cotton, undelinted seed; 3.0 ppm for
cotton, gin byproducts; 0.10 ppm for flax, seed; lentil, seed; and pea,
dry, seed; 1200.0 ppm for aspirated grain fraction, 6.0 ppm for soybean,
seed and 8.0 ppm for soybean, hulls.   Tolerances have been established
for livestock commodities under §180.573(a)(2) for the combined
residues of tepraloxydim and its metabolites convertible to GP, OH-GP,
and GL (3-(2-oxotetrahydropyran-4-yl)-1,5-dioic acid), calculated as
tepraloxydim, at 0.15 – 0.50 ppm for fat, kidney, meat, and meat
by-products (except kidney) of cattle, goat, hog, horse, and sheep; 0.20
– 0.30 ppm for poultry fat, meat and meat products (except liver);
1.00 ppm for poultry liver; 0.20 ppm for eggs, and 0.10 ppm for milk.  
A tolerance with regional registration has been  established
under§180.573(c) for the combined residues of tepraloxydim and its
metabolites convertible to GP and OH-GP, calculated as tepraloxydim, for
canola, seed at 0.50 ppm. 

Recommended Tolerances:  BASF Corporation, on behalf of Nippon Soda
Company, submitted a petition (PP#0E7788) proposing the establishment of
tolerances for the combined residues of tepraloxydim
(2-[1-[[[(2E)-3-chloro-2-propenyl]oxy]imino]propyl]-3-hydroxy-5-(tetrahy
dro-2H-pyran-4-yl)-cyclohexene-1-one] and its metabolites convertible to
GP (3-(tetrahydropyran-4-yl)pentane-1,5-dioic acid) and OH-GP
(3-hydroxy-3-(tetrahydropyran-4-yl)pentane-1,5-dioic acid) in or on pea
and bean, dried, shelled, except soybean, subgroup 6C at 0.10 ppm and
sunflower subgroup 20B at 0.25 ppm.  HED has concluded that the new data
supplied for dry beans are sufficient to support the establishment of a
subgroup 6C tolerance and the proposed tolerance for sunflower subgroup
20B should be changed to 0.20 ppm to harmonize with the MRL for
sunflower in Canada.  The proposed tolerances and HED’s
recommendations based on review of field trial data are summarized in
Table 1.

 Table 1. Tolerance Summary for Tepraloxydim.



Commodity	Proposed Tolerance (ppm)	Recommended Tolerance (ppm)	Comments;
Correct Commodity Definition

Pea and bean dried shelled, except soybean, subgroup 6C	0.10	0.10	Bean,
dry, seed

Sunflower subgroup 20B	0.25	0.20	To harmonize with Canada.



Processed Commodities: There are no processed commodities associated
with dry bean (OPPTS 860.1000, Table 1).  Sunflower processed
commodities are sunflower meal and refined oil.  Seeds harvested from
crops treated at the exaggerated rate of >3x were harvested and
processed according to simulated commercial methods.  Combined residues
in duplicate treated seed samples were 0.11 and 0.22 ppm (tepraloxydim,
<0.05 ppm; 5-OH-DP, 0.06 and 0.17 ppm); in meal fractions, the combined
residues were <0.10 and 0.13 ppm (tepraloxydim, <0.05 ppm; 5-OH-DP, 0.05
and 0.08 ppm).  Residues were non-quantifiable in the refined oil.   The
data indicate that residues of tepraloxydim and its metabolites did not
concentrate in soybean meal or refined oil.  Therefore, all processing
factors in the residue file for the proposed sunflower commodities were
set to 1.  

III.	Drinking Water Data

There are no new drinking water data for tepraloxydim.   As in the last
dietary risk assessment, the drinking water residues and the estimated
surface water concentration are the values provided by the Environmental
Fate and Effects Division (EFED) in the following memorandum:  “Tier I
Drinking Water Assessment for Tepraloxydim” (J. Breithaupt, DP Number
338939, 5/1/07).   direct, all sources” and “water, indirect, all
sources.”   

The acute and chronic analyses were conducted using estimated surface
water concentrations  generated from the FIRST model.  The FIRST
modeling was performed with Index Reservoir (IR) scenarios and a percent
cropped area (PCA) adjustment factor of 0.87 as a default value,
according to the IR/PCA guidance from R.D. Jones et.al. (March 21,
2000).   The acute surface water Estimated Environmental Concentration
(EEC) for tepraloxydim is 1.4 ppb and the chronic surface water EEC is
0.7 ppb.   The PCA adjusted model results are presented in Table 2.  

 

Table 2. Drinking Water EECs for Tepraloxydim from Surface Water using
the FIRST Model.

Scenario and crop	Peak	Chronic Value

Soybean	1.4 ppb	0.7 ppb



The water values were incorporated directly into the DEEM-FCID into the
food categories “water, direct, all sources” and “water, indirest,
all sources”. 

The model and its description are available at the EPA internet site:  
HYPERLINK "http://www.epa.gov/oppefed1/models/water/" 
http://www.epa.gov/oppefed1/models/water/ .  

   

IV.	DEEM-FCID™ Program and Consumption Information

Tepraloxydim acute and chronic dietary exposure assessments were
conducted using DEEM-FCID™, Version 2.03, which incorporates
consumption data from USDA’s CSFII, 1994-1996 and 1998.  The 1994-96
and 1998 data are based on the reported consumption of more than 20,000
individuals over two non-consecutive survey days.  Foods “as
consumed” (e.g., apple pie) are linked to EPA-defined food commodities
(e.g. apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour
- cooked; fresh or N/S, baked) using publicly available recipe
translation files developed jointly by USDA/ARS and EPA.  For chronic
exposure assessment, consumption data are averaged for the entire U.S.
population and within population subgroups, but for acute exposure
assessment are retained as individual consumption events.  Based on
analysis of the 1994-96 and 1998 CSFII consumption data, which took into
account dietary patterns and survey respondents, HED concluded that it
is most appropriate to report risk for the following population
subgroups: the general U.S. population, all infants (<1 year old),
children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49,
females 13-49, and adults 50+ years old.

For chronic dietary exposure assessments, an estimate of the residue
level in each food or food-form (e.g., orange or orange juice) on the
food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form to produce a
residue intake estimate.  The resulting residue intake estimate for each
food/food form is summed with the residue intake estimates for all other
food/food forms on the commodity residue list to arrive at the total
average estimated exposure.  Exposure is expressed in mg/kg body
weight/day and as a percent of the cPAD.  This procedure is performed
for each population subgroup.

For acute exposure assessments, individual one-day food consumption data
are used on an individual-by-individual basis.  The reported consumption
amounts of each food item can be multiplied by a residue point estimate
and summed to obtain a total daily pesticide exposure for a
deterministic exposure assessment, or “matched” in multiple random
pairings with residue values and then summed in a probabilistic
assessment.  The resulting distribution of exposures is expressed as a
percentage of the aPAD on both a user (i.e., only those who reported
eating relevant commodities/food forms) and a per-capita (i.e., those
who reported eating the relevant commodities as well as those who did
not) basis.  In accordance with HED policy, per capita exposure and risk
are reported for all tiers of analysis.  However, for Tiers 1 and 2, any
significant differences in user vs. per capita exposure and risk are
specifically identified and noted in the risk assessment.

V.	Toxicological Information

Historical background surrounding the toxicological endpoint selection,
decisions on the FQPA safety factors, and reevaluation of the cancer
classification were described in detail in the latest dietary exposure
assessment memo (DP# 338371, N. Dodd, 7/17/2007).  No new information
has been received since the previous dietary risk assessment.  The
available toxicity database for tepraloxydim, including developmental
toxicity studies in rats and rabbits and a two-generation reproduction
study in rats was reviewed for the purpose of the current risk
assessment and HED has concluded that the database is adequate for
evaluating the FQPA safety factor.  

The doses and toxicological endpoints selected for dietary risk
assessment are summarized in Table 3.  

Table 3.  Summary of Toxicological Doses and Endpoints for Tepraloxydim
for Use in Dietary Exposure Risk                                        
            Assessments

Exposure/

Scenario	Point of Departure	Uncertainty/FQPA Safety Factors	RfD, PAD,
Level of Concern for Risk Assessment	Study and Toxicological Effects

Acute Dietary (General Population, including Infants and Children)	LOAEL
= 500 mg/kg/day	UFA= 10x

UFH= 10x

FQPA SF retained as UFL= 10x

	Acute RfD = 0.5 mg/kg/day

aPAD = 0.5 mg/kg/day	Acute neurotoxicity screening battery (MRID
44467136)

LOAEL = 500 mg/kg/day based on decreased motor activity in females. 
(The NOAEL is not identified.)

Acute Dietary

(Females 13-49 years of age)	NOAEL = 40 mg/kg/day	UFA= 10x

UFH= 10x

FQPA SF= 1x

	Acute RfD = 0.4 mg/kg/day

aPAD = 0.4 mg/kg/day	Rat developmental toxicity  (MRID 44467203)

LOAEL = 120 mg/kg/day based on findings of reduced ossification
indicative of delayed maturation, and the occurrence of hydroureter.

Chronic Dietary (All Populations)	NOAEL= 5 mg/kg/day	UFA= 10x

UFH= 10x

FQPA SF= 1x

	Chronic RfD = 0.05mg/kg/day

cPAD = 0.05 mg/kg/day	Rat carcinogenicity study (MRID 44467201)

LOAEL = 30 mg/kg/day based on male liver microscopic lesions
(eosinophilic foci).

Cancer (oral, dermal, inhalation)   	The CARC placed tepraloxydim into
the category “Data are inadequate for an assessment of human
carcinogenic potential” because some evidence is suggestive of
carcinogenic effects, but other equally pertinent evidence does not
confirm a concern” and determined that the quantification of human
cancer risk is not required (CARC report dated 2/26/01, HED Doc. No.
014487). 

Point of Departure (POD) = A data point or an estimated point that is
derived from observed dose-response data and used to mark the beginning
of extrapolation to determine risk associated with lower environmentally
relevant human exposures.  NOAEL = no observed adverse effect level. 
LOAEL = lowest observed adverse effect level.  UF = uncertainty factor. 
UFA = extrapolation from animal to human (interspecies).  UFH =
potential variation in sensitivity among members of the human population
(intraspecies).  UFL = use of a LOAEL to extrapolate to a NOAEL.  UFDB =
to account for the absence of key data (i.e., lack of a critical study).
 FQPA SF = FQPA Safety Factor.  DNT = Developmental Neurotoxicity.  PAD
= population adjusted dose (a = acute, c = chronic).  RfD = reference
dose.  

VI.	Results/Discussion 

 is concerned when dietary risk exceeds 100% of the PAD.  The
DEEM-FCID™ analyses estimate the dietary exposure of the U.S.
population and various population subgroups.  The acute and chronic
dietary exposure estimate for the general U.S. population, all infants
(<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19,
females 13-49, adults 20-49, and adults 50+ years are summarized in
Table 4.   

Results of Acute and Chronic Dietary (Food and Drinking Water) Exposure
Analysis for the general U.S. population and population subgroups

The results of the acute and chronic dietary exposure of the general
U.S. population and population subgroups to tepraloxydim from food and
drinking water are below the Agency’s level of concern [i.e., <100%
acute and chronic population-adjusted dose (aPAD and cPAD)].  The acute
dietary exposure was estimated at 0.003713 mg/kg/day (equivalent to <1 %
of the aPAD) for the general U.S. population and 0.010897 mg/kg/day
(equivalent to 2.2% of the aPAD) for children 1-2 years old, the most
highly exposed population subgroup.  The acute dietary exposure of
females 13-49 years old at the 95th percentile of exposure is estimated
to be 0.001844 mg/kg/day, equivalent to <1% (0.46%) of the aPAD;
therefore, is not of concern to HED (i.e., <100% aPAD).  

The chronic dietary exposure was estimated at 0.001213 mg/kg/day
(equivalent to 2.4% of the cPAD) for the general U.S. population and
0.004825 mg/kg/day (equivalent to 9.6% of the cPAD) for children 1-2
years old, the most highly exposed population subgroup.   The estimated
acute and chronic exposure risk from food and drinking water for the
general U.S. population, all infants (<1 year old), children 1-2,
children 3-5, children 6-12, youth 13-19, females 13-49,  adults 20-49,
and adults 50+ years are summarized in Table 4.  

Table 4.  Summary of Dietary (Food and Drinking Water) Exposure and Risk
for Tepraloxydim

Population Subgroup	Acute Dietary

(95th Percentile)	Chronic Dietary	Cancer

	aPAD	Dietary Exposure (mg/kg/day)1	% aPAD	Dietary Exposure

(mg/kg/day)1	% cPAD	Dietary Exposure

(mg/kg/day)	Risk                                                        

General U.S. Population	0.5	0.003713	<1	0.001213	2.4	N/A2	N/A2

All Infants (< 1 year old)	0.5	0.005947	 1	0.001761	4	N/A	N/A

Children 1-2 years old	0.5	0.010897	 2.2	0.004825	9.6



Children 3-5 years old	0.5	0.006858	 1	0.003404	7



Children 6-12 years old	0.5	0.004459	 <1	0.002092	4



Youth 13-19 years old	0.5	0.002612	<1	0.001089	2



Adults 20-49 years old	0.5	0.001902	<1	0.000817	2



Adults 50+ years old	0.5	0.001560	<1	0.000721	1



Females 13-49 years old	0.4	0.001844	 <1	0.000774	2



1The values for the highest exposed population are bolded.

2Data are inadequate for an assessment of human carcinogenic potential 

VII.	Characterization of Inputs/Outputs

The acute and chronic dietary exposure and risk estimates are
conservative since they assume that 100% of crops are treated with
tepraloxydim and that the residues are present at tolerance levels.  The
drinking water exposure estimates were based on screening level
estimates generated by the FIRST model.  Although not needed at this
time, HED could refine the exposure and risk estimates through the use
of anticipated residues and percent crop treated data as well as refined
estimated drinking water concentrations.  However, since estimated
exposures and risks using conservative assumptions are well below
HED’s level of concern, such refinement is not warranted.

VIII.		Conclusions

These unrefined dietary exposure analyses using DEEM-FCIDTM indicate
that acute and chronic dietary exposure to tepraloxydim from food and
drinking water are well below HED’s level of concern (i.e., <100%
aPAD).  Combined acute dietary exposure of the general U.S. population
from food and drinking water at the 95th percentile of exposure is
estimated to be 0.003713 mg/kg/day, equivalent to <1%  of the aPAD and
0.010897 mg/kg/day equivalent to 2.2% of the 

aPAD for children 1-2 years old, the most highly exposed subgroup.  The
estimated acute exposure of females 13-49 years old represents <1% of
the aPAD at the 95th percentile of 

exposure.   The chronic dietary exposure to tepraloxydim from food +
drinking water is 2.4% of the cPAD for the general U.S. population and
9.6% of the cPAD for children 1-2 years old, the most highly exposed
population subgroup. 

IX.		List of Attachments

Attachment 1:  Acute Food plus Water Residue Input File (Female 13-49)

Attachment 2:  Acute Food plus Water Results File (Female 13-49)

Attachment 3:  Acute Food plus Water Residue Input File (General
Population)

Attachment 4:  Acute Food plus Water Results File (General Population)

Attachment 5:  Chronic Food plus Water Residue Input File

Attachment 6:  Chronic Food plus Water Results File

Attachment 1:  Acute Food plus Water Residue Input File (Female 13-49)

U.S. Environmental Protection Agency                                
Ver. 2.02

DEEM-FCID Acute analysis for TEPRALOXYDIM

Residue file name: C:\Documents and Settings\aacierto\Desktop\DEEM-FCID
Files\2011\tepraloxydimAcuteFemale 13+.R98

Analysis Date 06-16-2011             Residue file dated:
06-16-2011/17:15:16/8

Reference dose: aRfD = 0.4 mg/kg bw/day  NOEL = 40 mg/kg bw/day

------------------------------------------------------------------------
--------

  EPA    Crop                                   Def Res     Adj.Factors 
 Comment

  Code    Grp  Food Name                         (ppm)       #1    #2   

-------- ---- -------------------------------  ----------  ------ ------
 -------

06030300 6C   Bean, black, seed                  0.100000   1.000  1.000

06030320 6C   Bean, broad, seed                  0.100000   1.000  1.000

06030340 6C   Bean, cowpea, seed                 0.100000   1.000  1.000

06030350 6C   Bean,  great northern, seed        0.100000   1.000  1.000

06030360 6C   Bean, kidney, seed                 0.100000   1.000  1.000

06030380 6C   Bean, lima, seed                   0.100000   1.000  1.000

06030390 6C   Bean, mung, seed                   0.100000   1.000  1.000

06030400 6C   Bean, navy, seed                   0.100000   1.000  1.000

06030410 6C   Bean, pink, seed                   0.100000   1.000  1.000

06030420 6C   Bean, pinto, seed                  0.100000   1.000  1.000

21000440 M    Beef, meat                         0.200000   1.000  1.000

21000441 M    Beef, meat-babyfood                0.200000   1.000  1.000

21000450 M    Beef, meat, dried                  0.200000   1.920  1.000

21000460 M    Beef, meat byproducts              0.200000   1.000  1.000

21000461 M    Beef, meat byproducts-babyfood     0.200000   1.000  1.000

21000470 M    Beef, fat                          0.150000   1.000  1.000

21000471 M    Beef,fat-babyfood                  0.150000   1.000  1.000

21000480 M    Beef, kidney                       0.500000   1.000  1.000

40000930 P    Chicken, meat                      0.200000   1.000  1.000

40000931 P    Chicken, meat-babyfood             0.200000   1.000  1.000

40000940 P    Chicken, liver                     1.000000   1.000  1.000

40000950 P    Chicken, meat byproducts           0.200000   1.000  1.000

40000951 P    Chicken, meat byproducts-babyfoo   0.200000   1.000  1.000

40000960 P    Chicken, fat                       0.300000   1.000  1.000

40000961 P    Chicken, fat-babyfood              0.300000   1.000  1.000

40000970 P    Chicken, skin                      0.200000   1.000  1.000

40000971 P    Chicken, skin-babyfood             0.200000   1.000  1.000

06030980 6C   Chickpea, seed                     0.100000   1.000  1.000

06030981 6C   Chickpea, seed-babyfood            0.100000   1.000  1.000

06030990 6C   Chickpea, flour                    0.100000   1.000  1.000

95001280 O    Cottonseed, oil                    0.200000   1.000  1.000

95001281 O    Cottonseed, oil-babyfood           0.200000   1.000  1.000

70001450 P    Egg, whole                         0.200000   1.000  1.000

70001451 P    Egg, whole-babyfood                0.200000   1.000  1.000

70001460 P    Egg, white                         0.200000   1.000  1.000

70001461 P    Egg, white (solids)-babyfood       0.200000   1.000  1.000

70001470 P    Egg, yolk                          0.200000   1.000  1.000

70001471 P    Egg, yolk-babyfood                 0.200000   1.000  1.000

20001630 20   Flaxseed, oil                      0.200000   1.000  1.000

23001690 M    Goat, meat                         0.200000   1.000  1.000

23001700 M    Goat, meat byproducts              0.200000   1.000  1.000

23001710 M    Goat, fat                          0.150000   1.000  1.000

23001720 M    Goat, kidney                       0.500000   1.000  1.000

06031820 6C   Guar, seed                         0.100000   1.000  1.000

06031821 6C   Guar, seed-babyfood                0.100000   1.000  1.000

24001890 M    Horse, meat                        0.200000   1.000  1.000

06032030 6C   Lentil, seed                       0.100000   1.000  1.000

27002220 D    Milk, fat                          0.100000   1.000  1.000

27002221 D    Milk, fat - baby food/infant for   0.100000   1.000  1.000

27012230 D    Milk, nonfat solids                0.100000   1.000  1.000

27012231 D    Milk, nonfat solids-baby food/in   0.100000   1.000  1.000

27022240 D    Milk, water                        0.100000   1.000  1.000

27022241 D    Milk, water-babyfood/infant form   0.100000   1.000  1.000

27032251 D    Milk, sugar (lactose)-baby food/   0.100000   1.000  1.000

06032560 6C   Pea, dry                           0.100000   1.000  1.000

06032561 6C   Pea, dry-babyfood                  0.100000   1.000  1.000

06032580 6C   Pea, pigeon, seed                  0.100000   1.000  1.000

25002900 M    Pork, meat                         0.200000   1.000  1.000

25002901 M    Pork, meat-babyfood                0.200000   1.000  1.000

25002910 M    Pork, skin                         0.200000   1.000  1.000

25002920 M    Pork, meat byproducts              0.200000   1.000  1.000

25002921 M    Pork, meat byproducts-babyfood     0.200000   1.000  1.000

25002930 M    Pork, fat                          0.150000   1.000  1.000

25002931 M    Pork, fat-babyfood                 0.150000   1.000  1.000

25002940 M    Pork, kidney                       0.500000   1.000  1.000

60003010 P    Poultry, other, meat               0.200000   1.000  1.000

60003020 P    Poultry, other, liver              1.000000   1.000  1.000

60003030 P    Poultry, other, meat byproducts    0.200000   1.000  1.000

60003040 P    Poultry, other, fat                0.300000   1.000  1.000

60003050 P    Poultry, other, skin               0.200000   1.000  1.000

20003190 20   Rapeseed, oil                      0.200000   1.000  1.000

20003191 20   Rapeseed, oil-babyfood             0.200000   1.000  1.000

20003300 20   Safflower, oil                     0.200000   1.000  1.000

20003301 20   Safflower, oil-babyfood            0.200000   1.000  1.000

26003390 M    Sheep, meat                        0.200000   1.000  1.000

26003391 M    Sheep, meat-babyfood               0.200000   1.000  1.000

26003400 M    Sheep, meat byproducts             0.200000   1.000  1.000

26003410 M    Sheep, fat                         0.150000   1.000  1.000

26003411 M    Sheep, fat-babyfood                0.150000   1.000  1.000

26003420 M    Sheep, kidney                      0.500000   1.000  1.000

06003470 6    Soybean, seed                      6.000000   1.000  1.000

20003640 20   Sunflower, seed                    0.200000   1.000  1.000

20003650 20   Sunflower, oil                     0.200000   1.000  1.000

20003651 20   Sunflower, oil-babyfood            0.200000   1.000  1.000

50003820 P    Turkey, meat                       0.200000   1.000  1.000

50003821 P    Turkey, meat-babyfood              0.200000   1.000  1.000

50003830 P    Turkey, liver                      1.000000   1.000  1.000

50003831 P    Turkey, liver-babyfood             1.000000   1.000  1.000

50003840 P    Turkey, meat byproducts            0.200000   1.000  1.000

50003841 P    Turkey, meat byproducts-babyfood   0.200000   1.000  1.000

50003850 P    Turkey, fat                        0.300000   1.000  1.000

50003851 P    Turkey, fat-babyfood               0.300000   1.000  1.000

50003860 P    Turkey, skin                       0.200000   1.000  1.000

50003861 P    Turkey, skin-babyfood              0.200000   1.000  1.000

86010000 O    Water, direct, all sources         0.001400   1.000  1.000

86020000 O    Water, indirect, all sources       0.001400   1.000  1.000

Attachment 2:  Acute Food plus Water Results File (Female 13-49)

U.S. Environmental Protection Agency                                 
Ver. 2.02

DEEM-FCID ACUTE Analysis for TEPRALOXYDIM                       
(1994-98 data)

Residue file: tepraloxydimAcuteFemale 13+.R98     Adjustment factor #2
NOT used.

Analysis Date: 06-16-2011/17:17:11    Residue file dated:
06-16-2011/17:15:16/8

NOEL (Acute) =  40.000000 mg/kg body-wt/day

Daily totals for food and foodform consumption used.

Run Comment: ""

========================================================================
=======

Summary calculations (per capita):

      95th Percentile             99th Percentile             99.9th
Percentile

 Exposure  % aRfD     MOE    Exposure  % aRfD     MOE    Exposure  %
aRfD     MOE  

---------- ------- -------- ---------- ------- -------- ----------
------- --------

Females 13-49 yrs:

  0.001844    0.46   21686    0.002755    0.69   14521    0.004769   
1.19    8387  



Attachment 3:  Acute Food plus Water Input File (General Population)

U.S. Environmental Protection Agency                                
Ver. 2.02

DEEM-FCID Acute analysis for TEPRALOXYDIM

Residue file name: C:\Documents and Settings\aacierto\Desktop\DEEM-FCID
Files\2011\tepraloxydimAcuteGenPop.R98

Analysis Date 06-16-2011             Residue file dated:
06-16-2011/17:06:36/8

Reference dose (aRfD) = 0.5 mg/kg bw/day

Comment: Dry beans and sunflower

------------------------------------------------------------------------
--------

  EPA    Crop                                   Def Res     Adj.Factors 
 Comment

  Code    Grp  Food Name                         (ppm)       #1    #2   

-------- ---- -------------------------------  ----------  ------ ------
 -------

06030300 6C   Bean, black, seed                  0.100000   1.000  1.000

06030320 6C   Bean, broad, seed                  0.100000   1.000  1.000

06030340 6C   Bean, cowpea, seed                 0.100000   1.000  1.000

06030350 6C   Bean,  great northern, seed        0.100000   1.000  1.000

06030360 6C   Bean, kidney, seed                 0.100000   1.000  1.000

06030380 6C   Bean, lima, seed                   0.100000   1.000  1.000

06030390 6C   Bean, mung, seed                   0.100000   1.000  1.000

06030400 6C   Bean, navy, seed                   0.100000   1.000  1.000

06030410 6C   Bean, pink, seed                   0.100000   1.000  1.000

06030420 6C   Bean, pinto, seed                  0.100000   1.000  1.000

21000440 M    Beef, meat                         0.200000   1.000  1.000

21000441 M    Beef, meat-babyfood                0.200000   1.000  1.000

21000450 M    Beef, meat, dried                  0.200000   1.920  1.000

21000460 M    Beef, meat byproducts              0.200000   1.000  1.000

21000461 M    Beef, meat byproducts-babyfood     0.200000   1.000  1.000

21000470 M    Beef, fat                          0.150000   1.000  1.000

21000471 M    Beef,fat-babyfood                  0.150000   1.000  1.000

21000480 M    Beef, kidney                       0.500000   1.000  1.000

40000930 P    Chicken, meat                      0.200000   1.000  1.000

40000931 P    Chicken, meat-babyfood             0.200000   1.000  1.000

40000940 P    Chicken, liver                     1.000000   1.000  1.000

40000950 P    Chicken, meat byproducts           0.200000   1.000  1.000

40000951 P    Chicken, meat byproducts-babyfoo   0.200000   1.000  1.000

40000960 P    Chicken, fat                       0.300000   1.000  1.000

40000961 P    Chicken, fat-babyfood              0.300000   1.000  1.000

40000970 P    Chicken, skin                      0.200000   1.000  1.000

40000971 P    Chicken, skin-babyfood             0.200000   1.000  1.000

06030980 6C   Chickpea, seed                     0.100000   1.000  1.000

06030981 6C   Chickpea, seed-babyfood            0.100000   1.000  1.000

06030990 6C   Chickpea, flour                    0.100000   1.000  1.000

95001280 O    Cottonseed, oil                    0.200000   1.000  1.000

95001281 O    Cottonseed, oil-babyfood           0.200000   1.000  1.000

70001450 P    Egg, whole                         0.200000   1.000  1.000

70001451 P    Egg, whole-babyfood                0.200000   1.000  1.000

70001460 P    Egg, white                         0.200000   1.000  1.000

70001461 P    Egg, white (solids)-babyfood       0.200000   1.000  1.000

70001470 P    Egg, yolk                          0.200000   1.000  1.000

70001471 P    Egg, yolk-babyfood                 0.200000   1.000  1.000

20001630 20   Flaxseed, oil                      0.250000   1.000  1.000

23001690 M    Goat, meat                         0.200000   1.000  1.000

23001700 M    Goat, meat byproducts              0.200000   1.000  1.000

23001710 M    Goat, fat                          0.150000   1.000  1.000

23001720 M    Goat, kidney                       0.500000   1.000  1.000

06031820 6C   Guar, seed                         0.100000   1.000  1.000

06031821 6C   Guar, seed-babyfood                0.100000   1.000  1.000

24001890 M    Horse, meat                        0.200000   1.000  1.000

06032030 6C   Lentil, seed                       0.100000   1.000  1.000

27002220 D    Milk, fat                          0.100000   1.000  1.000

27002221 D    Milk, fat - baby food/infant for   0.100000   1.000  1.000

27012230 D    Milk, nonfat solids                0.100000   1.000  1.000

27012231 D    Milk, nonfat solids-baby food/in   0.100000   1.000  1.000

27022240 D    Milk, water                        0.100000   1.000  1.000

27022241 D    Milk, water-babyfood/infant form   0.100000   1.000  1.000

27032251 D    Milk, sugar (lactose)-baby food/   0.100000   1.000  1.000

06032560 6C   Pea, dry                           0.100000   1.000  1.000

06032561 6C   Pea, dry-babyfood                  0.100000   1.000  1.000

06032580 6C   Pea, pigeon, seed                  0.100000   1.000  1.000

25002900 M    Pork, meat                         0.200000   1.000  1.000

25002901 M    Pork, meat-babyfood                0.200000   1.000  1.000

25002910 M    Pork, skin                         0.200000   1.000  1.000

25002920 M    Pork, meat byproducts              0.200000   1.000  1.000

25002921 M    Pork, meat byproducts-babyfood     0.200000   1.000  1.000

25002930 M    Pork, fat                          0.150000   1.000  1.000

25002931 M    Pork, fat-babyfood                 0.150000   1.000  1.000

25002940 M    Pork, kidney                       0.500000   1.000  1.000

60003010 P    Poultry, other, meat               0.200000   1.000  1.000

60003020 P    Poultry, other, liver              1.000000   1.000  1.000

60003030 P    Poultry, other, meat byproducts    0.200000   1.000  1.000

60003040 P    Poultry, other, fat                0.300000   1.000  1.000

60003050 P    Poultry, other, skin               0.200000   1.000  1.000

20003190 20   Rapeseed, oil                      0.250000   1.000  1.000

20003191 20   Rapeseed, oil-babyfood             0.250000   1.000  1.000

20003300 20   Safflower, oil                     0.250000   1.000  1.000

20003301 20   Safflower, oil-babyfood            0.250000   1.000  1.000

26003390 M    Sheep, meat                        0.200000   1.000  1.000

26003391 M    Sheep, meat-babyfood               0.200000   1.000  1.000

26003400 M    Sheep, meat byproducts             0.200000   1.000  1.000

26003410 M    Sheep, fat                         0.150000   1.000  1.000

26003411 M    Sheep, fat-babyfood                0.150000   1.000  1.000

26003420 M    Sheep, kidney                      0.500000   1.000  1.000

06003470 6    Soybean, seed                      6.000000   1.000  1.000

20003640 20   Sunflower, seed                    0.250000   1.000  1.000

20003650 20   Sunflower, oil                     0.250000   1.000  1.000

20003651 20   Sunflower, oil-babyfood            0.250000   1.000  1.000

50003820 P    Turkey, meat                       0.200000   1.000  1.000

50003821 P    Turkey, meat-babyfood              0.200000   1.000  1.000

50003830 P    Turkey, liver                      1.000000   1.000  1.000

50003831 P    Turkey, liver-babyfood             1.000000   1.000  1.000

50003840 P    Turkey, meat byproducts            0.200000   1.000  1.000

50003841 P    Turkey, meat byproducts-babyfood   0.200000   1.000  1.000

50003850 P    Turkey, fat                        0.300000   1.000  1.000

50003851 P    Turkey, fat-babyfood               0.300000   1.000  1.000

50003860 P    Turkey, skin                       0.200000   1.000  1.000

50003861 P    Turkey, skin-babyfood              0.200000   1.000  1.000

86010000 O    Water, direct, all sources         0.001400   1.000  1.000

86020000 O    Water, indirect, all sources       0.001400   1.000  1.000

Attachment 4:  Acute Food plus Water Results File (General Population)

U.S. Environmental Protection Agency                                 
Ver. 2.02

DEEM-FCID ACUTE Analysis for TEPRALOXYDIM                       
(1994-98 data)

Residue file: tepraloxydimAcuteGenPop.R98         Adjustment factor #2
NOT used.

Analysis Date: 06-16-2011/17:08:11    Residue file dated:
06-16-2011/17:06:36/8

Daily totals for food and foodform consumption used.

Run Comment: "Dry beans and sunflower"

========================================================================
=======

Summary calculations (per capita):

                    95th Percentile      99th Percentile      99.9th
Percentile

                   Exposure   % aRfD    Exposure   % aRfD    Exposure  
% aRfD 

                  ---------- --------  ---------- --------  ----------
--------

U.S. Population:

                    0.003713     0.74    0.006988     1.40    0.013129  
  2.63 

All infants:

                    0.005947     1.19    0.014895     2.98    0.019549  
  3.91 

Children 1-2 yrs:

                    0.010897     2.18    0.014923     2.98    0.021078  
  4.22 

Children 3-5 yrs:

                    0.006858     1.37    0.009443     1.89    0.016522  
  3.30 

Children 6-12 yrs:

                    0.004459     0.89    0.005921     1.18    0.009827  
  1.97 

Youth 13-19 yrs:

                    0.002612     0.52    0.003888     0.78    0.008805  
  1.76 

Adults 20-49 yrs:

                    0.001902     0.38    0.002848     0.57    0.005310  
  1.06 

Adults 50+ yrs:

                    0.001560     0.31    0.002194     0.44    0.003047  
  0.61 



Attachment 5:  Chronic Food plus Water Residue Input File

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for TEPRALOXYDIM                      
1994-98 data

Residue file: C:\Documents and Settings\aacierto\Desktop\DEEM-FCID
Files\2011\TepraloxydimChronic(food+water).R98

                                                           Adjust. #2
NOT used

Analysis Date 06-16-2011             Residue file dated:
06-16-2011/17:32:23/8

Reference dose (RfD) = 0.05  (NOEL) = 5 mg/kg bw/day

Comment:Dry bean and sunflower subgroup 20B

------------------------------------------------------------------------
--------

Food Crop                                       Residue      
Adj.Factors      Comment

EPA Code  Grp  Food Name                          (ppm)       

                                                             #1        
#2 

-------- ---- -------------------------------   ---------- ------    
------   -------

06030300 6C   Bean, black, seed                  0.100000   1.000     
1.000   

06030320 6C   Bean, broad, seed                  0.100000   1.000     
1.000   

06030340 6C   Bean, cowpea, seed                 0.100000   1.000     
1.000   

06030350 6C   Bean,  great northern, seed        0.100000   1.000     
1.000   

06030360 6C   Bean, kidney, seed                 0.100000   1.000     
1.000   

06030380 6C   Bean, lima, seed                   0.100000   1.000     
1.000   

06030390 6C   Bean, mung, seed                   0.100000   1.000     
1.000   

06030400 6C   Bean, navy, seed                   0.100000   1.000     
1.000   

06030410 6C   Bean, pink, seed                   0.100000   1.000     
1.000   

06030420 6C   Bean, pinto, seed                  0.100000   1.000     
1.000   

21000440 M    Beef, meat                         0.200000   1.000     
1.000   

21000441 M    Beef, meat-babyfood                0.200000   1.000     
1.000   

21000450 M    Beef, meat, dried                  0.200000   1.920     
1.000   

21000460 M    Beef, meat byproducts              0.200000   1.000     
1.000   

21000461 M    Beef, meat byproducts-babyfood     0.200000   1.000     
1.000   

21000470 M    Beef, fat                          0.150000   1.000     
1.000   

21000471 M    Beef,fat-babyfood                  0.150000   1.000     
1.000   

21000480 M    Beef, kidney                       0.500000   1.000     
1.000   

40000930 P    Chicken, meat                      0.200000   1.000     
1.000   

40000931 P    Chicken, meat-babyfood             0.200000   1.000     
1.000   

40000940 P    Chicken, liver                     1.000000   1.000     
1.000   

40000950 P    Chicken, meat byproducts           0.200000   1.000     
1.000   

40000951 P    Chicken, meat byproducts-babyfoo   0.200000   1.000     
1.000   

40000960 P    Chicken, fat                       0.300000   1.000     
1.000   

40000961 P    Chicken, fat-babyfood              0.300000   1.000     
1.000   

40000970 P    Chicken, skin                      0.200000   1.000     
1.000   

40000971 P    Chicken, skin-babyfood             0.200000   1.000     
1.000   

06030980 6C   Chickpea, seed                     0.100000   1.000     
1.000   

06030981 6C   Chickpea, seed-babyfood            0.100000   1.000     
1.000   

06030990 6C   Chickpea, flour                    0.100000   1.000     
1.000   

95001280 O    Cottonseed, oil                    0.200000   1.000     
1.000   

95001281 O    Cottonseed, oil-babyfood           0.200000   1.000     
1.000   

70001450 P    Egg, whole                         0.200000   1.000     
1.000   

70001451 P    Egg, whole-babyfood                0.200000   1.000     
1.000   

70001460 P    Egg, white                         0.200000   1.000     
1.000   

70001461 P    Egg, white (solids)-babyfood       0.200000   1.000     
1.000   

70001470 P    Egg, yolk                          0.200000   1.000     
1.000   

70001471 P    Egg, yolk-babyfood                 0.200000   1.000     
1.000   

20001630 20   Flaxseed, oil                      0.200000   1.000     
1.000   

23001690 M    Goat, meat                         0.200000   1.000     
1.000   

23001700 M    Goat, meat byproducts              0.200000   1.000     
1.000   

23001710 M    Goat, fat                          0.150000   1.000     
1.000   

23001720 M    Goat, kidney                       0.500000   1.000     
1.000   

06031820 6C   Guar, seed                         0.100000   1.000     
1.000   

06031821 6C   Guar, seed-babyfood                0.100000   1.000     
1.000   

24001890 M    Horse, meat                        0.200000   1.000     
1.000   

06032030 6C   Lentil, seed                       0.100000   1.000     
1.000   

27002220 D    Milk, fat                          0.100000   1.000     
1.000   

27002221 D    Milk, fat - baby food/infant for   0.100000   1.000     
1.000   

27012230 D    Milk, nonfat solids                0.100000   1.000     
1.000   

27012231 D    Milk, nonfat solids-baby food/in   0.100000   1.000     
1.000   

27022240 D    Milk, water                        0.100000   1.000     
1.000   

27022241 D    Milk, water-babyfood/infant form   0.100000   1.000     
1.000   

27032251 D    Milk, sugar (lactose)-baby food/   0.100000   1.000     
1.000   

06032560 6C   Pea, dry                           0.100000   1.000     
1.000   

06032561 6C   Pea, dry-babyfood                  0.100000   1.000     
1.000   

06032580 6C   Pea, pigeon, seed                  0.100000   1.000     
1.000   

25002900 M    Pork, meat                         0.200000   1.000     
1.000   

25002901 M    Pork, meat-babyfood                0.200000   1.000     
1.000   

25002910 M    Pork, skin                         0.200000   1.000     
1.000   

25002920 M    Pork, meat byproducts              0.200000   1.000     
1.000   

25002921 M    Pork, meat byproducts-babyfood     0.200000   1.000     
1.000   

25002930 M    Pork, fat                          0.150000   1.000     
1.000   

25002931 M    Pork, fat-babyfood                 0.150000   1.000     
1.000   

25002940 M    Pork, kidney                       0.500000   1.000     
1.000   

60003010 P    Poultry, other, meat               0.200000   1.000     
1.000   

60003020 P    Poultry, other, liver              1.000000   1.000     
1.000   

60003030 P    Poultry, other, meat byproducts    0.200000   1.000     
1.000   

60003040 P    Poultry, other, fat                0.300000   1.000     
1.000   

60003050 P    Poultry, other, skin               0.200000   1.000     
1.000   

20003190 20   Rapeseed, oil                      0.200000   1.000     
1.000   

20003191 20   Rapeseed, oil-babyfood             0.200000   1.000     
1.000   

20003300 20   Safflower, oil                     0.200000   1.000     
1.000   

20003301 20   Safflower, oil-babyfood            0.200000   1.000     
1.000   

26003390 M    Sheep, meat                        0.200000   1.000     
1.000   

26003391 M    Sheep, meat-babyfood               0.200000   1.000     
1.000   

26003400 M    Sheep, meat byproducts             0.200000   1.000     
1.000   

26003410 M    Sheep, fat                         0.150000   1.000     
1.000   

26003411 M    Sheep, fat-babyfood                0.150000   1.000     
1.000   

26003420 M    Sheep, kidney                      0.500000   1.000     
1.000   

06003470 6    Soybean, seed                      6.000000   1.000     
1.000   

20003640 20   Sunflower, seed                    0.200000   1.000     
1.000   

20003650 20   Sunflower, oil                     0.200000   1.000     
1.000   

20003651 20   Sunflower, oil-babyfood            0.200000   1.000     
1.000   

50003820 P    Turkey, meat                       0.200000   1.000     
1.000   

50003821 P    Turkey, meat-babyfood              0.200000   1.000     
1.000   

50003830 P    Turkey, liver                      1.000000   1.000     
1.000   

50003831 P    Turkey, liver-babyfood             1.000000   1.000     
1.000   

50003840 P    Turkey, meat byproducts            0.200000   1.000     
1.000   

50003841 P    Turkey, meat byproducts-babyfood   0.200000   1.000     
1.000   

50003850 P    Turkey, fat                        0.300000   1.000     
1.000   

50003851 P    Turkey, fat-babyfood               0.300000   1.000     
1.000   

50003860 P    Turkey, skin                       0.200000   1.000     
1.000   

50003861 P    Turkey, skin-babyfood              0.200000   1.000     
1.000   

86010000 O    Water, direct, all sources         0.000700   1.000     
1.000   

86020000 O    Water, indirect, all sources       0.000700   1.000     
1.000   

Attachment 6:  Chronic Food plus Water Results File

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for TEPRALOXYDIM                     (1994-98
data)

Residue file name: C:\Documents and Settings\aacierto\Desktop\DEEM-FCID
Files\2011\TepraloxydimChronic(food+water).R98

                                                 Adjustment factor #2
NOT used.

Analysis Date 06-16-2011/17:33:31     Residue file dated:
06-16-2011/17:32:23/8

Reference dose (RfD, Chronic) = .05 mg/kg bw/day

NOEL (Chronic) = 5 mg/kg bw/day

COMMENT 1: Dry bean and sunflower subgroup 20B

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg       Margin of  
Percent 

           Subgroup                       body wt/day   Exposure 1/  of
RfD 

--------------------------------------   -------------  ---------- 
---------

U.S. Population (total)                     0.001213        4,123       
2.4%

U.S. Population (spring season)             0.001203        4,157       
2.4%

U.S. Population (summer season)             0.001180        4,236       
2.4%

U.S. Population (autumn season)             0.001263        3,958       
2.5%

U.S. Population (winter season)             0.001202        4,160       
2.4%

Northeast region                            0.001203        4,157       
2.4%

Midwest region                              0.001256        3,981       
2.5%

Southern region                             0.001125        4,443       
2.3%

Western region                              0.001314        3,804       
2.6%

Hispanics                                   0.001489        3,357       
3.0%

Non-hispanic whites                         0.001151        4,343       
2.3%

Non-hispanic blacks                         0.001217        4,109       
2.4%

Non-hisp/non-white/non-black                0.001551        3,223       
3.1%

All infants (< 1 year)                      0.001761        2,840       
3.5%

Nursing infants                             0.000562        8,889       
1.1%

Non-nursing infants                         0.002216        2,257       
4.4%

Children 1-6  yrs                           0.003780        1,323       
7.6%

Children 7-12 yrs                           0.001961        2,549       
3.9%

Females 13-19 (not preg or nursing)         0.000904        5,534       
1.8%

Females 20+ (not preg or nursing)           0.000711        7,036       
1.4%

Females 13-50 yrs                           0.000893        5,601       
1.8%

Females 13+ (preg/not nursing)              0.001067        4,686       
2.1%

Females 13+ (nursing)                       0.001113        4,493       
2.2%

Males 13-19 yrs                             0.001262        3,962       
2.5%

Males 20+ yrs                               0.000849        5,890       
1.7%

Seniors 55+                                 0.000719        6,950       
1.4%

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Children 1-2 yrs                            0.004825        1,036       
9.6%

Children 3-5 yrs                            0.003404        1,469       
6.8%

Children 6-12 yrs                           0.002092        2,390       
4.2%

Youth 13-19 yrs                             0.001089        4,591       
2.2%

Adults 20-49 yrs                            0.000817        6,121       
1.6%

Adults 50+ yrs                              0.000721        6,933       
1.4%

Females 13-49 yrs                           0.000774        6,463       
1.5%

Tepraloxydim			Dietary-Exposure and Risk Assessment 	 		  DP #:  D384841

PC Code:121005

________________________________________________________________________
_____________________

 PAGE   

Page   PAGE  18  of   NUMPAGES  18 

