
                               \s \* MERGEFORMAT
                 UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
                            WASHINGTON, D.C.  20460


                                                     OFFICE OF CHEMICAL SAFETY 
                                                                                                     AND POLLUTION PREVENTION

MEMORANDUM

DATE:  	12/28/2010  

SUBJECT:	Fluoxastrobin:  Chronic Dietary (Food and Drinking Water) Exposure Assessments for the Section 3 Registration Action use on Squash/Cucumber Subgroup 9B.
	
PC Code:  028869
DP Barcode: 380847
Decision No.: 433137
Registration No.: 66330-64
Petition No.: NA
Regulatory Action: Section 3 Registration
Risk Assessment Type: Dietary
Case No.: NA
TXR No.: NA
CAS No.: 361377-29-9
MRID No.: NA
40 CFR:   §180.609

REVIEWER:	Cassi L. Walls, Ph.D, Senior Biologist
            Risk Assessment Branch III
            Health Effects Division (7509P)

THROUGH:	Mohsen Sahafeyan, Chemist 
		Donna Davis, Chemist
            Dietary Exposure Science Advisory Council (DESAC)
            Health Effects Division (7509P)
		
TO:		Nancy Tsaur, Risk Assessor
		Risk Assessment Branch III
		Health Effects Division (7509P)

		Tony Kish, RM Team #22 
		Registration Division (7505P)


Executive Summary
	
Chronic dietary (food and drinking water) exposure and risk assessments were conducted using the Dietary Exposure Evaluation Model (DEEM-FCID(TM), Version 2.03), which uses food consumption data from the U.S. Department of Agriculture's Continuing Surveys of Food Intakes by Individuals (CSFII) from 1994-1996 and 1998.  The analyses were performed to support new uses on crop subgroup 9B.

Acute Dietary Exposure Results and Characterization:  

No toxic effects attributable to a single exposure to fluoxastrobin have been identified; therefore, an acute reference dose (aRfD) has not been established and an acute dietary exposure assessment was not conducted.  
   
Chronic Dietary (Food and Drinking Water) Exposure Results and Characterization

A conservative dietary exposure assessment was performed for fluoxastrobin.  The assumptions of this dietary assessment included tolerance level residues and 100% crop treated (CT).  Estimated drinking water concentration (EDWC) values were also incorporated.  The estimated surface water concentration was incorporated directly into the dietary assessment using the 1-in-10 yr annual mean of 53 ug/L (DP379114, 384377).  The results of the chronic dietary analysis for food and drinking water are below the Agency's level of concern for all population subgroups.  The dietary exposure for food and water is estimated at 22% of the chronic Population Adjusted Dose (cPAD) for the general U.S. population and 47%, of the cPAD for children 1-2 yrs, the population subgroup with the highest estimated chronic dietary exposure to fluoxastrobin.

Cancer Dietary Exposure Results and Characterization

The Cancer Assessment Review Committee (CARC) recently concluded that fluoxastrobin is "not likely to be carcinogenic to humans;" therefore, cancer risk is not of concern. 

I.	Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide.  For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health effects).  This dose is referred to as the population adjusted dose (PAD).  The PAD is equivalent to the reference dose point of departure (POD, NOAEL, LOAEL) divided by the required uncertainty and safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD.  HED is generally concerned when estimated cancer risk exceeds one in one million.  References which discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site:  "Available Information on Assessing Exposure from Pesticides, A User's Guide," 6/21/2000, web link:  http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf; or see SOP 99.6 (8/20/99).

The last dietary risk assessment for fluoxastrobin was conducted by M. Negussie (01/22/2010, DP367050).  This dietary assessment is an update to the January 2010 fluoxastrobin dietary assessment to include the proposed new uses on squash/cucumber Subgroup 9B. 

II.     Residue Information

Fluoxastrobin is a fungicide used for the control of fungal diseases in tuberous and corm vegetables, fruiting vegetables, the leaf petiole vegetables, peanuts, sweet corn, wheat, as a seed treatment for potato and peanut, and as a soilborne/seedling disease control.  

The residues of concern in primary crops, rotational crops, and livestock, for tolerance enforcement and risk assessment are as follows: primary crops/rotational crops fluoxastrobin and its Z-isomer, livestock- fluoxastrobin, its Z-isomer and 6-(2-chlorophenoxy)-5-fluoro-4-pyrimidinol ( DP289106, W. Wassell, 01/25/2005).  Table 1 is a summary of the current food tolerances, Table 2 is a summary of pending tolerances, and Table 3 is a summary of the proposed tolerances for fluoxastrobin.
 
As stated above, Arysta is requesting the establishment of tolerances for fluoxastrobin for the new use on squash/cucumber Subgroup 9B.  HED recommends a food tolerance 0.50 ppm for residues of fluoxastrobin resulting from the proposed new use on squash/cucumbers (DP380846, M. Negussie, 11/17/2010).  

TABLE 1. 	Summary of Current Tolerances for Fluoxastrobin
Commodity 
                                Tolerance (ppm)
40 CFR §180.609(a)(1)
Berry, low growing, subgroup 13-07G
                                      1.9
Leaf petioles, subgroup 4B
                                      4.0
Soybean seed
                                     0.05
Tomato paste
                                      1.5
Vegetable, fruiting, group 8
                                      1.0
Vegetable, tuberous and corm, subgroup 1C
                                     0.01
40 CFR §180.609(a)(2)
Cattle, fat
Goat, fat
Horse, fat
Sheep, fat
                                     0.10
Cattle, meat
Goat, meat
Horse, meat
Sheep, meat
                                     0.05
Milk
                                     0.02
Milk, fat
                                     0.50


TABLE 2. 	Summary of Pending Tolerance for Fluoxastrobin
Commodity 
                                Tolerance (ppm)
40 CFR §180.609(a)(1)
Corn, sweet, kernels plus cobs with husks removed (K+CWHR)
                                     0.01
Wheat, grain
                                     0.09
Wheat, bran
                                     0.15
Peanut*
                                     0.02
Peanut, refined oil*
                                     0.06
40 CFR §180.609(a)(2)
Cattle, meat byproducts*
Goat, meat byproducts
Horse, meat byproducts
Sheep, meat byproducts
                                     0.20
* Note that the current 40 CFR §180.609(a)(1) and (2) lists different tolerances for these commodities.   The tolerances listed in this table differ because the registrant provided additional data and requested tolerances for new uses that can be fed to livestock which affected the livestock commodity residues.  These tolerances are still pending. Detailed information on these data can be found in the previous dietary assessment (DP367050, M. Negussie, 01/22/2010).

TABLE 3. 	Summary of Proposed Tolerance for Fluoxastrobin
Commodity 
                                Tolerance (ppm)
40 CFR §180.609(a)(1)
Squash/cucumber Subgroup 9B
                                     0.50

Residue Data used for Chronic Assessments:

Current, pending, and proposed tolerance level residues and 100% CT were used for all commodities included in the assessment.  Based on processing studies, the processing factors for tomato puree, potato, chips, dried potato (granules/flakes), and potato, flour were reduced to 1.  Separate tolerances were set for peanut oil, wheat bran and tomato paste; therefore, the processing factors for these commodities were set at 1 (DP289106, W.D. Wassell, 01/25/2005).  For all other processed commodities, DEEM version 7.81 default processing factors were assumed.  
 
Residue values used for chronic assessments are listed in Tables 1, 2, and 3 while the processing factors are listed in Table 4.

TABLE 4.     Processing Factors (PF) for Fluoxastrobin Dietary Risk Assessment.
                              Processed Commodity
                                      PF
                                    Source
Beef, meat, dried
                                     1.92
DEEM Default
Corn grain, sugar/hfcs
                                      1.5
DEEM Default
Cranberries, juice
                                      1.1
DEEM Default
Peanut, butter
                                     1.89
DEEM Default
Peanut, oil
                                      1.0
Tolerance for peanut, oil accounts for processing.
Potato, dried and flour
                                      1.0
Processing Study
Tomato, dried
                                     14.3
DEEM Default
Tomato, juice
                                      1.5
DEEM Default
Tomato, paste
                                      1.0
Tolerance for tomato, paste accounts for processing.
Tomato, puree
                                      1.0
Processing Study
Wheat, bran
                                      1.0
Tolerance for wheat, bran accounts for processing.

III.     Drinking Water Data
                                       
The drinking water residues used in the dietary risk assessment were provided by the Environmental Fate and Effects Division (EFED) (DP379114 and 384377, R. Bohaty, 12/15/10) and incorporated directly into this dietary assessment.  Water residues were incorporated in the DEEM-FCID into the food categories "water, direct, all sources" and "water, indirect, all sources."

Tier II EDWCs in surface water were estimated using PRZM/EXAMS while Tier I EDWCs in groundwater were estimated using the SCI-GROW Model.  The chronic Tier II EDWCs for the new use on squash/cucumbers are significantly lower (12 ug/L) than the exposures calculated based on the revised existing fluoxastrobin use on turf (53 ug/L).  The revised turf use provided the most conservative EDWC and was used in this assessment. 
										
Fluoxastrobin EDWCs were estimated using the turf use based on an application interval of 7 days and total application rate of 2.2 lb ai/A resulting from 4 applications of 0.55 lb ai/A.  The currently approved label and the proposed label for fluoxastrobin allow for a 7 day application interval on turf.  Table 5 provides an updated Tier II EDWCs for turf in surface water.  In the chronic analysis, the 1- in 10 year peak surface water value of 53 ppb was used.  The models and their descriptions are available at the EPA internet site: http://www.epa.gov/oppefed1/models/water/. 

TABLE 5.      Tier II EDWCs of Fluoxastrobin in surface water.

                                 Crop Scenario
         PRZM/EXAMS Estimated Concentrations in Surface Water (ug/L)
                                       
                       1-in-10 year Annual Peak (Acute)
                      1-in-10 year Annual Mean (Chronic)
                              30 year annual mean
                                   (Cancer)
Turf use
                                     60.7
                                     52.9
                                     23.5

							
IV.	DEEM-FCID(TM) Program and Consumption Information

Fluoxastrobin chronic dietary exposure assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM-FCID(TM), Version 2.03), which incorporates consumption data from USDA's Continuing Surveys of Food Intakes by Individuals (CSFII), 1994-1996 and 1998.  The 1994-96, 98 data are based on the reported consumption of more than 20,000 individuals over two non-consecutive survey days.  Foods "as consumed" (e.g., apple pie) are linked to EPA-defined food commodities (e.g. apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA.  For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups, but for acute exposure assessment are retained as individual consumption events.  Based on analysis of the 1994-96, 98 CSFII consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or food-form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food form to produce a residue intake estimate.  The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure.  Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD.  This procedure is performed for each population subgroup.

V.     Toxicological Information

The toxicity endpoints pertinent for human dietary risk assessment are summarized in Table 6.  

TABLE 6.  Summary of Toxicological Doses and Endpoints for Fluoxastrobin for Use in Dietary Exposure Risk Assessments
Exposure/
Scenario
                    Dose Used in Risk        Assessment, UF
FQPA SF and Endpoint for Risk Assessment
Study and Toxicological Effects
Acute Dietary (General Population)
No acute endpoint was identified for the general population.
Acute Dietary
(Females 13-49 years of age)


No acute endpoint was identified for females 13 to 49 years old.
Chronic Dietary all Populations
NOAEL = 1.5 mg/kg/day
UF = 100
Chronic RfD = 
0.015 mg/kg/day
FQPA SF = 1X
cPAD = chronic RfD
              FQPA SF
= 0.015 mg/kg/day
Chronic toxicity study with dogs.
LOAEL = M/F:8.1/7.7 mg/kg/day based on body weight reductions and hepatocytomegaly and cytoplasmic changes associated with increased serum liver alkaline phosphatase indicative of cholestasis.  

Cancer (oral, dermal, inhalation)   
Classification: Not likely to be carcinogenic to humans.
NOAEL = no observed adverse effect level.  LOAEL = lowest observed adverse effect level. UF = uncertainity factor.  FQPA SF = FQPA Safety Factor.  PAD = population adjusted dose (a = acute, c = chronic).  RfD = reference dose.  

VI.	Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the PAD.  The DEEM-FCID(TM) analyses estimate the dietary exposure of the U.S. population and various population subgroups.  The results reported in Table 7  are for the general U.S. Population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, females 13-49, adults 20-49, and adults 50+ years.  

Results of Chronic Dietary Exposure Analysis

The results of the aggregate chronic dietary analysis for food and drinking water are below the Agency's level of concern (<100% cPAD) for the general U.S. population (19% cPAD) and all population subgroups.  The most highly exposed population subgroup is children 1-2 yrs at 47% of the cPAD.  The results of the chronic dietary exposure analyses are reported in Table 7 below.


Table 7.  Result of Acute and Chronic Dietary Exposure and Risk Estimates for Fluoxastrobin
                              Population Subgroup
                                PAD, mg/kg/day
                             DEEM-FCID (food only)
                          DEEM-FCID (food and water)


                              Exposure, mg/kg/day
                                     % PAD
                              Exposure, mg/kg/day
                                     %PAD
                           Chronic Dietary Estimates
U.S. Population
                                       
                                       
                                       
                                       
                                     0.015
                           0.002154                
                                      14
                           0.003269                
                                      22
All infants (< 1 yr)
                                       
                           0.001470                 
                                      9.8
                           0.005125                
                                      34
Children 1-2 yrs
                                       
                           0.005323                
                                      36
                           0.006979                
                                      47
Children 3-5 yrs
                                       
                           0.004553                
                                      30
                           0.006103                
                                      41
Children 6-12 yrs
                                       
                           0.003055                
                                      20
                           0.004125                
                                      28
Youth 13-19 yrs
                                       
                           0.001914                
                                      13
                           0.002720                
                                      18
Adults 20-49 yrs
                                       
                           0.001780                
                                      12
                           0.002821                
                                      19
Adults 50+ yrs
                                       
                           0.001749                
                                      12
                           0.002844                
                                      19
Females 13-49 yrs
                                       
                           0.001728                
                                      12
                           0.002765                
                                      18

Cancer Dietary Exposure Results and Characterization

As noted above, the HED CARC has recently revisited the cancer classification for fluoxastrobin.  HED has reclassified fluoxastrobin as "not likely to be carcinogenic to humans," therefore cancer risk is not of concern. 

VIII.	Characterization of Inputs/Outputs

The chronic dietary risk assessment is conservative.  For this assessment, tolerance level residues and 100% CT were incorporated in the dietary analyses.  Based on processing studies, the processing factors for tomato puree, potato, chips, dried potato (granules/flakes), and potato, flour were reduced to 1.  Separate tolerances were set for peanut oil, wheat bran and tomato paste; therefore, the processing factors for these commodities were set at 1.  For all other processed commodities, DEEM version 7.81 default processing factors were assumed.  The assessment can be refined using percent crop treated information and monitoring data, however, since there are no risks of concern, additional refinement was not required.

Estimated drinking water concentrations for surface water were also incorporated.  The contribution of residues in drinking water to the dietary risk is minimal.  

IX.  	Conclusions

 Dietary risks for fluoxastrobin are below HED's level of concern for dietary exposure and risk.  Children 1-2 years old are the most highly exposed population subgroup for chronic exposure, with risks estimates at 47% of the cPAD.  Risks were lower for all other population subgroups, including the general U.S. population which has a %cPAD.  of 22%.  The chronic dietary exposure assessment is not likely to underestimate exposure.
 
  
X.	List of Attachments

Attachment 1.  Fluoxastrobin Chronic Dietary Analysis Input File - Food & Water
Attachment 2.  Fluoxastrobin Chronic Dietary Analysis Results - Food & Water
Attachment 3.  Fluoxastrobin Chronic Dietary Analysis Results - Food only

Filename: C:\Documents and Settings\cwalls\My Documents\Cassi\HED\Fluoxastrobin\Fluoxastrobin_tol+water_121510.R98
Chemical: Fluoxastrobin
RfD(Chronic): .015 mg/kg bw/day  NOEL(Chronic): 1.5 mg/kg bw/day
RfD(Acute): 0 mg/kg bw/day  NOEL(Acute):  0 mg/kg bw/day
Date created/last modified: 12-16-2010/15:27:05/8          Program ver. 2.03
Comment: proposed squash/cucumber use, new EDWC
-------------------------------------------------------------------------------
  EPA    Crop                                   Def Res     Adj.Factors   Comment
  Code    Grp  Commodity Name                    (ppm)       #1    #2   
-------- ---- -------------------------------  ----------  ------ ------  -----
01030150 1CD  Arrowroot, flour                   0.010000   1.000  1.000  
01030151 1CD  Arrowroot, flour-babyfood          0.010000   1.000  1.000  
01030170 1CD  Artichoke, Jerusalem               0.010000   1.000  1.000  
01030820 1CD  Cassava                            0.010000   1.000  1.000  
01030821 1CD  Cassava-babyfood                   0.010000   1.000  1.000  
01031390 1CD  Dasheen, corm                      0.010000   1.000  1.000  
01031660 1CD  Ginger                             0.010000   1.000  1.000  
01031661 1CD  Ginger-babyfood                    0.010000   1.000  1.000  
01031670 1CD  Ginger, dried                      0.010000   1.000  1.000  
01032960 1C   Potato, chips                      0.010000   1.000  1.000  
01032970 1C   Potato, dry (granules/ flakes)     0.010000   1.000  1.000  
01032971 1C   Potato, dry (granules/ flakes)-b   0.010000   1.000  1.000  
01032980 1C   Potato, flour                      0.010000   1.000  1.000  
01032981 1C   Potato, flour-babyfood             0.010000   1.000  1.000  
01032990 1C   Potato, tuber, w/peel              0.010000   1.000  1.000  
01032991 1C   Potato, tuber, w/peel-babyfood     0.010000   1.000  1.000  
01033000 1C   Potato, tuber, w/o peel            0.010000   1.000  1.000  
01033001 1C   Potato, tuber, w/o peel-babyfood   0.010000   1.000  1.000  
01033660 1CD  Sweet potato                       0.010000   1.000  1.000  
01033661 1CD  Sweet potato-babyfood              0.010000   1.000  1.000  
01033710 1CD  Tanier, corm                       0.010000   1.000  1.000  
01033870 1CD  Turmeric                           0.010000   1.000  1.000  
01034060 1CD  Yam, true                          0.010000   1.000  1.000  
01034070 1CD  Yam bean                           0.010000   1.000  1.000  
04020760 4B   Cardoon                            4.000000   1.000  1.000  
04020850 4B   Celery                             4.000000   1.000  1.000  
04020851 4B   Celery-babyfood                    4.000000   1.000  1.000  
04020860 4B   Celery, juice                      4.000000   1.000  1.000  
04020870 4B   Celtuce                            4.000000   1.000  1.000  
04021520 4B   Fennel, Florence                   4.000000   1.000  1.000  
04023220 4B   Rhubarb                            4.000000   1.000  1.000  
04023670 4B   Swiss chard                        4.000000   1.000  1.000  
06003470 6    Soybean, seed                      0.050000   1.000  1.000  
06003480 6    Soybean, flour                     0.050000   1.000  1.000  
06003481 6    Soybean, flour-babyfood            0.050000   1.000  1.000  
06003490 6    Soybean, soy milk                  0.050000   1.000  1.000  
06003491 6    Soybean, soy milk-babyfood or in   0.050000   1.000  1.000  
06003500 6    Soybean, oil                       0.050000   1.000  1.000  
06003501 6    Soybean, oil-babyfood              0.050000   1.000  1.000  
08001480 8    Eggplant                           1.000000   1.000  1.000  
08002340 8    Okra                               1.000000   1.000  1.000  
08002700 8    Pepper, bell                       1.000000   1.000  1.000  
08002701 8    Pepper, bell-babyfood              1.000000   1.000  1.000  
08002710 8    Pepper, bell, dried                1.000000   1.000  1.000  
08002711 8    Pepper, bell, dried-babyfood       1.000000   1.000  1.000  
08002720 8    Pepper, nonbell                    1.000000   1.000  1.000  
08002721 8    Pepper, nonbell-babyfood           1.000000   1.000  1.000  
08002730 8    Pepper, nonbell, dried             1.000000   1.000  1.000  
08003740 8    Tomatillo                          1.000000   1.000  1.000  
08003750 8    Tomato                             1.000000   1.000  1.000  
08003751 8    Tomato-babyfood                    1.000000   1.000  1.000  
08003760 8    Tomato, paste                      1.500000   1.000  1.000  
08003761 8    Tomato, paste-babyfood             1.500000   1.000  1.000  
08003770 8    Tomato, puree                      1.000000   1.000  1.000  
08003771 8    Tomato, puree-babyfood             1.000000   1.000  1.000  
08003780 8    Tomato, dried                      1.000000  14.300  1.000  
08003781 8    Tomato, dried-babyfood             1.000000  14.300  1.000  
08003790 8    Tomato, juice                      1.000000   1.500  1.000  
09020210 9B   Balsam pear                        0.500000   1.000  1.000  
09020880 9B   Chayote, fruit                     0.500000   1.000  1.000  
09021020 9B   Chinese waxgourd                   0.500000   1.000  1.000  
09021350 9B   Cucumber                           0.500000   1.000  1.000  
09023080 9B   Pumpkin                            0.500000   1.000  1.000  
09023090 9B   Pumpkin, seed                      0.500000   1.000  1.000  
09023560 9B   Squash, summer                     0.500000   1.000  1.000  
09023561 9B   Squash, summer-babyfood            0.500000   1.000  1.000  
09023570 9B   Squash, winter                     0.500000   1.000  1.000  
09023571 9B   Squash, winter-babyfood            0.500000   1.000  1.000  
13020570 13B  Blueberry                          1.900000   1.000  1.000  
13020571 13B  Blueberry-babyfood                 1.900000   1.000  1.000  
15001200 15   Corn, field, flour                 0.020000   1.000  1.000  
15001201 15   Corn, field, flour-babyfood        0.020000   1.000  1.000  
15001210 15   Corn, field, meal                  0.020000   1.000  1.000  
15001211 15   Corn, field, meal-babyfood         0.020000   1.000  1.000  
15001220 15   Corn, field, bran                  0.020000   1.000  1.000  
15001230 15   Corn, field, starch                0.020000   1.000  1.000  
15001231 15   Corn, field, starch-babyfood       0.020000   1.000  1.000  
15001240 15   Corn, field, syrup                 0.020000   1.500  1.000  
15001241 15   Corn, field, syrup-babyfood        0.020000   1.500  1.000  
15001250 15   Corn, field, oil                   0.020000   1.000  1.000  
15001251 15   Corn, field, oil-babyfood          0.020000   1.000  1.000  
15001270 15   Corn, sweet                        0.010000   1.000  1.000  DP#364
          Full comment: DP#364445
15001271 15   Corn, sweet-babyfood               0.010000   1.000  1.000  
15004010 15   Wheat, grain                       0.090000   1.000  1.000  DP#364
          Full comment: DP#364445
15004011 15   Wheat, grain-babyfood              0.090000   1.000  1.000  DP#364
          Full comment: DP#364445
15004020 15   Wheat, flour                       0.090000   1.000  1.000  DP#364
          Full comment: DP#364445
15004021 15   Wheat, flour-babyfood              0.090000   1.000  1.000  DP#364
          Full comment: DP#364445
15004030 15   Wheat, germ                        0.090000   1.000  1.000  DP#364
          Full comment: DP#364445
15004040 15   Wheat, bran                        0.150000   1.000  1.000  DP#364
          Full comment: DP#364445
21000440 M    Beef, meat                         0.050000   1.000  1.000  
21000441 M    Beef, meat-babyfood                0.050000   1.000  1.000  
21000450 M    Beef, meat, dried                  0.050000   1.920  1.000  
21000460 M    Beef, meat byproducts              0.200000   1.000  1.000  DP#364
          Full comment: DP#364445
21000461 M    Beef, meat byproducts-babyfood     0.200000   1.000  1.000  
21000470 M    Beef, fat                          0.100000   1.000  1.000  
21000471 M    Beef,fat-babyfood                  0.100000   1.000  1.000  
21000480 M    Beef, kidney                       0.200000   1.000  1.000  DP#364
          Full comment: DP#364445
21000490 M    Beef, liver                        0.200000   1.000  1.000  DP#364
          Full comment: DP#364445
21000491 M    Beef, liver-babyfood               0.200000   1.000  1.000  
23001690 M    Goat, meat                         0.050000   1.000  1.000  
23001700 M    Goat, meat byproducts              0.200000   1.000  1.000  DP#364
          Full comment: DP#364445
23001710 M    Goat, fat                          0.100000   1.000  1.000  
23001720 M    Goat, kidney                       0.200000   1.000  1.000  DP#364
          Full comment: DP#364445
23001730 M    Goat, liver                        0.200000   1.000  1.000  DP#364
          Full comment: DP#364445
24001890 M    Horse, meat                        0.050000   1.000  1.000  
26003390 M    Sheep, meat                        0.050000   1.000  1.000  
26003391 M    Sheep, meat-babyfood               0.050000   1.000  1.000  
26003400 M    Sheep, meat byproducts             0.200000   1.000  1.000  DP#364
          Full comment: DP#364445
26003410 M    Sheep, fat                         0.100000   1.000  1.000  
26003411 M    Sheep, fat-babyfood                0.100000   1.000  1.000  
26003420 M    Sheep, kidney                      0.200000   1.000  1.000  DP#364
          Full comment: DP#364445
26003430 M    Sheep, liver                       0.200000   1.000  1.000  DP#364
          Full comment: DP#364445
27002220 D    Milk, fat                          0.500000   1.000  1.000  
27002221 D    Milk, fat - baby food/infant for   0.500000   1.000  1.000  
27012230 D    Milk, nonfat solids                0.020000   1.000  1.000  
27012231 D    Milk, nonfat solids-baby food/in   0.020000   1.000  1.000  
27022240 D    Milk, water                        0.020000   1.000  1.000  
27022241 D    Milk, water-babyfood/infant form   0.020000   1.000  1.000  
27032251 D    Milk, sugar (lactose)-baby food/   0.020000   1.000  1.000  
86010000 O    Water, direct, all sources         0.052900   1.000  1.000  
86020000 O    Water, indirect, all sources       0.052900   1.000  1.000  
95001300 O    Cranberry                          1.900000   1.000  1.000  
95001301 O    Cranberry-babyfood                 1.900000   1.000  1.000  
95001310 O    Cranberry, dried                   1.900000   1.000  1.000  
95001320 O    Cranberry, juice                   1.900000   1.100  1.000  
95001321 O    Cranberry, juice-babyfood          1.900000   1.100  1.000  
95002630 O    Peanut                             0.020000   1.000  1.000  DP#364
          Full comment: DP#364445
95002640 O    Peanut, butter                     0.020000   1.890  1.000  DP#364
          Full comment: DP#364445
95002650 O    Peanut, oil                        0.060000   1.000  1.000  DP#364
          Full comment: DP#364445
95003590 O    Strawberry                         1.900000   1.000  1.000  
95003591 O    Strawberry-babyfood                1.900000   1.000  1.000  
95003600 O    Strawberry, juice                  1.900000   1.000  1.000  
95003601 O    Strawberry, juice-babyfood         1.900000   1.000  1.000  






U.S. Environmental Protection Agency                                 Ver. 2.00
DEEM-FCID Chronic analysis for FLUOXASTROBIN                    (1994-98 data)
Residue file name: C:\Documents and Settings\cwalls\My Documents\Cassi\HED\Fluoxastrobin\Fluoxastrobin_tol+water_121510.R98
                                                 Adjustment factor #2 NOT used.
Analysis Date 12-16-2010/15:30:21     Residue file dated: 12-16-2010/15:27:05/8
Reference dose (RfD, Chronic) = .015 mg/kg bw/day
COMMENT 1: proposed squash/cucumber use, new EDWC
===============================================================================
                    Total exposure by population subgroup
-------------------------------------------------------------------------------

                                                    Total Exposure
                                         -----------------------------------
          Population                         mg/kg             Percent of   
           Subgroup                       body wt/day             Rfd       
--------------------------------------   -------------       ---------------
U.S. Population (total)                     0.003269                21.8%

U.S. Population (spring season)             0.003304                22.0%
U.S. Population (summer season)             0.003440                22.9%
U.S. Population (autumn season)             0.003180                21.2%
U.S. Population (winter season)             0.003151                21.0%

Northeast region                            0.003289                21.9%
Midwest region                              0.003335                22.2%
Southern region                             0.002977                19.8%
Western region                              0.003646                24.3%

Hispanics                                   0.003765                25.1%
Non-hispanic whites                         0.003245                21.6%
Non-hispanic blacks                         0.002856                19.0%
Non-hisp/non-white/non-black                0.003669                24.5%

All infants (< 1 year)                      0.005125                34.2%
Nursing infants                             0.002053                13.7%
Non-nursing infants                         0.006291                41.9%
Children 1-6  yrs                           0.006259                41.7%
Children 7-12 yrs                           0.003916                26.1%

Females 13-19 (not preg or nursing)         0.002568                17.1%
Females 20+ (not preg or nursing)           0.002839                18.9%
Females 13-50 yrs                           0.002933                19.6%
Females 13+ (preg/not nursing)              0.003156                21.0%
Females 13+ (nursing)                       0.003543                23.6%

Males 13-19 yrs                             0.002860                19.1%
Males 20+ yrs                               0.002804                18.7%
Seniors 55+                                 0.002859                19.1%

Children 1-2 yrs                            0.006979                46.5%
Children 3-5 yrs                            0.006103                40.7%
Children 6-12 yrs                           0.004125                27.5%
Youth 13-19 yrs                             0.002720                18.1%
Adults 20-49 yrs                            0.002821                18.8%
Adults 50+ yrs                              0.002844                19.0%
Females 13-49 yrs                           0.002765                18.4%

-------------------------------------------------------------------------------

U.S. Environmental Protection Agency                                 Ver. 2.00
DEEM-FCID Chronic analysis for FLUOXASTROBIN                    (1994-98 data)
Residue file name: C:\Documents and Settings\cwalls\My Documents\Cassi\HED\Fluoxastrobin\Fluoxastrobin_tol_121510.R98
                                                 Adjustment factor #2 NOT used.
Analysis Date 12-28-2010/13:40:05     Residue file dated: 12-28-2010/13:39:07/8
Reference dose (RfD, Chronic) = .015 mg/kg bw/day
COMMENT 1: proposed squash/cucumber use; no water
===============================================================================
                    Total exposure by population subgroup
-------------------------------------------------------------------------------

                                                    Total Exposure
                                         -----------------------------------
          Population                         mg/kg             Percent of   
           Subgroup                       body wt/day             Rfd       
--------------------------------------   -------------       ---------------
U.S. Population (total)                     0.002154                14.4%

U.S. Population (spring season)             0.002199                14.7%
U.S. Population (summer season)             0.002242                14.9%
U.S. Population (autumn season)             0.002102                14.0%
U.S. Population (winter season)             0.002073                13.8%

Northeast region                            0.002272                15.1%
Midwest region                              0.002208                14.7%
Southern region                             0.001917                12.8%
Western region                              0.002368                15.8%

Hispanics                                   0.002500                16.7%
Non-hispanic whites                         0.002157                14.4%
Non-hispanic blacks                         0.001797                12.0%
Non-hisp/non-white/non-black                0.002302                15.3%

All infants (< 1 year)                      0.001470                 9.8%
Nursing infants                             0.000697                 4.6%
Non-nursing infants                         0.001763                11.8%
Children 1-6  yrs                           0.004701                31.3%
Children 7-12 yrs                           0.002903                19.4%

Females 13-19 (not preg or nursing)         0.001784                11.9%
Females 20+ (not preg or nursing)           0.001726                11.5%
Females 13-50 yrs                           0.001854                12.4%
Females 13+ (preg/not nursing)              0.002072                13.8%
Females 13+ (nursing)                       0.001999                13.3%

Males 13-19 yrs                             0.002040                13.6%
Males 20+ yrs                               0.001804                12.0%
Seniors 55+                                 0.001764                11.8%

Children 1-2 yrs                            0.005323                35.5%
Children 3-5 yrs                            0.004553                30.4%
Children 6-12 yrs                           0.003055                20.4%
Youth 13-19 yrs                             0.001914                12.8%
Adults 20-49 yrs                            0.001780                11.9%
Adults 50+ yrs                              0.001749                11.7%
Females 13-49 yrs                           0.001728                11.5%

-------------------------------------------------------------------------------

