  
                 UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
                            WASHINGTON, D.C.  20460


                                                      Office of Chemical Safety
                                                       and Pollution Prevention



MEMORANDUM

DATE:  	Nov 23, 2010

SUBJECT:	Thiamethoxam.  Acute and Chronic Aggregate Dietary (Food and Drinking Water) Exposure and Risk Assessments for the Section 3 Registration as a Seed Treatment for Alfalfa and Peanuts, and for Use in Food Handling Establishments.      

PC Code:  060109
DP Barcode:  D376368
Decision Number:  D424517 
Registration Numbers:  100-RGAL, 100-941, 1001306                              
Petition Numbers:  9F7657, 9F7707, 0F7734
Regulatory Action:  Section 3
                                 Registration
Assessment Type:  Dietary
Case Number:  7614
TXR Number:  NA
CAS Number:  153719-23-4
MRID Number:  NA
40CFR §180.565


REVIEWER:	Dennis McNeilly, Chemist
		Risk Assessment Branch II (RAB2)
            Health Effects Division (HED), 7509P

THROUGH:	Donna Davis, Chemist
		David Hrdy, Biologist
            Dietary Exposure Science Advisory Council (DESAC)
            Health Effects Division (HED), 7509P

TO:		Kable Davis/Venus Eagle, Team 01
		Insecticide/Rodenticide Branch
		Registration Division (RD), 7505P
Executive Summary

Acute and chronic aggregate dietary (food and drinking water) exposure and risk assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM-FCID(TM)), Version 2.03, which uses food consumption data from the US Department of Agriculture's Continuing Surveys of Food Intakes by Individuals (CSFII), collected from 1994 to 1996, and 1998.  These analyses were performed to support the Section 3 request for thiamethoxam use as a seed treatment for alfalfa and peanuts, and for the treatment of food handling establishments.

Tolerances for residues of thiamethoxam are listed in 40 CFR §180.565 and are expressed in terms of the combined residues of the insecticide thiamethoxam and its metabolite CGA-322704.  Thiamethoxam's major metabolite is CGA-322704, which is also the registered active ingredient clothianidin.  Clothianidin has a complete toxicological database and appears to have effects in mammals that are different from those of thiamethoxam.  Prior to receipt of the complete toxicity database for clothianidin, the Agency assumed, based on structural similarity, that the toxicity profile for clothianidin was equivalent to thiamethoxam, and conducted risk assessments on the combined thiamethoxam and clothianidin residues.  The Agency notes that the complete database has demonstrated that clothianidin does not have the same toxicity profile and residues of clothianidin need not be added to residues of thiamethoxam and compared to the thiamethoxam endpoints for risk assessment, instead separate dietary exposure and risk assessments should be conducted for thiamethoxam and clothianidin.  However, given the complexity of previous combined assessments, the Agency is continuing to include residues of clothianidin from thiamethoxam uses in the thiamethoxam risk assessment recognizing that this is an overestimate of risk.  Since risks for thiamethoxam using combined residue values are not of concern, it is not necessary at this time to revisit previous dietary inputs and separate out residues of the parent compound only.  A separate risk assessment which addresses risks from clothianidin residues resulting from the direct application of clothianidin as well as risks from residues of clothianidin coming from thiamethoxam uses is being conducted (Michael Doherty, D384145) concurrently to support the new uses that are the subject of this action.  

The acute assessment is based on tolerance level residues of thiamethoxam/clothianidin (the tolerance is for combined residues).  The chronic analysis is based on tolerance level/proposed tolerance levels and/or average field trial (D376367, W. Drew, 2 Nov 2010) residues and assumes 100% crop treated for all commodities.  For the chronic analysis, an anticipated residue of 0.01 ppm was used for residues in or on all commodities for which there are no existing or proposed thiamethoxam tolerances since the proposed new uses include food handling establishment use.  The assumption of 100% CT in these analyses (acute and chronic) results in a conservative assessment for thiamethoxam.  The analyses included direct incorporation of estimated thiamethoxam/clothianidin residues in drinking water.  Clothianidin is not a major degradate of thiamethoxam in water; therefore the water numbers reflect residues of the parent compound only.  For water, the highest estimate from conservative models was used for both the acute and the chronic dietary exposure analyses.

Based on these highly conservative assumptions, acute dietary (food and water) risk estimates at the 95th percentile of exposure are less than or equal to 9.5% of the acute population-adjusted dose (aPAD) for all population subgroups.  Chronic dietary (food and water) risk estimates are less than or equal to 43% of the chronic population-adjusted dose (cPAD) for all population subgroups.  Generally, HED is concerned when risk estimates exceed 100% of the PAD; therefore, all acute and chronic dietary risk estimates are below HED's level of concern (LOC).

These analyses indicate that there are no dietary exposure considerations that would preclude registration of thiamethoxam for the requested seed treatment uses on alfalfa and peanuts, and the treatment of food handling establishments.

1.	Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide.  For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (the dose which HED has concluded will result in no unreasonable adverse health effects).  This dose is referred to as the population adjusted dose (PAD).  The PAD is equivalent to the point of departure (POD), such as the NOAEL or LOAEL, divided by the requisite uncertainty and/or safety factors.  

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD.  References which discuss the acute and chronic risk assessments in more detail are available on the EPA pesticides web site, Available Information on Assessing Exposure from Pesticides, A User's Guide (21 June 2000), which can be accessed via the web link http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf (or see SOP 99.6, dated 8/20/1999).  

The most recent dietary risk assessment for thiamethoxam was conducted by D. McNeilly (D373595, 3 May 2010).

2.	Residue Information

Tolerances have been established for both thiamethoxam (40CFR §180.565) and clothianidin (40CFR §180.586) on a variety of commodities.  This assessment includes residue estimates associated with the requested Section 3 registration of thiamethoxam use as a seed treatment for alfalfa and peanuts, and for the thiamethoxam treatment of food handling establishments (see Table 2).  The residue of concern for this dietary risk assessment is thiamethoxan and its metabolite, clothianidin.

As discussed above, thiamethoxam's major metabolite is CGA-322704, which is also the registered active ingredient clothianidin.  Clothianidin has a complete toxicological database and appears to have effects in mammals that are different from those of thiamethoxam.  Prior to receipt of the complete toxicity database for clothianidin, the Agency assumed, based on structural similarity, that the toxicity profile for clothianidin was equivalent to thiamethoxam, and conducted risk assessments on the combined thiamethoxam and clothianidin residues.  The Agency notes that the complete database has demonstrated that clothianidin does not have the same toxicity profile and residues of clothianidin need not be added to residues of thiamethoxam and compared to the thiamethoxam endpoints for risk assessment, instead separate dietary exposure and risk assessments should be conducted for thiamethoxam and clothianidin.  However, given the complexity of previous combined assessments, the Agency is continuing to include residues of clothianidin from thiamethoxam uses in the thiamethoxam risk assessment recognizing that this is an overestimate of risk.  



Table 1.    HED-Recommended Tolerances for Thiamethoxam's Proposed Uses in/on Alfalfa, Peanuts and Food Handling Establishment Use.

Commodity
                           Proposed Tolerance (ppm)
                          Recommended Tolerance (ppm)
Comments; Correct Commodity Definition
                     Tolerances Proposed under 180.565(a)
Alfalfa, forage
                                     0.05
                                     0.05
Seed treatment
Alfalfa, hay
                                     0.12
                                     0.12
Seed treatment
Food Handling Est.
                                     0.01
                                     0.02

Peanut
                                     0.05
                                     0.05
Seed treatment
Peanut, hay
                                     0.25
                                     0.25
Seed treatment
Peanut, meal
                                     None
                                     0.15
Seed treatment


Acute Assessment

The acute assessment is based on tolerance level residues of thiamethoxam/clothianidin (the tolerance is for combined residues).  The drinking water estimate for the acute analysis provided in Table 2 includes residues of thiamethoxam from thiamethoxam uses, and is discussed in Section 3 below.  A complete listing of the residues and processing factors used in the acute analysis are included in Attachment 1. 

Chronic Assessment

Most of the inputs are derived from HED's June 30, 2009 review for thiamethoxam (D364256, Dennis McNeilly) and updated with anticipated residues for the proposed peanut and food handling establishment uses.  A complete listing of the residues and processing factors used in the chronic analysis are in Attachment 2.
 
The chronic assessment makes use of tolerance level residues (peanuts only), average residue values or the highest observed residue value from the thiamethoxam field trials.  Anticipated residues were evaluated for selected commodities only, which were listed in HED's dietary analyses for thiamethoxam (D364256, D. McNeilly, 30 June 2009) and to which are added the residue estimates for proposed uses on alfalfa, peanuts, and the food handling establishment treatment.   Although monitoring data are available for some commodities, field trial residues were used for all the uses, along with a high end estimate of drinking water residues.  Therefore this assessment is considered highly conservative.

Food Handling Establishments

The data supporting thiamethoxam use in food handling areas included a variety of food commodities exposed to thiamethoxam, in two different types of food handling establishments, at 1X the maximum proposed rate.  Based on maximum thiamethoxam and CGA-322704 residues of <0.01 ppm in food commodities exposed to 1X treatment in food handling areas (the majority of samples had non-detectable residues), HED recommends a tolerance of 0.02 ppm in food/feed commodities (other than those covered by a higher tolerance as a result of use on growing crops) and will use an anticipated residue of 0.01 ppm in DEEM.  All samples had residues values below the LOQ of <0.01, for both thiamethoxam and the metabolite CGA-322704 (combined LOQ = 0.02 ppm).      

Processing factors

There are no processed commodities associated with the proposed use on alfalfa or the use in food handling establishments.  The processed commodities associated with the proposed use on peanuts are peanut meal (an animal feed item) and refined oil.  Reduction of thiamethoxam residues in peanut oil after processing ranged from 0.22x -0.40x; an average processing factor of 0.31x will be used in DEEM.  

Empirical processing factors were used when available.  For food forms without empirical processing factors, DEEM 7.81 default values were used.  A complete listing of the empirical processing factors used can be found in Table 2 below.  Note:  Processing factors are not used and use of them would not be appropriate for residue estimates resulting from food handling establishment use.

Livestock 

HED has reevaluated the poultry dietary burden and determined that at the 1X feeding level, residues in poultry commodities would still be <LOQ.  HED concludes that residues in eggs and poultry meat, fat, and meat byproducts remain a 40CFR §180.6[a][3] situation (there is no expectation of finite residues in these commodities).  As a result, tolerances are still not required in any poultry commodities.

The dietary burden for cattle and/or swine have not increased significantly from those previously calculated.  Therefore, the current tolerances in livestock commodities are still appropriate and the residue estimates for livestock commodities are as recommended in the previous thiamethoxam risk assessment (D348703, M. Doherty, 25 Sept 2008).



         TABLE 2.  INPUT TABLE FOR SELECTED THIAMETHOXAM COMMODITIES.
                                       
RAC
Blending Classification
Data
Source
No. of
                                    Samples
No. of
Detectable
Residues
LOD or LOQ
(Avg. in PPM)
Reference
Processing
Factors (PF)[1]
Anticipated Residue Estimates/Tolerance








Chronic (Tol., AR)[2]
Artichoke, globe
NB/PB
FT
6
6
<0.02
D281702/
D325447
N/A
                                     0.19
Barley, grain
B
FT
16
10
<0.02
D281702/
D325447
(PF Ref -D281702)
0.3 pearled
0.3 bran
0.1 flour
                                     0.086
Brassica, head and stem, subgroup 5-A
NB/PB
FT (cabbage)
12
10
<0.02
D281702/
D325447
N/A
                                     0.98
Brassica, leafy greens, subgroup 5-B
NB/PB
FT
(mustard greens)
10
10
<0.02
D281702/
D325447
N/A
                                     0.82
Caneberry subgroup
13-A
PB
FT
12
12
<0.02
D281702/
D325447
N/A
                                     0.12
Citrus, fruits:
   Orange
   Grapefruit
   Lemon
NB/PB
FT

28
16
12

27
16
12
<0.02
D349272
0.6 oil
0.6 juice
                                     0.10
                                     0.07
                                     0.09
Food Handling Establishments
NA
FT
42
42
18[3]
8
<0.02
D376367
NA
                                     0.01
 Fruit, pome, group 11
 NB/PB
FT  (apple)
FT (pear)

26
12

26
10
<0.02
D281702/
D325447
& D265079
0.75 juice
                                     0.06
                                     0.06
Fruit, stone, group 12
  Cherry
  Peach
  Plum

PB
NB/PB
NB/PB

FT
FT
FT

20
20
20

20
19
8
<0.02

W. Cutchin, 12/10/03 DERs




1 prunes
                                       
                                     0.21
                                     0.07
                                     0.071
Grape
PB
FT
24
22
<0.02
D281702/
D325447
1.1 juice
                                     0.06
Grape, raisin
PB
FT (grape)
24
22
<0.02
D281702/
D325447
PF  -  D281702
2.3
                                     0.06
Peanut
B
FT
54
10
<0.02
D376367
0.31 oil
                                     0.05
Rice
B
FT
32
1
<0.02
D357449/
D357450
PF  -  D357449
0.9 
Polished rice
                                     0.01
Soybeans
B
FT
30
0
<0.02
D281702/
D325447
N/A
                                     0.01
Tree Nuts, group 14
PB
FT
12
0
<0.02
D349272
N/A
                                     0.01
Tropical Fruits
NB
FT (avocado)
10
2
<0.02
D357449/
D357450
N/A
                                     0.11
Vegetable, fruiting, group 8
Tomato
Pepper
NB/PB
FT
40
42

-
42

<0.02
<0.02
D281702/
D325447 +
D265079
PF  -  D265079
Tomato puree 1.7
Tomato paste 3.8
                                       
                                     0.08
                                     0.08
Vegetable, legume, group 6
B/PB

FT
Snap beans
Lima beans

16
10

0
0
<0.02
S. Tadayon,
26 Nov 2002
N/A
                                       
                                     0.01
                                     0.01
Vegetable, root, subgroup 1A
NB/PB
Tolerance
                                      N/A
D357449/
D357450
Potato chips 1.2
Potato flakes 1.7
                                     0.05
                                       
Water (direct, indirect)
N/A
EFED
N/A
N/A
N/A
N/A
N/A
 Acute=  0.13177  ppm      Chronic= 0.01131 ppm

1  -  The processing factors for existing uses are taken from HED's June 30, 2009 memo, the sources for these processing factors are cited in the
        reference column.   An average processing of 0.31 for peanut oil is the only new processing factor associated with the proposed new uses.
2  -  Anticipated residues were calculated using (1/2) LOQ for all values below the LOQ.
3- Separate analyses were conducted and reported for thiamethoxam and clothianidin.  Each compound has an LOQ of 0.01 ppm, with a combined LOQ of 0.02 ppm.
3.	Drinking Water Data

The drinking water residues used in these dietary risk assessments were provided by EFED (D373378, C. Kopert, 20 May 2010), and incorporated directly into the dietary assessments.  Water residues were incorporated in DEEM-FCID via entry into the food categories "water, direct, all sources" and "water, indirect, all sources."  The estimated drinking water concentrations (EDWCs) in surface water are 0.13177 ppm and 0.01131 ppm for acute and chronic scenarios, respectively.  Typically, HED uses the higher of the surface or groundwater estimates for each duration when assessing dietary risk, with the surface water (rice tail water) having higher values in this case.

The EDWCs were incorporated into the acute and chronic thiamethoxam assessments.  Clothianidin, a major metabolite of thiamethoxam in plants and livestock, is not a significant degradate of thiamethoxam in surface or groundwater sources of drinking water. 

A Tier II screening-level drinking water assessment was conducted for the proposed new use on peanut and alfalfa seeds.  EFED also evaluated leafy vegetables, dry bulb onions and corn because previous assessments on these commodities were conducted at a lower application rate.  
For surface water, the EDWCs for the crops modeled in this assessment did not exceed the previous EDWCs for rice reported in the previous drinking water assessment (D363202, F. Khan, 07 April 2009). The reported acute concentration of 131.77 ug/L, annual mean (chronic) concentration of 11.31 ug/L and the highest 30 year annual average concentration of 11.31 ug/L from the rice model are higher than the reported EDWCs for various uses in Table 3.  Therefore, the current EDWCs for surface water do not supersede the drinking water concentrations previously estimated for this chemical (D363202).
For groundwater, based on the proposed highest annual use rate for dry bulb onions (0.3 lbs ai/acre) and the proposed rates for peanut seed (0.08 lbs ai/acre) and alfalfa seed (0.022 lbs ai/acre), the SCI-GROW model concentrations of thiamethoxam were 4.66 ug/L, 1.24 ug/L, and 0.34 ug/L, respectively.  This value was compared to 4.14 ug/L reported for grapes in an earlier drinking water assessment (D329467) dated 10 January 2007.  Since 4.66 ug/L for dry bulb onions is greater than 4.14 ug/L, the current EDWC supercedes the previously recommended EDWC for groundwater.
The acute scenario EDWC in surface water (0.13177 ppm) was obtained via exposure modeling which utilized a modified Tier I Rice Model and the Provisional Cranberry Model.  This model and its description are available at the EPA internet website via the web link, http://www.epa.gov/oppefed1/models/water/.  


Table 3. Tier II Estimated Drinking Water Concentrations (EDWCs) resulting from applications of Thiamethoxam.
Drinking Water Source (model)
                                      Use
                                   Scenario 
                                (modeled rate)
                          1-in-10 year acute (ug/L)
                         1-in-10 year chronic (ug/L)
                           30- year average (ug/L)
Surface Water (PRZM/EXAMS)
NC Peanuts:
(1 app.1 X 0.08 lbs ai/acre)
                                     1.51
                                     0.16
                                     0.05

CA Alfalfa
(January  9)
MN Alfalfa
(May 25)
NC Alfalfa
(March 25)
PA Alfalfa
(March 9)
TX Alfalfa
(August 25)
IL Alfalfa
(May 25)
(all were 1 app. X 0.022 lbs. ai/acre)
                                     0.37
                                       
                                     0.27
                                       
                                     0.55
                                       
                                     0.37
                                       
                                     0.89
                                       
                                     0.58
                                     0.07
                                       
                                     0.03
                                       
                                     0.08
                                       
                                     0.05
                                       
                                     0.10
                                       
                                     0.06
                                     0.03
                                       
                                     0.02
                                       
                                     0.03
                                       
                                     0.03
                                       
                                     0.05
                                       
                                     0.03

Dry Bulb Onions:
CA Onion
GA Onion
(1 app. X 0.3 lbs ai/acre)

                                     1.57
                                     20.45
                                       
                                       
                                     0.25
                                     1.54
                                       
                                     0.06
                                     0.44

Leafy Vegetables:
CA Lettuce (1 run)
(1 app. X 0.266 lbs. ai/acre)
                                       
                                     23.78

                                     3.68
                                       
                                     1.29
Tail water 
(Rice Model)
Rice
(0.173 lbs ai/A/year)
                                  131.77[1,2]
                                  11.31[1,3]
                                  11.31[1,3]

Cranberry
(0.188 lbs ai/A/year)
                                   54.75[2]
                                    4.50[3]
                                    4.50[3]
Groundwater 
(SCI-GROW)
Peanuts:
(1 app. X 0.08 lbs ai/acre)
                                     1.24
                                     1.24
                                     1.24

Alfalfa:
(1 app. X 0.022 lbs. ai/acre)
                                     0.34
                                     0.34
                                     0.34

Dry bulb onions:
(1 app. X 0.30 lbs. ai/acre)
                                     4.66
                                     4.66
                                     4.66
Bold text denotes maximum estimated EDWC values.  All values adjusted with PCA factor of 0.87.
   1 Recommended EDWCs for surface water.
   2 EDWCs based on day 1.
   3 EWDCs based on average of 365 days.
   
Water Monitoring Data

Only very limited monitoring data are available for thiamethoxam and these data are discussed below; due to this limitation HED used modeling data for the drinking water residue estimate for both the acute and chronic dietary risk assessments.

Two small-scale prospective groundwater (PGW) monitoring studies were initiated in southwest Michigan in June 2001 and southwestern Georgia in the spring of 2002, to determine the potential for the active ingredient thiamethoxam and its degradates to reach groundwater when used in a vulnerable hydrogeologic setting. Analytical data were collected for 47 months (from treatment in the spring of 2001 until May 2005) in the Michigan study and for 36 months (from treatment in the spring of 2002 until May 2005) in the Georgia study.
      
In Michigan, thiamethoxam residues found in soil-pore water samples have clearly peaked and then declined. No quantifiable residues of thiamethoxam > LOQ (0.05 ppb) were observed in any of the 3, 6, and 9-ft lysimeters after the 36, 16, and 41-MAT sampling events, respectively. By the 47-MAT sampling event only trace level detections of thiamethoxam were observed in three of the 15-ft. lysimeter units (maximum concentration 0.11 ppb).

In Georgia, thiamethoxam residues have only been confirmed in four shallow monitoring wells (MW-1S, MW-3S, MW-5S, and MW-8S) during 47 months of sampling. Thiamethoxam residues in groundwater peaked at 43-MAT, and by 47-MAT residues were confined to two shallow monitoring wells only (maximum concentration 0.12 ppb). No detections of thiamethoxam at or greater than the analytical method LOQ have been observed in any groundwater samples collected from the deep monitoring wells during 47 months of sampling.

4.	DEEM-FCID(TM) Program and Consumption Information

Thiamethoxam acute and chronic dietary exposure assessments were conducted using DEEM-FCID(TM) (Version 2.03), which incorporates consumption data from USDA's CSFII, 1994 to 1996, and 1998.  The 1994-96, 1998 data are based on the reported consumption of more than 20,000 individuals over two non-consecutive survey days.  Foods "as consumed" (such as apple pie) are linked to EPA-defined food commodities (such as apples, peeled fruit - cooked, fresh/unspecified, or baked; or wheat flour - cooked, fresh/unspecified, or baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA.  For chronic exposure assessment, consumption data are averaged for the entire US population, and within population subgroups, but for acute exposure assessment, they are retained as individual consumption events (which is why it is appropriate to add residue values together for the acute assessment, while separate exposure estimates are summed for the chronic assessment).  Based on analysis of the 1994-96, 1998 CSFII consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general US population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50+ years old.  

For chronic dietary exposure assessment, an estimate of the residue level in each food or food-form (such as orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food form.  The resulting residue consumption estimate for each food/food form is summed with the residue consumption estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure.  Exposure is expressed in mg/kg body weight/day, and as a percent of the cPAD.  This procedure is performed for each population subgroup.  

For acute exposure assessments, individual one-day food consumption data are used on an individual-by-individual basis.  The reported consumption amounts of each food item can be multiplied by a residue point estimate, and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or "matched" in multiple random pairings with residue values, and then summed in a probabilistic assessment.  The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (those who reported eating relevant commodities/food forms) and a per-capita (those who reported eating the relevant commodities as well as those who did not) basis.  In accordance with HED policy, per capita exposure and risk are reported for all tiers of analysis.  However, for Tiers 1 and 2, significant differences in user versus per capita exposure and risk are identified, and noted in the risk assessment.  

5.	Toxicological Information

The toxicology database for thiamethoxam is complete.  The scientific quality is relatively high and the toxicity profile of thiamethoxam can be characterized for most effects, including potential carcinogenic, mutagenic, developmental, and neurotoxic effects.

 The Agency has determined that the 10X FQPA safety factor for the protection of infants and children can be reduced to 1X.  There is no quantitative or qualitative evidence of increased susceptibility of rat or rabbit fetuses to in utero exposure to thiamethoxam in the developmental toxicity studies.  The developmental NOAELs are either higher than or equal to the maternal NOAELs.  The Developmental Neurotoxity (DNT) Workgroup concluded there was no evidence of increased quantitative susceptibility in the DNT study in rats, based on evaluation of additional brain morphometric data for the low- and mid-dose pups (January 17, 2007 meeting).  
  
 Although there is evidence of increased quantitative susceptibility for male pups of both two generation reproductive studies, NOAELs and LOAELs were established in these studies, and the Agency selected the NOAEL for testicular effects in F1 pups as the basis for risk assessment.  The Agency is confident that the NOAEL selected for risk assessment is protective of the most sensitive effect (testicular effects) for the most sensitive subgroup (pups) observed in the toxicological database.    
 
In addition, the NOAELs selected for risk assessment are protective of all toxicological effects observed in the database including treatment-related changes in the adrenal gland, thyroid, testes and ovaries.  Thus, the Agency believes the FQPA safety factor can be reduced to 1X and still be conservatively protective of human health risk.


Table 4.  Toxicological Doses and Endpoints for Thiamethoxam for Use in Human Health Risk Assessments.

Exposure/
Scenario
Point of Departure
Uncertainty/ FQPA Safety Factors
Level of Concern for Risk Assessment
Study and Toxicological Effects
 Acute Dietary
All populations including infants and children 
 NOAEL =  34.5 mg/kg/day

UFA= 10x
UFH= 10x
SFFQPA=1
 
aRfD=0.35 mg/kg/day
aPAD=0.35 mg/kg/day
 Rat Developmental Neurotoxicity study 
LOAEL = 298.7 mg/kg/day based on delayed sexual maturation in male pups, and reduced brain morphometric measurements.
 Chronic Dietary
All populations including infants and children
NOAEL= 1.2 mg/kg/day 

(MRID 46402904) 
UFA= 10x
UFH= 10x
SFFQPA=1

cRfD=0.012 mg/kg/day
cPAD=0.012 mg/kg/day
 2-Generation reproduction study
 LOAEL = 1.8 mg/kg/day based on increased incidence and severity of tubular atrophy in testes of F1 generation males.
 
2-Generation reproduction study (46402904) 
LOAEL = 3 (males), not determined (females) mg/kg/day based on sperm abnormalities in F1 males.
 Cancer (oral, dermal, inhalation)
"Not Likely to be Carcinogenic to Humans" based on convincing evidence that a non-genotoxic mode of action for liver tumors was established in the mouse and that the carcinogenic effects are a result of a mode of action dependent on sufficient amounts of a hepatotoxic metabolite produced persistently.  Quantification of cancer risk is not required.   


6.	Results/Discussion

As previously stated, for acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the PAD.  The DEEM-FCID(TM) analyses estimate the dietary exposure of the US population and various population subgroups.   The results of the assessments are shown in Table 5, below.

                                       
Table 5.  Summary of Estimated Dietary (Food + Drinking Water) Exposures and Risk for Thiamethoxam.
                                       
Population Subgroup
                                aPAD, mg/kg/day
                    Acute Estimates (95[th] Percentile)[1]
                                cPAD, mg/kg/day
                               Chronic Estimates

                                       
                              Exposure, mg/kg/day
                                 Risk, % aPAD
                                       
                              Exposure, mg/kg/day
                                 Risk, % cPAD
U.S. Population
                                     0.35
0.018094
5.2
                                     0.012
0.002825
24
All infants (< 1 year)[2]
                                     0.35
0.033165
9.5
                                     0.012
0.003052
25
Children 1-2 yrs
                                     0.35
0.032947
9.4
                                     0.012
0.005150
43
Children 3-5 yrs
                                     0.35
0.026627
7.6
                                     0.012
0.004520
38
Children 6-12 yrs
                                     0.35
0.018819
5.4
                                     0.012
0.003241
27
Youth 13-19 yrs
                                     0.35
0.014311
4.1
                                     0.012
0.002333
19
Adults 20-49 yrs
                                     0.35
0.016277
4.7
                                     0.012
0.002591
22
Adults 50+ yrs
                                     0.35
0.016617
4.8
                                     0.012
0.002648
22
Females 13-49 yrs
                                     0.35
0.16123
4.6
                                     0.012
0.002617
22
1  -  Results for the 99[th] and 99.9[th] percentile are reported in Attachment 3. 
2  -  The population subgroup with the highest estimated exposure/risk is bolded.

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the PAD.  The DEEM-FCID(TM) analyses estimate the dietary exposure of the U.S. population and various population subgroups.  The results reported in Table 5 are for the general U.S. population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, females 13-49, adults 20-49, and adults 50+ years.  The acute results summarized in Table 6 are for the 95[th] percentile of exposure.  A complete listing of acute and chronic exposure and risk estimates can be found in Attachments 2 and 3, respectively.

The analyses indicate that the requested uses of thiamethoxam, coupled with currently registered uses, will result in acute and chronic dietary (food + drinking water) exposures that are below HED's level of concern for all population subgroups, including those of infants and children.

Typically, HED uses tolerance-level residues in its most conservative assessments.  For this reason, the acute assessment is considered to be an unrefined assessment (i.e., screening level) and evaluation at the 95[th] percentile of exposure is appropriate.  The acute assessment indicates that All Infants are the most highly-exposed subgroup, utilizing 9.5% of the aPAD, while the general US population utilizes 5.2% of the aPAD; all risk estimates are below HED's level of concern (Table 5).  Similarly, risk estimates for the chronic dietary exposure analysis are below HED's level of concern, with Children 1-2 years being the most highly-exposed subgroup, utilizing 43% of the chronic population-adjusted dose (cPAD), while the general U.S. population utilizes 24% of the cPAD.

 7.	Characterization of Inputs/Outputs

This assessment is based on tolerance level or anticipated residues derived from field trial residue data and assumes 100% CT.  The exposure values represent high-end estimates and should be considered highly conservative, health-protective estimates of dietary exposure and risk.  The Tier I Rice Model used to generate the EDWCs is expected to generate conservative estimates that exceed peak measured concentrations of pesticides in water bodies well downstream of rice paddies by less than one order of magnitude to multiple orders of magnitude.
 
 8.	Conclusions

Based on highly conservative assumptions, there are no dietary (food + drinking water) exposure considerations that would preclude registration of thiamethoxam on alfalfa, peanuts and/or use in food handling establishments.
 
 
 9.	List of Attachments
 
Attachment 1.  Input file for the acute dietary exposure analyses of thiamethoxam.
Attachment 2.  Input file for the chronic dietary exposure analyses of thiamethoxam.
Attachment 3.  Summary of the acute dietary exposure analysis for thiamethoxam.
Attachment 4.  Summary of the chronic dietary exposure analysis for thiamethoxam.
 
 Attachment 1.	Input File for the Acute Dietary Exposure Estimates.

U.S. Environmental Protection Agency                                 Ver. 2.02
DEEM-FCID Acute analysis for THIAMETHOXAM
Residue file name: C:\Documents and Settings\dmcneill\My Documents\Thiamethoxam_3\060109 2010 Acute T+Water.R98
Analysis Date 10-28-2010             Residue file dated: 10-28-2010/09:42:38
Reference dose (aRfD) = 0.35 mg/kg bw/day
Comment: Acute and Chronic RfDs = aPAD and cPAD
--------------------------------------------------------------------------------
  EPA    Crop                                   Def Res     Adj.Factors   Comment
  Code    Grp  Food Name                         (ppm)       #1    #2   
-------- ---- -------------------------------  ----------  ------ ------  -------
14000030 14   Almond                             0.020000   1.000  1.000
14000031 14   Almond-babyfood                    0.020000   1.000  1.000
14000040 14   Almond, oil                        0.020000   1.000  1.000
14000041 14   Almond, oil-babyfood               0.020000   1.000  1.000
04010050 4A   Amaranth, leafy                    4.000000   1.000  1.000
11000070 11   Apple, fruit with peel             0.200000   1.000  1.000
11000080 11   Apple, peeled fruit                0.200000   1.000  1.000
11000081 11   Apple, peeled fruit-babyfood       0.200000   1.000  1.000
11000090 11   Apple, dried                       0.200000   8.000  1.000
11000091 11   Apple, dried-babyfood              0.200000   8.000  1.000
11000100 11   Apple, juice                       0.200000   0.750  1.000
11000101 11   Apple, juice-babyfood              0.200000   0.750  1.000
11000110 11   Apple, sauce                       0.200000   1.000  1.000
11000111 11   Apple, sauce-babyfood              0.200000   1.000  1.000
12000120 12   Apricot                            0.500000   1.000  1.000
12000121 12   Apricot-babyfood                   0.500000   1.000  1.000
12000130 12   Apricot, dried                     0.500000   6.000  1.000
12000140 12   Apricot, juice                     0.500000   1.000  1.000
12000141 12   Apricot, juice-babyfood            0.500000   1.000  1.000
95000160 O    Artichoke, globe                   0.450000   1.000  1.000
04010180 4A   Arugula                            4.000000   1.000  1.000
95000200 O    Avocado                            0.400000   1.000  1.000
09020210 9B   Balsam pear                        0.200000   1.000  1.000
15000250 15   Barley, pearled barley             0.300000   0.300  1.000
          Full comment: D281702
15000251 15   Barley, pearled barley-babyfood    0.300000   0.300  1.000
          Full comment: D281702
15000260 15   Barley, flour                      0.300000   0.100  1.000
          Full comment: D281702
15000261 15   Barley, flour-babyfood             0.300000   0.100  1.000
          Full comment: D281702
15000270 15   Barley, bran                       0.300000   0.300  1.000
          Full comment: D281702
06030300 6C   Bean, black, seed                  0.020000   1.000  1.000
06020310 6B   Bean, broad, succulent             0.020000   1.000  1.000
06030320 6C   Bean, broad, seed                  0.020000   1.000  1.000
06020330 6B   Bean, cowpea, succulent            0.020000   1.000  1.000
06030340 6C   Bean, cowpea, seed                 0.020000   1.000  1.000
06030350 6C   Bean,  great northern, seed        0.020000   1.000  1.000
06030360 6C   Bean, kidney, seed                 0.020000   1.000  1.000
06020370 6B   Bean, lima, succulent              0.020000   1.000  1.000
06030380 6C   Bean, lima, seed                   0.020000   1.000  1.000
06030390 6C   Bean, mung, seed                   0.020000   1.000  1.000
06030400 6C   Bean, navy, seed                   0.020000   1.000  1.000
06030410 6C   Bean, pink, seed                   0.020000   1.000  1.000
06030420 6C   Bean, pinto, seed                  0.020000   1.000  1.000
06010430 6A   Bean, snap, succulent              0.020000   1.000  1.000
06010431 6A   Bean, snap, succulent-babyfood     0.020000   1.000  1.000
21000440 M    Beef, meat                         0.020000   1.000  1.000
21000441 M    Beef, meat-babyfood                0.020000   1.000  1.000
21000450 M    Beef, meat, dried                  0.020000   1.920  1.000
21000460 M    Beef, meat byproducts              0.040000   1.000  1.000
21000461 M    Beef, meat byproducts-babyfood     0.040000   1.000  1.000
21000480 M    Beef, kidney                       0.040000   1.000  1.000
21000490 M    Beef, liver                        0.040000   1.000  1.000
21000491 M    Beef, liver-babyfood               0.040000   1.000  1.000
01010500 1AB  Beet, garden, roots                0.050000   1.000  1.000
          Full comment: D357449, recommended tol.
01010501 1AB  Beet, garden, roots-babyfood       0.050000   1.000  1.000
01010520 1A   Beet, sugar                        0.050000   1.000  1.000
01010521 1A   Beet, sugar-babyfood               0.050000   1.000  1.000
01010530 1A   Beet, sugar, molasses              0.050000   1.000  1.000
01010531 1A   Beet, sugar, molasses-babyfood     0.050000   1.000  1.000
13010550 13A  Blackberry                         0.350000   1.000  1.000
13010560 13A  Blackberry, juice                  0.350000   1.000  1.000
13010561 13A  Blackberry, juice-babyfood         0.350000   1.000  1.000
13020570 13B  Blueberry                          0.300000   1.000  1.000
13020571 13B  Blueberry-babyfood                 0.300000   1.000  1.000
13010580 13A  Boysenberry                        0.350000   1.000  1.000
14000590 14   Brazil nut                         0.020000   1.000  1.000
05010610 5A   Broccoli                           4.500000   1.000  1.000
05010611 5A   Broccoli-babyfood                  4.500000   1.000  1.000
05010620 5A   Broccoli, Chinese                  4.500000   1.000  1.000
05020630 5B   Broccoli raab                      3.000000   1.000  1.000
05010640 5A   Brussels sprouts                   4.500000   1.000  1.000
15000650 15   Buckwheat                          0.020000   1.000  1.000
15000660 15   Buckwheat, flour                   0.020000   1.000  1.000
01010670 1AB  Burdock                            0.050000   1.000  1.000
14000680 14   Butternut                          0.020000   1.000  1.000
05010690 5A   Cabbage                            4.500000   1.000  1.000
05020700 5B   Cabbage, Chinese, bok choy         3.000000   1.000  1.000
05010710 5A   Cabbage, Chinese, napa             4.500000   1.000  1.000
05010720 5A   Cabbage, Chinese, mustard          4.500000   1.000  1.000
95000740 O    Canistel                           0.400000   1.000  1.000
09010750 9A   Cantaloupe                         0.200000   1.000  1.000
04020760 4B   Cardoon                            4.000000   1.000  1.000
01010780 1AB  Carrot                             0.050000   1.000  1.000
01010781 1AB  Carrot-babyfood                    0.050000   1.000  1.000
01010790 1AB  Carrot, juice                      0.050000   1.000  1.000
09010800 9A   Casaba                             0.200000   1.000  1.000
14000810 14   Cashew                             0.020000   1.000  1.000
05010830 5A   Cauliflower                        4.500000   1.000  1.000
01010840 1AB  Celeriac                           0.050000   1.000  1.000
04020850 4B   Celery                             4.000000   1.000  1.000
04020851 4B   Celery-babyfood                    4.000000   1.000  1.000
04020860 4B   Celery, juice                      4.000000   1.000  1.000
04020870 4B   Celtuce                            4.000000   1.000  1.000
09020880 9B   Chayote, fruit                     0.200000   1.000  1.000
95000890 O    Cherimoya                          0.110000   1.000  1.000
12000900 12   Cherry                             0.500000   1.000  1.000
12000901 12   Cherry-babyfood                    0.500000   1.000  1.000
12000910 12   Cherry, juice                      0.500000   1.500  1.000
12000911 12   Cherry, juice-babyfood             0.500000   1.500  1.000
14000920 14   Chestnut                           0.020000   1.000  1.000
06030980 6C   Chickpea, seed                     0.020000   1.000  1.000
06030981 6C   Chickpea, seed-babyfood            0.020000   1.000  1.000
06030990 6C   Chickpea, flour                    0.020000   1.000  1.000
01011000 1AB  Chicory, roots                     0.050000   1.000  1.000
09021020 9B   Chinese waxgourd                   0.200000   1.000  1.000
04011040 4A   Chrysanthemum, garland             4.000000   1.000  1.000
10001060 10   Citrus citron                      0.400000   1.000  1.000
          Full comment: D348703
10001070 10   Citrus hybrids                     0.400000   1.000  1.000
10001080 10   Citrus, oil                        0.400000   0.600  1.000
          Full comment: D349272
95001150 O    Coffee, roasted bean               0.050000   1.000  1.000
95001160 O    Coffee, instant                    0.050000   1.000  1.000
05021170 5B   Collards                           3.000000   1.000  1.000
15001200 15   Corn, field, flour                 0.020000   1.000  1.000
15001201 15   Corn, field, flour-babyfood        0.020000   1.000  1.000
15001210 15   Corn, field, meal                  0.020000   1.000  1.000
15001211 15   Corn, field, meal-babyfood         0.020000   1.000  1.000
15001220 15   Corn, field, bran                  0.020000   1.000  1.000
15001230 15   Corn, field, starch                0.020000   1.000  1.000
15001231 15   Corn, field, starch-babyfood       0.020000   1.000  1.000
15001240 15   Corn, field, syrup                 0.020000   1.500  1.000
15001241 15   Corn, field, syrup-babyfood        0.020000   1.500  1.000
15001250 15   Corn, field, oil                   0.020000   1.000  1.000
15001251 15   Corn, field, oil-babyfood          0.020000   1.000  1.000
15001260 15   Corn, pop                          0.020000   1.000  1.000
15001270 15   Corn, sweet                        0.020000   1.000  1.000
15001271 15   Corn, sweet-babyfood               0.020000   1.000  1.000
95001280 O    Cottonseed, oil                    0.100000   1.000  1.000
95001281 O    Cottonseed, oil-babyfood           0.100000   1.000  1.000
11001290 11   Crabapple                          0.200000   1.000  1.000
95001300 O    Cranberry                          0.020000   1.000  1.000
95001301 O    Cranberry-babyfood                 0.020000   1.000  1.000
95001310 O    Cranberry, dried                   0.020000   1.000  1.000
95001320 O    Cranberry, juice                   0.020000   1.100  1.000
95001321 O    Cranberry, juice-babyfood          0.020000   1.100  1.000
04011330 4A   Cress, garden                      4.000000   1.000  1.000
04011340 4A   Cress, upland                      4.000000   1.000  1.000
09021350 9B   Cucumber                           0.200000   1.000  1.000
13021360 13B  Currant                            0.200000   1.000  1.000
13021370 13B  Currant, dried                     0.200000   1.000  1.000
04011380 4A   Dandelion, leaves                  4.000000   1.000  1.000
13011420 13A  Dewberry                           0.350000   1.000  1.000
08001480 8    Eggplant                           0.250000   1.000  1.000
13021490 13B  Elderberry                         0.200000   1.000  1.000
04011500 4A   Endive                             4.000000   1.000  1.000
04021520 4B   Fennel, Florence                   4.000000   1.000  1.000
14001550 14   Filbert                            0.020000   1.000  1.000
14001560 14   Filbert, oil                       0.020000   1.000  1.000
20001630 20   Flaxseed, oil                      0.020000   1.000  1.000
01011680 1AB  Ginseng, dried                     0.050000   1.000  1.000
23001690 M    Goat, meat                         0.020000   1.000  1.000
23001700 M    Goat, meat byproducts              0.040000   1.000  1.000
23001720 M    Goat, kidney                       0.040000   1.000  1.000
23001730 M    Goat, liver                        0.040000   1.000  1.000
13021740 13B  Gooseberry                         0.200000   1.000  1.000
95001750 O    Grape                              0.200000   1.000  1.000
95001760 O    Grape, juice                       0.200000   1.100  1.000
          Full comment: D281702
95001761 O    Grape, juice-babyfood              0.200000   1.100  1.000
95001770 O    Grape, leaves                      0.200000   1.000  1.000
95001780 O    Grape, raisin                      0.200000   2.300  1.000
          Full comment: D281702
95001790 O    Grape, wine and sherry             0.200000   1.000  1.000
10001800 10   Grapefruit                         0.400000   1.000  1.000
10001810 10   Grapefruit, juice                  0.400000   0.600  1.000
          Full comment: D349272
06031820 6C   Guar, seed                         0.020000   1.000  1.000
06031821 6C   Guar, seed-babyfood                0.020000   1.000  1.000
14001850 14   Hickory nut                        0.020000   1.000  1.000
09011870 9A   Honeydew melon                     0.200000   1.000  1.000
95001880 O    Hop                                0.100000   1.000  1.000
24001890 M    Horse, meat                        0.020000   1.000  1.000
01011900 1AB  Horseradish                        0.050000   1.000  1.000
13021910 13B  Huckleberry                        0.200000   1.000  1.000
05021940 5B   Kale                               3.000000   1.000  1.000
05011960 5A   Kohlrabi                           4.500000   1.000  1.000
10001970 10   Kumquat                            0.400000   1.000  1.000
10001990 10   Lemon                              0.400000   1.000  1.000
10002000 10   Lemon, juice                       0.400000   0.600  1.000
          Full comment: D348272
10002001 10   Lemon, juice-babyfood              0.400000   0.600  1.000
          Full comment: D349272
10002010 10   Lemon, peel                        0.400000   1.000  1.000
06032030 6C   Lentil, seed                       0.020000   1.000  1.000
04012040 4A   Lettuce, head                      4.000000   1.000  1.000
04012050 4A   Lettuce, leaf                      4.000000   1.000  1.000
10002060 10   Lime                               0.400000   1.000  1.000
10002070 10   Lime, juice                        0.400000   0.600  1.000
          Full comment: D348272
10002071 10   Lime, juice-babyfood               0.400000   0.600  1.000
          Full comment: D349272
13012080 13A  Loganberry                         0.350000   1.000  1.000
11002100 11   Loquat                             0.200000   1.000  1.000
14002130 14   Macadamia nut                      0.020000   1.000  1.000
95002150 O    Mango                              0.400000   1.000  1.000
95002151 O    Mango-babyfood                     0.400000   1.000  1.000
95002160 O    Mango, dried                       0.400000   1.000  1.000
95002170 O    Mango, juice                       0.400000   1.000  1.000
95002171 O    Mango, juice-babyfood              0.400000   1.000  1.000
28002210 M    Meat, game                         0.020000   1.000  1.000
27002220 D    Milk, fat                          0.020000   1.000  1.000
27002221 D    Milk, fat - baby food/infant for   0.020000   1.000  1.000
27012230 D    Milk, nonfat solids                0.020000   1.000  1.000
27012231 D    Milk, nonfat solids-baby food/in   0.020000   1.000  1.000
27022240 D    Milk, water                        0.020000   1.000  1.000
27022241 D    Milk, water-babyfood/infant form   0.020000   1.000  1.000
27032251 D    Milk, sugar (lactose)-baby food/   0.020000   1.000  1.000
15002260 15   Millet, grain                      0.020000   1.000  1.000
05022290 5B   Mustard greens                     3.000000   1.000  1.000
12002300 12   Nectarine                          0.500000   1.000  1.000
15002310 15   Oat, bran                          0.020000   1.000  1.000
15002320 15   Oat, flour                         0.020000   1.000  1.000
15002321 15   Oat, flour-babyfood                0.020000   1.000  1.000
15002330 15   Oat, groats/rolled oats            0.020000   1.000  1.000
15002331 15   Oat, groats/rolled oats-babyfood   0.020000   1.000  1.000
08002340 8    Okra                               0.250000   1.000  1.000
03002370 3    Onion, dry bulb                    0.030000   1.000  1.000
03002371 3    Onion, dry bulb-babyfood           0.030000   1.000  1.000
03002380 3    Onion, dry bulb, dried             0.030000   9.000  1.000
03002381 3    Onion, dry bulb, dried-babyfood    0.030000   9.000  1.000
10002400 10   Orange                             0.400000   1.000  1.000
10002410 10   Orange, juice                      0.400000   0.600  1.000
          Full comment: D349272
10002411 10   Orange, juice-babyfood             0.400000   0.600  1.000
          Full comment: D348272
10002420 10   Orange, peel                       0.400000   1.000  1.000
95002450 O    Papaya                             0.400000   1.000  1.000
95002451 O    Papaya-babyfood                    0.400000   1.000  1.000
95002460 O    Papaya, dried                      0.400000   1.800  1.000
95002470 O    Papaya, juice                      0.400000   1.500  1.000
04012480 4A   Parsley, leaves                    4.000000   1.000  1.000
01012500 1AB  Parsley, turnip rooted             0.050000   1.000  1.000
01012510 1AB  Parsnip                            0.050000   1.000  1.000
01012511 1AB  Parsnip-babyfood                   0.050000   1.000  1.000
06022550 6B   Pea, succulent                     0.020000   1.000  1.000
06022551 6B   Pea, succulent-babyfood            0.020000   1.000  1.000
06032560 6C   Pea, dry                           0.020000   1.000  1.000
06032561 6C   Pea, dry-babyfood                  0.020000   1.000  1.000
06012570 6A   Pea, edible podded, succulent      0.020000   1.000  1.000
06032580 6C   Pea, pigeon, seed                  0.020000   1.000  1.000
06022590 6B   Pea, pigeon, succulent             0.020000   1.000  1.000
12002600 12   Peach                              0.500000   1.000  1.000
12002601 12   Peach-babyfood                     0.500000   1.000  1.000
12002610 12   Peach, dried                       0.500000   7.000  1.000
12002611 12   Peach, dried-babyfood              0.500000   7.000  1.000
12002620 12   Peach, juice                       0.500000   1.000  1.000
12002621 12   Peach, juice-babyfood              0.500000   1.000  1.000
95002630 O    Peanut                             0.050000   1.000  1.000
95002640 O    Peanut, butter                     0.050000   1.890  1.000
95002650 O    Peanut, oil                        0.050000   0.310  1.000
          Full comment: D376367
11002660 11   Pear                               0.200000   1.000  1.000
11002661 11   Pear-babyfood                      0.200000   1.000  1.000
11002670 11   Pear, dried                        0.200000   6.250  1.000
11002680 11   Pear, juice                        0.200000   1.000  1.000
11002681 11   Pear, juice-babyfood               0.200000   1.000  1.000
14002690 14   Pecan                              0.020000   1.000  1.000
08002700 8    Pepper, bell                       0.250000   1.000  1.000
08002701 8    Pepper, bell-babyfood              0.250000   1.000  1.000
08002710 8    Pepper, bell, dried                0.250000   1.000  1.000
08002711 8    Pepper, bell, dried-babyfood       0.250000   1.000  1.000
08002720 8    Pepper, nonbell                    0.250000   1.000  1.000
08002721 8    Pepper, nonbell-babyfood           0.250000   1.000  1.000
08002730 8    Pepper, nonbell, dried             0.250000   1.000  1.000
95002750 O    Peppermint                         1.500000   1.000  1.000
95002760 O    Peppermint, oil                    1.500000   0.050  1.000
14002820 14   Pistachio                          0.020000   1.000  1.000
12002850 12   Plum                               0.500000   1.000  1.000
12002851 12   Plum-babyfood                      0.500000   1.000  1.000
12002860 12   Plum, prune, fresh                 0.500000   1.000  1.000
12002861 12   Plum, prune, fresh-babyfood        0.500000   1.000  1.000
12002870 12   Plum, prune, dried                 0.500000   5.000  1.000
12002871 12   Plum, prune, dried-babyfood        0.500000   5.000  1.000
12002880 12   Plum, prune, juice                 0.500000   1.400  1.000
12002881 12   Plum, prune, juice-babyfood        0.500000   1.400  1.000
25002900 M    Pork, meat                         0.020000   1.000  1.000
25002901 M    Pork, meat-babyfood                0.020000   1.000  1.000
25002920 M    Pork, meat byproducts              0.020000   1.000  1.000
25002921 M    Pork, meat byproducts-babyfood     0.020000   1.000  1.000
25002940 M    Pork, kidney                       0.020000   1.000  1.000
25002950 M    Pork, liver                        0.020000   1.000  1.000
01032960 1C   Potato, chips                      0.250000   1.200  1.000
01032970 1C   Potato, dry (granules/ flakes)     0.250000   1.700  1.000
01032971 1C   Potato, dry (granules/ flakes)-b   0.250000   1.700  1.000
01032980 1C   Potato, flour                      0.250000   1.700  1.000
01032981 1C   Potato, flour-babyfood             0.250000   1.700  1.000
01032990 1C   Potato, tuber, w/peel              0.250000   1.000  1.000
01032991 1C   Potato, tuber, w/peel-babyfood     0.250000   1.000  1.000
01033000 1C   Potato, tuber, w/o peel            0.250000   1.000  1.000
01033001 1C   Potato, tuber, w/o peel-babyfood   0.250000   1.000  1.000
10003070 10   Pummelo                            0.400000   1.000  1.000
09023080 9B   Pumpkin                            0.200000   1.000  1.000
09023090 9B   Pumpkin, seed                      0.200000   1.000  1.000
11003100 11   Quince                             0.200000   1.000  1.000
29003120 M    Rabbit, meat                       0.020000   1.000  1.000
04013130 4A   Radicchio                          4.000000   1.000  1.000
01013140 1AB  Radish, roots                      0.050000   1.000  1.000
02003150 2    Radish, tops                       0.800000   1.000  1.000
01013160 1AB  Radish, Oriental, roots            0.050000   1.000  1.000
02003170 2    Radish, Oriental, tops             0.800000   1.000  1.000
05023180 5B   Rape greens                        3.000000   1.000  1.000
20003190 20   Rapeseed, oil                      0.020000   1.000  1.000
20003191 20   Rapeseed, oil-babyfood             0.020000   1.000  1.000
13013200 13A  Raspberry                          0.350000   1.000  1.000
13013201 13A  Raspberry-babyfood                 0.350000   1.000  1.000
13013210 13A  Raspberry, juice                   0.350000   1.000  1.000
13013211 13A  Raspberry, juice-babyfood          0.350000   1.000  1.000
04023220 4B   Rhubarb                            4.000000   1.000  1.000
15003230 15   Rice, white                        0.020000   1.000  1.000
15003231 15   Rice, white-babyfood               0.020000   1.000  1.000
15003240 15   Rice, brown                        0.020000   1.000  1.000
15003241 15   Rice, brown-babyfood               0.020000   1.000  1.000
15003250 15   Rice, flour                        0.020000   1.000  1.000
15003251 15   Rice, flour-babyfood               0.020000   1.000  1.000
15003260 15   Rice, bran                         0.020000   0.900  1.000
          Full comment: D357449
15003261 15   Rice, bran-babyfood                0.020000   0.900  1.000
          Full comment: D357449
01013270 1AB  Rutabaga                           0.050000   1.000  1.000
15003280 15   Rye, grain                         0.020000   1.000  1.000
15003290 15   Rye, flour                         0.020000   1.000  1.000
20003300 20   Safflower, oil                     0.020000   1.000  1.000
20003301 20   Safflower, oil-babyfood            0.020000   1.000  1.000
01013310 1AB  Salsify, roots                     0.050000   1.000  1.000
95003330 O    Sapote, Mamey                      0.400000   1.000  1.000
26003390 M    Sheep, meat                        0.020000   1.000  1.000
26003391 M    Sheep, meat-babyfood               0.020000   1.000  1.000
26003400 M    Sheep, meat byproducts             0.040000   1.000  1.000
26003420 M    Sheep, kidney                      0.040000   1.000  1.000
26003430 M    Sheep, liver                       0.040000   1.000  1.000
15003440 15   Sorghum, grain                     0.020000   1.000  1.000
15003450 15   Sorghum, syrup                     0.020000   1.000  1.000
06003470 6    Soybean, seed                      0.020000   1.000  1.000
06003480 6    Soybean, flour                     0.020000   1.000  1.000
06003481 6    Soybean, flour-babyfood            0.020000   1.000  1.000
06003490 6    Soybean, soy milk                  0.020000   1.000  1.000
06003491 6    Soybean, soy milk-babyfood or in   0.020000   1.000  1.000
06003500 6    Soybean, oil                       0.020000   1.000  1.000
06003501 6    Soybean, oil-babyfood              0.020000   1.000  1.000
95003520 O    Spearmint                          1.500000   1.000  1.000
95003530 O    Spearmint, oil                     1.500000   0.050  1.000
          Full comment: D281702
04013550 4A   Spinach                            4.000000   1.000  1.000
04013551 4A   Spinach-babyfood                   4.000000   1.000  1.000
09023560 9B   Squash, summer                     0.200000   1.000  1.000
09023561 9B   Squash, summer-babyfood            0.200000   1.000  1.000
09023570 9B   Squash, winter                     0.200000   1.000  1.000
09023571 9B   Squash, winter-babyfood            0.200000   1.000  1.000
95003590 O    Strawberry                         0.300000   1.000  1.000
95003591 O    Strawberry-babyfood                0.300000   1.000  1.000
95003600 O    Strawberry, juice                  0.300000   1.000  1.000
95003601 O    Strawberry, juice-babyfood         0.300000   1.000  1.000
20003640 20   Sunflower, seed                    0.020000   1.000  1.000
20003650 20   Sunflower, oil                     0.020000   1.000  1.000
20003651 20   Sunflower, oil-babyfood            0.020000   1.000  1.000
01033660 1CD  Sweet potato                       0.020000   1.000  1.000
01033661 1CD  Sweet potato-babyfood              0.020000   1.000  1.000
04023670 4B   Swiss chard                        4.000000   1.000  1.000
10003690 10   Tangerine                          0.400000   1.000  1.000
10003700 10   Tangerine, juice                   0.400000   0.600  1.000
          Full comment: D348272
01033710 1CD  Tanier, corm                       0.020000   1.000  1.000
08003740 8    Tomatillo                          0.250000   1.000  1.000
08003750 8    Tomato                             0.250000   1.000  1.000
08003751 8    Tomato-babyfood                    0.250000   1.000  1.000
08003760 8    Tomato, paste                      0.800000   1.000  1.000 Tol.
08003761 8    Tomato, paste-babyfood             0.800000   1.000  1.000 Tol.
08003770 8    Tomato, puree                      0.250000   1.700  1.000
08003771 8    Tomato, puree-babyfood             0.250000   1.700  1.000
08003780 8    Tomato, dried                      0.250000  14.300  1.000
08003781 8    Tomato, dried-babyfood             0.250000  14.300  1.000
08003790 8    Tomato, juice                      0.250000   1.500  1.000
15003810 15   Triticale, flour                   0.020000   1.000  1.000
15003811 15   Triticale, flour-babyfood          0.020000   1.000  1.000
01033870 1CD  Turmeric                           0.020000   1.000  1.000
01013880 1AB  Turnip, roots                      0.050000   1.000  1.000
05023890 5B   Turnip, greens                     3.000000   1.000  1.000
14003910 14   Walnut                             0.020000   1.000  1.000
86010000 O    Water, direct, all sources         0.131770   1.000  1.000
          Full comment: D373378
86020000 O    Water, indirect, all sources       0.131770   1.000  1.000
          Full comment: D373378
09013990 9A   Watermelon                         0.200000   1.000  1.000
09014000 9A   Watermelon, juice                  0.200000   1.000  1.000
15004010 15   Wheat, grain                       0.020000   1.000  1.000
15004011 15   Wheat, grain-babyfood              0.020000   1.000  1.000
15004020 15   Wheat, flour                       0.020000   1.000  1.000
15004021 15   Wheat, flour-babyfood              0.020000   1.000  1.000
15004030 15   Wheat, germ                        0.020000   1.000  1.000
15004040 15   Wheat, bran                        0.020000   1.000  1.000
15004050 15   Wild rice                          0.020000   1.000  1.000
01034060 1CD  Yam, true                          0.020000   1.000  1.000
01034070 1CD  Yam bean                           0.020000   1.000  1.000Attachment 2.	Input File for the Chronic Dietary Exposure Estimates.

U.S. Environmental Protection Agency                                 Ver. 2.00
DEEM-FCID Chronic analysis for THIAMETHOXAM                       1994-98 data
Residue file: C:\Documents and Settings\dmcneill\My Documents\Thiamethoxam_3\060109 2010 T+FHE+Water.R98
                                                           Adjust. #2 NOT used
Analysis Date 09-28-2010             Residue file dated: 09-28-2010/14:20:28/8
Reference dose (RfD) = 0.012 mg/kg bw/day
Comment:Acute and Chronic RfDs = aPAD and cPAD
--------------------------------------------------------------------------------
Food Crop                                       Residue       Adj.Factors      Comment
EPA Code  Grp  Food Name                          (ppm)       
                                                             #1         #2 
-------- ---- -------------------------------   ---------- ------     ------   -------
95000010 O    Acerola                            0.010000   1.000      1.000   FHE
18000020 18   Alfalfa, seed                      0.010000   1.000      1.000   FHE
14000030 14   Almond                             0.010000   1.000      1.000   D34927
  Full comment: D349272
14000031 14   Almond-babyfood                    0.010000   1.000      1.000   
14000040 14   Almond, oil                        0.010000   1.000      1.000   
14000041 14   Almond, oil-babyfood               0.010000   1.000      1.000   
04010050 4A   Amaranth, leafy                    4.000000   1.000      1.000   
95000060 O    Amaranth, grain                    0.010000   1.000      1.000   FHE
11000070 11   Apple, fruit with peel             0.060000   1.000      1.000   D28170
  Full comment: D281702 & D265079
11000080 11   Apple, peeled fruit                0.060000   1.000      1.000   
11000081 11   Apple, peeled fruit-babyfood       0.060000   1.000      1.000   
11000090 11   Apple, dried                       0.060000   8.000      1.000   
11000091 11   Apple, dried-babyfood              0.060000   8.000      1.000   
11000100 11   Apple, juice                       0.060000   0.750      1.000   
11000101 11   Apple, juice-babyfood              0.060000   0.750      1.000   
11000110 11   Apple, sauce                       0.060000   1.000      1.000   
11000111 11   Apple, sauce-babyfood              0.060000   1.000      1.000   
12000120 12   Apricot                            0.210000   1.000      1.000   W. Cut
  Full comment: W. Cuthchin 12/10/03 DERs
12000121 12   Apricot-babyfood                   0.210000   1.000      1.000   
12000130 12   Apricot, dried                     0.210000   6.000      1.000   
12000140 12   Apricot, juice                     0.210000   1.000      1.000   
12000141 12   Apricot, juice-babyfood            0.210000   1.000      1.000   
01030150 1CD  Arrowroot, flour                   0.010000   1.000      1.000   FHE
01030151 1CD  Arrowroot, flour-babyfood          0.010000   1.000      1.000   FHE
95000160 O    Artichoke, globe                   0.190000   1.000      1.000   D28170
  Full comment: D281702/D325447
01030170 1CD  Artichoke, Jerusalem               0.010000   1.000      1.000   FHE
04010180 4A   Arugula                            4.000000   1.000      1.000   
95000190 O    Asparagus                          0.010000   1.000      1.000   FHE
95000200 O    Avocado                            0.110000   1.000      1.000   D35744
  Full comment: D357449/D357450
09020210 9B   Balsam pear                        0.200000   1.000      1.000   
95000220 O    Bamboo, shoots                     0.010000   1.000      1.000   FHE
95000230 O    Banana                             0.010000   1.000      1.000   FHE
95000231 O    Banana-babyfood                    0.010000   1.000      1.000   FHE
95000240 O    Banana, dried                      0.010000   1.000      1.000   FHE
95000241 O    Banana, dried-babyfood             0.010000   1.000      1.000   FHE
15000250 15   Barley, pearled barley             0.086000   0.300      1.000   D28170
  Full comment: D281702/D325447
15000251 15   Barley, pearled barley-babyfood    0.086000   0.300      1.000   
15000260 15   Barley, flour                      0.086000   0.100      1.000   
15000261 15   Barley, flour-babyfood             0.086000   0.100      1.000   
15000270 15   Barley, bran                       0.086000   0.300      1.000   
19010280 19A  Basil, fresh leaves                0.010000   1.000      1.000   FHE
19010281 19A  Basil, fresh leaves-babyfood       0.010000   1.000      1.000   FHE
19010290 19A  Basil, dried leaves                0.010000   1.000      1.000   FHE
19010291 19A  Basil, dried leaves-babyfood       0.010000   1.000      1.000   FHE
06030300 6C   Bean, black, seed                  0.010000   1.000      1.000   S,. Ta
  Full comment: S,. Tayayin, 26 Nov 2002
06020310 6B   Bean, broad, succulent             0.010000   1.000      1.000   
06030320 6C   Bean, broad, seed                  0.010000   1.000      1.000   
06020330 6B   Bean, cowpea, succulent            0.010000   1.000      1.000   
06030340 6C   Bean, cowpea, seed                 0.010000   1.000      1.000   
06030350 6C   Bean,  great northern, seed        0.010000   1.000      1.000   
06030360 6C   Bean, kidney, seed                 0.010000   1.000      1.000   
06020370 6B   Bean, lima, succulent              0.010000   1.000      1.000   
06030380 6C   Bean, lima, seed                   0.010000   1.000      1.000   
06030390 6C   Bean, mung, seed                   0.010000   1.000      1.000   
06030400 6C   Bean, navy, seed                   0.010000   1.000      1.000   
06030410 6C   Bean, pink, seed                   0.010000   1.000      1.000   
06030420 6C   Bean, pinto, seed                  0.010000   1.000      1.000   
06010430 6A   Bean, snap, succulent              0.010000   1.000      1.000   
06010431 6A   Bean, snap, succulent-babyfood     0.010000   1.000      1.000   
21000440 M    Beef, meat                         0.020000   1.000      1.000   
21000441 M    Beef, meat-babyfood                0.020000   1.000      1.000   
21000450 M    Beef, meat, dried                  0.020000   1.920      1.000   
21000460 M    Beef, meat byproducts              0.040000   1.000      1.000   Rec. T
  Full comment: Rec. Tol.
21000461 M    Beef, meat byproducts-babyfood     0.040000   1.000      1.000   
21000470 M    Beef, fat                          0.010000   1.000      1.000   FHE
21000471 M    Beef,fat-babyfood                  0.010000   1.000      1.000   FHE
21000480 M    Beef, kidney                       0.040000   1.000      1.000   
21000490 M    Beef, liver                        0.040000   1.000      1.000   
21000491 M    Beef, liver-babyfood               0.040000   1.000      1.000   
01010500 1AB  Beet, garden, roots                0.050000   1.000      1.000   
01010501 1AB  Beet, garden, roots-babyfood       0.050000   1.000      1.000   
02000510 2    Beet, garden, tops                 0.010000   1.000      1.000   FHE
01010520 1A   Beet, sugar                        0.050000   1.000      1.000   
01010521 1A   Beet, sugar-babyfood               0.050000   1.000      1.000   
01010530 1A   Beet, sugar, molasses              0.050000   1.000      1.000   
01010531 1A   Beet, sugar, molasses-babyfood     0.050000   1.000      1.000   
95000540 O    Belgium endive                     0.010000   1.000      1.000   FHE
13010550 13A  Blackberry                         0.120000   1.000      1.000   D28170
  Full comment: D281702
13010560 13A  Blackberry, juice                  0.120000   1.000      1.000   
13010561 13A  Blackberry, juice-babyfood         0.120000   1.000      1.000   
13020570 13B  Blueberry                          0.300000   1.000      1.000   
13020571 13B  Blueberry-babyfood                 0.300000   1.000      1.000   
13010580 13A  Boysenberry                        0.120000   1.000      1.000   
14000590 14   Brazil nut                         0.010000   1.000      1.000   
95000600 O    Breadfruit                         0.010000   1.000      1.000   FHE
05010610 5A   Broccoli                           0.980000   1.000      1.000   D28170
  Full comment: D281702
05010611 5A   Broccoli-babyfood                  0.980000   1.000      1.000   
05010620 5A   Broccoli, Chinese                  0.980000   1.000      1.000   
05020630 5B   Broccoli raab                      0.820000   1.000      1.000   
05010640 5A   Brussels sprouts                   0.980000   1.000      1.000   
15000650 15   Buckwheat                          0.020000   1.000      1.000   
15000660 15   Buckwheat, flour                   0.020000   1.000      1.000   
01010670 1AB  Burdock                            0.050000   1.000      1.000   
14000680 14   Butternut                          0.010000   1.000      1.000   
05010690 5A   Cabbage                            0.980000   1.000      1.000   
05020700 5B   Cabbage, Chinese, bok choy         0.820000   1.000      1.000   D28170
  Full comment: D281702
05010710 5A   Cabbage, Chinese, napa             0.980000   1.000      1.000   
05010720 5A   Cabbage, Chinese, mustard          0.980000   1.000      1.000   
95000730 O    Cactus                             0.010000   1.000      1.000   FHE
95000740 O    Canistel                           0.400000   1.000      1.000   
09010750 9A   Cantaloupe                         0.200000   1.000      1.000   
04020760 4B   Cardoon                            4.000000   1.000      1.000   
95000770 O    Carob                              0.010000   1.000      1.000   FHE
01010780 1AB  Carrot                             0.050000   1.000      1.000   
01010781 1AB  Carrot-babyfood                    0.050000   1.000      1.000   
01010790 1AB  Carrot, juice                      0.050000   1.000      1.000   
09010800 9A   Casaba                             0.200000   1.000      1.000   
14000810 14   Cashew                             0.010000   1.000      1.000   
01030820 1CD  Cassava                            0.010000   1.000      1.000   FHE
01030821 1CD  Cassava-babyfood                   0.010000   1.000      1.000   FHE
05010830 5A   Cauliflower                        0.980000   1.000      1.000   
01010840 1AB  Celeriac                           0.050000   1.000      1.000   
04020850 4B   Celery                             4.000000   1.000      1.000   
04020851 4B   Celery-babyfood                    4.000000   1.000      1.000   
04020860 4B   Celery, juice                      4.000000   1.000      1.000   
04020870 4B   Celtuce                            4.000000   1.000      1.000   
09020880 9B   Chayote, fruit                     0.200000   1.000      1.000   
95000890 O    Cherimoya                          0.110000   1.000      1.000   
12000900 12   Cherry                             0.210000   1.000      1.000   
12000901 12   Cherry-babyfood                    0.210000   1.000      1.000   
12000910 12   Cherry, juice                      0.210000   1.500      1.000   
12000911 12   Cherry, juice-babyfood             0.210000   1.500      1.000   
14000920 14   Chestnut                           0.010000   1.000      1.000   
40000930 P    Chicken, meat                      0.010000   1.000      1.000   FHE
40000931 P    Chicken, meat-babyfood             0.010000   1.000      1.000   FHE
40000940 P    Chicken, liver                     0.010000   1.000      1.000   FHE
40000950 P    Chicken, meat byproducts           0.010000   1.000      1.000   FHE
40000951 P    Chicken, meat byproducts-babyfoo   0.010000   1.000      1.000   FHE
40000960 P    Chicken, fat                       0.010000   1.000      1.000   FHE
40000961 P    Chicken, fat-babyfood              0.010000   1.000      1.000   FHE
40000970 P    Chicken, skin                      0.010000   1.000      1.000   FHE
40000971 P    Chicken, skin-babyfood             0.010000   1.000      1.000   FHE
06030980 6C   Chickpea, seed                     0.010000   1.000      1.000   
06030981 6C   Chickpea, seed-babyfood            0.010000   1.000      1.000   
06030990 6C   Chickpea, flour                    0.010000   1.000      1.000   
01011000 1AB  Chicory, roots                     0.050000   1.000      1.000   
02001010 2    Chicory, tops                      0.010000   1.000      1.000   FHE
09021020 9B   Chinese waxgourd                   0.200000   1.000      1.000   
19011030 19A  Chive                              0.010000   1.000      1.000   FHE
04011040 4A   Chrysanthemum, garland             4.000000   1.000      1.000   
19021050 19B  Cinnamon                           0.010000   1.000      1.000   FHE
19021051 19B  Cinnamon-babyfood                  0.010000   1.000      1.000   FHE
10001060 10   Citrus citron                      0.100000   1.000      1.000   
10001070 10   Citrus hybrids                     0.100000   1.000      1.000   
10001080 10   Citrus, oil                        0.100000   0.600      1.000   
95001090 O    Cocoa bean, chocolate              0.010000   1.000      1.000   FHE
95001100 O    Cocoa bean, powder                 0.010000   1.000      1.000   FHE
95001110 O    Coconut, meat                      0.010000   1.000      1.000   FHE
95001111 O    Coconut- meat-babyfood             0.010000   1.000      1.000   FHE
95001120 O    Coconut, dried                     0.010000   1.000      1.000   FHE
95001130 O    Coconut, milk                      0.010000   1.000      1.000   FHE
95001140 O    Coconut, oil                       0.010000   1.000      1.000   FHE
95001141 O    Coconut, oil-babyfood              0.010000   1.000      1.000   FHE
95001150 O    Coffee, roasted bean               0.050000   1.000      1.000   
95001160 O    Coffee, instant                    0.050000   1.000      1.000   
05021170 5B   Collards                           0.820000   1.000      1.000   
19011180 19A  Coriander, leaves                  0.010000   1.000      1.000   FHE
19011181 19A  Coriander, leaves-babyfood         0.010000   1.000      1.000   FHE
19021190 19B  Coriander, seed                    0.010000   1.000      1.000   FHE
19021191 19B  Coriander, seed-babyfood           0.010000   1.000      1.000   FHE
15001200 15   Corn, field, flour                 0.020000   1.000      1.000   
15001201 15   Corn, field, flour-babyfood        0.020000   1.000      1.000   
15001210 15   Corn, field, meal                  0.020000   1.000      1.000   
15001211 15   Corn, field, meal-babyfood         0.020000   1.000      1.000   
15001220 15   Corn, field, bran                  0.020000   1.000      1.000   
15001230 15   Corn, field, starch                0.020000   1.000      1.000   
15001231 15   Corn, field, starch-babyfood       0.020000   1.000      1.000   
15001240 15   Corn, field, syrup                 0.020000   1.500      1.000   
15001241 15   Corn, field, syrup-babyfood        0.020000   1.500      1.000   
15001250 15   Corn, field, oil                   0.020000   1.000      1.000   
15001251 15   Corn, field, oil-babyfood          0.020000   1.000      1.000   
15001260 15   Corn, pop                          0.020000   1.000      1.000   
15001270 15   Corn, sweet                        0.020000   1.000      1.000   
15001271 15   Corn, sweet-babyfood               0.020000   1.000      1.000   
95001280 O    Cottonseed, oil                    0.100000   1.000      1.000   
95001281 O    Cottonseed, oil-babyfood           0.100000   1.000      1.000   
11001290 11   Crabapple                          0.060000   1.000      1.000   
95001300 O    Cranberry                          0.020000   1.000      1.000   
95001301 O    Cranberry-babyfood                 0.020000   1.000      1.000   
95001310 O    Cranberry, dried                   0.020000   1.000      1.000   
95001320 O    Cranberry, juice                   0.020000   1.100      1.000   
95001321 O    Cranberry, juice-babyfood          0.020000   1.100      1.000   
04011330 4A   Cress, garden                      4.000000   1.000      1.000   
04011340 4A   Cress, upland                      4.000000   1.000      1.000   
09021350 9B   Cucumber                           0.200000   1.000      1.000   
13021360 13B  Currant                            0.200000   1.000      1.000   
13021370 13B  Currant, dried                     0.200000   1.000      1.000   
04011380 4A   Dandelion, leaves                  4.000000   1.000      1.000   
01031390 1CD  Dasheen, corm                      0.010000   1.000      1.000   FHE
02001400 2    Dasheen, leaves                    0.010000   1.000      1.000   FHE
95001410 O    Date                               0.010000   1.000      1.000   FHE
13011420 13A  Dewberry                           0.120000   1.000      1.000   
19021430 19B  Dill, seed                         0.010000   1.000      1.000   FHE
19011440 19A  Dillweed                           0.010000   1.000      1.000   FHE
70001450 P    Egg, whole                         0.010000   1.000      1.000   FHE
70001451 P    Egg, whole-babyfood                0.010000   1.000      1.000   FHE
70001460 P    Egg, white                         0.010000   1.000      1.000   FHE
70001461 P    Egg, white (solids)-babyfood       0.010000   1.000      1.000   FHE
70001470 P    Egg, yolk                          0.010000   1.000      1.000   FHE
70001471 P    Egg, yolk-babyfood                 0.010000   1.000      1.000   FHE
08001480 8    Eggplant                           0.080000   1.000      1.000   D28170
  Full comment: D281702, tomato
13021490 13B  Elderberry                         0.200000   1.000      1.000   
04011500 4A   Endive                             4.000000   1.000      1.000   
95001510 O    Feijoa                             0.010000   1.000      1.000   FHE
04021520 4B   Fennel, Florence                   4.000000   1.000      1.000   
95001530 O    Fig                                0.010000   1.000      1.000   FHE
95001540 O    Fig, dried                         0.010000   1.000      1.000   FHE
14001550 14   Filbert                            0.010000   1.000      1.000   
14001560 14   Filbert, oil                       0.010000   1.000      1.000   
80001570 F    Fish-freshwater finfish            0.010000   1.000      1.000   FHE
80001580 F    Fish-freshwater finfish, farm ra   0.010000   1.000      1.000   FHE
80001590 F    Fish-saltwater finfish, tuna       0.010000   1.000      1.000   FHE
80001600 F    Fish-saltwater finfish, other      0.010000   1.000      1.000   FHE
80001610 F    Fish-shellfish, crustacean         0.010000   1.000      1.000   FHE
80001620 F    Fish-shellfish, mollusc            0.010000   1.000      1.000   FHE
20001630 20   Flaxseed, oil                      0.020000   1.000      1.000   Tol.
03001640 3    Garlic                             0.010000   1.000      1.000   FHE
03001650 3    Garlic, dried                      0.010000   1.000      1.000   FHE
03001651 3    Garlic, dried-babyfood             0.010000   1.000      1.000   FHE
01031660 1CD  Ginger                             0.010000   1.000      1.000   FHE
01031661 1CD  Ginger-babyfood                    0.010000   1.000      1.000   FHE
01031670 1CD  Ginger, dried                      0.010000   1.000      1.000   FHE
01011680 1AB  Ginseng, dried                     0.050000   1.000      1.000   
23001690 M    Goat, meat                         0.020000   1.000      1.000   
23001700 M    Goat, meat byproducts              0.040000   1.000      1.000   Rec. T
  Full comment: Rec. Tol.
23001710 M    Goat, fat                          0.005000   1.000      1.000   FHE
23001720 M    Goat, kidney                       0.040000   1.000      1.000   
23001730 M    Goat, liver                        0.040000   1.000      1.000   
13021740 13B  Gooseberry                         0.200000   1.000      1.000   
95001750 O    Grape                              0.060000   1.000      1.000   D28170
  Full comment: D281702
95001760 O    Grape, juice                       0.060000   1.100      1.000   
95001761 O    Grape, juice-babyfood              0.060000   1.100      1.000   
95001770 O    Grape, leaves                      0.200000   1.000      1.000   
95001780 O    Grape, raisin                      0.060000   2.300      1.000   D28170
  Full comment: D281702
95001790 O    Grape, wine and sherry             0.060000   1.000      1.000   
10001800 10   Grapefruit                         0.070000   1.000      1.000   
10001810 10   Grapefruit, juice                  0.070000   0.600      1.000   
06031820 6C   Guar, seed                         0.010000   1.000      1.000   
06031821 6C   Guar, seed-babyfood                0.010000   1.000      1.000   
95001830 O    Guava                              0.010000   1.000      1.000   FHE
95001831 O    Guava-babyfood                     0.010000   1.000      1.000   FHE
19011840 19A  Herbs, other                       0.010000   1.000      1.000   FHE
19011841 19A  Herbs, other-babyfood              0.010000   1.000      1.000   FHE
14001850 14   Hickory nut                        0.010000   1.000      1.000   
95001860 O    Honey                              0.010000   1.000      1.000   FHE
95001861 O    Honey-babyfood                     0.010000   1.000      1.000   FHE
09011870 9A   Honeydew melon                     0.200000   1.000      1.000   
95001880 O    Hop                                0.100000   1.000      1.000   
24001890 M    Horse, meat                        0.020000   1.000      1.000   
01011900 1AB  Horseradish                        0.050000   1.000      1.000   
13021910 13B  Huckleberry                        0.200000   1.000      1.000   
95001920 O    Jaboticaba                         0.010000   1.000      1.000   FHE
95001930 O    Jackfruit                          0.010000   1.000      1.000   FHE
05021940 5B   Kale                               0.820000   1.000      1.000   
95001950 O    Kiwifruit                          0.010000   1.000      1.000   FHE
05011960 5A   Kohlrabi                           0.980000   1.000      1.000   
10001970 10   Kumquat                            0.400000   1.000      1.000   
03001980 3    Leek                               0.010000   1.000      1.000   FHE
10001990 10   Lemon                              0.090000   1.000      1.000   
10002000 10   Lemon, juice                       0.090000   0.600      1.000   
10002001 10   Lemon, juice-babyfood              0.090000   0.600      1.000   
10002010 10   Lemon, peel                        0.090000   1.000      1.000   
19012020 19A  Lemongrass                         0.010000   1.000      1.000   FHE
06032030 6C   Lentil, seed                       0.010000   1.000      1.000   
04012040 4A   Lettuce, head                      4.000000   1.000      1.000   
04012050 4A   Lettuce, leaf                      4.000000   1.000      1.000   
10002060 10   Lime                               0.100000   1.000      1.000   
10002070 10   Lime, juice                        0.100000   0.600      1.000   
10002071 10   Lime, juice-babyfood               0.100000   0.600      1.000   
13012080 13A  Loganberry                         0.120000   1.000      1.000   
95002090 O    Longan                             0.010000   1.000      1.000   FHE
11002100 11   Loquat                             0.060000   1.000      1.000   
95002110 O    Lychee                             0.010000   1.000      1.000   FHE
95002120 O    Lychee, dried                      0.010000   1.000      1.000   FHE
14002130 14   Macadamia nut                      0.010000   1.000      1.000   
95002140 O    Mamey apple                        0.010000   1.000      1.000   FHE
95002150 O    Mango                              0.110000   1.000      1.000   D35744
  Full comment: D357449, avacado
95002151 O    Mango-babyfood                     0.110000   1.000      1.000   
95002160 O    Mango, dried                       0.110000   1.000      1.000   
95002170 O    Mango, juice                       0.110000   1.000      1.000   
95002171 O    Mango, juice-babyfood              0.110000   1.000      1.000   
95002180 O    Maple, sugar                       0.010000   1.000      1.000   FHE
95002190 O    Maple syrup                        0.010000   1.000      1.000   FHE
19012200 19A  Marjoram                           0.010000   1.000      1.000   FHE
19012201 19A  Marjoram-babyfood                  0.010000   1.000      1.000   FHE
28002210 M    Meat, game                         0.020000   1.000      1.000   
27002220 D    Milk, fat                          0.020000   1.000      1.000   
27002221 D    Milk, fat - baby food/infant for   0.020000   1.000      1.000   
27012230 D    Milk, nonfat solids                0.020000   1.000      1.000   
27012231 D    Milk, nonfat solids-baby food/in   0.020000   1.000      1.000   
27022240 D    Milk, water                        0.020000   1.000      1.000   
27022241 D    Milk, water-babyfood/infant form   0.020000   1.000      1.000   
27032251 D    Milk, sugar (lactose)-baby food/   0.020000   1.000      1.000   
15002260 15   Millet, grain                      0.020000   1.000      1.000   
95002270 O    Mulberry                           0.010000   1.000      1.000   FHE
95002280 O    Mushroom                           0.010000   1.000      1.000   FHE
05022290 5B   Mustard greens                     0.820000   1.000      1.000   
12002300 12   Nectarine                          0.210000   1.000      1.000   
15002310 15   Oat, bran                          0.020000   1.000      1.000   
15002320 15   Oat, flour                         0.020000   1.000      1.000   
15002321 15   Oat, flour-babyfood                0.020000   1.000      1.000   
15002330 15   Oat, groats/rolled oats            0.020000   1.000      1.000   
15002331 15   Oat, groats/rolled oats-babyfood   0.020000   1.000      1.000   
08002340 8    Okra                               0.080000   1.000      1.000   
95002350 O    Olive                              0.010000   1.000      1.000   FHE
95002360 O    Olive, oil                         0.010000   1.000      1.000   FHE
03002370 3    Onion, dry bulb                    0.030000   1.000      1.000   
03002371 3    Onion, dry bulb-babyfood           0.030000   1.000      1.000   
03002380 3    Onion, dry bulb, dried             0.030000   9.000      1.000   
03002381 3    Onion, dry bulb, dried-babyfood    0.030000   9.000      1.000   
03002390 3    Onion, green                       0.010000   1.000      1.000   FHE
10002400 10   Orange                             0.100000   1.000      1.000   
10002410 10   Orange, juice                      0.100000   0.600      1.000   
10002411 10   Orange, juice-babyfood             0.100000   0.600      1.000   
10002420 10   Orange, peel                       0.100000   1.000      1.000   
95002430 O    Palm heart, leaves                 0.010000   1.000      1.000   FHE
95002440 O    Palm, oil                          0.010000   1.000      1.000   FHE
95002441 O    Palm, oil-babyfood                 0.010000   1.000      1.000   FHE
95002450 O    Papaya                             0.110000   1.000      1.000   
95002451 O    Papaya-babyfood                    0.110000   1.000      1.000   
95002460 O    Papaya, dried                      0.110000   1.800      1.000   
95002470 O    Papaya, juice                      0.110000   1.500      1.000   
04012480 4A   Parsley, leaves                    4.000000   1.000      1.000   
19012490 19A  Parsley, dried leaves              0.010000   1.000      1.000   FHE
19012491 19A  Parsley, dried leaves-babyfood     0.010000   1.000      1.000   FHE
01012500 1AB  Parsley, turnip rooted             0.050000   1.000      1.000   
01012510 1AB  Parsnip                            0.050000   1.000      1.000   
01012511 1AB  Parsnip-babyfood                   0.050000   1.000      1.000   
95002520 O    Passionfruit                       0.010000   1.000      1.000   FHE
95002521 O    Passionfruit-babyfood              0.010000   1.000      1.000   FHE
95002530 O    Passionfruit, juice                0.010000   1.000      1.000   FHE
95002531 O    Passionfruit, juice-babyfood       0.010000   1.000      1.000   FHE
95002540 O    Pawpaw                             0.010000   1.000      1.000   FHE
06022550 6B   Pea, succulent                     0.010000   1.000      1.000   
06022551 6B   Pea, succulent-babyfood            0.010000   1.000      1.000   
06032560 6C   Pea, dry                           0.010000   1.000      1.000   
06032561 6C   Pea, dry-babyfood                  0.010000   1.000      1.000   
06012570 6A   Pea, edible podded, succulent      0.010000   1.000      1.000   
06032580 6C   Pea, pigeon, seed                  0.010000   1.000      1.000   
06022590 6B   Pea, pigeon, succulent             0.010000   1.000      1.000   
12002600 12   Peach                              0.070000   1.000      1.000   
12002601 12   Peach-babyfood                     0.070000   1.000      1.000   
12002610 12   Peach, dried                       0.070000   7.000      1.000   
12002611 12   Peach, dried-babyfood              0.070000   7.000      1.000   
12002620 12   Peach, juice                       0.070000   1.000      1.000   
12002621 12   Peach, juice-babyfood              0.070000   1.000      1.000   
95002630 O    Peanut                             0.050000   1.000      1.000   New To
  Full comment: New Tol.
95002640 O    Peanut, butter                     0.050000   1.000      1.000   
95002650 O    Peanut, oil                        0.050000   0.310      1.000   
11002660 11   Pear                               0.060000   1.000      1.000   
11002661 11   Pear-babyfood                      0.060000   1.000      1.000   
11002670 11   Pear, dried                        0.060000   6.250      1.000   
11002680 11   Pear, juice                        0.060000   0.750      1.000   
11002681 11   Pear, juice-babyfood               0.060000   0.750      1.000   
14002690 14   Pecan                              0.010000   1.000      1.000   
08002700 8    Pepper, bell                       0.080000   1.000      1.000   D28170
  Full comment: D281702, pepper 
08002701 8    Pepper, bell-babyfood              0.080000   1.000      1.000   
08002710 8    Pepper, bell, dried                0.080000   1.000      1.000   
08002711 8    Pepper, bell, dried-babyfood       0.080000   1.000      1.000   
08002720 8    Pepper, nonbell                    0.080000   1.000      1.000   
08002721 8    Pepper, nonbell-babyfood           0.080000   1.000      1.000   
08002730 8    Pepper, nonbell, dried             0.080000   1.000      1.000   
19022740 19B  Pepper, black and white            0.010000   1.000      1.000   FHE
19022741 19B  Pepper, black and white-babyfood   0.010000   1.000      1.000   FHE
95002750 O    Peppermint                         1.500000   1.000      1.000   
95002760 O    Peppermint, oil                    1.500000   0.050      1.000   
95002770 O    Persimmon                          0.010000   1.000      1.000   FHE
95002780 O    Pine nut                           0.010000   1.000      1.000   FHE
95002790 O    Pineapple                          0.010000   1.000      1.000   FHE
95002791 O    Pineapple-babyfood                 0.010000   1.000      1.000   FHE
95002800 O    Pineapple, dried                   0.010000   1.000      1.000   FHE
95002810 O    Pineapple, juice                   0.010000   1.000      1.000   FHE
95002811 O    Pineapple, juice-babyfood          0.010000   1.000      1.000   FHE
14002820 14   Pistachio                          0.010000   1.000      1.000   
95002830 O    Plantain                           0.010000   1.000      1.000   FHE
95002840 O    Plantain, dried                    0.010000   1.000      1.000   FHE
12002850 12   Plum                               0.071000   1.000      1.000   
12002851 12   Plum-babyfood                      0.071000   1.000      1.000   
12002860 12   Plum, prune, fresh                 0.071000   1.000      1.000   
12002861 12   Plum, prune, fresh-babyfood        0.071000   1.000      1.000   
12002870 12   Plum, prune, dried                 0.071000   5.000      1.000   
12002871 12   Plum, prune, dried-babyfood        0.071000   5.000      1.000   
12002880 12   Plum, prune, juice                 0.071000   1.400      1.000   
12002881 12   Plum, prune, juice-babyfood        0.071000   1.400      1.000   
95002890 O    Pomegranate                        0.010000   1.000      1.000   FHE
25002900 M    Pork, meat                         0.020000   1.000      1.000   
25002901 M    Pork, meat-babyfood                0.020000   1.000      1.000   
25002910 M    Pork, skin                         0.010000   1.000      1.000   FHE
25002920 M    Pork, meat byproducts              0.020000   1.000      1.000   
25002921 M    Pork, meat byproducts-babyfood     0.020000   1.000      1.000   
25002930 M    Pork, fat                          0.010000   1.000      1.000   FHE
25002931 M    Pork, fat-babyfood                 0.010000   1.000      1.000   FHE
25002940 M    Pork, kidney                       0.020000   1.000      1.000   
25002950 M    Pork, liver                        0.020000   1.000      1.000   
01032960 1C   Potato, chips                      0.250000   1.200      1.000   
01032970 1C   Potato, dry (granules/ flakes)     0.250000   1.700      1.000   
01032971 1C   Potato, dry (granules/ flakes)-b   0.250000   1.700      1.000   
01032980 1C   Potato, flour                      0.250000   1.700      1.000   
01032981 1C   Potato, flour-babyfood             0.250000   1.700      1.000   
01032990 1C   Potato, tuber, w/peel              0.250000   1.000      1.000   
01032991 1C   Potato, tuber, w/peel-babyfood     0.250000   1.000      1.000   
01033000 1C   Potato, tuber, w/o peel            0.250000   1.000      1.000   
01033001 1C   Potato, tuber, w/o peel-babyfood   0.250000   1.000      1.000   
60003010 P    Poultry, other, meat               0.010000   1.000      1.000   FHE
60003020 P    Poultry, other, liver              0.010000   1.000      1.000   FHE
60003030 P    Poultry, other, meat byproducts    0.010000   1.000      1.000   FHE
60003040 P    Poultry, other, fat                0.010000   1.000      1.000   FHE
60003050 P    Poultry, other, skin               0.010000   1.000      1.000   FHE
95003060 O    Psyllium, seed                     0.010000   1.000      1.000   FHE
10003070 10   Pummelo                            0.100000   1.000      1.000   
09023080 9B   Pumpkin                            0.200000   1.000      1.000   
09023090 9B   Pumpkin, seed                      0.200000   1.000      1.000   
11003100 11   Quince                             0.060000   1.000      1.000   
95003110 O    Quinoa, grain                      0.010000   1.000      1.000   FHE
29003120 M    Rabbit, meat                       0.020000   1.000      1.000   
04013130 4A   Radicchio                          4.000000   1.000      1.000   
01013140 1AB  Radish, roots                      0.050000   1.000      1.000   
02003150 2    Radish, tops                       0.010000   1.000      1.000   FHE
01013160 1AB  Radish, Oriental, roots            0.050000   1.000      1.000   
02003170 2    Radish, Oriental, tops             0.010000   1.000      1.000   FHE
05023180 5B   Rape greens                        0.820000   1.000      1.000   
20003190 20   Rapeseed, oil                      0.020000   1.000      1.000   
20003191 20   Rapeseed, oil-babyfood             0.020000   1.000      1.000   
13013200 13A  Raspberry                          0.120000   1.000      1.000   
13013201 13A  Raspberry-babyfood                 0.120000   1.000      1.000   
13013210 13A  Raspberry, juice                   0.120000   1.000      1.000   
13013211 13A  Raspberry, juice-babyfood          0.120000   1.000      1.000   
04023220 4B   Rhubarb                            4.000000   1.000      1.000   
15003230 15   Rice, white                        0.010000   1.000      1.000   
15003231 15   Rice, white-babyfood               0.010000   1.000      1.000   
15003240 15   Rice, brown                        0.010000   1.000      1.000   
15003241 15   Rice, brown-babyfood               0.010000   1.000      1.000   
15003250 15   Rice, flour                        0.010000   1.000      1.000   
15003251 15   Rice, flour-babyfood               0.010000   1.000      1.000   
15003260 15   Rice, bran                         0.010000   0.900      1.000   
15003261 15   Rice, bran-babyfood                0.010000   0.900      1.000   
01013270 1AB  Rutabaga                           0.050000   1.000      1.000   
15003280 15   Rye, grain                         0.020000   1.000      1.000   
15003290 15   Rye, flour                         0.020000   1.000      1.000   
20003300 20   Safflower, oil                     0.020000   1.000      1.000   
20003301 20   Safflower, oil-babyfood            0.020000   1.000      1.000   
01013310 1AB  Salsify, roots                     0.050000   1.000      1.000   
02003320 2    Salsify, tops                      0.010000   1.000      1.000   FHE
95003330 O    Sapote, Mamey                      0.400000   1.000      1.000   
19013340 19A  Savory                             0.010000   1.000      1.000   FHE
95003350 O    Seaweed                            0.010000   1.000      1.000   FHE
95003351 O    Seaweed-babyfood                   0.010000   1.000      1.000   FHE
95003360 O    Sesame, seed                       0.010000   1.000      1.000   FHE
95003361 O    Sesame, seed-babyfood              0.010000   1.000      1.000   FHE
95003370 O    Sesame, oil                        0.010000   1.000      1.000   FHE
95003371 O    Sesame, oil-babyfood               0.010000   1.000      1.000   FHE
03003380 3    Shallot                            0.010000   1.000      1.000   FHE
26003390 M    Sheep, meat                        0.020000   1.000      1.000   
26003391 M    Sheep, meat-babyfood               0.020000   1.000      1.000   
26003400 M    Sheep, meat byproducts             0.040000   1.000      1.000   
26003410 M    Sheep, fat                         0.010000   1.000      1.000   FHE
26003411 M    Sheep, fat-babyfood                0.010000   1.000      1.000   FHE
26003420 M    Sheep, kidney                      0.040000   1.000      1.000   
26003430 M    Sheep, liver                       0.040000   1.000      1.000   
15003440 15   Sorghum, grain                     0.020000   1.000      1.000   
15003450 15   Sorghum, syrup                     0.020000   1.000      1.000   
95003460 O    Soursop                            0.010000   1.000      1.000   FHE
06003470 6    Soybean, seed                      0.010000   1.000      1.000   D28170
  Full comment: D281702
06003480 6    Soybean, flour                     0.010000   1.000      1.000   
06003481 6    Soybean, flour-babyfood            0.010000   1.000      1.000   
06003490 6    Soybean, soy milk                  0.010000   1.000      1.000   
06003491 6    Soybean, soy milk-babyfood or in   0.010000   1.000      1.000   
06003500 6    Soybean, oil                       0.010000   1.000      1.000   
06003501 6    Soybean, oil-babyfood              0.010000   1.000      1.000   
95003510 O    Spanish lime                       0.010000   1.000      1.000   FHE
95003520 O    Spearmint                          1.500000   1.000      1.000   
95003530 O    Spearmint, oil                     1.500000   0.050      1.000   D28170
  Full comment: D281702
19023540 19B  Spices, other                      0.010000   1.000      1.000   FHE
19023541 19B  Spices, other-babyfood             0.010000   1.000      1.000   FHE
04013550 4A   Spinach                            4.000000   1.000      1.000   
04013551 4A   Spinach-babyfood                   4.000000   1.000      1.000   
09023560 9B   Squash, summer                     0.200000   1.000      1.000   
09023561 9B   Squash, summer-babyfood            0.200000   1.000      1.000   
09023570 9B   Squash, winter                     0.200000   1.000      1.000   
09023571 9B   Squash, winter-babyfood            0.200000   1.000      1.000   
95003580 O    Starfruit                          0.010000   1.000      1.000   FHE
95003590 O    Strawberry                         0.300000   1.000      1.000   
95003591 O    Strawberry-babyfood                0.300000   1.000      1.000   
95003600 O    Strawberry, juice                  0.300000   1.000      1.000   
95003601 O    Strawberry, juice-babyfood         0.300000   1.000      1.000   
95003610 O    Sugar apple                        0.010000   1.000      1.000   FHE
95003620 O    Sugarcane, sugar                   0.010000   1.000      1.000   FHE
95003621 O    Sugarcane, sugar-babyfood          0.010000   1.000      1.000   FHE
95003630 O    Sugarcane, molasses                0.010000   1.000      1.000   FHE
95003631 O    Sugarcane, molasses-babyfood       0.010000   1.000      1.000   FHE
20003640 20   Sunflower, seed                    0.020000   1.000      1.000   
20003650 20   Sunflower, oil                     0.020000   1.000      1.000   
20003651 20   Sunflower, oil-babyfood            0.020000   1.000      1.000   
01033660 1CD  Sweet potato                       0.020000   1.000      1.000   
01033661 1CD  Sweet potato-babyfood              0.020000   1.000      1.000   
04023670 4B   Swiss chard                        4.000000   1.000      1.000   
95003680 O    Tamarind                           0.010000   1.000      1.000   FHE
10003690 10   Tangerine                          0.100000   1.000      1.000   
10003700 10   Tangerine, juice                   0.100000   0.600      1.000   
01033710 1CD  Tanier, corm                       0.020000   1.000      1.000   
95003720 O    Tea, dried                         0.010000   1.000      1.000   FHE
95003730 O    Tea, instant                       0.010000   1.000      1.000   FHE
08003740 8    Tomatillo                          0.080000   1.000      1.000   
08003750 8    Tomato                             0.080000   1.000      1.000   
08003751 8    Tomato-babyfood                    0.080000   1.000      1.000   
08003760 8    Tomato, paste                      0.080000   3.800      1.000   D26507
  Full comment: D265079
08003761 8    Tomato, paste-babyfood             0.080000   3.800      1.000   
08003770 8    Tomato, puree                      0.080000   1.700      1.000   D26507
  Full comment: D265079
08003771 8    Tomato, puree-babyfood             0.080000   1.700      1.000   
08003780 8    Tomato, dried                      0.080000  14.300      1.000   
08003781 8    Tomato, dried-babyfood             0.080000  14.300      1.000   
08003790 8    Tomato, juice                      0.080000   1.500      1.000   
95003800 O    Tomato, Tree                       0.010000   1.000      1.000   FHE
15003810 15   Triticale, flour                   0.020000   1.000      1.000   
15003811 15   Triticale, flour-babyfood          0.020000   1.000      1.000   
50003820 P    Turkey, meat                       0.010000   1.000      1.000   FHE
50003821 P    Turkey, meat-babyfood              0.010000   1.000      1.000   FHE
50003830 P    Turkey, liver                      0.010000   1.000      1.000   FHE
50003831 P    Turkey, liver-babyfood             0.010000   1.000      1.000   FHE
50003840 P    Turkey, meat byproducts            0.010000   1.000      1.000   FHE
50003841 P    Turkey, meat byproducts-babyfood   0.010000   1.000      1.000   FHE
50003850 P    Turkey, fat                        0.010000   1.000      1.000   FHE
50003851 P    Turkey, fat-babyfood               0.010000   1.000      1.000   FHE
50003860 P    Turkey, skin                       0.010000   1.000      1.000   FHE
50003861 P    Turkey, skin-babyfood              0.010000   1.000      1.000   FHE
01033870 1CD  Turmeric                           0.250000   1.000      1.000   
01013880 1AB  Turnip, roots                      0.050000   1.000      1.000   
05023890 5B   Turnip, greens                     0.820000   1.000      1.000   
95003900 O    Vinegar                            0.010000   1.000      1.000   FHE
14003910 14   Walnut                             0.010000   1.000      1.000   
86010000 O    Water, direct, all sources         0.011310   1.000      1.000   
86020000 O    Water, indirect, all sources       0.011310   1.000      1.000   
09013990 9A   Watermelon                         0.200000   1.000      1.000   
09014000 9A   Watermelon, juice                  0.200000   1.000      1.000   
15004010 15   Wheat, grain                       0.020000   1.000      1.000   
15004011 15   Wheat, grain-babyfood              0.020000   1.000      1.000   
15004020 15   Wheat, flour                       0.020000   1.000      1.000   
15004021 15   Wheat, flour-babyfood              0.020000   1.000      1.000   
15004030 15   Wheat, germ                        0.020000   1.000      1.000   
15004040 15   Wheat, bran                        0.020000   1.000      1.000   
15004050 15   Wild rice                          0.020000   1.000      1.000   
01034060 1CD  Yam, true                          0.250000   1.000      1.000   
01034070 1CD  Yam bean                           0.250000   1.000      1.000   
Attachment 3.  Summary of the acute dietary exposure analysis for thiamethoxam.


U.S. Environmental Protection Agency                                  Ver. 2.02
DEEM-FCID ACUTE Analysis for THIAMETHOXAM                        (1994-98 data)
Residue file: 060109 2010 Acute T+Water.R98       Adjustment factor #2 NOT used.
Analysis Date: 09-28-2010/14:24:08    Residue file dated: 09-28-2010/14:19:26/8
Daily totals for food and foodform consumption used.
Run Comment: "Acute and Chronic RfDs = aPAD and cPAD"
===============================================================================

Summary calculations (per capita):

                    95th Percentile      99th Percentile      99.9th Percentile
                   Exposure   % aRfD    Exposure   % aRfD    Exposure   % aRfD 
                  ---------- --------  ---------- --------  ---------- --------
U.S. Population:
                    0.018094     5.17    0.029790     8.51    0.058415    16.69 
All infants:
                    0.033165     9.48    0.053499    15.29    0.087409    24.97 
Children 1-2 yrs:
                    0.032947     9.41    0.056186    16.05    0.108420    30.98 
Children 3-5 yrs:
                    0.026627     7.61    0.046231    13.21    0.079162    22.62 
Children 6-12 yrs:
                    0.018819     5.38    0.034746     9.93    0.071004    20.29 
Youth 13-19 yrs:
                    0.014311     4.09    0.022203     6.34    0.038760    11.07 
Adults 20-49 yrs:
                    0.016277     4.65    0.025243     7.21    0.042160    12.05 
Adults 50+ yrs:
                    0.016617     4.75    0.025593     7.31    0.040500    11.57 
Females 13-49 yrs:
                    0.016123     4.61    0.025604     7.32    0.046388    13.25 Attachment 4.  Summary of the chronic dietary exposure analysis for thiamethoxam.

U.S. Environmental Protection Agency                                 Ver. 2.00
DEEM-FCID Chronic analysis for THIAMETHOXAM                     (1994-98 data)
Residue file name: C:\Documents and Settings\dmcneill\My Documents\Thiamethoxam_3\060109 2010 T+FHE+Water.R98
                                                 Adjustment factor #2 NOT used.
Analysis Date 09-28-2010/14:21:15     Residue file dated: 09-28-2010/14:20:28/8
Reference dose (RfD, Chronic) = .012 mg/kg bw/day
===============================================================================
                    Total exposure by population subgroup
-------------------------------------------------------------------------------
                                                    Total Exposure
                                         -----------------------------------
          Population                         mg/kg             Percent of   
           Subgroup                       body wt/day             Rfd       
--------------------------------------   -------------       ---------------
U.S. Population (total)                     0.002825                23.5%

U.S. Population (spring season)             0.002894                24.1%
U.S. Population (summer season)             0.002814                23.5%
U.S. Population (autumn season)             0.002786                23.2%
U.S. Population (winter season)             0.002809                23.4%

Northeast region                            0.002932                24.4%
Midwest region                              0.002844                23.7%
Southern region                             0.002543                21.2%
Western region                              0.003155                26.3%

Hispanics                                   0.002912                24.3%
Non-hispanic whites                         0.002826                23.5%
Non-hispanic blacks                         0.002448                20.4%
Non-hisp/non-white/non-black                0.003674                30.6%

All infants (< 1 year)                      0.003052                25.4%
Nursing infants                             0.001338                11.2%
Non-nursing infants                         0.003703                30.9%
Children 1-6  yrs                           0.004617                38.5%
Children 7-12 yrs                           0.003133                26.1%

Females 13-19 (not preg or nursing)         0.002248                18.7%
Females 20+ (not preg or nursing)           0.002722                22.7%
Females 13-50 yrs                           0.002669                22.2%
Females 13+ (preg/not nursing)              0.002473                20.6%
Females 13+ (nursing)                       0.003126                26.1%

Males 13-19 yrs                             0.002398                20.0%
Males 20+ yrs                               0.002493                20.8%
Seniors 55+                                 0.002624                21.9%

Children 1-2 yrs                            0.005150                42.9%
Children 3-5 yrs                            0.004520                37.7%
Children 6-12 yrs                           0.003241                27.0%
Youth 13-19 yrs                             0.002333                19.4%
Adults 20-49 yrs                            0.002591                21.6%
Adults 50+ yrs                              0.002648                22.1%
Females 13-49 yrs                           0.002617                21.8%
-------------------------------------------------------------------------------
