	

	UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

	WASHINGTON, D.C.  20460

                                                    OFFICE OF
PREVENTION, PESTICIDES AND TOXIC SUBSTANCES

	

  SEQ CHAPTER \h \r 1 MEMORANDUM

Date: February 23, 2010

SUBJECT:	Updated Review of the Allethrin (bioallethrin and esbiothrin)
Incidents Reports  

 

PC Code:  004003,004007	DP Barcode:  D373201

Decision No.:  N/A	Registration No.: N/A

Petition No.: N/A	Regulatory Action: N/A

Risk Assessment Type: N/A	Case No.: N/A

TXR No.: N/A	CAS No.: 584-79-2

MRID No.: N/A	40 CFR: N/A

		              									Ver.Apr.08

	          	

FROM:          Jessie Cordova, Information Technology Specialist

	           Science Information MGMT. Branch (SIMB)

	           Health Effect Division (7509P)	  SEQ CHAPTER \h \r 1 

		

THROUGH:	Mary Manibusan, Branch Chief

		Toxicology and Epidemiology Branch 

		Health Effects Division (7509P)	

		

TO:	           Molly Clayton, CRM

                       Special Review and Reregistration Division
(7508P)

BACKGROUND		

The OPP Incident Data System (IDS) was consulted for poisoning incident
data on the active ingredient Allethrin (bioallethrin and esbiothrin).
The purpose of the database search is to identify potential patterns on
the extent and severity of the health effects attributed to Allethrin
(bioallethrin and esbiothrin) exposure.  The IDS includes reports of
incidents from various sources, including mandatory Federal Insecticide,
Fungicide and Rodenticide Act (FIFRA) Section 6(a)(2) reports from
registrants, other federal and state health and environmental agencies
and individual consumers.  

The following databases were not searched for poisoning incident data: 
the American Association of Poison Control Centers National Poison Data
System (NPDS), the California Pesticide Illness Surveillance Program,
and the National Institute of Occupational Safety and Health’s
Sentinel Event Notification System for Occupational Risks (NIOSH
SENSOR).  The EPA is supplying the following incident report to fulfill
our requirement to docket summaries of incident data that were reported
to the Agency.  This report represents 6 incidents occurring in the
United States from 2002 to the present for the single chemical only.  

Reports of adverse health effects allegedly due to a specific pesticide
exposure (an “incident”) are largely self-reported and therefore,
generally speaking, neither exposure to a pesticide or reported symptom
(or the connection between the two) is validated.  However, incident
information can be an important feedback loop to the Agency –
incidents of severe outcome, or a suggested pattern or trend among less
severe incidents can signal the Agency to further investigate a
particular chemical or product.

The FIFRA Section 6(a)(2) includes reports of alleged human health
incidents from various sources, including mandatory reports from
registrants, other federal and state health and environmental agencies
and individual consumers.  Since 1992, OPP compiles these reports in an
Incident Data System (IDS).  Reports submitted to the IDS represent
anecdotal reports or allegations only, unless otherwise stated in this
report.  Typically, OPP does not draw firm conclusions implicating the
pesticide is causally associated with the reported health effects. 
Nevertheless, in some instances if enough cases and/or documentation of
exposure and health effect or suggested patterns of exposure and
response are indicative of a strong relationship, risk mitigation
measures may be suggested.

The evaluation of incident data for Allethrin (bioallethrin-004003)
identified  six incidents (see table at the end of document for
details), and for Allethrin (esbiothrin-004007) identified no incidents.
For the bioallethrin incidents identified, symptoms appear generic and
not confirmed to be related to exposure; there is no clear pattern of
toxicity or consistency of exposure scenarios. 

IDS Report	 	 	 	 	 	 

Chemical: Allethrin (Bioallethrin)	004003	Human Incidents	 	 

 	 	 	 	 	 	 	 	 

Incident Number	Incident Date	Product Name	Registration Number	City
State	Exposure Type*	Incident Description

013098	028	15-Jun-02	OFF! MOSQUITO COIL III	00482200501	RIVER RIDGE	LA
HC	A 49 year old Male caller states that her brother was sleeping on the
porch all night with the product burning and Sunday morning around 4 am
he woke up with Chest Pain. A couple of hours later he started to Pass
Out. He was brought into the hospital and they did other kinds of tests.

013226	042	16-Jul-02	OFF! MOSQUITO COIL III REFILL	00482200501	LITHONIA
GA	HC	A 29 year old Male the product was actually lit on a table near
the patient’s work desk. Apparently this was inside of a large
building that had large opens doors on either end of the building. The
business is a sign making shop. The patient had recently complained of
the odor from the product and even attempted to move it farther away
from his desk. Caller is concerned about her employee who in the last 30
mins went into Respiratory Arrest and had some sort of neurological
effect that caused his limbs to draw up. Pt is currently at HCF and MDs
for more evaluation.

013608	001	21-Oct-02	THERMACELL MOSQUITO REPELLENT	04391700007 071910
ORMOND BEACH	FL	HC	Unknown Adult (18-64 years old) Female, Woman’s
husband and son used the product in their hunting tree stand. She washed
their hunting clothes twice and had an allergic reaction, By the end of
the week she was feeling better when on Saturday her son, wearing his
hunting clothes, entered the room she was in and she had another
allergic reaction. She reported Itching, Hives, Tightening in Chest, and
Difficulty Breathing.

014420	071	30-Aug-03	OFF! MOSQUITO COIL III	00482200501	HONOLULU	HI	HC	A
30 year old Male, product was burned outdoors last night at a friend’s
home. Caller thinks he inhaled some as the wind blew some in his face.
He developed a Headache last night which continues today. He feels dizzy
today.

014507	007	03-Sep-03	OFF! MOSQUITO COIL III	00482200501	OXFORD	MI	HC	A
28 year old Male, caller's boyfriend passed out after lighting the
product happened 12 hrs ago. Smoke was wafting into his face. Sat next
to it for 15 minutes, stood up and fainted. Went inside, washed his
face, felt air within 15 minutes of incident. Recommend seek medical
evaluation.

020097	024	16-Aug-08	OFF! MOSQUITO COIL III	00482200501	CAMDENTON	MO	HC
A 60 year old Female, caller states that her mother was visiting at a
neighbor's home 12 hours ago. The neighbors were burning the product
throughout the night. Caller states that her mother goes into congestive
heart failure when she smells or ingests cinnamon. Her mother is
currently on her way to the hospital. She developed Wheezing, and
Shortness of Breath that has gradually worsened.



* Severity Categories

H	Human

H-A	Human Fatality

H-B	Human Major

H-C	Human Moderate

H-D	Human Minor

H-E	Human Unspecified



                                                                        
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