    SEQ CHAPTER \h \r 1 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C.  20460

Office of Chemical Safety

 and Pollution Prevention

MEMORANDUM

DATE:  	May 3, 2010

SUBJECT:	Thiamethoxam.  Acute and Chronic Aggregate Dietary (Food and
Drinking Water) Exposure and Risk Assessments for the Section 3
Registration as a Seed Treatment on Onion, Dry Bulb, Removing the
Geographical Limitations on the Foliar Treatment of Barley.  

PC Code:  060109	DP Barcodes:  D373595/D375247

Decision Number:   415289	Registration Number:  100-1294                
             

Petition Number: 9F7582	Regulatory Action:  Section 3

                                 Registration

Assessment Type:  Dietary	Case Number:  None

TXR Number:  None	CAS Number:  153719-23-4

MRID Number:  None	40CFR §180.565



REVIEWER:	Dennis McNeilly, Chemist

		Risk Assessment Branch II (RAB2)

Health Effects Division (HED), 7509P

THROUGH:	Amelia M. Acierto, Chemist

		Mohsen Sahafeyan, Chemist

Dietary Exposure Science Advisory Council (DESAC)

Health Effects Division (HED), 7509P

TO:	Dennis McNeilly, Chemist

Risk Assessment Branch II (RAB2)/HED, 7509P

               &

		Julie Chao/Venus Eagle, Team 01

		Insecticide/Rodenticide Branch

		Registration Division (RD), 7505P

Executive Summary

n Model software with the Food Commodity Intake Database (DEEM-FCID™),
Version 2.03, which uses food consumption data from the US Department of
Agriculture’s Continuing Surveys of Food Intakes by Individuals
(CSFII), collected from 1994 to 1996, and 1998.  These analyses were
performed to support the Section 3 request for thiamethoxam use as a
seed treatment for onion, dry bulb.  These analyses also support
removing the current geographical use limitation for the foliar
treatment of barley; as these assessments assume 100% crop treated for
barley.

Tolerances for residues of thiamethoxam are listed in 40 CFR §180.565
and are expressed in terms of the combined residues of the insecticide
thiamethoxam and its metabolite CGA-322704.  Thiamethoxam’s major
metabolite is CGA-322704, which is also the registered active ingredient
clothianidin.  Clothianidin has a complete toxicological database and
appears to have effects in mammals that are different from those of
thiamethoxam.  Nevertheless, in conducting these assessments, residues
of clothianidin coming from thiamethoxam use were added to residues of
thiamethoxam.  The total or combined residue was then used to estimate
acute and chronic dietary exposure and risk.  Both the acute and chronic
assessments assumed that 100% of crops were treated with registered or
requested uses of thiamethoxam.  This assumption is highly conservative
with respect to thiamethoxam use and obviates the need to include
residues of clothianidin coming from clothianidin uses.  A new
chlothianidin dietary assessment and risk assessment accounting for
clothianidin residues on onion, dry bulb resulting from thiamethoxam
application is not necessary, chlothianidin is already registered for
use on Vegetable, bulb group 3-07, which includes onion, dry bulb (0.45
ppm tolerance).

The acute assessment is based on tolerance level residues of
thiamethoxam/clothianidin (the tolerance is for combined residues).  The
chronic analysis is based on tolerance level and/or average field trial
(see D364256, D. McNeilly, June 30, 2009) residues and all assume 100%
crop treated.  The assumption of 100% CT in these analyses (acute and
chronic) results in a conservative assessment for thiamethoxam. 
Clothianidin and thiamethoxam are not expected to be used on the same
crop, as a recommendation against this appears on the end-use labels. 
The analyses included direct incorporation of estimated
thiamethoxam/clothianidin residues in drinking water.  For water, the
highest estimate from conservative models was used for both the acute
and the chronic dietary exposure analyses.

Based on these highly conservative assumptions, acute dietary risk
estimates at the 95th percentile of exposure are less than or equal to
9.5% of the acute population-adjusted dose (aPAD) for all population
subgroups.  Chronic dietary risk estimates are less than or equal to 42%
of the chronic population-adjusted dose (cPAD) for all population
subgroups.  Generally, HED is concerned when risk estimates exceed 100%
of the PAD; therefore, all acute and chronic dietary risk estimates are
below HED’s level of concern (LOC).

These analyses indicate that there are no dietary exposure
considerations that would preclude registration of thiamethoxam for the
requested use on dry bulb onions.

1.	Introduction

Dietary risk assessment incorporates both exposure and toxicity of a
given pesticide.  For acute and chronic assessments, the risk is
expressed as a percentage of a maximum acceptable dose (the dose which
HED has concluded will result in no unreasonable adverse health
effects).  This dose is referred to as the population adjusted dose
(PAD).  The PAD is equivalent to the point of departure (POD), such as
the NOAEL or LOAEL, divided by the requisite uncertainty and/or safety
factors.  

For acute and non-cancer chronic exposures, HED is concerned when
estimated dietary risk exceeds 100% of the PAD.  References which
discuss the acute and chronic risk assessments in more detail are
available on the EPA pesticides web site, Available Information on
Assessing Exposure from Pesticides, A User’s Guide (21 June 2000),
which can be accessed via the web link
http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf (or see
SOP 99.6, dated 8/20/1999).  

The most recent dietary risk assessment for thiamethoxam was conducted
by D. McNeilly (D364256, 30 June 2009).  Table 3 in that review,
provides the anticipated residues used in the chronic assessment.

Thiamethoxam is a member of the neonicotinoid class of pesticides and
its major metabolite clothianidin is another neonicotinoid.  Structural
similarities or common effects do not constitute a common mechanism of
toxicity.  Although clothianidin and thiamethoxam bind selectively to
insect nicotinic acetylcholine receptors (nAChR), the specific binding
site(s)/receptor(s) for clothianidin, thiamethoxam, and the other
neonicotinoids are unknown at this time.  Additionally, the commonality
of the binding activity itself is uncertain, as preliminary evidence
suggests that clothianidin operates by direct competitive inhibition,
while thiamethoxam is a non-competitive inhibitor.  Furthermore, even if
future research shows that neonicotinoids share a common binding
activity to a specific site on insect nicotinic acetylcholine receptors,
there is not necessarily a relationship between this pesticidal action
and a mechanism of toxicity in mammals.  Structural variations between
the insect and mammalian nAChRs produce quantitative differences in the
binding affinity of the neonicotinoids towards these receptors, which,
in turn, confers the notably greater selective toxicity of this class
towards insects, including aphids and leafhoppers, compared to mammals. 
While the insecticidal action of the neonicotinoids is neurotoxic, the
most sensitive regulatory endpoint for clothianidin is based on
unrelated effects in mammals, including changes in body and thymus
weights, delays in sexual maturation, and still births.  Additionally,
the most sensitive toxicological effect in mammals differs across the
neonicotinoids (e.g., testicular tubular atrophy with thiamethoxam;
mineralized particles in thyroid colloid with imidaclopid).  Thus, there
is currently no evidence to indicate that neonicotinoids share common
mechanisms of toxicity, and EPA is not following a cumulative risk
approach based on a common mechanism of toxicity for the neonicotinoids.

2.	Residue Information

Tolerances have been established for both thiamethoxam (40CFR §180.565)
and clothianidin (40CFR §180.586) on a variety of commodities.  This
assessment includes residue estimates associated with the requested
Section 3 registration of thiamethoxam on onions, dry bulb (see Table
1).  The residue of concern for this dietary risk assessment is
thiamethoxan and its metabolite, clothianidin.



Table 1.    Tolerance Summary for Thiamethoxam Proposed Uses on Onions,
dry bulb.



Commodity	Proposed Tolerance (ppm)	Recommended Tolerance (ppm)	Comments;
Correct Commodity Definition

Tolerances Proposed under 180.565(a)

Onion, dry bulb	0.03	0.03	Onion, dry bulb



The estimates of residues in livestock commodities are as recommended in
the recent thiamethoxam risk assessment (D348703, M. Doherty, 25 Sept
2008).

Empirical processing factors were used when available.  For food forms
without empirical processing factors, DEEM 7.81 default values were
used.  A complete listing of the processing factors used can be found in
Table 3 of HED’s June 30, 2009 review for thiamethoxam (D364256,
Dennis McNeilly).  A complete listing of the residues and processing
factors used in the analyses are included in Attachments 1, and 2. 

The chronic assessment makes use of average residue values from the
thiamethoxam field trials for the selected commodities which are listed
in HED’s last dietary analyses for thiomethoxam (D364256, D. McNeilly,
30 June 2009).   Although monitoring data are available for some
commodities, field trial residues were used for all the uses, along with
a high end estimate of drinking water residues.  Therefore this
assessment is considered conservative.

3.	Drinking Water Data

The drinking water residues used in these dietary risk assessments were
provided by EFED (D368072, C. Kopert, 2 February 2010), and incorporated
directly into the dietary assessments.  Water residues were incorporated
in DEEM-FCID via entry into the food categories “water, direct, all
sources” and “water, indirect, all sources.”  The estimated
drinking water concentrations (EDWCs) in surface water are 0.13177 ppm
and 0.01131 ppm for acute and chronic scenarios, respectively. 
Typically, HED uses the higher of the surface or groundwater estimates
for each duration when assessing dietary risk, with the surface water
having higher values in this case.  

The EDWCs were incorporated into the acute and chronic thiamethoxam
assessments.  Clothianidin, a major metabolite of thiamethoxam in plants
and livestock, is not a significant degradate of thiamethoxam in surface
or groundwater sources of drinking water. 

A Tier II screening-level drinking water assessment was conducted for
the proposed seed treatment of dry bulb onions.  EFED also evaluated
carrots, leafy vegetables and Brassica (cole) leafy vegetables because
previous assessments on these commodities were conducted at a lower
application rate.  

For surface water, the EDWCs for the crops modeled in this assessment
did not exceed the previous EDWCs for rice reported in the previous
drinking water assessment (D363202, F. Khan, 07 April 2009). The
reported acute concentration of 131.77 µg/L, annual mean (chronic)
concentration of 11.31 µg/L and the highest 30 year annual average
concentration of 11.31 µg/L from the rice model are higher than the
reported EDWCs for various uses in Table 2.  Therefore, the current
EDWCs for surface water do not supersede the drinking water
concentrations previously estimated for this chemical (D363202).

For groundwater, based on the proposed highest annual use rate for leafy
vegetables, the SCI-GROW model concentration of thiamethoxam was 3.42
µg/L.  This value was compared to 7.94 µg/L reported for grapes in an
earlier drinking water assessment (D329467) dated 10 January 2007. 
However, further review of this assessment revealed that the aerobic
soil metabolism half-life input value was incorrect causing an incorrect
groundwater EDWC value.  The 90th upper percentile on the mean was used
instead of the mean half-life value.  Given that there were less than
four half-life values in the data set, the value was re-calculated based
on the mean half-life value, as specified in the SCI-GROW input guidance
embedded within the model.  The correct EDWC is 4.14 µg/L.  Since 3.42
µg/L is less than 4.14 µg/L, the current EDWC does not supersede the
recalculated estimated drinking water concentration for groundwater.

The acute scenario EDWC in surface water (0.13177 ppm) was obtained via
exposure modeling which utilized the FIRST (FQPA Index Reservoir
Screening Tool) model.  This model and its description are available at
the EPA internet website via the web link,   HYPERLINK
"http://www.epa.gov/oppefed1/models/water/" 
http://www.epa.gov/oppefed1/models/water/ .  

Table 2. Tier II Estimated Drinking Water Concentrations (EDWCs)
resulting from applications of Thiamethoxam.

Drinking Water Source (model)	Use

Scenario 

(modeled rate)	1-in-10 year acute (µg/L)	1-in-10 year chronic (µg/L)
30- year average (µg/L)

Surface Water (PRZM/EXAMS)	Dry Bulb Onions:

CA Onion

GA Onion

(1 app. X 0.18 lbs ai/acre)	

0.94

12.25

	

0.15

0.92	

0.03

0.26

	Carrots:

FL Carrots 

(1 app. X 0.22 lbs ai/acre)	

9.25	

0.53	

0.36

	Brassica (Cole) Leafy Vegs:

CA Cole Crop

(1 app. X 0.22 lbs ai/acre)	

7.90	

1.06	

0.44

	Leafy Vegetables:

CA Lettuce (1 run)

(2 app. X 0.133 lbs. ai/acre)

CA Lettuce (2 runs)

(1 app. X 0.133 lbs. ai/acre)

(1 app. X 0.133 lbs. ai/acre)	

12.19

11.85

5.86	

2.07

1.84

0.71	

1.03

0.64

0.39

Tail water 

	Rice

(0.173 lbs ai/A/year)	131.771,2	11.311,3	11.311,3

	Cranberry

(0.188 lbs ai/A/year)	54.752	4.503	4.503

Groundwater 

(SCI-GROW)	Leafy Vegetables:

(0.22 lbs a.i./acre)

	

3.42	

3.42	

3.42

	Grape

(0.266 lb ai/A)	4.14	4.14	4.14

Bold text denotes maximum estimated EDWC values.  All values adjusted
with PCA factor of 0.87.

1 = Recommended EDWCs for surface water 

2 = EDWCs based on day 1 

3 = EDWCs based on average of 365days

Monitoring Data

Two small-scale prospective groundwater (PGW) monitoring studies were
initiated in southwest Michigan in June 2001 and southwestern Georgia in
the spring of 2002, to determine the potential for the active ingredient
thiamethoxam and its degradates to reach groundwater when used in a
vulnerable hydrogeologic setting. Analytical data were collected for 47
months (from  treatment in the spring of 2001 until May 2005) in the
Michigan study and for 36 months (from treatment in the spring of 2002
until May 2005) in the Georgia study.  The monitoring data demonstrate
that concentrations of the analytes of interest have peaked in the
groundwater and have either completely dissipated or have leveled off
for an extended period of time.

In Michigan, thiamethoxam residues found in soil-pore water samples have
clearly peaked and then declined. No quantifiable residues of
thiamethoxam > LOQ (0.05 ppb) were observed in any of the 3, 6, and 9-ft
lysimeters after the 36, 16, and 41-MAT sampling events, respectively.
By the 47-MAT sampling event only trace level detections of thiamethoxam
were observed in three of the 15-ft. lysimeter units (maximum
concentration 0.11 ppb).

In Georgia, thiamethoxam residues have only been confirmed in four
shallow monitoring wells (MW-1S, MW-3S, MW-5S, and MW-8S) during 47
months of sampling. Thiamethoxam residues in groundwater peaked at
43-MAT, and by 47-MAT residues were confined to two shallow monitoring
wells only (maximum concentration 0.12 ppb). No detections of
thiamethoxam at or greater than the analytical method LOQ have been
observed in any groundwater samples collected from the deep monitoring
wells during 47 months of sampling.

4.	DEEM-FCID™ Program and Consumption Information

Thiamethoxam acute and chronic dietary exposure assessments were
conducted using DEEM-FCID™ (Version 2.03), which incorporates
consumption data from USDA’s CSFII, 1994 to 1996, and 1998.  The
1994-96, 1998 data are based on the reported consumption of more than
20,000 individuals over two non-consecutive survey days.  Foods “as
consumed” (such as apple pie) are linked to EPA-defined food
commodities (such as apples, peeled fruit - cooked, fresh/unspecified,
or baked; or wheat flour - cooked, fresh/unspecified, or baked) using
publicly available recipe translation files developed jointly by
USDA/ARS and EPA.  For chronic exposure assessment, consumption data are
averaged for the entire US population, and within population subgroups,
but for acute exposure assessment, they are retained as individual
consumption events (which is why it is appropriate to add residue values
together for the acute assessment, while separate exposure estimates are
summed for the chronic assessment).  Based on analysis of the 1994-96,
1998 CSFII consumption data, which took into account dietary patterns
and survey respondents, HED concluded that it is most appropriate to
report risk for the following population subgroups: the general US
population, all infants (<1 year old), children 1-2, children 3-5,
children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50+
years old.  

For chronic dietary exposure assessment, an estimate of the residue
level in each food or food-form (such as orange or orange juice) on the
food commodity residue list is multiplied by the average daily
consumption estimate for that food/food form.  The resulting residue
consumption estimate for each food/food form is summed with the residue
consumption estimates for all other food/food forms on the commodity
residue list to arrive at the total average estimated exposure. 
Exposure is expressed in mg/kg body weight/day, and as a percent of the
cPAD.  This procedure is performed for each population subgroup.  

For acute exposure assessments, individual one-day food consumption data
are used on an individual-by-individual basis.  The reported consumption
amounts of each food item can be multiplied by a residue point estimate,
and summed to obtain a total daily pesticide exposure for a
deterministic exposure assessment, or “matched” in multiple random
pairings with residue values, and then summed in a probabilistic
assessment.  The resulting distribution of exposures is expressed as a
percentage of the aPAD on both a user (those who reported eating
relevant commodities/food forms) and a per-capita (those who reported
eating the relevant commodities as well as those who did not) basis.  In
accordance with HED policy, per capita exposure and risk are reported
for all tiers of analysis.  However, for Tiers 1 and 2, significant
differences in user versus per capita exposure and risk are identified,
and noted in the risk assessment.  

5.	Toxicological Information

The toxicology database for thiamethoxam is complete.  The scientific
quality is relatively high and the toxicity profile of thiamethoxam can
be characterized for most effects, including potential carcinogenic,
mutagenic, developmental, and neurotoxic effects.

It is recommended that the 10X FQPA safety factor for the protection of
infants and children be reduced to 1X.  There is no quantitative or
qualitative evidence of increased susceptibility of rat or rabbit
fetuses to in utero exposure to thiamethoxam in the developmental
toxicity studies.  The developmental NOAELs are either higher than or
equal to the maternal NOAELs.  The Developmental Neurotoxity (DNT)
Workgroup concluded there was no evidence of increased quantitative
susceptibility in the DNT study in rats, based on evaluation of
additional brain morphometric data for the low- and mid-dose pups
(January 17, 2007 meeting).  

 

Although there is evidence of increased quantitative susceptibility for
male pups of both two generation reproductive studies, NOAELs and LOAELs
were established in these studies, and the Agency selected the NOAEL for
testicular effects in F1 pups as the basis for risk assessment.  The
Agency is confident that the NOAEL selected for risk assessment is
protective of the most sensitive effect (testicular effects) for the
most sensitive subgroup (pups) observed in the toxicological database.  
 

 

In addition, the NOAELs selected for risk assessment are protective of
all toxicological effects observed in the database including
treatment-related changes in the adrenal gland, thyroid, testes and
ovaries.  Thus, the Agency believes the FQPA safety factor can be
reduced to 1X and still be conservatively protective of human health
risk.

Table 3.  Toxicological Doses and Endpoints for Thiomethoxam for Use in
Human Health Risk Assessments.



Exposure/

Scenario	Point of Departure	Uncertainty/ FQPA Safety Factors	Level of
Concern for Risk Assessment	Study and Toxicological Effects

Acute Dietary

All populations including infants and children 	NOAEL =  34.5 mg/kg/day

	UFA= 10x

UFH= 10x

SFFQPA=1

 	aRfD=0.35 mg/kg/day

aPAD=0.35 mg/kg/day	Rat Developmental Neurotoxicity study 

LOAEL = 298.7 mg/kg/day based on delayed sexual maturation in male pups,
and reduced brain morphometric measurements.

Chronic Dietary

All populations including infants and children	NOAEL= 1.2 mg/kg/day 

(MRID 46402904) 	UFA= 10x

UFH= 10x

SFFQPA=1

	cRfD=0.012 mg/kg/day

cPAD=0.012 mg/kg/day	2-Generation reproduction study

LOAEL = 1.8 mg/kg/day based on increased incidence and severity of
tubular atrophy in testes of F1 generation males.

2-Generation reproduction study (46402904) 

LOAEL = 3 (males), not determined (females) mg/kg/day based on sperm
abnormalities in F1 males.

Cancer (oral, dermal, inhalation)	“Not Likely to be Carcinogenic to
Humans” based on convincing evidence that a non-genotoxic mode of
action for liver tumors was established in the mouse and that the
carcinogenic effects are a result of a mode of action dependent on
sufficient amounts of a hepatotoxic metabolite produced persistently. 
Quantification of cancer risk is not required.   



6.	Results/Discussion

As previously stated, for acute and chronic assessments, HED is
concerned when dietary risk exceeds 100% of the PAD.  The DEEM-FCID™
analyses estimate the dietary exposure of the US population and various
population subgroups. 

Table 4.  Summary of Estimated Dietary (Food + Drinking Water) Exposures
and Risk for Thiamethoxam.



Population Subgroup	aPAD, mg/kg	Acute Estimates (95th Percentile)	cPAD,
mg/kg/day	Chronic Estimates



Exposure, mg/kg	Risk, % aPAD

Exposure, mg/kg/day	Risk, % cPAD

U.S. Population	0.35	0.018088	5.2	0.012	0.002795	23

All infants (< 1 year)	0.35	0.033163	9.5	0.012	0.003002	25

Children 1-2 yrs	0.35	0.032980	9.4	0.012	0.005065	42

Children 3-5 yrs	0.35	0.026607	7.6	0.012	0.004446	37

Children 6-12 yrs	0.35	0.018827	5.4	0.012	0.003196	27

Youth 13-19 yrs	0.35	0.014308	4.1	0.012	0.002308	19

Adults 20-49 yrs	0.35	0.016273	4.7	0.012	0.002567	21

Adults 50+ yrs	0.35	0.016610	4.8	0.012	0.002625	22

Females 13-49 yrs	0.35	0.016146	4.6	0.012	0.002595	22

The population subgroup with the highest estimated exposure/risk is
bolded.

oncerned when dietary risk exceeds 100% of the PAD.  The DEEM-FCID™
analyses estimate the dietary exposure of the U.S. population and
various population subgroups.  The results reported in Table 6 are for
the general U.S. population, all infants (<1 year old), children 1-2,
children 3-5, children 6-12, youth 13-19, females 13-49, adults 20-49,
and adults 50+ years.  The acute results summarized in Table 6 are for
the 95th percentile of exposure.  A complete listing of acute and
chronic exposure and risk estimates can be found in Attachments 2 and 3,
respectively.

The analyses indicate that the requested uses of thiamethoxam, coupled
with currently registered uses, will result in acute and chronic dietary
(food + drinking water) exposures that are below HED’s level of
concern for all population subgroups, including those of infants and
children.

Typically, HED uses tolerance-level residues in its most conservative
assessments.  For this reason, the acute assessment is considered to be
an unrefined assessment (i.e., screening level) and evaluation at the
95th percentile of exposure is appropriate.  The acute assessment
indicates that All Infants are the most highly-exposed subgroup,
utilizing 9.5% of the aPAD, while the general US population utilizes
5.2% of the aPAD; all risk estimates are below HED’s level of concern
(Table 6).  Similarly, risk estimates for the chronic dietary exposure
analysis are below HED’s level of concern, with Children 1-2 years
being the most highly-exposed subgroup, utilizing 42% of the chronic
population-adjusted dose (cPAD), while the general U.S. population
utilizes 23% of the cPAD.

7.	Characterization of Inputs/Outputs

This assessment is based on tolerance level or field trial residues and
assumes 100% CT.  The exposure values represent high-end estimates and
should be considered highly conservative, health-protective estimates of
dietary exposure and risk.  The Tier I Rice Model used to generate the
EDWCs is expected to generate conservative estimates that exceed peak
measured concentrations of pesticides in water bodies well downstream of
rice paddies by less than one order of magnitude to multiple orders of
magnitude.

8.	Conclusions

Based on highly conservative assumptions, there are no dietary (food +
drinking water) exposure considerations that would preclude registration
of thiamethoxam on onion, dry bulb.  These analyses also support
removing the geographical use limitation for the foliar treatment of
barley; as these assessments assume 100% crop treated for barley.

9.	List of Attachments

Attachment 1.  Input file for the acute dietary exposure analyses of
thiamethoxam.

Attachment 2.  Input file for the chronic dietary exposure analyses of
thiamethoxam.

Attachment 3.  Summary of the acute dietary exposure analysis for
thiamethoxam.

Attachment 4.  Summary of the chronic dietary exposure analysis for
thiamethoxam.

Attachment 1.	Input File for the Acute Dietary Exposure Estimates.

U.S. Environmental Protection Agency                                
Ver. 2.02

DEEM-FCID Acute analysis for THIAMETHOXAM

Residue file name: C:\Documents and Settings\dmcneill\My
Documents\Thiamethoxam\060109 2010 Acute T+Water.R98

Analysis Date 03-04-2010             Residue file dated:
03-04-2010/14:31:37/8

Reference dose (aRfD) = 0.35 mg/kg bw/day

Comment: Acute and Chronic RfDs = aPAD and cPAD

------------------------------------------------------------------------
--------

  EPA    Crop                                   Def Res     Adj.Factors 
 Comment

  Code    Grp  Food Name                         (ppm)       #1    #2   

-------- ---- -------------------------------  ----------  ------ ------
 -------

14000030 14   Almond                             0.020000   1.000  1.000

14000031 14   Almond-babyfood                    0.020000   1.000  1.000

14000040 14   Almond, oil                        0.020000   1.000  1.000

14000041 14   Almond, oil-babyfood               0.020000   1.000  1.000

04010050 4A   Amaranth, leafy                    4.000000   1.000  1.000

11000070 11   Apple, fruit with peel             0.200000   1.000  1.000

11000080 11   Apple, peeled fruit                0.200000   1.000  1.000

11000081 11   Apple, peeled fruit-babyfood       0.200000   1.000  1.000

11000090 11   Apple, dried                       0.200000   8.000  1.000

11000091 11   Apple, dried-babyfood              0.200000   8.000  1.000

11000100 11   Apple, juice                       0.200000   0.750  1.000

11000101 11   Apple, juice-babyfood              0.200000   0.750  1.000

11000110 11   Apple, sauce                       0.200000   1.000  1.000

11000111 11   Apple, sauce-babyfood              0.200000   1.000  1.000

12000120 12   Apricot                            0.500000   1.000  1.000

12000121 12   Apricot-babyfood                   0.500000   1.000  1.000

12000130 12   Apricot, dried                     0.500000   6.000  1.000

12000140 12   Apricot, juice                     0.500000   1.000  1.000

12000141 12   Apricot, juice-babyfood            0.500000   1.000  1.000

95000160 O    Artichoke, globe                   0.450000   1.000  1.000

04010180 4A   Arugula                            4.000000   1.000  1.000

95000200 O    Avocado                            0.400000   1.000  1.000

09020210 9B   Balsam pear                        0.200000   1.000  1.000

15000250 15   Barley, pearled barley             0.300000   0.300 
1.000D28170

          Full comment: D281702

15000251 15   Barley, pearled barley-babyfood    0.300000   0.300 
1.000D28170

          Full comment: D281702

15000260 15   Barley, flour                      0.300000   0.100 
1.000D28170

          Full comment: D281702

15000261 15   Barley, flour-babyfood             0.300000   0.100 
1.000D28170

          Full comment: D281702

15000270 15   Barley, bran                       0.300000   0.300 
1.000D28170

          Full comment: D281702

06030300 6C   Bean, black, seed                  0.020000   1.000  1.000

06020310 6B   Bean, broad, succulent             0.020000   1.000  1.000

06030320 6C   Bean, broad, seed                  0.020000   1.000  1.000

06020330 6B   Bean, cowpea, succulent            0.020000   1.000  1.000

06030340 6C   Bean, cowpea, seed                 0.020000   1.000  1.000

06030350 6C   Bean,  great northern, seed        0.020000   1.000  1.000

06030360 6C   Bean, kidney, seed                 0.020000   1.000  1.000

06020370 6B   Bean, lima, succulent              0.020000   1.000  1.000

06030380 6C   Bean, lima, seed                   0.020000   1.000  1.000

06030390 6C   Bean, mung, seed                   0.020000   1.000  1.000

06030400 6C   Bean, navy, seed                   0.020000   1.000  1.000

06030410 6C   Bean, pink, seed                   0.020000   1.000  1.000

06030420 6C   Bean, pinto, seed                  0.020000   1.000  1.000

06010430 6A   Bean, snap, succulent              0.020000   1.000  1.000

06010431 6A   Bean, snap, succulent-babyfood     0.020000   1.000  1.000

21000440 M    Beef, meat                         0.020000   1.000  1.000

21000441 M    Beef, meat-babyfood                0.020000   1.000  1.000

21000450 M    Beef, meat, dried                  0.020000   1.920  1.000

21000460 M    Beef, meat byproducts              0.040000   1.000  1.000

21000461 M    Beef, meat byproducts-babyfood     0.040000   1.000  1.000

21000480 M    Beef, kidney                       0.040000   1.000  1.000

21000490 M    Beef, liver                        0.040000   1.000  1.000

21000491 M    Beef, liver-babyfood               0.040000   1.000  1.000

01010500 1AB  Beet, garden, roots                0.050000   1.000 
1.000D35744

          Full comment: D357449, recommended tol.

01010501 1AB  Beet, garden, roots-babyfood       0.050000   1.000  1.000

01010520 1A   Beet, sugar                        0.050000   1.000  1.000

01010521 1A   Beet, sugar-babyfood               0.050000   1.000  1.000

01010530 1A   Beet, sugar, molasses              0.050000   1.000  1.000

01010531 1A   Beet, sugar, molasses-babyfood     0.050000   1.000  1.000

13010550 13A  Blackberry                         0.350000   1.000  1.000

13010560 13A  Blackberry, juice                  0.350000   1.000  1.000

13010561 13A  Blackberry, juice-babyfood         0.350000   1.000  1.000

13020570 13B  Blueberry                          0.300000   1.000  1.000

13020571 13B  Blueberry-babyfood                 0.300000   1.000  1.000

13010580 13A  Boysenberry                        0.350000   1.000  1.000

14000590 14   Brazil nut                         0.020000   1.000  1.000

05010610 5A   Broccoli                           4.500000   1.000  1.000

05010611 5A   Broccoli-babyfood                  4.500000   1.000  1.000

05010620 5A   Broccoli, Chinese                  4.500000   1.000  1.000

05020630 5B   Broccoli raab                      3.000000   1.000  1.000

05010640 5A   Brussels sprouts                   4.500000   1.000  1.000

15000650 15   Buckwheat                          0.020000   1.000  1.000

15000660 15   Buckwheat, flour                   0.020000   1.000  1.000

01010670 1AB  Burdock                            0.050000   1.000  1.000

14000680 14   Butternut                          0.020000   1.000  1.000

05010690 5A   Cabbage                            4.500000   1.000  1.000

05020700 5B   Cabbage, Chinese, bok choy         3.000000   1.000  1.000

05010710 5A   Cabbage, Chinese, napa             4.500000   1.000  1.000

05010720 5A   Cabbage, Chinese, mustard          4.500000   1.000  1.000

95000740 O    Canistel                           0.400000   1.000  1.000

09010750 9A   Cantaloupe                         0.200000   1.000  1.000

04020760 4B   Cardoon                            4.000000   1.000  1.000

01010780 1AB  Carrot                             0.050000   1.000  1.000

01010781 1AB  Carrot-babyfood                    0.050000   1.000  1.000

01010790 1AB  Carrot, juice                      0.050000   1.000  1.000

09010800 9A   Casaba                             0.200000   1.000  1.000

14000810 14   Cashew                             0.020000   1.000  1.000

05010830 5A   Cauliflower                        4.500000   1.000  1.000

01010840 1AB  Celeriac                           0.050000   1.000  1.000

04020850 4B   Celery                             4.000000   1.000  1.000

04020851 4B   Celery-babyfood                    4.000000   1.000  1.000

04020860 4B   Celery, juice                      4.000000   1.000  1.000

04020870 4B   Celtuce                            4.000000   1.000  1.000

09020880 9B   Chayote, fruit                     0.200000   1.000  1.000

95000890 O    Cherimoya                          0.110000   1.000  1.000

12000900 12   Cherry                             0.500000   1.000  1.000

12000901 12   Cherry-babyfood                    0.500000   1.000  1.000

12000910 12   Cherry, juice                      0.500000   1.500  1.000

12000911 12   Cherry, juice-babyfood             0.500000   1.500  1.000

14000920 14   Chestnut                           0.020000   1.000  1.000

06030980 6C   Chickpea, seed                     0.020000   1.000  1.000

06030981 6C   Chickpea, seed-babyfood            0.020000   1.000  1.000

06030990 6C   Chickpea, flour                    0.020000   1.000  1.000

01011000 1AB  Chicory, roots                     0.050000   1.000  1.000

09021020 9B   Chinese waxgourd                   0.200000   1.000  1.000

04011040 4A   Chrysanthemum, garland             4.000000   1.000  1.000

10001060 10   Citrus citron                      0.400000   1.000 
1.000D34870

          Full comment: D348703

10001070 10   Citrus hybrids                     0.400000   1.000  1.000

10001080 10   Citrus, oil                        0.400000   0.600 
1.000D34927

          Full comment: D349272

95001150 O    Coffee, roasted bean               0.050000   1.000  1.000

95001160 O    Coffee, instant                    0.050000   1.000  1.000

05021170 5B   Collards                           3.000000   1.000  1.000

15001200 15   Corn, field, flour                 0.020000   1.000  1.000

15001201 15   Corn, field, flour-babyfood        0.020000   1.000  1.000

15001210 15   Corn, field, meal                  0.020000   1.000  1.000

15001211 15   Corn, field, meal-babyfood         0.020000   1.000  1.000

15001220 15   Corn, field, bran                  0.020000   1.000  1.000

15001230 15   Corn, field, starch                0.020000   1.000  1.000

15001231 15   Corn, field, starch-babyfood       0.020000   1.000  1.000

15001240 15   Corn, field, syrup                 0.020000   1.500  1.000

15001241 15   Corn, field, syrup-babyfood        0.020000   1.500  1.000

15001250 15   Corn, field, oil                   0.020000   1.000  1.000

15001251 15   Corn, field, oil-babyfood          0.020000   1.000  1.000

15001260 15   Corn, pop                          0.020000   1.000  1.000

15001270 15   Corn, sweet                        0.020000   1.000  1.000

15001271 15   Corn, sweet-babyfood               0.020000   1.000  1.000

95001280 O    Cottonseed, oil                    0.100000   1.000  1.000

95001281 O    Cottonseed, oil-babyfood           0.100000   1.000  1.000

11001290 11   Crabapple                          0.200000   1.000  1.000

95001300 O    Cranberry                          0.020000   1.000  1.000

95001301 O    Cranberry-babyfood                 0.020000   1.000  1.000

95001310 O    Cranberry, dried                   0.020000   1.000  1.000

95001320 O    Cranberry, juice                   0.020000   1.100  1.000

95001321 O    Cranberry, juice-babyfood          0.020000   1.100  1.000

04011330 4A   Cress, garden                      4.000000   1.000  1.000

04011340 4A   Cress, upland                      4.000000   1.000  1.000

09021350 9B   Cucumber                           0.200000   1.000  1.000

13021360 13B  Currant                            0.200000   1.000  1.000

13021370 13B  Currant, dried                     0.200000   1.000  1.000

04011380 4A   Dandelion, leaves                  4.000000   1.000  1.000

13011420 13A  Dewberry                           0.350000   1.000  1.000

08001480 8    Eggplant                           0.250000   1.000  1.000

13021490 13B  Elderberry                         0.200000   1.000  1.000

04011500 4A   Endive                             4.000000   1.000  1.000

04021520 4B   Fennel, Florence                   4.000000   1.000  1.000

14001550 14   Filbert                            0.020000   1.000  1.000

14001560 14   Filbert, oil                       0.020000   1.000  1.000

20001630 20   Flaxseed, oil                      0.020000   1.000  1.000

01011680 1AB  Ginseng, dried                     0.050000   1.000  1.000

23001690 M    Goat, meat                         0.020000   1.000  1.000

23001700 M    Goat, meat byproducts              0.040000   1.000  1.000

23001720 M    Goat, kidney                       0.040000   1.000  1.000

23001730 M    Goat, liver                        0.040000   1.000  1.000

13021740 13B  Gooseberry                         0.200000   1.000  1.000

95001750 O    Grape                              0.200000   1.000  1.000

95001760 O    Grape, juice                       0.200000   1.100 
1.000D28170

          Full comment: D281702

95001761 O    Grape, juice-babyfood              0.200000   1.100  1.000

95001770 O    Grape, leaves                      0.200000   1.000  1.000

95001780 O    Grape, raisin                      0.200000   2.300 
1.000D28170

          Full comment: D281702

95001790 O    Grape, wine and sherry             0.200000   1.000  1.000

10001800 10   Grapefruit                         0.400000   1.000  1.000

10001810 10   Grapefruit, juice                  0.400000   0.600 
1.000D34927

          Full comment: D349272

06031820 6C   Guar, seed                         0.020000   1.000  1.000

06031821 6C   Guar, seed-babyfood                0.020000   1.000  1.000

14001850 14   Hickory nut                        0.020000   1.000  1.000

09011870 9A   Honeydew melon                     0.200000   1.000  1.000

95001880 O    Hop                                0.100000   1.000  1.000

24001890 M    Horse, meat                        0.020000   1.000  1.000

01011900 1AB  Horseradish                        0.050000   1.000  1.000

13021910 13B  Huckleberry                        0.200000   1.000  1.000

05021940 5B   Kale                               3.000000   1.000  1.000

05011960 5A   Kohlrabi                           4.500000   1.000  1.000

10001970 10   Kumquat                            0.400000   1.000  1.000

10001990 10   Lemon                              0.400000   1.000  1.000

10002000 10   Lemon, juice                       0.400000   0.600 
1.000D34827

          Full comment: D348272

10002001 10   Lemon, juice-babyfood              0.400000   0.600 
1.000D34927

          Full comment: D349272

10002010 10   Lemon, peel                        0.400000   1.000  1.000

06032030 6C   Lentil, seed                       0.020000   1.000  1.000

04012040 4A   Lettuce, head                      4.000000   1.000  1.000

04012050 4A   Lettuce, leaf                      4.000000   1.000  1.000

10002060 10   Lime                               0.400000   1.000  1.000

10002070 10   Lime, juice                        0.400000   0.600 
1.000D34827

          Full comment: D348272

10002071 10   Lime, juice-babyfood               0.400000   0.600 
1.000D34927

          Full comment: D349272

13012080 13A  Loganberry                         0.350000   1.000  1.000

11002100 11   Loquat                             0.200000   1.000  1.000

14002130 14   Macadamia nut                      0.020000   1.000  1.000

95002150 O    Mango                              0.400000   1.000  1.000

95002151 O    Mango-babyfood                     0.400000   1.000  1.000

95002160 O    Mango, dried                       0.400000   1.000  1.000

95002170 O    Mango, juice                       0.400000   1.000  1.000

95002171 O    Mango, juice-babyfood              0.400000   1.000  1.000

28002210 M    Meat, game                         0.020000   1.000  1.000

27002220 D    Milk, fat                          0.020000   1.000  1.000

27002221 D    Milk, fat - baby food/infant for   0.020000   1.000  1.000

27012230 D    Milk, nonfat solids                0.020000   1.000  1.000

27012231 D    Milk, nonfat solids-baby food/in   0.020000   1.000  1.000

27022240 D    Milk, water                        0.020000   1.000  1.000

27022241 D    Milk, water-babyfood/infant form   0.020000   1.000  1.000

27032251 D    Milk, sugar (lactose)-baby food/   0.020000   1.000  1.000

15002260 15   Millet, grain                      0.020000   1.000  1.000

05022290 5B   Mustard greens                     3.000000   1.000  1.000

12002300 12   Nectarine                          0.500000   1.000  1.000

15002310 15   Oat, bran                          0.020000   1.000  1.000

15002320 15   Oat, flour                         0.020000   1.000  1.000

15002321 15   Oat, flour-babyfood                0.020000   1.000  1.000

15002330 15   Oat, groats/rolled oats            0.020000   1.000  1.000

15002331 15   Oat, groats/rolled oats-babyfood   0.020000   1.000  1.000

08002340 8    Okra                               0.250000   1.000  1.000

03002370 3    Onion, dry bulb                    0.030000   1.000  1.000

03002371 3    Onion, dry bulb-babyfood           0.030000   1.000  1.000

03002380 3    Onion, dry bulb, dried             0.030000   9.000  1.000

03002381 3    Onion, dry bulb, dried-babyfood    0.030000   9.000  1.000

10002400 10   Orange                             0.400000   1.000  1.000

10002410 10   Orange, juice                      0.400000   0.600 
1.000D34927

          Full comment: D349272

10002411 10   Orange, juice-babyfood             0.400000   0.600 
1.000D34827

          Full comment: D348272

10002420 10   Orange, peel                       0.400000   1.000  1.000

95002450 O    Papaya                             0.400000   1.000  1.000

95002451 O    Papaya-babyfood                    0.400000   1.000  1.000

95002460 O    Papaya, dried                      0.400000   1.800  1.000

95002470 O    Papaya, juice                      0.400000   1.500  1.000

04012480 4A   Parsley, leaves                    4.000000   1.000  1.000

01012500 1AB  Parsley, turnip rooted             0.050000   1.000  1.000

01012510 1AB  Parsnip                            0.050000   1.000  1.000

01012511 1AB  Parsnip-babyfood                   0.050000   1.000  1.000

06022550 6B   Pea, succulent                     0.020000   1.000  1.000

06022551 6B   Pea, succulent-babyfood            0.020000   1.000  1.000

06032560 6C   Pea, dry                           0.020000   1.000  1.000

06032561 6C   Pea, dry-babyfood                  0.020000   1.000  1.000

06012570 6A   Pea, edible podded, succulent      0.020000   1.000  1.000

06032580 6C   Pea, pigeon, seed                  0.020000   1.000  1.000

06022590 6B   Pea, pigeon, succulent             0.020000   1.000  1.000

12002600 12   Peach                              0.500000   1.000  1.000

12002601 12   Peach-babyfood                     0.500000   1.000  1.000

12002610 12   Peach, dried                       0.500000   7.000  1.000

12002611 12   Peach, dried-babyfood              0.500000   7.000  1.000

12002620 12   Peach, juice                       0.500000   1.000  1.000

12002621 12   Peach, juice-babyfood              0.500000   1.000  1.000

11002660 11   Pear                               0.200000   1.000  1.000

11002661 11   Pear-babyfood                      0.200000   1.000  1.000

11002670 11   Pear, dried                        0.200000   6.250  1.000

11002680 11   Pear, juice                        0.200000   1.000  1.000

11002681 11   Pear, juice-babyfood               0.200000   1.000  1.000

14002690 14   Pecan                              0.020000   1.000  1.000

08002700 8    Pepper, bell                       0.250000   1.000  1.000

08002701 8    Pepper, bell-babyfood              0.250000   1.000  1.000

08002710 8    Pepper, bell, dried                0.250000   1.000  1.000

08002711 8    Pepper, bell, dried-babyfood       0.250000   1.000  1.000

08002720 8    Pepper, nonbell                    0.250000   1.000  1.000

08002721 8    Pepper, nonbell-babyfood           0.250000   1.000  1.000

08002730 8    Pepper, nonbell, dried             0.250000   1.000  1.000

95002750 O    Peppermint                         1.500000   1.000  1.000

95002760 O    Peppermint, oil                    1.500000   0.050  1.000

14002820 14   Pistachio                          0.020000   1.000  1.000

12002850 12   Plum                               0.500000   1.000  1.000

12002851 12   Plum-babyfood                      0.500000   1.000  1.000

12002860 12   Plum, prune, fresh                 0.500000   1.000  1.000

12002861 12   Plum, prune, fresh-babyfood        0.500000   1.000  1.000

12002870 12   Plum, prune, dried                 0.500000   5.000  1.000

12002871 12   Plum, prune, dried-babyfood        0.500000   5.000  1.000

12002880 12   Plum, prune, juice                 0.500000   1.400  1.000

12002881 12   Plum, prune, juice-babyfood        0.500000   1.400  1.000

25002900 M    Pork, meat                         0.020000   1.000  1.000

25002901 M    Pork, meat-babyfood                0.020000   1.000  1.000

25002920 M    Pork, meat byproducts              0.020000   1.000  1.000

25002921 M    Pork, meat byproducts-babyfood     0.020000   1.000  1.000

25002940 M    Pork, kidney                       0.020000   1.000  1.000

25002950 M    Pork, liver                        0.020000   1.000  1.000

01032960 1C   Potato, chips                      0.250000   1.200  1.000

01032970 1C   Potato, dry (granules/ flakes)     0.250000   1.700  1.000

01032971 1C   Potato, dry (granules/ flakes)-b   0.250000   1.700  1.000

01032980 1C   Potato, flour                      0.250000   1.700  1.000

01032981 1C   Potato, flour-babyfood             0.250000   1.700  1.000

01032990 1C   Potato, tuber, w/peel              0.250000   1.000  1.000

01032991 1C   Potato, tuber, w/peel-babyfood     0.250000   1.000  1.000

01033000 1C   Potato, tuber, w/o peel            0.250000   1.000  1.000

01033001 1C   Potato, tuber, w/o peel-babyfood   0.250000   1.000  1.000

10003070 10   Pummelo                            0.400000   1.000  1.000

09023080 9B   Pumpkin                            0.200000   1.000  1.000

09023090 9B   Pumpkin, seed                      0.200000   1.000  1.000

11003100 11   Quince                             0.200000   1.000  1.000

29003120 M    Rabbit, meat                       0.020000   1.000  1.000

04013130 4A   Radicchio                          4.000000   1.000  1.000

01013140 1AB  Radish, roots                      0.050000   1.000  1.000

02003150 2    Radish, tops                       0.800000   1.000  1.000

01013160 1AB  Radish, Oriental, roots            0.050000   1.000  1.000

02003170 2    Radish, Oriental, tops             0.800000   1.000  1.000

05023180 5B   Rape greens                        3.000000   1.000  1.000

20003190 20   Rapeseed, oil                      0.020000   1.000  1.000

20003191 20   Rapeseed, oil-babyfood             0.020000   1.000  1.000

13013200 13A  Raspberry                          0.350000   1.000  1.000

13013201 13A  Raspberry-babyfood                 0.350000   1.000  1.000

13013210 13A  Raspberry, juice                   0.350000   1.000  1.000

13013211 13A  Raspberry, juice-babyfood          0.350000   1.000  1.000

04023220 4B   Rhubarb                            4.000000   1.000  1.000

15003230 15   Rice, white                        0.020000   1.000  1.000

15003231 15   Rice, white-babyfood               0.020000   1.000  1.000

15003240 15   Rice, brown                        0.020000   1.000  1.000

15003241 15   Rice, brown-babyfood               0.020000   1.000  1.000

15003250 15   Rice, flour                        0.020000   1.000  1.000

15003251 15   Rice, flour-babyfood               0.020000   1.000  1.000

15003260 15   Rice, bran                         0.020000   0.900 
1.000D35744

          Full comment: D357449

15003261 15   Rice, bran-babyfood                0.020000   0.900 
1.000D35744

          Full comment: D357449

01013270 1AB  Rutabaga                           0.050000   1.000  1.000

15003280 15   Rye, grain                         0.020000   1.000  1.000

15003290 15   Rye, flour                         0.020000   1.000  1.000

20003300 20   Safflower, oil                     0.020000   1.000  1.000

20003301 20   Safflower, oil-babyfood            0.020000   1.000  1.000

01013310 1AB  Salsify, roots                     0.050000   1.000  1.000

95003330 O    Sapote, Mamey                      0.400000   1.000  1.000

26003390 M    Sheep, meat                        0.020000   1.000  1.000

26003391 M    Sheep, meat-babyfood               0.020000   1.000  1.000

26003400 M    Sheep, meat byproducts             0.040000   1.000  1.000

26003420 M    Sheep, kidney                      0.040000   1.000  1.000

26003430 M    Sheep, liver                       0.040000   1.000  1.000

15003440 15   Sorghum, grain                     0.020000   1.000  1.000

15003450 15   Sorghum, syrup                     0.020000   1.000  1.000

06003470 6    Soybean, seed                      0.020000   1.000  1.000

06003480 6    Soybean, flour                     0.020000   1.000  1.000

06003481 6    Soybean, flour-babyfood            0.020000   1.000  1.000

06003490 6    Soybean, soy milk                  0.020000   1.000  1.000

06003491 6    Soybean, soy milk-babyfood or in   0.020000   1.000  1.000

06003500 6    Soybean, oil                       0.020000   1.000  1.000

06003501 6    Soybean, oil-babyfood              0.020000   1.000  1.000

95003520 O    Spearmint                          1.500000   1.000  1.000

95003530 O    Spearmint, oil                     1.500000   0.050 
1.000D28170

          Full comment: D281702

04013550 4A   Spinach                            4.000000   1.000  1.000

04013551 4A   Spinach-babyfood                   4.000000   1.000  1.000

09023560 9B   Squash, summer                     0.200000   1.000  1.000

09023561 9B   Squash, summer-babyfood            0.200000   1.000  1.000

09023570 9B   Squash, winter                     0.200000   1.000  1.000

09023571 9B   Squash, winter-babyfood            0.200000   1.000  1.000

95003590 O    Strawberry                         0.300000   1.000  1.000

95003591 O    Strawberry-babyfood                0.300000   1.000  1.000

95003600 O    Strawberry, juice                  0.300000   1.000  1.000

95003601 O    Strawberry, juice-babyfood         0.300000   1.000  1.000

20003640 20   Sunflower, seed                    0.020000   1.000  1.000

20003650 20   Sunflower, oil                     0.020000   1.000  1.000

20003651 20   Sunflower, oil-babyfood            0.020000   1.000  1.000

01033660 1CD  Sweet potato                       0.020000   1.000  1.000

01033661 1CD  Sweet potato-babyfood              0.020000   1.000  1.000

04023670 4B   Swiss chard                        4.000000   1.000  1.000

10003690 10   Tangerine                          0.400000   1.000  1.000

10003700 10   Tangerine, juice                   0.400000   0.600 
1.000D34827

          Full comment: D348272

01033710 1CD  Tanier, corm                       0.020000   1.000  1.000

08003740 8    Tomatillo                          0.250000   1.000  1.000

08003750 8    Tomato                             0.250000   1.000  1.000

08003751 8    Tomato-babyfood                    0.250000   1.000  1.000

08003760 8    Tomato, paste                      0.800000   1.000 
1.000Tol.

08003761 8    Tomato, paste-babyfood             0.800000   1.000 
1.000Tol.

08003770 8    Tomato, puree                      0.250000   1.700  1.000

08003771 8    Tomato, puree-babyfood             0.250000   1.700  1.000

08003780 8    Tomato, dried                      0.250000  14.300  1.000

08003781 8    Tomato, dried-babyfood             0.250000  14.300  1.000

08003790 8    Tomato, juice                      0.250000   1.500  1.000

15003810 15   Triticale, flour                   0.020000   1.000  1.000

15003811 15   Triticale, flour-babyfood          0.020000   1.000  1.000

01033870 1CD  Turmeric                           0.020000   1.000  1.000

01013880 1AB  Turnip, roots                      0.050000   1.000  1.000

05023890 5B   Turnip, greens                     3.000000   1.000  1.000

14003910 14   Walnut                             0.020000   1.000  1.000

86010000 O    Water, direct, all sources         0.131770   1.000  1.000

86020000 O    Water, indirect, all sources       0.131770   1.000  1.000

09013990 9A   Watermelon                         0.200000   1.000  1.000

09014000 9A   Watermelon, juice                  0.200000   1.000  1.000

15004010 15   Wheat, grain                       0.020000   1.000  1.000

15004011 15   Wheat, grain-babyfood              0.020000   1.000  1.000

15004020 15   Wheat, flour                       0.020000   1.000  1.000

15004021 15   Wheat, flour-babyfood              0.020000   1.000  1.000

15004030 15   Wheat, germ                        0.020000   1.000  1.000

15004040 15   Wheat, bran                        0.020000   1.000  1.000

15004050 15   Wild rice                          0.020000   1.000  1.000

01034060 1CD  Yam, true                          0.020000   1.000  1.000

01034070 1CD  Yam bean                           0.020000   1.000  1.000

Attachment 2.	Input File for the Chronic Dietary Exposure Estimates.

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for THIAMETHOXAM                      
1994-98 data

Residue file: C:\Documents and Settings\dmcneill\My
Documents\Thiamethoxam\060109 2010 T+Water.R98

                                                           Adjust. #2
NOT used

Analysis Date 03-04-2010             Residue file dated:
03-04-2010/14:33:35/8

Reference dose (RfD) = 0.012 mg/kg bw/day

Comment:Acute and Chronic RfDs = aPAD and cPAD

------------------------------------------------------------------------
--------

Food Crop                                       Residue      
Adj.Factors      Comment

EPA Code  Grp  Food Name                          (ppm)       

                                                             #1        
#2 

-------- ---- -------------------------------   ---------- ------    
------   -------

14000030 14   Almond                             0.010000   1.000     
1.000   D34927

  Full comment: D349272

14000031 14   Almond-babyfood                    0.010000   1.000     
1.000   

14000040 14   Almond, oil                        0.010000   1.000     
1.000   

14000041 14   Almond, oil-babyfood               0.010000   1.000     
1.000   

04010050 4A   Amaranth, leafy                    4.000000   1.000     
1.000   

11000070 11   Apple, fruit with peel             0.060000   1.000     
1.000   D28170

  Full comment: D281702 & D265079

11000080 11   Apple, peeled fruit                0.060000   1.000     
1.000   

11000081 11   Apple, peeled fruit-babyfood       0.060000   1.000     
1.000   

11000090 11   Apple, dried                       0.060000   8.000     
1.000   

11000091 11   Apple, dried-babyfood              0.060000   8.000     
1.000   

11000100 11   Apple, juice                       0.060000   0.750     
1.000   

11000101 11   Apple, juice-babyfood              0.060000   0.750     
1.000   

11000110 11   Apple, sauce                       0.060000   1.000     
1.000   

11000111 11   Apple, sauce-babyfood              0.060000   1.000     
1.000   

12000120 12   Apricot                            0.210000   1.000     
1.000   W. Cut

  Full comment: W. Cuthchin 12/10/03 DERs

12000121 12   Apricot-babyfood                   0.210000   1.000     
1.000   

12000130 12   Apricot, dried                     0.210000   6.000     
1.000   

12000140 12   Apricot, juice                     0.210000   1.000     
1.000   

12000141 12   Apricot, juice-babyfood            0.210000   1.000     
1.000   

95000160 O    Artichoke, globe                   0.190000   1.000     
1.000   D28170

  Full comment: D281702/D325447

04010180 4A   Arugula                            4.000000   1.000     
1.000   

95000200 O    Avocado                            0.110000   1.000     
1.000   D35744

  Full comment: D357449/D357450

09020210 9B   Balsam pear                        0.200000   1.000     
1.000   

15000250 15   Barley, pearled barley             0.086000   0.300     
1.000   D28170

  Full comment: D281702/D325447

15000251 15   Barley, pearled barley-babyfood    0.086000   0.300     
1.000   

15000260 15   Barley, flour                      0.086000   0.100     
1.000   

15000261 15   Barley, flour-babyfood             0.086000   0.100     
1.000   

15000270 15   Barley, bran                       0.086000   0.300     
1.000   

06030300 6C   Bean, black, seed                  0.010000   1.000     
1.000   S,. Ta

  Full comment: S,. Tayayin, 26 Nov 2002

06020310 6B   Bean, broad, succulent             0.010000   1.000     
1.000   

06030320 6C   Bean, broad, seed                  0.010000   1.000     
1.000   

06020330 6B   Bean, cowpea, succulent            0.010000   1.000     
1.000   

06030340 6C   Bean, cowpea, seed                 0.010000   1.000     
1.000   

06030350 6C   Bean,  great northern, seed        0.010000   1.000     
1.000   

06030360 6C   Bean, kidney, seed                 0.010000   1.000     
1.000   

06020370 6B   Bean, lima, succulent              0.010000   1.000     
1.000   

06030380 6C   Bean, lima, seed                   0.010000   1.000     
1.000   

06030390 6C   Bean, mung, seed                   0.010000   1.000     
1.000   

06030400 6C   Bean, navy, seed                   0.010000   1.000     
1.000   

06030410 6C   Bean, pink, seed                   0.010000   1.000     
1.000   

06030420 6C   Bean, pinto, seed                  0.010000   1.000     
1.000   

06010430 6A   Bean, snap, succulent              0.010000   1.000     
1.000   

06010431 6A   Bean, snap, succulent-babyfood     0.010000   1.000     
1.000   

21000440 M    Beef, meat                         0.020000   1.000     
1.000   

21000441 M    Beef, meat-babyfood                0.020000   1.000     
1.000   

21000450 M    Beef, meat, dried                  0.020000   1.920     
1.000   

21000460 M    Beef, meat byproducts              0.040000   1.000     
1.000   Rec. T

  Full comment: Rec. Tol.

21000461 M    Beef, meat byproducts-babyfood     0.040000   1.000     
1.000   

21000480 M    Beef, kidney                       0.040000   1.000     
1.000   

21000490 M    Beef, liver                        0.040000   1.000     
1.000   

21000491 M    Beef, liver-babyfood               0.040000   1.000     
1.000   

01010500 1AB  Beet, garden, roots                0.050000   1.000     
1.000   

01010501 1AB  Beet, garden, roots-babyfood       0.050000   1.000     
1.000   

01010520 1A   Beet, sugar                        0.050000   1.000     
1.000   

01010521 1A   Beet, sugar-babyfood               0.050000   1.000     
1.000   

01010530 1A   Beet, sugar, molasses              0.050000   1.000     
1.000   

01010531 1A   Beet, sugar, molasses-babyfood     0.050000   1.000     
1.000   

13010550 13A  Blackberry                         0.120000   1.000     
1.000   D28170

  Full comment: D281702

13010560 13A  Blackberry, juice                  0.120000   1.000     
1.000   

13010561 13A  Blackberry, juice-babyfood         0.120000   1.000     
1.000   

13020570 13B  Blueberry                          0.300000   1.000     
1.000   

13020571 13B  Blueberry-babyfood                 0.300000   1.000     
1.000   

13010580 13A  Boysenberry                        0.120000   1.000     
1.000   

14000590 14   Brazil nut                         0.010000   1.000     
1.000   

05010610 5A   Broccoli                           0.980000   1.000     
1.000   D28170

  Full comment: D281702

05010611 5A   Broccoli-babyfood                  0.980000   1.000     
1.000   

05010620 5A   Broccoli, Chinese                  0.980000   1.000     
1.000   

05020630 5B   Broccoli raab                      0.820000   1.000     
1.000   

05010640 5A   Brussels sprouts                   0.980000   1.000     
1.000   

15000650 15   Buckwheat                          0.020000   1.000     
1.000   

15000660 15   Buckwheat, flour                   0.020000   1.000     
1.000   

01010670 1AB  Burdock                            0.050000   1.000     
1.000   

14000680 14   Butternut                          0.010000   1.000     
1.000   

05010690 5A   Cabbage                            0.980000   1.000     
1.000   

05020700 5B   Cabbage, Chinese, bok choy         0.820000   1.000     
1.000   D28170

  Full comment: D281702

05010710 5A   Cabbage, Chinese, napa             0.980000   1.000     
1.000   

05010720 5A   Cabbage, Chinese, mustard          0.980000   1.000     
1.000   

95000740 O    Canistel                           0.400000   1.000     
1.000   

09010750 9A   Cantaloupe                         0.200000   1.000     
1.000   

04020760 4B   Cardoon                            4.000000   1.000     
1.000   

01010780 1AB  Carrot                             0.050000   1.000     
1.000   

01010781 1AB  Carrot-babyfood                    0.050000   1.000     
1.000   

01010790 1AB  Carrot, juice                      0.050000   1.000     
1.000   

09010800 9A   Casaba                             0.200000   1.000     
1.000   

14000810 14   Cashew                             0.010000   1.000     
1.000   

05010830 5A   Cauliflower                        0.980000   1.000     
1.000   

01010840 1AB  Celeriac                           0.050000   1.000     
1.000   

04020850 4B   Celery                             4.000000   1.000     
1.000   

04020851 4B   Celery-babyfood                    4.000000   1.000     
1.000   

04020860 4B   Celery, juice                      4.000000   1.000     
1.000   

04020870 4B   Celtuce                            4.000000   1.000     
1.000   

09020880 9B   Chayote, fruit                     0.200000   1.000     
1.000   

95000890 O    Cherimoya                          0.110000   1.000     
1.000   

12000900 12   Cherry                             0.210000   1.000     
1.000   

12000901 12   Cherry-babyfood                    0.210000   1.000     
1.000   

12000910 12   Cherry, juice                      0.210000   1.500     
1.000   

12000911 12   Cherry, juice-babyfood             0.210000   1.500     
1.000   

14000920 14   Chestnut                           0.010000   1.000     
1.000   

06030980 6C   Chickpea, seed                     0.010000   1.000     
1.000   

06030981 6C   Chickpea, seed-babyfood            0.010000   1.000     
1.000   

06030990 6C   Chickpea, flour                    0.010000   1.000     
1.000   

01011000 1AB  Chicory, roots                     0.050000   1.000     
1.000   

09021020 9B   Chinese waxgourd                   0.200000   1.000     
1.000   

04011040 4A   Chrysanthemum, garland             4.000000   1.000     
1.000   

10001060 10   Citrus citron                      0.100000   1.000     
1.000   

10001070 10   Citrus hybrids                     0.100000   1.000     
1.000   

10001080 10   Citrus, oil                        0.100000   0.600     
1.000   

95001150 O    Coffee, roasted bean               0.050000   1.000     
1.000   

95001160 O    Coffee, instant                    0.050000   1.000     
1.000   

05021170 5B   Collards                           0.820000   1.000     
1.000   

15001200 15   Corn, field, flour                 0.020000   1.000     
1.000   

15001201 15   Corn, field, flour-babyfood        0.020000   1.000     
1.000   

15001210 15   Corn, field, meal                  0.020000   1.000     
1.000   

15001211 15   Corn, field, meal-babyfood         0.020000   1.000     
1.000   

15001220 15   Corn, field, bran                  0.020000   1.000     
1.000   

15001230 15   Corn, field, starch                0.020000   1.000     
1.000   

15001231 15   Corn, field, starch-babyfood       0.020000   1.000     
1.000   

15001240 15   Corn, field, syrup                 0.020000   1.500     
1.000   

15001241 15   Corn, field, syrup-babyfood        0.020000   1.500     
1.000   

15001250 15   Corn, field, oil                   0.020000   1.000     
1.000   

15001251 15   Corn, field, oil-babyfood          0.020000   1.000     
1.000   

15001260 15   Corn, pop                          0.020000   1.000     
1.000   

15001270 15   Corn, sweet                        0.020000   1.000     
1.000   

15001271 15   Corn, sweet-babyfood               0.020000   1.000     
1.000   

95001280 O    Cottonseed, oil                    0.100000   1.000     
1.000   

95001281 O    Cottonseed, oil-babyfood           0.100000   1.000     
1.000   

11001290 11   Crabapple                          0.060000   1.000     
1.000   

95001300 O    Cranberry                          0.020000   1.000     
1.000   

95001301 O    Cranberry-babyfood                 0.020000   1.000     
1.000   

95001310 O    Cranberry, dried                   0.020000   1.000     
1.000   

95001320 O    Cranberry, juice                   0.020000   1.100     
1.000   

95001321 O    Cranberry, juice-babyfood          0.020000   1.100     
1.000   

04011330 4A   Cress, garden                      4.000000   1.000     
1.000   

04011340 4A   Cress, upland                      4.000000   1.000     
1.000   

09021350 9B   Cucumber                           0.200000   1.000     
1.000   

13021360 13B  Currant                            0.200000   1.000     
1.000   

13021370 13B  Currant, dried                     0.200000   1.000     
1.000   

04011380 4A   Dandelion, leaves                  4.000000   1.000     
1.000   

13011420 13A  Dewberry                           0.120000   1.000     
1.000   

08001480 8    Eggplant                           0.080000   1.000     
1.000   D28170

  Full comment: D281702, tomato

13021490 13B  Elderberry                         0.200000   1.000     
1.000   

04011500 4A   Endive                             4.000000   1.000     
1.000   

04021520 4B   Fennel, Florence                   4.000000   1.000     
1.000   

14001550 14   Filbert                            0.010000   1.000     
1.000   

14001560 14   Filbert, oil                       0.010000   1.000     
1.000   

20001630 20   Flaxseed, oil                      0.020000   1.000     
1.000   Tol.

01011680 1AB  Ginseng, dried                     0.050000   1.000     
1.000   

23001690 M    Goat, meat                         0.020000   1.000     
1.000   

23001700 M    Goat, meat byproducts              0.040000   1.000     
1.000   Rec. T

  Full comment: Rec. Tol.

23001720 M    Goat, kidney                       0.040000   1.000     
1.000   

23001730 M    Goat, liver                        0.040000   1.000     
1.000   

13021740 13B  Gooseberry                         0.200000   1.000     
1.000   

95001750 O    Grape                              0.060000   1.000     
1.000   D28170

  Full comment: D281702

95001760 O    Grape, juice                       0.060000   1.100     
1.000   

95001761 O    Grape, juice-babyfood              0.060000   1.100     
1.000   

95001770 O    Grape, leaves                      0.200000   1.000     
1.000   

95001780 O    Grape, raisin                      0.060000   2.300     
1.000   D28170

  Full comment: D281702

95001790 O    Grape, wine and sherry             0.060000   1.000     
1.000   

10001800 10   Grapefruit                         0.070000   1.000     
1.000   

10001810 10   Grapefruit, juice                  0.070000   0.600     
1.000   

06031820 6C   Guar, seed                         0.010000   1.000     
1.000   

06031821 6C   Guar, seed-babyfood                0.010000   1.000     
1.000   

14001850 14   Hickory nut                        0.010000   1.000     
1.000   

09011870 9A   Honeydew melon                     0.200000   1.000     
1.000   

95001880 O    Hop                                0.100000   1.000     
1.000   

24001890 M    Horse, meat                        0.020000   1.000     
1.000   

01011900 1AB  Horseradish                        0.050000   1.000     
1.000   

13021910 13B  Huckleberry                        0.200000   1.000     
1.000   

05021940 5B   Kale                               0.820000   1.000     
1.000   

05011960 5A   Kohlrabi                           0.980000   1.000     
1.000   

10001990 10   Lemon                              0.090000   1.000     
1.000   

10002000 10   Lemon, juice                       0.090000   0.600     
1.000   

10002001 10   Lemon, juice-babyfood              0.090000   0.600     
1.000   

10002010 10   Lemon, peel                        0.090000   1.000     
1.000   

06032030 6C   Lentil, seed                       0.010000   1.000     
1.000   

04012040 4A   Lettuce, head                      4.000000   1.000     
1.000   

04012050 4A   Lettuce, leaf                      4.000000   1.000     
1.000   

10002060 10   Lime                               0.100000   1.000     
1.000   

10002070 10   Lime, juice                        0.100000   0.600     
1.000   

10002071 10   Lime, juice-babyfood               0.100000   0.600     
1.000   

13012080 13A  Loganberry                         0.120000   1.000     
1.000   

11002100 11   Loquat                             0.060000   1.000     
1.000   

14002130 14   Macadamia nut                      0.010000   1.000     
1.000   

95002150 O    Mango                              0.110000   1.000     
1.000   D35744

  Full comment: D357449, avacado

95002151 O    Mango-babyfood                     0.110000   1.000     
1.000   

95002160 O    Mango, dried                       0.110000   1.000     
1.000   

95002170 O    Mango, juice                       0.110000   1.000     
1.000   

95002171 O    Mango, juice-babyfood              0.110000   1.000     
1.000   

28002210 M    Meat, game                         0.020000   1.000     
1.000   

27002220 D    Milk, fat                          0.020000   1.000     
1.000   

27002221 D    Milk, fat - baby food/infant for   0.020000   1.000     
1.000   

27012230 D    Milk, nonfat solids                0.020000   1.000     
1.000   

27012231 D    Milk, nonfat solids-baby food/in   0.020000   1.000     
1.000   

27022240 D    Milk, water                        0.020000   1.000     
1.000   

27022241 D    Milk, water-babyfood/infant form   0.020000   1.000     
1.000   

27032251 D    Milk, sugar (lactose)-baby food/   0.020000   1.000     
1.000   

15002260 15   Millet, grain                      0.020000   1.000     
1.000   

05022290 5B   Mustard greens                     0.820000   1.000     
1.000   

12002300 12   Nectarine                          0.210000   1.000     
1.000   

15002310 15   Oat, bran                          0.020000   1.000     
1.000   

15002320 15   Oat, flour                         0.020000   1.000     
1.000   

15002321 15   Oat, flour-babyfood                0.020000   1.000     
1.000   

15002330 15   Oat, groats/rolled oats            0.020000   1.000     
1.000   

15002331 15   Oat, groats/rolled oats-babyfood   0.020000   1.000     
1.000   

08002340 8    Okra                               0.080000   1.000     
1.000   

03002370 3    Onion, dry bulb                    0.030000   1.000     
1.000   

03002371 3    Onion, dry bulb-babyfood           0.030000   1.000     
1.000   

03002380 3    Onion, dry bulb, dried             0.030000   9.000     
1.000   

03002381 3    Onion, dry bulb, dried-babyfood    0.030000   9.000     
1.000   

10002400 10   Orange                             0.100000   1.000     
1.000   

10002410 10   Orange, juice                      0.100000   0.600     
1.000   

10002411 10   Orange, juice-babyfood             0.100000   0.600     
1.000   

10002420 10   Orange, peel                       0.100000   1.000     
1.000   

95002450 O    Papaya                             0.110000   1.000     
1.000   

95002451 O    Papaya-babyfood                    0.110000   1.000     
1.000   

95002460 O    Papaya, dried                      0.110000   1.800     
1.000   

95002470 O    Papaya, juice                      0.110000   1.500     
1.000   

04012480 4A   Parsley, leaves                    4.000000   1.000     
1.000   

01012500 1AB  Parsley, turnip rooted             0.050000   1.000     
1.000   

01012510 1AB  Parsnip                            0.050000   1.000     
1.000   

01012511 1AB  Parsnip-babyfood                   0.050000   1.000     
1.000   

06022550 6B   Pea, succulent                     0.010000   1.000     
1.000   

06022551 6B   Pea, succulent-babyfood            0.010000   1.000     
1.000   

06032560 6C   Pea, dry                           0.010000   1.000     
1.000   

06032561 6C   Pea, dry-babyfood                  0.010000   1.000     
1.000   

06012570 6A   Pea, edible podded, succulent      0.010000   1.000     
1.000   

06032580 6C   Pea, pigeon, seed                  0.010000   1.000     
1.000   

06022590 6B   Pea, pigeon, succulent             0.010000   1.000     
1.000   

12002600 12   Peach                              0.070000   1.000     
1.000   

12002601 12   Peach-babyfood                     0.070000   1.000     
1.000   

12002610 12   Peach, dried                       0.070000   7.000     
1.000   

12002611 12   Peach, dried-babyfood              0.070000   7.000     
1.000   

12002620 12   Peach, juice                       0.070000   1.000     
1.000   

12002621 12   Peach, juice-babyfood              0.070000   1.000     
1.000   

11002660 11   Pear                               0.060000   1.000     
1.000   

11002661 11   Pear-babyfood                      0.060000   1.000     
1.000   

11002670 11   Pear, dried                        0.060000   6.250     
1.000   

11002680 11   Pear, juice                        0.060000   0.750     
1.000   

11002681 11   Pear, juice-babyfood               0.060000   0.750     
1.000   

14002690 14   Pecan                              0.010000   1.000     
1.000   

08002700 8    Pepper, bell                       0.080000   1.000     
1.000   D28170

  Full comment: D281702, pepper 

08002701 8    Pepper, bell-babyfood              0.080000   1.000     
1.000   

08002710 8    Pepper, bell, dried                0.080000   1.000     
1.000   

08002711 8    Pepper, bell, dried-babyfood       0.080000   1.000     
1.000   

08002720 8    Pepper, nonbell                    0.080000   1.000     
1.000   

08002721 8    Pepper, nonbell-babyfood           0.080000   1.000     
1.000   

08002730 8    Pepper, nonbell, dried             0.080000   1.000     
1.000   

95002750 O    Peppermint                         1.500000   1.000     
1.000   

95002760 O    Peppermint, oil                    1.500000   0.050     
1.000   

14002820 14   Pistachio                          0.010000   1.000     
1.000   

12002850 12   Plum                               0.071000   1.000     
1.000   

12002851 12   Plum-babyfood                      0.071000   1.000     
1.000   

12002860 12   Plum, prune, fresh                 0.071000   1.000     
1.000   

12002861 12   Plum, prune, fresh-babyfood        0.071000   1.000     
1.000   

12002870 12   Plum, prune, dried                 0.071000   5.000     
1.000   

12002871 12   Plum, prune, dried-babyfood        0.071000   5.000     
1.000   

12002880 12   Plum, prune, juice                 0.071000   1.400     
1.000   

12002881 12   Plum, prune, juice-babyfood        0.071000   1.400     
1.000   

25002900 M    Pork, meat                         0.020000   1.000     
1.000   

25002901 M    Pork, meat-babyfood                0.020000   1.000     
1.000   

25002920 M    Pork, meat byproducts              0.020000   1.000     
1.000   

25002921 M    Pork, meat byproducts-babyfood     0.020000   1.000     
1.000   

25002940 M    Pork, kidney                       0.020000   1.000     
1.000   

25002950 M    Pork, liver                        0.020000   1.000     
1.000   

01032960 1C   Potato, chips                      0.250000   1.200     
1.000   

01032970 1C   Potato, dry (granules/ flakes)     0.250000   1.700     
1.000   

01032971 1C   Potato, dry (granules/ flakes)-b   0.250000   1.700     
1.000   

01032980 1C   Potato, flour                      0.250000   1.700     
1.000   

01032981 1C   Potato, flour-babyfood             0.250000   1.700     
1.000   

01032990 1C   Potato, tuber, w/peel              0.250000   1.000     
1.000   

01032991 1C   Potato, tuber, w/peel-babyfood     0.250000   1.000     
1.000   

01033000 1C   Potato, tuber, w/o peel            0.250000   1.000     
1.000   

01033001 1C   Potato, tuber, w/o peel-babyfood   0.250000   1.000     
1.000   

10003070 10   Pummelo                            0.100000   1.000     
1.000   

09023080 9B   Pumpkin                            0.200000   1.000     
1.000   

09023090 9B   Pumpkin, seed                      0.200000   1.000     
1.000   

11003100 11   Quince                             0.060000   1.000     
1.000   

29003120 M    Rabbit, meat                       0.020000   1.000     
1.000   

04013130 4A   Radicchio                          4.000000   1.000     
1.000   

01013140 1AB  Radish, roots                      0.050000   1.000     
1.000   

01013160 1AB  Radish, Oriental, roots            0.050000   1.000     
1.000   

05023180 5B   Rape greens                        0.820000   1.000     
1.000   

20003190 20   Rapeseed, oil                      0.020000   1.000     
1.000   

20003191 20   Rapeseed, oil-babyfood             0.020000   1.000     
1.000   

13013200 13A  Raspberry                          0.120000   1.000     
1.000   

13013201 13A  Raspberry-babyfood                 0.120000   1.000     
1.000   

13013210 13A  Raspberry, juice                   0.120000   1.000     
1.000   

13013211 13A  Raspberry, juice-babyfood          0.120000   1.000     
1.000   

04023220 4B   Rhubarb                            4.000000   1.000     
1.000   

15003230 15   Rice, white                        0.010000   1.000     
1.000   

15003231 15   Rice, white-babyfood               0.010000   1.000     
1.000   

15003240 15   Rice, brown                        0.010000   1.000     
1.000   

15003241 15   Rice, brown-babyfood               0.010000   1.000     
1.000   

15003250 15   Rice, flour                        0.010000   1.000     
1.000   

15003251 15   Rice, flour-babyfood               0.010000   1.000     
1.000   

15003260 15   Rice, bran                         0.010000   0.900     
1.000   

15003261 15   Rice, bran-babyfood                0.010000   0.900     
1.000   

01013270 1AB  Rutabaga                           0.050000   1.000     
1.000   

15003280 15   Rye, grain                         0.020000   1.000     
1.000   

15003290 15   Rye, flour                         0.020000   1.000     
1.000   

20003300 20   Safflower, oil                     0.020000   1.000     
1.000   

20003301 20   Safflower, oil-babyfood            0.020000   1.000     
1.000   

01013310 1AB  Salsify, roots                     0.050000   1.000     
1.000   

95003330 O    Sapote, Mamey                      0.400000   1.000     
1.000   

26003390 M    Sheep, meat                        0.020000   1.000     
1.000   

26003391 M    Sheep, meat-babyfood               0.020000   1.000     
1.000   

26003400 M    Sheep, meat byproducts             0.040000   1.000     
1.000   

26003420 M    Sheep, kidney                      0.040000   1.000     
1.000   

26003430 M    Sheep, liver                       0.040000   1.000     
1.000   

15003440 15   Sorghum, grain                     0.020000   1.000     
1.000   

15003450 15   Sorghum, syrup                     0.020000   1.000     
1.000   

06003470 6    Soybean, seed                      0.010000   1.000     
1.000   D28170

  Full comment: D281702

06003480 6    Soybean, flour                     0.010000   1.000     
1.000   

06003481 6    Soybean, flour-babyfood            0.010000   1.000     
1.000   

06003490 6    Soybean, soy milk                  0.010000   1.000     
1.000   

06003491 6    Soybean, soy milk-babyfood or in   0.010000   1.000     
1.000   

06003500 6    Soybean, oil                       0.010000   1.000     
1.000   

06003501 6    Soybean, oil-babyfood              0.010000   1.000     
1.000   

95003520 O    Spearmint                          1.500000   1.000     
1.000   

95003530 O    Spearmint, oil                     1.500000   0.050     
1.000   D28170

  Full comment: D281702

04013550 4A   Spinach                            4.000000   1.000     
1.000   

04013551 4A   Spinach-babyfood                   4.000000   1.000     
1.000   

09023560 9B   Squash, summer                     0.200000   1.000     
1.000   

09023561 9B   Squash, summer-babyfood            0.200000   1.000     
1.000   

09023570 9B   Squash, winter                     0.200000   1.000     
1.000   

09023571 9B   Squash, winter-babyfood            0.200000   1.000     
1.000   

95003590 O    Strawberry                         0.300000   1.000     
1.000   

95003591 O    Strawberry-babyfood                0.300000   1.000     
1.000   

95003600 O    Strawberry, juice                  0.300000   1.000     
1.000   

95003601 O    Strawberry, juice-babyfood         0.300000   1.000     
1.000   

20003640 20   Sunflower, seed                    0.020000   1.000     
1.000   

20003650 20   Sunflower, oil                     0.020000   1.000     
1.000   

20003651 20   Sunflower, oil-babyfood            0.020000   1.000     
1.000   

01033660 1CD  Sweet potato                       0.020000   1.000     
1.000   

01033661 1CD  Sweet potato-babyfood              0.020000   1.000     
1.000   

04023670 4B   Swiss chard                        4.000000   1.000     
1.000   

10003690 10   Tangerine                          0.100000   1.000     
1.000   

10003700 10   Tangerine, juice                   0.100000   0.600     
1.000   

01033710 1CD  Tanier, corm                       0.020000   1.000     
1.000   

08003740 8    Tomatillo                          0.080000   1.000     
1.000   

08003750 8    Tomato                             0.080000   1.000     
1.000   

08003751 8    Tomato-babyfood                    0.080000   1.000     
1.000   

08003760 8    Tomato, paste                      0.080000   3.800     
1.000   D26507

  Full comment: D265079

08003761 8    Tomato, paste-babyfood             0.080000   3.800     
1.000   

08003770 8    Tomato, puree                      0.080000   1.700     
1.000   D26507

  Full comment: D265079

08003771 8    Tomato, puree-babyfood             0.080000   1.700     
1.000   

08003780 8    Tomato, dried                      0.080000  14.300     
1.000   

08003781 8    Tomato, dried-babyfood             0.080000  14.300     
1.000   

08003790 8    Tomato, juice                      0.080000   1.500     
1.000   

15003810 15   Triticale, flour                   0.020000   1.000     
1.000   

15003811 15   Triticale, flour-babyfood          0.020000   1.000     
1.000   

01033870 1CD  Turmeric                           0.250000   1.000     
1.000   

01013880 1AB  Turnip, roots                      0.050000   1.000     
1.000   

05023890 5B   Turnip, greens                     0.820000   1.000     
1.000   

14003910 14   Walnut                             0.010000   1.000     
1.000   

86010000 O    Water, direct, all sources         0.011310   1.000     
1.000   

86020000 O    Water, indirect, all sources       0.011310   1.000     
1.000   

09013990 9A   Watermelon                         0.200000   1.000     
1.000   

09014000 9A   Watermelon, juice                  0.200000   1.000     
1.000   

15004010 15   Wheat, grain                       0.020000   1.000     
1.000   

15004011 15   Wheat, grain-babyfood              0.020000   1.000     
1.000   

15004020 15   Wheat, flour                       0.020000   1.000     
1.000   

15004021 15   Wheat, flour-babyfood              0.020000   1.000     
1.000   

15004030 15   Wheat, germ                        0.020000   1.000     
1.000   

15004040 15   Wheat, bran                        0.020000   1.000     
1.000   

15004050 15   Wild rice                          0.020000   1.000     
1.000   

01034060 1CD  Yam, true                          0.250000   1.000     
1.000   

01034070 1CD  Yam bean                           0.250000   1.000     
1.000   

 

Attachment 3.  Summary of the acute dietary exposure analysis for
thiamethoxam.

U.S. Environmental Protection Agency                                 
Ver. 2.02

DEEM-FCID ACUTE Analysis for THIAMETHOXAM                       
(1994-98 data)

Residue file: 060109 2010 Acute T+Water.R98       Adjustment factor #2
NOT used.

Analysis Date: 03-04-2010/14:42:21    Residue file dated:
03-04-2010/14:31:37/8

Daily totals for food and foodform consumption used.

Run Comment: "Acute and Chronic RfDs = aPAD and cPAD"

========================================================================
=======

Summary calculations (per capita):

                    95th Percentile      99th Percentile      99.9th
Percentile

                   Exposure   % aRfD    Exposure   % aRfD    Exposure  
% aRfD 

                  ---------- --------  ---------- --------  ----------
--------

U.S. Population:

                    0.018088     5.17    0.029783     8.51    0.058399  
 16.69 

All infants:

                    0.033163     9.48    0.053495    15.28    0.087403  
 24.97 

Children 1-2 yrs:

                    0.032980     9.42    0.056583    16.17    0.108262  
 30.93 

Children 3-5 yrs:

                    0.026607     7.60    0.046287    13.22    0.078998  
 22.57 

Children 6-12 yrs:

                    0.018827     5.38    0.034687     9.91    0.070883  
 20.25 

Youth 13-19 yrs:

                    0.014308     4.09    0.022198     6.34    0.038728  
 11.07 

Adults 20-49 yrs:

                    0.016273     4.65    0.025229     7.21    0.042138  
 12.04 

Adults 50+ yrs:

                    0.016610     4.75    0.025537     7.30    0.040483  
 11.57 

Females 13-49 yrs:

                    0.016146     4.61    0.025614     7.32    0.046369  
 13.25 

Attachment 4.  Summary of the chronic dietary exposure analysis for
thiamethoxam.

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for THIAMETHOXAM                     (1994-98
data)

Residue file name: C:\Documents and Settings\dmcneill\My
Documents\Thiamethoxam\060109 2010 T+Water.R98

                                                 Adjustment factor #2
NOT used.

Analysis Date 03-04-2010/14:34:29     Residue file dated:
03-04-2010/14:33:35/8

Reference dose (RfD, Chronic) = .012 mg/kg bw/day

COMMENT 1: Acute and Chronic RfDs = aPAD and cPAD

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg             Percent
of   

           Subgroup                       body wt/day             Rfd   
   

--------------------------------------   -------------      
---------------

U.S. Population (total)                     0.002795               
23.3%

U.S. Population (spring season)             0.002864               
23.9%

U.S. Population (summer season)             0.002784               
23.2%

U.S. Population (autumn season)             0.002755               
23.0%

U.S. Population (winter season)             0.002778               
23.1%

Northeast region                            0.002900               
24.2%

Midwest region                              0.002814               
23.4%

Southern region                             0.002515               
21.0%

Western region                              0.003123               
26.0%

Hispanics                                   0.002879               
24.0%

Non-hispanic whites                         0.002797               
23.3%

Non-hispanic blacks                         0.002415               
20.1%

Non-hisp/non-white/non-black                0.003638               
30.3%

All infants (< 1 year)                      0.003002               
25.0%

Nursing infants                             0.001314               
10.9%

Non-nursing infants                         0.003643               
30.4%

Children 1-6  yrs                           0.004543               
37.9%

Children 7-12 yrs                           0.003090               
25.7%

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 20.4%

Females 13+ (nursing)                       0.003097               
25.8%

Males 13-19 yrs                             0.002370               
19.7%

Males 20+ yrs                               0.002469               
20.6%

Seniors 55+                                 0.002601               
21.7%

Children 1-2 yrs                            0.005065               
42.2%

Children 3-5 yrs                            0.004446               
37.1%

Children 6-12 yrs                           0.003196               
26.6%

Youth 13-19 yrs                             0.002308               
19.2%

Adults 20-49 yrs                            0.002567               
21.4%

Adults 50+ yrs                              0.002625               
21.9%

Females 13-49 yrs                           0.002595               
21.6%

------------------------------------------------------------------------
-------

Thiamethoxam (060109) 	        Dietary Exposure and Risk Assessment	    
     	   DP Numbers D373595/D375247 

 PAGE   

Page   PAGE  25  of   NUMPAGES  26 

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