UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, DC 20460

			OFFICE OF  PREVENTION, PESTICIDES,  AND TOXIC SUBSTANCES

 

Memorandum									01/09/08

Subject:	Amended Product Chemistry of Benzene,
1-((diiodomethyl)sulfonyl)-4-methyl or Diiodomethyl p-tolyl sulfone for
the Reregistration Eligibility Decision (RED). DP 348167

From:		A. Najm Shamim, Ph.D., Chemist

		Regulatory Management Branch II

		Antimicrobials Division (7510P)

To:		Bill Hazel, Risk Assessor for Diiodomethyl p-tolyl sulfone RED

		Risk Assessment and Science Support Branch 

		Antimicrobials Division (7510P)

		

		Jonathan Chen, Ph.D., Toxicologist for Diiodomethyl p-tolyl sulfone
RED

		Risk Assessment and Science Support Branch 

		Antimicrobials Division (7510P)

				And

		Kathryn Jakob,

		CRM for Diiodomethyl p-tolyl sulfone RED

		Regulatory Management Branch II

		Antimicrobials Division (7510P)

Thru:		Mark Hartman Chief

		Regulatory Management Branch II

		Antimicrobials Division (7510P)

PRODUCT CHEMISTRY OF DIIODOMETHYL P-TOYL SULFONE

CAS#:			20018-09-1

Chemical Name:	Benzene, 1-((diiodomethyl)sulfonyl)-4-methyl

Common Name: 	Diiodomethyl p-tolyl sulfone / Amical 48

Chemical Formula:	C8H8 I2 O2S

Mol. Wt:		422.01

Molecular Structure:

 

Physical and Chemical Characteristics of Diiodomethyl p-tolyl sulfone

Color:			Tan4

Physical State:		Powder at room temeprature4

Odor:			Not tested4

MP:			136 o C 3  / 149-152 oC 4				

BP:			394 o C 3   

Specific Gravity:	  	~ 1  at 25 o  C1

Vapor Pressure:		1.87 x 10-6  mm Hg 3  / 5.2 x 10-8  mm Hg at 25 o C4

Solubility:			10 mg/L 2   at 25 o C 4   in water 

Henry Law Constant:	 6.03x 10-7  atm-m3 /mole3

Persistence in Air:		 23.4 Hours3

Dissociation Constant:	 No data available

Log KOW :			 2.66 2 

pH:			 4.3 4  

Stability:			Stable at room temperature4  and stable at 54±2 o  C4 			
for two weeks 

Redox Potentials: 		Not oxidizing4

Flammability:		60 o C 1

Explodability:		Does not contain explosive material1

Viscosity:		            60 mPa.s at 25 o C1

Miscibility:		 Not determined1

Corrosion Characteristics: No data available1

Dielectric Breakdown Voltage: Not to be used around electrical
equipment1

Log KOC :			2.7883 

UV-visible spectra: 	Two absorption peaks: 200 and 233-234 nm; the 

spectra were run from 200-800 nm range5

24. Storage Stability:	Amical 48 is stable for 8 years at ambient
temperature, 

stable for 36 months at 30o C and for 6 months at 40 o C. See the
comments below6BIBLIOGRAPHY

MRID#:			REFERENCES

457574-02	Alan Ross, 2002: Product Chemistry Data for BAZOOKA  Sapstian
and Mold Control Product; Performing Lab: Kop-Coat, Inc, MO 63110

421772-02	Octanol/Water Partition Coefficient of Amical™ 48, 1991, by
Willard Laster; Performing Lab: ABC Laboratories, Inc., MO: 65205

472340-04	Physical-Chemical Determination for BPD dossier on Amical 48
Antimicrobial by J. Sudworth, 2007; Performing Labs: Intertek ASG,
Blackely, Manchester, England: M9 8ZS.  The data were generated based on
OECD Guidelines; Study #: 1305291

472340-03			Determination of UV-Visible  Absorption  Characteristics 

of Amical 48 Antifungal Agent by Andrea Lopez, 2007; 

Performing Labs: PTRL West, Inc. Hercules, CA: 94547; 

Data were generated by OECD guidelines 101 Lab Study 

ID#: PTRL 1654W

EPISUITE, Version 3.2

Dow Chemical Company in November 2007 provided the following comments
and information regarding the storage stability of Diiodomethyl p-tolyl
sulfone.

Registrants over a period of time (1982 through 1994) had asked various
Laboratories to conduct a variety of stability studies (storage
stability included).

™ 48 and Amical 50 were stored on laboratory shelf for eight years and
an HPLC analysis after eight years showed no significant breakdown for
Amical™ 48 or Amical 50.”

Abbott Laboratories in 1982 reported: “Amical™ 48 was added to
acidic water (no pH value is mentioned) and a titration method showed
that Amical 48 is stable for 16 hours at 40 o C. Amical™ 48 is used
for leather processing at 40 o C and acidic conditions in water. The
acidity in water was generated by adding dilute sulfuric acid and dilute
formic acid (Lab Project #: 35-208-62)

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8en minutes.”

Abbott Laboratories in 1988 reported: “ Amical™ 48 and other Amical
products were stable for 36 months at 30 o C  and  stable for 6 months
at 40 o C. the analysis was conducted by HPLC technique

The references for these studies are as follows:

MRID #		REFERENCES

42054401		Quinn, L, 1991: AMICAL 48, Product Chemistry. 

Originally submitted by Angus Chemicals

NO MRID #  	Sinning, D, 2003:  Physical Chemcial Characteristics of  

AMICAL 48: Melting Point, Boiling Point, Water 

Solubility and
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NO MRID #	Little, K, 2007: AMICAL™ 48: Summary of Storage 

Stabilities; submitted by: The Dow Chemical Companies.

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