ATTACHMENT III:  The unsigned DRAFT HED document entitled, “Revised
Postapplication Exposure and Risk for Episodic Ingestion of the Bonide
Dog & Rabbit Chaser End-Use Product (EPA Reg. No. 4-465)”.  1 p. 
[Note:  This document was drafted (08/29/2007) in response to
recommendations specified in the HED Risk Assessment Review Committee
(RARC2) Report dated August 22, 2007.]



Revised Postapplication Exposure and Risk for Episodic Ingestion of the
Bonide Dog & Rabbit Chaser End-Use Product (EPA Reg. No. 4-465)

Because of the way that F&B rabbit and dog chaser is applied in
residential areas, i.e., in inch-wide bands around lawns, ornamentals
and vegetable gardens, there is the potential for young children to pick
up a handful of the applied product and ingest it.  The acute oral LD50
in the rat is >5,050 mg/kg (MRID 43523301).  At this dose none of the
rats in the study died, but treated rats exhibited a number of symptoms
including decreased activity, diarrhea, crust around the eyes and nose,
piloerection, polyuria, ptosis, respiratory gurgle and salivation.  If a
child weighing 10 kg were to ingest 2 teaspoonfuls of the product (about
5-6 grams), the corresponding dose would be approximately 500 mg/kg or
one-tenth of the dose that caused moderate toxicity in rats.  Since, as
discussed elsewhere in this risk assessment, humans appear to be more
sensitive than rats, perhaps by an order of magnitude, and ingestion of
1-2 teaspoons of product by a child is not considered excessive, HED is
concerned about the potential for accidental ingestion of the applied
product.

DRAFT

Page   PAGE  1  of 1

