UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

OFFICE OF PREVENTION, PESTICIDES

AND TOXIC SUBSTANCES

MEMORANDUM

September 30, 2007

SUBJECT:	Busan 77 – Incident Report Summary

PC Code: 	069183

FROM:	Jonathan Chen, Ph.D.	

	Toxicologist

	Risk Assessment and Science Support Branch (RASSB)

Antimicrobial Division (7510C)

THROUGH:	Norm Cook

Chief

RASSB / AD

TO:		ShaRon Carlisle, Chemical Review Manager

		Regulatory Management Branch II

		Antimicrobials Division (7510P)     

Attached is RASSB’s incident reports summary associated with Busan 77.



INCIDENT REPORTS ASSOCIATED WITH

Busan 77

 (PC CODE: 069183)

August 3, 2007

U.S. Environmental Protection Agency

Office of Pesticide Programs

Antimicrobials Division

TABLE OF CONTENTS

  TOC \o "1-3" \h \z \u    HYPERLINK \l "_Toc174154284"  0.0
INTRODUCTION	  PAGEREF _Toc174154284 \h  1  

  HYPERLINK \l "_Toc174154285"  1.0 	INCIDENT REPORT DATA ASSOCIATED
WITH HEALTH EFFECTS	  PAGEREF _Toc174154285 \h  1  

  HYPERLINK \l "_Toc174154286"  1.1	OPP’s Incident Data System (IDS)	 
PAGEREF _Toc174154286 \h  2  

  HYPERLINK \l "_Toc174154287"  1.2	Poison Control Center (1993 –
1998)	  PAGEREF _Toc174154287 \h  2  

  HYPERLINK \l "_Toc174154288"  1.4	National Pesticide
Telecommunications Network (NPTN)	  PAGEREF _Toc174154288 \h  3  

  HYPERLINK \l "_Toc174154289"  1.5	Incident Reports / Epidemiological
Studies Published in Scientific Literature	  PAGEREF _Toc174154289 \h  3
 

  HYPERLINK \l "_Toc174154290"  2.0 	CONCLUSION	  PAGEREF _Toc174154290
\h  3  

 

0.0	INTRODUCTION tc \l1 "0.0	INTRODUCTION 

The purpose of this chapter is to review the evidence of health effects
in humans resulting from exposure to Busan77.  

Two approaches are used in this section:

The potential health effects of Busan77 in humans, reported as incident
reports from different sources, are summarized. 

A literature search of chronic health effects associated with Busan77
exposure, including results of epidemiological studies, is summarized.

1.0 	INCIDENT REPORT DATA ASSOCIATED WITH HEALTH EFFECTS 

The following databases have been consulted for incident data:

OPP Incident Data System (IDS) - The Incident Data System of The Office
of Pesticide Programs (OPP) of the Environmental Protection Agency (EPA)
contains reports of incidents from various sources, including
registrants, other federal and state health and environmental agencies
and individual consumers, submitted to OPP since 1992.  Reports
submitted to the Incident Data System represent anecdotal reports or
allegations only, unless otherwise stated.  Typically no conclusions can
be drawn implicating the pesticide as a cause of any of the reported
health effects.  Nevertheless, sometimes with enough cases and/or enough
documentation risk mitigation measures may be suggested.

Poison Control Centers - as the result of a data purchase by EPA, OPP
received Poison Control Center data covering the years 1993 through 1998
for all pesticides.  Most of the national Poison Control Centers (PCCs)
participate in a national data collection system, the Toxic Exposure
Surveillance System, which obtains data from about 65-70 centers at
hospitals and universities.  PCCs provide telephone consultation for
individuals and health care providers on suspected poisonings involving
drugs, household products, pesticides, etc.

California Department of Pesticide Regulation - California has
collected uniform data on suspected pesticide poisonings since 1982. 
Physicians are required, by statute, to report to their local health
officer all occurrences of illness suspected of being related to
exposure to pesticides.  The majority of the incidents involve workers. 
Information on exposure (worker activity), type of illness (systemic,
eye, skin, eye/skin and respiratory), likelihood of a causal
relationship, and number of days off work and in the hospital are
provided.

National Pesticide Telecommunications Network (NPTN) - NPTN is a
toll-free information service supported by OPP.  A ranking of the top
200 active ingredients for which telephone calls were received during
calendar years 1984-1991, inclusive, has been prepared.  The total
number of calls was tabulated for the categories of human incidents,
animal incidents, calls for information, and others.

1.1	OPP’s Incident Data System (IDS) tc \l2 "1.1 	OPPs Incident Data
System (IDS) 

There are 34 human incidences that have been reported in the OPP
incident data system are associated with Busan77 exposure.  The symptoms
associated with these incidences are classified as minor or moderate.
There is no severe symptoms been reported associated with Busan 77
exposure.  The most common symptoms reported for cases of dermal
exposure were skin irritation/burning, rash, itching and skin
discoloration/redness.  The most common symptoms reported for cases of
inhalation exposure were minor respiratory irritation/burning. In some
case, headache is reported after inhalation exposure.  The symptoms
associated ocular exposure including blurred vision, edema and
irritation around eyes.

1.2	Poison Control Center (1993 – 1998) tc \l2 "1.2 	 Poison Control
Center 

Besides the incidences been covered in the OPP IDS, there is no reported
Busan77 specific incident in the PCC’ s database.

1.3	California Data - 1982 through 2003

There is no incident Busan77 specific incident reported in the 

1.4	National Pesticide Telecommunications Network (NPTN) tc \l2 "1.4 
National Pesticide Telecommunications Network (NPTN) 

There is no incident reported in the NPTN database related to Busan 77
exposure.

1.5	Incident Reports / Epidemiological Studies Published in Scientific
Literature

There is no incident can be located related to Busan 77 exposure.

2.0 	CONCLUSION

Although limited incidents reported in OPP IDS show exposure to Busan 77
may have some irritation concern through dermal, inhalation, and/or
ocular exposure, most of the symptoms are consider minor.  There is no
severe incident been reported associated with Busan 77 exposure.  There
is no epidemiological study can be located associated with Busan77
exposure.

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