UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, DC 20460

			

 

									June 28, 2007

MEMORANDUM

Subject:	Product Chemistry Science Chapter for Copper-8 Quinolinate OR
Copper Oxine

From:		A. Najm Shamim, PhD., Chemist

		Regulatory Management Branch II

		Antimicrobials Division (7510P)

To:		Tim McMahon, PhD., Risk Assessor and Senior Toxicologist

		Antimicrobials Division (7510P)

				And

		Kathryn Jakob, CRM for Copper-8 Quinolinate

		Regulatory Management Branch II

		Antimicrobials Division (7510P)

Thru:		Diane Isbell, Team Leader,

		Regulatory Management Branch II

		Antimicrobials Division (7510P)

				And

		Mark Hartman, Chief

		Regulatory Management Branch II

		Antimicrobials Division (7510P)

Physical and Chemical Characteristics of Copper Oxine

Copper-8-Quinolate or Copper Oxine is prepared with 98% purity (TGAI).
It is a coordination compound or a 1: 2 complex between copper and
organic ligand 8-hydroxy quinoline. 

It is used as a fungicide, algaecide, and bactericide.  It is also
applied as a preservative on wood for antisapstain use.

Chemical Name:	Copper, bis (8-quinolinolato-N1,O8)-

Common Name: 	Copper 8-Quinolate/ Copper Oxine

Trade Names:		

Molecular Weight:	351.851

Molecular Formula:	C18H12 Cu N2O2

CAS#:			10380-28-6

State:			Crystalline Powder

Color:			Olive Green

Odor:			Odorless

MP:			 270 o C (decomposes below MP)

BP:			Not determined

Vapor Pressure:	Can not be calculated even at 270 o C*

Log Kow:		3.14

Solubility:		0.7 mg/L at 25 o C

Henry law Constant:	7.849 x 10—13 atm-m3/mole

Half Life in Air:	0.642 Hours (measured against OH radical reaction)

Log Koc:		6.69

Specific Gravity:	1.63

Chemical Structure:

  

* EPISuite Program estimated the vapor pressure of copper-8 as: 6.3 x
10-12 mm Hg

					BIBLIOGRAPHY

MRID#				REFERENCE

1. 435329-01		Product Chemistry of Copper-8-Quinoinolate, 1994, by Tomio
Katoh. Chemical Research Lab, Lab ID#: TOM-EPA-1

2. 429227-01C	Oxine Copper, 1990 by J. Freyre and G. Griffon. LA
Quinoleine S.A, Usine D’Oissel, France

3. 435630-01		Product Chemistry of Copper-8 Quinoinolate, 1994, by Tomil
Katoh. Chemical Research Lab. ID# TOM-EPA-1

4. 463464-01C and 46346-01: Product Identity and Composition of Q8 Log
Oil by Michael Kellog. 2004. Study #: 200401

5. 464386-01C and 464386-01: Product Chemistry Data on Osmose ORD-X378,
2004. By Teri Muchow. Study ID#:  OSMOSE-2004-6

6. 468352-01C and 468352-01: Product Chemistry Data,
Cooper-8-Hydroxyquinoline (COX), 2006 by Bruce Bernard, PhD. Lab: SRA
International. Sonsor ID#: COX 2006-2

7.  EPI Suite: 	US EPA’s Estimation Program of Physical/Chemical
Characteristics of Chemicals

