	UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

	WASHINGTON, D.C.  20460

	OFFICE OF PREVENTION,

	PESTICIDES AND TOXIC 

		SUBSTANCES

	

	April 23, 2007

	DP Barcode: D339258										PC Code: 036602

MEMORANDUM 

SUBJECT:	Drinking water assessment for mandipropamid and its two
degradates (SYN500003, SYN504851) use on brassica vegetables, bulb
vegetables, cucurbits, fruiting vegetables, grapes, leafy vegetables,
potatoes, tomatoes, tuberous and corm vegetables.

TO:		Dennis McNeilly, Chemist

		Registration Action Branch 2

		Health Effects Division (P7509)

	

FROM:	Ibrahim Abdel-Saheb, Ph.D., Environmental Scientist

Environmental Risk Branch II

Environmental Fate and Effects Division

THRU:	Dana Spatz, Senior Chemist

Environmental Risk Branch II

Environmental Fate and Effects Division

Tom Bailey, Ph.D., Branch Chief

Environmental Risk Branch II

Environmental Fate and Effects Division		

INTRODUCTION

	This memorandum transmits the Tier I Estimated Environmental
Concentrations (EECs) resulting from 4 applications of 0.13 lb ai/acre
of mandipropamid and its two degradates (SYN500003 and SYN504851). HED
requested to include these two degradates in this water assessment due
to their high amounts formed in laboratory studies (9.4 and 38% of the
applied radioactivity under aerobic aquatic conditions), and
toxicological concerns.

CONCLUSIONS

	A screening assessment of estimated environmental concentrations (EECs)
for mandipropamid and its major aquatic degradates (SYN500003 and
SYN504851) in drinking water was conducted.  Screening models were used
to determine estimated concentrations in ground water and surface water.
 A national PCA of 0.87 (default) was used in order to better reflect
the expected exposures from the proposed uses.

	Based on surface (FIRST 1.1.0) and ground water (SCI-GROW 2.3) modeling
, the surface and groundwater Expected Environmental Concentrations
(EEC) of mandipropamid  and its major degradates (SYN500003 and
SYN504851) are shown in table 1.

Table 1. Estimated drinking water concentrations to be used for exposure
to mandipropamid and its major degradates (SYN500003, SYN504851) in
drinking water derived from surface water and ground water.

	Model EEC Value (μg/L)

	Mandipropamid	SYN500003	SYN504851	Four applications @0.13 lbai/A with 7
days interval between applications	PCA %

Acute	25.2	2.323	8.993

0.87

Annual average (chronic)	1.00	0.381	5.858

0.87

Groundwater	5.22E-02	5.85E-01	1.73E	Four applications @0.13 lbai/A with
7 days interval between applications	None



BACKGROUND

Mandipropamid is a new pesticide (also known as Revus) is the active
ingredient in the fungicide

RevusTM, which is proposed for control of a certain diseases in brassica
vegetables, bulb vegetables,

cucurbits, fruiting vegetables, grapes, leafy vegetables, potatoes,
tomatoes, tuberous and corm

vegetables.

Groundwater and surface water monitoring data are not available to the
Environmental Fate and Effects Division (EFED) for mandipropamid or its
degradates (new chemical). Screening models were used to determine
drinking water EECs.

              

SURFACE WATER

Table 2. Selected Surface Water Exposure Inputs for FIRST 1.1.0 for
Mandipropamid.

MODEL INPUT VARIABLE	INPUT VALUE	COMMENTS

Application rate (lb ai/A)	0.13	EPA Reg. 100-RELU

Number of application	4	EPA Reg. 100-RELU

Interval between appl. (d)	7	EPA Reg. 100-RELU

Koc(mL/g)	405.1	MRID# 46800040-41; Lowest non-sand;  Input Parameters
Guidance, 2002

Aerobic Soil Metabolic Half-life (days)	81.3 (parent)	MRID#
46800020,21,22,24,25,27-28; Input Parameters Guidance, 2002

Wetted in?	No	EPA Reg. 100-RELU

Depth of Incorporation (cm)	0	EPA Reg. 100-RELU

Method of application	Aerial	EPA Reg. 100-RELU

Percent cropped area	0.87	PCA that gives the max. EECs used;  FIRST
users manual.

Solubility (mg/L)	2.3	MRID# 46800007, 46800008

Aerobic Aquatic Metabolic Half-life (days)	19.3	MRID# 46800033-34; 
Input Parameters Guidance, 2002

Hydrolysis (pH 7) half-life (days)	0	MRID# 46800007, 46800008

Aqt. Photolysis Half-life (days)	1.1	MRID# 46800014; maximum value.



Table 3. Selected Surface Water Exposure Inputs for FIRST 1.1.0 for
mandipropamid degradate, SYN 00003.

MODEL INPUT VARIABLE	INPUT VALUE	Data Source/ Comments

Application rate (lb ai/A)	0.007*	EPA Reg. 100-RELU

Number of application	4	EPA Reg. 100-RELU

Interval between appl. (d) 	7	EPA Reg. 100-RELU

Koc(mL/g)	2.89	MRID# 46800037; Lowest non-sand;  Input Parameters
Guidance, 2002

Aerobic Soil Metabolic Half-life (days)	81.3 (parent)	No data available
for degradate; MRID# 46800020,21,22,24,25,27-28; Input Parameters
Guidance, 2002

Wetted in?	No	EPA Reg. 100-RELU

Depth of Incorporation (cm)	0	EPA Reg. 100-RELU

Method of application	Ground	EPA Reg. 100-RELU

Percent cropped area	0.87	PCA that gives the max. EECs used;  FIRST
users manual.

Solubility (mg/L)	170000	Europena Federal Office for Food Safety;
Monograph prepared in the context of inclusion of following active
substance in Annex I of the Council Directive 91/414/EEC
(Mandipropamid), 2006.

Aerobic Aquatic Metabolic Half-life (days)	58.1	MRID# 46800029;  Input
Parameters Guidance, 2002

Hydrolysis (pH 7) half-life (days)	0 	No data available for
degradate;MRID# 46800007, 46800008

Aqt. Photolysis Half-life (days)	0	No data available for degradate;
Input Parameters Guidance, 2002

	*: Application rate was calculated by multiplying the parent appl.
rate X maximum percent of degradate formed (i.e. 	9.4% of applied
radioactivity; MRID# 46800031) X (degradate M.Wt/parent M.Wt).



Table4. Selected Surface Water Exposure Inputs for FIRST 1.1.0 for
mandipropamid degradate, SYN 504851. 

MODEL INPUT VARIABLE	INPUT VALUE	Data Source/ Comments

Application rate (lb ai/A)	0.027*	EPA Reg. 100-RELU

Number of application	4	EPA Reg. 100-RELU

Interval between appl. (d)	7	EPA Reg. 100-RELU

Koc(mL/g)	3	MRID# 46800044; Lowest non-sand;  Input Parameters Guidance,
2002

Aerobic Soil Metabolic Half-life (days)	81.3 (parent)	No data available
for degradate; MRID# 46800020,21,22,24,25,27-28; Input Parameters
Guidance, 2002

Wetted in?	No	EPA Reg. 100-RELU

Depth of Incorporation (cm)	0	EPA Reg. 100-RELU

Method of application	Ground	EPA Reg. 100-RELU

Percent cropped area	0.87	PCA that gives the max. EECs used;  FIRST
users manual.

Solubility (mg/L)	500000	Europena Federal Office for Food Safety;
Monograph prepared in the context of inclusion of following active
substance in Annex I of the Council Directive 91/414/EEC
(Mandipropamid), 2006.

Aerobic Aquatic Metabolic

Half-life (days)	1323 (441 X 3)	MRID# 46800029;  single half life
multiplied by 3; Input Parameters Guidance, 2002

Hydrolysis (pH 7) half-life (days)	0 	No data available for degradate;
MRID# 46800007, 46800008

Aqt. Photolysis Half-life (days)	0	No data available for degradate;
Input Parameters Guidance, 2002

	**: Application rate was calculated by multiplying the parent appl.
rate X maximum percent of degradate formed 	(i.e. 38% of applied
radioactivity; MRID# 46800031) X (degradate M.Wt/parent M.Wt).

GROUND WATER

The SCI-GROW model is based on scaled ground water concentration from
ground water monitoring studies, environmental fate properties (aerobic
soil half-lives and organic carbon partitioning coefficients-Koc 's) and
application rates. The model is based on permeable soils that are
vulnerable to leaching and on shallow ground water (10-30 feet).
SCI-GROW version 2.3 (executable file dated 08/05/2003) was used to
estimate concentrations of mandipropamid and its major degradate
(SYN500003, SYN504851) that could be found in drinking water derived
from ground water, using the input values listed in the table 3. 

Table 5. Ground Water Exposure Inputs for SCI-GROW for parent
mandipropamid and its two degradate  (SYN 00003, SYN 504851).

MODEL INPUT VARIABLE	INPUT VALUE	Data Source/ Comments

	Parent	SYN 00003	SYN 504851

	Application Rate (lbs. ai/A)	0.13	0.007*	0.027*	EPA Reg. 100-RELU

Maximum No. of Applications	4	4	4	EPA Reg. 100-RELU

Koc	782	2.92	5	Median non-sand. MRID 46800038-41 (parent); 46800037 (SYN
00003), 46800044 (SYN 504851);  Input parameter guidance, 2002. 

Aerobic Soil Metabolic Half-life(days)	75.1 (median)	81.3 (parent)	81.3
(parent)	No data available for degradate; MRID# 46800033-34; MRID#
46800029; Input parameter guidance, 2002.



*: Application rate was calculated by multiplying the parent appl. rates
X maximum percent of degradate formed X (degradate M.Wt/parent M.Wt).

Results from the SCI-GROW screening model predict that the maximum
chronic and acute concentration of parent mandipropamid and its major
degradate (SYN500003, SYN504851) in shallow ground water is not expected
to exceed 4.19E+01 µg/L for the current maximum seasonal use rate.



APPENDIX I

FIRST MODEL 1.1.0 INPUT & OUTPUT FILES

RUN No.   1 FOR Mandipropamid    ON   all           * INPUT VALUES * 

  
------------------------------------------------------------------------
--------------------------------

    RATE (#/AC)   No.APPS &   SOIL  SOLUBIL  APPL TYPE  %CROPPED INCORP

     ONE(MULT)    INTERVAL    Koc   (PPM )   (%DRIFT)     AREA    (IN)

  
------------------------------------------------------------------------
--------------------------------

   .130(   .477)         4       7           405.1    2.3         
AERIAL(16.0)  87.0    .0

   FIELD AND RESERVOIR HALFLIFE VALUES (DAYS) 

  
------------------------------------------------------------------------
-----------------------------------------

   METABOLIC  DAYS UNTIL  HYDROLYSIS   PHOTOLYSIS   METABOLIC  COMBINED

    (FIELD)  RAIN/RUNOFF  (RESERVOIR)  (RES.-EFF)   (RESER.)   (RESER.) 

  
------------------------------------------------------------------------
-------------------------------------------

     81.30        2          N/A      1.10-  136.40    19.30     16.91

   UNTREATED WATER CONC (MICROGRAMS/LITER (PPB)) Ver 1.1.0 DEC 12, 2005

  
------------------------------------------------------------------------
----------

        PEAK DAY  (ACUTE)      ANNUAL AVERAGE (CHRONIC)      

          CONCENTRATION             CONCENTRATION            

  
------------------------------------------------------------------------
----------

1.006

RUN No.   2 FOR  SYN00003         ON   all           * INPUT VALUES * 

   --------------------------------------------------------------------

    RATE (#/AC)   No.APPS &   SOIL  SOLUBIL  APPL TYPE  %CROPPED INCORP

     ONE(MULT)    INTERVAL    Koc   (PPM )   (%DRIFT)     AREA    (IN)

   --------------------------------------------------------------------

   .007(   .026)   4   7       2.9*******   GROUND( 6.4)  87.0    .0

   FIELD AND RESERVOIR HALFLIFE VALUES (DAYS) 

   --------------------------------------------------------------------

   METABOLIC  DAYS UNTIL  HYDROLYSIS   PHOTOLYSIS   METABOLIC  COMBINED

    (FIELD)  RAIN/RUNOFF  (RESERVOIR)  (RES.-EFF)   (RESER.)   (RESER.) 

   --------------------------------------------------------------------

     81.30        2          N/A       .00-     .00    58.10     58.10

   UNTREATED WATER CONC (MICROGRAMS/LITER (PPB)) Ver 1.1.0 DEC 12, 2005

   --------------------------------------------------------------------

        PEAK DAY  (ACUTE)      ANNUAL AVERAGE (CHRONIC)      

          CONCENTRATION             CONCENTRATION            

   --------------------------------------------------------------------

              2.323                     		  .381

   RUN No.   3 FOR SYN504851        ON   all           * INPUT VALUES * 

   --------------------------------------------------------------------

    RATE (#/AC)   No.APPS &   SOIL  SOLUBIL  APPL TYPE  %CROPPED INCORP

     ONE(MULT)    INTERVAL    Koc   (PPM )   (%DRIFT)     AREA    (IN)

   --------------------------------------------------------------------

   .027(   .099)   4   7       3.050000.0   GROUND( 6.4)  87.0    .0

   FIELD AND RESERVOIR HALFLIFE VALUES (DAYS) 

   --------------------------------------------------------------------

   METABOLIC  DAYS UNTIL  HYDROLYSIS   PHOTOLYSIS   METABOLIC  COMBINED

    (FIELD)  RAIN/RUNOFF  (RESERVOIR)  (RES.-EFF)   (RESER.)   (RESER.) 

   --------------------------------------------------------------------

     81.30        2          N/A       .00-     .00   ******   1323.00

   UNTREATED WATER CONC (MICROGRAMS/LITER (PPB)) Ver 1.1.0 DEC 12, 2005

   --------------------------------------------------------------------

        PEAK DAY  (ACUTE)      ANNUAL AVERAGE (CHRONIC)      

          CONCENTRATION             CONCENTRATION            

   --------------------------------------------------------------------

              8.993           		           5.858

SCI-GROW MODEL 2.3 INPUT & OUTPUT FILES

SCIGROW

VERSION 2.3

ENVIRONMENTAL FATE AND EFFECTS DIVISION

OFFICE OF PESTICIDE PROGRAMS

U.S. ENVIRONMENTAL PROTECTION AGENCY

SCREENING MODEL

FOR AQUATIC PESTICIDE EXPOSURE

 

 SciGrow version 2.3

 chemical:Manidpropamid

 time is  4/19/2007  16:20: 6

 -----------------------------------------------------------------------
-

  Application      Number of       Total Use    Koc      Soil Aerobic

  rate (lb/acre)  applications   (lb/acre/yr)  (ml/g)   metabolism
(days)

 -----------------------------------------------------------------------
-

      0.130           4.0           0.520      7.82E+02       75.1

 -----------------------------------------------------------------------
-

 groundwater screening cond (ppb) =   5.22E-02 

 ***********************************************************************
*

 

		SCIGROW

                          VERSION 2.3

            ENVIRONMENTAL FATE AND EFFECTS DIVISION

                 OFFICE OF PESTICIDE PROGRAMS

             U.S. ENVIRONMENTAL PROTECTION AGENCY

                        SCREENING MODEL

                FOR AQUATIC PESTICIDE EXPOSURE

 

 SciGrow version 2.3

 chemical:SYN00003

 time is  4/23/2007  15:55:32

 -----------------------------------------------------------------------
-

  Application      Number of       Total Use    Koc      Soil Aerobic

  rate (lb/acre)  applications   (lb/acre/yr)  (ml/g)   metabolism
(days)

 -----------------------------------------------------------------------
-

      0.007           4.0           0.028      2.92E+00       81.3

 -----------------------------------------------------------------------
-

 groundwater screening cond (ppb) =   5.85E-01 

 ***********************************************************************
*

 

                           SCIGROW

                          VERSION 2.3

            ENVIRONMENTAL FATE AND EFFECTS DIVISION

                 OFFICE OF PESTICIDE PROGRAMS

             U.S. ENVIRONMENTAL PROTECTION AGENCY

                        SCREENING MODEL

                FOR AQUATIC PESTICIDE EXPOSURE

 

 SciGrow version 2.3

 chemical:SYN504851

 time is  4/23/2007  15:56: 6

 -----------------------------------------------------------------------
-

  Application      Number of       Total Use    Koc      Soil Aerobic

  rate (lb/acre)  applications   (lb/acre/yr)  (ml/g)   metabolism
(days)

 -----------------------------------------------------------------------
-

      0.027           4.0           0.108      5.00E+00       81.3

 -----------------------------------------------------------------------
-

 groundwater screening cond (ppb) =   1.73E+00 

 ***********************************************************************
*

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