UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C.  20460

OFFICE OF              

PREVENTION, PESTICIDES

AND TOXIC SUBSTANCES 

MEMORANDUM

DATE:  	19-MAR-2008	

SUBJECT:	Fluopicolide Chronic Aggregate Dietary (Food and Drinking
Water) Exposure and Risk Assessment for the Section 3 Registration
Action for the Proposed Uses on Root Vegetables (Subgroup 1A), Leaves of
Root and Tuber Vegetables (Group 2), Bulb Vegetables (Group 3), and Head
and Stem Brassica (Subgroup 5A).

PC Code:	027412			Decision Number:  373401

DP Number:	349721

REVIEWER:	Sheila Piper, Chemist

Alternative Risk Integration Assessment Team (ARIA)

Risk Integration, Minor Use and Emergency Response (RIMUER) Branch

Registration Division-RD (7505P)

THROUGH:	Thurston Morton, Chemist

		Mohsen Sahafeyan, Chemist

		Dietary Exposure Science Advisory Council (DESAC)

Health Effects Division-HED (7509P)

and

William Cutchin, Acting Senior Branch Scientist

ARIA/RIMUERB/RD (7505P)

TO:		Felecia Fort, Risk Assessor

		Reregistration Action Branch 1

HED (7509P)

and

Janet Whitehurst/Tony Kish, RM Team #22

Fungicide Branch/RD (7505P)

	

Executive Summary

DEEM-FCID™, Version 2.03), which uses food consumption data from the
U.S. Department of Agriculture’s Continuing Surveys of Food Intakes by
Individuals (CSFII) from 1994-1996 and 1998.  The analysis was performed
to support Section 3 requests and permanent tolerances for fluopicolide
residues in/on root vegetables (Subgroup 1A), leaves of root and tuber
vegetables (Group 2), bulb vegetables (Group 3), and head and stem
Brassica (Subgroup 5A). 

A separate assessment (D439722, D. Rate & S.Piper, 19-MAR-08) is being
concurrently conducted for 2,6-dichlorobenzamide (BAM).  BAM is a
metabolite and/or environmental degradate of both fluopicolide and
dichlobenil.  BAM will not be included in the tolerance expression but
will be included in risk assessments for domestic crops. 

Acute and Cancer Dietary Exposure Results and Characterization

Acute and cancer dietary exposure and risk assessments were not
conducted for fluopicolide.  An acute dietary assessment was not
conducted because an endpoint attributable to a single dose was not
identified from the available data.  A cancer dietary assessment was not
conducted because fluopicolide is not likely to be carcinogenic to
humans.

Chronic Dietary (Food and Drinking Water) Exposure Results and
Characterization

The chronic dietary (food and drinking water) exposure assessment was a
conservative assessment using the recommended tolerance levels for root
vegetables, leaves of root and tuber vegetables, bulb vegetables, and
head and stem Brassica and assuming that 100% of the crop was treated. 
Some processing studies were available; default processing factors were
used in cases where an adequate processing studies were not available
for particular matrices in DEEM.  Since residues may be expected to
occur in rotational crops, tolerances are recommended for the rotational
crop wheat and a label restriction is recommended against rotation to
other crops which are not primary crops.  Based on a dairy cattle
feeding study and a poultry metabolism study, no livestock tolerances
are required. The estimated chronic drinking water concentration was
derived from modeling fluopicolide use on California lettuce with aerial
application. 

The results of the chronic dietary analysis for food and drinking water
are below the Agency’s level of concern (<100% cPAD) for all
population subgroups.  The dietary exposure is estimated at 0.014472
mg/kg/day for the general U.S. population (7% of the chronic Population
Adjusted Dose (cPAD)) and 0.022354 mg/kg/day (11% of the cPAD) for
children 1-2 yrs, the population subgroup with highest estimated chronic
dietary exposure to fluopicolide.  

I.	Introduction

Dietary risk assessment incorporates both exposure and toxicity of a
given pesticide.  For acute and chronic assessments, the risk is
expressed as a percentage of a maximum acceptable dose (i.e., the dose
which HED has concluded will result in no unreasonable adverse health
effects).  This dose is referred to as the population adjusted dose
(PAD).  The PAD is equivalent to point of departure (POD, NOAEL, LOAEL,
e.g.) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when
estimated dietary risk exceeds 100% of the PAD.  HED is generally
concerned when estimated cancer risk exceeds one in one million. 
References which discuss the acute and chronic risk assessments in more
detail are available on the EPA/pesticides web site: “Available   

Information on Assessing Exposure from Pesticides, A User’s Guide,”
21-JUN-2000, web link:      HYPERLINK
"http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf" 
http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf  ; or see
SOP 99.6 (20-AUG-1999).

The most recent dietary risk assessment for fluopicolide was conducted
by N.Dodd (21-NOV-07, DP340365).

II.	Residue Information

Tolerances have recently been established (40 CFR §180.627; Federal
Register dated 30-JAN-08) for residues of fluopicolide,
2,6-dichloro-N-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl]benzami
de, as an indicator of combined residues of fluopicolide and its
metabolite, 2,6-dichlorobenzamide (BAM). Tolerances range from 0.02 ppm
on vegetable, tuberous and corm to 25 ppm on vegetable, leafy, except
brassica.  No livestock tolerances have been established for
fluopicolide.  

  

As determined in a RARC meeting held on 19-JUL-07 and in an HED
Fluopicolide Team meeting on 13-NOV-07 , the residue of concern for the
tolerance expression for primary and rotational crops is fluopicolide
(parent) as an indicator of combined residues of fluopicolide and its
metabolite, BAM.  The residue of concern for  the risk assessment are
parent and BAM for all primary crops except tuberous and corm vegetables
and all rotational crops except the grain of cereal grains used as human
food.  The RARC recommended that (in addition to parent and BAM) PCA
should be included in the risk assessment for tuberous and corm
vegetables and P1X and PCA should be included in the risk assessment for
the grain portion of cereal grain rotational crops used as human food
(see Table A2 in the Appendix).  Residues of concern for primary and
rotational crops, livestock, and drinking water are shown in Table 1.

A separate risk assessment (D439722, D. Rate & S. Piper, 19-MAR-08) is
being conducted concurrently for BAM.  BAM is a metabolite and/or
environmental degradate of both fluopicolide and dichlobenil.  The BAM
assessment includes combined residues of BAM in food and drinking water
from uses of fluopicolide and dichlobenil. 



Table 1.  Summary of Fluopicolide Residues to be included in the Risk
Assessment and Tolerance Expression 

Matrix	Residues included in Risk Assessment	Residues included in
Tolerance Expression

Plants

(Tuberous and Corm Vegetables, Leafy Vegetables (except Brassica),
Fruiting Vegetables, Cucurbit Vegetables, and Grapes)	Primary Crops

	All primary crops except Tuberous and Corm Vegetables	fluopicolide
(parent) and BAM 	fluopicolide (parent) as an indicator of combined
residues of fluopicolide and BAM



	Tuberous and Corm Vegetables	fluopicolide (parent), BAM, and PCA



Rotational Crops

	All rotational crops except cereal grains	fluopicolide (parent) and BAM
fluopicolide (parent) as an indicator of combined residues of
fluopicolide and BAM

	Cereal grains: grain for human food 

	fluopicolide (parent), BAM, PCA, and P1X 





Cereal grains: forage/hay/straw and grain for livestock feed
fluopicolide (parent) and BAM 

	Livestock

	Ruminant	fluopicolide (parent) and BAM 	BAM

	Poultry



Drinking Water	fluopicolide (parent) and BAM 	Not applicable



Residue Data used for the Chronic Assessment:

 

Raw agricultural commodities (RAC’s):  The recommended/established
tolerance levels were used in this assessment for raw agricultural
commodities as shown in Table 2 below.  A previous dietary memo
(D340365, N.Dodd, 21-NOV-07) for fluopicolide was conducted for a
Section 3 requests for permanent tolerances for fluopicolide residues
in/on tuberous and corm vegetables, leafy vegetables (except Brassica),
fruiting vegetables, cucurbit vegetables, grapes and rotational crop
wheat.  The recommended tolerances are in Table A1 and Table A2 for
wheat residue values of this Attachment 1the Appendix.  

Table 2. 	Tolerance Summary for Fluopicolide

Commodity	Proposed Tolerance (ppm)	Recommended Tolerance (ppm)	Comments;
Correct Commodity Definition

Tolerances to be established under “(a) General”:

Root vegetables subgroup 1-A (except sugar beet and carrot)	0.15	0.15
Vegetable, root, subgroup 1A

Leaves of root and tuber vegetables, group 2	13	15	Vegetable, leaves of
root and tuber, group 2

Onion, bulb, group 3	6	Remove

	Individual tolerances are not required for members of the Vegetable,
bulb, group 3-07A



Onion, bulb	--



Fritillaria, bulb	--



Daylily, bulb 	--



Garlic, bulb	--



Garlic, great headed, bulb	--



Garlic, Serpent, bulb	--



Lily, bulb	--



Onion, Chinese, bulb	--



Onion, pearl	--



Onion, potato, bulb	--



Shallot, bulb	--



Onion, green

Remove	Individual tolerances are not required for members of the
Vegetable, green onion, group 3-07B



Chive, fresh leaves 	--



Chive, Chinese, fresh leaves	--



Elgans hosta	--



Fritillaria, leaves	--



Kurrat	--



Lady’s leek	--



Leek	--



Leek, wild	--



Onion, Beltsville bunching	--



Onion, fresh	--



Onion, macrostem	--



Onion, tree, tops	--



Onion, Welsh, tops	--



Shallot, fresh leaves	--



Onion, bulb, subgroup 3-07A	None proposed	7.0	Onion, bulb, subgroup
3-07A

Onion, green, subgroup 3-07B	None proposed	7.0	Onion, green, subgroup
3-07B

Head and stem Brassica subgroup 5-A 	5	5	Brassica, head and stem,
subgroup 5A



  



Processed Commodities: The available processing data indicate that
residues of fluopicolide are not likely to concentrate in grape juice,
potato chips and flakes, or wheat flour; therefore, concentration
factors were not used for grape juice, potato chips, dry potatoes
(granules/flakes), or wheat flour in this dietary assessment.  Residues
of fluopicolide were found to concentrate in raisins, processed potato
waste (wet peels), tomato paste and puree, and wheat milled byproducts
(bran, germ, middlings, and shorts).  The processing data indicate that
separate tolerances are needed for raisins, processed potato waste (a
livestock feed item), and wheat milled byproducts.  Instead of using a
concentration factor for raisins, the separate tolerance of 6.0 ppm for
raisins was used in this assessment.  Separate tolerances for tomato
paste and puree are not needed, as residues in these commodities are not
expected to exceed the recommended tolerance for the fruiting vegetable
group; therefore, no separate tolerance or concentration factor was
applied to tomato paste and puree. Default processing factors were used
if a processing study was not available for particular matrices; i.e.,
default processing factors of 6.5 for potato flour, 14.3 for dried
tomato, and 1.5 for tomato juice were used.

Rotational crops:  Since residues may be expected to occur in rotational
crops, tolerances are recommended for the rotational crop wheat and a
label restriction is recommended against rotation to crops other than
wheat and primary (treated) crops on the label.  

Livestock commodities: Based on the dairy cattle feeding study and a
poultry metabolism study conducted with fluopicolide, no livestock
tolerances are required for fluopicolide.  [Note:  Because of a
different toxicity profile, the metabolite BAM is being evaluated
separately. Livestock tolerances for BAM may be needed to support uses
with associated feed items (i.e., potato and wheat) pending
submission/reference of a BAM ruminant feeding study.]  

The chronic dietary (food and drinking water) exposure assessment for
fluopicolide was a conservative assessment using the
recommended/established tolerance levels and assuming that 100% of the
crop was treated.  

   Drinking Water Data

The drinking water residues used in the dietary risk assessment were
provided by the Environmental Fate and Effects Division (EFED) in the
following memorandum: “Drinking Water Exposure and Assessment for
Fluopicolide Uses on Grapes, Vegetables, Potatoes and Turf” (DP325804,
J. Lin, 7-MAR-07) and incorporated directly into this dietary
assessment.  Bases on the IR-4 use information, EFED has decided that
there is no need to perform additional drinking water assessment, due to
the reason that all the IR-4 use rates are either equal to or less than
all the application rates used in the previous drinking water
assessments for fluopicolide and BAM.  Therefore, the drinking water
concentrations should be based on the previous drinking water memos (see
DP325804 dated 26-JUN-07, 5-MAR-07, and 7-MAR-07).  Water residues were
incorporated in the DEEM-FCID into the food categories “water, direct,
all sources” and “water, indirect, all sources.”   

This drinking water exposure memo addresses the human exposure of
fluopicolide through ingestion of drinking water from uses on grapes,
vegetables and turf.  No monitoring data of fluopicolide were available
to the EFED.  Surface water concentrations were estimated using the Tier
II model PRZM (Pesticide Root Zone Model) version 3.12/ EXAMS (Exposure
Analysis Modeling System) version 2.98.  Ground water concentrations
were estimated using the Tier I SCI-GROW (Screening Concentration in
Ground Water) model.  Fluopicolide may be applied by aerial or ground as
per the label for this product.  The 7-MAR-07 memo only addresses the
estimations of parent fluopicolide.

Based on modeling results, the estimated surface water (drinking water)
concentrations for fluopicolide are:  

26.81 ug/L for the 1-in-10 year annual peak concentration (acute)  

8.34 ug/L for the 1-in-10 year annual mean concentration (non-cancer
chronic) and  

6.14 ug/L for the 30 year annual mean concentration (cancer chronic).   

The 1-in-10 year annual peak (acute) was derived from modeling
fluopicolide use on Florida peppers with ground applications.  The
1-in-10 year annual mean (non-cancer chronic) was derived from modeling
fluopicolide use on California lettuce with aerial applications.  The 30
year annual mean concentration (cancer chronic) was derived from
fluopicolide use on California lettuce with aerial applications.  These
values were highest among all modeling scenarios examined.  

The SCI-GROW estimated ground water (drinking water) concentrations for
fluopicolide are not expected to exceed 0.64 μg/L, which was based on 2
applications of 0.270 lb ai/acre per application.

This chronic dietary assessment used the value of 8.34 ug/L (ppb) for
drinking water.

The model and its description are available at the EPA internet site:  
HYPERLINK "http://www.epa.gov/oppefed1/models/water/" 
http://www.epa.gov/oppefed1/models/water/ .  

IV.	DEEM-FCID™ Program and Consumption Information

Fluopicolide chronic dietary exposure assessment was conducted using the
Dietary Exposure Evaluation Model software with the Food Commodity
Intake Database DEEM-FCID™, Version 2.03, which incorporates
consumption data from USDA’s Continuing Surveys of Food Intakes by
Individuals (CSFII), 1994-1996 and 1998.  The 1994-96, 98 data are based
on the reported consumption of more than 20,000 individuals over two
non-consecutive survey days.  Foods “as consumed” (e.g., apple pie)
are linked to EPA-defined food commodities (e.g. apples, peeled fruit -
cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S,
baked) using publicly available recipe translation files developed
jointly by USDA/ARS and EPA.  For chronic exposure assessment,
consumption data are averaged for the entire U.S. population and within
population subgroups, but for acute exposure assessment are retained as
individual consumption events.  Based on analysis of the 1994-96, 98
CSFII consumption data, which took into account dietary patterns and
survey respondents, HED concluded that it is most appropriate to report
risk for the following population subgroups: the general U.S.
population, all infants (<1 year old), children 1-2, children 3-5,
children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50+
years old.

For chronic dietary exposure assessment, an estimate of the residue
level in each food or food-form (e.g., orange or orange juice) on the
food commodity residue list is multiplied by the average daily
consumption estimate for that food/food form to produce a residue intake
estimate.  The resulting residue intake estimate for each food/food form
is summed with the residue intake estimates for all other food/food
forms on the commodity residue list to arrive at the total average
estimated exposure.  Exposure is expressed in mg/kg body weight/day and
as a percent of the cPAD.  This procedure is performed for each
population subgroup.

V.	Toxicological Information

The Fluopicolide Risk Assessment Team selected endpoints for this new
pesticide.  The Fluopicolide CARC was held on 15-NOV-06.  An HED
metabolism assessment meeting was held on 07-DEC-06 to discuss imported
grapes.  The RARC for imported grapes was held on 21-DEC-06.  The RARC1
for domestic uses was held on 19-JUL-07.  It was recommended that the
10X FQPA safety factor for the protection of infants and children be
removed.  The database is adequate and although there was not a
developmental neurotoxicity study, evidence from other studies indicate
that one is not required.  The acute and subchronic neurotoxicity
studies showed no gross or microscopic brain pathology associated with
this test substance, and none of the studies indicated any clinical
signs of toxicity that would be associated with neurological function as
shown in Table 3.



  TC \l3 "3.5.10	Summary of Toxicological Doses and Endpoints for
Prothioconazole for Use in Human Risk Assessments 

Table 3.   Summary of Toxicological Doses and Endpoints for Fluopicolide
for Use in Dietary Exposure Risk Assessments

Exposure/

Scenario	Point of Departure	Uncertainty/FQPA Safety Factors	RfD, PAD,
Level of Concern 	Study and Toxicological Effects

Acute Dietary (All Populations)	None	None	None	An endpoint attributable
to a single dose was not identified from the available data.

Chronic Dietary (All Populations)	Maternal NOAEL=20 mg/kg/day

NOAEL =31.5 mg/kg/day (co-critical study)

	UFA=10x

UFH=10x

FQPA SF = 1X

	Chronic RfD = 

0.2 mg/kg/day

cPAD = 0.2 mg/kg/day	Developmental Toxicity Study in Rabbits

LOAEL (maternal) = 60 mg/kg/day based on death, abortions/premature
deliveries, decreased food consumption and body weight gain.

Chronic Oncogenicity Study in Rats 

LOAEL (co-critical study) = 109.4 mg/kg/day based on decreased body
weight gain and increased thyroid weight and increased incidence of
thyroid lesions.

Cancer (oral, dermal, inhalation)	Classification:  “Not Likely to be
Carcinogenic to Humans”



Point of Departure (POD) = A data point or an estimated point that is
derived from observed dose-response data and  used to mark the beginning
of extrapolation to determine risk associated with lower environmentally
relevant human exposures.  NOAEL = no observed adverse effect level. 
LOAEL = lowest observed adverse effect level.  UF = uncertainty factor. 
UFA = extrapolation from animal to human (interspecies).  UFH =
potential variation in sensitivity among members of the human population
(intraspecies).  FQPA SF = FQPA Safety Factor.  PAD = population
adjusted dose (c = chronic).  RfD = reference dose. 



VI.	Results/Discussion  

 PAD.  The DEEM-FCID™ analyses estimate the dietary exposure of the
U.S. population and various population subgroups.  The results reported
in Table 4 are for the general U.S. Population, all infants (<1 year
old), children 1-2, children 3-5, children 6-12, youth 13-19, females
13-49, adults 20-49, and adults 50+ years.

Results of Chronic Dietary (Food and Drinking Water) Exposure Analysis

The chronic dietary (food and drinking water) exposure assessment was a
conservative assessment using the recommended tolerance levels for root
vegetables, leaves of root and tuber vegetables, bulb vegetables, and
head and stem Brassica and assuming that 100% of the crop was treated. 
Some processing studies were available; default processing factors were
used in cases where an adequate processing study was not available for
particular matrices in DEEM.  Since residues may be expected to occur in
rotational crops, tolerances are recommended for the rotational crop
wheat and a label restriction is recommended against rotation to other
crops which are not primary crops.  Based on a dairy cattle feeding
study and a poultry metabolism study, no livestock tolerances are
required. The estimated chronic drinking water concentration was derived
from modeling fluopicolide use on California lettuce with aerial
application. [Note:  Because of a different toxicity profile, the
metabolite BAM is being evaluated separately (D439722, D. Rate &
S.Piper, 18-MAR-08).  Livestock tolerances for BAM may be needed to
support uses with associated feed items (i.e., potato and wheat) pending
submission/reference of a BAM ruminant feeding study.]   

The chronic dietary (food and drinking water) exposure to fluopicolide
is below HED’s level of concern for the general U.S. population and
all population subgroups.  The chronic dietary exposure estimates are 7%
cPAD for the general U.S. population and 11% cPAD for children 1-2 years
old, the most highly exposed subgroup.  

Table 4.  Summary of Dietary (Food and Drinking Water) Exposure and Risk
for Fluopicolide

Population Subgroup	Acute Dietary	Chronic Dietary	Cancer

	Dietary Exposure (mg/kg/day)	% aPAD	Dietary Exposure

(mg/kg/day)	% cPAD	Dietary Exposure

(mg/kg/day)	Risk

General U.S. Population	N/A	N/A	0.014472	7	N/A	N/A

All Infants (< 1 year old)

	0.008784	4



Children 1-2 years old

	0.022354	11



Children 3-5 years old

	0.019967	10



Children 6-12 years old

	0.014955	8



Youth 13-19 years old

	0.011643	6



Adults 20-49 years old

	0.014271	7



Adults 50+ years old

	0.014074	7



Females 13-49 years old

	0.014280	7





VII.	Characterization of Inputs/Outputs

A conservative chronic dietary (food and drinking water) exposure
assessment was conducted.   Recommended/established tolerance level
residues of fluopicolide (parent) based on field trials were used for
all crops.  Some processing studies were available; default processing
factors were used in cases where an adequate processing study was not
available for particular matrices in DEEM. The assessment assumed 100%
of the crop was treated.  Although not needed at this time, HED could
refine the exposure and risk estimates with the following information:
1) projected market share/percent crop treated data; and 2) anticipated
residue data.

  

VIII.	Conclusions

A chronic dietary (food and drinking water) exposure assessment was
conducted for the proposed uses on root vegetables, leaves of root and
tuber vegetables, bulb vegetables, and head and stem Brassica.  A
conservative assessment was conducted using tolerance level residues and
assuming 100% of the crop was treated.  

The results of the chronic dietary analysis for food and drinking water
are below the Agency’s level of concern (<100% cPAD) for all
population subgroups.  The dietary exposure is estimated at 0.014472
mg/kg/day for the general U.S. population (7% of the cPAD) and 0.022354
mg/kg/day (11% of the cPAD) for children 1-2 yrs, the population
subgroup with highest estimated chronic dietary exposure to
fluopicolide.  

Appendix

IX.		List of Attachments

1.	Tolerances Summary for Fluopicolide

A1.  Previous Tolerances to be established under 180.627(a)General (1)
for PP#5F7016

A2. Calculation of Residues for the Dietary Assessment for the RAW
Agricultural Commodities Potato and Wheat

2.	Chronic Food plus Water Residue Input File (Alphabetic)

3.	Chronic Food plus Water Residue Input File (Crop Group)

4.	Chronic Food plus Water Results File

Attachment A1:  Previous Tolerances to be established under
180.627(a)General (1) for PP#5F7016

Table A1. 	Tolerance Summary for Fluopicolide

Commodity	Proposed Tolerance (ppm)	Recommended Tolerance (ppm)	Comments;
Correct Commodity Definition

Tolerances to be established under “(a) General” (1):

Tuberous and corm vegetables subgroup 1C

Arracacha 	0.02	0.091	Vegetable, tuberous and corm, except potato,
subgroup 1D

Arrowroot 	0.02



Artichoke, Chinese 	0.02



Artichoke, Jerusalem 	0.02



Canna, edible 	0.02



Cassava, bitter and sweet 	0.02



Chayote (root) 	0.02



Chufa 	0.02



Dasheen 	0.02



Ginger 	0.02



Leren 	0.02



Sweet potato 	0.02



Tanier 	0.02



Turmeric 	            0.02



Yam bean 	            0.02



Yam, true 	2



Vegetable, leafy, except Brassica, group 4

Head Lettuce 	20	25	Vegetable, leafy, except brassica, group 4

Leaf Lettuce 	20



Spinach 	20



Arugula 	20



Chervil 	20



Chinese spinach 	20



Corn salad 	20



Dandelion 	20



Dock (sorrel) 	20



Edible chrysanthemum 	20



Endive 	20



Garden cress 	20



Garden purslane 	20



Garland Chrysanthemum 	20



New Zealand spinach 	20



Orach 	20



Parsley 	20



Red chicory 	20



Upland cress 	20



Vine spinach 	20



Winter purslane 	20



Cardoon 	20



Celery 	20



Celtuce 	20



Chinese celery 	              20



Fennel 	20



Rhubarb 	20



Swiss chard 	20



Vegetable, fruiting, group 8

Tomato/Cherry tomato 	0.8	1.6	Vegetable, fruiting, group 8

Sweet pepper 	0.8



Bell pepper 	0.8



Chili pepper 	0.8



Cooking pepper 	0.8



Pimiento 	0.8



Eggplant 	0.8



Groundcherry 	0.8



Pepino 	0.8



Tomatillo 	             0.8



Vegetable, cucurbit, group 9

Cantaloupe 	0.4	0.50	Vegetable, cucurbit, group 9

Citron melon 	0.4



Muskmelon 	0.4



Watermelon	0.4



Chayote (fruit) 	0.4



Chinese waxgourd 	0.4



Cucumber 	0.4



Gherkin 	0.4



Gourd, edible 	0.4



Momordica spp 	0.4



Pumpkin 	0.4



Squash, summer 	0.4



Squash, winter 	             0.4



Other

Grape 	2	2.0

	Raisins 	6	6.0	Grape, raisin

1Recommended tolerance for tuberous and corm vegetables include the
conversion factor that convert residues reported as PCA and P1X to
fluopicolide (parent) equivalents using molecular weight ratios.

2 See N.Dodd, D340365 memo, dated 21-NOV-07

 Potato and Wheat

0.0886 ≈ 0.09

Wheat grain	Parent	0.014	Not applicable	0.014

	PCA	0.062	1.701	0.10546

	P1X	0.075	1.515	0.1136

	Total

	0.2331 ≈ 0.23

Wheat germ 	Parent	0.014

0.0658

	PCA	0.10546

0.09491

	P1X	0.1136

0.07952

	Total

	0.24023 ≈ 0.24

Wheat bran	Parent	0.014

0.0420

	PCA	0.10546

0.2004

	P1X	0.1136

0.2499

	Total

	0.4923 ≈ 0.49

1 BAM is assessed in a separate memo.

2 Conversion factors convert residues reported as PCA and P1X to
fluopicolide (parent) equivalents using molecular weight ratios. 
Molecular weights are 383.584 for parent, 225.554 for PCA, and 253.196
for P1X.  Conversion factors are calculated as follows: 383.584 ÷
225.554 = 1.701 for conversion of PCA to parent equivalents; 383.584 ÷
253.196 = 1.515 for conversion of P1X to parent equivalents. [See
N.Dodd, D340365 memo, dated 21-NOV-07]

Attachment 2:  Chronic Food plus Water Residue Input File (Alphabetic)

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for FLUOPICOLIDE                      
1994-98 data

Residue file: C:\DEEMFCID\BAM\fluopicolideDomChronicPP7E71712.R98

                                                               Adjust.
#2 used

Analysis Date 02-25-2008             Residue file dated:
02-25-2008/09:37:57/8

Reference dose (RfD) = 0.2 mg/kg bw/day

Comment:New uses from PP#7E7172

------------------------------------------------------------------------
--------

Food Crop                                       Residue      
Adj.Factors      Comment

EPA Code  Grp  Food Name                          (ppm)       

                                                             #1        
#2 

-------- ---- -------------------------------   ---------- ------    
------   -------

04010050 4A   Amaranth, leafy                   25.000000   1.000     
1.000   

01030150 1CD  Arrowroot, flour                   0.090000   1.000     
1.000   

01030151 1CD  Arrowroot, flour-babyfood          0.090000   1.000     
1.000   

01030170 1CD  Artichoke, Jerusalem               0.090000   1.000     
1.000   

04010180 4A   Arugula                           25.000000   1.000     
1.000   

09020210 9B   Balsam pear                        0.500000   1.000     
1.000   

01010500 1AB  Beet, garden, roots                0.150000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

01010501 1AB  Beet, garden, roots-babyfood       0.150000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

02000510 2    Beet, garden, tops                15.000000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

05010610 5A   Broccoli                           5.000000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

05010611 5A   Broccoli-babyfood                  5.000000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

05010620 5A   Broccoli, Chinese                  5.000000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

05010640 5A   Brussels sprouts                   5.000000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

01010670 1AB  Burdock                            0.150000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

05010690 5A   Cabbage                            5.000000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

05010710 5A   Cabbage, Chinese, napa             5.000000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

05010720 5A   Cabbage, Chinese, mustard          5.000000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

09010750 9A   Cantaloupe                         0.500000   1.000     
1.000   

04020760 4B   Cardoon                           25.000000   1.000     
1.000   

09010800 9A   Casaba                             0.500000   1.000     
1.000   

01030820 1CD  Cassava                            0.090000   1.000     
1.000   

01030821 1CD  Cassava-babyfood                   0.090000   1.000     
1.000   

05010830 5A   Cauliflower                        5.000000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

01010840 1AB  Celeriac                           0.150000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

04020850 4B   Celery                            25.000000   1.000     
1.000   

04020851 4B   Celery-babyfood                   25.000000   1.000     
1.000   

04020860 4B   Celery, juice                     25.000000   1.000     
1.000   

04020870 4B   Celtuce                           25.000000   1.000     
1.000   

09020880 9B   Chayote, fruit                     0.500000   1.000     
1.000   

01011000 1AB  Chicory, roots                     0.150000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

02001010 2    Chicory, tops                     15.000000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

09021020 9B   Chinese waxgourd                   0.500000   1.000     
1.000   

19011030 19A  Chive                              8.000000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

04011040 4A   Chrysanthemum, garland            25.000000   1.000     
1.000   

04011330 4A   Cress, garden                     25.000000   1.000     
1.000   

04011340 4A   Cress, upland                     25.000000   1.000     
1.000   

09021350 9B   Cucumber                           0.500000   1.000     
1.000   

04011380 4A   Dandelion, leaves                 25.000000   1.000     
1.000   

01031390 1CD  Dasheen, corm                      0.090000   1.000     
1.000   

02001400 2    Dasheen, leaves                   15.000000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

08001480 8    Eggplant                           1.600000   1.000     
1.000   

04011500 4A   Endive                            25.000000   1.000     
1.000   

04021520 4B   Fennel, Florence                  25.000000   1.000     
1.000   

03001640 3    Garlic                             7.000000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

03001650 3    Garlic, dried                      7.000000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

03001651 3    Garlic, dried-babyfood             7.000000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

01031660 1CD  Ginger                             0.090000   1.000     
1.000   

01031661 1CD  Ginger-babyfood                    0.090000   1.000     
1.000   

01031670 1CD  Ginger, dried                      0.090000   1.000     
1.000   

01011680 1AB  Ginseng, dried                     0.150000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

95001750 O    Grape                              2.000000   1.000     
1.000   

95001760 O    Grape, juice                       2.000000   1.000     
1.000   

95001761 O    Grape, juice-babyfood              2.000000   1.000     
1.000   

95001770 O    Grape, leaves                      2.000000   1.000     
1.000   

95001780 O    Grape, raisin                      6.000000   1.000     
1.000   

95001790 O    Grape, wine and sherry             2.000000   1.000     
1.000   

09011870 9A   Honeydew melon                     0.500000   1.000     
1.000   

01011900 1AB  Horseradish                        0.150000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

05011960 5A   Kohlrabi                           5.000000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

03001980 3    Leek                               7.000000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

04012040 4A   Lettuce, head                     25.000000   1.000     
1.000   

04012050 4A   Lettuce, leaf                     25.000000   1.000     
1.000   

08002340 8    Okra                               1.600000   1.000     
1.000   

03002370 3    Onion, dry bulb                    7.000000   1.000     
1.000   

03002371 3    Onion, dry bulb-babyfood           7.000000   1.000     
1.000   

03002380 3    Onion, dry bulb, dried             7.000000   9.000     
1.000   

03002381 3    Onion, dry bulb, dried-babyfood    7.000000   9.000     
1.000   

03002390 3    Onion, green                       7.000000   1.000     
1.000   

04012480 4A   Parsley, leaves                   25.000000   1.000     
1.000   

01012500 1AB  Parsley, turnip rooted             0.150000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

01012510 1AB  Parsnip                            0.150000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

01012511 1AB  Parsnip-babyfood                   0.150000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

08002700 8    Pepper, bell                       1.600000   1.000     
1.000   

08002701 8    Pepper, bell-babyfood              1.600000   1.000     
1.000   

08002710 8    Pepper, bell, dried                1.600000   1.000     
1.000   

08002711 8    Pepper, bell, dried-babyfood       1.600000   1.000     
1.000   

08002720 8    Pepper, nonbell                    1.600000   1.000     
1.000   

08002721 8    Pepper, nonbell-babyfood           1.600000   1.000     
1.000   

08002730 8    Pepper, nonbell, dried             1.600000   1.000     
1.000   

01032960 1C   Potato, chips                      0.090000   1.000     
1.000   

01032970 1C   Potato, dry (granules/ flakes)     0.090000   1.000     
1.000   

01032971 1C   Potato, dry (granules/ flakes)-b   0.090000   1.000     
1.000   

01032980 1C   Potato, flour                      0.090000   6.500     
1.000   

01032981 1C   Potato, flour-babyfood             0.090000   6.500     
1.000   

01032990 1C   Potato, tuber, w/peel              0.090000   1.000     
1.000   

01032991 1C   Potato, tuber, w/peel-babyfood     0.090000   1.000     
1.000   

01033000 1C   Potato, tuber, w/o peel            0.090000   1.000     
1.000   

01033001 1C   Potato, tuber, w/o peel-babyfood   0.090000   1.000     
1.000   

09023080 9B   Pumpkin                            0.500000   1.000     
1.000   

09023090 9B   Pumpkin, seed                      0.500000   1.000     
1.000   

04013130 4A   Radicchio                         25.000000   1.000     
1.000   

01013140 1AB  Radish, roots                      0.150000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

02003150 2    Radish, tops                      15.000000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

01013160 1AB  Radish, Oriental, roots            0.150000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

02003170 2    Radish, Oriental, tops            15.000000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

04023220 4B   Rhubarb                           25.000000   1.000     
1.000   

01013270 1AB  Rutabaga                           0.150000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

01013310 1AB  Salsify, roots                     0.150000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

02003320 2    Salsify, tops                     15.000000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

03003380 3    Shallot                            7.000000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

04013550 4A   Spinach                           25.000000   1.000     
1.000   

04013551 4A   Spinach-babyfood                  25.000000   1.000     
1.000   

09023560 9B   Squash, summer                     0.500000   1.000     
1.000   

09023561 9B   Squash, summer-babyfood            0.500000   1.000     
1.000   

09023570 9B   Squash, winter                     0.500000   1.000     
1.000   

09023571 9B   Squash, winter-babyfood            0.500000   1.000     
1.000   

01033660 1CD  Sweet potato                       0.090000   1.000     
1.000   

01033661 1CD  Sweet potato-babyfood              0.090000   1.000     
1.000   

04023670 4B   Swiss chard                       25.000000   1.000     
1.000   

01033710 1CD  Tanier, corm                       0.090000   1.000     
1.000   

08003740 8    Tomatillo                          1.600000   1.000     
1.000   

08003750 8    Tomato                             1.600000   1.000     
1.000   

08003751 8    Tomato-babyfood                    1.600000   1.000     
1.000   

08003760 8    Tomato, paste                      1.600000   1.000     
1.000   

08003761 8    Tomato, paste-babyfood             1.600000   1.000     
1.000   

08003770 8    Tomato, puree                      1.600000   1.000     
1.000   

08003771 8    Tomato, puree-babyfood             1.600000   1.000     
1.000   

08003780 8    Tomato, dried                      1.600000  14.300     
1.000   

08003781 8    Tomato, dried-babyfood             1.600000  14.300     
1.000   

08003790 8    Tomato, juice                      1.600000   1.500     
1.000   

01033870 1CD  Turmeric                           0.090000   1.000     
1.000   

01013880 1AB  Turnip, roots                      0.150000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

86010000 O    Water, direct, all sources         0.008340   1.000     
1.000   

86020000 O    Water, indirect, all sources       0.008340   1.000     
1.000   

09013990 9A   Watermelon                         0.500000   1.000     
1.000   

09014000 9A   Watermelon, juice                  0.500000   1.000     
1.000   

15004010 15   Wheat, grain                       0.230000   1.000     
1.000   

15004011 15   Wheat, grain-babyfood              0.230000   1.000     
1.000   

15004020 15   Wheat, flour                       0.230000   1.000     
1.000   

15004021 15   Wheat, flour-babyfood              0.230000   1.000     
1.000   

15004030 15   Wheat, germ                        0.240000   1.000     
1.000   

15004040 15   Wheat, bran                        0.490000   1.000     
1.000   

01034060 1CD  Yam, true                          0.090000   1.000     
1.000   

01034070 1CD  Yam bean                           0.090000   1.000     
1.000   

Attachment 3:  Chronic Food plus Water Residue Input File (Crop Group)

Filename: C:\DEEMFCID\BAM\fluopicolideDomChronicPP7E71712.R98

Chemical: fluopicolide

RfD(Chronic): .2 mg/kg bw/day  NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): 0 mg/kg bw/day  NOEL(Acute):  0 mg/kg bw/day

Date created/last modified: 02-25-2008/09:37:57/8          Program ver.
2.03

Comment: New uses from PP#7E7172

------------------------------------------------------------------------
--------

  EPA    Crop                                   Def Res     Adj.Factors 
 Comment

  Code    Grp  Commodity Name                    (ppm)       #1    #2   

-------- ---- -------------------------------  ----------  ------ ------
 -------

95001750 O    Grape                              2.000000   1.000  1.000
 

95001760 O    Grape, juice                       2.000000   1.000  1.000
 

95001761 O    Grape, juice-babyfood              2.000000   1.000  1.000
 

95001770 O    Grape, leaves                      2.000000   1.000  1.000
 

95001780 O    Grape, raisin                      6.000000   1.000  1.000
 

95001790 O    Grape, wine and sherry             2.000000   1.000  1.000
 

86010000 O    Water, direct, all sources         0.008340   1.000  1.000
 

86020000 O    Water, indirect, all sources       0.008340   1.000  1.000
 

01030150 1CD  Arrowroot, flour                   0.090000   1.000  1.000
 

01030151 1CD  Arrowroot, flour-babyfood          0.090000   1.000  1.000
 

01030170 1CD  Artichoke, Jerusalem               0.090000   1.000  1.000
 

01010500 1AB  Beet, garden, roots                0.150000   1.000  1.000
 PP#7E7

          Full comment: PP#7E7172

01010501 1AB  Beet, garden, roots-babyfood       0.150000   1.000  1.000
 PP#7E7

          Full comment: PP#7E7172

01010670 1AB  Burdock                            0.150000   1.000  1.000
 PP#7E7

          Full comment: PP#7E7172

01030820 1CD  Cassava                            0.090000   1.000  1.000
 

01030821 1CD  Cassava-babyfood                   0.090000   1.000  1.000
 

01010840 1AB  Celeriac                           0.150000   1.000  1.000
 PP#7E7

          Full comment: PP#7E7172

01011000 1AB  Chicory, roots                     0.150000   1.000  1.000
 PP#7E7

          Full comment: PP#7E7172

01031390 1CD  Dasheen, corm                      0.090000   1.000  1.000
 

01031660 1CD  Ginger                             0.090000   1.000  1.000
 

01031661 1CD  Ginger-babyfood                    0.090000   1.000  1.000
 

01031670 1CD  Ginger, dried                      0.090000   1.000  1.000
 

01011680 1AB  Ginseng, dried                     0.150000   1.000  1.000
 PP#7E7

          Full comment: PP#7E7172

01011900 1AB  Horseradish                        0.150000   1.000  1.000
 PP#7E7

          Full comment: PP#7E7172

01012500 1AB  Parsley, turnip rooted             0.150000   1.000  1.000
 PP#7E7

          Full comment: PP#7E7172

01012510 1AB  Parsnip                            0.150000   1.000  1.000
 PP#7E7

          Full comment: PP#7E7172

01012511 1AB  Parsnip-babyfood                   0.150000   1.000  1.000
 PP#7E7

          Full comment: PP#7E7172

01032960 1C   Potato, chips                      0.090000   1.000  1.000
 

01032970 1C   Potato, dry (granules/ flakes)     0.090000   1.000  1.000
 

01032971 1C   Potato, dry (granules/ flakes)-b   0.090000   1.000  1.000
 

01032980 1C   Potato, flour                      0.090000   6.500  1.000
 

01032981 1C   Potato, flour-babyfood             0.090000   6.500  1.000
 

01032990 1C   Potato, tuber, w/peel              0.090000   1.000  1.000
 

01032991 1C   Potato, tuber, w/peel-babyfood     0.090000   1.000  1.000
 

01033000 1C   Potato, tuber, w/o peel            0.090000   1.000  1.000
 

01033001 1C   Potato, tuber, w/o peel-babyfood   0.090000   1.000  1.000
 

01013140 1AB  Radish, roots                      0.150000   1.000  1.000
 PP#7E7

          Full comment: PP#7E7172

01013160 1AB  Radish, Oriental, roots            0.150000   1.000  1.000
 PP#7E7

          Full comment: PP#7E7172

01013270 1AB  Rutabaga                           0.150000   1.000  1.000
 PP#7E7

          Full comment: PP#7E7172

01013310 1AB  Salsify, roots                     0.150000   1.000  1.000
 PP#7E7

          Full comment: PP#7E7172

01033660 1CD  Sweet potato                       0.090000   1.000  1.000
 

01033661 1CD  Sweet potato-babyfood              0.090000   1.000  1.000
 

01033710 1CD  Tanier, corm                       0.090000   1.000  1.000
 

01033870 1CD  Turmeric                           0.090000   1.000  1.000
 

01013880 1AB  Turnip, roots                      0.150000   1.000  1.000
 PP#7E7

          Full comment: PP#7E7172

01034060 1CD  Yam, true                          0.090000   1.000  1.000
 

01034070 1CD  Yam bean                           0.090000   1.000  1.000
 

02000510 2    Beet, garden, tops                15.000000   1.000  1.000
 PP#7E7

          Full comment: PP#7E7172

02001010 2    Chicory, tops                     15.000000   1.000  1.000
 PP#7E7

          Full comment: PP#7E7172

02001400 2    Dasheen, leaves                   15.000000   1.000  1.000
 PP#7E7

          Full comment: PP#7E7172

02003150 2    Radish, tops                      15.000000   1.000  1.000
 PP#7E7

          Full comment: PP#7E7172

02003170 2    Radish, Oriental, tops            15.000000   1.000  1.000
 PP#7E7

          Full comment: PP#7E7172

02003320 2    Salsify, tops                     15.000000   1.000  1.000
 PP#7E7

          Full comment: PP#7E7172

03001640 3    Garlic                             7.000000   1.000  1.000
 PP#7E7

          Full comment: PP#7E7172

03001650 3    Garlic, dried                      7.000000   1.000  1.000
 PP#7E7

          Full comment: PP#7E7172

03001651 3    Garlic, dried-babyfood             7.000000   1.000  1.000
 PP#7E7

          Full comment: PP#7E7172

03001980 3    Leek                               7.000000   1.000  1.000
 PP#7E7

          Full comment: PP#7E7172

03002370 3    Onion, dry bulb                    7.000000   1.000  1.000
 

03002371 3    Onion, dry bulb-babyfood           7.000000   1.000  1.000
 

03002380 3    Onion, dry bulb, dried             7.000000   1.000  1.000
 

03002381 3    Onion, dry bulb, dried-babyfood    7.000000   1.000  1.000
 

03002390 3    Onion, green                       7.000000   1.000  1.000
 

03003380 3    Shallot                            7.000000   1.000  1.000
 PP#7E7

          Full comment: PP#7E7172

04010050 4A   Amaranth, leafy                   25.000000   1.000  1.000
 

04010180 4A   Arugula                           25.000000   1.000  1.000
 

04020760 4B   Cardoon                           25.000000   1.000  1.000
 

04020850 4B   Celery                            25.000000   1.000  1.000
 

04020851 4B   Celery-babyfood                   25.000000   1.000  1.000
 

04020860 4B   Celery, juice                     25.000000   1.000  1.000
 

04020870 4B   Celtuce                           25.000000   1.000  1.000
 

04011040 4A   Chrysanthemum, garland            25.000000   1.000  1.000
 

04011330 4A   Cress, garden                     25.000000   1.000  1.000
 

04011340 4A   Cress, upland                     25.000000   1.000  1.000
 

04011380 4A   Dandelion, leaves                 25.000000   1.000  1.000
 

04011500 4A   Endive                            25.000000   1.000  1.000
 

04021520 4B   Fennel, Florence                  25.000000   1.000  1.000
 

04012040 4A   Lettuce, head                     25.000000   1.000  1.000
 

04012050 4A   Lettuce, leaf                     25.000000   1.000  1.000
 

04012480 4A   Parsley, leaves                   25.000000   1.000  1.000
 

04013130 4A   Radicchio                         25.000000   1.000  1.000
 

04023220 4B   Rhubarb                           25.000000   1.000  1.000
 

04013550 4A   Spinach                           25.000000   1.000  1.000
 

04013551 4A   Spinach-babyfood                  25.000000   1.000  1.000
 

04023670 4B   Swiss chard                       25.000000   1.000  1.000
 

05010610 5A   Broccoli                           5.000000   1.000  1.000
 PP#7E7

          Full comment: PP#7E7172

05010611 5A   Broccoli-babyfood                  5.000000   1.000  1.000
 PP#7E7

          Full comment: PP#7E7172

05010620 5A   Broccoli, Chinese                  5.000000   1.000  1.000
 PP#7E7

          Full comment: PP#7E7172

05010640 5A   Brussels sprouts                   5.000000   1.000  1.000
 PP#7E7

          Full comment: PP#7E7172

05010690 5A   Cabbage                            5.000000   1.000  1.000
 PP#7E7

          Full comment: PP#7E7172

05010710 5A   Cabbage, Chinese, napa             5.000000   1.000  1.000
 PP#7E7

          Full comment: PP#7E7172

05010720 5A   Cabbage, Chinese, mustard          5.000000   1.000  1.000
 PP#7E7

          Full comment: PP#7E7172

05010830 5A   Cauliflower                        5.000000   1.000  1.000
 PP#7E7

          Full comment: PP#7E7172

05011960 5A   Kohlrabi                           5.000000   1.000  1.000
 PP#7E7

          Full comment: PP#7E7172

08001480 8    Eggplant                           1.600000   1.000  1.000
 

08002340 8    Okra                               1.600000   1.000  1.000
 

08002700 8    Pepper, bell                       1.600000   1.000  1.000
 

08002701 8    Pepper, bell-babyfood              1.600000   1.000  1.000
 

08002710 8    Pepper, bell, dried                1.600000   1.000  1.000
 

08002711 8    Pepper, bell, dried-babyfood       1.600000   1.000  1.000
 

08002720 8    Pepper, nonbell                    1.600000   1.000  1.000
 

08002721 8    Pepper, nonbell-babyfood           1.600000   1.000  1.000
 

08002730 8    Pepper, nonbell, dried             1.600000   1.000  1.000
 

08003740 8    Tomatillo                          1.600000   1.000  1.000
 

08003750 8    Tomato                             1.600000   1.000  1.000
 

08003751 8    Tomato-babyfood                    1.600000   1.000  1.000
 

08003760 8    Tomato, paste                      1.600000   1.000  1.000
 

08003761 8    Tomato, paste-babyfood             1.600000   1.000  1.000
 

08003770 8    Tomato, puree                      1.600000   1.000  1.000
 

08003771 8    Tomato, puree-babyfood             1.600000   1.000  1.000
 

08003780 8    Tomato, dried                      1.600000  14.300  1.000
 

08003781 8    Tomato, dried-babyfood             1.600000  14.300  1.000
 

08003790 8    Tomato, juice                      1.600000   1.500  1.000
 

09020210 9B   Balsam pear                        0.500000   1.000  1.000
 

09010750 9A   Cantaloupe                         0.500000   1.000  1.000
 

09010800 9A   Casaba                             0.500000   1.000  1.000
 

09020880 9B   Chayote, fruit                     0.500000   1.000  1.000
 

09021020 9B   Chinese waxgourd                   0.500000   1.000  1.000
 

09021350 9B   Cucumber                           0.500000   1.000  1.000
 

09011870 9A   Honeydew melon                     0.500000   1.000  1.000
 

09023080 9B   Pumpkin                            0.500000   1.000  1.000
 

09023090 9B   Pumpkin, seed                      0.500000   1.000  1.000
 

09023560 9B   Squash, summer                     0.500000   1.000  1.000
 

09023561 9B   Squash, summer-babyfood            0.500000   1.000  1.000
 

09023570 9B   Squash, winter                     0.500000   1.000  1.000
 

09023571 9B   Squash, winter-babyfood            0.500000   1.000  1.000
 

09013990 9A   Watermelon                         0.500000   1.000  1.000
 

09014000 9A   Watermelon, juice                  0.500000   1.000  1.000
 

15004010 15   Wheat, grain                       0.230000   1.000  1.000
 

15004011 15   Wheat, grain-babyfood              0.230000   1.000  1.000
 

15004020 15   Wheat, flour                       0.230000   1.000  1.000
 

15004021 15   Wheat, flour-babyfood              0.230000   1.000  1.000
 

15004030 15   Wheat, germ                        0.240000   1.000  1.000
 

15004040 15   Wheat, bran                        0.490000   1.000  1.000
 

19011030 19A  Chive                              8.000000   1.000  1.000
 PP#7E7

          Full comment: PP#7E7172

Attachment 4:  Chronic Food plus Water Results File

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for FLUOPICOLIDE                     (1994-98
data)

Residue file name: C:\DEEMFCID\BAM\fluopicolideDomChronicPP7E71712.R98

                                                     Adjustment factor
#2 used.

Analysis Date 02-25-2008/09:38:30     Residue file dated:
02-25-2008/09:37:57/8

Reference dose (RfD, Chronic) = .2 mg/kg bw/day

COMMENT 1: New uses from PP#7E7172

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg             Percent
of   

           Subgroup                       body wt/day             Rfd   
   

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               7.1%

U.S. Population (autumn season)             0.014415                
7.2%

U.S. Population (winter season)             0.014592                
7.3%

Northeast region                            0.015280                
7.6%

Midwest region                              0.014330                
7.2%

Southern region                             0.012745                
6.4%

Western region                              0.016637                
8.3%

Hispanics                                   0.014982                
7.5%

Non-hispanic whites                         0.014673                
7.3%

Non-hispanic blacks                         0.011327                
5.7%

Non-hisp/non-white/non-black                0.018905                
9.5%

All infants (< 1 year)                      0.008784                
4.4%

Nursing infants                             0.003649                
1.8%

Non-nursing infants                         0.010733                
5.4%

Children 1-6  yrs                           0.020196               
10.1%

Children 7-12 yrs                           0.014665                
7.3%

Females 13-19 (not preg or nursing)         0.011572                
5.8%

Females 20+ (not preg or nursing)           0.014829                
7.4%

Females 13-50 yrs                           0.014455                
7.2%

Females 13+ (preg/not nursing)              0.012403                
6.2%

Females 13+ (nursing)                       0.016402                
8.2%

Males 13-19 yrs                             0.011618                
5.8%

Males 20+ yrs                               0.013551                
6.8%

Seniors 55+                                 0.013857                
6.9%

Children 1-2 yrs                            0.022354               
11.2%

Children 3-5 yrs                            0.019967               
10.0%

Children 6-12 yrs                           0.014955                
7.5%

Youth 13-19 yrs                             0.011643                
5.8%

Adults 20-49 yrs                            0.014271                
7.1%

Adults 50+ yrs                              0.014074                
7.0%

Fluopicolide	Dietary Exposure and Risk Assessment	DP Number: 349721	

PC Code: 027412	

________________________________________________________________________
______________

 PAGE   

Page   PAGE  1  of   NUMPAGES  21 

 

