UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON D.C., 20460

MEMORANDUM	Date:  September 12, 2006

SUBJECT:	Environmental Fate and Ecological Risk Assessment Chapter (DP
Barcode D310733) in Support of Phase I of the Reregistration Eligibility
Decision on Antimycin A (PC Code 006314)

FROM:	Dirk Young, Ph.D., Environmental Engineer

		Thomas Steeger, Ph.D., Senior Biologist

		Environmental Risk Branch IV

Environmental Fate and Effects Division (7507C)

		Office of Pesticide Programs		

		

THROUGH:	Elizabeth Behl, Branch Chief

		Environmental Risk Branch IV

		Environmental Fate and Effects Division (7507C)

		Office of Pesticide Programs

		

TO:		Lance Wormell, Chemical Review Manager

		Dirk Helder, Risk Manager

		Special Review and Reregistration Division (7508C)

Office of Pesticide Programs

The Environmental Fate and Effects Division (EFED) has completed the
draft environmental fate and ecological risk assessment chapter (DP
Barcode D310733) in support of Phase I of the reregistration eligibility
decision on antimycin A (PC Code 006314).  Conclusions regarding the
environmental fate, ecological effects and ecological risks associated
with the current uses of antimycin A can be found in the executive
summary of the attached document.  EFED recommends that application of
antimycin directly to water only be made through close adherence to
established standard operating procedures intended to limit the extent
to which antimycin can move outside of treatment areas.

L.  This is a rough approximation of the maximum rate since the label
was not specific.  This rate is based on the use closure memo dated
October 26, 2005.  

Data Gaps

, there are no data to identify the reaction products.     SEQ CHAPTER
\h \r 1  Although environmental fate data gaps have been identified,
efforts are underway by the U. S. Geological Survey, the EPA Office of
Research and Development and the Office of Pesticide Programs’
Biologic and Economic Assessment Division laboratories to address some
of the uncertainties regarding analytical method development and
potential routes of degradation.

Most of the ecological effects data gaps result from uncertainties
surrounding potential ecological risks associated with the chronic
effects of antimycin in aquatic animals (Guideline §72-4) and
terrestrial animals (avian Guideline §71-4 and mammalian Guideline
§83-4).  Additionally, there are no data to evaluate the toxicity of
antimycin to aquatic (Guideline §123-2) or terrestrial plants
(Guideline §123-1).  These data are important in assessing direct and
indirect risks to Federally-listed endangered and/or threatened species.

Labeling Recommendations

	According to the Label Review Manual, the following label statements
are recommended:

  SEQ CHAPTER \h \r 1 Non-Target Organism Statements

 ≤100 mg/kg: 

"This pesticide is toxic to mammals." 

	The following statement is required because the pesticide is intended
for outdoor use and contains an active ingredient with a fish acute LC50
and an aquatic invertebrate EC50 ≤1 ppm:

"This pesticide is toxic to fish, aquatic invertebrates, oysters and
shrimp.”

  SEQ CHAPTER \h \r 1 

Table A1. Environmental Fate and Transport Data Requirements for
Antimycin A

Guideline #	Data Requirement	MRID / ACC # 

		Study Classification	Are Data Adequate for Risk Assessment?

161-1	835.2120	Hydrolysis	MRID 46023101	Supplemental	YES

161-2	835.2240	Photodegradation in Water	Waived

161-3	835.2410	Photodegradation on Soil	Waived

161-4	835.2370	Photodegradation in Air	Waived

162-1	835.4100	Aerobic Soil Metabolism	Waived

162-2	835.4200	Anaerobic Soil Metabolism	Waived



162-3	835.4400	Anaerobic  Aquatic Metabolism



	162-4	835.4300	Aerobic Aquatic Metabolism	458959-01	Supplemental	YES

163-1	835.1240

835.1230	Leaching-Adsorption/Desorption	Waived

163-2	835.1410	Laboratory Volatility	Waived

163-3	835.8100	Field Volatility	Waived

164-1	835.6100	Terrestrial Field Dissipation	Waived

164-2	835.6200	Aquatic Field Dissipation	No data submitted

164-3	835.6300	Forestry Dissipation	No data submitted

165-4	850.1730	Accumulation in Fish	In Reserve

165-5	None	Accumulation-Aquatic, Non-Target	Waived

166-1	835.71	Small Scale Prospective Groundwater	Waived

166-2	None	Small Scale Retrospective Ground Water	Waived

166-3	None	Large Scale Retrospective Ground Water	Waived





Table A2.  Ecological Effects Data Requirements for Antimycin A.

Guideline # and Data Requirement	Species 	Test Materiala

(% a.i.)	MRID/ACC#	Study Classification	Are Data Adequate for Risk
Assessment?

Avian and Mammalian Studies:

71-1, Acute 

Avian Oral, Quail/Duck	Mallard duck	NS	135924	Supplemental	YES

	Bobwhite quail	NS	135924	Supplemental	YES

71-2, Acute Avian Diet, Quail/Duck	

No Data Submitted

	71-4, Avian Reproduction, Quail/Duck

No Data Submitted

	81-1, Acute Mammalian Oral LD50	Rat





83-1, Chronic Tox Rodent	Rat	No Data Submitted

	Freshwater Fish Studies:

72-1, Acute Freshwater Fish Toxicity	Bluegill sunfish

Green sunfish

Rainbow trout

Cutthroat trout

Coho salmon

Lake trout

Goldfish

Fathead minnow

Black bullhead

Channel catfish

Mosquito fish

Largemouth bass

Yellow perch

White crappie

Paddlefish

	95.5%

	400980-01	Supplemental	YES

72-4(a), Early Life-Stage Fish

No Data Submitted

	72-5 Life Cycle Fish

No Data Submitted 

	Freshwater Invertebrate Studies:

72-2(a), Acute Freshwater Invertebrate Toxicity	Waterflea

Scud

Isopod	95.5%	400980-01	Supplemental	YES

72-4(b), Life 

Cycle Aquatic Invertebrate

No Data Submitted

	Estuarine/Marine Fish Studies:

72-3, Acute Estuarine/Marine Tox Fish LC50	Spot	95.5%	400980-01
Supplemental	YES

72-3, Acute Estuarine/Marine Tox Invertebrate LC50





	72-4, Chronic Estuarine/Marine Tox Fish NOAEC

No Data Submitted









Estuarine/Marine Aquatic Invertebrates:

72-3(b), Acute Estuarine/Marine Mollusk

No data submitted	NO

72-3(c), Acute Estuarine/Marine Shrimp	Pink Shrimp	95.5%	400980-01
Supplemental	YES

72-4, Chronic Estuarine/Marine Shrimp

No data submitted	NO

Terrestrial and Aquatic Plants:

122-1, Seedling Emergence and Vegetative Vigor

No Data Submitted	NO

122-2, Aquatic Plant Growth (Tier I)

No Data Submitted	NO

123-1, Seed Germ,  Seedling Emergence, Vegetative Vigor 

(Tier II)

No Data Submitted	NO

123-2 Aquatic Plant Growth (Tier II)

No Data Submitted	NO

Terrestrial Insect Testing:

141-2, Honey Bee Residue on Foliage	

		No Data Submitted

	NO

144-1, Honey Bee Acute Contact

No Data Submitted	NO

a TGAI = technical grade active ingredient; TEP = typical end-use
product; ND = not determined, because purity was not reported or
original study was unavailable.

b Study was classified as supplemental pending upgrade to acceptable. 
The upgrade was denied, but for piscicidal uses EPA did not require a
repeat of the study due to the preponderance of data available.

 PAGE   

 PAGE   2 

BR: Again, use of 25 ppb Fintrol per application seems very high, and
needs to be documented.  Throughout the document, it needs to be clear
if the discussion is about ppb/mg/l of Fintrol or antimycin A.

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at Fintrol is neutralized by potassium permanganate.  This is the same
process used to neutralize rotenone.  The Assessment does reference the
publication by Moore.

