
Page
1
of
3
UNITED
STATES
ENVIRONMENTAL
PROTECTION
AGENCY
WASHINGTON,
D.
C.
20460
OFFICE
OF
PREVENTION,
PESTICIDES
AND
TOXIC
SUBSTANCES
MEMORANDUM
DATE:
03­
AUG­
2006
SUBJECT:
AMENDMENT
TO:
Kresoxim­
Methyl
on
Cucurbit
Vegetables
(
PP#
3E6594).
Health
Effects
Division
(
HED)
Human­
Health
Risk
Assessment.
Date:
26­
JUL­
2006.
DP#:
313836.
PC
Code
129111.
Decision#:
354442.
40
CFR:
180.554.

DP#:
331639.
Decision#:
354442.

FROM:
Sarah
Levy,
Chemist
Registration
Action
Branch
1
(
RAB1)/
HED
(
7509P)

THROUGH:
Felecia
Fort,
Acting
Branch
Chief
and
PV
Shah,
Ph.
D.,
Branch
Senior
Scientist
RAB1/
HED
(
7509P)

TO:
Barbara
Madden/
Dan
Rosenblatt,
PM
Team
05
Registration
Division
(
RD,
7505P)

The
most
recent
human­
health
risk
assessment
for
kresoxim­
methyl
was
completed
on
26­
JUL­
2006
(
Memo,
S.
Levy,
et
al.;
D313836).
Subsequent
to
this
assessment,
the
Environmental
Fate
and
Effects
Division
(
EFED)
submitted
revised
estimated
drinking
water
concentration
(
EDWC)
values
for
residues
of
kresoxim­
methyl
(
electronic
correspondence,
R.
Kashuba
to
S.
Levy,
28­
JUL­
2006;
D330783).
Therefore,
HED
has
revised
the
last
dietary
assessment
(
Memo,
S.
Levy,
03­
AUG­
2006;
D331629)
and
human­
health
risk
assessment
to
include
these
updated
EDWC
values.
These
EDWC
revisions
are
the
only
changes
made
to
the
last
dietary
assessment
and
human­
health
risk
assessment.

The
following
updated
sections
replace
the
corresponding
sections
in
the
26­
JUL­
2006
humanhealth
risk
assessment.
Page
2
of
3
4.2.2.2
Chronic
(
Non­
Cancer)­
Dietary
Exposure
Analysis
Kresoxim­
methyl
chronic
dietary
(
food
+
water)
exposure
estimates
using
the
Dietary
Exposure
Evaluation
Model
software
with
the
Food
Commodity
Intake
Database
(
DEEM­
FCID
 
)
software
are
below
HED's
level
of
concern
for
the
U.
S.
population
and
each
of
the
population
subgroups.
The
1­
in­
10­
year
annual
mean
concentration
value
was
used
to
estimate
water
exposure.
Dietary
exposure
was
estimated
at
0.000382
mg/
kg/
day
for
the
U.
S.
population
(<
1.0%
of
the
chronic
population
adjusted
dose
(
cPAD))
and
0.001139
mg/
kg/
day
(<
1.0%
of
the
cPAD)
for
the
most
highly
exposed
population
subgroup
(
all
infants,
<
1
year
old).
The
estimated
exposures/
risks
from
food
and
water
are
summarized
in
Table
4.2.2.2.1
for
all
populations.

Table
4.2.2.2.1.
Summary
of
Chronic
(
Non­
Cancer)­
Dietary
Exposure
and
Risk
for
Kresoxim­
methyl.
1
Population
Subgroup
cPAD
(
mg/
kg/
day)
Exposure
(
mg/
kg/
day
%
cPAD
General
U.
S.
Population
0.000382
<
1.0
All
Infants
(<
1
year
old)
0.001139
<
1.0
Children
1­
2
years
old
0.000651
<
1.0
Children
3­
5
years
old
0.000608
<
1.0
Children
6­
12
years
old
0.000396
<
1.0
Youth
13­
19
years
old
0.000276
<
1.0
Adults
20­
49
years
old
0.000340
<
1.0
Adults
50+
years
old
0.000377
<
1.0
Females
13­
49
years
old
0.36
0.000344
<
1.0
1The
population
subgroup
with
the
highest
estimated
chronic
dietary
(
food
+
drinking
water)
exposure
and
risk
is
indicated
by
bold
text.

4.2.2.3
Chronic
(
Cancer)­
Dietary
Exposure
Analysis
The
estimated
exposure
of
the
general
U.
S.
population
to
kresoxim­
methyl
is
0.000234
mg/
kg/
day.
Applying
the
Q1*
of
0.0029
(
mg/
kg/
day)­
1
to
the
exposure
value
results
in
a
lifetime
cancer
risk
estimate
of
6.80
x
10­
7.
HED
considers
cancer
risk
estimates
between
1
x
10­
6
and
3
x
10­
6
to
fall
within
the
acceptable
range
of
cancer
risk
(
i.
e.,
less
than
10­
6);
therefore,
the
cancer
risk
estimate
for
kresoxim­
methyl
is
below
HED's
level
of
concern.

4.3
Water
Exposure/
Risk
Pathway
The
residues
of
concern
in
drinking
water
are
kresoxim­
methyl
and
its
major
acid
degradate/
metabolite,
BF
490­
1
((
E)­
2­[
2­(
2­
methylphenoxy)
methyl]­
phenyl­
2­
(
methoxyimido)
acetic
acid).
Based
on
the
environmental
fate
properties
of
kresoxim­
methyl,
EFED
believes
that
the
parent
compound
is
relatively
short­
lived
and,
therefore,
unlikely
to
leach
to
ground
water
or
move
offsite
to
surface
water
in
significant
concentrations.
However,
BF
490­
1
has
the
physical/
chemical
characteristics
of
pesticides
that
are
known
to
leach
to
ground
water
or
to
move
offsite
to
surface
water
and
may
pose
a
risk
of
ground
or
surface
water
contamination,
particularly
when
kresoxim­
methyl
is
applied
to
fields
with
one
or
more
of
the
following
characteristics:
alkaline
soils,
low
organic
matter,
high
sand
content,
shallow
groundwater
table
or
nearby
bodies
of
water.
Page
3
of
3
There
are
no
drinking
water
monitoring
data
available
for
kresoxim­
methyl
or
its
metabolite.
Estimated
ground
water
and
surface
water
concentrations
were
generated
using
the
Screening
Concentration
in
Ground
Water
(
SCI­
GROW)
and
Pesticide
Root
Zone
Model/
Exposure
Analysis
Modeling
System
(
PRZM/
EXAMS)
models,
respectively.
EDWCs
were
provided
for
both
kresoxim­
methyl
and
BF
490­
1.
The
PRZM­
EXAMS
surface
water
modeling
estimates
were
based
on
a
Florida
cucurbits
crop
scenario.
The
modeled
EDWCs
for
ground
and
surface
water
are
summarized
in
Table
4.3.1(
electronic
correspondence,
R.
Kashuba
to
S.
Levy,
28­
JUL­
2006;
D330783).

Table
4.3.1.
Ground
and
Surface
Water
EDWCs
for
Kresoxim­
methyl
and
BF
490­
1.
Surface
Water
Ground
Water
Concentration
(
ppb)
1­
in
10­
Year
Annual
Mean
Concentration
(
ppb)
30­
Year
Mean
Concentration
(
ppb)
Kresoxim­
methyl
0.000385
0.11
0.07
BF
490­
1
6.27
14.8
7.81
Combined
Residues
of
Concern
6.27
14.91
7.88
cc:
S.
Levy
(
RAB1)
RDI:
F.
Fort
(
03­
AUG­
2006);
P.
V.
Shah
(
03­
AUG­
2006)
S.
Levy:
S­
10953:
PY1:(
703)
305­
0783:
7509P:
RAB1
