  UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

					WASHINGTON, D.C.  20460

OFFICE OF              

PREVENTION, PESTICIDES

AND TOXIC SUBSTANCES 

  SEQ CHAPTER \h \r 1 

01/31/2006

MEMORANDUM

SUBJECT:	Cacodylic Acid / Sodium Cacodylate.  Product Chemistry Chapter
for the 				Reregistration Eligibility Decision.  

DP Barcode:  D325973

		PC Code(s):   012501 and 012502

		Chemical Class: Organo Arsenical

FROM:	P. Yvonne Barnes, Chemist

Reregistration Branch 2

Health Effects Division [7509C]

THRU:	Alan Nielsen, Branch Senior Scientist

Reregistration Branch 2

Health Effects Division [7509C]

TO:		Diana Locke, Ph.D., Risk Assessor

Reregistration Branch 2

Health Effects Division [7509C]

  SEQ CHAPTER \h \r 1 The summary analytical chemistry and residue data
document was originally prepared under contract by Dynamac Corporation,
The Dynamac Building 2275 Research Boulevard Rockville, MD 20850-3268.



	CACODYLIC ACID AND SALT

	REREGISTRATION ELIGIBILITY DECISION:

	PRODUCT CHEMISTRY CONSIDERATIONS

	PC Codes 012501 and 012502; Case No. 2080

DESCRIPTION OF CHEMICAL

Cacodylic acid [dimethylarsinic acid] and its sodium salt, sodium
cacodylate, are nonselective herbicides used in combination, primarily
as a cotton defoliant.

Empirical Formula:		C2H7AsO2			C2H6AsNaO2

Molecular Weight:		137.99         		159.99

CAS Registry No.:		75-60-5        		124-65-2

PC Code:				012501         		012502

IDENTIFICATION OF ACTIVE INGREDIENT

Cacodylic acid is a white crystalline solid with a melting point of
192-194 ºC, density of 1.10 g/mL, and octanol/water partition
coefficient (Pow) of <0.028 at 25 °C.  Cacodylic acid is soluble in
water (102 g/100 mL at 25 °C), and is very soluble in alcohol, less
soluble in acetic acid, and practically insoluble in ether.  Cacodylic
acid is hygroscopic.

Sodium cacodylate is a white solid with a melting point of 77-79.5 ºC
and density of 0.80 g/mL.  Sodium cacodylate is soluble in methanol at
91.3 g/100 mL and is practically insoluble in hexane at <1.09 x 10-5 at
25 °C.  This salt is soluble in water at 82 g/100 g.

MANUFACTURING-USE PRODUCTS

The MAA Research Task Force proposes that all manufacturing-use and
end-use products will conform to the MAATF master labels for organo
arsenicals when finalized. Because cacodylic acid is a list B chemical,
only the cacodylic acid technical grade active ingredient [TGAI] and
sodium cacodylate TGAI are subject to a reregistration eligibility
decision.

REGULATORY BACKGROUND

The cacodylic acid and its sodium salt Phase 4 Review dated 03/06/1991
by L. Cheng determined that additional data were required, concerning
starting materials and the production process, discussion of formation
of impurities, preliminary analysis, certified limits, enforcement
methods, stability, and solubility (OPPTS 830.1600, 1620, 1670, 1700,
1750, 1800, 6313, and 7840) for cacodylic acid, and that additional data
were required for all guidelines except product identity (OPPTS
830.1550) for sodium cacodylate; product chemistry data submissions for
remaining data requirements were determined to be acceptable for Phase 5
review.  The Agency determined in the Phase 4 Review and in subsequent
memoranda that a TGAI containing a mixture of cacodylic acid and sodium
cacodylate would be acceptable to fulfill preliminary analysis data
requirements, but that separate acid and salt test substances would be
required to fulfill data requirements for physical/chemical properties.

The current status of the product chemistry data requirements for the
cacodylic acid and sodium cacodylate TGAIs is presented in the attached
data summary tables.  Refer to these tables for a listing of the
outstanding product chemistry data requirements. 

CONCLUSIONS

Eleven product chemistry data requirements remain unfulfilled for the
Luxembourg-Pamol cacodylic acid (OPPTS 830.1550,1600, 1620, 1650, 1670,
1750, 1800, 1900, 6313, 7050 and 7950) and ten product chemistry data
requirements remain unfulfilled for the Luxembourg-Pamol sodium
cacodylate (OPPTS 830.1550,1600, 1620, 1650, 1670, 1750, 1800, 1900,
7050 and 7950) TGAIs; additional data are required.  Provided that the
registrant submits the data required in the attached data summary tables
for the cacodylic acid and sodium cacodylate TGAIs, and either certifies
that the suppliers of beginning materials and the manufacturing
processes have not changed since the last comprehensive product
chemistry review or submits new complete updated product chemistry data
packages, HED has no objections to the reregistration of cacodylic acid
and sodium cacodylate with respect to product chemistry data
requirements.

AGENCY MEMORANDA CITED IN THIS DOCUMENT

CBRS No(s):	8865

DP Barcode(s):	D170691

Subject:		CCI Inc.:  Response to the cacodylic Acid Phase IV Review: 
Product Chemistry Questions.

From:		R. Perfetti

To:			B. Crompton/B. Briscoe

Dated:		12/18/1991

MRID(s):		None

CBRS No(s):	10279 and 10340

DP Barcode(s):	D180910 and D181087

Subject:		Cacodylic Acid and Sodium Cacodylate Reregistration:  a List B
Chemical (Chemical No.: 012501 and 012502; Case No. 2080). 
Luxembourg-Pamol:  Response to the Cacodylic Acid and Sodium Cacodylate
Phase 4 Review (dated 3/11/91) Product Chemistry (63 Series) Data
Requirements.

From:		F. Toghrol

To:			B. Briscoe/B. Crompton

Dated:		12/23/1992

MRID(s):		42397101 and 42403501

CBRS No(s):	10620, 10621, and 10634

DP Barcode(s):	D182857, D182869, and D182972

Subject:		Cacodylic Acid and Sodium Cacodylate Reregistration:  a List B
Chemical (Chemical No.: 012501 and 012502; Case No. 2080). 
Luxembourg-Pamol:  Response to the Cacodylic Acid and Sodium Cacodylate
Phase 4 Review (dated 3/11/91) Product Chemistry (63 Series) Data
Requirements.

From:		F. Toghrol

To:			B. Briscoe/B. Crompton

Dated:		03/01/1993

MRID(s):		40957801 and 42473801

CBRS No(s):	11236

DP Barcode(s):	D187059

Subject:		Cacodylic Acid and Sodium Cacodylate Reregistration:  List B
Chemical (Chemical No.: 012501 and 012502; Case No. 2080). 
Luxembourg-Pamol:  Response to the Cacodylic Acid and Sodium Cacodylate
Phase 4 Review (dated 03/11/1991) Product Chemistry Data Requirements.

From:		F. Toghrol

To:			B. Briscoe/R. Kendall

Dated:		04/23/1993

MRID(s):		42614501

CBRS No(s):	12828

DP Barcode(s):	D196662

Subject:		Cacodylic Acid and Sodium Cacodylate Reregistration:  List B
Chemical Nos. 012501 and 012502; Case No. 2080).  Luxembourg-Pamol: 
Response to the Cacodylic Acid and Sodium Cacodylate Review (dated
4/20/93) Product Chemistry Data Requirements.

From:		F. Toghrol

To:			B. Briscoe/R. Kendall

Dated:		12/17/1993

MRID(s):		42614501

PRODUCT CHEMISTRY CITATIONS

Bibliographic citations include only MRIDs containing data which fulfill
data requirements. 

References (cited):

40957801 Duescher, R. (1988) Determination of Stability: Laboratory
Project  ID HLA 6001-332.  Unpublished study prepared by Hazleton
Laboratories America, Inc.  18 p.

40957813 Bellet, E. (1988) Product Chemistry for 3.25 Cacodylate. 
Unpublished study prepared by Luxembourg-Pamol, Inc.  8 p. 

41608302 Bellet, E. (1990) Cacodylate 3.25: Analytical Methods. 
Unpublished study prepared by Luxembourg Industries, Ltd.  4 p. 

42397101 Pesselman, R. (1992) Series 63 Product Chemistry Determinations
 of Cacodylic Acid (Melting Point, Solubility, Dissociation  Constant,
and Octanol/Water Partition Coefficient): Final Report: Lab Project
Number: HWI 6366-107.  Unpublished study prepared  by Hazleton
Wisconsin, Inc.  59 p. 

42403501 Pesselman, R. (1992) Series 63 Product Chemistry Determinations
 of Sodium Cacodylate (Melting Point, Solubility, Dissociation Constant,
and Stability): Final Report: Lab Project Number: HWI  6366-106. 
Unpublished study prepared by Hazleton Wisconsin, Inc.  54p. 

42473801 Bellet, E. (1992) Cacodylate 3.25: Physical and Chemical
Characteristics.  Unpublished study prepared by Chemical Consultants
International, Inc.  5 p.

42614501 Shvo, Y. comp. (1992) Cacodylic Acid and Sodium Cacodylate: 
Preliminary Analysis and Certification of Limits: Cacodylate 3.25. 
Unpublished compilation prepared by Luxembourg Industries (Pamol), Ltd. 
8 p.  

92015001 Bellet, E. (1990) Luxembourg-Pamol Inc. U.S.A. Phase 3 Summary
of MRID 40957813.  Cacodylate 3.25: Product Identity and Composition. 
11 p. 

Case No. 2080

PC Code 012501

Case Name:  Cacodylic Acid, and Salts

Registrant: Luxembourg-Pamol, Inc.

Product(s):  Cacodylic acid TGAI

	PRODUCT CHEMISTRY DATA SUMMARY

Table 1.      SEQ CHAPTER \h \r 1 Product Chemistry Data Summary for
Cacodylic Acid 

OPPTS Guideline Numbers	Data Requirements: Cacodylic Acid [TGAI]

PC code: 012501; CAS Number: 75-60-5

	Master Record Identification [MRID]  or Reference	

Data Requirements Fulfilled	

Results

 or

 *Data Gap

830.1550 	Product Identity and Composition  

No	* Data Gap

830.1600	Description of Materials Used to Produce the Product

No	* Data Gap

830.1620 	Description of Production Process

No	* Data Gap

830.1650 	Description of Formulation Process

No	* Data Gap

830.1670 	Discussion of Formation of Impurities

No	* Data Gap

830.1700 	Preliminary Analysis	41608302, 42614501	Yes

	830.1750 	Certified Limits

No	* Data Gap

830.1800 	Enforcement Analytical Method

No	* Data Gap

830.1900 	Submittal of Samples

No 	* Data Gap

830.6302 	Color	40957813,

42473801	Yes	White

830.6303 	Physical State	40957813,

42473801	Yes	Crystalline solid

830.6304 	Odor	40957813, 42473801	Yes	No odor

830.6313  	Stability to normal and elevated temperatures, metals and
metal ions

No	*Data Gap

830.7000 	pH	40957813, 42473801	Yes

	830.7050  	UV/VIS absorption

No	* Data Gap

830.7200 	Melting Point/Melting Range	42397101	Yes	 192 ºC – 194 ºC 
       

830.7220 	Boiling Point/Boiling Point Range	See Guideline  830.7200

830.7300 	Density/Relative Density/Bulk Density	40957813,

42473801	Yes	1.10 g / mL  

830.7370 	Dissociation  Constant	42403501	Yes	pKa = 6.17 at 25 ºC

830.7550 	Partition coefficient (n-octanol /water) shake flask method
42397101	Yes	K o/w = < 0.028  at 25ºC

830.7560	Partition coefficient (n-octanol /water) generator column
method	See guideline 830.7550



830.7570	Partition coefficient (n-octanol /water) estimation by liquid
chromatography

	830.7840	Water Solubility: Column Elution Method; Shake Flask Method
42397101	Yes	 102 g / 100 mL 

830.7860 	Water solubility generator column method 	See guideline
830.7840

830.7950 	Vapor pressure

No 	* Data Gap

Case No. 2080

PC Code 012502

Case Name:  Cacodylic Acid, and Salts

Registrant: Luxembourg-Pamol, Inc.

Product(s):  Sodium Cacodylate TGAI

	PRODUCT CHEMISTRY DATA SUMMARY

Table 2.    SEQ CHAPTER \h \r 1 Product Chemistry Data Summary for
Sodium Cacodylate

OPPTS Guideline Numbers	Data Requirements

Sodium Cacodylate [TGAI]

PC Code: 012502

CAS No.: 124-65-2	Master Record Identification [MRID]  or Reference	

Data Requirements Fulfilled	

Results

 or

 *Data Gap

830.1550 	Product Identity and Composition  

No	* Data Gap

830.1600 

	Description of Materials Used to Produce the Product

No	* Data Gap

830.1620 	Description of Production Process

No	* Data Gap

830.1650 	Description of Formulation Process

No	* Data Gap

830.1670 	Discussion of Formation of Impurities

No	* Data Gap

830.1700 	Preliminary Analysis	41608302, 42614501	Yes

	830.1750 	Certified Limits

No	* Data Gap

830.1800 	Enforcement Analytical Method

No	* Data Gap

830.1900 	Submittal of Samples

No 	* Data Gap

830.6302 	Color	40957813,

42473801	Yes	White

830.6303 	Physical State	40957813,

42473801	Yes	Crystalline solid

830.6304 	Odor	40957813, 42473801	Yes	No odor

830.6313  	Stability to normal and elevated temperatures, metals and
metal ions	42403501	Yes	Stable 

830.7000 	pH	42473801	Yes

	830.7050  	UV/VIS absorption

No	* Data Gap

830.7200 	Melting Point/Melting Range	42403501	Yes	   77 oC –    79.5
oC

830.7220 	Boiling Point/Boiling Point Range	Not Applicable

830.7300 	Density/Relative Density/Bulk Density	40957813

42473801	Yes	1.10 g / mL  

830.7370 	Dissociation  Constant	42403501	Yes	  pKa = 6.21 at 25 oC

830.7550 	Partition coefficient (n-octanol /water) shake flask method

Not Applicable	CRBS 8865, D170691 12/12/1991 A. Perfetti

830.7560	Partition coefficient (n-octanol /water) generator column
method	

See guideline 830.7550



830.7570	Partition coefficient (n-octanol /water) estimation by liquid
chromatography

	830.7840	Water Solubility: Column Elution Method; Shake Flask Method
42397101	Yes	82 g / 100 mL

830.7860 	Water solubility generator column method 	See guideline
830.7840

830.7950 	Vapor pressure

No	* Data Gap



 

 PAGE   

 PAGE   1 

