	

	UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

	WASHINGTON, D.C.  20460

OFFICE OF PREVENTION, PESTICIDES AND

TOXIC SUBSTANCES

	August 24, 2006

MEMORANDUM

				

SUBJECT:	Review of Hexythiazox Incident Reports

		DP Barcode 333939, Chemical #128849

FROM:	Monica S. Hawkins, M.P.H., Environmental Health Scientist

		Chemistry and Exposure Branch

		Health Effects Division (7509P)

		Hans Allender, Ph.D., Statistician

		Chemistry and Exposure Branch

		Health Effects Division (7509P)

THRU:	David J. Miller, Chief

		Chemistry and Exposure Branch 

		Health Effects Division (7509P)

TO:		Kennan Garvey

		Special Review and Reregistration Division (7508P)

BACKGROUND

			

	The following data bases have been consulted for the poisoning incident
data on the active ingredient Hexythiazox (128849):

1)  OPP Incident Data System (IDS) - reports of incidents from various
sources, including registrants, other federal and state health and
environmental agencies and individual consumers, submitted to OPP since
1992.  Reports submitted to the Incident Data System represent anecdotal
reports or allegations only, unless otherwise stated.  Typically no
conclusions can be drawn implicating the pesticide as a cause of any of
the reported health effects.  Nevertheless, sometimes with enough cases
and/or documentation risk mitigation measures may be suggested.

2)  Poison Control Centers - as the result of a data purchase by EPA,
OPP received Poison Control Center data covering the years 1993 through
2003 for all pesticides.  Most of the national Poison Control Centers
(PCCs) participate in a national data collection system, the Toxic
Exposure Surveillance System which obtains data from about 65-70 centers
at hospitals and universities.  PCCs provide telephone consultation for
individuals and health care providers on suspected poisonings, involving
drugs, household products, pesticides, etc.

3)  California Department of Pesticide Regulation  - California has
collected uniform data on suspected pesticide poisonings since 1982. 
Physicians are required, by statute, to report to their local health
officer all occurrences of illness suspected of being related to
exposure to pesticides.  The majority of the incidents involve workers. 
Information on exposure (worker activity), type of illness (systemic,
eye, skin, eye/skin and respiratory), likelihood of a causal
relationship, and number of days off work and in the hospital are
provided.

4)  National Pesticide Information Center (NPIC) - NPIC is a toll-free
information service supported by OPP.  A ranking of the top 200 active
ingredients for which telephone calls were received during calendar
years 1984-1991, inclusive has been prepared.  The total number of calls
was tabulated for the categories human incidents, animal incidents,
calls for information, and others.

5) National Institute of Occupational Safety and Health’s Sentinel
Event Notification System for Occupational Risks (NIOSH SENSOR) performs
standardized surveillance in nine states from 1998 through 2003.  States
included in this reporting system are Arizona, California, Florida,
Louisiana, Michigan, New York, Oregon, Texas, and Washington.  Reporting
varies from state to state because of the differing degrees of
cooperation from different sources of reporting (e.g., workers
compensation, Poison Control Centers, emergency departments and
hospitals, enforcement investigations, private physicians, etc.). 
Therefore, these reports should not be characterized as estimating the
total magnitude of poisoning.  The focus is on occupationally-related
cases not residential or other non-occupational exposures.   However,
the information collected on each case is standardized and categorized
according to the certainty of the information collected and the severity
of the case.

HEXYTHIAZOX REVIEW

I. Incident Data System

	There were no reports for hexythiazox in the Incident Data System.

                                                                        
                                              

II. Poison Control Center Data - 1993 through 2003

	Results for the years 1993 through 2003 of the Poison Control Center
show a total of one exposure to hexythiazox.  Cases involving exposures
to multiple products are excluded. The one exposure was in the non
occupational class and the case was followed. This was too few cases to
warrant detailed analysis. The case reported involved a moderate outcome
that could not be attributed to the compound. Despite the small sample,
the Poison Control Center data for this compound suggests that exposure
to hexythiazox is unlikely to result in serious health effects.

	

III.  NIOSH SENSOR

	

	Out of 5,899 reported cases from 1998 to 2003, none involved
hexythiazox.

IV. Conclusion

	

	There was only 1 report of an ill effect from exposure to hexythiazox
in the available data bases.

V.  Recommendations

								

	No recommendations are made based on the limited information available.


cc:	Hexythiazox file (128849)

	David J. Miller (7509P)

	

									

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