	

	UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

	WASHINGTON, D.C.  20460

OFFICE OF PREVENTION, PESTICIDES AND TOXIC SUBSTANCES

	February 21, 2007

MEMORANDUM

				

SUBJECT:	Review of Cyromazine Incident Reports

		DP Barcode D335283, Chemical #031301

FROM:	Monica Hawkins, M.P.H., Environmental Health Scientist

		Chemistry and Exposure Branch

		Health Effects Division (7509P)

		Hans Allender, Ph.D., Statistician

		Chemistry and Exposure Branch

		Health Effects Division (7509P)

THRU:	David J. Miller, Chief

		Chemistry and Exposure Branch 

		Health Effects Division (7509P)

TO:		James Parker, Chemical Review Manager

		Special Review and Registration Division (7508P)

BACKGROUND

			

	The following data bases have been consulted for the poisoning incident
data on the active ingredient Cyromazine (031301):

1)  OPP Incident Data System (IDS) - reports of incidents from various
sources, including registrants, other federal and state health and
environmental agencies and individual consumers, submitted to OPP since
1992.  Reports submitted to the Incident Data System represent anecdotal
reports or allegations only, unless otherwise stated.  Typically no
conclusions can be drawn implicating the pesticide as a cause of any of
the reported health effects.  Nevertheless, sometimes with enough cases
and/or documentation risk mitigation measures may be suggested.

2)  Poison Control Centers - as the result of a data purchase by EPA,
OPP received Poison Control Center data covering the years 1993 through
2003 for all pesticides.  Most of the national Poison Control Centers
(PCCs) participate in a national data collection system, the Toxic
Exposure Surveillance System which obtains data from about 65-70 centers
at hospitals and universities.  PCCs provide telephone consultation for
individuals and health care providers on suspected poisonings, involving
drugs, household products, pesticides, etc.

3)  National Institute of Occupational Safety and Health’s Sentinel
Event Notification System for Occupational Risks (NIOSH SENSOR) performs
standardized surveillance in nine states from 1998 through 2003.  States
included in this reporting system are Arizona, California, Florida,
Louisiana, Michigan, New York, Oregon, Texas, and Washington.  Reporting
varies from state to state because of the differing degrees of
cooperation from different sources of reporting (e.g., workers
compensation, Poison Control Centers, emergency departments and
hospitals, enforcement investigations, private physicians, etc.). 
Therefore, these reports should not be characterized as estimating the
total magnitude of poisoning.  The focus is on occupationally-related
cases not residential or other non-occupational exposures.   However,
the information collected on each case is standardized and categorized
according to the certainty of the information collected and the severity
of the case.

CYROMAZINE REVIEW

I. Incident Data System

	There were no reports located in the Incident Data System.

                                                                        
                                                

II. Poison Control Center Data - 1993 through 2005

  SEQ CHAPTER \h \r 1 	Results for the years 1993 through 2005 on the
Poison Control Center show only one case reported in the occupational
class for Cyromazine. The individual exposed presented mild symptoms but
did not visit a HCF; the symptoms are unknown.  

III. NIOSH SENSOR

	

	Out of 5,899 reported cases from 1998 to 2003, there is no case
reported in the SENSOR database involving Cyromazine.

IV. Conclusion

	

	There were almost no reports of ill effects from exposure to Cyromazine
in the available data bases.

V.  Recommendations

								

	No recommendations are made based on the limited information available.


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