1
of
44
UNITED
STATES
ENVIRONMENTAL
PROTECTION
AGENCY
WASHINGTON,
D.
C.
20460
OFFICE
OF
PREVENTION,
PESTICIDES,
AND
TOXIC
SUBSTANCES
MEMORANDUM
Date:
November
17,
2005
Subject:
Triadimenol.
Summary
of
Analytical
Chemistry
and
Residue
Data
for
the
Tolerance
Reassessment
Eligibility
Decision
(
TRED)
Document.

DP
Barcode:
D314891
PC
Code:
127201
40
CFR
§
:
180.450
Chemical
Class:
Azole
From:
Samuel
Ary,
Chemist
Reregistration
Branch
II
Health
Effects
Division
(
7509C)

Through:
Yvonne
Barnes,
Chemist
Reregistration
Branch
II
Health
Effects
Division
(
7509C)

Chemistry
Science
Advisory
Council
Health
Effects
Division
(
7509C)

Alan
Nielsen,
Branch
Senior
Scientist
Reregistration
Branch
II
Health
Effects
Division
(
7509C)

To:
Richard
Griffin,
Risk
Assessor
Christina
Jarvis,
Risk
Assessor
Reregistration
Branch
II
Health
Effects
Division
(
7509C)

John
Pates,
Chemical
Review
Manager
Reregistration
Branch
I
Special
Review
and
Reregistration
Division
(
7508C)
Triadimenol
Summary
Analytical
Chemistry
and
Residue
Data
­
TRED
DP
Barcode:
314891
2
of
44
Executive
Summary
Triadimenol,
$­(
4­
chlorophenoxy)­"­(
1,1­
dimethylethyl)­
1H­
1,2,4­
triazole­
1­
ethanol,
is
a
systemic
fungicide
registered
for
use
in
the
United
States
as
a
seed
treatment
for
barley,
corn,
cotton,
oats,
rye,
sorghum,
and
wheat.
Additionally,
an
import
tolerance
on
bananas
has
been
established.
Triadimenol
end­
use
products
are
marketed
in
the
U.
S.
under
the
trade
name
Baytan
®
.
The
reregistration
of
triadimenol
is
being
supported
by
Bayer
CropScience
(
Bayer),
the
basic
producer.
The
triadimenol
formulations
registered
for
food/
feed
uses
include
wettable
powder
(
WP),
flowable
concentrate
(
FlC),
emulsifiable
concentrate
(
EC),
and
soluble
concentrate
(
SC)
formulations.

Tolerances
are
established
for
residues
of
triadimenol
and
1­(
4­
chlorophenoxy)­
3,3­
dimethyl­
3­
hydroxymethyl­
1­(
1H­
1,2,4­
triazol­
1­
yl)­
2­
butanol
(
KWG
1342;
calculated
as
triadimenol)
in/
on
various
plant
commodities
[
40
CFR
§
180.450(
a)].
The
established
tolerances
for
plant
commodities
range
from
0.01
ppm
(
sorghum
grain
and
fodder)
to
2.5
ppm
(
green
forage
of
oats,
rye,
and
wheat).
Tolerances
are
established
for
residues
of
triadimenol
and
its
metabolites
containing
the
chlorophenoxy
moiety
(
calculated
as
triadimenol)
in/
on
livestock
commodities
at
0.01
ppm
(
milk,
and
poultry
commodities)
and
0.1
ppm
(
fat,
meat,
and
meat
byproducts
of
cattle,
goats,
hogs,
horses,
and
sheep).

Triadimenol
and
its
butanediol
metabolite
(
KWG
1342)
are
also
regulated
as
metabolites
of
the
fungicide
triadimefon
(
40
CFR
§
180.410).
In
addition,
40
CFR
§
180.3(
d)(
13)
specifies
that
where
tolerances
are
established
for
residues
of
both
1­(
4­
chlorophenoxy)­
3,3­
dimethyl­
1­(
1H­
1,2,4­
triazol­
1­
yl)­
2­
butanone
(
triadimefon)
and
triadimenol
including
its
butanediol
metabolite
in
or
on
the
same
raw
agricultural
commodity
and
its
products
thereof,
the
total
amount
of
such
residues
shall
not
yield
more
residue
than
that
permitted
by
the
higher
of
the
two
tolerances.
Currently,
triadimefon
and
triadimenol
do
not
share
any
uses,
so
40
CFR
§
180.3(
d)(
13)
should
be
deleted.

The
reregistration
requirements
for
plant
metabolism
have
not
been
fulfilled.
No
metabolism
studies
with
triadimenol
have
been
submitted;
however,
metabolism
studies
with
triadimefon
have
been
received
and
reviewed.
The
Health
Effects
Division
(
HED)
has
examined
the
results
of
these
studies
and
determined
that
the
triadimefon
residues
of
concern
in/
on
apples,
grapes,
pears,
pineapples,
and
raspberries
for
tolerance
expression
are
triadimefon
and
triadimenol
and
for
risk
assessment
are
triadimefon,
triadimenol,
KWG
1323
[
1­(
4­
chlorophenoxy)­
3,3­
dimethyl­
3­
hydroxymethyl­
1­(
1H­
1,2,4­
triazol­
1­
yl)­
2­
butanone],
and
KWG
1342
(
S.
Ary,
D314742,
11/
23/
2005).
Of
these
compounds,
triadimenol
and
KWG
1342
are
currently
regulated
for
plant
commodities.

HED
has
determined
that
translation
of
metabolism
data
from
triadimefon
to
triadimenol
is
not
appropriate
for
the
existing
uses
on
cereal
grains
and
cotton.
The
metabolism
studies
with
triadimefon
were
conducted
using
a
foliar
application
and
triadimenol
is
used
only
as
a
seed
treatment.
Additionally,
in
the
submitted
triadimenol
seed
treatment
wheat
study,
residues
in
grain
were
not
identifiable
due
to
the
low
activity
found
in
wheat
grain.
Therefore,
HED
concludes
that
the
nature
of
the
residue
in
cereal
grains
and
cotton
is
not
adequately
understood;
however,
based
on
chemical
structure
and
the
probable
metabolic
pathway
of
triadimenol,
the
residues
of
concern
for
tolerance
expression
and
risk
assessment
are
likely
to
be
triadimenol,
Triadimenol
Summary
Analytical
Chemistry
and
Residue
Data
­
TRED
DP
Barcode:
314891
3
of
44
KWG
1342,
and
KWG
1732
in/
on
cereal
grains
(
barley,
corn,
oats,
rye,
and
wheat)
and
cotton.
Separate
metabolism
studies
with
triazole­
14C
and
phenyl­
14C
labeled
triadimenol
applied
as
a
seed
treatment
to
corn
or
wheat
and
cotton
should
be
conducted
to
confirm
the
residues
of
concern.
The
residues
of
concern
for
tolerance
expression
and
risk
assessment
for
bananas
are
triadimenol
and
KWG
1342.

Additionally,
the
Agency
does
have
concern
about
the
potential
toxicity
of
1,2,4­
triazole
and
two
conjugates,
triazole
alanine
and
triazole
acetic
acid,
which
are
metabolites
common
to
most
of
the
triazole
fungicides.
To
support
the
extension
of
existing
and
granting
of
new
parent
triazolederivative
fungicide
tolerances,
the
Agency
will
be
conducting
a
human­
health
assessment
for
aggregate
exposure
to
1,2,4­
triazole.

The
reregistration
requirements
for
livestock
metabolism
are
fulfilled
based
on
acceptable
goat
and
poultry
metabolism
studies
submitted
to
support
reregistration
of
triadimefon.
HED
has
determined
that
the
residues
of
concern
for
tolerance
expression
and
risk
assessment
in
livestock
are
triadimenol
and
KWG
1342.

The
Pesticide
Analytical
Manual
(
PAM)
Vol.
II
does
not
contain
a
listing
for
triadimenol
(
February
1997
Index).
However,
the
methods
listed
for
triadimefon
can
be
used
for
the
determination
of
triadimenol,
KWG
1323,
KWG
1342,
and
KWG
1732.
PAM
lists
two
gas
chromatography
with
mass
spectrometry
detection
(
GC/
MS)
methods
(
Methods
I
and
II)
for
the
determination
of
triadimenol
and
its
free
and
conjugated
metabolites
in
plant
and
livestock
commodities.
Both
methods
are
common
moiety
methods.
The
reported
limit
of
quantitation
(
LOQ)
is
0.05
and
limit
of
detection
(
LOD)
is
0.01
ppm
for
both
methods.

In
conjunction
with
triadimefon
reregistration,
Bayer
has
proposed
a
GC/
MS
method
(
Report
No.
106549)
for
enforcement
of
tolerances
for
residues
of
triadimefon,
triadimenol,
KWG
1342,
KWG
1323,
and
KWG
1732
in/
on
barley,
corn,
cotton,
oat,
rye,
and
wheat
commodities.
The
method
has
been
successfully
radiovalidated
and
has
undergone
independent
laboratory
validation.
The
reported
method
LOQ
is
0.05
ppm
for
each
analyte
in
cereal
grains
and
0.02
ppm
in
each
analyte
in
cotton.
Additionally,
a
GC
method
using
a
nitrogen
phosphorus
detector
(
NPD;
Report
No.
80488)
is
available
for
determination
of
residues
of
triadimenol,
KWG
1342,
and
KWG
1323
and
is
adequate
for
the
enforcement
of
the
banana
tolerance.
The
method
has
undergone
a
successful
Agency
method
validation
on
tomatoes
and
was
submitted
to
the
FDA
for
publication
in
PAM
Vol.
II.
The
reported
method
LOQ
is
0.01
ppm
for
each
analyte.

The
reregistration
requirements
for
multiresidue
method
testing
for
residues
of
triadimenol,
KWG
1342,
and
KWG
1732
are
satisfied.

The
reregistration
requirements
for
storage
stability
data
are
not
satisfied
for
field
corn,
sweet
corn,
cotton,
and
wheat
forage,
hay,
straw,
and
processed
commodities
pending
the
results
from
the
requested
metabolism
studies.

The
reregistration
requirements
for
data
depicting
the
magnitude
of
triadimenol
residues
of
concern
in
meat,
milk,
poultry,
and
eggs
have
been
fulfilled.
Acceptable
ruminant
and
poultry
feeding
studies
have
been
submitted
and
evaluated.
Triadimenol
is
not
registered
for
use
as
a
direct
livestock
treatment.
The
nature
of
the
residue
in
livestock
is
adequately
defined
for
the
Triadimenol
Summary
Analytical
Chemistry
and
Residue
Data
­
TRED
DP
Barcode:
314891
4
of
44
current
uses.
HED
concludes
that
the
supported
uses
on
barley,
corn,
cotton,
oats,
rye,
and
wheat
result
in
a
40
CFR
§
180.6(
a)(
3)
situation
for
ruminant
commodities;
i.
e.,
there
is
no
reasonable
expectation
of
finite
residues
in
ruminant
commodities.
Therefore,
additional
data
on
the
transfer
of
residues
to
meat,
milk,
poultry,
and
eggs
are
not
required
and
all
tolerances
for
livestock
commodities
should
be
revoked
pending
results
from
the
requested
corn
and
wheat
metabolism
studies.
If
registration
on
additional
commodities
and
livestock
feed
items
are
requested,
then
triazole
and
phenyl­
labeled
livestock
metabolism
studies
would
be
required.
Such
data
may,
in
turn,
trigger
the
need
for
magnitude
of
the
residue
(
feeding)
studies
in
livestock.

The
reregistration
requirements
for
magnitude
of
the
residue
in/
on
bananas
are
fulfilled.
Additional
field
trials
conducted
with
field
corn
(
forage,
grain,
stover),
sweet
corn
(
forage,
K+
CWHR,
grain,
and
stover),
cotton
(
undelinted
seed
and
gin
byproducts),
and
wheat
(
forage,
grain,
hay,
and
straw)
are
required
pending
the
results
from
the
requested
metabolism
studies.

The
reregistration
requirements
for
magnitude
of
the
residue
in
the
processed
commodities
of
field
corn
and
cotton
have
been
fulfilled.
A
wheat
processing
study
conducted
with
triadimenol
applied
to
wheat
as
a
seed
treatment
should
be
submitted
once
the
requested
wheat
metabolism
studies
have
been
submitted
and
reviewed.

No
data
pertaining
to
confined/
field
accumulation
of
triadimenol
residues
in
rotational
crops
have
been
submitted;
however,
confined
rotational
crop
data
for
triadimefon
have
been
submitted
and
translated.
The
reregistration
requirements
for
accumulation
in
rotational
crops
are
fulfilled,
pending
submission
of
the
requested
wheat
and
corn
triazole
labeled
metabolism
studies
for
final
determination
of
the
metabolites
of
concern.
HED
has
concluded
that
limited
field
rotational
crop
studies
for
triadimenol
must
be
submitted.

A
general
summary
of
residue
chemistry
deficiencies
are
listed
below;
details
of
data
requirements
are
listed
in
Table
5.

Regulatory
Recommendations
and
Residue
Chemistry
Deficiencies
°
Separate
metabolism
studies
with
triazole­
14C
and
phenyl­
14C
labeled
triadimenol
applied
as
a
seed
treatment
to
wheat
or
corn
and
cotton
should
be
conducted
to
confirm
the
residues
of
concern.

°
Storage
stability
data
for
triadimenol,
KWG
1342,
and
KWG
1732
in/
on
field
corn,
sweet
corn,
cotton,
and
wheat
processed
commodities
are
required
pending
the
results
from
the
requested
metabolism
studies.
Storage
stability
data
for
KWG
1732
in/
on
wheat
forage,
hay,
and
straw
are
required
pending
the
results
from
the
requested
metabolism
studies.

°
Crop
field
trial
data
depicting
residues
of
triadimenol,
KWG
1342,
and
KWG
1732
in/
on
field
corn
(
forage,
grain,
stover),
sweet
corn
(
forage,
K+
CWHR,
grain,
and
stover),
cotton
(
undelinted
seed
and
gin
byproducts),
and
wheat
(
forage,
grain,
hay,
and
straw)
grown
from
seed
treated
at
the
maximum
rate
are
required
pending
the
results
from
the
requested
metabolism
studies.
Triadimenol
Summary
Analytical
Chemistry
and
Residue
Data
­
TRED
DP
Barcode:
314891
5
of
44
Cl
O
N
N
N
OH
°
A
wheat
processing
study
conducted
with
triadimenol
applied
to
wheat
as
a
seed
treatment
should
be
submitted
once
the
requested
corn
or
wheat
metabolism
studies
have
been
submitted
and
reviewed.

°
Limited
field
rotational
crop
studies
for
triadimenol
must
be
submitted
pending
the
results
from
the
requested
metabolism
studies.

Background
Triadimenol
was
first
registered
after
1984,
and
was
not
subject
to
FIFRA
'
88.
Therefore,
there
have
been
no
previous
comprehensive
reregistration
reviews
of
this
chemical.
This
document
presents
an
overall
and
up­
to­
date
Residue
Chemistry
Science
Assessment
with
respect
to
the
reregistration
of
triadimenol.
The
PC
Code
and
nomenclature
of
triadimenol
are
listed
below
in
Table
1
and
the
physicochemical
properties
are
listed
in
Table
2.
The
structure
of
triadimenol
and
metabolites
of
concern
are
presented
in
Table
3.

Table
1.
Triadimenol
Nomenclature.

Chemical
structure
Common
name
Triadimenol
Molecular
formula
C14H18ClN3O2
Molecular
weight
295.77
g/
mol
IUPAC
name
(
1RS,
2RS;
1RS,
2SR)­
1­(
4­
chlorophenoxy)­
3,3­
dimethyl­
1­(
1H­
1,2,4­
triazol­
1­
yl)
butan­
2­
ol
CAS
name
$­(
4­
chlorophenoxy)­"­(
1,1­
dimethylethyl)­
1H­
1,2,4­
triazole­
1­
ethanol
CAS
number
55219­
65­
3
PC
Code
127201
Current
supported
food/
feed
sites
barley,
cotton,
corn,
oats,
rye,
and
wheat
Table
2.
Physicochemical
Properties
of
Triadimenol
Parameter
Value
Reference
Melting
point/
range
109­
115
°
C
MRID
00125399
Density
at
20
°
C
1.22
g/
mL
MRID
00125399
Water
solubility
at
20
°
C
0.012
g/
100g
of
water
MRID
00125399
Solvent
solubility
at
20
°
C
Triadimenol
is
insoluble
in
aliphatic
hydrocarbons.
1
to
5
g/
100g
of
toluene
10
to
20
g/
100g
of
methylene
chloride
40
to
60
g/
100g
of
cyclohexanone
MRID
00125399
Vapor
pressure
at
20
°
C
less
than
1
mPa
MRID
00125399
Triadimenol
Summary
Analytical
Chemistry
and
Residue
Data
­
TRED
DP
Barcode:
314891
6
of
44
Cl
O
N
N
N
OH
Cl
O
N
N
N
OH
OH
Cl
O
N
N
N
O
Cl
O
N
N
N
O
OH
Cl
O
N
N
N
O
OH
Table
3.
Chemical
Names
and
Structures
of
Triadimenol
and
Its
Metabolites.

Common
name
and
chemical
name
Chemical
structure
Triadimenol
(
KWG
0519)

$­(
4­
chlorophenoxy)­"­(
1,1­
dimethylethyl)­
1H­
1,2,4­
triazole­
1­
ethanol
KWG
1342
1­(
4­
chlorophenoxy)­
3,3­
dimethyl­
3­
hydroxymethyl­
1­(
1H­
1,2,4­
triazol­
1­
yl)­
2­
butanol
Triadimefon
1­(
4­
chlorophenoxy)­
3,3­
dimethyl­
1­(
1H­
1,2,4­
triazol­
1­
yl)­
2­
butanone
KWG
1323
1­(
4­
chlorophenoxy)­
3,3­
dimethyl­
3­
hydroxymethyl­
1­(
1H­
1,2,4­
triazol­
1­
yl)­
2­
butanone
KWG
1732
1­(
4­
chlorophenoxy)­
1­(
1H­
1,2,4­
triazol­
1­
yl)
ethanoic
acid
Triadimenol
Summary
Analytical
Chemistry
and
Residue
Data
­
TRED
DP
Barcode:
314891
7
of
44
Summary
of
Science
Findings
860.1200
Directions
for
Use
Product
List
There
are
five
Bayer
and
one
Wilbur­
Ellis
Company
end­
use
products
containing
the
active
ingredient
triadimenol,
which
are
registered
for
use
on
domestically
grown
food/
feed
crops
as
indicated
in
Table
4.
In
addition,
there
is
one
Section
18
registered
to
the
Texas
Department
of
Agriculture.
There
are
no
SLN
registrations
for
use
of
triadimenol.

Table
4.
Triadimenol
End­
use
Products
(
EPs)
Registered.

EPA
Reg.
No.
Formulation1
Registrant
Product
Name
264­
742
25%
WP
Bayer
CropScience
Baytan
®
Seed
Treatment
Fungicide
264­
760
28.3%
FlC
Bayer
CropScience
Baytan
®
2.6
FS
Seed
Treatment
Fungicide
264­
939
5%
EC
Bayer
CropScience
Gustafson
RTU
®
­
Baytan
®
­
Thiram
Fungicide
264­
941
30%
FlC
Bayer
CropScience
Gustafson
Baytan
®
30
Fungicide
264­
980
13.33
SC
Bayer
CropScience
Protege
Allegiance
Bayton
®
W.
P.
Fungicide
2935­
459
30%
FlC
Wilbur­
Ellis
Company
Wilbur­
Ellis
Baytan
®
Flowable
1.
WP=
Wettable
Powder,
FlC=
Flowable
Concentrate,
EC=
Emulsifiable
Concentrate,
and
SC=
Soluble
Concentrate.

Use
Pattern
Table
A
comprehensive
summary
of
triadimenol
food/
feed
use
patterns
based
on
the
product
labels
registered
to
Bayer,
was
prepared
by
the
Biological
and
Economic
Analysis
Division
(
BEAD;
dated
3/
2/
2005)
and
is
presented
in
Appendix
1.
A
tabular
summary
of
the
residue
chemistry
science
assessments
for
reregistration
of
triadimenol
is
presented
in
Table
5.
The
conclusions
listed
in
Table
5
regarding
the
tolerance
reassessment
eligibility
decision
of
triadimenol
food/
feed
uses
are
based
on
the
use
patterns
being
supported
by
the
basic
producer,
Bayer.
When
end­
use
product
data
call
in's
(
DCIs)
are
developed
(
e.
g.,
at
issuance
of
the
TRED),
the
Registration
Division
(
RD)
should
require
that
all
end­
use
product
labels
(
e.
g.,
MAI
labels,
special
local
needs
(
SLNs),
and
products
subject
to
the
generic
data
exemption)
be
amended
such
that
they
are
consistent
with
the
labels
registered
to
the
basic
producer.

As
indicated
in
the
triadimenol
use
closure
memorandum
(
J.
Pates,
7/
26/
2004),
Bayer
is
no
longer
supporting
the
use
of
triadimenol
on
sorghum
and
has
intentions
on
deleting
the
use
from
all
labels.
Triadimenol
Summary
Analytical
Chemistry
and
Residue
Data
­
TRED
DP
Barcode:
314891
8
of
44
Table
5.
Residue
Chemistry
Science
Assessment
for
the
Tolerance
Reassessment
of
Triadimenol.

GLN
Data
Requirements
Current
Tolerances,
ppm
[
40
CFR]
Must
Additional
Data
Be
Submitted?
References1
860.1200
Directions
for
Use
Not
applicable
(
N/
A)
No
See
Appendix
1
860.1300
Plant
Metabolism
N/
A
Yes10
42123401­
421234032,
427989013,
428534014,5,
92188025­
921880336
860.1300
Livestock
Metabolism
N/
A
No
421234042,
428568015,7,
428649015,8,
43418301­
434183029,
92188034­
921880396
860.1340
Residue
Analytical
Methods
Plant
commodities
N/
A
No
PP#
4F3148,
4387010111,
4404100211,
92188040­
921880436
Livestock
commodities
N/
A
No
434183039,
92188044­
921880486
860.1360
Multiresidue
Methods
N/
A
No
4096980112,
4197660113,
4370540114
860.1380
Storage
Stability
Data
Plant/
processed
commodities
N/
A
Reserved15
4197660216,
4285740117,
4403890111,
4404100111
92188051­
921880536
Livestock
commodities
N/
A
No
4346240118
860.1400
Magnitude
of
the
Residue
­
Water,
Fish,
and
Irrigated
Crops
None
established
No
860.1460
Magnitude
of
the
Residue
­
Food
Handling
None
established
No
860.1480
Meat,
Milk,
Poultry,
and
Eggs
Milk
and
the
Fat,
Meat,
and
Meat
Byproducts
of
Cattle,
Goats,
Hogs,
Horses,
and
Sheep
0.01,
milk;
0.1,
fat,
meat,
and
mbyp
of
cattle,
goats,
hogs,
horses,
and
sheep
[
§
180.450(
b)]
No
92188054­
921880556
Eggs
and
the
Fat,
Meat,
and
Meat
Byproducts
of
Poultry
0.01,
eggs,
fat,
meat,
and
mbyp
[
§
180.450(
b)]
No
92188056­
921880576
860.1500
Crop
Field
Trials
Triadimenol
Summary
Analytical
Chemistry
and
Residue
Data
­
TRED
DP
Barcode:
314891
Table
5.
Residue
Chemistry
Science
Assessment
for
the
Tolerance
Reassessment
of
Triadimenol.

GLN
Data
Requirements
Current
Tolerances,
ppm
[
40
CFR]
Must
Additional
Data
Be
Submitted?
References1
9
of
44
Cereal
Grains
Group
Barley
0.05
[
§
180.450(
a)]
Reserved19
00125407­
0012540920,
4269630821
Corn,
field,
grain
and
aspirated
grain
fractions
0.05,
grain
[
§
180.450(
a)]
Reserved
00125407­
0012540920
Corn,
pop
0.05
[
§
180.450(
a)]
Reserved22
Corn,
sweet
(
K+
CWHR)
0.05
[
§
180.450(
a)]
Reserved
00125407­
0012540920
Oat
0.05
[
§
180.450(
a)]
Reserved19
00125407­
0012540920,
4269630921
Rye
0.05
[
§
180.450(
a)]
Reserved19
00125407­
0012540920,
4271210121
Sorghum,
grain
and
aspirated
grain
fractions
0.01,
grain
[
§
180.450(
a)]
No23
00125407­
0012540920
Wheat,
grain
and
aspirated
grain
fractions
0.05,
grain
[
§
180.450(
a)]
Reserved25
00125407­
0012540920,
4271210121
Fodder,
Forage,
Hay,
and
Straw
of
Cereal
Grains
Group
Barley,
hay
and
straw
0.2,
straw
[
§
180.450(
a)]
Reserved19
00125407­
0012540920,
4269630821
Corn,
field,
forage
and
stover
0.05,
forage
and
fodder
[
§
180.450(
a)]
Reserved
00125407­
0012540920
Corn,
pop,
stover
0.05
[
§
180.450(
a)]
Reserved22
Corn,
sweet,
forage
and
stover
0.05,
forage
and
fodder
[
§
180.450(
a)]
Reserved
00125407­
0012540920
Oat,
forage,
hay,
and
straw
2.5,
green
forage;
0.2,
straw
[
§
180.450(
a)]
Reserved19
00125407­
0012540920,
4269630921
Rye,
forage
and
straw
2.5,
green
forage;
0.1,
straw
[
§
180.450(
a)]
Reserved19
00125407­
0012540920,
4271210121
Sorghum,
forage
and
stover
0.05,
green
forage;
0.01,
fodder
[
§
180.450(
a)]
No23
PP#
3F285424
Triadimenol
Summary
Analytical
Chemistry
and
Residue
Data
­
TRED
DP
Barcode:
314891
Table
5.
Residue
Chemistry
Science
Assessment
for
the
Tolerance
Reassessment
of
Triadimenol.

GLN
Data
Requirements
Current
Tolerances,
ppm
[
40
CFR]
Must
Additional
Data
Be
Submitted?
References1
10
of
44
Wheat,
forage,
hay,
and
straw
2.5,
green
forage;
0.2,
straw
[
§
180.450(
a)]
Reserved25
00125407­
0012540920,
4271210121
Miscellaneous
Commodities
Banana
0.2
[
§
180.450(
a)]
No
4061520126,
4105140127
Cotton,
seed
and
gin
byproducts
0.02,
seed;
0.02,
forage
[
§
180.450(
a)]
Reserved19,28
4124280129
860.1520
Processed
Food/
Feed
Barley
None
established
Reserved30
Corn,
field
None
established
No
4451980131
Cotton
None
established
No
4451980231
Oats
None
established
Reserved30
Rye
None
established
Reserved30
Wheat
None
established
Reserved
4402930132,
4451980331
860.1650
Submittal
of
Analytical
Reference
Standards
N/
A
Yes35
860.1850:
Confined
Rotational
Crops
N/
A
No
4261330133
860.1900:
Field
Rotational
Crops
None
established
Reserved34
1.
Bolded
references
were
submitted
in
support
of
reregistration
of
triadimefon.
Unbolded
references
were
submitted
in
support
of
registration
of
triadimenol.

2.
DP
Barcode
D174151,
9/
23/
92,
C.
Swartz.

3.
DP
Barcode
D194719,
10/
20/
93,
C.
Swartz.

4.
DP
Barcode
D194676,
11/
3/
93,
S.
Knizner.

5.
EPA
Memorandum,
no
DP
Barcode,
12/
9/
93,
S.
Knizner.

6.
Triadimefon
Phase
4
Review,
1/
31/
91,
S.
Funk.

7.
DP
Barcode
D194819,
11/
2/
93,
S.
Knizner.

8.
DP
Barcode
D194786,
11/
2/
93,
S.
Knizner.

9.
DP
Barcode
D208890,
12/
16/
94,
S.
Knizner.
Triadimenol
Summary
Analytical
Chemistry
and
Residue
Data
­
TRED
DP
Barcode:
314891
11
of
44
10.
Separate
metabolism
studies
with
triazole­
14C
and
phenyl­
14C
labeled
triadimenol
applied
as
a
seed
treatment
to
corn
or
wheat
and
cotton
should
be
conducted
to
confirm
the
residues
of
concern.

11.
DP
Barcodes
D222403,
D227497,
and
D227543,
7/
13/
00,
J.
Punzi.

12.
CB
Nos.
4887,
4888,
4889,
and
4890,
2/
23/
89,
E.
Haeberer.

13.
Forwarded
to
FDA
for
inclusion
in
PAM
Vol.
I
(
L.
Edwards
memo
of
6/
30/
92).

14.
Forwarded
to
FDA
for
inclusion
in
PAM
Vol.
I.

15.
Storage
stability
data
for
KWG
1732
are
only
available
for
wheat
grain.
Storage
stability
data
for
triadimenol,
KWG
1342,
and
KWG
1732
in/
on
field
corn
forage,
grain,
and
stover;
sweet
corn
forage,
kernel
plus
cob
with
husks
removed
(
K+
CWHR),
grain,
and
stover;
cotton
undelinted
seed
and
gin
byproducts
are
required
pending
the
results
from
the
requested
metabolism
studies.
Storage
stability
data
for
KWG
1732
in/
on
wheat
forage,
hay,
and
straw
are
required
pending
the
results
from
the
requested
metabolism
studies.
Samples
from
the
required
crop
field
trials
should
be
stored
using
the
conditions
and
intervals
under
which
residues
are
known
to
be
stable.
Additional
storage
stability
data
will
be
required
if
samples
are
not
stored
under
these
conditions
and
intervals.

16.
DP
Barcodes
D168542
and
D178884,
12/
22/
92,
S.
Hummel.

17.
DP
Barcode
D194783,
11/
17/
93,
S.
Knizner.

18.
DP
Barcode
D210160,
2/
23/
95,
S.
Knizner.

19.
Crop
field
trial
data
depicting
residues
of
triadimenol,
KWG
1342,
and
KWG
1732
in/
on
field
corn
(
forage,
grain,
stover),
sweet
corn
(
forage,
K+
CWHR,
grain,
and
stover),
cotton
(
undelinted
seed
and
gin
byproducts),
and
wheat
(
forage,
grain,
hay,
and
straw)
grown
from
seed
treated
at
the
maximum
rate
are
required
pending
the
results
from
the
requested
metabolism
studies.
No
data
depicting
residues
of
KWG
1732
in/
on
barley,
oat,
and
rye
commodities
are
available.
The
requested
crop
field
trial
data
for
wheat
may
be
translated
to
barley,
oat,
and
rye
commodities
provided
that
a
confirmatory
study
with
one
of
these
grains
is
conducted
in
a
suitable
growing
region.

20.
PP#
3F2854,
8/
1/
83,
A.
Smith.

21.
DP
Barcode
D189881,
11/
3/
93,
D.
Davis.

22.
Data
to
support
use
on
popcorn
can
be
translated
from
field
corn.

23.
No
data
are
available
depicting
triadimenol
residues
of
concern
in/
on
sorghum
commodities
grown
from
seed
treated
with
triadimenol,
however,
the
basic
producer
is
no
longer
supporting
the
use
on
sorghum
and
will
remove
the
use
from
all
labels.

24.
The
tolerance
for
sorghum
commodities
was
established
under
PP#
3F2854
25.
No
data
are
available
depicting
the
magnitude
of
residues
of
KWG
1732
in/
on
wheat
commodities
following
treatment
of
the
seed
with
triadimenol.
Crop
field
trial
data
depicting
residues
of
triadimenol,
KWG
1342,
and
KWG
1732
in/
on
wheat
grain,
forage,
hay,
and
straw
grown
from
seed
treated
at
the
maximum
rate
must
be
submitted.
Data
for
wheat
aspirated
grain
fractions
are
not
required
because
triadimenol
is
applied
as
a
seed
treatment.

26.
CB
No.
3926,
1/
6/
89,
S.
Malak.

27.
CB
No.
5221,
5/
16/
89,
S.
Malak.

28.
As
a
result
of
changes
in
Table
1
of
OPPTS
860.1000,
crop
field
trial
data
for
cotton
gin
byproducts
must
now
be
submitted.
Triadimenol
Summary
Analytical
Chemistry
and
Residue
Data
­
TRED
DP
Barcode:
314891
12
of
44
29.
DEB
No.
5865,
3/
12/
90,
L.
Rodriquez.

30.
A
wheat
processing
study
conducted
with
triadimenol
applied
to
wheat
as
a
seed
treatment
should
be
submitted
once
the
requested
wheat
metabolism
studies
have
been
submitted
and
reviewed.
Data
to
satisfy
barley,
oats,
and
rye
may
be
translated
from
wheat.

31.
DP
Barcode
D322304,
10/
14/
2005,
S.
Ary.

32.
The
registrant
proposed
translating
data
from
a
triadimefon
wheat
grain
processing
study;
however,
these
data
cannot
be
translated
to
triadimenol
due
to
differences
in
the
use
patterns
(
seed
treatment
vs.
late
season
foliar
sprays)
that
are
likely
to
impact
the
potential
concentration
of
residues.

33.
DP
Barcode
D186937,
11/
3/
93,
S.
Knizner.

34.
Limited
field
rotational
crop
studies
for
triadimenol
must
be
submitted.

35.
Analytical
reference
standards
must
be
replenished
as
requested
by
the
Repository.

860.1300
Nature
of
the
Residue
­
Plants
The
reregistration
requirements
for
plant
metabolism
have
not
been
fulfilled.
Two
metabolism
studies
with
triadimenol
have
been
submitted
and
are
currently
under
review
by
the
Agency
and
are
summarized
below.

In
the
wheat
study
(
Bayer
Report
No.
69209,
10/
15/
1980),
wheat
seeds
were
treated
with
[
phenyl­
14C]
triadimenol
at
the
currently
registered
rate
of
0.5
oz
ai/
100
lbs
of
seed.
In
mature
wheat
straw,
triadimenol
accounted
for
58%
of
the
total
radioactive
residue
(
TRR),
KWG
1342
accounted
for
36%
of
the
TRR,
while
triadimefon
accounted
for
6%
of
the
TRR.
Extraction
of
mature
grain
did
not
produce
enough
activity
to
unequivocally
identify
any
metabolites
in
the
grain.
It
is
noted
that
52%
of
the
activity
originally
applied
was
recovered,
the
remaining
was
assumed
to
be
lost
as
14CO
2
due
to
microbiological
degradation.

In
the
sugar
beet
study,
(
Bayer
Study
No.
M1731125­
0,
1/
23/
2003),
sugar
beets
were
treated
with
two
foliar
applications
of
[
phenyl­
14C]
triadimenol
at
137
g
ai/
ha
per
application
using
an
EC
250
formulation.
In
mature
roots,
triadimenol
accounted
for
64%
of
the
TRR,
KWG
1342
accounted
for
17.7%
of
the
TRR,
and
a
glucoside
of
triadimenol
(
HYA604)
accounted
for
5.3%
TRR.
In
mature
leaves,
triadimenol
was
found
at
73.1%
TRR,
two
glucosides
of
triadimenol
were
found
at
a
total
of
15.9%
TRR,
and
KWG
1342
at
2.6%
TRR.
In
forage
leaves,
triadimenol
accounted
for
26%
of
TRR
while
its
two
glucosides
accounted
for
a
total
of
56.3%
TRR,
and
KWG
1342
was
found
at
2.8%
TRR.

Additionally,
metabolism
studies
conducted
with
triadimefon
have
been
received
and
are
summarized
below.
These
studies
were
conducted
with
grapes,
cucumbers,
tomatoes,
and
wheat.

Cucumber
and
Tomato
(
MRID
42123401)

In
the
cucumber
and
tomato
metabolism
studies,
seedlings
were
treated
with
[
phenyl­
14C]
triadimefon
at
approximately
1x
the
maximum
rate
for
cucumbers.
Selected
plants
were
treated
two
additional
times,
beginning
at
fruit
set.
Metabolism
of
triadimefon
in
tomato
and
cucumber
seedlings
receiving
a
single
foliar
application
appears
to
consist
of
rapid
degradation
of
Triadimenol
Summary
Analytical
Chemistry
and
Residue
Data
­
TRED
DP
Barcode:
314891
13
of
44
the
parent,
concomitant
with
an
increase
in
triadimenol.
Hydrolysis
of
water­
soluble
radiocarbon
and
foliage
samples
from
cucumber
seedlings
released
triadimefon
and
triadimenol,
as
well
as
low
levels
of
KWG
1323
and
KWG
1342.
These
additional
metabolites
were
not
detected
in
the
tomato
seedlings.
Degradation
of
triadimefon
in
mature
cucumber
and
tomato
plants
appeared
to
be
similar
to
that
in
the
seedlings,
with
minor
differences.
The
fruit
and
foliage
differed
in
their
ability
to
metabolize
the
parent.
In
both
tomato
and
cucumber
fruit,
the
terminal
degradation
product
was
primarily
triadimenol,
while
the
foliage
of
both
tomato
and
cucumber
exhibited
a
more
complex
series
of
degradation
products.
In
tomato,
triadimefon
and
triadimenol
account
for
96.6%
TRR
one
day
after
treatment,
88.1%
TRR
7
days
after
treatment,
83.8%
TRR
14
days
after
treatment,
80.0%
TRR
21
days
after
treatment,
and
75.7%
TRR
28
days
after
treatment.
Similar
results
were
reported
for
cucumber.
KWG
1732
was
not
identified
in
either
tomatoes
or
cucumbers.

Grape
(
MRID
42123403)

In
a
grape
metabolism
study,
mature
fruit
were
harvested
56
days
following
treatment
of
an
established
vine
with
[
phenyl­
14C]
triadimefon;
immature
fruit
were
harvested
at
various
earlier
intervals.
A
rapid
decline
in
total
radioactivity
was
observed,
due
to
the
volatility
of
triadimefon.
The
decline
in
the
quantity
of
parent
observed
was
accompanied
by
a
buildup
of
the
metabolite
triadimenol.
Triadimenol
accounted
for
55.6%
of
TRR
in
mature
grapes
while
triadimefon
was
only
detected
at
1.1%
TRR.
The
remainder
of
the
identified
radioactivity
was
comprised
of
KWG
1342
and
its
conjugates
(
15.5%
TRR),
triadimenol
conjugates
(
5.6%
TRR),
and
p­
chlorophenol
and
its
conjugates
(
6.2%
TRR).
KWG
1732
was
not
identified
in
the
study.

Wheat
(
MRID
42853401)

Following
foliar
treatment
of
wheat
with
[
phenyl­
14C]
triadimefon
at
a
rate
of
236
g
ai/
A,
approximately
2x
the
maximum
registered
rate
for
wheat,
the
metabolite
KWG
1732
was
the
major
residue
identified
(
35%
TRR)
in
wheat
grain;
a
glucoside
of
KWG
1342
was
the
other
major
residue
identified
(
21%
TRR)
in
wheat
grain.
Additionally,
triadimefon
accounted
for
1%
TRR,
triadimenol
accounted
for
6%
TRR
and
its
glucoside
was
found
at
6%
TRR;
pchlorophenol
was
also
identified
at
5%
TRR.
In
wheat
forage,
triadimefon
was
found
at
31­
74%
TRR
and
triadimenol
was
found
at
12­
35%
TRR;
together
they
accounted
for
the
majority
of
residues
(
66­
86%
TRR);
p­
chlorophenol
and
its
glucoside
were
also
identified,
at
9­
16%
TRR.
In
wheat
straw,
triadimenol
and
its
conjugates
accounted
for
the
majority
of
the
radioactivity
at
53%
TRR
and
triadimefon
accounted
for
only
1%
TRR;
p­
chlorophenol
and
its
conjugates
and
KWG
1342
and
its
conjugates
were
also
identified,
at
21%
and
19%
TRR,
respectively.

The
Health
Effects
Division
(
HED)
has
examined
the
results
of
these
studies
and
determined
that
the
triadimefon
residues
of
concern
in/
on
apples,
grapes,
pears,
pineapples,
and
raspberries
for
tolerance
expression
are
triadimefon
and
triadimenol
and
for
risk
assessment
are
triadimefon,
triadimenol,
KWG
1323,
and
KWG
1342
(
S.
Ary,
D314742,
11/
23/
2005).
Of
these
compounds,
triadimenol
and
KWG
1342
are
the
compounds
that
are
currently
regulated
for
plant
commodities.
The
chemical
names
and
structures
of
these
compounds
are
presented
in
Table
3.

HED
has
determined
that
translation
of
metabolism
data
from
triadimefon
to
triadimenol
is
not
appropriate
for
the
existing
uses
on
cereal
grains.
The
metabolism
studies
with
triadimefon
were
Triadimenol
Summary
Analytical
Chemistry
and
Residue
Data
­
TRED
DP
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14
of
44
conducted
using
a
foliar
application
and
triadimenol
is
used
only
as
a
seed
treatment.
In
the
submitted
triadimenol
wheat
study,
residues
in
grain
were
not
identifiable
due
to
the
low
activity
found
in
wheat
grain.
Therefore,
HED
concludes
that
the
nature
of
the
residue
in
cereal
grains
is
not
adequately
understood;
however,
based
on
chemical
structure
and
the
probable
metabolic
pathway
of
triadimenol,
the
residues
of
concern
for
tolerance
expression
and
risk
assessment
are
likely
to
be
triadimenol,
KWG
1342,
and
KWG
1732
in/
on
cereal
grains
(
barley,
corn,
oats,
rye,
and
wheat)
and
cotton.
The
wheat
metabolism
study
conducted
with
triadimefon
indicate
that
KWG
1732
is
the
major
metabolite
found
in
grain
at
35%
TRR
and
KWG
1342
at
21%
TRR
in
grain.
Triadimenol
accounted
for
12%
TRR.
It
is
also
noted
that
the
submitted
wheat
processing
study
conducted
with
triadimenol
applied
as
a
seed
treatment
identified
quantifiable
residues
of
KWG
1732.
There
have
been
no
previous
triazole
labeled
studies
conducted
with
triadimenol
applied
as
a
seed
treatment
to
commodities
and
data
from
the
available
soil
metabolism
studies
conducted
with
triadimefon
indicate
that
soil
microbes
metabolize
the
triazole
fungicide
to
free
triazole,
which
may
be
taken
up
into
the
plant.
Separate
metabolism
studies
with
triazole­
14C
and
phenyl­
14C
labeled
triadimenol
applied
as
a
seed
treatment
to
corn
or
wheat
and
cotton
should
be
conducted
to
confirm
the
residues
of
concern.

The
residues
of
concern
for
tolerance
expression
and
risk
assessment
for
bananas
are
triadimenol
and
KWG
1342,
which
are
based
on
the
available
metabolism
data
conducted
with
triadimefon
applied
to
an
established
grape
vine
and
the
field
trial
data
conducted
with
triadimenol
applied
to
the
soil
of
banana
groves.
The
metabolism
study
conducted
with
triadimefon
applied
to
grapes
indicate
that
triadimenol
is
the
major
metabolite
identified
at
56%
along
with
KWG
1342
at
16%.
The
available
field
trial
data
indicate
that
residues
of
triadimenol
and
KWG
1342
are
both
likely
to
be
found
in/
on
bananas
as
indicated
in
Table
9.

860.1300
Nature
of
the
Residue
­
Livestock
The
reregistration
requirements
for
livestock
metabolism
are
fulfilled
based
on
acceptable
goat
and
poultry
metabolism
studies
submitted
to
support
reregistration
of
triadimefon.

For
the
ruminant
study,
a
lactating
goat
received
[
phenyl­
14C]
triadimefon
at
86.4
ppm
for
three
consecutive
days
in
feed.
Triadimefon
was
detected
at
low
levels
in
milk
and
fat
(<
5%
TRR)
but
was
not
detected
in
kidney,
liver,
or
muscle.
The
major
residue
identified
was
KWG
1342
glucuronide
(
6­
47%
TRR).
Triadimenol
and
its
conjugates
comprised
a
major
portion
of
the
residue
in
tissues
and
milk
(
totals
of
9­
42%
TRR).
The
remainder
of
the
radioactivity
was
identified
as
KWG
1323
glucuronide
(
19­
22%
TRR)
and
KWG
1342
(
1­
6%
TRR)
and
its
sulfate
(
1­
15%
TRR
in
tissues,
43%
TRR
in
milk).

For
the
poultry
study,
16
laying
hens
received
[
phenyl­
14C]
triadimefon
at
28.7
ppm
for
three
consecutive
days
in
feed.
Triadimefon
was
identified
in
fat
and
eggs
(
4­
17%
TRR)
but
was
not
detected
in
liver
or
muscle.
Triadimenol
and
its
related
compounds
were
the
major
metabolites
identified
(
totals
of
41­
49%
TRR).
The
remainder
of
the
radioactivity
was
identified
as
KWG
1342
and
its
related
compounds
(
totals
of
10­
36%
TRR),
p­
chlorophenol
(
liver
and
fat
only
at
2­
4%
TRR),
chlorophenoxytriazolyl
acetic
acid
(
muscle
only
at
3%
TRR),
and
KWG
1323
(
eggs
and
fat
only
at
3­
5%
TRR).

HED
has
determined
that
the
residues
of
concern
for
tolerance
expression
and
risk
assessment
in
Triadimenol
Summary
Analytical
Chemistry
and
Residue
Data
­
TRED
DP
Barcode:
314891
15
of
44
livestock
are
triadimenol
and
KWG
1342.
The
chemical
names
and
structures
of
these
compounds
are
presented
in
Table
3.

860.1340
Residue
Analytical
Methods
­
Plants
The
Pesticide
Analytical
Manual
(
PAM)
Vol.
II
does
not
contain
a
listing
for
triadimenol
(
February
1997
Index).
However,
the
methods
listed
for
triadimefon
can
be
used
for
determination
of
triadimenol,
KWG
1342,
and
KWG
1732.
PAM
lists
two
GC/
MS
methods
(
Methods
I
and
II)
for
the
determination
of
triadimenol
and
its
free
and
conjugated
metabolites
in
all
crops.
Both
methods
are
common
moiety
methods.
In
Method
I,
residues
are
extracted
using
methanol
or
methanol:
acetone
(
2:
1,
v:
v).
Following
cleanup
on
an
ion­
exchange
column,
the
total
residues
are
hydrolyzed
to
p­
chlorophenol
using
concentrated
HCl.
p­
Chlorophenol
is
isolated
by
steam
distillation
followed
by
acid/
base
partitioning
and
then
derivatized
with
dinitrofluorobenzene
for
determination
by
GC/
MS
using
selected
ion
monitoring.
Residues
are
expressed
in
triadimenol
equivalents.
Method
II
is
similar
to
Method
I.
The
reported
limit
of
quantitation
(
LOQ)
is
0.05
ppm
and
limit
of
detection
(
LOD)
is
0.01
ppm
for
both
methods.

In
conjunction
with
triadimefon
reregistration,
Bayer
has
proposed
a
GC/
MS
method
(
Report
No.
106549)
for
enforcement
of
tolerances
for
residues
of
triadimefon,
triadimenol,
KWG
1342,
KWG
1323,
and
KWG
1732
in/
on
barley,
corn,
cotton,
oat,
rye,
and
wheat
commodities.
Briefly,
residues
are
extracted
under
reflux
in
methanol:
water,
hydrolyzed
with
cellulase
at
37
°
C
overnight,
and
partitioned
with
dichloromethane:
acetonitrile.
The
aqueous
phase,
containing
KWG
1732,
is
partitioned
with
acidic
ethyl
acetate,
and
methylated
with
trimethylsilyl
diazomethane
for
analysis
by
GC/
MS.
The
dichloromethane
phase
is
cleaned
up
by
gel
permeation
chromatography
and
separated
by
semi­
preparative
HPLC
into
two
fractions:
one
containing
triadimefon
and
triadimenol
and
the
other
containing
KWG
1323
and
KWG
1342.
Triadimefon
and
triadimenol
are
determined
directly
by
GC/
MS;
KWG
1323
and
KWG
1342
are
derivatized
prior
to
GC/
MS
analysis.
The
method
has
been
successfully
radiovalidated
and
has
undergone
independent
laboratory
validation.
The
reported
method
LOQ
is
0.05
ppm
for
each
analyte
in
cereal
grains
and
0.02
ppm
in
each
analyte
in
cotton.

A
GC/
NPD
method
(
Report
No.
80488)
is
available
for
determination
of
residues
of
triadimenol,
KWG
1342,
and
KWG
1323
and
is
adequate
for
data­
collection
and
tolerance
enforcement
in
bananas.
Briefly,
residues
are
extracted
under
reflux
in
methanol:
water
(
7:
3,
v:
v)
and
the
extract
is
buffered
and
hydrolyzed
in
cellulase
at
37
°
C
overnight
to
release
conjugated
residues.
Residues
are
partitioned
into
dichloromethane,
cleaned
up
by
gel
permeation
chromatography,
and
separated
into
parent
(
triadimenol)
and
metabolite
(
KWG
1342)
fractions
by
semi­
preparative
HPLC.
The
metabolite
fraction
residues
are
derivatized
with
trifluoroacetic
anhydride
and
all
residues
are
determined
using
GC/
NPD.
The
method
has
undergone
a
successful
Agency
method
validation
on
tomatoes
(
PP#
4F3148;
4/
3/
86)
and
was
submitted
to
the
FDA
for
publication
in
PAM
Vol.
II
(
letter
to
A.
Marcotte
from
M.
Firestone,
4/
9/
1986),
however,
the
February
1997
update
to
the
PAM
Vol.
II
index
does
not
include
an
entry
for
triadimenol.
The
reported
method
LOQ
is
0.01
ppm
for
each
analyte.

860.1340
Residue
Analytical
Methods
­
Livestock
The
Pesticide
Analytical
Manual
(
PAM)
Vol.
II
does
not
contain
a
listing
for
triadimenol
Triadimenol
Summary
Analytical
Chemistry
and
Residue
Data
­
TRED
DP
Barcode:
314891
16
of
44
(
February
1997
Index).
However,
the
methods
listed
for
triadimefon
can
be
used
for
determination
of
triadimenol
and
KWG
1342
in
livestock
commodities.
PAM
lists
two
GC/
MS
methods
(
Methods
I
and
II)
for
the
determination
of
triadimenol
and
its
free
and
conjugated
metabolites
in
livestock
commodities;
these
are
the
same
methods
as
described
above
for
plant
commodities.
The
reported
LOQ
is
0.05
and
LOD
is
0.01
ppm
for
both
methods.

860.1360
Multiresidue
Methods
The
reregistration
requirements
for
multiresidue
method
testing
for
residues
of
triadimenol
and
its
metabolites
are
satisfied.
The
10/
99
FDA
PESTDATA
database
(
PAM
Volume
I,
Appendix
I)
indicates
that
triadimenol
is
completely
recovered
(>
80%)
using
Multiresidue
Methods
Section
302
(
Luke
Method;
Protocol
D);
triadimenol
is
not
recovered
using
Multiresidue
Methods
Sections
303
(
Mills,
Onley,
and
Gaither;
Protocol
E,
nonfatty)
and
304
(
Mills,
fatty
food).
Metabolite
KWG
1732
is
not
recovered
using
Sections
303
and
304.
Although
multiresidue
method
testing
data
have
been
submitted
for
KWG
1342,
the
PESTDATA
database
does
not
contain
any
recovery
data
for
this
metabolite.

860.1380
Storage
Stability
Data
­
Plants
The
reregistration
requirements
for
storage
stability
data
are
not
satisfied
for
field
corn
forage,
grain,
and
stover;
sweet
corn
forage,
kernel
plus
cob
with
husks
removed
(
K+
CWHR),
grain,
and
stover;
cotton
undelinted
seed
and
gin
byproducts;
and
wheat
forage,
hay,
and
straw,
and
wheat
processed
commodities
pending
the
results
from
the
requested
metabolism
studies.
Storage
stability
data
for
triadimenol,
KWG
1342,
and
KWG
1732
in/
on
field
corn
forage,
grain,
and
stover;
sweet
corn
forage,
kernel
plus
cob
with
husks
removed
(
K+
CWHR),
grain,
and
stover;
cotton
undelinted
seed
and
gin
byproducts;
and
wheat
processed
commodities
are
required
pending
the
results
from
the
requested
metabolism
studies.
Storage
stability
data
for
KWG
1732
in/
on
wheat
forage,
hay,
and
straw
are
required
pending
the
results
from
the
requested
metabolism
studies.

The
available
storage
stability
data
indicate
that
residues
of
triadimenol
and
its
metabolite
KWG
1342
are
stable
for
up
to
24
months
of
frozen
storage
(#­
20
°
C)
in/
on
the
following
commodities:
apple;
cucumber;
grapes,
grape
juice,
and
raisins;
pineapple;
sugar
beet
roots,
tops,
and
molasses;
tomatoes;
and
wheat
grain
and
forage.
These
analytes
are
also
stable
in
grape
pomace
(
wet
and
dry)
for
up
to
6
months.
Residues
of
triadimenol
are
stable
in
coffee
beans
for
up
to
6
months
of
frozen
storage.
When
corrected
for
concurrent
method
recoveries,
residues
of
triadimenol
appear
to
decline
after
24
months
in
the
following
crop
matrices:
asparagus
(
18%),
wheat
straw
(
30%),
bran
(
29%),
flour
(
25%),
and
grain
dust
(
17%).
Residues
of
KWG
1342
also
appeared
to
decline
in
asparagus
(
15%)
and
wheat
bran
(
20%)
after
24
months
of
frozen
storage,
and
in
coffee
beans
(
79%)
after
40
days
of
storage.
Additionally,
storage
stability
data
indicate
that
KWG
1732
is
stable
in
wheat
grain
stored
frozen
at
#­
20
°
C
for
up
to
2.5
years.

860.1380
Storage
Stability
Data
­
Livestock
Adequate
storage
stability
data
for
residues
of
triadimenol
and
KWG
1342
in
livestock
commodities
have
been
submitted
and
evaluated
in
conjunction
with
triadimefon
reregistration.
The
available
storage
stability
data,
collected
using
samples
from
the
triadimefon
livestock
Triadimenol
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Analytical
Chemistry
and
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Data
­
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DP
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17
of
44
metabolism
studies,
indicate
that
residues
of
triadimefon
and
its
regulated
metabolites
(
including
triadimenol,
KWG
1323,
and
KWG
1342)
are
stable
in
goat
milk,
fat,
and
liver
during
approximately
14,
26,
and
29
months,
respectively,
of
frozen
storage.
Residues
were
found
to
be
stable
in
poultry
muscle
and
eggs
during
approximately
15
months
of
frozen
storage.
These
data
are
adequate
to
validate
the
storage
intervals
of
livestock
commodity
samples
collected
from
the
feeding
studies.

860.1400
Water,
Fish,
and
Irrigated
Crops
Triadimenol
is
presently
not
registered
for
direct
use
on
water
or
aquatic
food
and
feed
crops;
therefore,
no
residue
chemistry
data
are
required
under
these
guideline
topics.

860.1460
Food
Handling
Triadimenol
is
presently
not
registered
for
use
in
food­
handling
establishments;
therefore,
no
residue
chemistry
data
are
required
under
this
guideline
topic.

860.1480
Meat,
Milk,
Poultry,
and
Eggs
The
reregistration
requirements
for
data
depicting
the
magnitude
of
triadimefon
residues
of
concern
in
meat,
milk,
poultry,
and
eggs
have
been
fulfilled.
Acceptable
ruminant
and
poultry
feeding
studies
have
been
submitted
and
evaluated
(
PP#
2F2665).
In
these
studies,
livestock
were
fed
a
1:
1
mixture
of
triadimefon
and
triadimenol.
Samples
were
analyzed
for
bound
and
free
residues
of
triadimefon,
triadimenol,
KWG
1342,
and
KWG
1323
using
the
GC/
MS
methods
listed
in
PAM
Vol.
II.
The
reported
LOQ
is
0.05
ppm
and
LOD
is
0.01
ppm
for
both
methods.
The
theoretical
dietary
burden
(
TDB)
to
livestock
is
presented
below
in
Table
6.

Table
6.
Calculation
of
Dietary
Burdens
of
Triadimenol
to
Livestock.

Feed
Commodity
%
Dry
Matter1
%
Diet1
Tolerance
(
ppm)
2
Dietary
Contribution
(
ppm)
3
Beef
Cattle
Corn,
field,
forage
40
20
0.05
0.025
Corn,
field,
grain
88
40
0.05
0.023
Corn,
field,
stover
83
25
0.05
0.015
Cotton,
undelinted
seed,
meal
89
15
0.02
0.003
TOTAL
BURDEN
N/
A4
100
N/
A
0.066
Dairy
Cattle
Corn,
field,
forage
40
35
0.05
0.044
Corn,
field,
grain
88
35
0.05
0.020
Corn,
field,
stover
83
15
0.05
0.009
Cotton,
undelinted
seed,
meal
89
15
0.02
0.003
TOTAL
BURDEN
N/
A
100
N/
A
0.076
Poultry
and
Swine
Corn,
field,
grain
N/
A
85
0.05
0.043
Cotton,
undelinted
seed,
meal
N/
A
15
0.02
0.003
Triadimenol
Summary
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Chemistry
and
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Data
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DP
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Table
6.
Calculation
of
Dietary
Burdens
of
Triadimenol
to
Livestock.

18
of
44
TOTAL
BURDEN
N/
A
100
N/
A
0.046
1.
OPPTS
Guideline
860.1200,
Table
1
(
August
1996).
2.
Reassessed
tolerances
from
Table
14.
3.
Contribution
=
(%
diet
/
%
dry
matter)
x
(
reassessed
tolerance).
4.
N/
A
=
Not
applicable.

Ruminant.
In
the
ruminant
feeding
study,
cattle
were
fed
triadimenol:
triadimefon
(
1:
1)
at
total
dose
levels
of
25,
75,
and
250
ppm.
The
resulting
triadimenol
dose
levels
of
12.5,
37.5,
and
125
ppm
represent
189x,
568x,
and
1890x
the
theoretical
dietary
burden
to
beef
cattle,
and
164x,
493x,
and
1650x
the
TDB
to
dairy
cattle.
The
results
of
the
study
are
summarized
in
Table
7.

Table
7.
Estimation
of
Potential
Triadimefon,
Triadimenol,
KWG
1342,
and
KWG
1323
Residues
in
Milk
and
Tissues
of
Beef
and
Dairy
Cows
Using
Data
from
the
Ruminant
Feeding
Study.

Matrix
25
ppm
feeding
level
(
12.5
ppm
triadimenol)
1
Estimated
residues
at
1x
TDB
using
25
ppm
feeding
level2
75
ppm
feeding
level
(
37.5
ppm
triadimenol)
1
Estimated
residues
at
1x
TDB
using
75
ppm
feeding
level2
250
ppm
feeding
level
(
125
ppm
triadimenol)
1
Estimated
residues
at
1x
TDB
using
250
ppm
feeding
level2
Milk
0.014
(
0.007)
0.000043
0.035
(
0.018)
0.000036
0.076
(
0.038)
0.000023
Muscle
<
0.01
0.000026
0.019
(
0.009)
0.000016
0.043
(
0.022)
0.000012
Kidney
0.412
(
0.206)
0.0011
0.787
(
0.394)
0.00069
2.27
(
1.14)
0.00060
Liver
0.093
(
0.047)
0.00025
0.287
(
0.144)
0.00025
1.00
(
0.50)
0.00026
Fat
0.024
(
0.012)
0.000063
0.086
(
0.043)
0.000076
0.211
(
0.106)
0.000056
1.
Numbers
in
parentheses
refer
to
triadimenol
residue
levels
and
were
used
to
calculate
the
estimated
residues
at
1x
TDB.
It
is
assumed
that
one­
half
of
the
total
residues
found
is
due
to
triadimenol.
2.
Estimated
triadimenol
residues
=
(
total
dietary
contribution,
Table
6
/
feeding
level)
x
(
residue
from
feeding
studies;
residues
reported
at
less
than
the
LOD
of
0.01,
half
the
LOD
was
used).
Whole
milk
was
calculated
using
TDB
from
dairy
cattle.
Muscle,
fat,
liver,
and
kidney
were
calculated
using
TDB
from
beef
cattle.

The
maximum
residue
of
triadimenol
observed
in
any
matrix
in
the
ruminant
feeding
study
was
kidney
at
0.206
ppm
after
dosing
at
an
exaggerated
feeding
level
of
12.5
ppm
or
189x
the
beef
cattle
dietary
burden.
Based
on
the
189x
dosing
level
for
beef
cattle,
the
maximum
expected
residues
of
triadimenol
in
kidney
at
a
10x
level
are
0.011
ppm,
which
is
less
than
the
livestock
method
LOQ
of
0.05
ppm.

Swine.
A
swine
feeding
study
is
not
available;
therefore,
maximum
potential
residues
resulting
from
dietary
exposure
were
estimated
using
data
from
the
above
ruminant
feeding
study.
The
maximum
residue
of
triadimenol
observed
in
any
matrix
in
the
ruminant
feeding
study
was
kidney
at
0.206
ppm
after
dosing
at
an
exaggerated
feeding
level
of
12.5
ppm
or
272x
the
swine
theoretical
dietary
burden.
Based
on
the
272x
dosing
level
for
swine,
the
maximum
expected
residues
of
triadimenol
in
kidney
at
a
10x
level
are
0.0076
ppm,
which
is
less
than
the
livestock
method
LOQ
of
0.05
ppm.

Poultry.
In
the
poultry
feeding
study,
laying
hens
were
fed
triadimenol:
triadimefon
(
1:
1)
at
dose
levels
of
10,
25,
75,
and
250
ppm
for
29
days.
The
resulting
triadimenol
dose
levels
of
5,
12.5,
37.5,
and
125
ppm
represent
109x,
272x,
815x,
and
2720x
the
theoretical
dietary
burden
to
poultry.
Egg
samples
were
collected
daily
on
days
24
through
28
of
the
study.
All
tissue
samples
Triadimenol
Summary
Analytical
Chemistry
and
Residue
Data
­
TRED
DP
Barcode:
314891
19
of
44
from
the
highest
dosing
level
were
analyzed;
only
liver,
which
was
found
to
contain
the
maximum
residues,
was
analyzed
at
lower
dosing
levels.
The
results
of
the
study
are
summarized
in
Table
8.

Table
8.
Estimation
of
Potential
Triadimefon,
Triadimenol,
KWG
1342,
and
KWG
1323
Residues
in
Eggs
and
Tissues
of
Laying
Hens
Using
Data
from
the
Poultry
Feeding
Study.

Matrix
10
ppm
feeding
level
(
5
ppm)
Estimated
residues
at
1x
TDB
using
10
ppm
feeding
level1
25
ppm
feeding
level
(
12.5
ppm)
Estimated
residues
at
1x
TDB
using
25
ppm
feeding
level1
75
ppm
feeding
level
(
37.5
ppm)
Estimated
residues
at
1x
TDB
using
75
ppm
feeding
level1
250
ppm
feeding
level
(
125
ppm)
Estimated
residues
at
1x
TDB
using
250
ppm
feeding
level1
Muscle
ND3
N/
A3
ND
N/
A
ND
N/
A
0.023
(
0.016)
0.0000058
Fat
ND
N/
A
ND
N/
A
ND
N/
A
0.148
(
0.074)
0.000027
Skin
ND
N/
A
ND
N/
A
ND
N/
A
0.199
(
0.099)
0.000036
Gizzard
ND
N/
A
ND
N/
A
ND
N/
A
0.090
(
0.045)
0.000017
Liver
0.045
(
0.023)
0.00021
0.085
(
0.043)
0.00016
0.288
(
0.144)
0.00018
1.406
(
0.703)
0.00026
Eggs
0.031
(
0.016)
0.00015
0.071
(
0.036)
0.00013
0.225
(
0.133)
0.00016
1.188
(
0.594
0.00022
1.
Numbers
in
parentheses
refer
to
triadimenol
residue
levels
and
were
used
to
calculate
the
estimated
residues
at
1x
TDB.
It
is
assumed
that
one­
half
of
the
total
residues
found
is
due
to
triadimenol.
2.
Estimated
triadimenol
residues
=
(
total
dietary
contribution,
Table
6
/
feeding
level)
x
(
residue
from
feeding
studies;
residues
reported
at
less
than
the
LOD
of
0.01,
half
the
LOD
was
used).
3.
ND
=
Not
determined;
N/
A
=
Not
applicable.

The
maximum
residue
of
triadimenol
observed
in
any
matrix
in
the
poultry
feeding
study
was
liver
at
0.703
ppm
after
dosing
at
an
exaggerated
feeding
level
of
125
ppm
or
2720x
the
poultry
dietary
burden.
Based
on
the
2720x
dosing
level
for
poultry,
the
maximum
expected
residues
of
triadimenol
in
liver
at
a
1x
level
are
0.00026
ppm,
which
is
less
than
the
livestock
method
LOQ
of
0.05
ppm.

Triadimenol
is
not
registered
for
use
as
a
direct
livestock
treatment.
The
nature
of
the
residue
in
livestock
is
adequately
defined
for
the
current
uses.
HED
concludes
that
the
supported
registered
uses
on
barley,
corn,
cotton,
oats,
rye,
and
wheat
result
in
a
40
CFR
§
180.6(
a)(
3)
situation
for
ruminant
commodities;
i.
e.,
there
is
no
reasonable
expectation
of
finite
residues
in
ruminant
commodities.
Therefore,
additional
data
on
the
transfer
of
residues
to
meat,
milk,
poultry,
and
eggs
are
not
required
and
all
tolerances
for
livestock
commodities
should
be
revoked
pending
results
from
the
requested
corn
and
wheat
metabolism
studies.
If
registration
on
additional
commodities
and
livestock
feed
items
are
requested,
then
triazole
and
phenyl­
labeled
livestock
metabolism
studies
would
be
required.
Such
data
may,
in
turn,
trigger
the
need
for
magnitude
of
the
residue
(
feeding)
studies
in
livestock.

860.1500
Crop
Field
Trials
The
reregistration
requirements
for
magnitude
of
the
residue
in/
on
bananas
are
fulfilled.
Additional
field
trials
conducted
with
field
corn
(
forage,
grain,
stover),
sweet
corn
(
forage,
K+
CWHR,
grain,
and
stover),
cotton
(
undelinted
seed
and
gin
byproducts),
and
wheat
(
forage,
grain,
hay,
and
straw)
are
required
pending
the
results
from
the
requested
metabolism
studies.
Triadimenol
Summary
Analytical
Chemistry
and
Residue
Data
­
TRED
DP
Barcode:
314891
20
of
44
Currently,
triadimenol
is
registered
for
use
on
barley,
corn,
cotton,
oats,
rye,
sorghum,
and
wheat.
No
data
are
available
to
support
use
of
triadimenol
on
sorghum,
however,
Bayer
has
indicated
that
it
no
longer
intends
to
support
this
use.
Additionally,
an
import
tolerance
on
bananas
has
been
established.
Use
of
triadimenol
on
bananas
to
be
imported
into
the
U.
S.
is
supported
by
Bayer.
At
the
time
of
the
tolerance
petition,
Bayer
indicated
that
it
intended
to
register
triadimenol
products
for
use
on
bananas
in
Costa
Rice,
Guatemala,
Honduras,
and
Equador.

Details
of
any
required
label
amendments
are
presented
in
the
endnotes
for
860.1200
Directions
for
Use
and
respective
crop
sections
for
860.1500
Crop
Field
Trials
of
Table
5.
Refer
to
Tolerance
Reassessment
Summary
section
for
recommendations
with
respect
to
established
tolerance
levels.
Final
determination
of
the
adequacy
of
the
submitted
field
trial
data
for
barley,
corn,
cotton,
oats,
rye,
and
wheat
will
be
withheld
until
the
confirmatory
metabolism
data
is
submitted.

As
a
result
of
changes
to
Table
1
of
OPPTS
860.1000,
crop
field
trial
data
are
now
required
for
the
following
RACs
which
have
been
added
to
Table
1:
barley
hay,
cotton
gin
byproducts,
oat
hay,
and
wheat
hay.
Additionally,
field
trials
conducted
with
wheat
are
required
pending
the
results
from
the
requested
metabolism
studies.
The
required
field
trial
data
for
wheat
may
be
translated
to
barley,
rye,
and
oats.

Data
pertaining
to
triadimenol
residues
of
concern
in/
on
aspirated
grain
fractions
are
not
required
because
triadimenol
is
applied
as
a
seed
treatment.

Banana
(
MRID
40615201)

Data
submitted
reflect
eleven
field
trials
from
Costa
Rica
and
Honduras
in
which
soil
application
of
banana
groves
were
made
once
to
three
times
using
0.75
to
2.0
gm
ai/
pu
(
production
unit;
640­
800
production
units
grown
per
acre)
of
triadimenol
1%
or
3%
G.
The
use
rate
of
0.75
gm
ai/
pu
would
result
in
a
rate
of
1.06
to
1.32
lb
ai/
A.
Banana
samples
were
collected
and
frozen
for
a
maximum
of
180
days
prior
to
analysis
for
residues
of
triadimenol
and
KWG
1342
using
the
GC/
NPD
method
(
Report
No.
80488).
Pre­
harvest
intervals
(
PHIs)
ranged
from
0
to
203
days.
No
storage
stability
data
was
submitted
as
data
for
wheat
grain,
wheat
forage,
apples
and
grapes
showed
no
significant
loss
of
residues
after
two
years.
The
calculated
maximum
residue
in
whole
fruit
(
pulp
and
peel)
was
reported
at
0.14
ppm.
The
sample
reflects
one
application
using
1
gm
ai/
pu
with
a
203­
day
PHI.
Measurable
residues
of
triadimenol
and
KWG
1342
were
reported
in
the
pulp
and
peel
on
day
of
application
and
at
all
reported
PHIs
ranging
up
to
203
days.
The
bulk
of
residues
concentrate
in
peel,
almost
2
to
8
times
that
in
pulp,
depending
on
dosage
and/
or
number
of
applications.
Residues
in
the
pulp
did
not
exceed
0.075
ppm
at
all
dosages
and
PHIs
tested
(
up
to
2.7x
rate
and
203­
day
PHI).
At
the
1x
rate
of
0.75
gm
ai/
pu,
total
residues
in
whole
bananas
did
not
exceed
0.10
ppm,
reflecting
130­
day
PHI.
The
next
highest
level
was
0.09
ppm
reflecting
a
43­
day
PHI.
At
higher
rates,
two
residue
values
were
noted,
0.17
ppm
reflecting
a
2x
rate,
with
a
130­
day
PHI;
and
0.14
ppm
reflecting
a
1.3x
rate,
with
a
203­
day
PHI.
The
results
are
summarized
below
in
Table
9.
Triadimenol
Summary
Analytical
Chemistry
and
Residue
Data
­
TRED
DP
Barcode:
314891
21
of
44
Table
9.
Banana
Field
Trial
Residue
Data.

Applic.
rate
in
gm
ai/
pu
No
of
applic.
PHI
(
days)
Residues
(
ppm)

Pulp
Peel
Whole
Fruit2
Triadimenol
KWG
1342
Total
Triadimenol
KWG
1342
Total
Total
Site
COS­
BT005­
87D
0.75
(
1x)
1
0
0.01
0.03
0.04
0.03
0.05
0.08
0.05
0.75
(
1x)
1
14
ND1
ND
0.015
0.01
0.02
0.03
0.02
0.75
(
1x)
1
28
ND
ND
0.015
ND
ND
0.015
0.02
0.75
(
1x)
1
43
ND
0.02
0.025
ND
ND
0.015
0.02
0.75
(
1x)
1
51
ND
ND
0.015
ND
0.08
0.085
0.04
0.75
(
1x)
1
92
0.02
ND
0.03
0.03
ND
0.04
0.03
0.75
(
1x)
1
261
0.02
0.02
0.04
0.02
0.04
0.06
0.05
0.75
(
1x)
2
80
0.02
0.03
0.05
0.03
0.03
0.06
0.05
0.75
(
1x)
3
19
0.01
ND
0.02
0.03
0.03
0.06
0.03
0.75
(
1x)
3
130
0.04
ND
0.05
0.16
0.05
0.21
0.10
1.0
(
1.3x)
1
0
ND
ND
0.015
ND
ND
0.015
0.02
1.0
(
1.3x)
1
12
ND
ND
0.015
0.03
0.03
0.06
0.03
1.0
(
1.3x)
1
14
ND
ND
0.015
ND
ND
0.015
0.02
1.0
(
1.3x)
1
28
ND
0.02
0.025
ND
ND
0.015
0.02
1.0
(
1.3x)
1
43
0.06
0.03
0.09
ND
0.07
0.075
0.09
1.0
(
1.3x)
1
61
ND
0.07
0.075
ND
0.14
0.145
0.10
1.0
(
1.3x)
1
92
0.03
ND
0.04
0.03
ND
0.04
0.04
1.0
(
1.3x)
1
203
0.02
ND
0.03
0.03
0.05
0.08
0.05
1.5
(
2x)
3
130
0.03
ND
0.04
0.30
0.12
0.42
0.17
2.0
(
2.7x)
1
7
0.01
ND
0.02
0.03
0.04
0.07
0.04
2.0
(
2.7x)
1
35
ND
ND
0.015
0.01
0.03
0.04
0.02
2.0
(
2.7x)
1
49
ND
ND
0.015
0.01
0.04
0.05
0.03
2.0
(
2.7x)
1
63
ND
ND
0.015
0.05
0.04
0.09
0.04
2.0
(
2.7x)
1
79
0.01
ND
0.02
0.01
0.03
0.04
0.03
2.0
(
2.7x)
1
91
0.02
0.02
0.04
0.03
0.03
0.06
0.05
Site
HON­
BTEXT­
86
1.0
(
1.3x)
1
203
0.02
ND
0.03
0.30
0.05
0.35
0.14
1.0
(
1.3x)
1
203
0.01
ND
0.02
0.14
0.08
0.22
0.09
Site
COS­
BTEXT­
87H
1.0
(
1.3x)
1
35
ND
ND
0.015
0.02
0.03
0.05
0.03
1.0
(
1.3x)
1
49
ND
ND
0.015
0.01
0.03
0.025
0.02
Triadimenol
Summary
Analytical
Chemistry
and
Residue
Data
­
TRED
DP
Barcode:
314891
Table
9.
Banana
Field
Trial
Residue
Data.

Applic.
rate
in
gm
ai/
pu
No
of
applic.
PHI
(
days)
Residues
(
ppm)

Pulp
Peel
Whole
Fruit2
Triadimenol
KWG
1342
Total
Triadimenol
KWG
1342
Total
Total
22
of
44
1.0
(
1.3x)
1
63
ND
ND
0.015
0.01
0.03
0.04
0.02
1.0
(
1.3x)
1
79
ND
ND
0.015
0.02
0.03
0.05
0.03
1.0
(
1.3x)
1
91
0.02
ND
0.03
0.01
0.03
0.04
0.03
1.
ND
=
Not
detected
or
less
than
LOD.
One­
half
the
LOD
value
was
used;
0.005
ppm
for
triadimenol
and
0.01
ppm
for
KWG
1342,
for
calculating
total.
2.
Total
whole
fruit
was
calculated
based
on
a
2:
1
ratio
of
pulp
to
peel
([
total
pulp
residue
in
ppm
*
2/
3]
+
[
total
peel
residue
in
ppm
*
1/
3]).

These
data
indicate
that
the
combined
residues
of
triadimenol
and
KWG
1342
are
not
likely
to
exceed
the
established
tolerance
of
0.2
ppm
in/
on
bananas
following
application
at
the
maximum
registered
rate
of
0.75
gm
ai/
pu
with
a
0­
day
PHI.

Corn
(
MRIDs
00125407­
00125409)

Samples
were
obtained
from
crops
grown
in
MD,
MN,
NE,
TX,
FL,
IL,
MS,
IN,
KS,
GA,
OR,
and
Canada.
The
geographical
representation
is
considered
adequate
for
reregistration.
The
crops
were
grown
from
seed
treated
with
triadimenol
at
a
rate
of
1
oz
ai/
100
lbs
of
seed.
The
samples
were
analyzed
for
triadimenol
and
KWG
1342.
The
residues
in
various
components
were
as
follows:
green
forage,
<
0.01­
0.02
ppm
(
LOD
=
0.01)
with
PHIs
of
31­
146
days;
dry
forage,
<
0.01
ppm
with
PHIs
of
88­
159
days;
dry
kernels,
<
0.01
ppm
with
PHIs
of
88­
159
days;
dry
cob,
<
0.01
ppm
with
PHIs
of
88­
159
days;
dry
husks,
<
0.01
ppm
with
PHIs
of
88­
159
days;
milkstage
kernels,
<
0.01
ppm
with
PHIs
of
63­
146
days;
milk­
stage
cob,
<
0.01
ppm
with
PHIs
of
63­
146
days;
K+
CWHR,
<
0.01
ppm
with
PHIs
of
63­
146
days.

The
data
show
that
residues,
if
present,
in
grain,
forage,
or
fodder
of
field
corn,
popcorn,
and
sweet
corn
are
not
likely
to
exceed
the
established
tolerances
of
0.05
ppm
following
application
at
the
maximum
registered
rate
of
1
oz
ai/
100
lbs
of
seed.

Cotton
(
MRID
41242801)

Nine
crop
field
trials
were
conducted
on
cotton
seed
and
forage
in
five
states
(
AZ,
one
site;
CA,
4
sites;
MS,
two
sites;
OK,
one
site;
TX,
one
site).
The
geographical
representation
is
considered
adequate
for
reregistration.
All
studies
involved
a
single
seed
treatment
with
triadimenol
(
30%

FlC)
at
a
rate
of
3
oz
formulation/
100
lbs
of
seed
(
1
oz
ai/
100
lbs
of
seed).
At
all
locations,
treated
seeds
were
received
at
each
site
from
Gustafon
International
Research
Laboratory
in
TX
and
stored
at
room
temperature
under
cool,
dry
conditions
until
planting.
At
maturity,
the
raw
agricultural
commodities
cotton
seed
and
cotton
forage
were
randomly
harvested
by
hand
and
samples
were
shipped
frozen
to
Morse
Laboratories
in
Sacramento,
CA.
Upon
receipt,
samples
were
stored
in
a
freezer
at
#­
18
°
C
until
removed
for
sample
preparation
(
2­
10
weeks).
No
storage
stability
data
was
submitted
as
data
for
wheat
grain,
wheat
forage,
apples
and
grapes
Triadimenol
Summary
Analytical
Chemistry
and
Residue
Data
­
TRED
DP
Barcode:
314891
23
of
44
showed
no
significant
loss
of
residues
after
two
years.
The
samples
were
analyzed
for
triadimenol
and
KWG
1342
using
a
GC/
NPD
data­
collection
method
developed
by
Mobay
Chemical
Corporation.
The
reported
LOD
in
this
study
is
0.01
ppm
in
cotton
seed
and
forage.
The
recoveries
reported
for
fortified
samples
of
cotton
seed
(
0.02
ppm)
and
cotton
forage
(
0.5
ppm)
ranged
from
72
to
118%.
A
total
of
35
samples
were
analyzed
for
triadimenol
and
KWG
1342,
and
no
detectable
residues
were
found
in
either
cotton
seed
or
forage
at
harvest.

These
data
indicate
that
the
combined
residues
of
triadimenol
and
KWG
1342
are
not
likely
to
exceed
the
established
tolerance
of
0.02
ppm
in/
on
cotton
seed
following
application
at
the
maximum
registered
rate
of
1
oz
ai/
100
lbs
of
seed.
The
established
tolerance
for
cotton
forage
should
be
revoked
since
it
is
no
longer
considered
a
significant
livestock
feed
item.
Additionally,
field
trial
data
for
cotton
gin
byproducts
are
required.

Wheat
(
MRID
42712101)

Seven
crop
field
trials
were
conducted
on
spring
(
5)
and
winter
(
2)
seeded
wheat
in
seven
states
(
MN,
CA,
ID,
ND,
WA,
IN,
KS).
The
geographical
representation
is
considered
adequate
for
reregistration.
All
studies
involved
a
single
seed
treatment
with
triadimenol
(
Baytan
®
2.6
FS
Seed
Treatment
Fungicide)
at
a
rate
of
0.5
oz
ai/
100
lbs
of
seed.
Earliest
grazing
forage
and
earliest
harvest
grain
and
straw
samples
were
collected
and
analyzed
for
residues
of
triadimenol
and
KWG
1342
using
the
GC/
NPD
method
(
Report
No.
80488).
Pre­
harvest
intervals
(
PHIs)
ranged
from
33
to
196
days
for
forage
and
83­
296
days
for
grain
and
straw.
Samples
were
frozen
following
collection
and
shipped
to
Miles
Inc.
for
processing.
Forage,
hay
and
straw
samples
were
chopped
in
the
presence
of
dry
ice,
and
grain
samples
were
milled
while
frozen.
Samples
were
subsequently
frozen
and
transported
to
ABC
Laboratories,
Inc.,
Columbia,
Missouri.
All
samples
were
stored
frozen
prior
to
analysis.
The
results
are
summarized
below
in
Table
10.

Table
10.
Wheat
Field
Trial
Residue
Data.
1
Matrix
Location/
Field
Trial
ID
Variety
PHI
(
days)
2
Triadimenol
(
ppm)
KWG
1342
(
ppm)
Total
(
ppm)
3
Forage
MN/
251­
BT001­
89H
Spring
41
<
0.01
<
0.01
0.01
ND/
251­
BT002­
89H
Spring
33
0.03
<
0.01
0.035
ID/
452­
BT004­
89H
Spring
44
<
0.01
<
0.01
0.01
WA/
454­
BT006­
89H
Spring
47
0.03
<
0.01
0.035
CA/
457­
BT007­
89H
Spring
45
0.17
<
0.01
0.18
IN/
HIN­
BT008­
89H
Winter
196
0.03
<
0.01
0.035
KS/
STF­
BT009­
89H
Winter
68
0.03
<
0.01
0.035
Grain
MN/
251­
BT001­
89H
Spring
83
<
0.01
<
0.01
0.01
ND/
251­
BT002­
89H
Spring
90
<
0.01
<
0.01
0.01
ID/
452­
BT004­
89H
Spring
127
<
0.01
<
0.01
0.01
WA/
454­
BT006­
89H
Spring
108
<
0.01
<
0.01
0.01
IN/
HIN­
BT008­
89H
Winter
296
<
0.01
<
0.01
0.01
Triadimenol
Summary
Analytical
Chemistry
and
Residue
Data
­
TRED
DP
Barcode:
314891
Table
10.
Wheat
Field
Trial
Residue
Data.
1
Matrix
Location/
Field
Trial
ID
Variety
PHI
(
days)
2
Triadimenol
(
ppm)
KWG
1342
(
ppm)
Total
(
ppm)
3
24
of
44
KS/
STF­
BT009­
89H
Winter
286
<
0.01
0.02
0.025
Straw
MN/
251­
BT001­
89H
Spring
83
0.11
0.04
0.15
ND/
251­
BT002­
89H
Spring
90
<
0.01
<
0.01
0.01
ID/
452­
BT004­
89H
Spring
127
0.01
<
0.01
0.01
WA/
454­
BT006­
89H
Spring
108
<
0.01
<
0.01
0.01
IN/
HIN­
BT008­
89H
Winter
296
0.02
<
0.01
0.025
KS/
STF­
BT009­
89H
Winter
286
<
0.01
<
0.01
0.01
1.
Result
of
a
single
seed
treatment
application
at
approximately
0.5
oz
ai/
100
lbs
of
seed.
2.
Forage
samples
were
collected
at
earliest
grazing.
Grain
and
straw
samples
were
collected
at
earliest
harvest.
3.
Residues
with
reported
value
of
<
0.01
(
LOQ
=
0.01)
are
assigned
a
value
of
one­
half
the
LOQ
for
the
purpose
of
calculating
the
total
residue.

These
data
indicate
that
the
combined
residues
of
triadimenol
and
KWG
1342
are
not
likely
to
exceed
the
established
tolerances
of
0.05
ppm
in/
on
wheat
grain
and
0.2
ppm
in/
on
wheat
straw
following
application
at
the
maximum
registered
rate
of
0.5
oz
ai/
100
lbs
of
seed,
however,
the
established
tolerance
for
wheat
forage
is
too
high
and
should
be
reduced
to
0.5
ppm.

Barley
(
MRID
42696308)

Six
barley
field
trials
were
conducted
in
CA,
MN,
KS,
ID,
ND
and
WA
to
collect
residue
data
as
a
result
of
a
single
seed
treatment
application
of
triadimenol
(
Baytan
®
2.6
FS
Seed
Treatment
Fungicide)
at
a
rate
of
0.5
oz
ai/
100
lbs
of
seed.
The
geographical
representation
is
considered
adequate
for
reregistration.
Earliest
grazing
forage
and
earliest
harvest
grain
and
straw
samples
were
collected
and
analyzed
for
residues
of
triadimenol
and
KWG
1342
using
the
GC/
NPD
method
(
Report
No.
80488).
PHIs
ranged
from
33
to
68
days
for
forage
and
83­
282
days
for
grain
and
straw.
Samples
were
transported
to
Miles
Inc.
for
processing.
Forage
and
straw
samples
were
chopped
in
the
presence
of
dry
ice,
and
grain
samples
were
milled
while
frozen.
Samples
were
shipped
frozen
to
ABC
Laboratories,
Inc.,
Columbia,
Missouri
and
stored
frozen
prior
to
analysis.
The
analytical
results
reported
are
summarized
below
in
Table
11.

Table
11.
Barley
Field
Trial
Residue
Data.
1
Matrix
Location/
Field
Trial
ID
Variety
PHI
(
days)
2
Triadimenol
(
ppm)
KWG
1342
(
ppm)
Total
(
ppm)
3
Forage
MN/
251­
BT010­
89H
Spring
41
0.02
<
0.01
0.025
ND/
251­
BT011­
89H
Spring
33
0.02
<
0.01
0.025
ID/
452­
BT012­
89H
Spring
44
0.03
<
0.01
0.035
WA/
454­
BT014­
89H
Spring
47
0.03
<
0.01
0.035
CA/
457­
BT015­
89H
Spring
45
0.07
<
0.01
0.075
KS/
STF­
BT016­
89H
Winter
68
0.03
<
0.01
0.035
Triadimenol
Summary
Analytical
Chemistry
and
Residue
Data
­
TRED
DP
Barcode:
314891
Table
11.
Barley
Field
Trial
Residue
Data.
1
Matrix
Location/
Field
Trial
ID
Variety
PHI
(
days)
2
Triadimenol
(
ppm)
KWG
1342
(
ppm)
Total
(
ppm)
3
25
of
44
Grain
MN/
251­
BT010­
89H
Spring
83
0.02
<
0.01
0.025
ND/
251­
BT011­
89H
Spring
87
<
0.01
<
0.01
0.01
ID/
452­
BT012­
89H
Spring
110
<
0.01
<
0.01
0.01
WA/
454­
BT014­
89H
Spring
108
<
0.01
<
0.01
0.01
KS/
STF­
BT016­
89H
Winter
282
<
0.01
<
0.01
0.01
Straw
MN/
251­
BT010­
89H
Spring
83
0.05
0.05
<
0.01
<
0.01
0.055
0.055
ND/
251­
BT011­
89H
Spring
87
<
0.01
<
0.01
0.01
ID/
452­
BT012­
89H
Spring
110
<
0.01
0.01
0.015
WA/
454­
BT014­
89H
Spring
108
0.01
<
0.01
0.015
KS/
STF­
BT016­
89H
Winter
282
<
0.01
<
0.01
0.01
1.
Result
of
a
single
seed
treatment
application
at
approximately
0.5
oz
ai/
100
lbs
of
seed.
2.
Forage
samples
were
collected
at
earliest
grazing.
Grain
and
straw
samples
were
collected
at
earliest
harvest.
3.
Residues
with
reported
value
of
<
0.01
(
LOQ
=
0.01)
are
assigned
a
value
of
one­
half
the
LOQ
for
the
purpose
of
calculating
the
total
residue.

These
data
indicate
that
the
combined
residues
of
triadimenol
and
KWG
1342
are
not
likely
to
exceed
the
established
tolerances
of
0.05
ppm
in/
on
barley
grain
and
0.2
ppm
in/
on
barley
straw
following
application
at
the
maximum
registered
rate
of
0.5
oz
ai/
100
lbs
of
seed.

Oats
(
MRID
42696309)

Six
crop
field
trials
were
conducted
in
IA,
MN,
KS,
NY,
IN
and
WI
on
oats.
The
geographical
representation
is
considered
adequate
for
reregistration.
Each
study
involved
a
single
seed
treatment
with
triadimenol
(
Baytan
®
2.6
FS
Seed
Treatment
Fungicide)
at
a
rate
of
0.5
oz
ai/
100
lbs
of
seed.
Earliest
grazing
forage
and
earliest
harvest
grain
and
straw
samples
were
collected
and
analyzed
for
residues
of
triadimenol
and
KWG
1342
using
the
GC/
NPD
method
(
Report
No.
80488).
PHIs
ranged
from
35
to
73
days
for
forage
and
83­
122
days
for
grain
and
straw.
Samples
were
frozen
following
collection
and
shipped
to
Miles
Inc.
for
processing.
Forage,
hay
and
straw
samples
were
chopped
in
the
presence
of
dry
ice,
and
grain
samples
were
milled
while
frozen.
Samples
were
subsequently
frozen
and
transported
to
ABC
Laboratories,
Inc.,
Columbia,
Missouri.
All
samples
were
stored
frozen
prior
to
analysis.
The
results
are
summarized
below
in
Table
12.

Table
12.
Oat
Field
Trial
Residue
Data.
1
Matrix
Location/
Field
Trial
ID
PHI
(
days)
2
Triadimenol
(
ppm)
KWG
1342
(
ppm)
Total
(
ppm)
3
Forage
MN/
251­
BT­
017­
89H
41
0.01
<
0.01
0.015
IA/
255­
BT018­
89H
39
0.07
<
0.01
0.075
Triadimenol
Summary
Analytical
Chemistry
and
Residue
Data
­
TRED
DP
Barcode:
314891
Table
12.
Oat
Field
Trial
Residue
Data.
1
Matrix
Location/
Field
Trial
ID
PHI
(
days)
2
Triadimenol
(
ppm)
KWG
1342
(
ppm)
Total
(
ppm)
3
26
of
44
NY/
758­
BT019­
89H
35
0.26
<
0.01
0.27
WI/
851­
BT020­
89H
42
0.09
<
0.01
0.095
IN/
HIN­
BT021­
89H
53
0.14
<
0.01
0.15
KS/
STF­
BT022­
89H
73
<
0.01
<
0.01
0.01
Grain
MN/
251­
BT­
017­
89H
83
<
0.01
<
0.01
0.01
IA/
255­
BT018­
89H
92
<
0.01
<
0.01
0.01
NY/
758­
BT019­
89H
114
<
0.01
<
0.01
0.01
WI/
851­
BT020­
89H
98
<
0.01
<
0.01
0.01
IN/
HIN­
BT021­
89H
107
<
0.01
<
0.01
0.01
KS/
STF­
BT022­
89H
122
<
0.01
<
0.01
0.01
Straw
MN/
251­
BT­
017­
89H
83
0.02
<
0.01
0.025
IA/
255­
BT018­
89H
92
<
0.01
<
0.01
0.01
NY/
758­
BT019­
89H
114
<
0.01
<
0.01
0.01
WI/
851­
BT020­
89H
98
0.03
0.02
0.05
IN/
HIN­
BT021­
89H
107
<
0.01
<
0.01
0.01
KS/
STF­
BT022­
89H
122
<
0.01
0.02
0.025
1.
Result
of
a
single
seed
treatment
application
at
approximately
0.5
oz
ai/
100
lbs
of
seed.
2.
Forage
samples
were
collected
at
earliest
grazing.
Grain
and
straw
samples
were
collected
at
earliest
harvest.
3.
Residues
with
reported
value
of
<
0.01
(
LOQ
=
0.01)
are
assigned
a
value
of
one­
half
the
LOQ
for
the
purpose
of
calculating
the
total
residue.

These
data
indicate
that
the
combined
residues
of
triadimenol
and
KWG
1342
are
not
likely
to
exceed
the
established
tolerances
of
0.05
ppm
in/
on
oat
grain
and
0.2
ppm
in/
on
oat
straw
following
application
at
the
maximum
registered
rate
of
0.5
oz
ai/
100
lbs
of
seed,
however,
the
established
tolerance
for
oat
forage
is
too
high
and
should
be
reduced
to
0.5
ppm.

860.1520
Processed
Food/
Feed
The
reregistration
requirements
for
magnitude
of
the
residue
in
the
processed
commodities
of
field
corn
and
cotton
have
been
fulfilled.
Crop
field
trial
data
for
field
corn
(
MRID
44519801)
and
cotton
(
MRID
44519802)
indicate
that
residues
of
triadimenol,
KWG
1342,
and
KWG
1732
were
nonquantifiable
using
the
GC/
MS
method
(
Report
No.
106549)
following
treatment
at
5x
the
maximum
application
rate
of
1
oz
ai/
100
lbs
of
seed;
therefore,
processing
studies
for
these
commodities
were
not
conducted.

The
registrant
submitted
a
wheat
processing
study
(
MRID
44519803)
depicting
the
potential
for
concentration
of
triadimenol
residues
of
concern
in
wheat
processed
commodities
and
was
found
to
be
inadequate.
Wheat
seed
was
treated
with
the
2.65
lb/
gal
FlC
formulation
at
2.5
oz
ai/
100
Triadimenol
Summary
Analytical
Chemistry
and
Residue
Data
­
TRED
DP
Barcode:
314891
27
of
44
lbs
of
seed
(
5x
the
maximum
application
rate)
prior
to
planting.
The
treated
seed
was
planted
in
TX
18
days
after
treatment.
The
registrant
noted
that
the
treated
seed
did
not
grow
as
well
as
the
untreated
seed,
and
that
the
treated
plot
suffered
40­
50%
loss
due
to
winter
freezing
conditions.
One
sample
of
wheat
grain
grown
from
untreated
seed
and
two
samples
of
wheat
grain
grown
from
treated
seed
were
collected
at
maturity,
308
days
after
planting.
The
wheat
grain
samples
were
placed
in
frozen
storage
within
4
hours
of
collection,
and
then
shipped
frozen
to
the
analytical
laboratory
(
ABC
Laboratories,
Inc.),
where
they
were
stored
frozen
until
analysis.

Wheat
grain
samples
were
analyzed
for
residues
of
triadimenol,
KWG
1342,
and
KWG
1732
using
the
GC/
MS
method
(
Report
No.
106549).
Residues
were
below
the
LOQ
(<
0.05
ppm)
for
each
analyte
in/
on
one
sample
of
untreated
wheat
grain.
Residues
of
triadimenol
and
KWG
1342
were
below
the
LOQ
in/
on
two
samples
of
treated
wheat
grain.
Detectable
residues
of
KWG
1732
were
observed
in
the
wheat
grain
samples
at
0.11
and
0.23
ppm.

The
registrant
did
not
process
seed
from
the
above
5x
field
trial;
instead,
cited
a
wheat
processing
study
submitted
to
fulfill
reregistration
requirements
for
triadimefon
(
MRID
44029301).
In
that
study,
mature
wheat
grain
was
harvested
35
days
following
the
last
of
two
foliar
broadcast
applications
of
a
50%
WP
triadimefon
formulation
at
0.9
lb
ai/
A/
application
(
ca.
4x
the
maximum
seasonal
use
rate
for
triadimefon).
At
the
processing
facility
(
Texas
A&
M
University
Food
Protein
and
Development
Center,
Bryan,
TX),
aspirated
grain
fractions
were
collected
(
data
for
aspirated
grain
fractions
are
not
presented
here)
and
wheat
grain
samples
were
processed
into
bran,
wheat
germ,
flour,
middlings,
and
shorts,
using
a
small­
scale
processing
procedure
which
simulated
normal
commercial
processing
conditions.
These
data
indicate
that
the
combined
residues
of
triadimenol,
KWG
1342,
and
KWG
1732
concentrate
by
2.1x
in
wheat
bran
but
do
not
concentrate
in
wheat
flour,
middlings,
shorts,
or
germ.

The
available
wheat
grain
data
do
not
fulfill
the
requirement
for
a
wheat
grain
processing
study.
Residues
of
triadimenol
and
KWG
1342
were
each
<
LOQ
(<
0.05
ppm)
and
residues
of
KWG
1732
were
0.11
and
0.23
ppm
in/
on
two
samples
of
wheat
grain
grown
from
seed
treated
with
triadimenol
(
FlC)
at
5x
the
maximum
rate.
However,
the
treated
grain
was
not
processed.
Instead,
the
registrant
proposed
translating
data
from
a
triadimefon
wheat
grain
processing
study;
however,
these
data
cannot
be
translated
to
triadimenol
due
to
differences
in
the
use
patterns
(
seed
treatment
vs.
late
season
foliar
sprays)
that
are
likely
to
impact
the
potential
concentration
of
residues.
A
wheat
processing
study
conducted
with
triadimenol
applied
to
wheat
as
a
seed
treatment
should
be
submitted
once
the
requested
wheat
metabolism
studies
have
been
submitted
and
reviewed.

860.1650
Submittal
of
Analytical
Reference
Standards
An
analytical
reference
standard
for
triadimenol
was
submitted
by
Bayer
CropScience
in
November
of
2001
and
expires
November
of
2013.
The
standard
is
available
at
the
EPA
National
Pesticide
Standards
Repository.

860.1850
Confined
Accumulation
in
Rotational
Crops
and
860.1900
Field
Accumulation
in
Rotational
Crops
The
reregistration
requirements
for
accumulation
in
rotational
crops
are
fulfilled,
pending
results
Triadimenol
Summary
Analytical
Chemistry
and
Residue
Data
­
TRED
DP
Barcode:
314891
28
of
44
from
the
requested
wheat
and
corn
triazole
labeled
metabolism
studies.
With
the
available
data,
HED
concludes
that
the
metabolism
of
triadimenol
in
rotational
crops
(
root
crop,
leafy
vegetable,
and
grain
crop)
is
consistent
with
the
metabolism
investigated
in
the
primary
crop,
wheat.
Final
determination
of
the
metabolites
of
concern
will
be
withheld
until
the
requested
metabolism
studies
have
been
submitted
and
reviewed.
No
data
pertaining
to
confined/
field
accumulation
of
triadimenol
residues
in
rotational
crops
have
been
submitted.
Confined
rotational
crop
data
for
triadimefon
have
been
submitted
by
Bayer
(
S.
Knizner,
D186937,
MRID
42613301,
11/
3/
93).
The
study
successfully
characterized
and
identified
$
87%
of
the
total
14C­
residues
in/
on
all
crop
commodities.
Total
14C­
residues
exceeded
0.01
ppm
in/
on
the
commodities
of
wheat,
lettuce,
and
radish
that
were
planted
29,
161,
and
270
days
after
[
phenyl­
14C]
triadimefon
was
applied
at
5.8
lb
ai/
A.
The
uptake
of
residues
was
lowest
in
radish
bulbs
(
0.30
ppm)
and
highest
in
wheat
straw/
chaff
(
38.46
ppm).
The
pattern
of
accumulation
in
relation
to
rotation
intervals
could
not
readily
be
established
in
radish
commodities;
accumulation
was
highest
at
the
29­
day
rotation
and
declined
in
subsequent
intervals,
but
in
lettuce
and
wheat
commodities,
accumulation
was
lowest
at
the
29­
day
rotation
and
increased
thereafter.
Triadimefon
was
identified
and
quantified
as
a
minor
residue
(#
4%
of
TRR)
in/
on
the
organosoluble
fractions
of
all
commodities,
except
in
wheat
grain
where
the
parent
was
below
the
limit
of
detection
(
0.0072
ppm).
The
principal
metabolites
identified
in
leafy
commodities
and
radish
bulbs
were
triadimenol
and
its
acetylated
or
glucoside
derivatives;
collectively,
these
metabolites
accounted
for
93%
of
TRR
in
29­
DAT
lettuce,
67%
of
TRR
in
161­
DAT
wheat
straw
and
270­
DAT
immature
wheat
or
wheat
forage,
and
87%
of
TRR
in
radish
bulbs.
In
wheat
grain,
the
predominant
compound
identified
was
KWG
1732
which
comprised
63­
91%
of
TRR.

Based
on
this
study,
the
Agency
required
limited
field
rotational
crop
studies
for
triadimefon.
Subsequently,
Bayer
requested
deletion
of
all
rotatable
crop
uses
from
its
triadimefon
product
labels.

The
available
confined
rotational
crop
data
for
triadimefon
indicate
a
potential
for
accumulation
of
triadimenol
residues
of
concern
in/
on
rotatable
crops.
However,
the
application
rate
used
in
the
study
is
much
greater
than
the
expected
"
application"
rate
resulting
from
application
of
triadimenol
to
seed.
In
recently
submitted
triadimenol
processing
studies
(
MRID
44519801­
44519803),
treated
seed
was
planted
at
the
rate
of
13
lb
of
seed/
acre
(
field
corn),
16
lb/
acre
(
cotton),
and
91
lb/
acre
(
wheat).
Based
on
maximum
application
rates
of
0.062
lb
ai
per
100
lb
of
seed
for
corn
and
cotton
and
0.031
lb
per
100
lb
of
seed
for
wheat,
the
equivalent
"
soil
application"
rates
would
be
approximately
0.01
lb
ai/
A
for
corn
and
cotton,
and
0.03
lb
ai/
A
for
wheat.
Therefore,
the
application
rate
of
the
triadimefon
rotational
crop
study
is
approximately
190x
the
maximum
triadimenol
rate
for
annual
crops.
If
the
highest
residue
found
in
rotational
crops,
19.0
ppm
triadimenol
in
wheat
straw,
is
"
corrected"
down
to
a
1x
application,
expected
residues
would
be
0.1
ppm,
which
is
greater
than
0.01
ppm.
Therefore,
the
Agency
concludes
that
limited
field
rotational
crop
studies
for
triadimenol
must
be
submitted
pending
the
results
from
the
requested
metabolism
studies.

Tolerance
Reassessment
Summary
Tolerances
for
residues
in/
on
plant
and
livestock
commodities
are
established
under
40
CFR
§
180.450.
Tolerances
for
plant
commodities
are
established
under
40
CFR
§
180.450
(
a)
and
are
currently
expressed
in
terms
of
the
combined
residues
of
triadimenol
[$­(
4­
chlorophenoxy)­"­
Triadimenol
Summary
Analytical
Chemistry
and
Residue
Data
­
TRED
DP
Barcode:
314891
29
of
44
(
1,1­
dimethylethyl)­
1H­
1,2,4­
triazole­
1­
ethanol]
and
its
butanediol
metabolite
[
4­(
4­
chlorophenoxy)­
2,2­
dimethyl­
4­(
1H­
1,2,4­
triazol­
1­
yl)­
1,3­
butanediol],
calculated
as
triadimenol.
Tolerances
for
livestock
commodities
are
established
under
40
CFR
§
180.450
(
b)
and
are
currently
expressed
in
terms
of
the
combined
residues
triadimenol
and
its
metabolites
containing
the
chlorophenoxy
moiety,
calculated
as
triadimenol.

The
listing
of
triadimenol
tolerances
under
40
CFR
§
180.450
should
be
subdivided
into
parts
(
a),
(
b),
(
c),
and
(
d).
Part
(
a)
should
be
reserved
for
commodities
with
permanent
tolerances,
part
(
b)
for
Section
18
emergency
exemptions,
part
(
c)
for
tolerances
with
regional
registrations,
and
part
(
d)
for
indirect
or
inadvertent
residues.
In
addition,
the
tolerance
expression
for
plant
commodities
should
be
revised
to
state
that
combined
residues
are
"
expressed
as
triadimenol"
and
not
"
calculated
as
triadimenol."
The
reorganization
of
triadimenol
tolerances
should
be
conducted
as
depicted
below
in
Table
13.

Table
13.
Reorganization
of
Triadimefon
Tolerances
Required
Under
40
CFR.

40
CFR
Section
Reserved
For
Tolerance
Expression
§
180.450(
a)(
1)
barley,
corn,
cotton,
oats,
rye,
and
wheat
Tolerances
are
established
for
the
combined
residues
of
the
fungicide
$­(
4­
chlorophenoxy)­"­(
1,1­
dimethylethyl)­
1H­
1,2,4­
triazole­
1­
ethanol
[
triadimenol],
1­(
4­
chlorophenoxy)­
3,3­
dimethyl­
3­
hydroxymethyl­
1­(
1H­
1,2,4­
triazol­
1­
yl)­
2­
butanol
[
KWG
1342],
and
1­(
4­
chlorophenoxy)­
1­(
1H­
1,2,4­
triazol­
1­
yl)
ethanoic
acid
[
KWG
1732],
expressed
as
triadimenol,
in
or
on
the
following
raw
agricultural
commodities:

§
180.450(
a)(
2)
banana
Tolerances
are
established
for
the
combined
residues
of
the
fungicide
$­(
4­
chlorophenoxy)­"­(
1,1­
dimethylethyl)­
1H­
1,2,4­
triazole­
1­
ethanol
[
triadimenol]
and
1­(
4­
chlorophenoxy)­
3,3­
dimethyl­
3­
hydroxymethyl­
1­(
1H­
1,2,4­
triazol­
1­
yl)­
2­
butanol
[
KWG
1342],
expressed
as
triadimenol,
in
or
on
the
following
raw
agricultural
commodities:

The
Agency
has
updated
the
list
of
raw
agricultural
and
processed
commodities
and
feedstuffs
derived
from
crops
(
Table
1,
OPPTS
860.1000).
As
a
result
of
changes
to
Table
1,
tolerances
are
now
required
for
RACs
which
have
been
added
to
Table
1.
Also,
some
commodity
definitions
must
be
corrected.
A
summary
of
triadimenol
tolerance
reassessments
is
presented
in
Table
14.

Tolerances
Established
Under
40
CFR
§
180.450(
a)

Sufficient
field
trial
data
reflecting
the
maximum
label
use
pattern
are
available
to
reassess
the
established
tolerance
for
bananas.

Insufficient
data
are
available
to
ascertain
the
adequacy
of
the
established
tolerances
for
the
following:
field
corn
(
forage,
grain,
stover),
sweet
corn
(
forage,
K+
CWHR,
grain,
and
stover),
cotton
(
undelinted
seed
and
gin
byproducts),
and
wheat
(
forage,
grain,
hay,
and
straw).
Final
data
requirements
for
these
commodities
will
be
withheld
until
the
required
corn
and
wheat
metabolism
studies
are
submitted
and
reviewed.
The
required
field
trial
data
for
wheat
may
be
translated
to
barley,
rye,
and
oats.
Triadimenol
Summary
Analytical
Chemistry
and
Residue
Data
­
TRED
DP
Barcode:
314891
30
of
44
The
established
tolerance
for
cotton
forage
should
be
revoked
because
this
commodity
is
no
longer
considered
a
significant
livestock
feed
item.

Tolerances
To
Be
Proposed
Under
40
CFR
§
180.450(
a)

Because
of
changes
to
Table
1
(
OPPTS
860.1000),
tolerances
for
barley
hay,
cotton
gin
byproducts,
oat
hay,
and
wheat
hay
must
be
proposed.
There
are
no
data
available
for
wheat
hay
reflecting
application
according
to
the
currently
registered
use
pattern.
The
required
data
for
wheat
hay
will
be
translated
to
barley
and
oat
hay.

Tolerances
Established
Under
40
CFR
§
180.450(
b)

Acceptable
feeding
studies
for
ruminants
and
poultry
are
available
to
reassess
the
tolerances
for
the
livestock
commodities.

Triadimenol
is
not
registered
for
use
as
a
direct
livestock
treatment.
The
nature
of
the
residue
in
livestock
is
adequately
defined
for
the
current
uses.
HED
concludes
that
the
supported
uses
on
barley,
corn,
cotton,
oats,
rye,
and
wheat
result
in
a
40
CFR
§
180.6(
a)(
3)
situation
for
ruminant
commodities;
i.
e.,
there
is
no
reasonable
expectation
of
finite
residues
in
ruminant
commodities.
Therefore,
additional
data
on
the
transfer
of
residues
to
meat,
milk,
poultry,
and
eggs
are
not
required
and
all
tolerances
for
livestock
commodities
should
be
revoked.

Table
14.
Tolerance
Reassessment
Summary
for
Triadimenol.

Commodity
Current
Tolerance,
ppm
Reassessed
Tolerance,
ppm
Comment
[
Correct
Commodity
Definition]

Tolerances
Established
Under
40
CFR
§
180.450
(
a)

Banana
(
whole)
1
0.2
0.2
Barley,
grain
0.05
TBD2
Barley,
straw
0.2
TBD
Corn,
forage
0.05
TBD
[
Corn,
field,
forage]
[
Corn,
sweet,
forage]

Corn,
fresh
(
including
sweet),
(
K+
CWHR)
0.05
TBD
[
Corn,
sweet,
K+
CWHR]

Corn,
grain
0.05
TBD
[
Corn,
field,
grain]
[
Corn,
pop,
grain]

Corn,
stover
0.05
TBD
[
Corn,
field,
stover]
[
Corn,
pop,
stover]
[
Corn,
sweet,
stover]

Cotton,
forage
0.02
Revoke
No
longer
considered
a
significant
livestock
feed
item.

Cotton,
undelinted
seed
0.02
TBD
Oat,
forage
2.5
TBD
Triadimenol
Summary
Analytical
Chemistry
and
Residue
Data
­
TRED
DP
Barcode:
314891
Table
14.
Tolerance
Reassessment
Summary
for
Triadimenol.

Commodity
Current
Tolerance,
ppm
Reassessed
Tolerance,
ppm
Comment
[
Correct
Commodity
Definition]

31
of
44
Oat,
grain
0.05
TBD
Oat,
straw
0.2
TBD
Rye,
forage
2.5
TBD
Rye,
grain
0.05
TBD
Rye,
straw
0.1
TBD
Sorghum,
forage,
hay
0.05
Revoke
Bayer
does
not
intend
to
support
use
of
triadimenol
on
sorghum.

Sorghum,
grain
0.01
Revoke
Bayer
does
not
intend
to
support
use
of
triadimenol
on
sorghum.

Sorghum,
grain,
stover
0.01
Revoke
Bayer
does
not
intend
to
support
use
of
triadimenol
on
sorghum.

Wheat,
forage
2.5
TBD
Wheat,
grain
0.05
TBD
Wheat,
straw
0.2
TBD
Tolerances
Established
Under
40
CFR
§
180.450
(
b)

Cattle,
fat
0.1
Revoke
The
available
data
indicate
that
tolerances
for
cattle
commodities
are
not
required.
Cattle,
meat
0.1
Cattle,
meat
byproducts
0.1
Egg
0.01
Revoke
The
available
data
indicate
that
a
tolerance
for
eggs
is
not
required.

Goat,
fat
0.1
Revoke
The
available
data
indicate
that
tolerances
for
goat
commodities
are
not
required.
Goat,
meat
0.1
Goats,
meat
byproducts
0.1
Hog,
fat
0.1
Revoke
The
available
data
indicate
that
tolerances
for
hog
commodities
are
not
required.
Hog,
meat
0.1
Hog,
meat
byproducts
0.1
Horse,
fat
0.1
Revoke
The
available
data
indicate
that
tolerances
for
horse
commodities
are
not
required.
Horse,
meat
0.1
Horse,
meat
byproducts
0.1
Milk
0.01
Revoke
The
available
data
indicate
that
a
tolerance
for
milk
is
not
required.
Triadimenol
Summary
Analytical
Chemistry
and
Residue
Data
­
TRED
DP
Barcode:
314891
Table
14.
Tolerance
Reassessment
Summary
for
Triadimenol.

Commodity
Current
Tolerance,
ppm
Reassessed
Tolerance,
ppm
Comment
[
Correct
Commodity
Definition]

32
of
44
Poultry,
fat
0.01
Revoke
The
available
data
indicate
that
tolerances
for
poultry
commodities
are
not
required.
Poultry,
meat
0.01
Poultry,
meat
byproducts
0.01
Sheep,
fat
0.1
Revoke
The
available
data
indicate
that
tolerances
for
sheep
commodities
are
not
required.
Sheep,
meat
0.1
Sheep,
meat
byproducts
0.1
Tolerances
To
Be
Proposed
Under
40
CFR
§
180.450
(
a)

Barley,
hay
None
established
TBD
Cotton,
gin
byproducts
None
established
TBD
Oat,
hay
None
established
TBD
Wheat,
hay
None
established
TBD
1.
40
CFR
§
180.450(
a)
states
that
there
are
no
U.
S.
registrations
for
banana
(
whole)
as
of
9/
22/
93.
2.
TBD
=
To
be
determined.

Codex
Harmonization
The
Codex
Alimentarius
Commission
(
Codex)
has
established
several
maximum
residue
limits
(
MRLs)
for
triadimenol
in/
on
various
raw
agricultural
commodities.
The
Codex
MRLs
are
expressed
in
terms
of
triadimenol
per
se.
The
MRLs
have
been
established
to
accommodate
triadimenol
residues
resulting
from
the
use
of
triadimefon
and/
or
triadimenol.
Compatibility
cannot
be
achieved
with
the
Codex
MRLs
because
these
levels
are
expressed
in
terms
of
triadimenol
only;
the
U.
S.
tolerances
for
plant
commodities
are
expressed
in
terms
of
triadimenol,
KWG
1342,
and
KWG
1732
in/
on
cereal
grains
and
cotton
and
triadimenol
and
KWG
1342
in/
on
bananas.
Additionally,
all
U.
S.
livestock
tolerances
should
be
revoked.
A
numerical
comparison
of
the
Codex
MRLs
and
the
corresponding
reassessed
U.
S.
tolerances
is
presented
in
Table
15.

Table
15.
Codex
MRLs
for
Triadimenol
and
Applicable
U.
S.
Tolerances.

Codex
Reassessed
U.
S.
Tolerance
(
ppm)
CODEX
Comments
Commodity
(
As
Defined)
MRL1
(
mg/
kg)
Step
Artichoke
globe
1
CXL
­­
2
Source
of
data:
triadimefon,
triadimenol
Banana
0.2
CXL
0.2
Source
of
data:
triadimenol
Barley
0.5
CXL
TBD3
Source
of
data:
triadimefon,
triadimenol
Barley
straw
and
fodder,
Dry
5
CXL
TBD
Source
of
data:
triadimefon,
triadimenol
Triadimenol
Summary
Analytical
Chemistry
and
Residue
Data
­
TRED
DP
Barcode:
314891
Table
15.
Codex
MRLs
for
Triadimenol
and
Applicable
U.
S.
Tolerances.

Codex
Reassessed
U.
S.
Tolerance
(
ppm)
CODEX
Comments
Commodity
(
As
Defined)
MRL1
(
mg/
kg)
Step
33
of
44
Chick­
pea
(
dry)
0.05
(*)
CXL
­­
2
Source
of
data:
triadimefon
Coffee
beans
0.1
(*)
CXL
­­
2
Source
of
data:
triadimefon,
triadimenol
Currants,
Black,
Red,
White
0.5
CXL
­­
2
Source
of
data:
triadimefon
Eggs
0.05
(*)
CXL
Revoke
Source
of
data:
triadimefon,
triadimenol
Fodder
beet
0.05
(*)
CXL
­­
2
Source
of
data:
triadimefon
Fodder
beet
leaves
or
tops
0.2
CXL
­­
2
Source
of
data:
triadimefon
Fruiting
vegetables,
Cucurbits
2
CXL
­­
2
Source
of
data:
triadimefon,
triadimenol
Grapes
2
CXL
­­
2
Source
of
data:
triadimefon,
triadimenol
Hops,
Dry
5
CXL
­­
2
Source
of
data:
triadimefon
Mango
0.05
(*)
CXL
­­
2
Source
of
data:
triadimefon
Meat
(
from
mammals
other
than
marine
mammals)
0.05
(*)
CXL
Revoke
Source
of
data:
triadimefon,
triadimenol
Milks
0.01
(*)
CXL
Revoke
Source
of
data:
triadimefon,
triadimenol
Oat
straw
and
fodder,
Dry
5
CXL
TBD
Source
of
data:
triadimefon,
triadimenol
Oats
0.2
CXL
TBD
Source
of
data:
triadimefon,
triadimenol
Onion,
Welsh
0.05
(*)
CXL
­­
2
Source
of
data:
triadimefon,
triadimenol
Peas
(
pods
and
succulent=
immature
seeds)
0.1
CXL
­­
2
Source
of
data:
triadimefon
Peppers,
Sweet
0.1
CXL
­­
2
Source
of
data:
triadimefon
Pineapple
1
2
CXL
­­
2
Source
of
data:
triadimefon
Pome
fruits
0.5
CXL
­­
2
Source
of
data:
triadimefon,
triadimenol
Poultry
meat
0.05
(*)
CXL
Revoke
Source
of
data:
triadimefon,
triadimenol
Raspberries,
Red,
Black
0.5
CXL
­­
2
Source
of
data:
triadimefon
Rye
0.2
CXL
TBD
Source
of
data:
triadimefon,
triadimenol
Rye
straw
and
fodder,
Dry
5
CXL
TBD
Source
of
data:
triadimefon,
triadimenol
Spring
onion
0.05
(*)
CXL
­­
2
Source
of
data:
triadimefon
Strawberry
0.1
CXL
­­
2
Source
of
data:
triadimefon
Sugar
beet
0.1
(*)
CXL
­­
2
Source
of
data:
triadimefon,
triadimenol
Sugar
beet
leaves
or
tops
1
CXL
­­
2
Source
of
data:
triadimefon,
triadimenol
Triadimenol
Summary
Analytical
Chemistry
and
Residue
Data
­
TRED
DP
Barcode:
314891
Table
15.
Codex
MRLs
for
Triadimenol
and
Applicable
U.
S.
Tolerances.

Codex
Reassessed
U.
S.
Tolerance
(
ppm)
CODEX
Comments
Commodity
(
As
Defined)
MRL1
(
mg/
kg)
Step
34
of
44
Tomato
0.5
CXL
­­
2
Source
of
data:
triadimefon
Wheat
0.2
CXL
TBD
Source
of
data:
triadimefon,
triadimenol
Wheat
straw
and
fodder,
Dry
5
CXL
TBD
Source
of
data:
triadimefon,
triadimenol
1.
Asterisk
designates
MRL
set
at
the
limit
of
quantitation.
2.
The
basic
producer
does
not
have
registered
uses
of
triadimenol
on
this
commodity.
3.
TBD
=
To
be
determined;
crop
field
trial
data
requirements
remain
outstanding.

Bibliography
Agency
Memoranda
Citations
CB
No.:
None
Subject:
PP#
3F2854:
Baytan
 
on
Small
Grains.
Evaluation
of
residue
data
and
analytical
method.
From:
A.
Smith
To:
H.
Jacoby
and
Toxicology
Branch
Dated:
8/
1/
83
MRID:
None
CB
No.:
None
Subject:
PP#
3F2854:
Baytan
 
on
Small
Grains.
Amendment
of
8/
23/
93.
From:
A.
Smith
To:
H.
Jacoby
and
Toxicology
Branch
Dated:
1/
4/
84
MRID:
None
CB
Nos.:
4887,
4888,
4889,
and
4890
Subject:
PP#'
s
3F2854,
4F3155,
5F3224,
and
FAP#
5H5458;
Baytan
Multiresidue
Method
Trial.
From:
E.
Haeberer
To:
L.
Rossi
and
Toxicology
Branch
Dated:
2/
23/
89
MRID:
40969801
CB
No.:
5221
Subject:
PP8E3642:
Triadimenol
(
Baytan
or
BAY
KWG
0519)
on
Imported
Bananas.
Letter
of
March
28,
1989.
From:
S.
Malak
To:
L.
Rossi
and
Toxicology
Branch
Dated:
5/
16/
89
MRID:
41051401
DP
Barcode:
None
Subject:
Multiresidue
Methods.
From:
L.
Edwards
To:
L.
Sawyer,
FDA
Dated:
6/
30/
92
MRID:
41976001
Triadimenol
Summary
Analytical
Chemistry
and
Residue
Data
­
TRED
DP
Barcode:
314891
35
of
44
DP
Barcodes:
D168542
and
D178884
Subject:
Triadimefon
(
109901):
Storage
Stability
Data,
PAM
Multiresidue
Methods,
Product
Chemistry
Data.
CBRS
Nos.
8566
and
9929.
From:
S.
Hummel
To:
M.
Wilhite/
B.
Sidwell
Dated:
12/
22/
92
MRIDs:
41976601,
41976602,
and
42307801­
42307803
DP
Barcode:
D174151
Subject:
Triadimefon.
List
B
Reregistration
Case
No.
2700/
Chemical
ID
No.
109901.
Raw
data
to
upgrade
metabolism
studies
reviewed
in
Phase
4.
Phase
5
Review
of
subject
studies.
CBRS
No.
9422.
From:
C.
Swartz
To:
B.
Sidwell
Dated:
9/
23/
92
MRIDs:
42123400­
42123404
DP
Barcode:
None
Subject:
PP8E3642:
Triadimenol
(
Baytan)
on
Imported
Bananas.
Comments
on
Draft
Federal
Register
Notice.
CBTS
#
12171
From:
M.
Rodriguez
To:
C.
Giles­
Parker
Dated:
7/
20/
93
MRID:
None
DP
Barcode:
D194981
Subject:
PP8E3642:
Triadimenol
(
Baytan)
on
Imported
Bananas.
Amendment
dated
August
25,
1993.
Optical
Configurations
and
Activities
of
Active
Ingredient
Isomers.
(
Response
to
CBTS
#
12171,
July
20,
1993).
CBTS
#
12533
From:
M.
Rodriguez
To:
C.
Giles­
Parker/
J.
Stone
Dated:
9/
23/
93
MRID:
None
DP
Barcode:
D194719
Subject:
Triadimefon.
List
B
Reregistration
Case
No.
2700/
Chemical
ID
No.
109901.
Submission
of
Raw
Data
to
Upgrade
Cucumber
and
Tomato
Metabolism
Studies.
CBRS
No.
12515
From:
C.
Swartz
To:
B.
Sidwell
Dated:
10/
20/
93
MRIDs:
42798900
and
42798901
DP
Barcode:
D194783
Subject:
Triadimefon.
Storage
Stability
Study.
Reregistration
Case
No.
2700.
Chemical
No.
109901.
CBRS
#
12528.
From:
Steven
A.
Knizner
To:
M.
Wilhite
Dated:
11/
7/
93
MRID:
42857401
DP
Barcode:
D194786
Subject:
Triadimefon.
Poultry
Metabolism
Study.
Reregistration
Case
No.
2700.
Chemical
No.
109901.
CBRS
#
12530.
From:
Steven
A.
Knizner
To:
M.
Wilhite
Dated:
11/
2/
93
MRID:
42864901
Triadimenol
Summary
Analytical
Chemistry
and
Residue
Data
­
TRED
DP
Barcode:
314891
36
of
44
DP
Barcode:
D194819
Subject:
Triadimefon.
Ruminant
Metabolism
Study.
Reregistration
Case
No.
2700.
Chemical
No.
109901.
CBRS
#
12514.
From:
Steven
A.
Knizner
To:
M.
Wilhite
Dated:
11/
2/
93
MRID:
42856801
DP
Barcode:
D186937
Subject:
Triadimefon.
Confined
Rotational
Crop
Study.
Reregistration
Case
No.
2700.
Chemical
No.
109901.
CBRS
#
11212.
From:
Steven
A.
Knizner
To:
M.
Wilhite
Dated:
11/
3/
93
MRID:
42613301
DP
Barcode:
D194676
Subject:
Triadimefon.
Wheat
Metabolism
Study.
Reregistration
Case
No.
2700.
Chemical
No.
109901.
CBRS
#
12527.
From:
Steven
A.
Knizner
To:
M.
Wilhite
Dated:
11/
3/
93
MRID:
42853401
DP
Barcode:
D189881
Subject:
ID#:
003125­
UEU.
Triadimenol
(
Baytan
2.6
FS)
for
Use
as
a
Seed
Treatment
in
or
on
Wheat,
Barley,
and
Oats.
Evaluation
of
Analytical
Method
and
Magnitude
of
the
Residue
Data.
CBTS
No.
11690.
From:
D.
Davis
To:
J.
Stone/
C.
Giles­
Parker
and
J.
Fleuchaus
Dated:
11/
3/
93
MRIDs:
42696308,
42696309,
42712101
DP
Barcode:
None
Subject:
Triadimefon.
Addendum
to
Wheat,
Ruminant,
and
Poultry
Metabolism
Studies
and
Confined
Rotational
Crop
Study.
Reregistration
Case
No.
2700.
Chemical
No.
109901.
From:
Steven
A.
Knizner
To:
M.
Wilhite
Dated:
12/
9/
93
MRIDs:
42853401,
42856801,
42864901,
and
42613301
DP
Barcode:
D199645
Subject:
PP#
4F04320.
Triadimenol
for
Use
as
a
Seed
Treatment
in
or
on
Wheat,
Barley,
and
Oats.
Proposed
Increase
in
Tolerances
for
Straw.
Evaluation
of
Analytical
Method
and
Magnitude
of
the
Residue
Data.
CBTS
No.
13268.
From:
D.
Davis
To:
J.
Stone/
C.
Giles­
Parker
Dated:
3/
7/
94
MRID:
None
Triadimenol
Summary
Analytical
Chemistry
and
Residue
Data
­
TRED
DP
Barcode:
314891
37
of
44
DP
Barcode:
D208890
Subject:
Triadimefon.
Data
Submitted
to
Upgrade
Ruminant
and
Poultry
Metabolism
Studies
and
Analysis
of
Tissues
from
Metabolism
Study
with
Analytical
Enforcement
Method.
Reregistration
Case
No.
2700.
Chemical
No.
109901.
CBRS
#
14659
From:
Steven
A.
Knizner
To:
M.
Wilhite
Dated:
12/
16/
94
MRIDs:
43418301,
43418302,
and
43418303
DP
Barcode:
D210160
Subject:
Triadimefon.
Meat,
Milk,
Eggs
Storage
Stability
Study.
Reregistration
Case
No.
2700.
Chemical
No.
109901.
CBRS
#
14826
From:
S.
Knizner
To:
M.
Wilhite
Dated:
2/
23/
95
MRID:
43462401
DP
Barcodes:
D227403,
D227497,
D227543
Subject:
Residue
Analytical
Methods,
Storage
Stability
Data
From:
J.
Punzi
To:
B.
Chambliss
Dated:
7/
13/
00
MRIDs:
43870101,
44038901,
44041001,
44041002
DP
Barcode:
None
DEB
No.:
5865
Subject:
PP#
9F3802.
Triadimenol
in
or
on
cotton
seed
and
cotton
forage.
From:
L.
Rodriquez
To:
S.
Lewis
Dated:
3/
12/
1990
MRID:
41242801
DP
Barcode:
D322304
Subject:
Triadimenol.
Field
Corn,
Cotton,
and
Wheat
Processing
Studies
From:
S.
Ary
To:
R.
Griffin
Dated:
10/
14/
2005
MRIDs:
44519801­
44519803
DP
Barcode:
D314742
Subject:
Triadimefon.
Summary
of
Analytical
Chemistry
and
Residue
Data
for
the
Reregistration
Eligibility
Decision
(
RED)
Document.
From:
S.
Ary
To:
R.
Griffin
and
J.
Pates
Dated:
11/
23/
2005
MRID:
None
Master
Record
Identification
Numbers
00125407
Mobay
Chemical
Corp.
(
1982)
Baytan:
Residues
in
Wheat
and
Other
Crops.
(
Compilation;
unpublished
study
received
Mar
11,
1983
under
3125­
346;
CDL:
071462­
I).

00125408
Mobay
Chemical
Corp.
(
1982)
Baytan:
Residue
Chemistry
on
Corn:
Document
No.
AS
83­
320.
(
Compilation;
unpublished
study
received
Mar
11,
1983
under
3125­
346;
CDL:
071463­
A).
Triadimenol
Summary
Analytical
Chemistry
and
Residue
Data
­
TRED
DP
Barcode:
314891
38
of
44
00125409
Mobay
Chemical
Corp.
(
1982)
Baytan:
Residue
Chemistry
on
Cereal
Crops:
Brochure
No.
1152.
(
Compilation;
unpublished
study
received
Mar
11,
1983
under
3125­
346;
CDL:
071464­
A;
071465).

40615201
Pither,
K.
(
1988)
Triadimenol­­
Magnitude
of
Residues
on
Bananas:
Baytan
Objective
No.
5781.
Unpublished
study
prepared
by
PTRL.
86
p.

40969801
Foushee,
G.
(
1988)
Baytan,
Multiresidue
Method
Trial:
Project
ID;
87­
4705;
Mobay
Report
No.
95672.
Unpublished
study
prepared
by
Langston
Laboratory,
Inc.
526
p.

41051401
Pither,
K.
(
1989)
Triadimenol­­
Magnitude
of
Residues
on
Bananas:
Baytan
Objective
No.
5781:
Mobay
Report
No.
95684­
1.
Unpublished
study
prepared
by
PTRL.
11
p.

41242801
Rockwell,
J.
(
1988)
Residues
of
Baytan
and
Its
Metabolites
in
Cotton:
Morse
Laboratories
45659,
45661.
Unpublished
study
prepared
by
Morse
Laboratories.
354
p.

41976601
Ver
Hey,
M.
(
1991)
Bayleton,
KWG
1323
and
KWG
1342:
Multiresidue
Method
Testing:
Lab
Project
Number:
MOBAY/
1093:
BL161601.
Unpublished
study
prepared
by
Colorado
Analytical
Research
&
Dev.,
Corp.
380
p.

41976602
Williams,
B.;
Conrath,
B.
(
1991)
Triadimefon/
Triadimenol
Freezer
Storage
Stability
Study
in
Wheat
Gain,
Grapes,
and
Tomatoes:
Amended
Report:
Lab
Project
Number:
36987­
1:
BL142301:
100105.
Unpublished
study
prepared
by
Analytical
Bio­
Chemistry
Laboratories.
417
p.

42013201
Pither,
K.
(
1991)
Triadimefon
(
500DF):
Magnitude
of
the
Residue
on
Pineapple
Processed
Products:
Lab
Project
Number:
BL19PN02B:
101325.
Unpublished
study
prepared
by
ABC
Labs,
Inc.
and
Maui
Pineapple
Company,
Ltd.
324
p.

42123401
Krolski,
M.
(
1991)
Addendum
I:
Raw
Data
on
the
Fate
of
?
carbon
14|
Triadimefon
on
Tomatoes
and
Cucumbers:
Lab
Project
Number:
68593
­
1.
Unpublished
study
prepared
by
Stoner
Labs,
Inc.
20
p.

42123402
Minor,
R.
(
1991)
Addendum
I:
Raw
Data
for
the
Metabolism
of
Triadim
efon
in
Apples:
Lab
Project
Number:
53621­
1.
Unpublished
study
prepared
by
Mobay
Corp.
19
p.

42123403
Duah,
F.
(
1991)
Addendum
I:
Raw
Data
on
The
Metabolism
of
Bayleton
on
Grapes:
Lab
Project
Number:
88790­
1.
Unpublished
study
pre­
pared
by
Mobay
Corp.
27
p.

42123404
Chopade,
H.
(
1991)
Addendum
I:
Raw
Data
for
the
Metabolism
of
Triadimefon
in
Male
and
Female
Pigs:
Lab
Project
Number:
66509­
1.
51
p.

42613301
Mattern,
G.
C.,
Parker,
G.
D.,
and
Wendt,
S.
N.
(
1992)
Confined
Accumulation
of
[
phenyl­
UL­
14C]
Triadimefon
Residues
in
Rotational
Crops.
Laboratory
Study
Nos.:
Miles,
Inc.:
BL051601;
Plant
Sciences,
Inc.:
91.027;
PTRL
West,
Inc.:
P309W;
Miles
Report
No.
103806.
Unpublished
study
conducted
by
Plant
Sciences,
Inc.,
Watsonville,
CA
and
PTRL
West,
Inc.,
Richmond,
CA,
and
sponsored
by
Miles,
Inc.,
Kansas
City,
MO.
152
p.

42696308
Williams,
B.
(
1992)
Triadimenol­­
Magnitude
of
the
Residue
on
Barley,
2.6F
ST:
Amended
Final
Report:
Lab
Project
Number:
38700­
1:
BT19BA01:
100351.
Unpublished
study
prepared
by
ABC
Laboratory.
410
p.

42696309
Williams,
B.
(
1992)
Triadimenol­­
Magnitude
of
the
Residue
on
Oats,
2.6F
ST:
Amended
Final
Report:
Lab
Project
Number:
388151:
BT19OA01:
100352.
Unpublished
study
prepared
by
ABC
Laboratories,
Inc.
368
p.

42712101
Williams,
B.
(
1992)
Triadimenol­­
Magnitude
of
the
Residue
on
Wheat,
2.6F
ST.
Unpublished
study
prepared
by
ABC
Laboratories,
Inc.
432
p.

42798901
Krolski,
M.
(
1993)
Fate
of
Bayleton­(
carbon
14)
as
a
25
Percent
Wettable
Powder
on
Tomatoes
and
Triadimenol
Summary
Analytical
Chemistry
and
Residue
Data
­
TRED
DP
Barcode:
314891
39
of
44
Cucumbers.
Mass
Spectral
Data
on
(
carbon
14)
Triadimefon
Residues.

42853401
Chopade,
H.
(
1993)
Metabolism
of
(
Phenyl­
UL­(
carbon
14))
Triadimefon
in
Wheat:
Lab
Project
Number:
BL041601:
105162.
Unpublished
study
prepared
by
Miles
Inc.,
Agricultural
Div.
141
p.

42856801
Hall,
L.;
Hartz,
A.
(
1993)
The
Metabolism
of
(
carbon
14)
Triadimefon
in
the
Lactating
Goat:
Lab
Project
Number:
BL041001:
105161.
Unpublished
study
prepared
by
Miles
Inc.
160
p.

42857401
Williams,
B.;
Chickering,
C.
(
1993)
Triadimefon
and
Metabolites­­
Freezer
Storage
Stability
Study
in
Raw
Agricultural
Commodities
and
Processed
Products:
Lab
Project
Number:
396832:
BL131601:
102641­
1.
Unpublished
study
prepared
by
ABC
Labs,
Inc.
150
p.

42864901
Duah,
F.;
Smasal,
T.
(
1993)
Metabolism
of
Triadimefon
in
Laying
Hens:
Lab
Project
Number:
BL040501:
105183.
Unpublished
study
prepared
by
Miles
Inc.
129
p.

43418301
Hall,
L.;
Hartz,
A.
(
1994)
The
Metabolism
of
(
carbon
14)
Triadimefon
in
the
Lactating
Goat:
Addendum
1:
Additional
Data
as
Requested
by
the
EPA:
Lab
Project
Number:
BL041001:
105161­
1.
Unpublished
study
prepared
by
Miles,
Inc.
12
p.

43418302
Duah,
F.;
Myers,
T.
(
1994)
Metabolism
of
Triadimefon
in
Laying
Hens:
Addendum
1:
Additional
Data
as
Requested
by
EPA:
Lab
Project
Number:
BL040501:
105183­
1.
Unpublished
study
prepared
by
Miles,
Inc.
17
p.

43418303
Duah,
F.;
Myers,
T.;
Freeseman,
P.
(
1994)
Extraction
Efficiency
of
the
Analytical
Method
for
Triadimefon
Residues
in
Meat,
Milk,
and
Eggs:
Lab
Project
Numbers:
BL200201:
106449.
Unpublished
study
prepared
by
Miles,
Inc.
44
p.

43462401
Duah,
F.
(
1994)
Storage
Stability
of
Triadimefon
Residues
in
Animal
Tissues,
Milk,
and
Eggs:
Lab
Project
Number:
BL130201:
106638.
Unpublished
study
prepared
by
Miles
Inc.
37
p.

43705401
Fomenko,
J.
(
1995)
Evaluation
of
KWG
1732
(
a
Triadimefon
Metabolite)
Through
the
FDA
Multiresidue
Methods:
Lab
Project
Numbers:
K2162301:
106963:
A012.009.
Unpublished
study
prepared
by
Huntingdon
Analytical
Services.
97
p.

43870101
Bajzik,
M.
(
1995)
Independent
Laboratory
Validation
of
the
Analytical
Residue
Method
for
Triadimefon
and
Metabolites
in
Plant
Matrices
(
Report
No.
106549):
Lab
Project
Number:
A012.014:
BL111601:
107141.
Unpublished
study
prepared
by
Huntingdon
Analytical
Services.
121
p.

44029301
Grace,
T.
(
1996)
BAYLETON
50WP
­
Magnitude
of
the
Residue
in
Wheat
Processed
Products:
Lab
Project
Number:
BL19WH02:
107130:
PR95322.
Unpublished
study
prepared
by
Bayer
Corp.;
Texas
A&
M
University;
and
Maxim
Technologies,
Inc.
2508
p.

44038901
Lenz,
C.
(
1996)
Triadimefon
and
Metabolites­­
Freezer
Storage
Stability
Study
in
Raw
Agricultural
Commodities
and
Processed
Commodities:
Addendum
2:
Lab
Project
Number:
BL131601:
102641­
2:
39683.
Unpublished
study
prepared
by
ABC
Laboratories,
Inc.
586
p.

44041001
Chopade,
H.
(
1996)
Metabolism
of
(
Phenyl­
UL­(
carbon
14))
Triadimefon
in
Wheat:
Addendum
1­­
Storage
Stability
of
(
carbon14)
KWG
1732
in
Wheat
Grain:
Lab
Project
Number:
BL221601:
105162­
1.
Unpublished
study
prepared
by
Bayer
Corp.
30
p.

44041002
Chopade,
H.
(
1996)
Extraction
Efficiency
of
the
Analytical
Residue
Method
for
the
Determination
of
Triadimefon
and
Metabolite
Residues
in
Plant
Matrices:
Determination
of
Aged
(
carbon
14)
Triadimefon
Residues
in
Wheat
Grain:
Lab
Project
Number:
BL221601:
107343.
Unpublished
study
prepared
by
Bayer
Corp.
35
p.

44519801
Shen,
S.
(
1998)
Determination
of
Residues
of
Baytan
30
in
Processed
Field
Corn
Fractions:
Lab
Project
Number:
96­
003:
963HI:
43514.
Unpublished
study
prepared
by
ABC
Labs.,
Inc.
and
Gustafson
Research
and
Development
Center.
458
p.
{
OPPTS
860.1520}
Triadimenol
Summary
Analytical
Chemistry
and
Residue
Data
­
TRED
DP
Barcode:
314891
40
of
44
44519802
Shen,
S.
(
1998)
Determination
of
Residues
of
Baytan
30
in
Processed
Cotton
Fractions:
Lab
Project
Number:
96­
001:
963HG:
43516.
Unpublished
study
prepared
by
ABC
Labs.,
Inc.
and
Gustafson
Research
and
Development
Center.
452
p.
{
OPPTS
860.1520}

44519803
Shen,
S.
(
1998)
Determination
of
Residues
of
Baytan
30
in
Processed
Wheat
Fractions:
Lab
Project
Number:
96­
002:
963HH:
43513.
Unpublished
study
prepared
by
ABC
Labs.,
Inc.
and
Gustafson
Research
and
Development
Center.
462
p.
{
OPPTS
860.1520}

Appendix
1.
Food/
Food
Use
Patterns
for
Triadimenol.

This
document
was
originally
prepared
by
the
Biological
and
Economic
Analysis
Division
(
BEAD).
Current
as
of:
3/
2/
2005.

SITE
NAME
LIMITATIONS
Application
Timing
(
for
any
Reg.#
at
any
rate)

Application
Type
(
for
any
Reg.#
at
any
rate)

Application
Equipment
(
for
any
Reg.#
at
any
rate)
Max.
Single
Appl.

Rate
to
a
Single
Site
Max.
Seasonal
Rate
Max.
#

Apps/

cc
&
yr
M
R
I
R
E
I
PHI/
PGI/
PSI
Use
Limitations
(
May
not
apply
to
all
Reg.
#
s)

BARLEY
40
day(
s)
pregrazing
interval.

Do
not
apply
directly
to
water,
or
to
areas
where
surface
water
is
present
or
to
intertidal
areas
below
the
mean
high
water
mark.

Do
not
apply
through
any
type
of
irrigation
system.

Do
not
contaminate
food
or
feed.

Do
not
contaminate
water
by
cleaning
of
equipment
or
disposal
of
equipment
wash
waters.

Do
not
contaminate
water,
food
or
feed.

Do
not
contaminate
water,
food,
or
feed
by
storage
or
disposal.

Do
not
place
in
locations
accessible
to
children,
pets
or
domestic
animals.

Do
not
use
seed
for
food,
feed
or
oil
purposes.

For
terrestrial
uses,
do
not
apply
directly
to
water
or
to
areas
where
surface
water
is
present
or
to
intertidal
areas
below
the
mean
high
water
mark.

Keep
out
of
lakes,
streams,
and
ponds.

Seed
Seed
treatment
.03125
lb
cwt
NS
NS
NS
NS
12
h
Triadimenol
Summary
Analytical
Chemistry
and
Residue
Data
­
TRED
DP
Barcode:
314891
SITE
NAME
LIMITATIONS
Application
Timing
(
for
any
Reg.#
at
any
rate)

Application
Type
(
for
any
Reg.#
at
any
rate)

Application
Equipment
(
for
any
Reg.#
at
any
rate)
Max.
Single
Appl.

Rate
to
a
Single
Site
Max.
Seasonal
Rate
Max.
#

Apps/

cc
&
yr
M
R
I
R
E
I
PHI/
PGI/
PSI
Use
Limitations
(
May
not
apply
to
all
Reg.
#
s)

41
of
44
Mist­
type
seed
treater/
Slurry­
type
seed
treater
CORN
(
UNSPECIFIED)
45
day(
s)
pregrazing
interval.

Do
not
apply
directly
to
water,
or
to
areas
where
surface
water
is
present
or
to
intertidal
areas
below
the
mean
high
water
mark.

Do
not
apply
through
any
type
of
irrigation
system.

Do
not
contaminate
food
or
feed.

Do
not
contaminate
water
by
cleaning
of
equipment
or
disposal
of
equipment
wash
waters.

Do
not
contaminate
water,
food
or
feed.

Do
not
contaminate
water,
food,
or
feed
by
storage
or
disposal.

Do
not
place
in
locations
accessible
to
children,
pets
or
domestic
animals.

Do
not
use
seed
for
food,
feed
or
oil
purposes.

For
terrestrial
uses,
do
not
apply
directly
to
water
or
to
areas
where
surface
water
is
present
or
to
intertidal
areas
below
the
mean
high
water
mark.

Keep
out
of
lakes,
streams,
and
ponds.

Seed
Seed
treatment
Mist­
type
seed
treater/
Slurry­
type
seed
treater
.0625
lb
cwt
NS
NS
NS
NS
12
h
COTTON
(
UNSPECIFIED)
Do
not
apply
directly
to
water,
or
to
areas
where
surface
water
is
present
or
to
intertidal
areas
below
the
mean
high
water
mark.

Do
not
contaminate
food
or
feed.

Do
not
contaminate
water
by
cleaning
of
equipment
or
disposal
of
equipment
wash
waters.

Do
not
contaminate
water,
food,
or
feed
by
storage
or
disposal.

Do
not
enter
treated
areas
without
protective
clothing
until
sprays
have
dried.

Do
not
use
seed
for
food,
feed
or
oil
purposes.

Drift
and
runoff
may
be
hazardous
to
aquatic
organisms
in
neighboring
areas.

Groundwater
restriction.

This
pesticide
is
toxic
to
aquatic
invertebrates.

This
product
is
toxic
to
fish.

Geographic
disallowable:
Other
Seed
Seed
treatment
Mist­
type
seed
treater/
Slurry­
type
seed
treater
.06211
lb
cwt
NS
NS
NS
NS
24
h
OATS
40
day(
s)
pregrazing
interval.

Do
not
apply
directly
to
water,
or
to
areas
where
surface
water
is
present
or
to
Triadimenol
Summary
Analytical
Chemistry
and
Residue
Data
­
TRED
DP
Barcode:
314891
SITE
NAME
LIMITATIONS
Application
Timing
(
for
any
Reg.#
at
any
rate)

Application
Type
(
for
any
Reg.#
at
any
rate)

Application
Equipment
(
for
any
Reg.#
at
any
rate)
Max.
Single
Appl.

Rate
to
a
Single
Site
Max.
Seasonal
Rate
Max.
#

Apps/

cc
&
yr
M
R
I
R
E
I
PHI/
PGI/
PSI
Use
Limitations
(
May
not
apply
to
all
Reg.
#
s)

42
of
44
intertidal
areas
below
the
mean
high
water
mark.

Do
not
apply
through
any
type
of
irrigation
system.

Do
not
contaminate
food
or
feed.

Do
not
contaminate
water
by
cleaning
of
equipment
or
disposal
of
equipment
wash
waters.

Do
not
contaminate
water,
food
or
feed.

Do
not
contaminate
water,
food,
or
feed
by
storage
or
disposal.

Do
not
place
in
locations
accessible
to
children,
pets
or
domestic
animals.

Do
not
use
seed
for
food,
feed
or
oil
purposes.

For
terrestrial
uses,
do
not
apply
directly
to
water
or
to
areas
where
surface
water
is
present
or
to
intertidal
areas
below
the
mean
high
water
mark.

Keep
out
of
lakes,
streams,
and
ponds.

Seed
Seed
treatment
Slurry­
type
seed
treater
.03125
lb
cwt
NS
NS
NS
NS
12
h
RYE
40
day(
s)
pregrazing
interval.

Do
not
apply
directly
to
water,
or
to
areas
where
surface
water
is
present
or
to
intertidal
areas
below
the
mean
high
water
mark.

Do
not
apply
through
any
type
of
irrigation
system.

Do
not
contaminate
food
or
feed.

Do
not
contaminate
water
by
cleaning
of
equipment
or
disposal
of
equipment
wash
waters.

Do
not
contaminate
water,
food
or
feed.

Do
not
contaminate
water,
food,
or
feed
by
storage
or
disposal.

Do
not
place
in
locations
accessible
to
children,
pets
or
domestic
animals.

Do
not
use
seed
for
food,
feed
or
oil
purposes.

For
terrestrial
uses,
do
not
apply
directly
to
water
or
to
areas
where
surface
water
is
present
or
to
intertidal
areas
below
the
mean
high
water
mark.

Keep
out
of
lakes,
streams,
and
ponds.

Seed
Seed
treatment
Mist­
type
seed
treater/
Slurry­
type
seed
treater
.03125
lb
cwt
NS
NS
NS
NS
12
h
WHEAT
40
day(
s)
pregrazing
interval.

Do
not
apply
directly
to
water,
or
to
areas
where
surface
water
is
present
or
to
intertidal
areas
below
the
mean
high
water
mark.

Do
not
apply
through
any
type
of
irrigation
system.

Do
not
contaminate
food
or
feed.
Triadimenol
Summary
Analytical
Chemistry
and
Residue
Data
­
TRED
DP
Barcode:
314891
SITE
NAME
LIMITATIONS
Application
Timing
(
for
any
Reg.#
at
any
rate)

Application
Type
(
for
any
Reg.#
at
any
rate)

Application
Equipment
(
for
any
Reg.#
at
any
rate)
Max.
Single
Appl.

Rate
to
a
Single
Site
Max.
Seasonal
Rate
Max.
#

Apps/

cc
&
yr
M
R
I
R
E
I
PHI/
PGI/
PSI
Use
Limitations
(
May
not
apply
to
all
Reg.
#
s)

43
of
44
Do
not
contaminate
water
by
cleaning
of
equipment
or
disposal
of
equipment
wash
waters.

Do
not
contaminate
water,
food
or
feed.

Do
not
contaminate
water,
food,
or
feed
by
storage
or
disposal.

Do
not
place
in
locations
accessible
to
children,
pets
or
domestic
animals.

Do
not
use
seed
for
food,
feed
or
oil
purposes.

For
terrestrial
uses,
do
not
apply
directly
to
water
or
to
areas
where
surface
water
is
present
or
to
intertidal
areas
below
the
mean
high
water
mark.

Keep
out
of
lakes,
streams,
and
ponds.

Seed
Seed
treatment
Slurry­
type
seed
treater
.03125
lb
cwt
NS
NS
NS
NS
12
h
PRODUCT
NUMBERS
CONTAINED
IN
THIS
REPORT
000264­
00742,
000264­
00760,
002935­
00459,
007501­
00091,
007501­
00186
HOMEOWNER
PRODUCTS
CONTAINED
IN
THIS
REPORT
None
HEADER
ABBREVIATIONS
Site
Name
­
The
site
name
refers
to
the
entity
(
crop,
building,
surface
or
article)
where
a
pesticide
is
applied
and/
or
which
is
being
protected.

Limitations
­
Precautionary
statements
related
to
the
use
of
the
product(
s).

Application
Timing
­
The
timing
of
pesticide
application
and
is
the
primary
application
sort
(
not
aggregated).

Application
Type
­
The
type
of
pesticide
application
(
aggregated).

Application
Equipment
­
The
equipment
used
to
apply
pesticide
(
aggregated).

Max.
Single
Appl.
Rate
to
a
Single
Site
­
Maximum
Dose
for
a
single
application
to
a
single
site.
System
calculated.

Max
Seasonal
Rate
­
The
maximum
amount
of
pesticide
that
can
be
applied
to
a
site
in
one
growing
season
(/
cc)
and
during
the
span
of
one
year
(/
yr).

Max.
#
Apps/
cc
&
yr
­
Maximum
Number
of
Applications
per
crop
cycle
and
per
year.

M
R
I
­
Minimum
Retreatment
Interval
(
days)
(
at
any
rate).
The
minimum
interval
between
pesticide
application
(
days).

R
E
I
­
ReEntry
Interval
­
The
minimum
amount
of
time
that
must
elapse
before
workers
can
reenter
a
treated
area.

PHI/
PGI/
PSI
Use
Limitations
(
May
not
apply
to
all
Reg.#
s)
­
Preharvest/
Pregrazing/
Preslaughter
Interval
use
limitations
pertinent
to
the
application.

Current
As
Of:
­
The
label
data
for
the
listed
products
in
this
report
is
current
as
of
this
date.

ABBREVIATIONS
AN
­
As
needed
NA
­
Not
Applicable
NS
­
Not
Specified
(
on
label)

(
L)
­
The
dosage
information
provided
is
from
the
label
in
terms
of
product
(
e.
g.,
ounces,
gallons,
or
pounds
of
the
product)
because
there
was
insufficient
information
(
e.
g.,
missing
density,
area,
or
active
ingredient
percentages)
to
provide
converted
dosage
information.
This
report
provides
active
ingredient
Triadimenol
Summary
Analytical
Chemistry
and
Residue
Data
­
TRED
DP
Barcode:
314891
44
of
44
percentage
in
the
product
for
the
reported
chemical
for
all
unconverted
label
dosage
information
if
this
information
is
available.
This
active
ingredient
percentage
information
is
displayed
next
to
the
form
code
abbreviations
(
e.
g.,
80%
WP).

UC
­
Unconverted
due
to
lack
of
data
(
on
label).

APPLICATION
RATE
W
:
PPM
calculated
by
weight
V
:
PPM
calculated
by
volume
U
:
Unknown
whether
PPM
is
given
by
weight
or
by
volume
~
:
The
dosage
information
includes
a
contribution
from
one
or
more
(
TQ,
CL,
BR,
I)
active
ingredients.

cwt
:
Hundred
Weight
nnE­
xx
:
nn
times
(
10
power
­
xx),
for
instance,
"
1.234E­
04"
is
equivalent
to
".
0001234"
