Ethofumesate
Dietary
Exposure
Assessment
DP
Barcode:
D326518
PC
Code:
110601
Page:
1
of
10
UNITED
STATES
ENVIRONMENTAL
PROTECTION
AGENCY
WASHINGTON,
D.
C.
20460
OFFICE
OF
PREVENTION,
PESTICIDES
AND
TOXIC
SUBSTANCES
MEMORANDUM
DATE:
3/
28/
2006
SUBJECT:
Ethofumesate
Acute
and
Chronic
Dietary
Exposure
Assessments
for
the
Section
3
Registration
Action
on
Onion,
Bulb.

PC
Code:
110601
DP
Barcode:
D326518
REVIEWER:
N.
Negron,
Biologist
MUERB
(
7505C)
Registration
Division
(
7505C)

THROUGH:
S.
Stanton,
Chemist
C.
Swartz,
Chemist
Dietary
Exposure
Science
Advisory
Council
(
DESAC)
Health
Effects
Division
(
7509C)

and
W.
Cutchin,
Chemist
Technical
Review
Branch/
Registration
Division
Registration
Branch
(
7505C)

TO:
Shaja
Brothers
MUERB
Registration
Division
(
7505C)

Executive
Summary
An
acute
and
chronic
dietary
(
food+
water)
risk
assessment
was
conducted
using
the
Dietary
Exposure
Evaluation
Model
software
with
the
Food
Commodity
Intake
Database
(
DEEMFCID
 
,
Version
2.03),
which
uses
food
consumption
data
from
the
USDA's
Continuing
Surveys
of
Food
Intakes
by
Individuals
(
CSFII)
from
1994­
1996
and
1998.
The
analysis
was
performed
to
support
the
registration
request
to
add
the
uses
on
onion,
bulb.
The
acute
and
chronic
dietary
exposure/
risk
analyses
were
conducted
using
tolerance
values,
default
processing
factors,
and
100%
crop
treated
for
all
commodities.
The
maximum
concentration
for
acute
dietary
risk
assessment,
and
the
average
concentration
for
chronic
dietary
risk
assessment,
from
PRZM/
EXAMS
was
used
for
drinking
water
contribution
to
exposure.
Based
on
this
Tier
1
(
unrefined)
assessment,
the
team
selected
the
95th
percentile
of
exposure
to
estimate
acute
dietary
Ethofumesate
Dietary
Exposure
Assessment
DP
Barcode:
D326518
PC
Code:
110601
Page:
2
of
10
risk
from
food
and
water.
No
monitoring
data
are
available
for
ethofumesate.

Acute
Dietary
Exposure
Results
and
Characterization
A
conservative
acute
dietary
(
food
+
water)
assessment
was
performed
using
DEEMFCIDTM
Tolerance
level
residues
and
100%
crop
treated
were
used
in
the
assessment.
This
assessment
concludes
that
for
all
supported
commodities,
the
acute
dietary
exposure
estimate
is
below
HED's
level
of
concern
for
females
13­
49
years
of
age
(
the
only
population
subgroup
of
concern
identified
at
this
time)
at
4%
of
the
aPAD
at
the
95th
percentile.

Chronic
Dietary
Exposure
Results
and
Characterization
A
conservative
chronic
dietary
(
food
+
water)
assessment
was
performed
using
DEEMFCIDTM
Tolerance
level
residues
and
100%
crop
treated
were
used
in
the
assessment.
Dietary
risk
estimates
are
provided
for
the
general
U.
S.
population
and
various
population
subgroups.
This
assessment
concludes
that
for
all
supported
commodities,
the
chronic
dietary
exposure
estimates
are
below
HED's
level
of
concern
for
all
population
subgroups
at
1%
or
less
of
the
cPAD,
with
the
highest
exposure
to
all
infants
<
1
yr
old.

I.
Introduction
Dietary
risk
assessment
incorporates
both
exposure
and
toxicity
of
a
given
pesticide.
For
acute
and
chronic
assessments,
the
risk
is
expressed
as
a
percentage
of
a
maximum
acceptable
dose
(
i.
e.,
the
dose
which
HED
has
concluded
will
result
in
no
unreasonable
adverse
health
effects).
This
dose
is
referred
to
as
the
population­
adjusted
dose
(
PAD).
The
PAD
is
equivalent
to
the
reference
dose
(
RfD)
divided
by
the
special
Food
Quality
Protection
Act
(
FQPA)
Safety
Factor.

For
acute
and
non­
cancer
chronic
exposures,
HED
is
concerned
when
estimated
dietary
risk
exceeds
100%
of
the
PAD.
HED
is
generally
concerned
when
estimated
cancer
risk
exceeds
one
in
one
million
(
i.
e.,
the
risk
exceeds
1
x
10­
6).
References
which
discuss
the
acute
and
chronic
risk
assessments
in
more
detail
are
available
on
the
EPA/
pesticides
web
site:
"
Available
Information
on
Assessing
Exposure
from
Pesticides,
A
User's
Guide,"
6/
21/
2000,
web
link:
http://
www.
epa.
gov/
fedrgstr/
EPA­
PEST/
2000/
July/
Day­
12/
6061.
pdf;
or
see
SOP
99.6
(
8/
20/
99).

The
last
Dietary
Exposure
Assessment
for
ethofumesate,
"
Ethofumesate.
Revised
Acute
and
Chronic
Dietary
Exposure
Assessment
for
the
Reregistration
Eligibility
Decision"
was
completed
by
J.
Morales,
Chemist,
DP
Barcode:
DP296927,
on
July
6,
2005.

II.
Residue
Information
Ethofumesate
Use
Ethofumesate
Dietary
Exposure
Assessment
DP
Barcode:
D326518
PC
Code:
110601
Page:
3
of
10
Ethofumesate
tolerances
are
currently
established
for
the
combined
residues
of
ethofumesate
and
its
metabolites
NC
8493
and
NC
9607,
both
calculated
as
parent,
and
in/
on
plant
and
animal
commodities
in
40
CFR
§
180.345.
The
proposed
tolerance
for
onion,
bulb
is
0.25
ppm
which
also
automatically
includes
shallot
and
garlic.
The
carrot,
root
tolerance
used
in
the
analysis
was
7.0
ppm,
which
is
a
tolerance
to
be
proposed
under
40
CFR
180.345(
c)
to
support
a
regional
registration
restricted
to
WA
State.
The
current
tolerance
for
beet,
sugar,
root
at
0.1
ppm
is
scheduled
to
be
reassessed
at
0.5
ppm
(
DP
Num:
296927,
J.
Morales,
7/
6/
05).

Drinking
Water
Data
The
values
used
in
the
dietary
risk
assessment
were
provided
by
the
Environmental
Fate
and
Effects
Division
(
EFED)
in
the
following
memo:
Ethofumesate
 
Drinking
Water
Assessment
for
the
Health
Effects
Division
(
HED)
Reregistration
Eligibility
Decision
Document
(
DP
Num:
296949,
M.
Corbin,
6/
9/
04)
and
updated
by
e­
mail
from
Amer
Al­
Mudallal
to
José
Morales
on
7/
5/
05.
Water
residues
were
incorporated
in
the
DEEM­
FCID
 
into
the
food
categories
"
water,
direct,
all
sources"
and
"
water,
indirect,
all
sources".

Based
on
modeling
results,
the
maximum
estimated
surface
water­
derived
drinking
water
concentrations
for
the
use
of
ethofumesate
is
154
Fg/
L
(
used
for
the
acute
analysis)
using
the
Florida
turf
scenario.
The
maximum
1
in
10
year
annual
average
concentration
is
45.5
Fg/
l
(
used
for
the
chronic
analysis)
using
the
Florida
turf
scenario,
and
26
Fg/
L
for
the
30
year
annual
mean
concentration
for
the
Minnesota
sugar
beet
scenario.

III.
Program
and
Consumption
Information
Acute
and
chronic
dietary
exposure
assessments
were
conducted
for
ethofumesate
using
DEEMFCID
 
,
Version
2.03,
which
incorporates
consumption
data
from
USDA's
CSFII,
1994­
1996
and
1998.
The
1994­
96,
98
data
are
based
on
the
reported
consumption
of
more
than
20,000
individuals
over
two
non­
consecutive
survey
days.
Foods
"
as
consumed"
(
e.
g.,
apple
pie)
are
linked
to
EPA­
defined
food
commodities
(
e.
g.
apples,
peeled
fruit
­
cooked;
fresh
or
N/
S;
baked;
or
wheat
flour
­
cooked;
fresh
or
N/
S,
baked)
using
publicly
available
recipe
translation
files
developed
jointly
by
USDA/
ARS
and
EPA.
For
chronic
exposure
assessments,
consumption
data
are
averaged
for
the
entire
U.
S.
population
and
within
population
subgroups,
but
for
acute
exposure
assessment
are
retained
as
individual
consumption
events.
Based
on
analysis
of
the
1994­
96,
98
CSFII
consumption
data,
which
took
into
account
dietary
patterns
and
survey
respondents,
HED
concluded
that
it
is
most
appropriate
to
report
risk
for
the
following
population
subgroups:
the
general
U.
S.
population,
all
infants
(<
1
year
old),
children
1­
2,
children
3­
5,
children
6­
12,
youth
13­
19,
adults
20­
49,
females
13­
49,
and
adults
50+
years
old.

For
chronic
dietary
exposure
assessment,
an
estimate
of
the
residue
level
in
each
food
or
foodform
(
e.
g.,
orange
or
orange
juice)
on
the
food
commodity
residue
list
is
multiplied
by
the
average
daily
consumption
estimate
for
that
food/
food
form
to
produce
a
residue
intake
estimate.
The
resulting
residue
intake
estimate
for
each
food/
food
form
is
summed
with
the
residue
intake
estimates
for
all
other
food/
food
forms
on
the
commodity
residue
list
to
arrive
at
the
total
Ethofumesate
Dietary
Exposure
Assessment
DP
Barcode:
D326518
PC
Code:
110601
Page:
4
of
10
average
estimated
exposure.
Exposure
is
expressed
in
mg/
kg
body
weight/
day
and
as
a
percent
of
the
cPAD.
This
procedure
is
performed
for
each
population
subgroup.

IV.
Toxicological
Information
On
January
27,
2004,
the
Health
Effects
Division
(
HED)
Hazard
Identification
Assessment
Review
Committee
(
HIARC)
reviewed
the
recommendations
of
the
toxicology
reviewers
for
ethofumesate
with
regard
to
the
acute
and
chronic
Reference
Doses
(
RfDs)
and
the
toxicological
endpoint
selection
for
use
as
appropriate
in
occupational
and
residential
exposure
risk
assessments.
The
potential
for
increased
susceptibility
of
infants
and
children
from
exposure
to
ethofumesate
was
also
evaluated
as
required
by
the
Food
Quality
Protection
Act
(
FQPA)
of
1996
according
to
the
2002
Office
of
Pesticide
Programs
(
OPP)
10X
Guideline
Document.
Results
are
summarized
in
the
Table
below.

Table
1.
Summary
of
Toxicological
Dose
and
Endpoints
for
Ethofumesate
Exposure
Scenario
Dose
Used
in
Risk
Assessment,
UF
Special
FQPA
SF
and
Level
of
Concern
for
Risk
Assessment
Study
and
Toxicological
Effects
Acute
Dietary
(
Females
13­
49
years
of
age)
Developmental
NOAEL
=
30
mg/
kg/
day
UF
=
100
Acute
RfD
=
0.30
mg/
kg/
day
FQPA
SF
=
1X
aPAD
=
acute
RfD
FQPA
SF
=
0.30
mg/
kg/
day
Developmental
toxicity
study
in
rabbits
MRIDs
00156606,
40263701,
41652501
Developmental
LOAEL
=
300
mg/
kg/
day
based
on
increased
resorptions,
post­
implantation
loss
and
incomplete
ossification
of
the
vertebral
arches.

Acute
Dietary
(
General
population
including
infants
and
children)
No
appropriate
acute
endpoint
identified
Chronic
Dietary
(
Females
13­
49
years
of
age)
Developmental
NOAEL
=
30
mg/
kg/
day
UF
=
100
Chronic
RfD
=
0.30
mg/
kg/
day
FQPA
SF
=
1X
cPAD
=
chronic
RfD
FQPA
SF
=
0.30
mg/
kg/
day
Developmental
toxicity
study
in
rabbits
MRIDs
00156606,
40263701,
41652501
Developmental
LOAEL
=
300
mg/
kg/
day
based
on
increased
resorptions,
post­
implantation
loss
and
incomplete
ossification
of
the
vertebral
arches.

Chronic
Dietary
(
General
population
including
infants
and
children)
NOAEL=
127
mg/
kg/
day
UF
=
100
Chronic
RfD
=
1.3
mg/
kg/
day
FQPA
SF
=
1X
cPAD
=
chronic
RfD
FQPA
SF
=
1.3
mg/
kg/
day
Chronic
oral
toxicity/
carcinogenicity
study
in
rat
MRIDs
44093603,
44093604
LOAEL
=
469
mg/
kg/
day
based
on
decreased
body
weight
gain
in
females.
Ethofumesate
Dietary
Exposure
Assessment
DP
Barcode:
D326518
PC
Code:
110601
Page:
5
of
10
Cancer
(
oral,
dermal,
inhalation)
Classification:
"
Not
likely
to
be
carcinogenic
to
humans"

UF
=
uncertainty
factor,
FQPA
SF
=
Special
FQPA
safety
factor,
NOAEL
=
no
observed
adverse
effect
level,
LOAEL
=
lowest
observed
adverse
effect
level,
PAD
=
population
adjusted
dose
(
a
=
acute,
c
=
chronic)
RfD
=
reference
dose
V.
Results/
Discussion
As
stated
above,
for
an
acute
assessment,
HED
is
concerned
when
dietary
risk
exceeds
100%
of
the
PAD.
The
DEEM­
FCID
 
analysis
estimates
the
dietary
exposure
of
the
U.
S.
population
and
various
population
subgroups.
The
acute
dietary
(
food
+
water)
exposure
analysis
results
are
reported
in
Table
2
for
females
13­
49
years
of
age
which
is
the
only
population
subgroup
of
concern
toxicologically
identified
at
this
time.
The
resulting
food
exposure
estimates
are
below
HED's
level
of
concern
for
this
population
subgroup,
4%
of
the
aPAD
at
the
95th
percentile.

The
chronic
dietary
exposure
analysis
results
reported
in
Table
3
for
the
general
U.
S.
population,
all
infants
(<
1
year
old),
children
1­
2,
children
3­
5,
children
6­
12,
youth
13­
19,
females
13­
49,
adults
20­
49,
and
adults
50+
years.
The
resulting
food
exposure
estimates
are
below
HED's
level
of
concern
for
all
population
subgroups.
The
highest
exposed
population
subgroup
was
all
infants
<
1
yr
old
at
<
1%
of
the
cPAD.

Table
2:
Summary
of
Acute
Dietary
(
food
+
water)
Exposure
and
Risk
for
Ethofumesate.

Population
Subgroup
aPAD
(
mg/
kg/
day)
Exposure
(
mg/
kg/
day)
%
aPAD
95th
Percentile
Exposure
(
mg/
kg/
day)
%
aPAD
99th
Percentile
Exposure
(
mg/
kg/
day)
%
aPAD
99.9th
Percentile
Females
13­
49
years
old
0.3
0.011837
4
0.020548
7
0.041708
14
Table
3:
Summary
of
Chronic
Dietary
(
food+
water)
Exposure
and
Risk
for
Ethofumesate.

Exposure
(
mg/
kg/
day)
%
cPAD
Population
Subgroup
cPAD
(
mg/
kg/
day)

General
U.
S.
Population
0.002604
<
1
All
Infants
(<
1
year
old)
0.011013
<
1
Children
1­
2
years
old
0.006256
<
1
Children
3­
5
years
old
0.004442
<
1
Children
6­
12
years
old
0.002944
<
1
Youth
13­
19
years
old
0.001756
<
1
Adults
20­
49
years
old
0.002142
<
1
Adults
50+
years
old
1.3
0.002341
<
1
Females
13­
49
years
old
0.3
0.002179
<
1
Ethofumesate
Dietary
Exposure
Assessment
DP
Barcode:
D326518
PC
Code:
110601
Page:
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VI.
Conclusions
An
acute
and
chronic
dietary
(
food+
water)
risk
assessment
was
conducted
using
the
Dietary
Exposure
Evaluation
Model
software
with
the
Food
Commodity
Intake
Database
(
DEEM­
FCID
 
,
Version
2.03),
which
uses
food
consumption
data
from
the
USDA's
Continuing
Surveys
of
Food
Intakes
by
Individuals
(
CSFII)
from
1994­
1996
and
1998.
The
acute
and
chronic
dietary
exposure/
risk
analyses
were
conducted
using
tolerance
values,
default
processing
factors,
processing
factor
from
sugar
beet
processing
studies,
and
100%
crop
treated
for
all
commodities.
The
maximum
concentration
for
acute
dietary
risk
assessment,
and
the
average
concentration
for
chronic
dietary
risk
assessment,
from
PRZM/
EXAMS
was
used
for
drinking
water
contribution
to
exposure.
Based
on
this
Tier
1
(
unrefined)
assessment,
the
team
selected
the
95th
percentile
of
exposure
to
estimate
acute
dietary
risk
from
food
and
water.
No
monitoring
data
are
available
for
ethofumesate.

This
assessment
concludes
that
for
all
supported
commodities,
the
acute
dietary
exposure
estimates
are
below
HED's
level
of
concern
for
females
13­
49
years
of
age
at
4
%
of
the
aPAD
at
the
95th
percentile.

This
assessment
concludes
that
for
all
supported
commodities,
the
chronic
dietary
exposure
estimates
are
below
HED's
level
of
concern
for
all
population
subgroups
at
<
1%
of
the
cPAD.

VII.
List
of
Attachments
°
Attachment
1:
Chronic
Residue
Input
file.
°
Attachment
2:
Chronic
Results
file.
°
Attachment
3:
Acute
Residue
Input
file.
°
Attachment
4:
Acute
Results
file.
Ethofumesate
Dietary
Exposure
Assessment
DP
Barcode:
D326518
PC
Code:
110601
Page:
7
of
10
Attachment
1:
Chronic
Residue
File
Filename:
I:\
working\
Ethofumesate\
110601c.
R98
Chemical:
Ethofumesate
RfD(
Chronic):
1.3
mg/
kg
bw/
day
NOEL(
Chronic):
0
mg/
kg
bw/
day
RfD(
Acute):
.3
mg/
kg
bw/
day
NOEL(
Acute):
0
mg/
kg
bw/
day
Date
created/
last
modified:
03­
24­
2006/
13:
19:
47/
8
Program
ver.
2.03
Comment:
Females
13+
=
0.3
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
EPA
Crop
Def
Res
Adj.
Factors
Comment
Code
Grp
Commodity
Name
(
ppm)
#
1
#
2
­­­­­­­­
­­­­
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­
­­­­­­
­­­­­­
­­­­­­­
21000440
M
Beef,
meat
0.050000
1.000
1.000
21000441
M
Beef,
meat­
babyfood
0.050000
1.000
1.000
21000450
M
Beef,
meat,
dried
0.050000
1.920
1.000
21000460
M
Beef,
meat
byproducts
0.050000
1.000
1.000
21000461
M
Beef,
meat
byproducts­
babyfood
0.050000
1.000
1.000
21000470
M
Beef,
fat
0.050000
1.000
1.000
21000471
M
Beef,
fat­
babyfood
0.050000
1.000
1.000
21000480
M
Beef,
kidney
0.050000
1.000
1.000
21000490
M
Beef,
liver
0.050000
1.000
1.000
21000491
M
Beef,
liver­
babyfood
0.050000
1.000
1.000
01010500
1AB
Beet,
garden,
roots
0.500000
1.000
1.000
01010501
1AB
Beet,
garden,
roots­
babyfood
0.500000
1.000
1.000
02000510
2
Beet,
garden,
tops
5.000000
1.000
1.000
01010520
1A
Beet,
sugar
0.500000
1.000
1.000
01010521
1A
Beet,
sugar­
babyfood
0.500000
1.000
1.000
01010530
1A
Beet,
sugar,
molasses
0.500000
1.000
1.000
01010531
1A
Beet,
sugar,
molasses­
babyfood
0.500000
1.000
1.000
01010780
1AB
Carrot
7.000000
1.000
1.000
01010781
1AB
Carrot­
babyfood
7.000000
1.000
1.000
01010790
1AB
Carrot,
juice
7.000000
1.000
1.000
03001640
3
Garlic
0.250000
1.000
1.000
03001650
3
Garlic,
dried
0.250000
1.000
1.000
03001651
3
Garlic,
dried­
babyfood
0.250000
1.000
1.000
23001690
M
Goat,
meat
0.050000
1.000
1.000
23001700
M
Goat,
meat
byproducts
0.050000
1.000
1.000
23001710
M
Goat,
fat
0.050000
1.000
1.000
23001720
M
Goat,
kidney
0.050000
1.000
1.000
23001730
M
Goat,
liver
0.050000
1.000
1.000
24001890
M
Horse,
meat
0.050000
1.000
1.000
03002370
3
Onion,
dry
bulb
0.250000
1.000
1.000
03002371
3
Onion,
dry
bulb­
babyfood
0.250000
1.000
1.000
03002380
3
Onion,
dry
bulb,
dried
0.250000
1.000
1.000
03002381
3
Onion,
dry
bulb,
dried­
babyfood
0.250000
1.000
1.000
25002900
M
Pork,
meat
0.050000
1.000
1.000
25002901
M
Pork,
meat­
babyfood
0.050000
1.000
1.000
25002910
M
Pork,
skin
0.050000
1.000
1.000
25002920
M
Pork,
meat
byproducts
0.050000
1.000
1.000
25002921
M
Pork,
meat
byproducts­
babyfood
0.050000
1.000
1.000
25002930
M
Pork,
fat
0.050000
1.000
1.000
25002931
M
Pork,
fat­
babyfood
0.050000
1.000
1.000
25002940
M
Pork,
kidney
0.050000
1.000
1.000
25002950
M
Pork,
liver
0.050000
1.000
1.000
03003380
3
Shallot
0.250000
1.000
1.000
26003390
M
Sheep,
meat
0.050000
1.000
1.000
26003391
M
Sheep,
meat­
babyfood
0.050000
1.000
1.000
26003400
M
Sheep,
meat
byproducts
0.050000
1.000
1.000
26003410
M
Sheep,
fat
0.050000
1.000
1.000
26003411
M
Sheep,
fat­
babyfood
0.050000
1.000
1.000
26003420
M
Sheep,
kidney
0.050000
1.000
1.000
26003430
M
Sheep,
liver
0.050000
1.000
1.000
86010000
O
Water,
direct,
all
sources
0.045500
1.000
1.000
86020000
O
Water,
indirect,
all
sources
0.045500
1.000
1.000
Ethofumesate
Dietary
Exposure
Assessment
DP
Barcode:
D326518
PC
Code:
110601
Page:
8
of
10
Attachment
2:
Chronic
Results
File
U.
S.
Environmental
Protection
Agency
Ver.
2.00
DEEM­
FCID
Chronic
analysis
for
ETHOFUMESATE
(
1994­
98
data)
Residue
file
name:
I:\
working\
Ethofumesate\
110601c.
R98
Adjustment
factor
#
2
NOT
used.
Analysis
Date
03­
24­
2006/
13:
21:
41
Residue
file
dated:
03­
24­
2006/
13:
19:
47/
8
Reference
dose
(
RfD,
Chronic)
=
1.3
mg/
kg
bw/
day
COMMENT
1:
Females
13+
=
0.3
===============================================================================
Total
exposure
by
population
subgroup
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­

Total
Exposure
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Population
mg/
kg
Percent
of
Subgroup
body
wt/
day
PAD
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­­­­
­­­­­­­­­­­­­­­
U.
S.
Population
(
total)
0.002604
0.2%

U.
S.
Population
(
spring
season)
0.002560
0.2%
U.
S.
Population
(
summer
season)
0.002456
0.2%
U.
S.
Population
(
autumn
season)
0.002669
0.2%
U.
S.
Population
(
winter
season)
0.002734
0.2%

Northeast
region
0.002592
0.2%
Midwest
region
0.002629
0.2%
Southern
region
0.002325
0.2%
Western
region
0.003029
0.2%

Hispanics
0.002864
0.2%
Non­
hispanic
whites
0.002604
0.2%
Non­
hispanic
blacks
0.002081
0.2%
Non­
hisp/
non­
white/
non­
black
0.003470
0.3%

All
infants
(<
1
year)
0.011013
0.8%
Nursing
infants
0.006121
0.5%
Non­
nursing
infants
0.012870
1.0%
Children
1­
6
yrs
0.004983
0.4%
Children
7­
12
yrs
0.002743
0.2%

Females
13­
19
(
not
preg
or
nursing)
(.
3*)
0.001716
0.6%
Females
20+
(
not
preg
or
nursing)
(.
3*)
0.002325
0.8%
Females
13­
50
yrs
(.
3*)
0.002328
0.8%
Females
13+
(
preg/
not
nursing)
(.
3*)
0.002423
0.8%
Females
13+
(
nursing)
(.
3*)
0.003601
1.2%

Males
13­
19
yrs
0.001781
0.1%
Males
20+
yrs
0.002076
0.2%
Seniors
55+
0.002378
0.2%

Children
1­
2
yrs
0.006256
0.5%
Children
3­
5
yrs
0.004442
0.3%
Children
6­
12
yrs
0.002944
0.2%
Youth
13­
19
yrs
0.001756
0.1%
Adults
20­
49
yrs
0.002142
0.2%
Adults
50+
yrs
0.002341
0.2%
Females
13­
49
yrs
(.
3*)
0.002179
0.7%

*
PAD
in
mg/
kg­
bw­
day
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Ethofumesate
Dietary
Exposure
Assessment
DP
Barcode:
D326518
PC
Code:
110601
Page:
9
of
10
Attachment
3:
Acute
Residue
File
Filename:
I:\
working\
Ethofumesate\
110601a.
R98
Chemical:
Ethofumesate
RfD(
Chronic):
1.3
mg/
kg
bw/
day
NOEL(
Chronic):
0
mg/
kg
bw/
day
RfD(
Acute):
.3
mg/
kg
bw/
day
NOEL(
Acute):
0
mg/
kg
bw/
day
Date
created/
last
modified:
03­
24­
2006/
13:
18:
47/
8
Program
ver.
2.03
Comment:
Chronic
PAD
for
Females
=
0.3
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
EPA
Crop
Def
Res
Adj.
Factors
Comment
Code
Grp
Commodity
Name
(
ppm)
#
1
#
2
­­­­­­­­
­­­­
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­
­­­­­­
­­­­­­
­­­­­­­
21000440
M
Beef,
meat
0.050000
1.000
1.000
21000441
M
Beef,
meat­
babyfood
0.050000
1.000
1.000
21000450
M
Beef,
meat,
dried
0.050000
1.920
1.000
21000460
M
Beef,
meat
byproducts
0.050000
1.000
1.000
21000461
M
Beef,
meat
byproducts­
babyfood
0.050000
1.000
1.000
21000470
M
Beef,
fat
0.050000
1.000
1.000
21000471
M
Beef,
fat­
babyfood
0.050000
1.000
1.000
21000480
M
Beef,
kidney
0.050000
1.000
1.000
21000490
M
Beef,
liver
0.050000
1.000
1.000
21000491
M
Beef,
liver­
babyfood
0.050000
1.000
1.000
01010500
1AB
Beet,
garden,
roots
0.500000
1.000
1.000
01010501
1AB
Beet,
garden,
roots­
babyfood
0.500000
1.000
1.000
02000510
2
Beet,
garden,
tops
5.000000
1.000
1.000
01010520
1A
Beet,
sugar
0.500000
1.000
1.000
01010521
1A
Beet,
sugar­
babyfood
0.500000
1.000
1.000
01010530
1A
Beet,
sugar,
molasses
0.500000
1.000
1.000
01010531
1A
Beet,
sugar,
molasses­
babyfood
0.500000
1.000
1.000
01010780
1AB
Carrot
7.000000
1.000
1.000
01010781
1AB
Carrot­
babyfood
7.000000
1.000
1.000
01010790
1AB
Carrot,
juice
7.000000
1.000
1.000
03001640
3
Garlic
0.250000
1.000
1.000
03001650
3
Garlic,
dried
0.250000
1.000
1.000
03001651
3
Garlic,
dried­
babyfood
0.250000
1.000
1.000
23001690
M
Goat,
meat
0.050000
1.000
1.000
23001700
M
Goat,
meat
byproducts
0.050000
1.000
1.000
23001710
M
Goat,
fat
0.050000
1.000
1.000
23001720
M
Goat,
kidney
0.050000
1.000
1.000
23001730
M
Goat,
liver
0.050000
1.000
1.000
24001890
M
Horse,
meat
0.050000
1.000
1.000
03002370
3
Onion,
dry
bulb
0.250000
1.000
1.000
03002371
3
Onion,
dry
bulb­
babyfood
0.250000
1.000
1.000
03002380
3
Onion,
dry
bulb,
dried
0.250000
1.000
1.000
03002381
3
Onion,
dry
bulb,
dried­
babyfood
0.250000
1.000
1.000
25002900
M
Pork,
meat
0.050000
1.000
1.000
25002901
M
Pork,
meat­
babyfood
0.050000
1.000
1.000
25002910
M
Pork,
skin
0.050000
1.000
1.000
25002920
M
Pork,
meat
byproducts
0.050000
1.000
1.000
25002921
M
Pork,
meat
byproducts­
babyfood
0.050000
1.000
1.000
25002930
M
Pork,
fat
0.050000
1.000
1.000
25002931
M
Pork,
fat­
babyfood
0.050000
1.000
1.000
25002940
M
Pork,
kidney
0.050000
1.000
1.000
25002950
M
Pork,
liver
0.050000
1.000
1.000
03003380
3
Shallot
0.250000
1.000
1.000
26003390
M
Sheep,
meat
0.050000
1.000
1.000
26003391
M
Sheep,
meat­
babyfood
0.050000
1.000
1.000
26003400
M
Sheep,
meat
byproducts
0.050000
1.000
1.000
26003410
M
Sheep,
fat
0.050000
1.000
1.000
26003411
M
Sheep,
fat­
babyfood
0.050000
1.000
1.000
26003420
M
Sheep,
kidney
0.050000
1.000
1.000
26003430
M
Sheep,
liver
0.050000
1.000
1.000
86010000
O
Water,
direct,
all
sources
0.154000
1.000
1.000
86020000
O
Water,
indirect,
all
sources
0.154000
1.000
1.000
Ethofumesate
Dietary
Exposure
Assessment
DP
Barcode:
D326518
PC
Code:
110601
Page:
10
of
10
Attachment
4:
Acute
Results
File
U.
S.
Environmental
Protection
Agency
Ver.
2.02
DEEM­
FCID
ACUTE
Analysis
for
ETHOFUMESATE
(
1994­
98
data)
Residue
file:
110601a.
R98
Adjustment
factor
#
2
NOT
used.
Analysis
Date:
03­
24­
2006/
13:
22:
43
Residue
file
dated:
03­
24­
2006/
13:
18:
47/
8
Daily
totals
for
food
and
foodform
consumption
used.
Run
Comment:
"
Chronic
PAD
for
Females
=
0.3"
===============================================================================

Summary
calculations
(
per
capita):

95th
Percentile
99th
Percentile
99.9th
Percentile
Exposure
%
aRfD
Exposure
%
aRfD
Exposure
%
aRfD
­­­­­­­­­­
­­­­­­­­
­­­­­­­­­­
­­­­­­­­
­­­­­­­­­­
­­­­­­­­
Females
13­
49
yrs:
0.011837
3.95
0.020548
6.85
0.041708
13.90
