Page
1
of
13
UNITED
STATES
ENVIRONMENTAL
PROTECTION
AGENCY
WASHINGTON,
D.
C.
20460
OFFICE
OF
PREVENTION,
PESTICIDES
AND
TOXIC
SUBSTANCES
MEMORANDUM
Date:
10/
21/
05
Subject:
Imazaquin.
Tolerance
Reassessment
Eligibility
Decision
(
TRED).
Product
Chemistry
Considerations.

DP
Barcode:
D302940
PC
Code:
128848,
128840,
129023
From:
Danette
Drew,
Chemist
Reregistration
Branch
3
Health
Effects
Division
(
7509C)

Through:
Catherine
Eiden,
Branch
Chief
Reregistration
Branch
3
Health
Effects
Division
(
7509C)

To:
Susan
Stanton,
Risk
Assessor
Reregistration
Branch
3
Health
Effects
Division
(
7509C)

and
Craig
Doty,
CRM
Special
Review
Branch
Special
Review
and
Reregistration
Branch
(
7508C)

This
document
was
originally
prepared
under
contract
by
Dynamac
Corporation
(
20440
Century
Boulevard,
Suite
100;
Germantown,
MD
20874;
submitted
10/
03/
2005).
The
document
has
been
reviewed
by
the
HED
and
revised
to
reflect
current
OPP
policies.
Imazaquin
TRED:
Product
Chemistry
Considerations
Barcode:
D302940
Page
2
of
13
Executive
Summary
Imazaquin
is
an
imidazolinone­
type
herbicide
used
for
the
control
of
broadleaf
weeds
in
soybeans.
Imazaquin
also
has
registered
products
formulated
as
the
ammonium
salt
(
PC
code
128840)
and
sodium
salt
(
PC
Code
129023).
Data
were
initially
submitted
for
imazaquin
in
conjunction
with
petitions
for
imazaquin
on
soybeans
(
PP#
4G2979;
Memo
dated
3/
28/
84,
R.
Loranger,
and
PP#
5F3237;
Memo
dated
1/
9/
86,
A.
Smith).
No
product
chemistry
data
have
been
submitted
for
the
technical
grade
active
ingredients
(
TGAIs)
of
the
ammonium
and
sodium
salts
of
imazaquin.

Additional
product
chemistry
data
are
required
for
the
only
registered
manufacturing­
use
product
of
imazaquin,
the
BASF
95%
T
(
EPA
Reg.
No.
241­
287),
concerning
product
identity,
certified
limits,
stability,
storage
stability,
and
UV/
visible
absorption
(
OPPTS
830.1550,
1750,
6313,
6317,
and
7050).
All
generic
(
TGAI)
product
chemistry
data
are
required
for
the
BASF
ammonium
salt
TGAI,
the
Ambrands
ammonium
salt
TGAI,
and
the
BASF
sodium
salt
TGAI
(
OPPTS
830.1600,
1620,
1670,
1700,
6302,
6303,
6304,
6313,
7000,
7050,
7200,
7220,
7370,
7550,
7840,
xxxx
(
solvent
solubility),
and
7950).
Provided
that
the
registrants
submit
the
data
required
in
the
attached
data
summary
tables
for
the
imazaquin
T/
TGAI
and
the
imazaquin
salt
TGAIs,
and
either
certify
that
the
suppliers
of
beginning
materials
and
the
manufacturing
processes
for
the
imazaquin
and
imazaquin
salt
TGAIs
have
not
changed
or
submit
complete
updated
product
chemistry
data
packages,
the
Agency
has
no
objections
to
renewing
the
registration
of
imazaquin
and
its
ammonium
and
sodium
salts
as
required
under
FQPA
with
respect
to
product
chemistry
data
requirements.

Product
Chemistry
Deficiencies
Additional
data
are
required
concerning
product
identity,
certified
limits,
stability,
storage
stability,
and
UV/
visible
absorption
(
OPPTS
830.1550,
1750,
6313,
6317,
and
7050)
for
the
BASF
Corporation
imazaquin
95%
T
(
EPA
Reg.
No.
241­
287).

Additional
data
are
required
concerning
all
generic
product
chemistry
guidelines
(
OPPTS
830.1600,
1620,
1670,
1700,
6302,
6303,
6304,
6313,
7000,
7050,
7200,
7220,
7370,
7550,
7840,
xxxx
(
solvent
solubility),
and
7950)
for
the
BASF
Corporation
imazaquin
ammonium
salt
TGAI
and
Ambrands
imazaquin
ammonium
salt
TGAI.

Additional
data
are
required
concerning
all
generic
product
chemistry
guidelines
(
OPPTS
830.1600,
1620,
1670,
1700,
6302,
6303,
6304,
6313,
7000,
7050,
7200,
7220,
7370,
7550,
7840,
xxxx
(
solvent
solubility),
and
7950)
for
the
BASF
Corporation
imazaquin
sodium
salt
TGAI.

Background
and
Identification
of
Active
Ingredient
The
PC
code
and
nomenclature
of
imazaquin
and
its
ammonium
and
sodium
salts
are
listed
below
in
Table
1.
The
physicochemical
properties
of
imazaquin
are
listed
in
Table
2;
data
pertaining
to
the
physicochemical
properties
of
the
salts
are
not
available.
Imazaquin
TRED:
Product
Chemistry
Considerations
Barcode:
D302940
Page
3
of
13
N
N
H
N
OH
O
O
CH
3
CH(
CH
3
)
2
N
N
H
N
O
O
O
CH
3
CH(
CH
3
)
2
NH
4
+

N
N
H
N
O
O
O
CH
3
CH(
CH
3
)
2
Na
+
TABLE
1.
Imazaquin
and
Salts
Nomenclature
Chemical
structure
Common
name
Imazaquin
Molecular
Formula
C17H17N3O3
Molecular
Weight
311.34
IUPAC
name
(
RS)­
2­(
4­
isopropyl­
4­
methyl­
5­
oxo­
2­
imidazolin­
2­
yl)
quinoline­
3­
carboxylic
acid
CAS
name
2­[
4,5­
dihydro­
4­
methyl­
4­(
1­
methylethyl)­
5­
oxo­
1H­
imidazol­
2­
yl]­
3­
quinolinecarboxylic
acid
CAS
#
81335­
37­
7
PC
Code
128848
Chemical
structure
Common
name
Imazaquin,
ammonium
salt
IUPAC
name
(
RS)­
2­(
4­
isopropyl­
4­
methyl­
5­
oxo­
2­
imidazolin­
2­
yl)
quinoline­
3­
carboxylic
acid,
monoammonium
salt
CAS
name
2­[
4,5­
dihydro­
4­
methyl­
4­(
1­
methylethyl)­
5­
oxo­
1H­
imidazol­
2­
yl]­
3­
quinolinecarboxylic
acid,
monoammonium
salt
CAS
#
81335­
47­
9
PC
Code
128840
Chemical
structure
Common
name
Imazaquin,
sodium
salt
IUPAC
name
(
RS)­
2­(
4­
isopropyl­
4­
methyl­
5­
oxo­
2­
imidazolin­
2­
yl)
quinoline­
3­
carboxylic
acid,
monosodium
salt
CAS
name
2­[
4,5­
dihydro­
4­
methyl­
4­(
1­
methylethyl)­
5­
oxo­
1H­
imidazol­
2­
yl]­
3­
quinolinecarboxylic
acid,
monosodium
salt
Imazaquin
TRED:
Product
Chemistry
Considerations
Barcode:
D302940
TABLE
1.
Imazaquin
and
Salts
Nomenclature
Page
4
of
13
CAS
#
81335­
46­
8
PC
Code
129023
TABLE
2.
Physicochemical
Properties
of
Imazaquin
Parameter
Value
Reference
Melting
point
219­
224
°
C
(
decomposes)
MRID
00146197;
PP#
5F3273,
RCB
#
1265,
1/
9/
86,
A.
Smith
pH
4.6
at
25
°
C
Density,
bulk
density,
or
specific
gravity
0.39
g/
mL
untapped;
0.43
g/
mL
tapped
Water
solubility
at
25
°
C
60
ppm
Solvent
solubility
g/
100
mL
Acetone
0.30
DMF
6.80
DMSO
15.9
Ethanol
0.30
Heptane
0.02
Methanol
0.50
Methylene
chloride
1.36
Toluene
0.04
Vapor
pressure
<
2
x
10­
8
mm
Hg
at
45
°
C
Dissociation
constant,
pKa
3.8
Octanol/
water
partition
coefficient
2.2
at
22
°
C
UV/
visible
absorption
spectrum
Not
available
Data
remain
outstanding
Manufacturing­
use
Products
A
search
of
the
OPPIN
product
listings
conducted
08/
05
identified
a
single
manufacturing­
use
product
(
MP)
registered
under
PC
Code
128848
(
imazaquin):
the
BASF
Corporation
95%
T
(
EPA
Reg.
No.
241­
287).
No
registered
MPs
were
identified
under
PC
Code
128840
(
ammonium
salt)
or
129023
(
sodium
salt);
however
eight
imazaquin
ammonium
salt
end­
use
products
(
EPs)
and
a
single
imazaquin
sodium
salt
EP
are
currently
registered.
Based
on
examination
of
the
available
CSFs,
all
of
the
salt
EPs
are
manufactured
by
an
integrated
system
from
unregistered
TGAIs
and
are
listed
below
in
Table
3.
The
imazaquin
T/
TGAI
and
the
salt
TGAIs
are
subject
to
a
reregistration
eligibility
decision.

TABLE
3.
Imazaquin
Salt
End­
Use
Products
Manufactured
by
an
Integrated
System
from
an
Unregistered
TGAI.

Product
EPA
Reg.
No.
Registrant
Comments
Imazaquin
Ammonium
Salt
(
PC
Code
128840)

17.3%
EP
241­
289
BASF
Corporation
(
previously
American
Cyanamid)
17.3%
EP
241­
292
17.3%
EP
241­
303
4.72%
EP
241­
307
MAI
with
trifluralin
(
28.6%).
Imazaquin
TRED:
Product
Chemistry
Considerations
Barcode:
D302940
TABLE
3.
Imazaquin
Salt
End­
Use
Products
Manufactured
by
an
Integrated
System
from
an
Unregistered
TGAI.

Product
EPA
Reg.
No.
Registrant
Comments
Page
5
of
13
3.65%
EP
241­
327
MAI
with
pendimethalin
(
21.96%)

0.79%
EP
241­
326
0.75%
EP
241­
352
3.3%
EP
73342­
4
Ambrands
Transferred
6/
9/
2000
from
BASF
(
EPA
Reg.
No.
241­
351).

Imazaquin
Sodium
Salt
(
PC
Code
129023)

5.61%
EP
241­
321
BASF
Corporation
MAI
with
acifluorfen,
sodium
salt
(
20.93%)

830.1550­
7950
Product
Chemistry
Data
Requirements
The
current
status
of
the
product
chemistry
data
requirements
for
the
imazaquin
T/
TGAI
and
imazaquin
ammonium
and
sodium
salt
TGAIs
are
presented
in
the
attached
data
summary
tables.
Refer
to
these
tables
for
a
listing
of
the
outstanding
product
chemistry
data
requirements.
Imazaquin
TRED:
Product
Chemistry
Considerations
Barcode:
D302940
Page
6
of
13
Case
No.
None
Chemical
No.
128842
Case
Name:
Imazaquin
Registrant:
BASF
Corporation
Product(
s):
95%
T
(
EPA
Reg.
No.
241­
287)

PRODUCT
CHEMISTRY
DATA
SUMMARY
Guideline
Number
Requirement
Are
Data
Requirements
Fulfilled?
1
MRID
Number
2
830.1550
Product
identity
and
composition
N
3
00131546,
00146197
4,
CSF
8/
13/
86
830.1600
Description
of
materials
used
to
produce
the
product
Y
00131546,
00146197
4
830.1620
Description
of
production
process
Y
00131546,
00146197
4
830.1670
Discussion
of
formation
of
impurities
Y
00146197
4
830.1700
Preliminary
analysis
Y
00146197
4
830.1750
Certified
limits
N
5
00146197
4,
CSF
8/
13/
86
830.1800
Enforcement
analytical
method
Y
00131546,
00146197
4
830.6302
Color
Y
00131546,
00146197
4
830.6303
Physical
state
Y
00131546,
00146197
4
830.6304
Odor
Y
00131546,
00146197
4
830.6313
Stability
to
normal
and
elevated
temperatures,
metals,
and
metal
ions
N
6
00131546,
00146197
4
830.6314
Oxidation/
reduction:
chemical
incompatibility
Y
00146197
4
830.6315
Flammability
N/
A
7
830.6316
Explodability
Y
00146197
4
830.6317
Storage
stability
N
8
00131546,
00146197
4
830.6319
Miscibility
N/
A
7
830.6320
Corrosion
characteristics
Y
00146197
4
830.7000
pH
Y
00146197
4
830.7050
UV/
Visible
absorption
N
830.7100
Viscosity
N/
A
7
830.7200
Melting
point/
melting
range
Y
00131546,
00146197
4
830.7220
Boiling
point/
boiling
range
N/
A
7
830.7300
Density/
relative
density/
bulk
density
Y
00146197
4
830.7370
Dissociation
constants
in
water
Y
00146197
4
830.7550
Partition
coefficient
(
n­
octanol/
water),
shake
flask
method
Y
00131546,
00146197
4
830.7840
Water
solubility:
column
elution
method;
shake
flask
method
Y
00131546,
00146197
4
830.
xxxx
Solvent
solubility
Y
00146197
4
830.7950
Vapor
pressure
Y
00146197
4
1
Y
=
Yes;
N
=
No;
N/
A
=
Not
Applicable.

2
The
CSF
was
obtained
from
the
product
jacket.
Bolded
references
were
reviewed
under
the
initial
petition
for
temporary
tolerances
(
PP#
4G2979,
memorandum
dated
3/
28/
84,
R.
Loranger);
and
all
other
references
were
reviewed
as
noted.
Imazaquin
TRED:
Product
Chemistry
Considerations
Barcode:
D302940
Page
7
of
13
3
Nominal
concentrations
are
required
for
the
active
ingredient
and
each
impurity
associated
with
the
active
ingredient
that
was
found
to
be
present
in
any
sample
at
$
0.1%.
The
nominal
concentrations
should
represent
the
typical
(
average)
level
determined
in
preliminary
analysis.
In
addition,
we
note
that
the
label
claim
reflects
the
lower
certified
limit
of
the
active
ingredient;
once
a
nominal
concentration
is
assigned,
the
label
claim
should
be
modified
to
agree
with
the
nominal
concentration
of
the
active
ingredient.
We
note
that
the
CSF
includes
three
unidentified
impurities
listed
in
a
group
(
A,
B,
and
F);
based
on
preliminary
analysis
data,
impurity
F
is
present
at
>
0.1%
and
therefore
must
be
identified
or
at
least
characterized.

4
PP#
5F3273;
RCB
No.
1265,
1/
9/
86,
A.
Smith.

5
Single
upper
certified
limits
are
listed
for
one
group
of
seven
identified
impurities
and
for
one
group
of
three
unidentified
impurities.
Individual
upper
certified
limits
must
be
proposed
for
each
impurity
present
at
$
0.1%
in
the
technical
product.

6
Data
demonstrating
the
stability
of
the
TGAI
on
exposure
to
metals
and
metal
ions
are
required.

7
Data
are
not
required
because
the
TGAI
(
T/
MP)
is
a
solid
at
room
temperature.

8
Data
are
required
which
demonstrate
the
stability
of
the
T/
MP
stored
at
ambient
conditions
in
the
typical
storage
container
for
up
to
one
year;
6­
month
storage
stability
data
have
been
submitted.
Imazaquin
TRED:
Product
Chemistry
Considerations
Barcode:
D302940
Page
8
of
13
Case
No.
None
PC
Code
128840
Case
Name:
Imazaquin,
ammonium
salt
Registrant:
BASF
Corporation
Product(
s):
Imazaquin
ammonium
salt
unregistered
TGAI
source
for:
17.3%
EP
(
EPA
Reg.
No.
241­
289),
17.3%
EP
(
EPA
Reg.
No.
241­
292),
17.3%
EP
(
EPA
Reg.
No.
241­
303);
4.72%
EP
(
EPA
Reg.
No.
241­
307);
3.65%
EP
(
EPA
Reg.
No.
241­
327);
0.79%
EP
(
EPA
Reg.
No.
241­
326);
and
0.75%
EP
(
EPA
Reg.
No.
241­
352)

PRODUCT
CHEMISTRY
DATA
SUMMARY
Guideline
Number
Requirement
Are
Data
Requirements
Fulfilled?
1
MRID
Number
2
830.1550
Product
identity
and
composition
N/
A
3
CSFs
830.1600
Description
of
materials
used
to
produce
the
product
N
830.1620
Description
of
production
process
N
830.1670
Discussion
of
formation
of
impurities
N
830.1700
Preliminary
analysis
N
830.1750
Certified
limits
N/
A
3
CSFs
830.1800
Enforcement
analytical
method
N/
A
3
830.6302
Color
N
830.6303
Physical
state
N
830.6304
Odor
N
830.6313
Stability
to
normal
and
elevated
temperatures,
metals,
and
metal
ions
N
830.6314
Oxidation/
reduction:
chemical
incompatibility
N/
A
3
830.6315
Flammability
N/
A
3
830.6316
Explodability
N/
A
3
830.6317
Storage
stability
N/
A
3
830.6319
Miscibility
N/
A
3
830.6320
Corrosion
characteristics
N/
A
3
830.7000
pH
N
830.7050
UV/
visible
absorption
N
830.7100
Viscosity
N/
A
3
830.7200
Melting
point/
melting
range
N
830.7220
Boiling
point/
boiling
range
N
830.7300
Density/
relative
density/
bulk
density
N
830.7370
Dissociation
constants
in
water
N
830.7550
Partition
coefficient
(
n­
octanol/
water),
shake
flask
method
N
830.7840
Water
solubility:
column
elution
method;
shake
flask
method
N
830.
xxxx
Solvent
solubility
N
830.7950
Vapor
pressure
N
1
Y
=
Yes;
N
=
No;
N/
A
=
Not
Applicable.
The
BASF
ammonium
salt
EPs
are
manufactured
by
an
integrated
system
from
an
EPA­
registered
imazaquin
acid
product.
Data
are
required
for
the
isolated
imazaquin
ammonium
salt
TGAI.

2
The
CSFs
were
obtained
from
the
product
jacket.
Imazaquin
TRED:
Product
Chemistry
Considerations
Barcode:
D302940
Page
9
of
13
3
These
data
are
not
required
for
the
TGAI.
Imazaquin
TRED:
Product
Chemistry
Considerations
Barcode:
D302940
Page
10
of
13
Case
No.
None
PC
Code
128840
Case
Name:
Imazaquin,
ammonium
salt
Registrant:
Ambrands
Product(
s):
Imazaquin
ammonium
salt
unregistered
TGAI
source
for
the
3.3%
EP
(
EPA
Reg.
No.
73342­
4)

PRODUCT
CHEMISTRY
DATA
SUMMARY
Guideline
Number
Requirement
Are
Data
Requirements
Fulfilled?
1
MRID
Number
2
830.1550
Product
identity
and
composition
N/
A
3
CSF
1/
18/
01
830.1600
Description
of
materials
used
to
produce
the
product
N
830.1620
Description
of
production
process
N
830.1670
Discussion
of
formation
of
impurities
N
830.1700
Preliminary
analysis
N
830.1750
Certified
limits
N/
A
3
CSF
1/
18/
01
830.1800
Enforcement
analytical
method
N/
A
3
830.6302
Color
N
830.6303
Physical
state
N
830.6304
Odor
N
830.6313
Stability
to
normal
and
elevated
temperatures,
metals,
and
metal
ions
N
830.6314
Oxidation/
reduction:
chemical
incompatibility
N/
A
3
830.6315
Flammability
N/
A
3
830.6316
Explodability
N/
A
3
830.6317
Storage
stability
N/
A
3
830.6319
Miscibility
N/
A
3
830.6320
Corrosion
characteristics
N/
A
3
830.7000
pH
N
830.7050
UV/
visible
absorption
N
830.7100
Viscosity
N/
A
3
830.7200
Melting
point/
melting
range
N
830.7220
Boiling
point/
boiling
range
N
830.7300
Density/
relative
density/
bulk
density
N
830.7370
Dissociation
constants
in
water
N
830.7550
Partition
coefficient
(
n­
octanol/
water),
shake
flask
method
N
830.7840
Water
solubility:
column
elution
method;
shake
flask
method
N
830.
xxxx
Solvent
solubility
N
830.7950
Vapor
pressure
N
1
Y
=
Yes;
N
=
No;
N/
A
=
Not
Applicable.
The
Ambrands
ammonium
salt
EP
is
manufactured
by
an
integrated
system
from
an
EPA­
registered
imazaquin
acid
product.
Data
are
required
for
the
isolated
imazaquin
ammonium
salt
TGAI.

2
The
CSF
was
obtained
from
the
product
jacket.

3
These
data
are
not
required
for
the
TGAI.
Imazaquin
TRED:
Product
Chemistry
Considerations
Barcode:
D302940
Page
11
of
13
Case
No.
None
PC
Code
129023
Case
Name:
Imazaquin,
sodium
salt
Registrant:
BASF
Corporation
Product(
s):
Imazaquin
sodium
salt
unregistered
TGAI
source
for
the
5.6%
EP
(
EPA
Reg.
No.
241­
321)

PRODUCT
CHEMISTRY
DATA
SUMMARY
Guideline
Number
Requirement
Are
Data
Requirements
Fulfilled?
1
MRID
Number
2
830.1550
Product
identity
and
composition
N/
A
3
CSF
11/
27/
96
(
Basic)
CSF
10/
7/
96
(
Alternate)
830.1600
Description
of
materials
used
to
produce
the
product
N
830.1620
Description
of
production
process
N
830.1670
Discussion
of
formation
of
impurities
N
830.1700
Preliminary
analysis
N
830.1750
Certified
limits
N/
A
3
CSF
11/
27/
96
(
Basic)
CSF
10/
7/
96
(
Alternate)
830.1800
Enforcement
analytical
method
N/
A
3
830.6302
Color
N
830.6303
Physical
state
N
830.6304
Odor
N
830.6313
Stability
to
normal
and
elevated
temperatures,
metals,
and
metal
ions
N
830.6314
Oxidation/
reduction:
chemical
incompatibility
N/
A
3
830.6315
Flammability
N/
A
3
830.6316
Explodability
N/
A
3
830.6317
Storage
stability
N/
A
3
830.6319
Miscibility
N/
A
3
830.6320
Corrosion
characteristics
N/
A
3
830.7000
pH
N
830.7050
UV/
visible
absorption
N
830.7100
Viscosity
N
830.7200
Melting
point/
melting
range
N
830.7220
Boiling
point/
boiling
range
N
830.7300
Density/
relative
density/
bulk
density
N
830.7370
Dissociation
constants
in
water
N
830.7550
Partition
coefficient
(
n­
octanol/
water),
shake
flask
method
N
830.7840
Water
solubility:
column
elution
method;
shake
flask
method
N
830.
xxxx
Solvent
solubility
N
830.7950
Vapor
pressure
N
1
Y
=
Yes;
N
=
No;
N/
A
=
Not
Applicable.
The
BASF
sodium
salt
EP
(
EPA
Reg.
No.
241­
321)
is
manufactured
by
an
integrated
system
from
an
EPA­
registered
imazaquin
acid
product.
Data
are
required
for
the
isolated
imazaquin
sodium
salt
TGAI.

2
The
CSFs
were
obtained
from
the
product
jacket.
Imazaquin
TRED:
Product
Chemistry
Considerations
Barcode:
D302940
Page
12
of
13
3
These
data
are
not
required
for
the
TGAI.
Imazaquin
TRED:
Product
Chemistry
Considerations
Barcode:
D302940
Page
13
of
13
BIBLIOGRAPHY
Study
Citations
00131546
American
Cyanamid
Co.
(
1983)
Product
Chemistry:
Scepter
Herbicide.
(
Compilation;
unpublished
study
received
Oct
14,
1983
under
241­
EX­
108;
CDL:
072010­
A)

00146197
American
Cyanamid
Co.
(
1985)
Product
Chemistry:
Scepter
Herbicide.
Unpublished
compilation.
304
p.

Agency
Memoranda
Citations
DP
Barcode(
s):
None
Subject:
PP#
4G2979.
Scepter
on
Soybeans.
Evaluation
of
Analytical
Method
and
Residue
Data.
From:
R.
Loranger
To:
R.
Taylor
and
Toxicology
Branch
Dated:
3/
28/
84
MRID(
s):
00131546
(
Accession
Nos.
072010
and
072013)

DP
Barcode(
s):
None;
RCB
No.
1265
Subject:
PP#
5F3273.
Scepter
in
Soybeans
­
Evaluation
of
Residue
Data
and
Analytical
Method.
From:
A.
Smith
To:
R.
Taylor
and
Toxicology
Branch
Dated:
1/
9/
86
MRID(
s):
00146197
(
Accession
Nos.
073703,
073706
and
073678)
