Imazaquin
Dietary
Exposure
Assessment
DP
Barcode:
D302943
PC
Code:
128848
Page
1
of
13
UNITED
STATES
ENVIRONMENTAL
PROTECTION
AGENCY
WASHINGTON,
D.
C.
20460
OFFICE
OF
PREVENTION,
PESTICIDES
AND
TOXIC
SUBSTANCES
MEMORANDUM
DATE:
10/
20/
2005
SUBJECT:
Imazaquin
Chronic
Dietary
Exposure
Assessment
for
the
Tolerance
Reassessment
Eligibility
Decision
(
TRED)

PC
Code:
128848
DP
Barcode:
D302943
REVIEWER:
Susan
Stanton,
Environmental
Scientist
Reregistration
Branch
III/
Health
Effects
Division
(
7509C)

THROUGH:
Christina
Swartz,
Chief,
RAB2
Thurston
Morton,
Chemist
Dietary
Exposure
Science
Advisory
Council
(
DESAC)
Health
Effects
Division
(
7509C)

and
William
Donovan,
Branch
Senior
Scientist
Branch/
Health
Effects
Division
(
7509C)

TO:
Craig
Doty,
Chemical
Review
Manager
Special
Review
Branch/
Special
Review
and
Reregistration
Division
(
7508C)

Executive
Summary
A
chronic
dietary
risk
assessment
was
conducted
for
the
herbicide,
imazaquin,
using
the
Dietary
Exposure
Evaluation
Model
(
DEEM­
FCID,
Version
2.03),
which
uses
food
consumption
data
from
the
USDA's
Continuing
Surveys
of
Food
Intakes
by
Individuals
(
CSFII)
from
1994­
1996
and
1998.
The
analysis
was
performed
to
support
the
imazaquin
Tolerance
Reassessment
Eligibility
Decision
(
TRED).
Imazaquin
Dietary
Exposure
Assessment
DP
Barcode:
D302943
PC
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Page
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No
toxic
effects
attributable
to
a
single
(
i.
e.,
acute)
exposure
have
been
identified;
therefore,
an
acute
Reference
Dose
(
RfD)
has
not
been
established
for
imazaquin
and
an
acute
dietary
exposure
assessment
has
not
been
conducted.
Also,
since
there
is
no
evidence
that
imazaquin
is
carcinogenic
to
humans,
a
dietary
cancer
assessment
was
not
conducted.

Chronic
Dietary
Exposure
Results
and
Characterization
Imazaquin
is
registered
for
a
single
food
use
on
soybeans.
The
tier
1
chronic
assessment
assumed
that
100%
of
the
soybean
crop
is
treated
and
that
residues
of
imazaquin
are
present
at
the
tolerance
level
of
0.05
ppm
in
all
soybean
commodities,
including
processed
commodities.
Drinking
water
was
incorporated
directly
into
the
dietary
assessment
using
the
tier
1
estimated
drinking
water
concentration
(
EDWC)
for
ground
water
generated
by
the
SCI­
GROW
model.

The
resulting
dietary
exposure
estimates
are
well
below
HED's
level
of
concern
(
i.
e.,
<
100%
of
the
cPAD)
for
the
overall
U.
S.
population
and
all
population
subgroups.
Using
the
DEEM­
FCID
software,
dietary
exposure
is
estimated
at
0.000677
mg/
kg/
day
for
the
U.
S.
population
(
0.3%
of
the
cPAD)
and
0.002208
mg/
kg/
day
(
0.9%
of
the
cPAD)
for
infants
less
than
1
year
old,
the
population
subgroup
with
the
highest
estimated
chronic
dietary
exposure
to
imazaquin.

More
than
95%
of
the
total
estimated
dietary
exposure
is
from
drinking
water.

I.
Introduction
Dietary
risk
assessment
incorporates
both
exposure
and
toxicity
of
a
given
pesticide.
For
chronic
assessments,
the
risk
is
expressed
as
a
percentage
of
a
maximum
acceptable
dose
(
i.
e.,
the
dose
which
HED
has
concluded
will
result
in
no
unreasonable
adverse
health
effects).
This
dose
is
referred
to
as
the
chronic
population
adjusted
dose
(
cPAD).
The
cPAD
is
equivalent
to
the
Reference
Dose
(
RfD)
divided
by
the
special
FQPA
Safety
Factor.

For
chronic
exposures,
HED
is
concerned
when
estimated
dietary
risk
exceeds
100%
of
the
cPAD.
References
which
discuss
the
chronic
risk
assessment
in
more
detail
are
available
on
the
EPA/
pesticides
web
site:
"
Available
Information
on
Assessing
Exposure
from
Pesticides,
A
User's
Guide,"
6/
21/
2000,
web
link:
http://
www.
epa.
gov/
fedrgstr/
EPA­
PEST/
2000/
July/
Day­
12/
6061.
pdf
;
or
see
SOP
99.6
(
8/
20/
99).

The
only
previous
dietary
assessment
for
imazaquin
that
is
available
in
HED's
records
is
an
assessment
(
dated
3/
9/
94)
without
an
accompanying
memorandum
which
was
done
using
the
Dietary
Risk
Evaluation
System
(
DRES)
model.
This
assessment
estimated
chronic
exposure
and
risk
from
tolerance
level
residues
of
0.05
ppm
in/
on
soybean
commodities,
and
was
based
on
an
Imazaquin
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Exposure
Assessment
DP
Barcode:
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RfD
of
0.25
mg/
kg/
day
(
same
as
in
the
current
assessment).
Estimated
exposures
for
the
U.
S.
population
and
all
population
subgroups
were
less
than
0.01%
of
the
RfD.

II.
Residue
Information
Residues
of
Concern:
The
imazaquin
review
team
has
determined
that
for
tolerance
enforcement
and
risk
assessment
purposes,
the
residues
of
concern
in
plants,
livestock
and
drinking
water
are
as
follows:

Plants:
The
nature
of
the
residue
in
plants
is
adequately
understood
for
the
use
of
imazaquin
on
soybeans.
Based
on
the
trace
levels
of
radioactivity
found
in
the
soybean
seed
from
an
exaggerated
application
rate,
the
apparent
extensive
degradation
of
imazaquin
into
plant
constituents,
and
the
livestock
grazing/
feeding
prohibition
of
forage,
straw
and
hay
on
current
labels,
the
residue
of
concern
for
the
use
of
imazaquin
on
soybeans
is
imazaquin,
per
se.
There
are
no
other
food
uses
of
imazaquin.

Livestock:
Tolerances
for
imazaquin
residues
in
livestock
commodities
are
not
required
as
a
result
of
the
use
on
soybeans.
This
determination
is
based
on
the
absence
of
detectable
residues
in
eggs,
milk,
and
livestock
tissues
from
the
available
animal
metabolism
studies
and
the
absence
of
detectable
residues
in
the
submitted
magnitude
of
residue
studies
for
livestock
feedstuffs.
Additionally,
label
restrictions
prohibit
the
grazing
or
feeding
of
soybean
forage,
hay
or
straw
to
livestock.
Residue
data
have
not
been
submitted
for
the
animal
feedstuff,
aspirated
grain
fractions;
however,
they
are
not
required
since
imazaquin
is
applied
early
in
the
growing
season
(
before
the
reproduction
stage
begins)
and
detectable
residues
are
not
expected
in
the
seed.
If
additional
uses
or
additional
field
studies
result
in
detectable
residues
in
feedstuffs,
then
additional
animal
metabolism
studies
may
be
required.
The
residue
of
concern
in
livestock
commodities
will
be
determined
if/
when
tolerances
for
secondary
residues
in
livestock
commodities
are
deemed
necessary.

Drinking
Water:
Aqueous
photolysis
is
the
only
significant
degradation
pathway
for
imazaquin
and
leads
to
four
major
degradates
of
greater
than
10%
of
the
applied
amount
(
3­
quinolinecarboxylic
acid;
2,3
quinolinedicarboxylic
acid
imide;
2,3
dihydro­
3­
imino­
1H­
pyrrolo­[
3,4­
b]
quinoline­
1­
one;
and
2,3
quinolinedicarboxylic
acid).
These
degradates
are
expected
to
form
in
surface
water
only.
They
are
not
expected
to
form
in
groundwater,
since
the
parent
compound
is
not
exposed
to
light
and
aqueous
photolysis
does
not
occur.

HED
has
determined
that
the
surface
water
degradates
of
imazaquin
have
the
potential
to
be
toxicologically
equivalent
to
the
parent
compound;
therefore,
the
residues
of
concern
for
risk
assessment
purposes
in
surface
water
include
imazaquin,
3­
quinolinecarboxylic
acid;
2,3
Imazaquin
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Exposure
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quinolinedicarboxylic
acid
imide;
2,3
dihydro­
3­
imino­
1H­
pyrrolo­[
3,4­
b]
quinoline­
1­
one;
and
2,3
quinolinedicarboxylic
acid.
The
residues
of
concern
in
ground
water
include
parent
imazaquin
only.

Tolerances:
A
tolerance
of
0.05
ppm
has
been
established
under
40
CFR
§
180.426
for
residues
of
imazaquin,
2­[
4,5­
dihydro­
4­
methyl­
4­(
1­
methylethyl)­
5­
oxo­
1Himidazol­
2­
yl]­
3­
quinoline
carboxylic
acid,
in
or
on
soybeans.
HED
has
reassessed
the
tolerance
and
determined
that
it
should
be
maintained
at
its
current
level.
Residues
in
livestock
commodities
may
be
classified
under
40
CFR
§
180.6(
a)(
3);
i.
e.,
no
expectation
of
finite
residues.
Thus,
tolerances
for
livestock
commodities
are
not
needed
at
this
time.

Residue
Data
used
for
the
Chronic
Assessment:

Food:
The
tier
1
chronic
assessment
assumed
that
100%
of
the
soybean
crop
is
treated
and
that
residues
of
imazaquin
are
present
at
the
tolerance
level
of
0.05
ppm
in
all
soybean
commodities,
including
processed
commodities.

Drinking
Water:
Reference:
Drinking
Water
Assessment
for
Imazaquin
and
its
Salts;
K.
Moore;
June
21,
2005,
as
amended
on
September
27,
2005.

Potential
concentrations
of
imazaquin
and
its
monoammonium
and
monosodium
salts
in
drinking
water
were
assessed
by
the
Environmental
Fate
and
Effects
Division
(
EFED)
through
an
evaluation
of
surface
water
and
groundwater
monitoring
data
and
modeling.
Because
all
three
compounds
dissociate
in
water
to
form
the
carboxylate
anion,
they
were
treated
concurrently
in
the
assessment.

Imazaquin's
primary
use
is
as
a
broad
spectrum
herbicide
on
soybeans.
The
turf
and
ornamental
use
patterns
were
also
considered
in
EFED's
assessment.
Surface
and
groundwater
monitoring
data
were
available
from
the
United
States
Geological
Survey
(
USGS)
National
Water­
Quality
Assessment
(
NAWQA)
Program
and
from
an
additional
USGS
study
on
pesticide
concentrations
in
high
use
areas
in
the
Midwest.
Maximum
concentrations
of
imazaquin
in
the
monitoring
data
reviewed
were
4.89
:
g
ae/
L
in
surface
water
and
0.098
:
g
ae/
L
in
groundwater.
Because
the
monitoring
studies
reviewed
are
short
term
or
not
targeted
to
detect
imazaquin,
they
are
not
likely
to
capture
peak
concentrations.
Modeling
was
used,
therefore,
to
predict
the
most
conservative
concentrations,
with
monitoring
data
used
to
confirm
that
modeling
results
are
reasonable.
EECs
in
surface
water
were
modeled
using
PRZM
3.12/
EXAMS
2.98.04,
and
ground
water
concentrations
were
modeled
using
SCIGROW
(
version
2.3).

At
the
time
of
EFED's
original
assessment,
no
degradates
of
concern
had
been
identified
and
only
the
parent
compounds
(
imazaquin
and
its
monoammonium
and
sodium
salts)
were
assessed.
Imazaquin
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HED
subsequently
determined
that
the
major
surface
water
degradates
should
also
be
considered
in
the
risk
assessment
(
See
above).
Therefore,
EFED
repeated
the
surface
water
modeling
for
the
most
vulnerable
scenario,
turf,
with
an
updated
photolysis
half­
life
that
incorporated
these
degradates.
The
updated,
total
residue
half­
life
was
calculated
by
performing
first
order
linear
regression
on
the
log
transformed
sum
total
of
imazaquin
plus
each
of
the
four
major
degradates
at
each
sampling
point.
The
surface
and
ground
water
modeling
results
are
presented
in
Table
1.
Note
that
all
concentrations
reported
in
this
assessment
are
in
acid
equivalents
(
ae)
unless
otherwise
specified.

Table
1.
Imazaquin
EECs
1
Surface
water
(
PRZM
/
EXAMS)
Groundwater
(
SCIGROW)

Acute
(
Peak)
Chronic
(
Annual
average)
Acute
&
Chronic
Soybeans
1.8
µ
g
ae/
L
0.4
µ
g
ae/
L
3.8
µ
g
ae/
L
Ornamental
1.9
µ
g
ae/
L
1.0
µ
g
ae/
L
15.6
µ
g
ae/
L
Turf
­
1
app.
15.2
µ
g
ae/
L
5.0
µ
g
ae/
L
15.6
µ
g
ae/
L
Turf
­
1
app.
2
16.0
µ
g
ae/
L
6.7
µ
g
ae/
L
15.6
µ
g
ae/
L
Turf
­
2
app.
20.0
µ
g
ae/
L
7.6
µ
g
ae/
L
31.1
µ
g
ae/
L
Turf
­
2
app.
2
21.8
µ
g
ae/
L
11.6
µ
g
ae/
L
31.1
µ
g
ae/
L
1
All
EECs
are
for
parent
compound
only,
unless
otherwise
specified.
2
The
surface
water
EECs
include
parent
imazaquin
and
its
major
degradates.
The
ground
water
EECs
include
parent
compound
only.

The
highest
imazaquin
concentration
was
estimated
for
groundwater,
based
on
2
applications
to
turf
at
0.5
lbs.
ae/
acre.
This
value
(
31.1
ppb/
0.031
ppm)
was
used
as
a
point
estimate
to
assess
exposure
to
imazaquin
from
drinking
water
in
the
dietary
assessment.

III.
DEEM­
FCID
 
Program
and
Consumption
Information
A
chronic
dietary
exposure
assessment
for
imazaquin
was
conducted
using
the
Dietary
Exposure
Evaluation
Model
software
with
the
Food
Commodity
Intake
Database
(
DEEM­
FCID
 
,
Version
2.03),
which
incorporates
consumption
data
from
USDA's
Continuing
Surveys
of
Food
Intakes
by
Individuals
(
CSFII),
1994­
1996
and
1998.
The
1994­
96/
98
data
are
based
on
the
reported
consumption
of
more
than
20,000
individuals
over
two
non­
consecutive
survey
days.
Foods
"
as
consumed"
(
e.
g.,
apple
pie)
are
linked
to
EPA­
defined
food
commodities
(
e.
g.
apples,
peeled
fruit
­
cooked;
fresh
or
N/
S;
baked;
or
wheat
flour
­
cooked;
fresh
or
N/
S,
baked)
using
publicly
available
recipe
translation
files
developed
jointly
by
USDA/
ARS
and
EPA.
For
chronic
exposure
assessment,
consumption
data
are
averaged
for
the
entire
U.
S.
population
and
within
population
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subgroups.
Based
on
analysis
of
the
1994­
96,
98
CSFII
consumption
data,
which
took
into
account
dietary
patterns
and
survey
respondents,
HED
concluded
that
it
is
most
appropriate
to
report
risk
for
the
following
population
subgroups:
the
general
U.
S.
population,
all
infants
(<
1
year
old),
children
1­
2,
children
3­
5,
children
6­
12,
youth
13­
19,
adults
20­
49,
females
13­
49,
and
adults
50+
years
old.

For
chronic
dietary
exposure
assessment,
an
estimate
of
the
residue
level
in
each
food
or
foodform
(
e.
g.,
orange
or
orange
juice)
on
the
food
commodity
residue
list
is
multiplied
by
the
average
daily
consumption
estimate
for
that
food/
food
form.
The
resulting
residue
consumption
estimate
for
each
food/
food
form
is
summed
with
the
residue
consumption
estimates
for
all
other
food/
food
forms
on
the
commodity
residue
list
to
arrive
at
the
total
average
estimated
exposure.
Exposure
is
expressed
in
mg/
kg
body
weight/
day
and
as
a
percent
of
the
cPAD.
This
procedure
is
performed
for
each
population
subgroup.

IV.
Toxicological
Information
Imazaquin
has
relatively
low
toxicity,
with
a
chronic
RfD
(
and
cPAD)
of
0.25
mg/
kg/
day.
The
RfD
is
based
on
the
NOAEL
of
25
mg/
kg
from
a
chronic
toxicity
feeding
study
in
the
dog
and
a
100­
fold
inter­/
intra­
species
uncertainty
factor.
The
FQPA
safety
factor
has
been
reduced
to
1x,
based
on
the
lack
of
evidence
of
pre­
and/
or
postnatal
susceptibility
resulting
following
exposure
to
imazaquin
and
considering
the
lack
of
residual
uncertainties
for
pre­
and/
or
postnatal
toxicity.

An
endpoint
of
concern
attributable
to
a
single
dose
was
not
identified
for
imazaquin;
therefore,
an
acute
RfD
was
not
established
and
an
acute
dietary
assessment
was
not
conducted.
In
addition,
no
evidence
of
carcinogenicity
was
seen
in
studies
in
mice
or
rats.
Therefore,
a
cancer
dietary
exposure
assessment
was
not
conducted.

Table
2.
Summary
of
Toxicological
Doses
and
Endpoints
for
Imazaquin
for
Use
in
Dietary
Exposure
Assessment
Exposure
Scenario
Dose
Used
in
Risk
Assessment,
UF
Hazard
and
Exposure
Based
Special
FQPA
Safety
Factor
Study
and
Toxicological
Effects
Acute
Dietary
(
females
13­
49)
None
selected.
No
evidence
of
relevant
toxicity
following
a
single
dose.

Acute
Dietary
(
general
population)
Imazaquin
Dietary
Exposure
Assessment
DP
Barcode:
D302943
PC
Code:
128848
Table
2.
Summary
of
Toxicological
Doses
and
Endpoints
for
Imazaquin
for
Use
in
Dietary
Exposure
Assessment
Exposure
Scenario
Dose
Used
in
Risk
Assessment,
UF
Hazard
and
Exposure
Based
Special
FQPA
Safety
Factor
Study
and
Toxicological
Effects
Page
7
of
13
Chronic
Dietary
(
all
populations)
NOAEL
=
25
mg/
kg/
day
UF
=
100
Chronic
RfD
=
0.25
mg/
kg/
day
FQPA
SF
=
1
cPAD
=
chronicRfD
FQPA
SF
=
0.25
mg/
kg/
day
Chronic
toxicity
­
dog
LOAEL
=
125
mg/
kg/
day
based
on
weight
loss,
slight
anemia,
evidence
of
skeletal
muscle
myopathy
and
supporting
hematology/
clinical
chemistry
differences
Cancer
Classification:
no
evidence
of
carcinogenicity
in
mice
or
rats.
"
Not
Likely
To
Be
Carcinogenic
To
Humans".

V.
Results/
Discussion
As
stated
above,
for
a
chronic
assessment,
HED
is
concerned
when
dietary
risk
exceeds
100%
of
the
cPAD.
The
DEEM­
FCID
 
analysis
estimates
the
dietary
exposure
of
the
U.
S.
population
and
various
population
subgroups.
The
results
reported
in
Table
3
are
for
the
general
U.
S.
population,
all
infants
(<
1
year
old),
children
1­
2,
children
3­
5,
children
6­
12,
youth
13­
19,
females
13­
49,
adults
20­
49,
and
adults
50+
years.
Imazaquin
chronic
dietary
exposure
(
food
+
water)
estimates
using
the
DEEM­
FCID
 
software
were
less
than
1.0%
of
the
cPAD
for
the
U.
S.
population
and
each
of
the
population
subgroups.
Dietary
exposure
was
estimated
at
0.000677
mg/
kg/
day
for
the
U.
S.
population
(
0.3%
of
the
cPAD)
and
0.002208
mg/
kg/
day
(
0.9%
of
the
cPAD)
for
the
most
highly
exposed
population
subgroup
(
infants,
less
than
1
year
old).
More
than
95%
of
the
total
estimated
dietary
exposure
is
from
drinking
water.

Table
3.
Summary
of
Chronic
Dietary
Exposure
and
Risk
for
Imazaquin1
Population
Subgroup
Food
Only
Drinking
Water
Only
Total
Exposure
(
mg/
kg/
day)
%
cPAD
Exposure
(
mg/
kg/
day)
%
cPAD
Exposure
(
mg/
kg/
day)
%
cPAD
General
U.
S.
Population
0.000024
0.01
0.000653
0.3
0.000677
0.3
All
Infants
(<
1
year
old)
0.000066
0.03
0.002142
0.9
0.002208
0.9
Children
1­
2
years
old
0.000053
0.02
0.000970
0.4
0.001023
0.4
Children
3­
5
years
old
0.000052
0.02
0.000908
0.4
0.000960
0.4
Imazaquin
Dietary
Exposure
Assessment
DP
Barcode:
D302943
PC
Code:
128848
Table
3.
Summary
of
Chronic
Dietary
Exposure
and
Risk
for
Imazaquin1
Population
Subgroup
Food
Only
Drinking
Water
Only
Total
Exposure
(
mg/
kg/
day)
%
cPAD
Exposure
(
mg/
kg/
day)
%
cPAD
Exposure
(
mg/
kg/
day)
%
cPAD
Page
8
of
13
Children
6­
12
years
old
0.000036
0.01
0.000627
0.3
0.000663
0.3
Youth
13­
19
years
old
0.000023
0.01
0.000472
0.2
0.000496
0.2
Adults
20­
49
years
old
0.000019
0.01
0.000610
0.2
0.000629
0.3
Adults
50+
years
old
0.000015
0.01
0.000642
0.3
0.000657
0.3
Females
13­
49
years
old
0.000018
0.01
0.000608
0.2
0.000626
0.3
1The
population
subgroup
with
the
highest
estimated
chronic
exposure
and
risk
is
indicated
by
bold
text..

VI.
Characterization
of
Inputs/
Outputs
These
chronic
dietary
exposure
and
risk
estimates
are
conservative
since
they
assumed
100%
crop
treated
and
tolerance­
level
residues
and
were
based
on
screening
level
estimates
of
drinking
water
concentrations
generated
by
the
SCI­
GROW
model.
They
could
be
further
refined
through
the
use
of
anticipated
residues
and
percent
crop
treated
data,
as
well
as
refined
drinking
water
estimates.
However,
since
estimated
exposures
and
risks
using
conservative
assumptions
are
well
below
HED's
level
of
concern,
such
refinement
is
not
warranted.

VII.
Conclusions
This
Tier
1
chronic
dietary
exposure
analysis
using
DEEM­
FCID
 
indicates
that
chronic
dietary
exposure
to
imazaquin
from
food
and
drinking
water
is
well
below
HED's
level
of
concern
for
this
pesticide.
Estimated
chronic
dietary
exposures
are
less
than
1%
of
the
cPAD
for
the
general
U.
S.
population
and
all
population
subgroups.

VIII.
List
of
Attachments
°
Chronic
Food
Residue
Input
file.
°
Chronic
Results
file.
°
Commodity
Contribution
Reports
for
U.
S.
Population
and
Infants
Imazaquin
Dietary
Exposure
Assessment
DP
Barcode:
D302943
PC
Code:
128848
Page
9
of
13
U.
S.
Environmental
Protection
Agency
Ver.
2.00
DEEM­
FCID
Chronic
analysis
for
IMAZAQUIN
1994­
98
data
Residue
file:
C:\
DEEMFCID\
Imazaquin\
ImazaquinChronicFood+
Water.
R98
Adjust.
#
2
NOT
used
Analysis
Date
09­
21­
2005
Residue
file
dated:
09­
21­
2005/
10:
09:
34/
8
Reference
dose
(
RfD)
=
0.25
mg/
kg
bw/
day
Comment:
Chronic
Food
(
soybean)
plus
Water;
cPAD
=
0.25
mg/
kg/
day
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Food
Crop
Residue
Adj.
Factors
Comment
EPA
Code
Grp
Food
Name
(
ppm)
#
1
#
2
­­­­­­­­
­­­­
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­
­­­­­­
­­­­­­
­­­­­­­
06003470
6
Soybean,
seed
0.050000
1.000
1.000
06003480
6
Soybean,
flour
0.050000
1.000
1.000
06003481
6
Soybean,
flour­
babyfood
0.050000
1.000
1.000
06003490
6
Soybean,
soy
milk
0.050000
1.000
1.000
06003491
6
Soybean,
soy
milk­
babyfood
or
in
0.050000
1.000
1.000
06003500
6
Soybean,
oil
0.050000
1.000
1.000
06003501
6
Soybean,
oil­
babyfood
0.050000
1.000
1.000
86010000
O
Water,
direct,
all
sources
0.031000
1.000
1.000
86020000
O
Water,
indirect,
all
sources
0.031000
1.000
1.000
Imazaquin
Dietary
Exposure
Assessment
DP
Barcode:
D302943
PC
Code:
128848
Page
10
of
13
U.
S.
Environmental
Protection
Agency
Ver.
2.00
DEEM­
FCID
Chronic
analysis
for
IMAZAQUIN
(
1994­
98
data)
Residue
file
name:
C:\
DEEMFCID\
Imazaquin\
ImazaquinChronicFood+
Water.
R98
Adjustment
factor
#
2
NOT
used.
Analysis
Date
09­
21­
2005/
10:
11:
33
Residue
file
dated:
09­
21­
2005/
10:
09:
34/
8
Reference
dose
(
RfD,
Chronic)
=
.25
mg/
kg
bw/
day
COMMENT
1:
Chronic
Food
(
soybean)
plus
Water;
cPAD
=
0.25
mg/
kg/
day
===============================================================================
Total
exposure
by
population
subgroup
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Total
Exposure
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Population
mg/
kg
Percent
of
Subgroup
body
wt/
day
Rfd
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­­­­
­­­­­­­­­­­­­­­
U.
S.
Population
(
total)
0.000677
0.3%

U.
S.
Population
(
spring
season)
0.000671
0.3%
U.
S.
Population
(
summer
season)
0.000725
0.3%
U.
S.
Population
(
autumn
season)
0.000655
0.3%
U.
S.
Population
(
winter
season)
0.000656
0.3%

Northeast
region
0.000618
0.2%
Midwest
region
0.000685
0.3%
Southern
region
0.000644
0.3%
Western
region
0.000774
0.3%

Hispanics
0.000766
0.3%
Non­
hispanic
whites
0.000660
0.3%
Non­
hispanic
blacks
0.000645
0.3%
Non­
hisp/
non­
white/
non­
black
0.000832
0.3%

All
infants
(<
1
year)
0.002208
0.9%
Nursing
infants
0.000815
0.3%
Non­
nursing
infants
0.002737
1.1%
Children
1­
6
yrs
0.000964
0.4%
Children
7­
12
yrs
0.000628
0.3%

Females
13­
19
(
not
preg
or
nursing)
0.000480
0.2%
Females
20+
(
not
preg
or
nursing)
0.000668
0.3%
Females
13­
50
yrs
0.000651
0.3%
Females
13+
(
preg/
not
nursing)
0.000657
0.3%
Females
13+
(
nursing)
0.000927
0.4%

Males
13­
19
yrs
0.000507
0.2%
Males
20+
yrs
0.000605
0.2%
Seniors
55+
0.000656
0.3%

Children
1­
2
yrs
0.001023
0.4%
Children
3­
5
yrs
0.000960
0.4%
Children
6­
12
yrs
0.000663
0.3%
Youth
13­
19
yrs
0.000496
0.2%
Adults
20­
49
yrs
0.000629
0.3%
Adults
50+
yrs
0.000657
0.3%
Imazaquin
Dietary
Exposure
Assessment
DP
Barcode:
D302943
PC
Code:
128848
Page
11
of
13
Females
13­
49
yrs
0.000626
0.3%

­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­

U.
S.
Environmental
Protection
Agency
Ver.
2.00
DEEM­
FCID
Chronic
analysis
for
IMAZAQUIN
(
1994­
98
data)
Residue
file
name:
C:\
DEEMFCID\
Imazaquin\
ImazaquinChronicFood+
Water.
R98
Adjustment
factor
#
2
NOT
used.
Analysis
Date
09­
21­
2005/
10:
11:
38
Residue
file
dated:
09­
21­
2005/
10:
09:
34/
8
Reference
dose
(
RfD,
Chronic)
=
.25
mg/
kg
bw/
day
COMMENT
1:
Chronic
Food
(
soybean)
plus
Water;
cPAD
=
0.25
mg/
kg/
day
===============================================================================
Complete
commodity
contribution
analysis
for
U.
S.
Population
(
total)
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­

Crop
Group
=
(
O)
Other
Exposure
Analysis
­­­­­­­­­­­­­­­­­­­­­­­
Residue
Adjustment
mg/
kg
Percent
of
Food
Name
(
ppm)
Factors
body
wt/
day
RfD
­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­
­­­­­­­­­­­­­
­­­­­­­­­­­
­­­­­­­­­­
Water,
direct,
all
sources
(
86010000):
FoodForm
N/
S
0.031000
1.000
1.000
0.0003762
0.2%
Water,
indirect,
all
sources
(
86020000):
FoodForm
N/
S
0.031000
1.000
1.000
0.0002772
0.1%
­­­­­­­­­­­
­­­­­­­­­­
Crop
group
subtotal
0.0006534
0.3%

Crop
Group
=
(
6)
Legume
Vegetables
(
Succulent
or
Dried)
Exposure
Analysis
­­­­­­­­­­­­­­­­­­­­­­­
Residue
Adjustment
mg/
kg
Percent
of
Food
Name
(
ppm)
Factors
body
wt/
day
RfD
­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­
­­­­­­­­­­­­­
­­­­­­­­­­­
­­­­­­­­­­
Soybean,
seed
(
06003470):
FoodForm
N/
S
0.050000
1.000
1.000
0.0000002
0.0%
Soybean,
flour
(
06003480):
FoodForm
N/
S
0.050000
1.000
1.000
0.0000006
0.0%
Soybean,
flour­
babyfood
(
06003481):
FoodForm
N/
S
0.050000
1.000
1.000
0.0000002
0.0%
Soybean,
soy
milk
(
06003490):
FoodForm
N/
S
0.050000
1.000
1.000
0.0000011
0.0%
Soybean,
soy
milk­
babyfood
or
infant
fo
(
06003491):
FoodForm
N/
S
0.050000
1.000
1.000
no
exposure
Soybean,
oil
(
06003500):
FoodForm
N/
S
0.050000
1.000
1.000
0.0000208
0.0%
Soybean,
oil­
babyfood
(
06003501):
FoodForm
N/
S
0.050000
1.000
1.000
0.0000007
0.0%
­­­­­­­­­­­
­­­­­­­­­­
Crop
group
subtotal
0.0000236
0.0%

Population
subgroup
total
0.0006770
0.3%
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Imazaquin
Dietary
Exposure
Assessment
DP
Barcode:
D302943
PC
Code:
128848
Page
12
of
13
1
U.
S.
Environmental
Protection
Agency
Ver.
2.00
DEEM­
FCID
Chronic
analysis
for
IMAZAQUIN
(
1994­
98
data)
Residue
file
name:
C:\
DEEMFCID\
Imazaquin\
ImazaquinChronicFood+
Water.
R98
Adjustment
factor
#
2
NOT
used.
Analysis
Date
09­
21­
2005/
10:
11:
38
Residue
file
dated:
09­
21­
2005/
10:
09:
34/
8
Reference
dose
(
RfD,
Chronic)
=
.25
mg/
kg
bw/
day
COMMENT
1:
Chronic
Food
(
soybean)
plus
Water;
cPAD
=
0.25
mg/
kg/
day
===============================================================================
Complete
commodity
contribution
analysis
for
All
infants
(<
1
year)
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­

Crop
Group
=
(
O)
Other
Exposure
Analysis
­­­­­­­­­­­­­­­­­­­­­­­
Residue
Adjustment
mg/
kg
Percent
of
Food
Name
(
ppm)
Factors
body
wt/
day
RfD
­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­
­­­­­­­­­­­­­
­­­­­­­­­­­
­­­­­­­­­­
Water,
direct,
all
sources
(
86010000):
FoodForm
N/
S
0.031000
1.000
1.000
0.0002854
0.1%
Water,
indirect,
all
sources
(
86020000):
FoodForm
N/
S
0.031000
1.000
1.000
0.0018568
0.7%
­­­­­­­­­­­
­­­­­­­­­­
Crop
group
subtotal
0.0021422
0.9%

Crop
Group
=
(
6)
Legume
Vegetables
(
Succulent
or
Dried)
Exposure
Analysis
­­­­­­­­­­­­­­­­­­­­­­­
Residue
Adjustment
mg/
kg
Percent
of
Food
Name
(
ppm)
Factors
body
wt/
day
RfD
­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­
­­­­­­­­­­­­­
­­­­­­­­­­­
­­­­­­­­­­
Soybean,
seed
(
06003470):
FoodForm
N/
S
0.050000
1.000
1.000
0.0000000
0.0%
Soybean,
flour
(
06003480):
FoodForm
N/
S
0.050000
1.000
1.000
0.0000002
0.0%
Soybean,
flour­
babyfood
(
06003481):
FoodForm
N/
S
0.050000
1.000
1.000
0.0000149
0.0%
Soybean,
soy
milk
(
06003490):
FoodForm
N/
S
0.050000
1.000
1.000
no
exposure
Soybean,
soy
milk­
babyfood
or
infant
fo
(
06003491):
FoodForm
N/
S
0.050000
1.000
1.000
no
exposure
Soybean,
oil
(
06003500):
FoodForm
N/
S
0.050000
1.000
1.000
0.0000058
0.0%
Soybean,
oil­
babyfood
(
06003501):
FoodForm
N/
S
0.050000
1.000
1.000
0.0000451
0.0%
­­­­­­­­­­­
­­­­­­­­­­
Crop
group
subtotal
0.0000660
0.0%
Imazaquin
Dietary
Exposure
Assessment
DP
Barcode:
D302943
PC
Code:
128848
Page
13
of
13
Population
subgroup
total
0.0022082
0.9%
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
