1
Screening­
Level
Exposure
Assessment
for
Residential
Uses
for
ethylenediaminetetraacetic
acid
(
EDTA)
(
CAS
Reg.
No.
60­
00­
4)
and
ethylenediaminetetraacetic
acid,
tetrasodium
salt
(
CAS
Reg.
No.
64­
02­
8)

EDTA
and
the
tetrasodium
salt
both
can
be
used
in
pesticide
products
although
the
tolerance
exemptions
specify
use
limitations.

EDTA
and
the
tetrasodium
salt
can
also
be
used
in
food
contact
surface
sanitizing
solutions.

EDTA
has
historically
been
used
medically
for
the
treatment
of
heavy
metal
poisoning.
EDTA
is
also
used
as
a
chelating
agent
in
boiler
and
cooling
water,
in
nickel
plating,
and
in
wood
pulping
processes.
EDTA
is
also
in
detergents
for
household
and
textile
use,
industrial
germicides,
metal
cutting
fluids,
pharmaceuticals,
cosmetics,
and
is
used
as
a
bleaching
agent
in
color
film
processing,
etching
agent
in
metal
finishing
and
semiconductor
production,
activator
in
butadiene­
styrene
co­
polymerization,
in
gas
scrubbing,
and
as
a
component
of
blood
anticoagulants.

CEM
Scenarios:
Laundry
detergent,
General
purpose
cleaner,
Cosmetics
Other
Scenarios:
Food
contact
surface
sanitizing
solutions
Weight
fractions
50th
percentile:
0.05
90th
percentile:
0.05
EDTA
Tetrasodium
Salt
CAS
Number:
60­
00­
4
64­
02­
8
Molecular
Weight:
292.245
380.17248
In
CEM,
a
vapor
pressure
is
needed
to
estimate
inhalation
exposure.
The
vapor
pressures
could
not
be
located
for
either
of
these
chemicals.
However,
the
following
was
located:

°
The
vapor
pressure
of
EDTA
at
20
/

C
was
reported
as
negligible
from
one
source
(
Journal
of
Chemical
Education;
Vol.
79
No.
4
April
2002;
JChemEd.
chem.
wisc.
edu).
°
An
MSDS
for
"
Formula
40"
produced
by
Riverdale
listed
the
vapor
pressure
of
that
product
as
less
than
1
x
10­
7
mm
Hg
@
20
oC
(
non­
volatile).
Formula
40
contains
40
percent
EDTA.
°
No
sources
of
vapor
pressure
information
were
located
for
the
tetrasodium
salt.

Based
on
this
information,
the
value
of
1
x
10­
7
mm
Hg
was
used
as
an
approximate
value
for
the
vapor
pressure
for
EDTA.
Alternatively,
the
inhalation
exposure
could
be
removed
from
the
EDTA
report.
Inhalation
exposures
were
not
evaluated
for
the
tetrasodium
salt.
2
Summary
of
Scenarios
Used
for
EDTA
Risk
Assessments
Use
Scenario
Summary
of
methodology/
sources
General
purpose
cleaner
Used
CEM
generic
scenario
with
default
parameters.

Laundry
detergent
Used
CEM
generic
scenario
with
default
parameters.

Cosmetics
Used
CEM
user­
defined
scenario
with
the
following
parameters:
Amount
retained
on
skin
­
1.9e­
06
g/
cm2­
event
(
bar
soap
value
from
CEM)
Years
of
Use
­
Used
50,
based
on
scientific
judgement
Frequency
of
Use
­
365
days/
year
(
upper
90th
percentile
frequency
of
use
for
foundations
­
EFH,
1999)
Surface
Area
to
Body
Weight
Ratio
­
calculated
from
values
in
EFH,
1999
­
half
of
mean
adult
female
head
surface
area
divided
by
mean
adult
female
body
weight.

Food
contact
surface
sanitizing
solutions
Inhalation
and
dermal
exposure
estimates
are
the
same
as
those
for
general
purpose
cleaners.
Ingestion
exposure
calculated
based
on
the
assumption
that
food
contact
surface
sanitizing
solutions
can
include
products
such
as
dish
washing
detergents.
See
page
11
for
details.

Summary
of
Scenarios
Used
for
EDTA
(
Tetrasodium
Salt)
Risk
Assessments
Use
Scenario
Summary
of
methodology/
sources
General
purpose
cleaner
Used
CEM
generic
scenario
with
default
parameters.
Removed
inhalation
exposure
scenario
because
no
vapor
pressure
information
was
available.
Product
assumed
to
not
be
volatile.

Laundry
detergent
Used
CEM
generic
scenario
with
default
parameters.
Removed
inhalation
exposure
scenario
because
no
vapor
pressure
information
was
available.
Product
assumed
to
not
be
volatile.

Cosmetics
Followed
same
procedure
as
described
above
for
EDTA.

Food
contact
surface
sanitizing
solutions
Followed
same
procedure
as
described
above
for
EDTA.

Reference:

U.
S.
EPA,
1999.
Exposure
Factors
Handbook
(
EFH).
Office
of
Research
and
Development,
Washington,
D.
C.
EPA/
600/
C­
99/
001.
3
Ethylenediaminetetraacetic
Acid
(
EDTA)
(
CAS
Reg.
No.
60­
00­
4)

Use
Scenario:
General
Purpose
Cleaner
CEM
Inputs
ID
Number:
EDTA,
1
Product:
EDTA
Chemical
Name:
None
Scenario:
General
Purpose
Cleaner
Population:
Adult
Molecular
Weight
(
g/
mole):
292.2
Vapor
Pressure
(
torr):
1e­
07
Weight
Fraction
­
Median
(
unitless):
0.05
Weight
Fraction
­
90%
(
unitless):
0.05
Inhalation
Inputs
Frequency
of
Use
(
events/
yr):
300
Years
of
Use:
57
Mass
of
Product
Used
per
Event
­
Median
(
g):
61.5
Mass
of
Product
Used
per
Event
­
90%
(
g):
123
Inhalation
Rate
During
Use
(
m3/
hr):
0.55
Duration
of
Use
­
Median
(
hours/
event):
0.667
Inhalation
Rate
After
Use
(
m3/
hr):
0.55
Duration
of
Use
­
90%
(
hours/
event):
1.42
Zone
1
Volume
(
m3):
20
Whole
House
Volume
(
m3):
369
Air
Exchange
Rate
(
air
exchanges/
hr):
0.45
Body
Weight
(
kg):
71.8
Activity
Patterns
User:
1111111221542467422744411
Start
Time:
7
Non­
User:
Room
of
Use:
2.
Kitchen
Hour:
0
6
12
18
Dermal
Inputs
Frequency
of
Use
­
Body
(
events/
yr):
300
SA/
BW
­
Body
(
cm2/
kg):
15.6
Amount
Retained
/
Absorbed
to
Skin
(
g/
cm2­
event):
3.6e­
05
Avg.
Time,
LADDpot,
LADCpot
(
days):
2.74e+
04
Avg.
Time,
ADRpot,
Cppot
(
days)
:
1.00e+
00
4
CEM
Inhalation
Exposure
Estimates
ID
Number:
EDTA,
1
Scenario:
General
Purpose
Cleaner
Population:
Adult
Inhalation
Rate
(
m3/
day):
0.55
Years
of
Use
(
years):
57
Body
Weight
(
kg):
71.8
Frequency
of
Use
(
events/
year):
300
Exposure
Units
Result
AT
(
days)

Chronic
Cancer
LADDpot
(
mg/
kg­
day)
8.90e­
05
2.74e+
04
LADCpot
(
mg/
m3)
4.84e­
04
2.74e+
04
Acute
ADRpot
(
mg/
kg­
day)
6.31e­
06
1.00e+
00
Cppot
(
mg/
m3)
7.30e­
05
1.00e+
00
LADD
­
Lifetime
Average
Daily
Dose
(
mg/
kg­
day)
LADC
­
Lifetime
Average
Daily
Concentration
(
mg/
m3)

ADR
­
Acute
Dose
Rate
(
mg/
kg­
day)
Cp
­
Peak
Concentration
(
mg/
m3)

Note:
75
years
=
2.738e+
04
days
pot
­
potential
dose
Note:
The
general
Agency
guidance
for
assessing
short­
term,
infrequent
events
(
for
most
chemicals,
an
exposure
of
less
than
24
hours
that
occurs
no
more
frequently
than
monthly)
is
to
treat
such
events
as
independent,
acute
exposures
rather
than
as
chronic
exposure.
Thus,
estimates
of
long­
term
average
exposure
like
ADD
or
ADC
may
not
be
appropriate
for
use
in
assessing
risks
associated
with
this
type
of
exposure
pattern.
(
Methods
for
Exposure­
Response
Analysis
for
Acute
Inhalation
Exposure
to
Chemicals
(
External
Review
Draft).
EPA/
600/
R­
98/
051.
April
1998
5
CEM
Dermal
Exposure
Estimates
ID
Number:
EDTA,
1
Scenario:
General
Purpose
Cleaner
Population:
Adult
Years
of
Use
(
years):
57
SA/
BW
Body
(
cm2/
kg):
15.6
Frequency
of
Use
(
events/
year):
300
Exposure
Units
Result
AT
(
days)

Chronic
Cancer
LADDpot
(
mg/
kg­
day)
1.75e­
02
2.74e+
04
Acute
ADRpot
(
mg/
kg­
day)
2.81e­
02
1.00e+
00
LADD
­
Lifetime
Average
Daily
Dose
(
mg/
kg­
day)

ADR
­
Acute
Dose
Rate
(
mg/
kg­
day)

Note:
75
years
=
2.738e+
04
days
pot
­
potential
dose
Note:
The
general
Agency
guidance
for
assessing
short­
term,
infrequent
events
(
for
most
chemicals,
an
exposure
of
less
than
24
hours
that
occurs
no
more
frequently
than
monthly)
is
to
treat
such
events
as
independent,
acute
exposures
rather
than
as
chronic
exposure.
Thus,
estimates
of
long­
term
average
exposure
like
ADD
or
ADC
may
not
be
appropriate
for
use
in
assessing
risks
associated
with
this
type
of
exposure
pattern.
(
Methods
for
Exposure­
Response
Analysis
for
Acute
Inhalation
Exposure
to
Chemicals
(
External
Review
Draft).
EPA/
600/
R­
98/
051.
April
1998
6
Ethylenediaminetetraacetic
Acid
(
EDTA)
(
CAS
Reg.
No.
60­
00­
4)

Use
Scenario:
Laundry
Detergent
CEM
Inputs
ID
Number:
EDTA,
2
Product:
EDTA
Chemical
Name:
None
Scenario:
Laundry
Detergent
Population:
Adult
Molecular
Weight
(
g/
mole):
292.2
Vapor
Pressure
(
torr):
1e­
07
Weight
Fraction
­
Median
(
unitless):
0.05
Weight
Fraction
­
90%
(
unitless):
0.05
Inhalation
Inputs
Frequency
of
Use
(
events/
yr):
312
Years
of
Use:
57
Mass
of
Product
Used
per
Event
­
Median
(
g):
200
Mass
of
Product
Used
per
Event
­
90%
(
g):
400
Inhalation
Rate
During
Use
(
m3/
hr):
0.55
Duration
of
Use
­
Median
(
hours/
event):
0.333
Inhalation
Rate
After
Use
(
m3/
hr):
0.55
Duration
of
Use
­
90%
(
hours/
event):
0.667
Zone
1
Volume
(
m3):
20
Whole
House
Volume
(
m3):
369
Air
Exchange
Rate
(
air
exchanges/
hr):
0.45
Body
Weight
(
kg):
71.8
Activity
Patterns
User:
1111111235542467422744411
Start
Time:
9
Non­
User:
Room
of
Use:
5.
Utility
Room
Hour:
0
6
12
18
Dermal
Inputs
Frequency
of
Use
­
Body
(
events/
yr):
52
SA/
BW
­
Body
(
cm2/
kg):
15.6
Amount
Retained
/
Absorbed
to
Skin
(
g/
cm2­
event):
1.13e­
05
Avg.
Time,
LADDpot,
LADCpot
(
days):
2.74e+
04
Avg.
Time,
ADRpot,
Cppot
(
days)
:
1.00e+
00
7
CEM
Inhalation
Exposure
Estimates
ID
Number:
EDTA,
2
Scenario:
Laundry
Detergent
(
Machine
Washing)
Population:
Adult
Inhalation
Rate
(
m3/
day):
0.55
Years
of
Use
(
years):
57
Body
Weight
(
kg):
71.8
Frequency
of
Use
(
events/
year):
312
Exposure
Units
Result
AT
(
days)

Chronic
Cancer
LADDpot
(
mg/
kg­
day)
8.23e­
08
2.74e+
04
LADCpot
(
mg/
m3)
4.47e­
07
2.74e+
04
Acute
ADRpot
(
mg/
kg­
day)
5.13e­
07
1.00e+
00
Cppot
(
mg/
m3)
7.16e­
05
1.00e+
00
LADD
­
Lifetime
Average
Daily
Dose
(
mg/
kg­
day)
LADC
­
Lifetime
Average
Daily
Concentration
(
mg/
m3)

ADR
­
Acute
Dose
Rate
(
mg/
kg­
day)
Cp
­
Peak
Concentration
(
mg/
m3)

Note:
75
years
=
2.738e+
04
days
pot
­
potential
dose
Note:
The
general
Agency
guidance
for
assessing
short­
term,
infrequent
events
(
for
most
chemicals,
an
exposure
of
less
than
24
hours
that
occurs
no
more
frequently
than
monthly)
is
to
treat
such
events
as
independent,
acute
exposures
rather
than
as
chronic
exposure.
Thus,
estimates
of
long­
term
average
exposure
like
ADD
or
ADC
may
not
be
appropriate
for
use
in
assessing
risks
associated
with
this
type
of
exposure
pattern.
(
Methods
for
Exposure­
Response
Analysis
for
Acute
Inhalation
Exposure
to
Chemicals
(
External
Review
Draft).
EPA/
600/
R­
98/
051.
April
1998
8
CEM
Dermal
Exposure
Estimates
ID
Number:
EDTA,
2
Scenario:
Laundry
Detergent
(
Hand
Washing)
Population:
Adult
Years
of
Use
(
years):
57
SA/
BW
Body
(
cm2/
kg):
15.6
Frequency
of
Use
(
events/
year):
52
Exposure
Units
Result
AT
(
days)

Chronic
Cancer
LADDpot
(
mg/
kg­
day)
9.54e­
04
2.74e+
04
Acute
ADRpot
(
mg/
kg­
day)
8.81e­
03
1.00e+
00
LADD
­
Lifetime
Average
Daily
Dose
(
mg/
kg­
day)

ADR
­
Acute
Dose
Rate
(
mg/
kg­
day)

Note:
75
years
=
2.738e+
04
days
pot
­
potential
dose
Note:
The
general
Agency
guidance
for
assessing
short­
term,
infrequent
events
(
for
most
chemicals,
an
exposure
of
less
than
24
hours
that
occurs
no
more
frequently
than
monthly)
is
to
treat
such
events
as
independent,
acute
exposures
rather
than
as
chronic
exposure.
Thus,
estimates
of
long­
term
average
exposure
like
ADD
or
ADC
may
not
be
appropriate
for
use
in
assessing
risks
associated
with
this
type
of
exposure
pattern.
(
Methods
for
Exposure­
Response
Analysis
for
Acute
Inhalation
Exposure
to
Chemicals
(
External
Review
Draft).
EPA/
600/
R­
98/
051.
April
1998
9
Ethylenediaminetetraacetic
Acid
(
EDTA)
(
CAS
Reg.
No.
60­
00­
4)

Use
Scenario:
Cosmetics
CEM
Inputs
ID
Number:
EDTA,
C,
1
Product:
Cosmetics
Chemical
Name:
Cosmetic
Scenario:
User
Defined
Population:
Adult
Molecular
Weight
(
g/
mole):
0
Weight
Fraction
­
Median
(
unitless):
0.05
Weight
Fraction
­
90%
(
unitless):
0.05
Inhalation
Inputs
There
are
no
Inhalation
inputs
for
this
scenario.

Activity
Patterns
There
are
no
Activity
Patterns
for
this
scenario.

Dermal
Inputs
Frequency
of
Use
­
Body
(
events/
yr):
365
SA/
BW
­
Body
(
cm2/
kg):
8.41
Amount
Retained/
Absorbed
to
Skin
(
g/
cm2­
event):
1.9e­
06
Avg.
Time,
LADD
(
days):
2.74e+
04
Avg.
Time,
ADR
(
days):
1.00e+
00
10
CEM
Dermal
Exposure
Estimates
ID
Number:
EDTA,
C,
1
Scenario:
User
Defined
Population:
Adult
Years
of
Use
(
years):
50
SA/
BW
Body
(
cm2/
kg):
8.41
Frequency
of
Use
(
events/
year):
365
Exposure
Units
Result
AT
(
days)

Chronic
Cancer
LADDpot
(
mg/
kg­
day)
5.33e­
04
2.74e+
04
Acute
ADRpot
(
mg/
kg­
day)
7.99e­
04
1.00e+
00
LADD
­
Lifetime
Average
Daily
Dose
(
mg/
kg­
day)

ADR
­
Acute
Potential
Dose
Rate
(
mg/
kg­
day)

Note:
75
years
=
2.738e+
04
days
pot
­
potential
dose
Note:
The
general
Agency
guidance
for
assessing
short­
term,
infrequent
events
(
for
most
chemicals,
an
exposure
of
less
than
24
hours
that
occurs
no
more
frequently
than
monthly)
is
to
treat
such
events
as
independent,
acute
exposures
rather
than
as
chronic
exposure.
Thus,
estimates
of
long­
term
average
exposure
like
ADD
or
ADC
may
not
be
appropriate
for
use
in
assessing
risks
associated
with
this
type
of
exposure
pattern.
(
Methods
for
Exposure­
Response
Analysis
for
Acute
Inhalation
Exposure
to
Chemicals
(
External
Review
Draft).
EPA/
600/
R­
98/
051.
April
1998
11
Ethylenediaminetetraacetic
Acid
(
EDTA)
(
CAS
Reg.
No.
60­
00­
4)

Use
Scenario:
Food
contact
surface
sanitizing
solutions
The
inhalation
and
dermal
exposure
estimates
for
food
contact
surface
sanitizing
solutions
would
be
the
same
as
those
for
general
purpose
cleaners.
However,
food
contact
surface
sanitizing
solutions
also
have
the
potential
exposure
pathway
of
ingestion.
Based
on
the
assumption
that
food
contact
surface
sanitizing
solutions
can
include
products
such
as
dish
washing
detergents,
the
following
method
was
used
to
estimate
exposure:

Potential
Dose
Rate
(
PDR)
=
DD
*
SA
*
WF
*
TF,
where:

DD
=
Deposition
of
product
on
Dishes
=
0.0018
mg/
cm2
(
MRI,
1979)
SA
=
Surface
Area
of
all
silverware,
china,
and
glass
used
by
a
consumer
for
3
meals
=
4000
cm2
(
FDA,
2003)
WF
=
Weight
Fraction
of
EDTA
in
product
=
0.05
TF
=
Transfer
Factor
=
assumed
to
be
100%
(
worst
case)

Based
on
these
inputs,
the
PDR
is
0.36
mg/
day.

Normalized
PDR
(
PDR
norm
)
=
PDR
/
BW,
where:

BW
=
Body
Weight
=
71.8
kg
(
EFH,
1999)

Based
on
this
body
weight,
the
PDR
norm
is
0.005
mg/
kg/
day.

Lifetime
Average
Daily
Dose
(
LADD)
=
PDR
norm
*
ED
*
EF
/
(
AT
*
365
days/
yr),
where:

ED
=
Exposure
Duration
=
52
years
(
EFH,
1999)
EF
=
Exposure
Frequency
=
365
events/
year
(
Versar,
1986)
AT
=
Averaging
Time
=
70
years
(
EFH,
1999)

Based
on
these
inputs,
the
LADD
is
3.7x10­
3
mg/
kg/
day.

References:

April,
2003.
http://
www.
cfsan.
fda.
gov/~
dms/
opa­
cg3a.
html.
Last
accessed
June
9,
2003.

MRI,
1979.
Chemical
technology
and
economics
in
environmental
perspective.
Task
IV­
Potential
worker
and
consumer
exposure
to
nitrilotriacetic
acid
(
NTA)
in
detergents.
Midwest
Research
Institute.
Washington,
D.
C.:
Environmental
Protection
Agency.
PB­
297
753.

Versar,
1986.
Standard
Scenarios
for
Estimating
Exposure
to
Chemical
Substances
During
Use
of
Consumer
Products.
Volume
1.
Washington,
D.
C.:
Office
of
Pesticides
and
Toxic
Substances,
U.
S.
Environmental
Protection
Agency.
EPA
68­
02­
3968.
12
13
Ethylenediaminetetraacetic
Acid,
Tetrasodium
Salt
(
CAS
Reg.
No.
64­
02­
8)

Use
Scenario:
General
Purpose
Cleaner
CEM
Inputs
ID
Number:
EDTA
Salt
Product:
Cleaner
Chemical
Name:
EDTA,
Tetrasodium
Salt
Scenario:
General
Purpose
Cleaner
Population:
Adult
Molecular
Weight
(
g/
mole):
380.2
Vapor
Pressure
(
torr):
Not
available
Weight
Fraction
­
Median
(
unitless):
0.05
Weight
Fraction
­
90%
(
unitless):
0.05
Inhalation
Inputs
Frequency
of
Use
(
events/
yr):
300
Years
of
Use:
57
Mass
of
Product
Used
per
Event
­
Median
(
g):
61.5
Mass
of
Product
Used
per
Event
­
90%
(
g):
123
Inhalation
Rate
During
Use
(
m3/
hr):
0.55
Duration
of
Use
­
Median
(
hours/
event):
0.667
Inhalation
Rate
After
Use
(
m3/
hr):
0.55
Duration
of
Use
­
90%
(
hours/
event):
1.42
Zone
1
Volume
(
m3):
20
Whole
House
Volume
(
m3):
369
Air
Exchange
Rate
(
air
exchanges/
hr):
0.45
Body
Weight
(
kg):
71.8
Activity
Patterns
User:
1111111221542467422744411
Start
Time:
7
Non­
User:
Room
of
Use:
2.
Kitchen
Hour:
0
6
12
18
Dermal
Inputs
Frequency
of
Use
­
Body
(
events/
yr):
300
SA/
BW
­
Body
(
cm2/
kg):
15.6
Amount
Retained
/
Absorbed
to
Skin
(
g/
cm2­
event):
3.6e­
05
Avg.
Time,
LADDpot,
LADCpot
(
days):
2.74e+
04
Avg.
Time,
ADRpot,
Cppot
(
days)
:
1.00e+
00
14
CEM
Dermal
Exposure
Estimates
ID
Number:
EDTA
Salt
Scenario:
General
Purpose
Cleaner
Population:
Adult
Years
of
Use
(
years):
57
SA/
BW
Body
(
cm2/
kg):
15.6
Frequency
of
Use
(
events/
year):
300
Exposure
Units
Result
AT
(
days)

Chronic
Cancer
LADDpot
(
mg/
kg­
day)
1.75e­
02
2.74e+
04
Acute
ADRpot
(
mg/
kg­
day)
2.81e­
02
1.00e+
00
LADD
­
Lifetime
Average
Daily
Dose
(
mg/
kg­
day)

ADR
­
Acute
Dose
Rate
(
mg/
kg­
day)

Note:
75
years
=
2.738e+
04
days
pot
­
potential
dose
Note:
The
general
Agency
guidance
for
assessing
short­
term,
infrequent
events
(
for
most
chemicals,
an
exposure
of
less
than
24
hours
that
occurs
no
more
frequently
than
monthly)
is
to
treat
such
events
as
independent,
acute
exposures
rather
than
as
chronic
exposure.
Thus,
estimates
of
long­
term
average
exposure
like
ADD
or
ADC
may
not
be
appropriate
for
use
in
assessing
risks
associated
with
this
type
of
exposure
pattern.
(
Methods
for
Exposure­
Response
Analysis
for
Acute
Inhalation
Exposure
to
Chemicals
(
External
Review
Draft).
EPA/
600/
R­
98/
051.
April
1998
15
Ethylenediaminetetraacetic
Acid,
Tetrasodium
Salt
(
CAS
Reg.
No.
64­
02­
8)

Use
Scenario:
Laundry
Detergent
CEM
Inputs
ID
Number:
EDTA
Salt
Product:
Detergent
Chemical
Name:
EDTA,
Tetrasodium
Salt
Scenario:
Laundry
Detergent
Population:
Adult
Molecular
Weight
(
g/
mole):
380.2
Vapor
Pressure
(
torr):
1e­
07
Weight
Fraction
­
Median
(
unitless):
0.05
Weight
Fraction
­
90%
(
unitless):
0.05
Inhalation
Inputs
Frequency
of
Use
(
events/
yr):
312
Years
of
Use:
57
Mass
of
Product
Used
per
Event
­
Median
(
g):
200
Mass
of
Product
Used
per
Event
­
90%
(
g):
400
Inhalation
Rate
During
Use
(
m3/
hr):
0.55
Duration
of
Use
­
Median
(
hours/
event):
0.333
Inhalation
Rate
After
Use
(
m3/
hr):
0.55
Duration
of
Use
­
90%
(
hours/
event):
0.667
Zone
1
Volume
(
m3):
20
Whole
House
Volume
(
m3):
369
Air
Exchange
Rate
(
air
exchanges/
hr):
0.45
Body
Weight
(
kg):
71.8
Activity
Patterns
User:
1111111235542467422744411
Start
Time:
9
Non­
User:
Room
of
Use:
5.
Utility
Room
Hour:
0
6
12
18
Dermal
Inputs
Frequency
of
Use
­
Body
(
events/
yr):
52
SA/
BW
­
Body
(
cm2/
kg):
15.6
Amount
Retained
/
Absorbed
to
Skin
(
g/
cm2­
event):
1.13e­
05
Avg.
Time,
LADDpot,
LADCpot
(
days):
2.74e+
04
Avg.
Time,
ADRpot,
Cppot
(
days)
:
1.00e+
00
16
CEM
Dermal
Exposure
Estimates
ID
Number:
EDTA
Salt
Scenario:
Laundry
Detergent
(
Hand
Washing)
Population:
Adult
Years
of
Use
(
years):
57
SA/
BW
Body
(
cm2/
kg):
15.6
Frequency
of
Use
(
events/
year):
52
Exposure
Units
Result
AT
(
days)

Chronic
Cancer
LADD
pot
(
mg/
kg­
day)
9.54e­
04
2.74e+
04
Acute
ADRpot
(
mg/
kg­
day)
8.81e­
03
1.00e+
00
LADD
­
Lifetime
Average
Daily
Dose
(
mg/
kg­
day)

ADR
­
Acute
Dose
Rate
(
mg/
kg­
day)

Note:
75
years
=
2.738e+
04
days
pot
­
potential
dose
Note:
The
general
Agency
guidance
for
assessing
short­
term,
infrequent
events
(
for
most
chemicals,
an
exposure
of
less
than
24
hours
that
occurs
no
more
frequently
than
monthly)
is
to
treat
such
events
as
independent,
acute
exposures
rather
than
as
chronic
exposure.
Thus,
estimates
of
long­
term
average
exposure
like
ADD
or
ADC
may
not
be
appropriate
for
use
in
assessing
risks
associated
with
this
type
of
exposure
pattern.
(
Methods
for
Exposure­
Response
Analysis
for
Acute
Inhalation
Exposure
to
Chemicals
(
External
Review
Draft).
EPA/
600/
R­
98/
051.
April
1998
17
Ethylenediaminetetraacetic
Acid
(
EDTA)
(
CAS
Reg.
No.
60­
00­
4)

Use
Scenario:
Cosmetics
CEM
Inputs
ID
Number:
EDTA,
C,
1
Salt
Product:
Cosmetics
Chemical
Name:
Cosmetic
Scenario:
User
Defined
Population:
Adult
Molecular
Weight
(
g/
mole):
0
Weight
Fraction
­
Median
(
unitless):
0.05
Weight
Fraction
­
90%
(
unitless):
0.05
Inhalation
Inputs
There
are
no
Inhalation
inputs
for
this
scenario.

Activity
Patterns
There
are
no
Activity
Patterns
for
this
scenario.

Dermal
Inputs
Frequency
of
Use
­
Body
(
events/
yr):
365
SA/
BW
­
Body
(
cm2/
kg):
8.41
Amount
Retained/
Absorbed
to
Skin
(
g/
cm2­
event):
1.9e­
06
Avg.
Time,
LADD
(
days):
2.74e+
04
Avg.
Time,
ADR
(
days):
1.00e+
00
18
CEM
Dermal
Exposure
Estimates
ID
Number:
EDTA,
C,
1
Salt
Scenario:
User
Defined
Population:
Adult
Years
of
Use
(
years):
50
SA/
BW
Body
(
cm2/
kg):
8.41
Frequency
of
Use
(
events/
year):
365
Exposure
Units
Result
AT
(
days)

Chronic
Cancer
LADDpot
(
mg/
kg­
day)
5.33e­
04
2.74e+
04
Acute
ADRpot
(
mg/
kg­
day)
7.99e­
04
1.00e+
00
LADD
­
Lifetime
Average
Daily
Dose
(
mg/
kg­
day)

ADR
­
Acute
Potential
Dose
Rate
(
mg/
kg­
day)

Note:
75
years
=
2.738e+
04
days
pot
­
potential
dose
Note:
The
general
Agency
guidance
for
assessing
short­
term,
infrequent
events
(
for
most
chemicals,
an
exposure
of
less
than
24
hours
that
occurs
no
more
frequently
than
monthly)
is
to
treat
such
events
as
independent,
acute
exposures
rather
than
as
chronic
exposure.
Thus,
estimates
of
long­
term
average
exposure
like
ADD
or
ADC
may
not
be
appropriate
for
use
in
assessing
risks
associated
with
this
type
of
exposure
pattern.
(
Methods
for
Exposure­
Response
Analysis
for
Acute
Inhalation
Exposure
to
Chemicals
(
External
Review
Draft).
EPA/
600/
R­
98/
051.
April
1998
19
Ethylenediaminetetraacetic
Acid,
Tetrasodium
Salt
(
CAS
Reg.
No.
64­
02­
8)

Use
Scenario:
Food
contact
surface
sanitizing
solutions
The
inhalation
and
dermal
exposure
estimates
for
food
contact
surface
sanitizing
solutions
would
be
the
same
as
those
for
general
purpose
cleaners.
However,
food
contact
surface
sanitizing
solutions
also
have
the
potential
exposure
pathway
of
ingestion.
Based
on
the
assumption
that
food
contact
surface
sanitizing
solutions
can
include
products
such
as
dish
washing
detergents,
the
same
method
used
for
EDTA
(
shown
on
page
11
of
this
report)
would
be
used
to
estimate
exposure
to
the
tetrasodium
salt.
All
of
the
inputs
are
the
same,
therefore,
the
results
remain
the
same.
See
page
11
for
calculations.

Potential
Dose
Rate
(
PDR)
=
0.36
mg/
day.

Normalized
PDR
(
PDR
norm
)
=
0.005
mg/
kg/
day.

Lifetime
Average
Daily
Dose
(
LADD)
=
3.7x10­
3
mg/
kg/
day.
