Cypermethrin/
zeta­
cypermethrin
Dietary
Exposure
Assessment
DP
Barcode:
D293419
PC
Code:
109702
&
129064
Page
1
of
34
UNITED
STATES
ENVIRONMENTAL
PROTECTION
AGENCY
WASHINGTON,
D.
C.
20460
OFFICE
OF
PREVENTION,
PESTICIDES
AND
TOXIC
SUBSTANCES
MEMORANDUM
DATE:
16­
NOV­
2005
SUBJECT:
Cypermethrin/
zeta­
Cypermethrin:
Phase
2
Acute
(
Probabilistic)
and
Chronic
Dietary
Exposure
Assessments
for
the
Reregistration
Eligibility
Decision.

PC
Code:
109702
&
129064
DP
Barcode:
D293419
REVIEWER:
William
H.
Donovan,
Ph.
D.,
Chemist
RRB3/
Health
Effects
Division
(
7509C)

THROUGH:
Danette
Drew,
Branch
Senior
Scientist
RRB3/
Health
Effects
Division
(
7509C)

TO:
Veronique
LaCapra,
CRM
Yan
Donovan,
CRM
Reregistration
Branch
II
Special
Review
and
Reregistration
Division
(
7508W)

Note:
Attached
is
a
revised
version
of
the
cypermethrin/
zeta­
cypermethrin
acute
and
chronic
dietary
exposure
assessments
conducted
in
support
of
the
RED.
The
present
memo
incorporates
error­
only
revisions
provided
by
the
registrant
following
review
of
the
phase
1
dietary
assessment
(
D293418,
W.
Donovan,
15­
SEP­
2003).
The
specific
changes
made
were
as
described
previously
(
D298690,
W.
Donovan
and
P.
Hurley,
05­
MAR­
2004).
Cypermethrin/
zeta­
cypermethrin
Dietary
Exposure
Assessment
DP
Barcode:
D293419
PC
Code:
109702
&
129064
Page
2
of
34
Executive
Summary
The
purpose
of
this
memorandum
is
to
report
the
results
of
a
dietary
exposure
analysis
for
cypermethrin
and
zeta­
cypermethrin.
Cypermethrin
and
zeta­
cypermethrin
uses
are
considered
together
in
this
analysis
because
zeta­
cypemethrin
is
an
enriched
isomer
of
cypermethrin
and
no
distinction
is
made
between
cypermethrin
and
zeta­
cypermethrin
by
the
analytical
enforcement
method.
Cypermethrin
is
a
combination
of
eight
stereoisomers
with
percentage
compositions
ranging
from
11­
14%.
Zeta­
cypermethrin
is
a
combination
of
the
same
8
isomers
with
the
4
insecticidally
less
active
ones
at
a
concentration
of
1­
2%
each.
The
remaining
4
isomers,
two
of
which
are
regarded
as
being
the
most
insecticidally
active,
are
present
at
a
concentration
of
24%
each.
In
this
analysis
the
acute
and
chronic
dietary
exposure
and
risk
estimates
resulting
from
food
intake
were
determined
for
the
general
U.
S.
population
and
various
population
subgroups.

Partially
refined
acute
(
probabilistic)
and
chronic
dietary
exposure
assessments
were
performed
in
order
to
determine
the
exposure
and
risk
estimates
which
result
from
the
use
of
cypermethrin
and
zeta­
cypermethrin
on
the
crops
listed
under
40
CFR
180.418.
Anticipated
residues
from
USDA
Pesticide
Data
Program
(
PDP)
monitoring
data,
field
trial
data,
empirical
processing
factors,
and
percent
crop
treated
estimates
were
used
where
appropriate.

The
most
recent
previous
DEEM
analysis
for
cypermethrin/
zeta­
cypermethrin
was
conducted
using
version
7.76
of
the
DEEM
software
together
with
1989­
1992
consumption
data
(
D284633,
M.
Doherty,
20­
AUG­
2002).
The
current
assessment
updates
the
prior
assessment
by
1)
taking
into
account
an
additional
10x
safety
factor
as
recommended
in
a
22­
JAN­
2003
HIARC
meeting,
2)
use
of
version
1.3
of
the
DEEM­
FCID
 
program
with
1994­
1998
consumption
data,
and
3)
incorporation
of
anticipated
residue
levels
and
percent
crop
treated
estimates.

Both
current
assessments,
acute
and
chronic,
yield
exposure
results
that
are
below
HED's
level
of
concern.
The
most
highly
exposed
subpopulation
for
chronic
toxicity
after
this
refinement
is
children
1­
2,
with
1.6%
of
the
cPAD.
The
most
highly
exposed
subpopulation
for
acute
toxicity
is
children
1­
2,
with
61%
of
the
aPAD
at
the
99.9th
percentile.
The
chronic
exposure
for
the
general
US
population
is
0.7%
of
the
cPAD.
The
acute
exposure
for
the
general
US
population
is
26%
of
the
aPAD
at
the
99.9th
percentile.

I.
Introduction
Dietary
risk
assessment
is
based
upon
the
toxicity
of
a
given
pesticide
and
the
dietary
exposure
to
that
pesticide.
For
acute
and
chronic
assessments,
the
risk
is
expressed
as
dietary
exposure
in
terms
of
a
percentage
of
a
maximum
acceptable
dose.
The
maximum
acceptable
doses
for
specified
subgroups
of
the
U.
S.
populations
are
the
"
population
adjusted
doses"
(
PADs),
defined
as
the
Reference
Dose
(
RfD)
divided
by
the
special
FQPA
Safety
Factor
for
each
specified
Cypermethrin/
zeta­
cypermethrin
Dietary
Exposure
Assessment
DP
Barcode:
D293419
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109702
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129064
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34
population
subgroup.
The
PAD
is
a
dose
which
HED
has
concluded
will
result
in
no
unreasonable
adverse
health
effects.
For
acute
and
non­
cancer
chronic
exposures,
HED
is
concerned
when
estimated
dietary
exposure
exceeds
100%
of
the
PAD.
References
which
discuss
the
acute
and
chronic
risk
assessments
in
more
detail
are
available
on
the
EPA/
pesticides
web
site:
"
Available
Information
on
Assessing
Exposure
from
Pesticides,
A
User's
Guide",
6/
21/
2000,
web
link:
http://
www.
epa.
gov/
fedrgstr/
EPA­
PEST/
2000/
July/
Day­
12/
6061.
pdf
;
or
see
SOP
99.6
(
8/
20/
99).

II.
Residue
Information
Cypermethrin/
zeta­
cypermethrin
Use:

Tolerances
are
established
for
residues
of
cypermethrin
per
se
in
or
on
a
variety
of
crops
as
listed
under
40
CFR
180.418(
a)(
1),
while
tolerances
for
zeta­
cypermethrin
per
se
are
listed
under
40
CFR
180.418(
a)(
2).
The
Metabolism
Assessment
Review
Committee
(
MARC)
determined
that
the
residue
of
concern
for
enforcement
and
dietary
risk
assessment
purposes
is
zeta­
cypermethrin
plus
the
four
inactive
R­
isomers
in
plants,
livestock,
and
drinking
water
(
D269584,
Y.
Donovan,
03­
NOV­
2000).
Also,
the
MARC
determined
that
the
residues
of
the
metabolite
dichlorovinyl
acid
(
DCVA)
(
cis
and
trans)
need
not
be
included
in
the
tolerance
expression
or
risk
assessment
for
cypermethrin
and
zeta­
cypermethrin.
In
addition
to
the
permanent
tolerances
listed
for
cypermethrin
and
zeta­
cypermethrin,
the
present
analyses
also
take
into
account
the
Section
18
uses
of
zeta­
cypermethrin
on
flax
and
mustard
seed,
although
mustard
seed
is
not
included
as
a
raw
agricultural
commodity
(
RAC)
in
DEEM­
FCID
 
.
Because
anticipated
residue
levels
are
utilized
for
most
of
the
crops
in
the
present
analysis,
any
reassessed
tolerance
levels
from
the
residue
chemistry
chapter
(
Residue
Chemistry
Chapter
of
the
RED,
D289422,
W.
Donovan,
25­
SEP­
2003)
are
not
relevant
to
the
current
analyses.
For
crops
registered
for
use
with
both
cypermethrin
and
zeta­
cypermethrin,
no
attempt
was
made
to
combine
residues
from
separate
treatments
because
of
label
restrictions
that
limit
the
maximum
seasonal
total
of
cypermethrin
plus
zeta­
cypermethrin
to
equal
the
maximum
seasonal
total
for
cypermethrin
use
alone.

Residue
Data
used
for
Acute
and
Chronic
Assessments:

HED
SOP
99.6
was
used
for
the
classification
of
food
forms
with
respect
to
the
level
of
blending
(
8/
20/
99).
The
appropriate
use
of
field
trial
and
PDP
data
in
the
DEEM
software
depends
in
part
on
the
classification
of
each
commodity
as
"
blended­
B,"
"
partially
blended­
PB,"
or
"
not
blended­
NB."
When
making
use
of
field
trial
data
in
a
refined
acute
analysis,
mean
residue
levels
(
with
½
LOD
for
non­
detectable
residues)
multiplied
by
BEAD's
likely
maximum
percent
crop
treated
(%
CT)
value
are
utilized
for
blended
commodities,
while
the
discrete
residue
levels
(
i.
e.
full
data
set)
incorporating
BEAD's
likely
maximum
%
CT
as
a
probability
of
encountering
the
treated
RAC
are
used
for
commodities
designated
partially
blended
or
not
blended.
When
making
use
of
PDP
data
in
a
refined
acute
analysis,
the
entire
distribution
of
monitoring
data
with
no
further
Cypermethrin/
zeta­
cypermethrin
Dietary
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DP
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adjustment
for
%
CT
is
used
for
blended
commodities,
while
the
entire
distribution
of
monitoring
data
incorporating
BEAD's
likely
maximum
%
CT
as
a
probability
of
encountering
the
treated
RAC
is
utilized
for
commodities
designated
partially
blended
or
not
blended,
provided
less
than
30
detectable
residue
levels
are
present
in
the
monitoring
data
for
not
blended
commodities.
If
30
or
more
detects
occur
in
the
monitoring
data,
then
the
"
decomposition"
method
is
recommended.

When
making
use
of
crop
field
trial
data
in
a
refined
chronic
analysis,
mean
residue
levels
(
with
½
LOD
for
non­
detectable
residues)
multiplied
by
BEAD's
likely
average
percent
crop
treated
(%
CT)
value
are
utilized
as
a
point
estimate
for
all
commodities.
When
making
use
of
PDP
data
in
a
refined
chronic
analysis,
an
average
residue
level
is
utilized
as
a
point
estimate
for
all
commodities
as
determined
from
the
following:
the
detectable
residue
levels,
non­
detectable
residues
(
½
LOD)
and
the
appropriate
number
of
zeros
as
determined
from
BEAD's
likely
average
%
CT
value.

The
current
assessments
made
use
of
the
following
USDA
Pesticide
Data
Program
(
PDP)
results
for
cypermethrin:
frozen
spinach,
fresh
tomato,
and
sweet
bell
pepper
[
1999];
and
lettuce,
broccoli,
and
green
beans
[
2001].
To
ensure
that
at
least
100
samples
were
available
for
each
crop,
the
2001
green
bean
data
were
combined
with
results
from
1996
and
1998;
and
the
2001
lettuce
data
were
combined
with
results
from
1994.
In
accord
with
HED
SOP
99.3
[
26­
MAR­
1999],
the
PDP
results
for
lettuce,
broccoli,
spinach
and
green
beans
were
translated
to
the
SOPrecommended
crops
since
the
use
patterns
were
similar
between
the
analyzed
and
translated
crops.
However,
in
the
case
of
crop
subgroup
6C
(
dry
beans),
the
PDP
results
for
green
beans
were
used
in
conjunction
with
a
dry
down
factor
of
9x
to
account
for
the
difference
in
dry
matter
content
between
green
bean
(
9.9%)
and
dry
beans
(
90%)
[
Commodity
Dry
Matter
Database,
B.
A.
Schneider
&
Y.­
S.
Ng,
2001].

For
crops
where
no
(
or
insufficient)
PDP
data
were
available
and
no
translations
were
possible
from
PDP
data,
crop
field
trial
data
were
used
for
the
analyses,
except
for
cottonseed
and
flax
oil
where
tolerance
level
residues
were
assumed.
Thus,
both
assessments
made
use
of
crop
field
trial
data
for
the
following
crops:
alfalfa,
field
corn,
sweet
corn,
green
onion,
nonbell
pepper,
rice,
sorghum,
sugarcane,
and
wheat
[
D206793,
J.
Stokes,
02­
MAY­
1996;
D257955,
W.
D
Cutchin
&
Y.
Donovan,
22­
MAY­
2001;
D222649,
Y.
Donovan,
10­
MAY­
2001;
D258805,
Y.
Donovan,
22­
MAY­
2001;
and
D268861,
Y.
Donovan,
19­
NOV­
2001].

For
the
acute
assessment,
residue
distribution
files
(
RDFs)
were
generated
using
PDP
detects,
zeros,
and
½
LODs,
incorporating
maximum
percent
crop
treated
data
(
BEAD
email
communication,
Alan
Halvorson,
4/
17/
03;
Attachment
1),
except
for
blended
commodities
where
no
%
CT
adjustment
was
made.
For
crops
listed
under
both
cypermethrin
and
zeta­
cypermethrin
[
cabbage,
cotton,
lettuce,
onions,
and
pecans],
the
higher
of
the
two
%
CT
values
was
selected
for
use
in
the
dietary
assessments.
The
RDFs
were
used
probabilistically
in
the
acute
assessment
and
Cypermethrin/
zeta­
cypermethrin
Dietary
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are
listed
in
Attachment
2
of
this
document.
For
the
chronic
assessment,
the
average
of
the
values
of
PDP
detects,
zeros,
and
½
LODs,
incorporating
average
percent
crop
treated
data
from
BEAD,
was
used
as
a
point
estimate.
A
summary
of
the
residue
data
used
for
the
acute
and
chronic
dietary
assessments
appears
in
Table
14
below.

Processing
factors
for
soybean
oil,
molasses,
sugar,
tomato
paste
and
puree,
and
wheat
flour,
germ,
and
bran
were
reported
in
previous
reviews
[
D257955,
Y.
Donovan,
22­
MAY­
2001;
D258805,
Y.
Donovan,
22­
MAY­
2001;
D268861,
Y.
Donovan,
19­
NOV­
2001].
These
processing
factors
were
used
in
both
the
acute
and
chronic
analyses
and
are
shown
in
Table
1.
The
following
DEEM­
default
processing
factors
were
retained
in
the
analyses:
beef,
meat,
dried
1.92;
onion,
dry
bulb,
dried
9.0;
tomato,
dried
14.3;
and
tomato,
juice
1.5.

Table
1.
Processing
Factors
used
in
DEEM
analysis.

Commodity
Processing
Factor
for
Cypermethrin/
zeta­
cypermethrin
Sugarcane,
molasses
0.41a
Sugarcane,
sugar
0.06a
Rice,
hulls
4.8b
Rice,
bran
0.6b
Soybean
meal
0.3c
Soybean
oil
0.5c
Tomato
paste
0.5c
Tomato
puree
0.33c
Wheat
flour
0.22c
Wheat
germ
0.44c
Wheat
bran
1.4c
a
D257955,
Y.
Donovan,
22­
MAY­
2001
b
D258805,
Y.
Donovan,
22­
MAY­
2001
c
D268861,
Y.
Donovan,
19­
NOV­
2001
Tolerance
levels
have
been
established
for
residues
of
cypermethrin
and
zeta­
cypermethrin
in/
on
livestock­
derived
commodities
from
cattle,
goat,
sheep,
horse,
swine,
and
poultry.
The
determination
of
anticipated
residue
levels
for
these
commodities
is
described
in
detail
below.
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zeta­
cypermethrin
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LIVESTOCK
COMMODITIES
Anticipated
residues
(
ARs)
were
calculated
for
livestock
commodities
using
the
residue
data
from
livestock
feeding
studies
in
conjunction
with
anticipated
dietary
burden
estimates
comprised
of
cypermethrin/
zeta­
cypermethrin
treated
feed
items
and
experimentally
determined
processing
factors,
where
appropriate.

Cattle
Table
3
presents
the
determination
of
the
acute
and
chronic
anticipated
dietary
burden
levels
for
beef
and
dairy
cattle,
based
on
a
reasonable
diet.
This
diet
includes
a
contribution
from
aspirated
grain
fractions,
the
magnitude
of
which
is
derived
in
Table
2.
Table
4
summarizes
the
measured
cypermethrin
residue
levels
found
in
cattle
tissues
following
dosing
at
the
indicated
levels
from
a
bovine
feeding
study.
Note
that
all
animals
in
the
study
were
fitted
with
ear
tags
containing
cypermethrin
(
except
for
the
control
cows).
Consequently,
the
measured
residue
levels
represent
exposure
to
cypermethrin
from
both
dietary
(
feed)
and
topical
(
ear
tag)
sources.
These
results
are
used
to
calculate
acute
anticipated
residues
in
cattle
fed
at
15.6
ppm,
as
shown
in
Table
5.
Feeding
levels
for
these
calculations
were
selected
which
were
close
to
the
dietary
burden
and
had
finite
residue
levels.
In
those
cases
where
no
detectable
residues
were
found
at
any
feeding
level,
a
value
of
½
LOD
was
used
for
AR
determination.
These
acute
anticipated
residues
were
then
used
to
construct
RDFs
as
per
guidance
in
"
Clarification
of
AR
calculations
for
meat/
milk
in
acute
assessments,"
prepared
by
David
Miller
on
06­
APR­
1999.
According
to
this
guidance,
RDFs
are
created
from
calculated
ARs
by
adding
zeroes
in
proportion
to
the
highest
percent
crop
treated
value
of
any
one
feed
item
used
to
determine
the
dietary
burden.
For
cypermethrin/
zetacypermethrin
this
value
is
8%
based
on
alfalfa.
The
resulting
RDFs
for
meat
products
are
provided
in
Attachment
2
to
this
document.

Table
2.
Determination
of
Aspirated
Grain
Fraction
(
AGF)
Residue
Level
Commodity
Max/
Avg
grain
residue
(
ppm)
a
Concentration
Factor
a
AGF
Residue
Levelb
%
in
Grain
Fractionc
Residue
(
ppm)
d
Wheat
0.12/
0.031
113
13.6/
3.5
30
4.1/
1.1
Sorghum
0.38/
0.23
13.7
5.2/
3.2
6
0.31/
0.19
Soybean
<
0.03/
0.015
110
3.3/
1.65
16
0.53/
0.26
Corn
<
0.01
NDc
NDc
46
0
Total
4.94/
1.55
a
From
D268861,
Y.
Donovan,
19­
NOV­
2001.
b
Max/
Avg
grain
residue
*
Concentration
Factor.
c
From
memo,
"
Aspirated
Grain
Fractions
(
Grain
Dust):
A
Tolerance
Perspective",
E.
Saito
and
E.
Zager,
07­
JUN­
1994.
Cypermethrin/
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cypermethrin
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d
AGF
Residue
Level
*
%
in
Grain
Fraction.
e
Not
Determined.

Table
3.
Acute
and
chronic
anticipated
dietary
burdens
of
cypermethrin
and
zeta­
cypermethrin
from
various
feed
commodities
for
beef
and
dairy
cattle.

Feed
Commodity
Maximum
residue
levela/
Average
residue
level
(
ppm)
%
Dry
Matter
Beef
&
Dairy
Cattle
%
of
Diet
Acute
Anticipated
Dietary
Burden/
Chronic
Anticipated
Dietary
Burden
(
ppm)
f
Soybean
meal
0.009b/
0.009b
92
15
0.0015/
0.0015
Alfalfa
hay
18.3c/
7.68c
89
25
5.14/
2.16
Corn,
sweet,
forage
11.7d/
3.34d
48
40
9.75/
2.78
Rice
grain
1.14e/
0.54e
88
10
0.13/
0.06
AGF
4.94/
1.55
85
10
0.58/
0.18
Total
for
diet
100
15.6/
5.18
a
Maximum
residue
level
nearly
the
same
as
highest
average
field
trial
(
HAFT)
value.
b
Determined
as
soybean
meal
processing
factor
(
0.3x)
*
maximum
or
HAFT
residue
level
from
17
soybean
field
trials
(<
0.03
ppm):
(
D268861,
Y.
Donovan,
19­
NOV­
2001).
c
Maximum
or
average
of
22
alfalfa
trials:
16
cypermethrin
+
6
zeta­
cypermethrin
(
D206793,
J.
Stokes,
02­
MAY­
1996).
Cypermethrin
residue
levels
were
divided
by
a
factor
of
two
to
account
for
use
rate
differences.
d
Maximum
or
average
of
20
sweet
corn
trials:
10
cypermethrin
+
10
zeta­
cypermethrin
(
D222649,
Y.
Donovan,
10­
MAY­
2001;
D221661,
J.
Stokes,
12­
MAR­
1996).
Cypermethrin
residue
levels
were
divided
by
a
factor
of
two
to
account
for
use
rate
differences.
e
Maximum
or
average
of
22
rice
field
trials:
(
D258805,
Y.
Donovan,
22­
MAY­
2001).
f
[
Residue
level/%
Dry
Matter]
*
%
of
Diet.

Table
4.
Range
of
cypermethrin
residues
(
ppm)
a
found
in
cow
milk
and
tissue
samples.

Dose
(
ppm)
Pectoral
Muscle
Adductor
Muscle
Peritoneal
Fat
Subcutaneous
Fat
Kidney
Liver
Whole
Milk
Milk
Cream
Ear
Tag
(
ET)
NDb
NDb
NDb­
0.017
(
0.011)
NDb
NDb
<
0.01
<
0.002b
NDb­
0.016
(
0.010)

5+
ET
ND­
0.013
(<
0.010)
<
0.010b
0.101,0.150
(
0.125)
0.063,0.088
(
0.076)
NDb­
0.012
(<
0.010)
<
0.01
0.009,0.018
(
0.013)
0.073­
0.103
(
0.086)

15+
ET
0.038,0.079
(
0.058)
0.014,0.041
(
0.028)
0.444,0.527
(
0.485)
0.315,0.462
(
0.388)
0.012,0.016
(
0.014)
<
0.01
0.044,0.047
(
0.045)
0.214,0.314
(
0.259)
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cypermethrin
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Table
4.
Range
of
cypermethrin
residues
(
ppm)
a
found
in
cow
milk
and
tissue
samples.

Dose
(
ppm)
Pectoral
Muscle
Adductor
Muscle
Peritoneal
Fat
Subcutaneous
Fat
Kidney
Liver
Whole
Milk
Milk
Cream
Ear
Tag
(
ET)
NDb
NDb
NDb­
0.017
(
0.011)
NDb
NDb
<
0.01
<
0.002b
NDb­
0.016
(
0.010)

Page
8
of
34
50+
ET
0.104,0.199
(
0.151)
0.028,0.041
(
0.034)
1.350,1.956
(
1.653)
0.737,0.993
(
0.865)
0.024,0.070
(
0.047)
<
0.01
0.183,0.235
(
0.209)
0.663,1.009
(
0.763)

Data
are
from
5/
24/
95
memo,
J.
Morales
&
MRID
432780­
02.
a
Average
residue
in
parentheses.
b
Nondetectable
(<
0.002
ppm
for
whole
milk
samples;
<
0.010
ppm
for
tissue
and
milk
cream
samples).

Table
5.
Acute
Anticipated
Residues
in
Cattle
(
Uncorrected
for
%
CT)

Tissue
Anticipated
Dietary
Burden
(
ADB)
(
ppm)
Measured
Residues
from
Table
4
Anticipated
Acute
Residues
in
Cattle
(
ppm)
b
Residues
in
Feed
(
ppm)
Residues
in
Tissue
(
ppm)

Muscle
15.6
15
0.079
0.082
Liver
15.6
50
0.005a
0.0016
Kidney
15.6
15
0.016
0.017
Fat
15.6
15
0.527
0.55
Milk
15.6
15
0.047
0.049
a
Determined
as
½
LOD.
b
[
ADB/
Residues
in
Feed]
*
Residues
in
Tissue
In
a
similar
manner,
the
data
in
Table
4
were
used
to
calculate
chronic
anticipated
residues
in
cattle
fed
at
4.7
ppm,
as
shown
in
Table
6.
Instead
of
constructing
RDFs
for
each
tissue
as
done
for
the
acute
analysis,
the
percent
crop
treated
estimate
was
incorporated
directly
into
the
AR
value
by
selecting
the
highest
value
among
the
average
percent
crop
treated
values
of
the
livestock
feed
items.
This
value
was
found
to
be
3%
as
estimated
for
rice.
Thus,
the
resulting
chronic
AR
values
for
each
tissue
were
used
directly
in
the
chronic
analysis
as
a
point
estimate.

Table
6.
Chronic
Anticipated
Residues
in
Cattle
Tissue
Anticipated
Dietary
Burden
(
ADB)
(
ppm)
Measured
Residues
from
Table
4
Highest
Average
%
CT
Estimate
of
Feed
Items
Anticipated
Chronic
Residues
in
Cattle
(
ppm)
b
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Residues
in
Feed
(
ppm)
Residues
in
Tissue
(
ppm)

Muscle
5.18
15
0.059
3
0.00061
Liver
5.18
50
0.005a
3
0.000016
Kidney
5.18
15
0.014
3
0.00015
Fat
5.18
5
0.126
3
0.0039
Milk
5.18
5
0.014
3
0.00044
a
Determined
as
½
LOD.
b
[
ADB/
Residues
in
Feed]
*
Residues
in
Tissue
*
%
CT
Poultry
&
Swine
Tables
7
and
8
present
the
determination
of
the
acute
and
chronic
anticipated
dietary
burden
levels,
respectively,
for
poultry
and
swine,
based
on
reasonable
diets.
Table
9
summarizes
the
measured
cypermethrin
residue
levels
found
in
poultry
tissues
following
dosing
at
the
indicated
levels
from
a
poultry
feeding
study.
These
results
are
used
to
calculate
acute
anticipated
residues
in
poultry
fed
at
1.0
ppm,
as
shown
in
Table
10.
The
feeding
levels
that
were
selected
for
these
calculations
were
ones
which
were
close
to
the
dietary
burden
and
had
finite
residue
levels.
In
those
cases
where
no
detectable
residues
were
found
at
any
feeding
level,
a
value
of
½
LOD
was
used
for
AR
determination.
These
acute
anticipated
residues
were
then
used
to
construct
RDFs
as
per
guidance
in
"
Clarification
of
AR
calculations
for
meat/
milk
in
acute
assessments,"
prepared
by
David
Miller
on
06­
APR­
1999.
For
cypermethrin/
zeta­
cypermethrin,
the
highest
percent
crop
treated
value
was
the
6%
value
from
rice.
The
resulting
RDFs
for
poultry
products
are
provided
in
Attachment
2
to
this
document.

Table
7.
Acute
anticipated
dietary
burden
of
cypermethrin/
zeta­
cypermethrin
for
poultry
and
swine
Feed
Commodity
Maximum
residue
(
ppm)
Poultry
Swine
%
Diet
Burden
(
ppm)
d
%
Diet
Burden
(
ppm)
d
Soybean
meal
0.009a
20
0.0018
20
0.0018
Rice
grain
1.14
30
0.34
40
0.46
Rice
bran
0.68b
20
0.14
15
0.10
Rice
hulls
5.5c
10
0.55
0
0
Corn,
field,
grain
0.010
20
0.002
15
0.0015
AGF
4.94
0
0
10
0.49
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Total
100
1.0
100
1.1
a
Determined
as
soybean
meal
processing
factor
(
0.3x)
*
maximum
residue
level
from
17
soybean
field
trials
(<
0.03
ppm):
(
D268861,
Y.
Donovan,
19­
NOV­
2001).
b
Determined
as
rice
bran
processing
factor
(
0.6x)
*
maximum
residue
level
from
22
rice
grain
field
trials
(
1.14
ppm):
(
D258805,
Y.
Donovan,
22­
MAY­
2001).
c
Determined
as
rice
hull
processing
factor
(
4.8x)
*
maximum
residue
level
from
22
rice
grain
field
trials
(
1.14
ppm):
(
D258805,
Y.
Donovan,
22­
MAY­
2001).
d
Maximum
residue
*
%
Diet.
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cypermethrin
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Table
8.
Chronic
anticipated
dietary
burden
of
cypermethrin/
zeta­
cypermethrin
for
poultry
and
swine
Feed
Commodity
Average
residue
(
ppm)
Poultry
Swine
%
Diet
Burden
(
ppm)
d
%
Diet
Burden
(
ppm)
d
Soybean
meal
0.009a
20
0.0018
20
0.0018
Rice
grain
0.54
30
0.16
40
0.22
Rice
bran
0.32b
20
0.064
15
0.048
Rice
hulls
2.6c
10
0.26
0
0
Corn,
field,
grain
0.010
20
0.002
15
0.0015
AGF
1.55
0
0
10
0.155
Total
100
0.49
100
0.42
a
Determined
as
soybean
meal
processing
factor
(
0.3x)
*
HAFT
residue
level
from
17
soybean
field
trials
(<
0.03
ppm):
(
D268861,
Y.
Donovan,
19­
NOV­
2001).
b
Determined
as
rice
bran
processing
factor
(
0.6x)
*
average
residue
level
from
22
rice
grain
field
trials
(
0.54
ppm):
(
D258805,
Y.
Donovan,
22­
MAY­
2001).
c
Determined
as
rice
hull
processing
factor
(
4.8x)
*
average
residue
level
from
22
rice
grain
field
trials
(
0.54
ppm):
(
D258805,
Y.
Donovan,
22­
MAY­
2001).
d
Average
residue
*
%
Diet.

Table
9.
Cypermethrin
levels
in
Poultry
Tissue
and
Eggs
Dose
(
ppm)
Range
of
Cypermethrin
Residues
(
parent
only)
in
Various
Tissues
and
Organs
(
ppm)
a
Muscle
Fat
Kidney
Liver
Egg
Yolk
Whole
Egg
2
NAb
NDc­
0.016
(<
0.010)
NAb
NAb
0.009­
0.010
(
0.009)
<
0.005c
6
NAb
0.040­
0.086
(
0.064)
NAb
NAb
0.029­
0.037
(
0.033)
0.007­
0.010
(
0.009)

20
<
0.010c
0.134­
0.187
(
0.164)
<
0.010c
<
0.010c
0.067­
0.100
(
0.079)
0.017­
0.035
(
0.026)

Data
are
from
5/
24/
95
memo,
J.
Morales
&
MRID
432780­
01.
a
Average
residue
in
parenthesis.
b
NA
­
not
analyzed.
c
ND
­
not
detectable
(<
0.005
ppm
for
egg
samples;
<
0.010
ppm
for
tissue
samples).
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cypermethrin
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Table
10.
Acute
Anticipated
Residues
in
Poultry
(
Uncorrected
for
%
CT)

Tissue
Anticipated
Dietary
Burden
(
ADB)
(
ppm)
Measured
Residues
in
Table
9
Anticipated
Acute
Residues
in
Poultryb
Residues
in
Feed
Residues
in
Tissue
Muscle
1.0
20
0.005a
0.00025
Liver
1.0
20
0.005a
0.00025
Kidney
1.0
20
0.005a
0.00025
Fat
1.0
2
0.016
0.0080
Egg
yolk
1.0
2
0.010
0.0050
Whole
egg
1.0
6
0.010
0.0017
a
Determined
as
½
LOD.
b
[
ADB/
Residues
in
Feed]
*
Residues
in
Tissue
In
a
similar
manner,
the
data
in
Table
9
were
used
to
calculate
chronic
anticipated
residues
in
poultry
fed
at
0.49
ppm,
as
shown
in
Table
11.
Instead
of
constructing
RDFs
for
each
tissue
as
done
for
the
acute
analysis,
the
percent
crop
treated
estimate
was
incorporated
directly
into
the
AR
value
by
selecting
the
highest
value
among
the
average
percent
crop
treated
values
of
the
livestock
feed
items.
For
cypermethrin/
zeta­
cypermethrin,
this
value
is
3%
based
on
rice.
Thus,
the
resulting
chronic
AR
values
for
each
poultry
tissue
were
used
directly
in
the
chronic
analysis
as
point
estimates.

Table
11.
Chronic
Anticipated
Residues
in
Poultry
Tissue
Anticipated
Dietary
Burden
(
ppm)
Measured
Residues
from
Table
9
Highest
Average
%
CT
Estimate
of
Feed
Items
Anticipated
Chronic
Residues
in
Poultryb
Residues
in
Feed
Residues
in
Tissue
Muscle
0.49
20
0.005a
3
0.0000037
Liver
0.49
20
0.005a
3
0.0000037
Kidney
0.49
20
0.005a
3
0.0000037
Fat
0.49
20
0.164
3
0.00012
Egg
yolk
0.49
2
0.009
3
0.000066
Whole
egg
0.49
6
0.009
3
0.000022
a
Determined
as
½
LOD.
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zeta­
cypermethrin
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b
[
ADB/
Residues
in
Feed]
*
Residues
in
Tissue
*
%
CT
For
swine,
the
same
general
approach
was
taken
for
determination
of
acute
and
chronic
AR
values.
Thus,
residue
levels
from
the
bovine
feeding
study
presented
in
Table
4
were
used
with
the
acute
and
chronic
anticipated
dietary
burden
values
of
1.1
and
0.42
ppm,
respectively.
This
process
gave
the
values
listed
in
Table
12
for
the
acute
scenario
and
these
values
were
used
to
construct
the
corresponding
pork
RDFs
listed
in
Attachment
2
assuming
a
maximum
percent
crop
treated
level
of
6%
based
on
rice.
For
the
chronic
scenario,
the
anticipated
residue
levels
for
swine
are
collected
in
Table
13,
and
include
the
highest
average
percent
crop
treated
value
of
the
feed
items
used
in
determination
of
the
dietary
burden
for
swine
of
3%
for
rice.
Thus,
the
individual
anticipated
chronic
residue
levels
for
each
swine
tissue
were
directly
included
in
the
chronic
dietary
exposure
analysis
as
point
estimates.

Table
12.
Acute
Anticipated
Residues
in
Swine
(
Uncorrected
for
%
CT)

Tissue
Anticipated
Dietary
Burden
(
ppm)
Measured
Residues
from
Table
4
Anticipated
Acute
Residues
in
Swineb
Residues
in
Feed
Residues
in
Tissue
Muscle
1.1
15
0.079
0.0058
Liver
1.1
50
0.005a
0.00011
Kidney
1.1
15
0.016
0.0012
Fat
1.1
50
1.956
0.043
a
Determined
as
½
LOD.
b
[
ADB/
Residues
in
Feed]
*
Residues
in
Tissue
Table
13.
Chronic
Anticipated
Residues
in
Swine
Tissue
Anticipated
Dietary
Burden
(
ppm)
Measured
Residues
from
Table
4
Highest
Average
%
CT
Estimate
of
Feed
Items
Anticipated
Chronic
Residues
in
Swineb
Residues
in
Feed
Residues
in
Tissue
Muscle
0.42
15
0.059
3
0.000050
Liver
0.42
50
0.005a
3
0.0000013
Kidney
0.42
15
0.014
3
0.000012
Fat
0.42
5
0.126
3
0.00032
a
Determined
as
½
LOD.
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b
[
ADB/
Residues
in
Feed]
*
Residues
in
Tissue
*
%
CT
Table
14
summarizes
all
of
the
residue
information
used
in
this
assessment.

Table
14.
Data
and
Residue
Estimates
Used
in
Dietary
Analyses
RAC/
Food
Forms1
Classification2
Data
Source
#
Samples/
#
Detects
LOD
(
ppm)
%
CT
(
avg/
max)
Anticipated
Residues
Acute
(
RDF3)
Chronic
Alfalfa,
seed
B
alfalfa
FT
12/
12
0.01
2/
8
0.0086
0.0022
Subgroup
4A:
spinach,
leafy
amaranth,
arugula,
garland
chrysanthemum,
garden
cress,
upland
cress,
dandelion
leaves,
endive,
parsley
leaves
PB
1999
PDP
frozen
spinach
519/
14
(
3
BQL)
4
0.070
2/
5:
spinach
100/
100:
others
cyperspinach.
rdf
0.053
0.014
0.053
Subgroup
4B
(
except
celery
and
fennel):
cardoon,
rhubarb,
Swiss
chard
NB/
PB
1999
PDP
frozen
spinach
519/
14
(
3
BQL)
4
0.070
100/
100
0.053
0.053
Subgroup
5A
(
Head):
Cabbage,
Chinese
cabbage
napa,
Brussels
sprouts,
head
lettuce,
radicchio
(
4A)
NB
1994
&
2001
PDP
lettuce
134/
2
0.042
26/
56:
lettuce
3/
7:
cabbage
100/
100:
others
cyperlettuce.
rdf
cypercabbage.
rdf
0.022
0.0064
0.0015
0.022
Subgroup
5A
(
Stem):
Broccoli/
babyfood,
cauliflower,
Chinese
broccoli,
Chinese
cabbage
bok
choy,
Chinese
mustard,
kohlrabi
NB
2001
PDP
broccoli
720/
0
0.035
6/
12:
broccoli
13/
20:
cauliflow
100/
100:
others
cyperbroccoli.
rdf
0.0035
0.0175
0.0010
0.0023
0.0175
Subgroup
5B:
broccoli
raab,
mustard
greens,
collards,
rape
greens
NB/
PB
1999
PDP
frozen
spinach
519/
14
(
3
BQL)
4
0.070
9/
12:
mg
&
collard
100/
100:
others
cypermusgreens.
rdf
0.053
0.021
0.053
Subgroups
6A
and
6B:
succulent
broad
bean,
succulent
cowpea
bean,
succulent
lima
bean,
succulent
pea,
succulent
edible
podded
pea,
succulent
pigeon
pea
PB
1996,
1998,
&
2001
PDP
green
beans
207/
0
0.028
100/
100
0.014
0.014
Subgroup
6C:
seeds:
black
bean,
broad
bean,
chickpea,
cowpea
bean,
great
northern
bean,
guar,
kidney
bean,
lentil,
lima
bean,
mung
bean,
navy
bean,
pink
bean,
pinto
bean,
pigeon
pea,
dry
pea
B
1996,
1998,
&
2001
PDP
green
beans
207/
0
0.028
100/
100
0.135
0.135
Beet,
sugar/
molasses,
babyfood
B
sugar
beet
FT
26/
0
0.01
100/
100
0.0050
0.0050
Cypermethrin/
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Table
14.
Data
and
Residue
Estimates
Used
in
Dietary
Analyses
RAC/
Food
Forms1
Classification2
Data
Source
#
Samples/
#
Detects
LOD
(
ppm)
%
CT
(
avg/
max)
Anticipated
Residues
Acute
(
RDF3)
Chronic
Page
15
of
34
Celery/
babyfood,
juice;
celtuce;
fennel,
Florence
NB/
PB
celery
FT
14/
14
0.050
1/
4
cypercelery.
rdf
0.017
Corn,
field/
flour,
meal,
bran,
starch,
syrup,
oil,
babyfood
B
field
corn
FT
23/
2
0.010
1/
1
0.000054
0.000054
Corn,
pop
B
field
corn
FT
23/
2
0.010
1/
1
0.000054
0.000054
Corn,
sweet/
babyfood
NB
sweet
corn
FT
20/
1
0.010
1/
2
cypersweetcorn.
rdf
0.00014
Cottonseed,
oil/
babyfood
B
Tolerance
level
NA
NA
5/
12
0.060
0.025
Eggplant
NB
1999
PDP
fresh
tomato
180/
0
0.025
100/
100
0.0125
0.0125
Flaxseed,
oil
B
Tolerance
level
NA
NA
100/
100
0.20
0.20
Garlic;
dried/
babyfood
NB/
B
dry
bulb
onion
FT
22/
0
0.010
13/
29
0.0015
0.00065
Kale
PB
1999
PDP
frozen
spinach
519/
14
(
3
BQL)
4
0.070
13/
20
cyperkale.
rdf
0.023
Lettuce,
leaf
PB
1994
&
2001
PDP
lettuce
134/
2
0.042
26/
56
cyperlettuce.
rdf
0.0064
Onion,
dry
bulb/
babyfood;
dried
NB/
B
dry
bulb
onion
FT
22/
0
0.010
15/
38
0.0019
0.00075
Onion,
green;
leek
PB/
NB
green
onion
FT
24/
24
0.010
15/
38
cypergreenonion.
rdf
0.098
Pecan
PB
Tolerance
level
NA
NA
9/
13
0.0065
0.0045
Pepper,
bell/
babyfood,
dried
NB
1999
PDP
sweet
bell
pepper
356/
0
0.070
100/
100
0.035
0.035
Pepper,
nonbell/
babyfood,
dried
NB
chili
pepper
FT
6/
3
0.030
100/
100
cyperpepper.
rdf
0.061
Rice/
white,
brown,
flour,
bran,
babyfood;
wild
rice
B
rice
FT
44/
44
0.020
3/
6
0.032
0.016
Shallot
B
green
onion
FT
24/
24
0.010
15/
38
0.25
0.098
Sorghum/
grain,
syrup
B
sorghum
FT
18/
18
0.010
1/
1
0.0025
0.0025
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Table
14.
Data
and
Residue
Estimates
Used
in
Dietary
Analyses
RAC/
Food
Forms1
Classification2
Data
Source
#
Samples/
#
Detects
LOD
(
ppm)
%
CT
(
avg/
max)
Anticipated
Residues
Acute
(
RDF3)
Chronic
Page
16
of
34
Soybean/
seed,
flour,
soy
milk,
oil,
babyfood
B
soybean
FT
34/
0
0.030
1/
1
0.00015
0.00015
Sugarcane/
sugar,
molasses,
babyfood
B
sugarcane
FT
15/
15
0.010
100/
100
0.18
0.18
Tomatillo;
Tomato,
juice
NB/
PB
1999
PDP
fresh
tomato
180/
0
0.025
1/
2
0.00025
0.000125
Tomato/
fresh
(
NB/
PB),
paste,
puree,
dried,
babyfood
B
1999
PDP
fresh
tomato
180/
0
0.025
1/
2
0.00025
0.000125
Turnip,
greens
PB
1999
PDP
frozen
spinach
519/
14
(
3
BQL)
4
0.070
4/
8
cyperturngreens.
rdf
0.020
Wheat/
grain,
flour,
germ,
bran,
babyfood
B
wheat
FT
32/
22
0.010
1/
1
0.00032
0.00032
Beef,
meat/
babyfood,
dried
NA
AR
NA
0.010
3/
8
cypermeat.
rdf
0.00061
Beef,
meat
byproduct/
babyfood
NA
AR
NA
0.010
3/
8
cyperkidney.
rdf
0.00015
Beef,
fat/
babyfood
NA
AR
NA
0.010
3/
8
cyperfat.
rdf
0.0039
Beef,
kidney
NA
AR
NA
0.010
3/
8
cyperkidney.
rdf
0.00015
Beef,
liver/
babyfood
NA
AR
NA
0.010
3/
8
cyperliver.
rdf
0.000016
Chicken,
meat/
babyfood
NA
AR
NA
0.010
3/
6
cyperpoultrymeat.
rdf
0.000004
Chicken,
liver
NA
AR
NA
0.010
3/
6
cyperpoultrymeat.
rdf
0.000004
Chicken,
meat
byproduct/
babyfood
NA
AR
NA
0.010
3/
6
cyperpoultrymeat.
rdf
0.000004
Chicken,
fat/
babyfood
NA
AR
NA
0.010
3/
6
cyperpoultryfat.
rdf
0.00012
Chicken,
skin/
babyfood
NA
AR
NA
0.010
3/
6
cyperpoultryfat.
rdf
0.00012
Egg,
whole/
babyfood
NA
AR
NA
0.005
3/
6
cypereggwhole.
rdf
0.000022
Egg,
white/
babyfood
NA
AR
NA
0.005
3/
6
cypereggwhole.
rdf
0.000022
Egg,
yolk/
babyfood
NA
AR
NA
0.005
3/
6
cypereggyolk.
rdf
0.000066
Goat
,
sheep
&
horse
Same
as
Beef
Milk,
fat/
nonfat
solids,
water,
sugar,
babyfood
NA
AR
NA
0.010
3/
8
cypermilk.
rdf
0.00044
Pork,
meat/
babyfood
NA
AR
NA
0.010
3/
6
cyperporkmeat.
rdf
0.000050
Pork,
skin
NA
AR
NA
0.010
3/
6
cyperporkfat.
rdf
0.00032
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Table
14.
Data
and
Residue
Estimates
Used
in
Dietary
Analyses
RAC/
Food
Forms1
Classification2
Data
Source
#
Samples/
#
Detects
LOD
(
ppm)
%
CT
(
avg/
max)
Anticipated
Residues
Acute
(
RDF3)
Chronic
Page
17
of
34
Pork,
meat
byproducts/
babyfood
NA
AR
NA
0.010
3/
6
cyperporkkidney.
rdf
0.000012
Pork,
fat/
babyfood
NA
AR
NA
0.010
3/
6
cyperporkfat.
rdf
0.00032
Pork,
kidney
NA
AR
NA
0.010
3/
6
cyperporkkidney.
rdf
0.000012
Pork,
liver
NA
AR
NA
0.010
3/
6
cyperporkliver.
rdf
0.000001
Poultry
and
turkey
Same
as
chicken
1
Crops
are
grouped
according
to
acceptable
data
translations
of
PDP
data
as
detailed
in
SOP
99.3.
2
Classification
of
blended
(
B),
partially
blended
(
PB),
not
blended
(
NB)
[
Change
in
Classification
of
Food
Forms
with
Respect
to
"
Not
Blended,"
"
Partially
Blended,"
and
"
Blended"
Status,
HED's
ChemSAC
memo,
8/
20/
1999].
3
See
Attachment
2
for
detailed
RDFs.
4
BQL
=
between
the
quantitation
limits
(
between
the
limit
of
detection
[
LOD]
and
the
limit
of
quantitation
[
LOQ].
PDP
BQL
reported
as
0.083
ppm.
½
BQL,
or
0.042
ppm,
is
used
in
the
dietary
assessment
for
these
3
out
of
14
detects.
The
remaining
11
detects
are
above
the
LOQ.
5
½
LOD
*
9
(
see
Residue
Information
discussion).

III.
DEEM­
FCID
 
Program
and
Consumption
Information
Cypermethrin
acute
and
chronic
dietary
exposure
assessments
were
conducted
using
the
Dietary
Exposure
Evaluation
Model
software
with
the
Food
Commodity
Intake
Database
(
DEEMFCID
 
,
Version
1.3).
This
software
incorporates
consumption
data
from
USDA's
Continuing
Surveys
of
Food
Intakes
by
Individuals
(
CSFII),
1994­
1996
and
1998.
The
1994­
96
and
1998
data
are
based
on
the
reported
consumption
of
more
than
20,000
individuals
over
two
nonconsecutive
survey
days.
Foods
"
as
consumed"
(
e.
g.,
apple
pie)
are
linked
to
EPA­
defined
food
commodities
(
e.
g.
apples,
peeled
fruit
­
cooked;
fresh
or
N/
S;
baked;
or
wheat
flour
­
cooked;
fresh
or
N/
S,
baked)
using
publicly
available
recipe
translation
files
developed
jointly
by
USDA/
ARS
and
EPA.
Consumption
data
are
averaged
for
the
entire
U.
S.
population
and
within
population
subgroups
for
chronic
exposure
assessment,
but
are
retained
as
individual
consumption
events
for
acute
exposure
assessment.

For
chronic
exposure
and
risk
assessment,
an
estimate
of
the
residue
level
in
each
food
or
foodform
(
e.
g.,
orange
or
orange
juice)
on
the
food
commodity
residue
list
is
multiplied
by
the
average
daily
consumption
estimate
for
that
food/
food
form.
The
resulting
residue
consumption
estimate
for
each
food/
food
form
is
summed
with
the
residue
consumption
estimates
for
all
other
food/
food
forms
on
the
commodity
residue
list
to
arrive
at
the
total
average
estimated
exposure.
Exposure
is
expressed
in
mg/
kg
body
weight/
day
and
as
a
percent
of
the
cPAD.
This
procedure
is
performed
for
each
population
subgroup.

For
acute
exposure
assessments,
individual
one­
day
food
consumption
data
are
used
on
an
individual­
by­
individual
basis.
The
reported
consumption
amounts
of
each
food
item
can
be
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multiplied
by
a
residue
point
estimate
and
summed
to
obtain
a
total
daily
pesticide
exposure
for
a
deterministic
exposure
assessment,
or
"
matched"
in
multiple
random
pairings
with
residue
values
and
then
summed
in
a
probabilistic
assessment.
The
resulting
distribution
of
exposures
is
expressed
as
a
percentage
of
the
aPAD
on
both
a
user
(
i.
e.,
those
who
reported
eating
relevant
commodities/
food
forms)
and
a
per­
capita
(
i.
e.,
those
who
reported
eating
the
relevant
commodities
as
well
as
those
who
did
not)
basis.
In
accordance
with
HED
policy,
per
capita
exposure
and
risk
are
reported
for
all
analyses.
However,
any
significant
differences
in
user
vs.
per
capita
exposure
and
risk
are
identified
and
noted
in
the
risk
assessment.

IV.
Toxicological
Information
The
HIARC
met
on
22­
JAN­
2003
to
reassess
FQPA
requirements
in
response
to
questions
posed
by
the
Natural
Resources
Defense
Council
(
NRDC)
as
they
pertain
to
cypermethrin.
HIARC
also
reviewed
the
previous
recommendation
for
a
developmental
neurotoxicity
study
in
rats
and
subsequent
need
for
a
data
base
factor
to
account
for
this
data
gap.
No
new
data
have
been
reviewed
and
no
changes
were
made
to
the
toxicology
endpoints
previously
selected
for
cypermethrin
and
zeta­
cypermethrin.
This
meeting
updated
the
previous
HIARC
report
dated
January
17,
2001
(
TXR
NO.
014445).
The
results
are
presented
in
a
memo
by
Pam
Hurley,
TXR
No.
0051578,
Cypermethrin
­
5th
Report
of
the
Hazard
Identification
Assessment
review
Committee,
dated
19­
FEB­
2003,
and
those
results
which
impact
the
dietary
exposure
assessment
are
summarized
in
Table
15.

Table
15.
Summary
of
Toxicological
Doses
and
Endpoints
for
Cypermethrin
for
Use
in
Dietary
Exposure
Assessment
Exposure
Scenario
Dose
Used
in
Risk
Assessment,
UF
Special
FQPA
SF
and
Level
of
Concern
for
Risk
Assessment
Study
and
Toxicological
Effects
Acute
Dietary
(
General
Population
including
infants
and
children)
NOAEL
=
10
mg
ai/
kg
UF
=
1000
Acute
RfD
=
0.01
mg/
kg/
day
FQPA
SF
=
1X
aPAD
=
acute
RfD
FQPA
SF
=
0.01
mg/
kg/
day
Acute
mammalian
neurotoxicity
study
Clinical
signs
of
neurotoxicity
and
changes
in
the
FOB
at
the
LOAEL
of
50
mg/
kg.

Chronic
Dietary
(
All
populations)
NOAEL
=
6
mg
ai/
kg/
day
UF
=
1000
Chronic
RfD
=
0.006
mg/
kg/
day
1X
cPAD
=
chronic
RfD
FQPA
SF
=
0.006
mg/
kg/
day
Chronic
feeding
study
­
dog
Clinical
signs
of
neurotoxicity
and
mortality
in
males,
and
decreased
body
weights
and
body
weight
gains
in
females
at
the
LOAEL
of
20.4
mg/
kg/
day.

Cancer
(
oral,
dermal,
inhalation)
Classification:
Category
C
(
possible
human
carcinogen)
No
quantitation
required.

UF
=
uncertainty
factor,
FQPA
SF
=
Special
FQPA
safety
factor,
NOAEL
=
no
observed
adverse
effect
level,
Cypermethrin/
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LOAEL
=
lowest
observed
adverse
effect
level,
PAD
=
population
adjusted
dose
(
a
=
acute,
c
=
chronic)
RfD
=
reference
dose,
MOE
=
margin
of
exposure,
LOC
=
level
of
concern,
NA
=
Not
Applicable
V.
Results/
Discussion
As
stated
above,
for
acute
and
chronic
assessments,
HED
is
concerned
when
dietary
risk
exceeds
100%
of
the
PAD.
The
DEEM­
FCID
 
analyses
estimate
the
dietary
exposure
of
the
U.
S.
population
and
various
population
subgroups.
The
results
reported
in
Tables
16­
18
are
for
the
general
U.
S.
Population,
all
infants
(<
1
year
old),
children
1­
2,
children
3­
5,
children
6­
12,
youth
13­
19,
females
13­
49,
adults
20­
49,
and
adults
50+
years.
The
results
for
the
other
population
subgroups
are
included
in
the
appendices.

Results
of
Acute
Dietary
Exposure
Analysis
Results
are
reported
at
the
99.9th
percentile
of
exposure
because
the
assessment
incorporated
percent
crop
treated
estimates
in
an
acute
probabilistic
analysis.

Table
16.
Results
of
Acute
Dietary
Exposure
Analysis
Population
Subgroup
aPAD
(
mg/
kg/
day)
95th
Percentile
99th
Percentile
99.9th
Percentile
Exposure
(
mg/
kg/
day)
%
aPAD
Exposure
(
mg/
kg/
day)
%
aPAD
Exposure
(
mg/
kg/
day)
%
aPAD
General
U.
S.
Population
0.01
0.000322
3.2
0.000856
8.6
0.002600
26
All
Infants
(<
1
year
old)
0.01
0.000431
4.3
0.000990
9.9
0.005644
56
Children
1­
2
years
old
0.01
0.001179
12
0.003141
31
0.006084
61
Children
3­
5
years
old
0.01
0.000896
9.0
0.001924
19
0.003687
37
Children
6­
12
years
old
0.01
0.000554
5.5
0.001249
12
0.002293
23
Youth
13­
19
years
old
0.01
0.000313
3.1
0.000705
7.1
0.001675
17
Adults
20­
49
years
old
0.01
0.000258
2.6
0.000536
5.4
0.001383
14
Females
13­
49
years
old
0.01
0.000243
2.4
0.000535
5.4
0.001415
14
Adults
50+
years
old
0.01
0.000226
2.3
0.000471
4.7
0.001397
14
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Results
of
Chronic
Dietary
Exposure
Analysis
Table
17.
Results
of
Chronic
Dietary
Exposure
Analysis
Population
Subgroup
cPAD
(
mg/
kg/
day)
Exposure
(
mg/
kg/
day)
%
cPAD
General
U.
S.
Population
0.006
0.000043
0.7
All
Infants
(<
1
year
old)
0.006
0.000049
0.8
Children
1­
2
years
old
0.006
0.000095
1.6
Children
3­
5
years
old
0.006
0.000083
1.4
Children
6­
12
years
old
0.006
0.000057
0.9
Youth
13­
19
years
old
0.006
0.000038
0.6
Adults
20­
49
years
old
0.006
0.000037
0.6
Females
13­
49
years
old
0.006
0.000035
0.6
Adults
50+
years
old
0.006
0.000034
0.6
VI.
Discussion
of
Uncertainties
The
residue
data
are
adequate
to
support
tolerances.
Much
of
the
zeta­
cypermethrin
residue
chemistry
database
was
recently
submitted.
The
studies
were
conducted
according
to
the
most
recent
guideline
recommendations.
Most
of
the
tolerance
levels
are
based
on
real
residues
that
were
determined
in
field
trial
studies
reflecting
the
maximum
use
rate
allowed
on
the
label
together
with
the
minimum
preharvest
interval
specified.

As
noted
in
the
Residue
Information
section,
PDP
data
were
used
in
these
analyses.
Specifically,
the
1999
results
for
frozen
spinach,
fresh
tomato,
and
sweet
bell
pepper
were
used
as
well
as
the
2001
results
for
lettuce,
broccoli,
and
green
beans.
Because
the
2001
data
for
lettuce
contained
less
than
100
samples,
these
data
were
combined
with
PDP
lettuce
data
from
1994.
For
the
same
reason,
the
2001
PDP
green
bean
data
were
combined
with
PDP
green
bean
data
from
1996
&
1998.
2001
PDP
celery
data
were
not
used
because
only
36
samples
were
analyzed;
thus,
for
celery,
field
trial
data
were
utilized.
The
PDP
data
were
translated
to
other
related
crops
as
allowed
by
SOP
99.3.
The
use
of
frozen
spinach
instead
of
fresh
spinach
may
introduce
some
uncertainty
to
the
analysis,
although
it
is
interesting
to
note
that
more
detectable
residues
were
found
in
this
commodity
than
any
other
in
the
PDP
cypermethrin
studies.

Experimentally­
determined
processing
factors
were
used
where
appropriate.
Otherwise,
DEEM
default
processing
factors
were
employed.
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Usage
data
were
available
for
many
crops
(
Attachment
2).
However,
for
crops
where
BEAD
did
not
provide
%
CT
estimates,
100%
crop
treated
was
assumed.
Thus,
should
this
information
become
available,
a
more
refined
analysis
with
correspondingly
lower
exposure
levels
may
be
expected.
Finally,
collection
and
use
of
market
basket
data
would
allow
for
a
more
refined
analysis
than
what
is
presented
in
this
memo.

VII.
Conclusions
Both
assessments,
acute
and
chronic,
yield
exposure
results
that
are
below
HED's
level
of
concern.
The
most
highly
exposed
subpopulation
for
chronic
toxicity
after
this
refinement
is
Children
1­
2
years
old,
with
1.6%
of
the
cPAD.
The
most
highly
exposed
subpopulation
for
acute
toxicity
is
Children
1­
2
years
old,
at
61%
of
the
aPAD
at
the
99.9th
percentile.
The
chronic
exposure
for
the
general
US
population
is
0.7%
of
the
cPAD.
The
acute
exposure
for
the
general
US
population
is
26%
of
the
aPAD
at
the
99.9th
percentile.

Table
18.
Summary
of
Dietary
Exposure
and
Risk
for
Cypermethrin
and
Zeta­
cypermethrin
Population
Subgroup
Acute
Dietary
Chronic
Dietary
Dietary
Exposure
(
mg/
kg/
day)
at
the
99.9th
percentile
%
aPAD
Dietary
Exposure
(
mg/
kg/
day)
%
cPAD
General
U.
S.
Population
0.002600
26
0.000050
0.7
All
Infants
(<
1
year
old)
0.005644
56
0.000051
0.8
Children
1­
2
years
old
0.006084
61
0.000107
1.6
Children
3­
5
years
old
0.003687
37
0.000094
1.4
Children
6­
12
years
old
0.002293
23
0.000065
0.9
Youth
13­
19
years
old
0.001675
17
0.000044
0.6
Adults
20­
49
years
old
0.001383
14
0.000044
0.6
Females
13­
49
years
old
0.001435
14
0.000041
0.6
Adults
50+
years
old
0.001397
14
0.000041
0.6
VIII.
List
of
Attachments
1.
BEAD
%
CT
information.
2.
Residue
Distribution
Files.
3.
Acute
Residue
Input
Data
for
DEEM­
FCID
 
Analysis.
4.
Acute
Residue
Analysis
for
Cypermethrin
&
zeta­
cypermethrin.
5.
Chronic
Residue
Input
Data
for
DEEM­
FCID
 
Analysis.
6.
Chronic
Residue
Analysis
for
Cypermethrin
&
zeta­
cypermethrin.
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Attachment
1.
BEAD
%
Crop
Treated
Information
(
as
attached
to
4/
17/
03
email
communication
from
A.
Halvorson
to
W.
Donovan)
PERCENT
CROP
TREATED
(
PCT)
ESTIMATES
FOR
EXISTING
USES
Alan
Halvorson,
BEAD/
EAB,
4/
17/
03
CYPERMETHRIN
­­

CROP
Avg
PCT
Max
PCT
Broccoli
6
12
Bulb
Crops(*)
16
25
Cabbage
3
7
Cauliflower
13
20
Celery
1
4
Cole
Crops(*)
3
9
Collards
9
12
Cotton
5
12
Garlic
13
29
Greens,
Mustard
8
12
Greens,
Turnip
4
8
Kale
13
20
Lettuce
26
56
Onions
15
38
Pecans
5
12
Spinach
2
5
ZETA­
CYPERMETHRIN
­­

CROP
Avg
PCT
Max
PCT
Bulb
Crops(*)
4
9
Cabbage
1
6
Carrots
1
3
Cole
Crops(*)
1
3
Corn,
Field
0.004
0.04
Cotton
4
10
Lettuce
17
41
Onions
13
18
Peanuts
0.2
0.7
Pecans
9
13
Sorghum
0.1
1
Soybeans
0.01
0.1
Sweet
Corn
0.5
2
Wheat,
Winter
0.001
0.01
(*)
These
estimates
based
on
data
ending
in
1997,
and
thus
may
be
somewhat
dated.

Sources:
­
USDA
1993­
2001
­
Proprietary
EPA
1995­
2001
Note:
%
CT
estimates
for
rice
(
avg
=
3%,
max=
6%)
and
alfalfa
(
avg=
2%,
max=
8%)
were
provided
by
A.
Halvorson
to
W.
Donovan
in
email
messages
dated
4/
30/
03
and
5/
7/
03,
respectively.
%
CT
estimates
for
tomato
(
avg=
1%,
max=
2%)
were
provided
by
A.
Halvorson
to
W.
Donovan
in
an
email
message
dated
2/
11/
04.
Cypermethrin/
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Attachment
2.
Residue
Distribution
Files
for
cypermethrin/
zeta­
cypermethrin.

Cyperbroccoli
TOTALNZ=
0
TOTALZ=
88
12,
0.0175
Cypercabbage,
7%
CT
TOTALNZ=
2
TOTALZ=
125
7,
0.021
0.058
0.10
Cypercelery
TOTALNZ=
14
TOTALZ=
336
1.03
1.19
2.09
2.30
1.24
0.95
0.97
0.94
1.61
2.37
2.70
3.85
1.11
0.95
Cypergreenonion
TOTALNZ=
24
TOTALZ=
39
0.40
0.57
0.18
0.19
0.14
0.15
0.13
0.13
0.21
0.14
0.19
0.19
0.34
0.72
0.43
0.22
0.12
0.22
0.32
0.30
2.7
2.7
2.5
2.5
Cyperkale
TOTALNZ=
14
TOTALZ=
415
90,
0.035
1.7
0.042
0.042
0.042
1.5
0.92
0.29
1.7
0.94
0.15
0.16
1.6
0.71
0.19
Cyperlettuce
TOTALNZ=
2
TOTALZ=
59
73,
0.021
0.058
0.10
Cypermustardgreens
TOTALNZ=
14
TOTALZ=
457
48,
0.035
1.7
0.042
0.042
0.042
1.5
0.92
0.29
1.7
0.94
0.15
0.16
1.6
0.71
0.19
Cyperpepper
TOTALNZ=
3
TOTALZ=
0
3,
0.015
0.03
0.10
0.19
Cyperspinach
TOTALNZ=
14
TOTALZ=
493
12,
0.035
1.7
0.042
0.042
0.042
1.5
0.92
0.29
1.7
0.94
0.15
0.16
1.6
0.71
0.19
Cypersweetcorn
TOTALNZ=
1
TOTALZ=
980
19,
0.005
0.04
Cyperturnipgreens
TOTALNZ=
14
TOTALZ=
477
28,
0.035
1.7
0.042
0.042
0.042
1.5
0.92
0.29
1.7
0.94
0.15
0.16
1.6
0.71
0.19
Cypermeat
TOTALNZ=
8
TOTALZ=
92
0.082
0.082
0.082
0.082
0.082
0.082
0.082
0.082
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Cyperkidney
TOTALNZ=
8
TOTALZ=
92
0.017
0.017
0.017
0.017
0.017
0.017
0.017
0.017
Cyperfat
TOTALNZ=
8
TOTALZ=
92
0.55
0.55
0.55
0.55
0.55
0.55
0.55
0.55
Cyperliver
TOTALNZ=
8
TOTALZ=
92
0.0016
0.0016
0.0016
0.0016
0.0016
0.0016
0.0016
0.0016
Cypereggyolk
TOTALNZ=
6
TOTALZ=
94
0.0050
0.0050
0.0050
0.0050
0.0050
0.0050
Cypereggwhole
TOTALNZ=
6
TOTALZ=
94
0.0017
0.0017
0.0017
0.0017
0.0017
0.0017
Cypermilk
TOTALNZ=
8
TOTALZ=
92
0.049
0.049
0.049
0.049
0.049
0.049
0.049
0.049
Cyperporkfat
TOTALNZ=
6
TOTALZ=
94
0.043
0.043
0.043
0.043
0.043
0.043
Cyperporkliver
TOTALNZ=
6
TOTALZ=
94
0.00011
0.00011
0.00011
0.00011
0.00011
0.00011
Cyperporkkidney
TOTALNZ=
6
TOTALZ=
94
0.0012
0.0012
0.0012
0.0012
0.0012
0.0012
Cyperporkmeat
TOTALNZ=
6
TOTALZ=
94
0.0058
0.0058
0.0058
0.0058
0.0058
0.0058
Cyperpoultryfat
TOTALNZ=
6
TOTALZ=
94
0.0080
0.0080
0.0080
0.0080
0.0080
0.0080
Cyperpoultrymeat
TOTALNZ=
6
TOTALZ=
94
0.00025
0.00025
0.00025
0.00025
0.00025
0.00025
Cypermethrin/
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Attachment
3.
DEEM
Residue
File
for
Acute
Assessment
Filename:
C:\
BackupFiles\
Cypermethrin\
109702a1.
R98
Chemical:
Cypermethrin
RfD(
Chronic):
.006
mg/
kg
bw/
day
NOEL(
Chronic):
6
mg/
kg
bw/
day
RfD(
Acute):
.01
mg/
kg
bw/
day
NOEL(
Acute):
10
mg/
kg
bw/
day
Date
created/
last
modified:
02­
20­
2004/
13:
40:
15/
8
Program
ver.
1.30
Comment:
Cypermethrin
&
Zeta­
cypermethrin
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
RDL
indices
and
parameters
for
Monte
Carlo
Analysis:
Index
Dist
Parameter
#
1
Param
#
2
Param
#
3
Comment
#
Code
­­­­­
­­­­
­­­­­­­­­­­­
­­­­­­­­
­­­­­­­­
­­­­­­­
1
6
cypermeat.
rdf
2
6
cyperkidney.
rdf
3
6
cyperfat.
rdf
4
6
cyperliver.
rdf
5
6
cyperbroccoli.
rdf
6
6
cypercabbage.
rdf
7
6
cypercelery.
rdf
8
6
cyperpoultrymeat.
rdf
9
6
cyperpoultryfat.
rdf
10
6
cypermusgreens.
rdf
11
6
cypersweetcorn.
rdf
12
6
cypereggwhole.
rdf
13
6
cypereggyolk.
rdf
14
6
cyperkale.
rdf
15
6
cypergreenonion.
rdf
16
6
cyperlettuce.
rdf
17
6
cypermilk.
rdf
18
6
cyperpepper.
rdf
19
6
cyperporkmeat.
rdf
20
6
cyperporkfat.
rdf
21
6
cyperporkkidney.
rdf
22
6
cyperporkliver.
rdf
23
6
cyperspinach.
rdf
24
6
cyperturngreens.
rdf
EPA
Crop
Commodity
Name
Def
Res
Adj.
Factors
RDL
Comment
Code
Grp
(
ppm)
#
1
#
2
Pntr
­­­­­­­­
­­­­
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­
­­­­­­
­­­­­­
­­­
­­­­­­­
18000020
18
Alfalfa,
seed
0.008600
1.000
1.000
04010050
4A
Amaranth,
leafy
0.053000
1.000
1.000
04010180
4A
Arugula
0.053000
1.000
1.000
06030300
6C
Bean,
black,
seed
0.130000
1.000
1.000
06020310
6B
Bean,
broad,
succulent
0.014000
1.000
1.000
06030320
6C
Bean,
broad,
seed
0.130000
1.000
1.000
06020330
6B
Bean,
cowpea,
succulent
0.014000
1.000
1.000
06030340
6C
Bean,
cowpea,
seed
0.130000
1.000
1.000
06030350
6C
Bean,
great
northern,
seed
0.130000
1.000
1.000
06030360
6C
Bean,
kidney,
seed
0.130000
1.000
1.000
06020370
6B
Bean,
lima,
succulent
0.014000
1.000
1.000
06030380
6C
Bean,
lima,
seed
0.130000
1.000
1.000
06030390
6C
Bean,
mung,
seed
0.130000
1.000
1.000
06030400
6C
Bean,
navy,
seed
0.130000
1.000
1.000
06030410
6C
Bean,
pink,
seed
0.130000
1.000
1.000
06030420
6C
Bean,
pinto,
seed
0.130000
1.000
1.000
06010430
6A
Bean,
snap,
succulent
0.014000
1.000
1.000
06010431
6A
Bean,
snap,
succulent­
babyfood
0.014000
1.000
1.000
21000440
M
Beef,
meat
1.000000
1.000
1.000
1
21000441
M
Beef,
meat­
babyfood
1.000000
1.000
1.000
1
21000450
M
Beef,
meat,
dried
1.000000
1.920
1.000
1
21000460
M
Beef,
meat
byproducts
1.000000
1.000
1.000
2
21000461
M
Beef,
meat
byproducts­
babyfood
1.000000
1.000
1.000
2
21000470
M
Beef,
fat
1.000000
1.000
1.000
3
21000471
M
Beef,
fat­
babyfood
1.000000
1.000
1.000
3
21000480
M
Beef,
kidney
1.000000
1.000
1.000
2
21000490
M
Beef,
liver
1.000000
1.000
1.000
4
21000491
M
Beef,
liver­
babyfood
1.000000
1.000
1.000
4
01010520
1A
Beet,
sugar
0.005000
1.000
1.000
01010521
1A
Beet,
sugar­
babyfood
0.005000
1.000
1.000
Cypermethrin/
zeta­
cypermethrin
Dietary
Exposure
Assessment
DP
Barcode:
D293419
PC
Code:
109702
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of
34
01010530
1A
Beet,
sugar,
molasses
0.005000
1.000
1.000
01010531
1A
Beet,
sugar,
molasses­
babyfood
0.005000
1.000
1.000
05010610
5A
Broccoli
1.000000
1.000
1.000
5
05010611
5A
Broccoli­
babyfood
1.000000
1.000
1.000
5
05010620
5A
Broccoli,
Chinese
0.017500
1.000
1.000
05020630
5B
Broccoli
raab
0.053000
1.000
1.000
05010640
5A
Brussels
sprouts
0.022000
1.000
1.000
05010690
5A
Cabbage
1.000000
1.000
1.000
6
05020700
5B
Cabbage,
Chinese,
bok
choy
0.017500
1.000
1.000
05010710
5A
Cabbage,
Chinese,
napa
0.022000
1.000
1.000
05010720
5A
Cabbage,
Chinese,
mustard
0.017500
1.000
1.000
04020760
4B
Cardoon
0.053000
1.000
1.000
05010830
5A
Cauliflower
0.003500
1.000
1.000
04020850
4B
Celery
1.000000
1.000
1.000
7
04020851
4B
Celery­
babyfood
1.000000
1.000
1.000
7
04020860
4B
Celery,
juice
1.000000
1.000
1.000
7
04020870
4B
Celtuce
1.000000
1.000
1.000
7
40000930
P
Chicken,
meat
1.000000
1.000
1.000
8
40000931
P
Chicken,
meat­
babyfood
1.000000
1.000
1.000
8
40000940
P
Chicken,
liver
1.000000
1.000
1.000
8
40000950
P
Chicken,
meat
byproducts
1.000000
1.000
1.000
8
40000951
P
Chicken,
meat
byproducts­
babyfoo
1.000000
1.000
1.000
8
40000960
P
Chicken,
fat
1.000000
1.000
1.000
9
40000961
P
Chicken,
fat­
babyfood
1.000000
1.000
1.000
9
40000970
P
Chicken,
skin
1.000000
1.000
1.000
9
40000971
P
Chicken,
skin­
babyfood
1.000000
1.000
1.000
9
06030980
6C
Chickpea,
seed
0.130000
1.000
1.000
06030981
6C
Chickpea,
seed­
babyfood
0.130000
1.000
1.000
06030990
6C
Chickpea,
flour
0.130000
1.000
1.000
04011040
4A
Chrysanthemum,
garland
0.053000
1.000
1.000
05021170
5B
Collards
1.000000
1.000
1.000
10
15001200
15
Corn,
field,
flour
0.000054
1.000
1.000
15001201
15
Corn,
field,
flour­
babyfood
0.000054
1.000
1.000
15001210
15
Corn,
field,
meal
0.000054
1.000
1.000
15001211
15
Corn,
field,
meal­
babyfood
0.000054
1.000
1.000
15001220
15
Corn,
field,
bran
0.000054
1.000
1.000
15001230
15
Corn,
field,
starch
0.000054
1.000
1.000
15001231
15
Corn,
field,
starch­
babyfood
0.000054
1.000
1.000
15001240
15
Corn,
field,
syrup
0.000054
1.000
1.000
15001241
15
Corn,
field,
syrup­
babyfood
0.000054
1.000
1.000
15001250
15
Corn,
field,
oil
0.000054
1.000
1.000
15001251
15
Corn,
field,
oil­
babyfood
0.000054
1.000
1.000
15001260
15
Corn,
pop
0.000054
1.000
1.000
15001270
15
Corn,
sweet
1.000000
1.000
1.000
11
15001271
15
Corn,
sweet­
babyfood
1.000000
1.000
1.000
11
95001280
O
Cottonseed,
oil
0.060000
1.000
1.000
95001281
O
Cottonseed,
oil­
babyfood
0.060000
1.000
1.000
04011330
4A
Cress,
garden
0.053000
1.000
1.000
04011340
4A
Cress,
upland
0.053000
1.000
1.000
04011380
4A
Dandelion,
leaves
0.053000
1.000
1.000
70001450
P
Egg,
whole
1.000000
1.000
1.000
12
70001451
P
Egg,
whole­
babyfood
1.000000
1.000
1.000
12
70001460
P
Egg,
white
1.000000
1.000
1.000
12
70001461
P
Egg,
white
(
solids)­
babyfood
1.000000
1.000
1.000
12
70001470
P
Egg,
yolk
1.000000
1.000
1.000
13
70001471
P
Egg,
yolk­
babyfood
1.000000
1.000
1.000
13
08001480
8
Eggplant
0.012500
1.000
1.000
04011500
4A
Endive
0.053000
1.000
1.000
04021520
4B
Fennel,
Florence
1.000000
1.000
1.000
7
20001630
20
Flaxseed,
oil
0.200000
1.000
1.000
03001640
3
Garlic
0.001500
1.000
1.000
03001650
3
Garlic,
dried
0.001500
1.000
1.000
03001651
3
Garlic,
dried­
babyfood
0.001500
1.000
1.000
23001690
M
Goat,
meat
1.000000
1.000
1.000
1
23001700
M
Goat,
meat
byproducts
1.000000
1.000
1.000
2
23001710
M
Goat,
fat
1.000000
1.000
1.000
3
23001720
M
Goat,
kidney
1.000000
1.000
1.000
2
23001730
M
Goat,
liver
1.000000
1.000
1.000
4
06031820
6C
Guar,
seed
0.130000
1.000
1.000
06031821
6C
Guar,
seed­
babyfood
0.130000
1.000
1.000
24001890
M
Horse,
meat
1.000000
1.000
1.000
1
05021940
5B
Kale
1.000000
1.000
1.000
14
Cypermethrin/
zeta­
cypermethrin
Dietary
Exposure
Assessment
DP
Barcode:
D293419
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Code:
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34
05011960
5A
Kohlrabi
0.017500
1.000
1.000
03001980
3
Leek
1.000000
1.000
1.000
15
06032030
6C
Lentil,
seed
0.130000
1.000
1.000
04012040
4A
Lettuce,
head
1.000000
1.000
1.000
16
04012050
4A
Lettuce,
leaf
1.000000
1.000
1.000
16
27002220
D
Milk,
fat
1.000000
1.000
1.000
17
27002221
D
Milk,
fat
­
baby
food/
infant
for
1.000000
1.000
1.000
17
27012230
D
Milk,
nonfat
solids
1.000000
1.000
1.000
17
27012231
D
Milk,
nonfat
solids­
baby
food/
in
1.000000
1.000
1.000
17
27022240
D
Milk,
water
1.000000
1.000
1.000
17
27022241
D
Milk,
water­
babyfood/
infant
form
1.000000
1.000
1.000
17
27032251
D
Milk,
sugar
(
lactose)­
baby
food/
1.000000
1.000
1.000
17
05022290
5B
Mustard
greens
1.000000
1.000
1.000
10
03002370
3
Onion,
dry
bulb
0.001900
1.000
1.000
03002371
3
Onion,
dry
bulb­
babyfood
0.001900
1.000
1.000
03002380
3
Onion,
dry
bulb,
dried
0.001900
9.000
1.000
03002381
3
Onion,
dry
bulb,
dried­
babyfood
0.001900
9.000
1.000
03002390
3
Onion,
green
1.000000
1.000
1.000
15
04012480
4A
Parsley,
leaves
0.053000
1.000
1.000
06022550
6B
Pea,
succulent
0.014000
1.000
1.000
06022551
6B
Pea,
succulent­
babyfood
0.014000
1.000
1.000
06032560
6C
Pea,
dry
0.130000
1.000
1.000
06032561
6C
Pea,
dry­
babyfood
0.130000
1.000
1.000
06012570
6A
Pea,
edible
podded,
succulent
0.014000
1.000
1.000
06032580
6C
Pea,
pigeon,
seed
0.130000
1.000
1.000
06022590
6B
Pea,
pigeon,
succulent
0.014000
1.000
1.000
14002690
14
Pecan
0.006500
1.000
1.000
08002700
8
Pepper,
bell
0.035000
1.000
1.000
08002701
8
Pepper,
bell­
babyfood
0.035000
1.000
1.000
08002710
8
Pepper,
bell,
dried
0.035000
1.000
1.000
08002711
8
Pepper,
bell,
dried­
babyfood
0.035000
1.000
1.000
08002720
8
Pepper,
nonbell
1.000000
1.000
1.000
18
08002721
8
Pepper,
nonbell­
babyfood
1.000000
1.000
1.000
18
08002730
8
Pepper,
nonbell,
dried
1.000000
1.000
1.000
18
25002900
M
Pork,
meat
1.000000
1.000
1.000
19
25002901
M
Pork,
meat­
babyfood
1.000000
1.000
1.000
19
25002910
M
Pork,
skin
1.000000
1.000
1.000
20
25002920
M
Pork,
meat
byproducts
1.000000
1.000
1.000
21
25002921
M
Pork,
meat
byproducts­
babyfood
1.000000
1.000
1.000
21
25002930
M
Pork,
fat
1.000000
1.000
1.000
20
25002931
M
Pork,
fat­
babyfood
1.000000
1.000
1.000
20
25002940
M
Pork,
kidney
1.000000
1.000
1.000
21
25002950
M
Pork,
liver
1.000000
1.000
1.000
22
60003010
P
Poultry,
other,
meat
1.000000
1.000
1.000
8
60003020
P
Poultry,
other,
liver
1.000000
1.000
1.000
8
60003030
P
Poultry,
other,
meat
byproducts
1.000000
1.000
1.000
8
60003040
P
Poultry,
other,
fat
1.000000
1.000
1.000
9
60003050
P
Poultry,
other,
skin
1.000000
1.000
1.000
9
04013130
4A
Radicchio
0.022000
1.000
1.000
05023180
5B
Rape
greens
0.053000
1.000
1.000
04023220
4B
Rhubarb
0.053000
1.000
1.000
15003230
15
Rice,
white
0.032000
1.000
1.000
15003231
15
Rice,
white­
babyfood
0.032000
1.000
1.000
15003240
15
Rice,
brown
0.032000
1.000
1.000
15003241
15
Rice,
brown­
babyfood
0.032000
1.000
1.000
15003250
15
Rice,
flour
0.032000
1.000
1.000
15003251
15
Rice,
flour­
babyfood
0.032000
1.000
1.000
15003260
15
Rice,
bran
0.032000
0.600
1.000
15003261
15
Rice,
bran­
babyfood
0.032000
0.600
1.000
03003380
3
Shallot
0.250000
1.000
1.000
26003390
M
Sheep,
meat
1.000000
1.000
1.000
1
26003391
M
Sheep,
meat­
babyfood
1.000000
1.000
1.000
1
26003400
M
Sheep,
meat
byproducts
1.000000
1.000
1.000
2
26003410
M
Sheep,
fat
1.000000
1.000
1.000
3
26003411
M
Sheep,
fat­
babyfood
1.000000
1.000
1.000
3
26003420
M
Sheep,
kidney
1.000000
1.000
1.000
3
26003430
M
Sheep,
liver
1.000000
1.000
1.000
2
15003440
15
Sorghum,
grain
0.002500
1.000
1.000
15003450
15
Sorghum,
syrup
0.002500
1.000
1.000
06003470
6
Soybean,
seed
0.000150
1.000
1.000
06003480
6
Soybean,
flour
0.000150
1.000
1.000
06003481
6
Soybean,
flour­
babyfood
0.000150
1.000
1.000
Cypermethrin/
zeta­
cypermethrin
Dietary
Exposure
Assessment
DP
Barcode:
D293419
PC
Code:
109702
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129064
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28
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34
06003490
6
Soybean,
soy
milk
0.000150
1.000
1.000
06003491
6
Soybean,
soy
milk­
babyfood
or
in
0.000150
1.000
1.000
06003500
6
Soybean,
oil
0.000150
0.500
1.000
06003501
6
Soybean,
oil­
babyfood
0.000150
0.500
1.000
04013550
4A
Spinach
1.000000
1.000
1.000
23
04013551
4A
Spinach­
babyfood
1.000000
1.000
1.000
23
95003620
O
Sugarcane,
sugar
0.180000
0.060
1.000
95003621
O
Sugarcane,
sugar­
babyfood
0.180000
0.060
1.000
95003630
O
Sugarcane,
molasses
0.180000
0.410
1.000
95003631
O
Sugarcane,
molasses­
babyfood
0.180000
0.410
1.000
04023670
4B
Swiss
chard
0.053000
1.000
1.000
08003740
8
Tomatillo
0.000250
1.000
1.000
08003750
8
Tomato
0.000250
1.000
1.000
08003751
8
Tomato­
babyfood
0.000250
1.000
1.000
08003760
8
Tomato,
paste
0.000250
0.500
1.000
08003761
8
Tomato,
paste­
babyfood
0.000250
0.500
1.000
08003770
8
Tomato,
puree
0.000250
0.330
1.000
08003771
8
Tomato,
puree­
babyfood
0.000250
0.330
1.000
08003780
8
Tomato,
dried
0.000250
14.300
1.000
08003781
8
Tomato,
dried­
babyfood
0.000250
14.300
1.000
08003790
8
Tomato,
juice
0.000250
1.500
1.000
50003820
P
Turkey,
meat
1.000000
1.000
1.000
8
50003821
P
Turkey,
meat­
babyfood
1.000000
1.000
1.000
8
50003830
P
Turkey,
liver
1.000000
1.000
1.000
8
50003831
P
Turkey,
liver­
babyfood
1.000000
1.000
1.000
8
50003840
P
Turkey,
meat
byproducts
1.000000
1.000
1.000
8
50003841
P
Turkey,
meat
byproducts­
babyfood
1.000000
1.000
1.000
8
50003850
P
Turkey,
fat
1.000000
1.000
1.000
9
50003851
P
Turkey,
fat­
babyfood
1.000000
1.000
1.000
9
50003860
P
Turkey,
skin
1.000000
1.000
1.000
9
50003861
P
Turkey,
skin­
babyfood
1.000000
1.000
1.000
9
05023890
5B
Turnip,
greens
1.000000
1.000
1.000
24
15004010
15
Wheat,
grain
0.000320
1.000
1.000
15004011
15
Wheat,
grain­
babyfood
0.000320
1.000
1.000
15004020
15
Wheat,
flour
0.000320
0.220
1.000
15004021
15
Wheat,
flour­
babyfood
0.000320
0.220
1.000
15004030
15
Wheat,
germ
0.000320
0.440
1.000
15004040
15
Wheat,
bran
0.000320
1.400
1.000
15004050
15
Wild
rice
0.032000
1.000
1.000
Cypermethrin/
zeta­
cypermethrin
Dietary
Exposure
Assessment
DP
Barcode:
D293419
PC
Code:
109702
&
129064
Page
29
of
34
Attachment
4.
Acute
Results
U.
S.
Environmental
Protection
Agency
Ver.
1.33
DEEM­
FCID
ACUTE
Analysis
for
CYPERMETHRIN
(
1994­
98
data)
Residue
file:
109702a1.
R98
Adjustment
factor
#
2
NOT
used.
Analysis
Date:
02­
27­
2004/
14:
25:
04
Residue
file
dated:
02­
20­
2004/
13:
40:
15/
8
Daily
totals
for
food
and
foodform
consumption
used.
MC
iterations
=
1000
MC
list
in
residue
file
MC
seed
=
9
Run
Comment:
"
Cypermethrin
&
Zeta­
cypermethrin:
updated
ARs"
===============================================================================

Summary
calculations
(
per
capita):

95th
Percentile
99th
Percentile
99.9th
Percentile
Exposure
%
aRfD
Exposure
%
aRfD
Exposure
%
aRfD
­­­­­­­­­­
­­­­­­­­
­­­­­­­­­­
­­­­­­­­
­­­­­­­­­­
­­­­­­­­
U.
S.
Population:
0.000322
3.22
0.000856
8.56
0.002600
26.00
All
infants:
0.000431
4.31
0.000990
9.90
0.005644
56.44
Children
1­
2
yrs:
0.001179
11.79
0.003141
31.41
0.006084
60.84
Children
3­
5
yrs:
0.000896
8.96
0.001924
19.24
0.003687
36.87
Children
6­
12
yrs:
0.000554
5.54
0.001249
12.49
0.002293
22.93
Youth
13­
19
yrs:
0.000313
3.13
0.000705
7.05
0.001675
16.75
Adults
20­
49
yrs:
0.000258
2.58
0.000536
5.36
0.001383
13.83
Adults
50+
yrs:
0.000226
2.26
0.000471
4.71
0.001397
13.97
Females
13­
49
yrs:
0.000243
2.43
0.000535
5.35
0.001415
14.15
Cypermethrin/
zeta­
cypermethrin
Dietary
Exposure
Assessment
DP
Barcode:
D293419
PC
Code:
109702
&
129064
Page
30
of
34
Attachment
5.
DEEM
Residue
File
for
Chronic
Assessment
Filename:
C:\
BackupFiles\
Cypermethrin\
109702c1.
R98
Chemical:
Cypermethrin
RfD(
Chronic):
.006
mg/
kg
bw/
day
NOEL(
Chronic):
6
mg/
kg
bw/
day
RfD(
Acute):
.01
mg/
kg
bw/
day
NOEL(
Acute):
10
mg/
kg
bw/
day
Date
created/
last
modified:
02­
27­
2004/
14:
01:
49/
8
Program
ver.
1.30
Comment:
Cypermethrin
&
Zeta­
cypermethrin
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
EPA
Crop
Def
Res
Adj.
Factors
Comment
Code
Grp
Commodity
Name
(
ppm)
#
1
#
2
­­­­­­­­
­­­­
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­
­­­­­­
­­­­­­
­­­­­­­
18000020
18
Alfalfa,
seed
0.002200
1.000
1.000
04010050
4A
Amaranth,
leafy
0.053000
1.000
1.000
04010180
4A
Arugula
0.053000
1.000
1.000
06030300
6C
Bean,
black,
seed
0.130000
1.000
1.000
06020310
6B
Bean,
broad,
succulent
0.014000
1.000
1.000
06030320
6C
Bean,
broad,
seed
0.130000
1.000
1.000
06020330
6B
Bean,
cowpea,
succulent
0.014000
1.000
1.000
06030340
6C
Bean,
cowpea,
seed
0.130000
1.000
1.000
06030350
6C
Bean,
great
northern,
seed
0.130000
1.000
1.000
06030360
6C
Bean,
kidney,
seed
0.130000
1.000
1.000
06020370
6B
Bean,
lima,
succulent
0.014000
1.000
1.000
06030380
6C
Bean,
lima,
seed
0.130000
1.000
1.000
06030390
6C
Bean,
mung,
seed
0.130000
1.000
1.000
06030400
6C
Bean,
navy,
seed
0.130000
1.000
1.000
06030410
6C
Bean,
pink,
seed
0.130000
1.000
1.000
06030420
6C
Bean,
pinto,
seed
0.130000
1.000
1.000
06010430
6A
Bean,
snap,
succulent
0.014000
1.000
1.000
06010431
6A
Bean,
snap,
succulent­
babyfood
0.014000
1.000
1.000
21000440
M
Beef,
meat
0.000610
1.000
1.000
21000441
M
Beef,
meat­
babyfood
0.000610
1.000
1.000
21000450
M
Beef,
meat,
dried
0.000610
1.920
1.000
21000460
M
Beef,
meat
byproducts
0.000150
1.000
1.000
21000461
M
Beef,
meat
byproducts­
babyfood
0.000150
1.000
1.000
21000470
M
Beef,
fat
0.003900
1.000
1.000
21000471
M
Beef,
fat­
babyfood
0.003900
1.000
1.000
21000480
M
Beef,
kidney
0.000150
1.000
1.000
21000490
M
Beef,
liver
0.000016
1.000
1.000
21000491
M
Beef,
liver­
babyfood
0.000016
1.000
1.000
01010520
1A
Beet,
sugar
0.005000
1.000
1.000
01010521
1A
Beet,
sugar­
babyfood
0.005000
1.000
1.000
01010530
1A
Beet,
sugar,
molasses
0.005000
1.000
1.000
01010531
1A
Beet,
sugar,
molasses­
babyfood
0.005000
1.000
1.000
05010610
5A
Broccoli
0.001000
1.000
1.000
05010611
5A
Broccoli­
babyfood
0.001000
1.000
1.000
05010620
5A
Broccoli,
Chinese
0.017500
1.000
1.000
05020630
5B
Broccoli
raab
0.053000
1.000
1.000
05010640
5A
Brussels
sprouts
0.022000
1.000
1.000
05010690
5A
Cabbage
0.001500
1.000
1.000
05020700
5B
Cabbage,
Chinese,
bok
choy
0.017500
1.000
1.000
05010710
5A
Cabbage,
Chinese,
napa
0.022000
1.000
1.000
05010720
5A
Cabbage,
Chinese,
mustard
0.017500
1.000
1.000
04020760
4B
Cardoon
0.053000
1.000
1.000
05010830
5A
Cauliflower
0.002300
1.000
1.000
04020850
4B
Celery
0.017000
1.000
1.000
04020851
4B
Celery­
babyfood
0.017000
1.000
1.000
04020860
4B
Celery,
juice
0.017000
1.000
1.000
04020870
4B
Celtuce
0.017000
1.000
1.000
40000930
P
Chicken,
meat
0.000004
1.000
1.000
40000931
P
Chicken,
meat­
babyfood
0.000004
1.000
1.000
40000940
P
Chicken,
liver
0.000004
1.000
1.000
40000950
P
Chicken,
meat
byproducts
0.000004
1.000
1.000
40000951
P
Chicken,
meat
byproducts­
babyfoo
0.000004
1.000
1.000
40000960
P
Chicken,
fat
0.000120
1.000
1.000
40000961
P
Chicken,
fat­
babyfood
0.000120
1.000
1.000
40000970
P
Chicken,
skin
0.000120
1.000
1.000
40000971
P
Chicken,
skin­
babyfood
0.000120
1.000
1.000
06030980
6C
Chickpea,
seed
0.130000
1.000
1.000
06030981
6C
Chickpea,
seed­
babyfood
0.130000
1.000
1.000
06030990
6C
Chickpea,
flour
0.130000
1.000
1.000
04011040
4A
Chrysanthemum,
garland
0.053000
1.000
1.000
Cypermethrin/
zeta­
cypermethrin
Dietary
Exposure
Assessment
DP
Barcode:
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PC
Code:
109702
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129064
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31
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34
05021170
5B
Collards
0.021000
1.000
1.000
15001200
15
Corn,
field,
flour
0.000054
1.000
1.000
15001201
15
Corn,
field,
flour­
babyfood
0.000054
1.000
1.000
15001210
15
Corn,
field,
meal
0.000054
1.000
1.000
15001211
15
Corn,
field,
meal­
babyfood
0.000054
1.000
1.000
15001220
15
Corn,
field,
bran
0.000054
1.000
1.000
15001230
15
Corn,
field,
starch
0.000054
1.000
1.000
15001231
15
Corn,
field,
starch­
babyfood
0.000054
1.000
1.000
15001240
15
Corn,
field,
syrup
0.000054
1.000
1.000
15001241
15
Corn,
field,
syrup­
babyfood
0.000054
1.000
1.000
15001250
15
Corn,
field,
oil
0.000054
1.000
1.000
15001251
15
Corn,
field,
oil­
babyfood
0.000054
1.000
1.000
15001260
15
Corn,
pop
0.000054
1.000
1.000
15001270
15
Corn,
sweet
0.000140
1.000
1.000
15001271
15
Corn,
sweet­
babyfood
0.000140
1.000
1.000
95001280
O
Cottonseed,
oil
0.025000
1.000
1.000
95001281
O
Cottonseed,
oil­
babyfood
0.025000
1.000
1.000
04011330
4A
Cress,
garden
0.053000
1.000
1.000
04011340
4A
Cress,
upland
0.053000
1.000
1.000
04011380
4A
Dandelion,
leaves
0.053000
1.000
1.000
70001450
P
Egg,
whole
0.000022
1.000
1.000
70001451
P
Egg,
whole­
babyfood
0.000022
1.000
1.000
70001460
P
Egg,
white
0.000022
1.000
1.000
70001461
P
Egg,
white
(
solids)­
babyfood
0.000022
1.000
1.000
70001470
P
Egg,
yolk
0.000066
1.000
1.000
70001471
P
Egg,
yolk­
babyfood
0.000066
1.000
1.000
08001480
8
Eggplant
0.012500
1.000
1.000
04011500
4A
Endive
0.053000
1.000
1.000
04021520
4B
Fennel,
Florence
0.017000
1.000
1.000
20001630
20
Flaxseed,
oil
0.200000
1.000
1.000
03001640
3
Garlic
0.000650
1.000
1.000
03001650
3
Garlic,
dried
0.000650
1.000
1.000
03001651
3
Garlic,
dried­
babyfood
0.000650
1.000
1.000
23001690
M
Goat,
meat
0.000610
1.000
1.000
23001700
M
Goat,
meat
byproducts
0.000150
1.000
1.000
23001710
M
Goat,
fat
0.003900
1.000
1.000
23001720
M
Goat,
kidney
0.000150
1.000
1.000
23001730
M
Goat,
liver
0.000016
1.000
1.000
06031820
6C
Guar,
seed
0.130000
1.000
1.000
06031821
6C
Guar,
seed­
babyfood
0.130000
1.000
1.000
24001890
M
Horse,
meat
0.000610
1.000
1.000
05021940
5B
Kale
0.023000
1.000
1.000
05011960
5A
Kohlrabi
0.017500
1.000
1.000
03001980
3
Leek
0.098000
1.000
1.000
06032030
6C
Lentil,
seed
0.130000
1.000
1.000
04012040
4A
Lettuce,
head
0.006400
1.000
1.000
04012050
4A
Lettuce,
leaf
0.006400
1.000
1.000
27002220
D
Milk,
fat
0.000440
1.000
1.000
27002221
D
Milk,
fat
­
baby
food/
infant
for
0.000440
1.000
1.000
27012230
D
Milk,
nonfat
solids
0.000440
1.000
1.000
27012231
D
Milk,
nonfat
solids­
baby
food/
in
0.000440
1.000
1.000
27022240
D
Milk,
water
0.000440
1.000
1.000
27022241
D
Milk,
water­
babyfood/
infant
form
0.000440
1.000
1.000
27032251
D
Milk,
sugar
(
lactose)­
baby
food/
0.000440
1.000
1.000
05022290
5B
Mustard
greens
0.021000
1.000
1.000
03002370
3
Onion,
dry
bulb
0.000750
1.000
1.000
03002371
3
Onion,
dry
bulb­
babyfood
0.000750
1.000
1.000
03002380
3
Onion,
dry
bulb,
dried
0.000750
9.000
1.000
03002381
3
Onion,
dry
bulb,
dried­
babyfood
0.000750
9.000
1.000
03002390
3
Onion,
green
0.098000
1.000
1.000
04012480
4A
Parsley,
leaves
0.053000
1.000
1.000
06022550
6B
Pea,
succulent
0.014000
1.000
1.000
06022551
6B
Pea,
succulent­
babyfood
0.014000
1.000
1.000
06032560
6C
Pea,
dry
0.130000
1.000
1.000
06032561
6C
Pea,
dry­
babyfood
0.130000
1.000
1.000
06012570
6A
Pea,
edible
podded,
succulent
0.014000
1.000
1.000
06032580
6C
Pea,
pigeon,
seed
0.130000
1.000
1.000
06022590
6B
Pea,
pigeon,
succulent
0.014000
1.000
1.000
14002690
14
Pecan
0.004500
1.000
1.000
08002700
8
Pepper,
bell
0.035000
1.000
1.000
08002701
8
Pepper,
bell­
babyfood
0.035000
1.000
1.000
08002710
8
Pepper,
bell,
dried
0.035000
1.000
1.000
Cypermethrin/
zeta­
cypermethrin
Dietary
Exposure
Assessment
DP
Barcode:
D293419
PC
Code:
109702
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34
08002711
8
Pepper,
bell,
dried­
babyfood
0.035000
1.000
1.000
08002720
8
Pepper,
nonbell
0.061000
1.000
1.000
08002721
8
Pepper,
nonbell­
babyfood
0.061000
1.000
1.000
08002730
8
Pepper,
nonbell,
dried
0.061000
1.000
1.000
25002900
M
Pork,
meat
0.000050
1.000
1.000
25002901
M
Pork,
meat­
babyfood
0.000050
1.000
1.000
25002910
M
Pork,
skin
0.000320
1.000
1.000
25002920
M
Pork,
meat
byproducts
0.000012
1.000
1.000
25002921
M
Pork,
meat
byproducts­
babyfood
0.000012
1.000
1.000
25002930
M
Pork,
fat
0.000320
1.000
1.000
25002931
M
Pork,
fat­
babyfood
0.000320
1.000
1.000
25002940
M
Pork,
kidney
0.000012
1.000
1.000
25002950
M
Pork,
liver
0.000001
1.000
1.000
60003010
P
Poultry,
other,
meat
0.000004
1.000
1.000
60003020
P
Poultry,
other,
liver
0.000004
1.000
1.000
60003030
P
Poultry,
other,
meat
byproducts
0.000004
1.000
1.000
60003040
P
Poultry,
other,
fat
0.000120
1.000
1.000
60003050
P
Poultry,
other,
skin
0.000120
1.000
1.000
04013130
4A
Radicchio
0.006400
1.000
1.000
05023180
5B
Rape
greens
0.021000
1.000
1.000
04023220
4B
Rhubarb
0.053000
1.000
1.000
15003230
15
Rice,
white
0.016000
1.000
1.000
15003231
15
Rice,
white­
babyfood
0.016000
1.000
1.000
15003240
15
Rice,
brown
0.016000
1.000
1.000
15003241
15
Rice,
brown­
babyfood
0.016000
1.000
1.000
15003250
15
Rice,
flour
0.016000
1.000
1.000
15003251
15
Rice,
flour­
babyfood
0.016000
1.000
1.000
15003260
15
Rice,
bran
0.016000
0.600
1.000
15003261
15
Rice,
bran­
babyfood
0.016000
0.600
1.000
03003380
3
Shallot
0.098000
1.000
1.000
26003390
M
Sheep,
meat
0.000610
1.000
1.000
26003391
M
Sheep,
meat­
babyfood
0.000610
1.000
1.000
26003400
M
Sheep,
meat
byproducts
0.000150
1.000
1.000
26003410
M
Sheep,
fat
0.003900
1.000
1.000
26003411
M
Sheep,
fat­
babyfood
0.003900
1.000
1.000
26003420
M
Sheep,
kidney
0.000150
1.000
1.000
26003430
M
Sheep,
liver
0.000016
1.000
1.000
15003440
15
Sorghum,
grain
0.002500
1.000
1.000
15003450
15
Sorghum,
syrup
0.002500
1.000
1.000
06003470
6
Soybean,
seed
0.000150
1.000
1.000
06003480
6
Soybean,
flour
0.000150
1.000
1.000
06003481
6
Soybean,
flour­
babyfood
0.000150
1.000
1.000
06003490
6
Soybean,
soy
milk
0.000150
1.000
1.000
06003491
6
Soybean,
soy
milk­
babyfood
or
in
0.000150
1.000
1.000
06003500
6
Soybean,
oil
0.000150
0.500
1.000
06003501
6
Soybean,
oil­
babyfood
0.000150
0.500
1.000
04013550
4A
Spinach
0.014000
1.000
1.000
04013551
4A
Spinach­
babyfood
0.014000
1.000
1.000
95003620
O
Sugarcane,
sugar
0.180000
0.060
1.000
95003621
O
Sugarcane,
sugar­
babyfood
0.180000
0.060
1.000
95003630
O
Sugarcane,
molasses
0.180000
0.410
1.000
95003631
O
Sugarcane,
molasses­
babyfood
0.180000
0.410
1.000
04023670
4B
Swiss
chard
0.053000
1.000
1.000
08003740
8
Tomatillo
0.000125
1.000
1.000
08003750
8
Tomato
0.000125
1.000
1.000
08003751
8
Tomato­
babyfood
0.000125
1.000
1.000
08003760
8
Tomato,
paste
0.000125
0.500
1.000
08003761
8
Tomato,
paste­
babyfood
0.000125
0.500
1.000
08003770
8
Tomato,
puree
0.000125
0.330
1.000
08003771
8
Tomato,
puree­
babyfood
0.000125
0.330
1.000
08003780
8
Tomato,
dried
0.000125
14.300
1.000
08003781
8
Tomato,
dried­
babyfood
0.000125
14.300
1.000
08003790
8
Tomato,
juice
0.000125
1.500
1.000
50003820
P
Turkey,
meat
0.000004
1.000
1.000
50003821
P
Turkey,
meat­
babyfood
0.000004
1.000
1.000
50003830
P
Turkey,
liver
0.000004
1.000
1.000
50003831
P
Turkey,
liver­
babyfood
0.000004
1.000
1.000
50003840
P
Turkey,
meat
byproducts
0.000004
1.000
1.000
50003841
P
Turkey,
meat
byproducts­
babyfood
0.000004
1.000
1.000
50003850
P
Turkey,
fat
0.000120
1.000
1.000
50003851
P
Turkey,
fat­
babyfood
0.000120
1.000
1.000
50003860
P
Turkey,
skin
0.000120
1.000
1.000
Cypermethrin/
zeta­
cypermethrin
Dietary
Exposure
Assessment
DP
Barcode:
D293419
PC
Code:
109702
&
129064
Page
33
of
34
50003861
P
Turkey,
skin­
babyfood
0.000120
1.000
1.000
05023890
5B
Turnip,
greens
0.020000
1.000
1.000
15004010
15
Wheat,
grain
0.000320
1.000
1.000
15004011
15
Wheat,
grain­
babyfood
0.000320
1.000
1.000
15004020
15
Wheat,
flour
0.000320
0.220
1.000
15004021
15
Wheat,
flour­
babyfood
0.000320
0.220
1.000
15004030
15
Wheat,
germ
0.000320
0.440
1.000
15004040
15
Wheat,
bran
0.000320
1.400
1.000
15004050
15
Wild
rice
0.016000
1.000
1.000
Cypermethrin/
zeta­
cypermethrin
Dietary
Exposure
Assessment
DP
Barcode:
D293419
PC
Code:
109702
&
129064
Page
34
of
34
Attachment
6.
Chronic
Results
U.
S.
Environmental
Protection
Agency
Ver.
1.30
DEEM­
FCID
Chronic
analysis
for
CYPERMETHRIN
(
1994­
98
data)
Residue
file
name:
C:\
BackupFiles\
Cypermethrin\
109702c1.
R98
Adjustment
factor
#
2
NOT
used.
Analysis
Date
02­
27­
2004/
14:
02:
50
Residue
file
dated:
02­
27­
2004/
14:
01:
49/
8
Reference
dose
(
RfD,
Chronic)
=
.006
mg/
kg
bw/
day
COMMENT
1:
Cypermethrin
&
Zeta­
cypermethrin:
updated
ARs
===============================================================================
Total
exposure
by
population
subgroup
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­

Total
Exposure
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Population
mg/
kg
Percent
of
Subgroup
body
wt/
day
Rfd
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­­­­
­­­­­­­­­­­­­­­
U.
S.
Population
(
total)
0.000043
0.7%

U.
S.
Population
(
spring
season)
0.000042
0.7%
U.
S.
Population
(
summer
season)
0.000041
0.7%
U.
S.
Population
(
autumn
season)
0.000043
0.7%
U.
S.
Population
(
winter
season)
0.000044
0.7%

Northeast
region
0.000039
0.7%
Midwest
region
0.000038
0.6%
Southern
region
0.000041
0.7%
Western
region
0.000052
0.9%

Hispanics
0.000071
1.2%
Non­
hispanic
whites
0.000037
0.6%
Non­
hispanic
blacks
0.000043
0.7%
Non­
hisp/
non­
white/
non­
black
0.000072
1.2%

All
infants
(<
1
year)
0.000049
0.8%
Nursing
infants
0.000025
0.4%
Non­
nursing
infants
0.000057
1.0%
Children
1­
6
yrs
0.000085
1.4%
Children
7­
12
yrs
0.000054
0.9%

Females
13­
19
(
not
preg
or
nursing)
0.000034
0.6%
Females
20+
(
not
preg
or
nursing)
0.000033
0.5%
Females
13­
50
yrs
0.000041
0.7%
Females
13+
(
preg/
not
nursing)
0.000047
0.8%
Females
13+
(
nursing)
0.000051
0.9%

Males
13­
19
yrs
0.000041
0.7%
Males
20+
yrs
0.000039
0.6%
Seniors
55+
0.000033
0.6%

Children
1­
2
yrs
0.000095
1.6%
Children
3­
5
yrs
0.000083
1.4%
Children
6­
12
yrs
0.000057
0.9%
Youth
13­
19
yrs
0.000038
0.6%
Adults
20­
49
yrs
0.000037
0.6%
Adults
50+
yrs
0.000034
0.6%
Females
13­
49
yrs
0.000035
0.6%

­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
