Page
of
2
1
UNITED
STATES
ENVIRONMENTAL
PROTECTION
AGENCY
WASHINGTON,
D.
C.
20460
OFFICE
OF
PREVENTION,
PESTICIDES
AND
TOXIC
SUBSTANCES
February
28,
2006
MEMORANDUM
SUBJECT:
Dicloran:
HED
Response
to
Public
Comments­
Phase
4.
PC
Code:
031301,
Case
#:
0113,
DP
Barcode:
D325652.
Regulatory
Action:
Phase
4
­
HED
Response
to
Registrant's
Public
Comments
Risk
Assessment
Type:
Single
Chemical
Aggregate
FROM:
Toiya
Goodlow,
Risk
Assessor
Byong­
Han
Chin,
Ph.
D.,
Toxicologist
Christine
L.
Olinger,
Chemist
Matthew
G.
Lloyd,
M.
S.,
Industrial
Hygienist
Reregistration
Branch
1
Health
Effects
Division
(
7509C)

THROUGH:
Whang
Phang,
Ph.
D.,
Branch
Senior
Scientist
Reregistration
Branch
1
Health
Effects
Division
(
7509C)

TO:
James
Parker,
Chemical
Review
Manager
Special
Review
and
Reregistration
Division
(
7508C)

This
document
was
written
in
response
to
public
comments
submitted
for
the
Human
Health
Risk
Assessment
for
the
Dicloran
Reregistration
Eligibility
Decision
Document
(
RED).
All
comments
have
been
reviewed
by
RRB1/
HED
and
incorporated
into
the
Revised
Human
Health
Risk
Assessment
for
the
Dicloran
RED
(
D325653,
2/
28/
06,
T.
Goodlow)
as
deemed
appropriate
by
the
Agency.

Changes
include
the
following:

Toxicology
Page
of
2
2
°
After
reevaluation,
HED
has
determined
that
the
developmental
neurotoxicity
study
requirement
will
remain,
in
addition
to
a
10X
FQPA
database
uncertainty
factor.
The
risk
assessment
has
been
revised
to
reflect
a
total
uncertainty
factor
of
1000
for
acute
and
chronic
reference
doses
(
10x
for
intraspecies
variation;
10x
for
interspecies
extrapolation;
10X
for
database
uncertainty
factor).

Occupational/
Residential
Exposure
Although,
public
comments
were
not
submitted,
HED
addressed
several
issues
during
this
phase.

°
The
submission
of
new
label
information
permitted
HED
to
perform
an
assessment
for
greenhouse
seed
potatoes
or
transplants.

°
The
inclusion
of
revised
product
label
information
resulted
in
the
elimination
of
chronic
exposure
scenarios
for
cut
flowers.

°
Newly
submitted
application
rate
data
from
SRRD
was
included
in
the
worker
postapplication
risk
assessments
for
those
crops
where
postapplication
risks
exceeded
HED's
level
of
concern
at
Day
0.

Chemistry
°
The
addition
of
the
10X
database
uncertainty
safety
factor
warranted
a
new
dietary
assessment.
Updated
dietary
exposure
and
risk
estimates
are
included
in
the
dicloran
revised
risk
assessment.

References
Goodlow,
Toiya.
DP
Barcode:
D325653.
February
28,
2006.
Dicloran:
Revised
HED
Chapter
of
the
Reregistration
Eligibility
Decision
Document
(
RED),
Phase
3
Public
Comments.

7509C:
RRB1:
TGoodlow:
CM#
2:
Rm
722H:
308­
0070:
2/
28/
06
WPhang:
2/
28/
06
