1
of
44
UNITED
STATES
ENVIRONMENTAL
PROTECTION
AGENCY
WASHINGTON,
D.
C.
20460
OFFICE
OF
PREVENTION,
PESTICIDES,
AND
TOXIC
SUBSTANCES
MEMORANDUM
Date:
November
23,
2005
Subject:
Triadimefon.
Summary
of
Analytical
Chemistry
and
Residue
Data
for
the
Reregistration
Eligibility
Decision
(
RED)
Document.

DP
Barcode:
D314742
PC
Code:
109901
40
CFR
§
:
180.410
Chemical
Class:
Triazole
From:
Samuel
Ary,
Chemist
Reregistration
Branch
II
Health
Effects
Division
(
7509C)

Through:
Yvonne
Barnes,
Chemist
Reregistration
Branch
II
Health
Effects
Division
(
7509C)

Chemistry
Science
Advisory
Council
Health
Effects
Division
(
7509C)

William
Hazel,
Branch
Chief
Reregistration
Branch
II
Health
Effects
Division
(
7509C)

To:
Richard
Griffin,
Risk
Assessor
Reregistration
Branch
II
Health
Effects
Division
(
7509C)

John
Pates,
Chemical
Review
Manager
Reregistration
Branch
I
Special
Review
and
Reregistration
Division
(
7508C)
Triadimefon
Summary
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
314742
2
of
44
Executive
Summary
Triadimefon,
1­(
4­
chlorophenoxy)­
3,3­
dimethyl­
1­(
1H­
1,2,4­
triazol­
1­
yl)­
2­
butanone,
is
a
systemic
fungicide
used
to
control
rust
and
mildew
on
apples,
grapes,
pears,
pineapples,
and
raspberries.
Triadimefon
end­
use
products
are
marketed
in
the
United
States
under
the
trade
name
Bayleton
®
and
Summit
®
.
The
reregistration
of
triadimefon
is
being
supported
by
Bayer
CropScience
(
Bayer;
formerly
Miles,
Inc.
and
Mobay
Chemical
Corporation),
the
basic
producer.
The
Bayer
triadimefon
formulations
registered
for
food/
feed
uses
include
wettable
powder
(
WP)
and
flowable
concentrate
(
FlC)
formulations.

Tolerances
are
established
for
residues
of
triadimefon
and
its
metabolites
containing
chlorophenoxy
and
triazole
moieties
(
expressed
as
the
parent
compound)
in/
on
various
plant
and
livestock
commodities
(
40
CFR
§
180.410).
The
established
permanent
tolerances
for
residues
in
plant
and
livestock
commodities
[
40
CFR
§
180.410(
a)]
range
from
0.04
ppm
(
milk,
hog,
and
poultry
commodities)
to
145
ppm
(
grass
seed
cleanings).
A
tolerance
with
regional
registration
is
established
for
triadimefon
and
its
metabolites
in/
on
raspberries
at
2.0
ppm
[
40
CFR
§
180.410(
c)].

Residues
of
triadimenol
[$­(
4­
chlorophenoxy)­"­(
1,1­
dimethylethyl)­
1H­
1,2,4­
triazole­
1­
ethanol]
and
its
butanediol
metabolite
[
1­(
4­
chlorophenoxy)­
3,3­
dimethyl­
3­
hydroxymethyl­
1­(
1H­
1,2,4­
triazol­
1­
yl)­
2­
butanol;
KWG
1342],
from
use
of
triadimenol,
are
regulated
separately
under
40
CFR
§
180.450.
In
addition,
40
CFR
§
180.3(
d)(
13)
specifies
that
where
tolerances
are
established
for
residues
of
both
triadimefon
and
triadimenol
including
its
butanediol
metabolite,
in
or
on
the
same
raw
agricultural
commodity
and
its
products
thereof,
the
total
amount
of
such
residues
shall
not
yield
more
residue
than
that
permitted
by
the
higher
of
the
two
tolerances.
Currently,
triadimefon
and
triadimenol
do
not
share
any
uses,
so
40
CFR
§
180.3(
d)(
13)
should
be
deleted.

The
reregistration
requirements
for
plant
metabolism
are
fulfilled
based
on
adequate
metabolism
studies
conducted
with
grapes,
cucumbers,
tomatoes,
and
wheat.
On
December
1,
1993
the
Health
Effects
Division
(
HED)
Metabolism
Assessment
Review
Committee
(
MARC)
concluded
that
for
plants,
the
residues
of
concern
consist
of
triadimefon,
triadimenol,
KWG
1323
[
1­(
4­
chlorophenoxy)­
3,3­
dimethyl­
3­
hydroxymethyl­
1­(
1H­
1,2,4­
triazol­
1­
yl)­
2­
butanone],
KWG
1342,
and
in
cereal
grains,
triadimefon,
triadimenol,
KWG
1323,
KWG
1342,
and
KWG
1732
[
1­
(
4­
chlorophenoxy)­
1­(
1H­
1,2,4­
triazol­
1­
yl)
ethanoic
acid]
(
S.
Knizner,
HED
MARC
Memorandum,
1/
3/
1994).
HED
has
revisited
the
MARC
decision
and
determined
that
the
triadimefon
residues
of
concern
in/
on
apples,
grapes,
pears,
pineapples,
and
raspberries
for
tolerance
expression
are
triadimefon
and
triadimenol
and
for
risk
assessment
are
triadimefon,
triadimenol,
KWG
1323,
and
KWG
1342.

Additionally,
the
Agency
does
have
concern
about
the
potential
toxicity
of
1,2,4­
triazole
and
two
conjugates,
triazole
alanine
and
triazole
acetic
acid,
which
are
metabolites
common
to
most
of
the
triazole
fungicides.
To
support
the
extension
of
existing
and
granting
of
new
parent
triazolederivative
fungicide
tolerances,
the
Agency
will
be
conducting
a
human­
health
assessment
for
aggregate
exposure
to
1,2,4­
triazole.

The
reregistration
requirements
for
livestock
metabolism
are
fulfilled
based
on
acceptable
goat
and
poultry
metabolism
studies.
HED
has
determined
that
the
residues
of
concern
for
tolerance
expression
and
risk
assessment
in
livestock
are
triadimefon,
triadimenol,
KWG
1323,
and
KWG
Triadimefon
Summary
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
314742
3
of
44
1342.

If
registration
on
additional
commodities
and
livestock
feed
items
are
requested,
then
triazole
and
phenyl­
labeled
plant
and
livestock
metabolism
studies
would
be
required.
Such
data
may,
in
turn,
trigger
the
need
for
magnitude
of
the
residue
studies
conducted
with
plants
and
livestock.

Two
gas
chromatography
with
mass
spectrometry
detection
(
GC/
MS)
methods
are
listed
in
PAM
Vol.
II
for
enforcement
of
tolerances
for
plant
and
livestock
commodities.
The
methods
use
a
single
moiety
detection
in
which
residues
are
converted
to
p­
dichlorophenol,
derivatized
with
dinitrofluorobenzene,
and
reported
as
triadimefon
equivalents.
The
GC/
MS
method
is
no
longer
adequate
due
to
the
recommended
tolerance
expression
revisions.
However,
a
GC
method
using
a
nitrogen
phosphorus
detector
(
NPD;
Report
No.
80488)
is
available
for
determination
of
residues
of
triadimefon,
triadimenol,
KWG
1323,
and
KWG
1342
and
is
adequate
for
the
enforcement
of
apple,
grape,
pear,
pineapple,
and
raspberry
tolerances.
The
reported
method
limit
of
quantitation
(
LOQ)
is
0.01
ppm
for
each
analyte.
The
limit
of
detection
(
LOD)
was
not
reported.

The
reregistration
requirements
for
multiresidue
method
testing
for
residues
of
triadimefon
and
its
metabolites
are
satisfied.
The
10/
99
FDA
PESTDATA
database
(
PAM
Volume
I,
Appendix
I)
indicates
that
triadimefon
is
completely
recovered
(>
80%)
using
Multiresidue
Methods
Section
302
(
Luke
Method;
Protocol
D).
Triadimenol
is
completely
recovered
using
Section
302.

The
reregistration
requirements
for
storage
stability
data
are
satisfied.
Adequate
storage
stability
data
for
plant
and
livestock
commodities
have
been
submitted
and
evaluated.

The
reregistration
requirements
for
magnitude
of
the
residue
in/
on
the
following
raw
agricultural
commodities
(
RACs)
based
on
the
currently
registered
use
patterns
are
fulfilled
pending
label
revisions
and/
or
tolerance
adjustments:
apples,
grapes,
pears,
pineapples,
and
raspberries.

The
reregistration
requirements
for
data
depicting
the
magnitude
of
triadimefon
residues
of
concern
in
meat,
milk,
poultry,
and
eggs
have
been
fulfilled.
Acceptable
ruminant
and
poultry
feeding
studies
have
been
submitted
and
evaluated.
Triadimefon
is
not
registered
for
use
as
a
direct
livestock
treatment.
HED
concludes
that
the
supported
registered
uses
on
apples,
grapes,
pears,
pineapples,
and
raspberries
result
in
a
40
CFR
§
180.6(
a)(
3)
situation
for
ruminant
commodities;
i.
e.,
there
is
no
reasonable
expectation
of
finite
residues
in
ruminant
commodities.
Therefore,
additional
data
on
the
transfer
of
residues
to
meat,
milk,
poultry,
and
eggs
are
not
required
and
all
tolerances
for
livestock
commodities
should
be
revoked.
If
registration
on
additional
livestock
feed
items
are
requested,
livestock
tolerances
may
need
to
be
reinstated.

A
general
summary
of
residue
chemistry
deficiencies
are
listed
below;
details
of
data
requirements
are
listed
in
Table
5.

Regulatory
Recommendations
and
Residue
Chemistry
Deficiencies
°
Cucurbit
uses
should
be
removed
from
all
labels
and
the
registrant
should
submit
recent
copies
of
product
labels
showing
the
uses
have
been
removed.
Triadimefon
Summary
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
314742
4
of
44
Cl
O
N
N
N
O
°
Product
labels
(
EPA
Reg.
Nos.
264­
737
and
432­
1294)
must
be
modified
to
specify
that
aerial
applications
to
orchard
crops
be
made
in
a
minimum
of
10
gal/
A.
Alternatively,
the
registrant
may
submit
crop
field
trial
data
for
orchard
crops
reflecting
application
in
5
gal/
A
using
aerial
equipment.

°
The
product
labels
for
all
triadimefon
formulations
should
be
modified
to
remove
the
rotational
crop
restrictions.

°
The
pineapple
field
trial
data
submitted
did
not
indicate
whether
the
dipping
solutions
were
newly
prepared
each
day
or
prepared
once
and
then
reused
for
subsequent
dips.
This
is
a
deficiency
and
the
registrant
must
state
if
dipping
solutions
were
prepared
fresh
each
day
or
prepared
once
and
reused.

Background
The
Triadimefon
Phase
4
Review
dated
1/
31/
1991
by
S.
Funk
and
the
subsequent
Triadimefon
Data
Call
In
(
DCI)
Notice
dated
4/
29/
1992
summarized
the
status
of
available
residue
chemistry
data
for
the
reregistration
of
triadimefon.
The
Phase
4
Review
identified
several
data
deficiencies
including
plant
and
livestock
metabolism,
residue
analytical
methods,
storage
stability,
and
magnitude
of
the
residue
in
plants.
Several
studies
have
been
submitted
and
evaluated
in
response
to
the
Triadimefon
DCI.
This
document
presents
an
overall
and
up­
to­
date
Residue
Chemistry
Science
Assessment
with
respect
to
the
reregistration
of
triadimefon.
The
PC
Code
and
nomenclature
of
triadimefon
are
listed
below
in
Table
1
and
the
physicochemical
properties
are
listed
in
Table
2.
The
structure
of
triadimefon
and
metabolites
of
concern
are
presented
in
Table
3.

Table
1.
Triadimefon
Nomenclature.

Chemical
structure
Common
name
Triadimefon
Molecular
formula
C14H16ClN3O2
IUPAC
name
(
RS)­
1­(
4­
chlorophenoxy)­
3,3­
dimethyl­
1­(
1H­
1,2,4­
triazol­
1­
yl)­
butan­
2­
one
CAS
name
1­(
4­
chlorophenoxy)­
3,3­
dimethyl­
1­(
1H­
1,2,4­
triazol­
1­
yl)­
2­
butanone
CAS
number
43121­
43­
3
PC
Code
109901
Current
food/
feed
site
registration
apple,
grape,
pear,
pineapple,
and
raspberry
Triadimefon
Summary
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
314742
5
of
44
Cl
O
N
N
N
O
Cl
O
N
N
N
OH
Cl
O
N
N
N
O
OH
Table
2.
Physicochemical
Properties
of
Triadimefon
Parameter
Value
Reference
Molecular
weight
293.75
g/
mol
Merck
Index
12th
Edition
Melting
point/
range
82.3
°
C
MRID
41616001
pH
5.5
in
a
1%
suspension
compared
to
water
MRID
41616001
Density
at
20
°
C
1.23
g/
mL
MRID
41616001
Water
solubility
at
20
°
C
64
mg/
L
MRID
41616001
Solvent
solubility
at
25
°
C
Moderately
soluble
in
most
organic
solvents
except
aliphatics
MRID
41616001
Vapor
pressure
0.2
mPa
at
20
°
C
MRID
42307801
0.6
mPa
at
25
°
C
Octanol/
water
partition
coefficient
log
Po/
w
of
3.11
at
22
°
C
MRID
42307801
Table
3.
Chemical
Names
and
Structures
of
Triadimefon
and
Its
Metabolites.

Common
name
and
chemical
name
Chemical
structure
Triadimefon
1­(
4­
chlorophenoxy)­
3,3­
dimethyl­
1­(
1H­
1,2,4­
triazol­
1­
yl)­
2­
butanone
Triadimenol
(
KWG
0519)

$­(
4­
chlorophenoxy)­"­(
1,1­
dimethylethyl)­
1H­
1,2,4­
triazole­
1­
ethanol
KWG
1323
1­(
4­
chlorophenoxy)­
3,3­
dimethyl­
3­
hydroxymethyl­
1­(
1H­
1,2,4­
triazol­
1­
yl)­
2­
butanone
Triadimefon
Summary
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
314742
Table
3.
Chemical
Names
and
Structures
of
Triadimefon
and
Its
Metabolites.

Common
name
and
chemical
name
Chemical
structure
6
of
44
Cl
O
N
N
N
OH
OH
Cl
O
N
N
N
O
OH
KWG
1342
1­(
4­
chlorophenoxy)­
3,3­
dimethyl­
3­
hydroxymethyl­
1­(
1H­
1,2,4­
triazol­
1­
yl)­
2­
butanol
KWG
1732
1­(
4­
chlorophenoxy)­
1­(
1H­
1,2,4­
triazol­
1­
yl)
ethanoic
acid
Summary
of
Science
Findings
860.1200
Directions
for
Use
Product
List
There
is
one
Bayer
CropScience
and
two
Bayer
Environmental
Science
end­
use
products
containing
the
active
ingredient
triadimefon
which
are
registered
for
use
on
domestically
grown
food/
feed
crops
as
indicated
in
Table
4.
In
addition,
there
is
one
SLN
registration
(
HI030004)
for
use
of
triadimefon
on
pineapple.

Table
4.
Triadimefon
End­
use
Products
(
EPs)
Registered
by
Bayer
CropScience.

EPA
Reg.
No.
Formulation
Registrant
Product
Name
264­
7372
50%
WP1
Bayer
CropScience
Bayleton
®
50%
Wettable
Powder
Fungicide
432­
1293
25%
WP1
Bayer
Environmental
Science
Bayleton
®
25%
Wettable
Powder
Fungicide
432­
1294
50%
WP1
Bayer
Environmental
Science
Bayleton
®
50%
Wettable
Powder
Fungicide
In
Water
Soluble
Packets
1.
WP=
Wettable
Powder
and
FlC=
Flowable
Concentrate.
2.
Including
SLN
No.
HI030004
for
application
of
triadimefon
to
pineapple
in
Hawaii.

Use
Pattern
Table
A
comprehensive
summary
of
triadimefon
food/
feed
use
patterns
based
on
the
product
labels
registered
to
Bayer,
was
prepared
by
the
Biological
and
Economic
Analysis
Division
(
BEAD;
dated
5/
9/
2005)
and
is
presented
in
Appendix
1.
A
tabular
summary
of
the
residue
chemistry
science
assessments
for
reregistration
of
triadimefon
is
presented
in
Table
5.
The
conclusions
Triadimefon
Summary
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
314742
7
of
44
listed
in
Table
5
regarding
the
reregistration
eligibility
of
triadimefon
food/
feed
uses
are
based
on
the
use
patterns
being
supported
by
the
basic
producer,
Bayer.
When
end­
use
product
data
call
in's
(
DCIs)
are
developed
(
e.
g.,
at
issuance
of
the
RED),
the
Registration
Division
(
RD)
should
require
that
all
end­
use
product
labels
(
e.
g.,
MAI
labels,
special
local
needs
(
SLNs),
and
products
subject
to
the
generic
data
exemption)
be
amended
such
that
they
are
consistent
with
labels
registered
to
Bayer.

The
basic
producer
has
requested
the
deletion
of
certain
uses
from
product
labels
which
have
not
yet
been
removed.
For
the
25%
WP
formulation
(
EPA
Reg.
No.
432­
1293),
Bayer
requested
that
uses
on
cucurbits
be
removed
(
62
R
30578,
6/
24/
97).
Uses
on
cucurbits
still
remain
on
the
product
label
for
the
25%
WP
formulation.
For
the
purpose
of
generating
this
chemistry
summary
document,
it
was
assumed
that
these
uses
will
be
removed
from
product
labels.
The
registrant
should
submit
recent
copies
of
the
product
labels
for
the
25%
WP
formulations.

The
product
labels
for
the
50%
WP
formulations
(
EPA
Reg.
Nos.
264­
737
and
432­
1294)
must
be
modified
to
specify
that
aerial
applications
to
orchard
crops
be
made
in
a
minimum
of
10
gal/
A.
Alternatively,
the
registrant
may
submit
crop
field
trial
data
for
orchard
crops
reflecting
application
in
5
gal/
A
using
aerial
equipment.

The
product
labels
for
all
triadimefon
formulations
should
be
modified
to
remove
the
rotational
crop
restrictions.
The
basic
producer
is
not
supporting
use
of
triadimefon
on
any
rotatable
crops.

Table
5.
Residue
Chemistry
Science
Assessment
for
the
Reregistration
of
Triadimefon.

GLN
Data
Requirements
Current
Tolerances,
ppm
[
40
CFR]
Must
Additional
Data
Be
Submitted?
References1
860.1200
Directions
for
Use
Not
applicable
(
N/
A)
Yes2
See
Appendix
1
860.1300
Plant
Metabolism
N/
A
No
42123401­
421234033,
427989014,
428534015,6,
92188025­
92188033
860.1300
Livestock
Metabolism
N/
A
No
421234043,
428568016,7,
428649016,8,
43418301­
434183029,
92188034­
92188039
860.1340
Residue
Analytical
Methods
Plant
commodities
N/
A
No
4387010111,
4404100211,
92188040­
92188043
Livestock
commodities
N/
A
No13
434183039,
92188044­
92188048
860.1360
Multiresidue
Methods
N/
A
No
4197660114,
4370540115
860.1380
Storage
Stability
Data
Triadimefon
Summary
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
314742
Table
5.
Residue
Chemistry
Science
Assessment
for
the
Reregistration
of
Triadimefon.

GLN
Data
Requirements
Current
Tolerances,
ppm
[
40
CFR]
Must
Additional
Data
Be
Submitted?
References1
8
of
44
Plant/
processed
commodities
N/
A
No
4197660216,
4285740117,
4403890111,
4404100111,
92188051­
92188053
Livestock
commodities
N/
A
No
4346240118
860.1400
Water,
Fish,
and
Irrigated
Crops
N/
A
N/
A
860.1460
Food
Handling
N/
A
N/
A
860.1480
Meat,
Milk,
Poultry,
and
Eggs
Milk
and
the
Fat,
Meat,
and
Meat
Byproducts
of
Cattle,
Goats,
Hogs,
Horses,
and
Sheep
0.04,
milk;
0.04,
fat,
meat
and
mbyp
of
hogs;
1.0,
fat,
meat,
and
mbyp
of
cattle,
goats,
horses,
and
sheep
[
§
180.410(
a)]
No
92188054,
92188055
Eggs
and
the
Fat,
Meat,
and
Meat
Byproducts
of
Poultry
0.04,
eggs,
fat,
meat,
and
mbyp
[
§
180.410(
a)]
No
92188056,
92188057
860.1500
Crop
Field
Trials
Root
and
Tuber
Vegetables
Group
Beet,
sugar
0.5
[
§
180.410(
a)]
No19
92188063,
92188065,
92188069,
92188073
Leaves
of
Root
and
Tuber
Vegetables
Group
Beet,
sugar,
tops
3.0
[
§
180.410(
a)]
No19
92188063,
92188073
Legume
Vegetables
Group
Chickpea,
dry
0.1
[
§
180.410(
a)]
No20
92188060,
92188070
Cucurbit
Vegetables
Group
Cucumbers
0.3
[
§
180.410(
a)]
No2
42342305
23
Melons
No2
4234230423
Summer
squash
No2
4234230823
Pome
Fruits
Group
Triadimefon
Summary
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
314742
Table
5.
Residue
Chemistry
Science
Assessment
for
the
Reregistration
of
Triadimefon.

GLN
Data
Requirements
Current
Tolerances,
ppm
[
40
CFR]
Must
Additional
Data
Be
Submitted?
References1
9
of
44
Apple
1.0
[
§
180.410(
a)]
No
4234230323,24
Pear
1.0
[
§
180.410(
a)]
No
4234230623,24
Stone
Fruits
Group
Nectarines
4.0
[
§
180.410(
a)]
No25
Berries
Group
Raspberries
2.0
[
§
180.410(
c)]
No
92188061
Cereal
Grains
Group
Wheat,
grain
and
aspirated
grain
fractions
1.0,
grain
[
§
180.410(
a)]
No26
92188064,
92188074
Fodder,
Forage,
Hay,
and
Straw
of
Cereal
Grains
Group
Wheat,
forage,
hay,
and
straw
15.0,
forage;
5.0,
straw
[
§
180.410(
a)]
No26
92188064,
92188074
Grass
Forage,
Fodder,
and
Hay
Group
Grass,
seed
screenings,
forage,
hay,
and
straw
0.2,
forage;
145.0,
seed
screenings;
105.0,
straw,
grown
for
seed
[
§
180.410(
a)]
No27
92188062,
92188075
Miscellaneous
Commodities
Grapes
1.0
[
§
180.410(
a)]
No
4180940123
Pineapple
3.0
[
§
180.410(
a)]
Yes31
4234230723
860.1520
Processed
Food/
Feed
Apple
4.0,
wet
and
dry
pomace
[
§
180.410(
a)]
No
4234660124,10,
4394860129
Beet,
sugar
None
established
No19
92188065,
92188069
Triadimefon
Summary
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
314742
Table
5.
Residue
Chemistry
Science
Assessment
for
the
Reregistration
of
Triadimefon.

GLN
Data
Requirements
Current
Tolerances,
ppm
[
40
CFR]
Must
Additional
Data
Be
Submitted?
References1
10
of
44
Grape
3.0,
wet
and
dry
pomace;
7.0,
raisin
waste
[
§
180.410(
a)]
No
4328440128
Pineapple
None
established
No
4201320121
Wheat
4.0,
milled
fractions
(
except
flour)
[
§
180.410(
a)]
No26
92188064,
92188074
860.1650
Submittal
of
Analytical
Reference
Standards
N/
A
Yes30
860.1850
Confined
Rotational
Crops
N/
A
No
426133016,22
860.1900
Field
Rotational
Crops
None
established
No12
1.
Bolded
references
were
evaluated
in
the
Triadimefon
Phase
4
Review
dated
1/
31/
91,
by
S.
Funk.
All
other
references
were
reviewed
as
noted.

2.
Bayer
has
requested
the
deletion
of
certain
uses
from
product
labels
which
have
not
yet
been
removed.
For
the
25%
WP
formulation
(
EPA
Reg.
No.
432­
1293),
Bayer
requested
that
uses
on
cucurbits
be
removed
(
62
R
30578,
6/
24/
97).
Uses
on
cucurbits
still
remain
on
the
product
label
for
the
25%
WP
formulation.
For
the
purpose
of
generating
this
chemistry
summary
document,
it
was
assumed
that
these
uses
will
be
removed
from
product
labels.
The
registrant
should
submit
recent
copies
of
the
product
labels
for
the
25%
WP
formulations.

The
product
labels
for
the
50%
WP
formulations
(
EPA
Reg.
Nos.
264­
737
and
432­
1294)
must
be
modified
to
specify
that
aerial
applications
to
orchard
crops
be
made
in
a
minimum
of
10
gal/
A.
Alternatively,
the
registrant
may
submit
crop
field
trial
data
for
orchard
crops
reflecting
application
in
5
gal/
A
using
aerial
equipment.

Assuming
that
uses
on
cucurbits
are
removed
from
the
25%
WP
formulation,
the
product
labels
for
all
triadimefon
formulations
should
be
modified
to
remove
the
rotational
crop
restrictions.
The
basic
producer
is
not
supporting
use
of
triadimefon
on
any
rotatable
crops.

3.
C.
Swartz,
D174151,
9/
23/
92.

4.
C.
Swartz,
D194719,
10/
20/
93.

5.
S.
Knizner,
D194676,
11/
3/
93.

6.
S.
Knizner,
Memorandum,
no
DP
Barcode,
12/
9/
93.

7.
S.
Knizner,
D194819,
11/
2/
93.

8.
S.
Knizner,
D194786,
11/
2/
93.

9.
S.
Knizner,
D208890,
12/
16/
94.

10.
S.
Funk,
D179962,
7/
24/
92.
Triadimefon
Summary
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
314742
11
of
44
11.
J.
Punzi,
D222403,
D227497,
and
D227543,
MRID
44038901,43870101,
and
44041002,
7/
13/
00.

12.
Based
on
the
results
of
the
confined
rotational
crop
study,
limited
and/
or
extensive
field
rotational
crop
studies
were
required.
However,
the
registrant
has
since
requested
removal
of
all
rotatable
crop
uses
from
product
labels.
If
uses
on
cucurbits
and
sugar
beets
have
been
removed
from
product
labels,
no
additional
data
pertaining
to
confined/
field
accumulation
in
rotational
crops
will
be
required.

13.
Additional
data
on
livestock
residue
analytical
methods
are
not
required
if
all
tolerances
for
livestock
commodities
are
revoked.

14.
Forwarded
to
FDA
for
inclusion
in
PAM
Vol.
I
(
L.
Edwards
memo
of
6/
30/
92).

15.
Forwarded
to
FDA
for
inclusion
in
PAM
Vol.
I.

16.
S.
Hummel,
D168542
and
D178884,
12/
22/
92.

17.
S.
Knizner,
D194783,
11/
17/
93.

18.
S.
Knizner,
D210160,
2/
23/
95.

19.
Bayer
does
not
currently
have
any
registered
uses
of
triadimefon
on
sugar
beats.

20.
Bayer
does
not
currently
have
any
registered
uses
of
triadimefon
on
chickpea
plants.

21.
F.
Toghrol,
D175489,
9/
18/
92;
Amended
Registrations
Team,
D209623
and
D209629,
2/
21/
95.

22.
S.
Knizner,
D186937,
11/
3/
93.

23.
S.
Knizner,
D179335,
D181031,
and
D181032,
12/
10/
92.

24.
Data
in
this
MRID
were
evaluated
in
conjunction
with
a
petition
(
PP#
3E4164)
to
establish
a
crop
group
tolerance
for
pome
fruits
(
D.
Davis,
D183726,
2/
13/
93).

25.
The
Phase
4
Review
noted
that
the
registered
uses
on
stone
fruits
had
been
removed
from
product
labels.
There
are
currently
no
registered
uses
of
triadimefon
on
nectarines
on
Bayer
product
labels;
the
established
tolerance
should
be
revoked.

26.
Bayer
does
not
currently
have
any
registered
uses
of
triadimefon
on
wheat.

27.
Bayer
does
not
currently
have
any
registered
uses
of
triadimefon
on
pasture,
rangeland,
or
grass
grown
for
seed.

28.
S.
Knizner,
D205423,
2/
23/
95.

29.
S.
Ary,
D321636,
MRID
43948601,
8/
31/
05.

30.
Analytical
reference
standards
must
be
replenished
as
requested
by
the
Repository.

31.
The
pineapple
field
trial
data
submitted
did
not
indicate
whether
the
dipping
solutions
were
newly
prepared
each
day
or
prepared
once
and
then
reused
for
subsequent
dips.
This
is
a
deficiency
and
the
registrant
must
state
if
dipping
solutions
were
prepared
fresh
each
day
or
prepared
once
and
reused.
Triadimefon
Summary
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
314742
12
of
44
860.1300
Nature
of
the
Residue
­
Plants
The
reregistration
requirements
for
plant
metabolism
are
fulfilled
based
on
adequate
metabolism
studies
conducted
with
grapes,
cucumbers,
tomatoes,
and
wheat.

Apple
(
MRID
42123402)

The
Mobay
study
depicting
metabolism
of
3,5­
C­
triazol­
ring
and
uniformly,
phenyl­
ring­
labeled
[
14C]
triadimefon
in
apples
was
found
to
be
deficient,
due
to
the
fact
that
metabolite
identifications
made
using
TLC
were
not
confirmed.
The
Phase
4
review
(
S.
Funk,
1/
31/
91)
data
gap
for
Guideline
Number
(
GLN)
860.1300
cited
the
lack
of
raw
data
and
sample
chromatograms
supporting
the
apple
metabolism
study
as
deficiencies.

The
additional
supporting
data
submitted
by
the
registrant
(
MRID
42123402)
included
raw
data
(
i.
e.
sample
weights
and
ppm
data),
as
well
as
one
set
of
thin
layer
chromatography
(
TLC)
chromatograms
for
the
benzene
wash,
and
organosoluble
fractions
from
the
peel
and
pulp.
The
raw
data
support
the
values
reported
in
Tables
I
through
VII
of
the
original
submission,
with
a
few
minor
corrections.
The
sample
TLC
is
difficult
to
read,
and
locations
of
the
unidentified
metabolite
were
not
clearly
labeled.
In
addition,
there
were
no
data
submitted
for
confirmation
of
the
TLC
results,
i.
e.
high­
performance
liquid
chromatography
(
HPLC)
or
GC/
MS.
Consequently,
the
additional
submission
has
not
rendered
the
study
acceptable.
The
need
for
an
additional
apple
metabolism
study
has
been
waived
after
reevaluation
of
the
cucumber,
tomato,
grape,
and
wheat
metabolism
studies.
However,
if
confirmatory
GC/
MS
or
MS
spectra,
or
HPLC
chromatograms
confirming
metabolite
identities
are
available,
they
should
be
submitted
to
the
Agency
for
review.
If
the
registrant
intends
to
conduct
an
additional
apple
metabolism
study,
HED
strongly
recommends
that
application
of
the
radiolabeled
formulation
include
foliar
contact.

Cucumber
and
Tomato
(
MRID
42123401)

In
the
cucumber
and
tomato
metabolism
studies,
seedlings
were
treated
with
[
phenyl­
14C]
triadimefon
at
approximately
1x
the
maximum
rate
for
cucumbers.
Selected
plants
were
treated
two
additional
times,
beginning
at
fruit
set.
Metabolism
of
triadimefon
in
tomato
and
cucumber
seedlings
receiving
a
single
foliar
application
appears
to
consist
of
rapid
degradation
of
the
parent,
concomitant
with
an
increase
in
triadimenol.
Hydrolysis
of
water­
soluble
radiocarbon
and
foliage
samples
from
cucumber
seedlings
released
triadimefon
and
triadimenol,
as
well
as
low
levels
of
KWG
1323
and
KWG
1342.
These
additional
metabolites
were
not
detected
in
the
tomato
seedlings.
Degradation
of
triadimefon
in
mature
cucumber
and
tomato
plants
appeared
to
be
similar
to
that
in
the
seedlings,
with
minor
differences.
The
fruit
and
foliage
differed
in
their
ability
to
metabolize
the
parent.
In
both
tomato
and
cucumber
fruit,
the
terminal
degradation
product
was
primarily
triadimenol,
while
the
foliage
of
both
tomato
and
cucumber
exhibited
a
more
complex
series
of
degradation
products.
In
tomato,
triadimefon
and
triadimenol
account
for
96.6%
total
radioactive
residue
(
TRR)
one
day
after
treatment,
88.1%
TRR
7
days
after
treatment,
83.8%
TRR
14
days
after
treatment,
80.0%
TRR
21
days
after
treatment,
and
75.7%
TRR
28
days
after
treatment.
Similar
results
were
reported
for
cucumber.
KWG
1732
was
not
identified
in
either
tomatoes
or
cucumbers.
Triadimefon
Summary
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
314742
13
of
44
Grape
(
MRID
42123403)

In
a
grape
metabolism
study,
mature
fruit
were
harvested
56
days
following
treatment
of
an
established
vine
with
[
phenyl­
14C]
triadimefon;
immature
fruit
were
harvested
at
various
earlier
intervals.
A
rapid
decline
in
total
radioactivity
was
observed,
due
to
the
volatility
of
triadimefon.
The
decline
in
the
quantity
of
parent
observed
was
accompanied
by
a
buildup
of
the
metabolite
triadimenol.
Triadimenol
accounted
for
55.6%
of
TRR
in
mature
grapes
while
triadimefon
was
only
detected
at
1.1%
TRR.
The
remainder
of
the
identified
radioactivity
was
comprised
of
KWG
1342
and
its
conjugates
(
15.5%
TRR),
triadimenol
conjugates
(
5.6%
TRR),
and
p­
chlorophenol
and
its
conjugates
(
6.2%
TRR).
KWG
1323
and
KWG
1732
were
not
identified
in
the
study.

Wheat
(
MRID
42853401)

Following
foliar
treatment
of
wheat
with
[
phenyl­
14C]
triadimefon
at
a
rate
of
236
g
ai/
A,
approximately
2x
the
maximum
registered
rate
for
wheat,
the
metabolite
KWG
1732
was
the
major
residue
identified
(
35%
TRR)
in
wheat
grain;
a
glucoside
of
KWG
1342
was
the
other
major
residue
identified
(
21%
TRR)
in
wheat
grain.
Additionally,
triadimefon
accounted
for
1%
TRR,
triadimenol
accounted
for
6%
TRR
and
its
glucoside
was
found
at
6%
TRR;
pchlorophenol
was
also
identified
at
5%
TRR.
In
wheat
forage,
triadimefon
was
found
at
31­
74%
TRR
and
triadimenol
was
found
at
12­
35%
TRR;
together
they
accounted
for
the
majority
of
residues
(
66­
86%
TRR);
p­
chlorophenol
and
its
glucoside
were
also
identified,
at
9­
16%
TRR.
In
wheat
straw,
triadimenol
and
its
conjugates
accounted
for
the
majority
of
the
radioactivity
at
53%
TRR
and
triadimefon
accounted
for
only
1%
TRR;
p­
chlorophenol
and
its
conjugates
and
KWG
1342
and
its
conjugates
were
also
identified,
at
21%
and
19%
TRR,
respectively.

The
HED
MARC
examined
the
results
of
these
studies
and
determined
that
the
residues
of
concern
in
plants
are
triadimefon,
triadimenol,
KWG
1323,
KWG
1342,
and,
in
cereal
grains,
triadimefon,
triadimenol,
KWG
1323,
KWG
1342,
and
KWG
1732
(
S.
Knizner,
HED
MARC
memorandum,
1/
3/
1994).
The
chemical
names
and
structures
of
these
compounds
are
presented
in
Table
3.

The
reregistration
requirements
for
plant
metabolism
have
been
fulfilled.
HED
has
revisited
the
MARC
decision
by
examining
all
the
available
metabolism
and
field
trial
data
and
determined
that
the
triadimefon
residues
of
concern
in/
on
apples,
grapes,
pears,
pineapples,
and
raspberries
for
tolerance
expression
are
triadimefon
and
triadimenol
and
for
risk
assessment
are
triadimefon,
triadimenol,
KWG
1323,
and
KWG
1342.
The
metabolism
study
conducted
with
triadimefon
applied
to
grapes
indicate
that
triadimenol
is
the
major
metabolite
identified
at
56%
along
with
KWG
1342
at
16%.
Triadimefon
accounted
for
1.1%
TRR.
The
available
field
trial
data
indicate
that
residues
of
triadimefon
and
triadimenol
are
likely
to
be
found
in/
on
apples,
grapes,
pears,
pineapples,
and
raspberries
and
will
be
good
indicators
of
misuse
for
tolerance
enforcement.
The
two
metabolites,
KWG
1323
and
KWG
1342
were
mostly
non­
quantifiable
as
indicated
from
the
field
trial
data
and
therefore
should
only
be
included
in
risk
assessment.

There
have
been
no
previous
triazole
labeled
studies
conducted
with
triadimefon
and
data
from
the
available
soil
metabolism
studies
conducted
with
triadimefon
indicate
that
soil
microbes
metabolize
the
triazole
fungicide
to
free
triazole,
which
may
be
taken
up
into
the
plant.
If
registration
on
additional
commodities
and
livestock
feed
items
are
requested,
then
triazole
and
Triadimefon
Summary
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
314742
14
of
44
phenyl­
labeled
plant
and
livestock
metabolism
studies
would
be
required.
Such
data
may,
in
turn,
trigger
the
need
for
magnitude
of
the
residue
studies
conducted
with
plants
and
livestock.

860.1300
Nature
of
the
Residue
­
Livestock
The
reregistration
requirements
for
livestock
metabolism
are
fulfilled
based
on
acceptable
goat
and
poultry
metabolism
studies.
For
the
ruminant
study,
a
lactating
goat
received
[
phenyl­
14C]
triadimefon
at
86.4
ppm
for
three
consecutive
days
in
feed.
The
feeding
level
corresponds
to
1728x
the
maximum
theoretical
dietary
burden
to
dairy
cattle
and
864x
the
maximum
theoretical
dietary
burden
to
beef
cattle
(
see
860.1480
Meat,
Milk,
Poultry,
and
Eggs).
The
parent
was
detected
at
low
levels
in
milk
and
fat
(<
5%
TRR)
but
was
not
detected
in
kidney,
liver,
or
muscle.
The
major
residue
identified
was
KWG
1342
glucuronide
(
6­
47%
TRR).
Triadimenol
and
its
conjugates
comprised
a
major
portion
of
the
residue
in
tissues
and
milk
(
totals
of
9­
42%
TRR).
The
remainder
of
the
radioactivity
was
identified
as
KWG
1323
glucuronide
(
19­
22%
TRR
in
muscle
and
fat)
and
KWG
1342
(
1­
6%
TRR)
and
its
sulfate
(
1­
15%
TRR
in
tissues,
43%
TRR
in
milk).

For
the
poultry
study,
16
laying
hens
received
[
phenyl­
14C]
triadimefon
at
28.7
ppm
for
three
consecutive
days
in
feed.
The
parent
was
identified
in
fat
and
eggs
(
4­
17%
TRR)
but
was
not
detected
in
liver
or
muscle.
Triadimenol
and
its
related
compounds
were
the
major
metabolites
identified
(
totals
of
41­
49%
TRR).
The
remainder
of
the
radioactivity
was
identified
as
KWG
1342
and
its
related
compounds
(
totals
of
10­
36%
TRR),
p­
chlorophenol
(
liver
and
fat
only
at
2­
4%
TRR),
chlorophenoxytriazolyl
acetic
acid
(
muscle
only
at
3%
TRR),
and
KWG
1323
(
fat
and
eggs
only
at
3­
5%
TRR).
Currently,
the
basic
producer
(
Bayer)
does
not
have
any
registered
uses
of
triadimefon
on
poultry
feed
items.

HED
has
determined
that
the
residues
of
concern
for
tolerance
expression
and
risk
assessment
in
livestock
are
triadimefon,
triadimenol,
KWG
1323,
and
KWG
1342.
The
chemical
names
and
structures
of
these
compounds
are
presented
in
Table
3.

860.1340
Residue
Analytical
Methods
­
Plants
The
Pesticide
Analytical
Manual
(
PAM)
Vol.
II
lists
two
GC/
MS
methods
(
Methods
I
and
II)
for
the
determination
of
triadimefon
and
its
free
and
conjugated
metabolites
in
plant
commodities.
Both
methods
are
common
moiety
methods.
In
Method
I
(
Report
No.
69531),
residues
are
extracted
using
methanol
or
methanol:
acetone
(
2:
1,
v:
v).
Following
cleanup
on
an
ion­
exchange
column,
the
total
residues
are
hydrolyzed
to
p­
chlorophenol
using
concentrated
HCl.
p­
Chlorophenol
is
isolated
by
steam
distillation
followed
by
acid/
base
partitioning
and
then
derivatized
with
dinitrofluorobenzene
for
determination
by
GC/
MS
using
selected
ion
monitoring.
Residues
are
expressed
in
triadimefon
equivalents.
Method
II
(
Report
No.
80265)
is
similar
to
Method
I.
The
reported
LOQ
is
0.05
and
LOD
is
0.01
ppm
for
both
methods.

A
GC/
NPD
method
(
Report
No.
80488)
is
available
for
determination
of
residues
of
triadimefon,
triadimenol,
KWG
1342,
and
KWG
1323
and
is
adequate
for
the
enforcement
of
apple,
grape,
pear,
pineapple,
and
raspberry
tolerances.
Briefly,
residues
are
extracted
under
reflux
in
methanol:
water
(
7:
3,
v:
v)
and
the
extract
is
buffered
and
hydrolyzed
in
cellulase
at
37
°
C
overnight
to
release
conjugated
residues.
Residues
are
partitioned
into
dichloromethane:
acetonitrile
(
2:
1,
Triadimefon
Summary
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
314742
15
of
44
v:
v),
cleaned
up
by
gel
permeation
chromatography,
and
separated
into
parent
(
triadimefon
and
triadimenol)
and
metabolite
(
KWG
1342
and
KWG
1323)
fractions
by
semi­
preparative
HPLC.
The
metabolite
fraction
residues
are
derivatized
with
trifluoroacetic
anhydride
and
all
residues
are
determined
using
GC/
NPD.
The
reported
LOQ
for
apples,
cucurbits,
grapes,
pears,
and
pineapple
is
0.01
ppm
for
triadimefon,
triadimenol,
KWG
1342,
and
KWG
1323.
The
LOD
was
not
reported.

The
registrant
has
proposed
a
GC/
MS
method
(
Report
No.
106549)
for
enforcement
of
tolerances
for
residues
of
triadimefon,
triadimenol,
KWG
1342,
KWG
1323,
and
KWG
1732
in
plant
commodities.
Briefly,
residues
are
extracted
under
reflux
in
methanol:
water,
hydrolyzed
with
cellulase
at
37
°
C
overnight,
and
partitioned
with
dichloromethane:
acetonitrile.
The
aqueous
phase,
containing
KWG
1732,
is
partitioned
with
acidic
ethyl
acetate,
and
methylated
with
trimethylsilyl
diazomethane
for
analysis
by
GC/
MS.
The
dichloromethane
phase
is
cleaned
up
by
gel
permeation
chromatography
and
separated
by
semi­
preparative
HPLC
into
two
fractions:
one
containing
triadimefon
and
triadimenol
and
the
other
containing
KWG
1323
and
KWG
1342.
Triadimefon
and
triadimenol
are
determined
directly
by
GC/
MS;
KWG
1323
and
KWG
1342
are
derivatized
prior
to
GC/
MS
analysis.
The
method
has
been
successfully
radiovalidated
and
has
undergone
independent
laboratory
validation.
The
reported
method
LOQ
is
0.05
ppm
for
triadimefon,
triadimenol,
KWG
1342,
KWG
1323,
and
KWG
1732
in
wheat
grain.
The
LOD
was
not
reported.

860.1340
Residue
Analytical
Methods
­
Livestock
The
Pesticide
Analytical
Manual
(
PAM)
Vol.
II
lists
the
two
GC/
MS
methods
described
above
(
Methods
I
and
II)
for
the
determination
of
triadimefon
and
its
free
and
conjugated
metabolites
in
livestock
commodities.
Method
I
(
Report
No.
69531)
is
appropriate
for
livestock
tissues
and
milk
and
Method
II
(
Report
No.
80265)
is
appropriate
for
livestock
tissues
and
eggs.
The
reported
LOQ
is
0.05
and
LOD
is
0.01
ppm
for
both
methods.

860.1360
Multiresidue
Methods
The
reregistration
requirements
for
multiresidue
method
testing
for
residues
of
triadimefon
and
its
metabolites
are
satisfied.
The
10/
99
FDA
PESTDATA
database
(
PAM
Volume
I,
Appendix
I)
indicates
that
triadimefon
is
completely
recovered
(>
80%)
using
Multiresidue
Methods
Section
302
(
Luke
Method;
Protocol
D);
recovery
of
triadimefon
is
small
(<
50%)
using
Multiresidue
Methods
Sections
303
(
Mills,
Onley,
and
Gaither;
Protocol
E,
nonfatty)
and
304
(
Mills,
fatty
food).
Triadimefon
metabolites
triadimenol
and
KWG
1323
are
completely
recovered
using
Section
302.
Triadimenol,
KWG
1323,
and
KWG
1732
are
not
recovered
using
Sections
303
and
304.
Although
multiresidue
method
testing
data
have
been
submitted
for
KWG
1342,
the
PESTDATA
database
does
not
contain
any
recovery
data
for
this
metabolite.

860.1380
Storage
Stability
Data
The
reregistration
requirements
for
storage
stability
data
are
satisfied.
Adequate
storage
stability
data
for
plant
and
livestock
commodities
have
been
submitted
and
evaluated.

Plant
commodities:
The
available
storage
stability
data
indicate
that
residues
of
triadimefon
and
Triadimefon
Summary
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
314742
16
of
44
its
metabolites
triadimenol,
KWG
1342,
and
KWG
1323
are
stable
for
up
to
24
months
of
frozen
storage
(
ca.
­
20
°
C)
in/
on
the
following
commodities:
apple;
cucumber;
grapes,
grape
juice,
and
raisins;
pineapple;
sugar
beet
roots,
tops,
and
molasses;
tomatoes;
and
wheat
grain
and
forage.
These
analytes
are
also
stable
in
grape
pomace
(
wet
and
dry)
for
up
to
6
months.
Residues
of
triadimefon
and
KWG
1323
are
stable
in
asparagus
and
wheat
straw,
bran,
flour
and
grain
dust
up
to
24
months
of
frozen
storage,
and
residues
of
triadimefon,
triadimenol,
and
KWG
1323
are
stable
in
coffee
beans
up
to
6
months
of
frozen
storage.
When
corrected
for
concurrent
method
recoveries,
residues
of
triadimenol
appear
to
decline
after
24
months
in
the
following
crop
matrices:
asparagus
(
18%),
wheat
straw
(
30%),
bran
(
29%),
flour
(
25%),
and
grain
dust
(
17%).
Residues
of
KWG
1342
also
appeared
to
decline
in
asparagus
(
15%)
and
wheat
bran
(
20%)
after
24
months
of
frozen
storage,
and
in
coffee
beans
(
79%)
after
40
days
of
storage.

Storage
stability
data
indicate
that
KWG
1732
is
stable
in
wheat
grain
stored
frozen
at
approximately
­
20
°
C
for
up
to
2.5
years.

Livestock
commodities:
The
available
storage
stability
data,
collected
using
samples
from
the
livestock
metabolism
studies,
indicate
that
residues
of
triadimefon
and
its
regulated
metabolites
are
stable
in
goat
milk,
fat,
and
liver
approximately
14,
26,
and
29
months,
respectively,
of
frozen
storage.
Residues
were
found
to
be
stable
in
poultry
muscle
and
eggs
approximately
15
months
of
frozen
storage.
These
data
are
adequate
to
validate
the
storage
intervals
of
livestock
commodity
samples
collected
from
the
feeding
studies.

860.1400
Water,
Fish,
and
Irrigated
Crops
Triadimefon
is
not
registered
for
direct
use
on
water
and
aquatic
food
and
feed
crops.
Therefore,
no
residue
chemistry
data
are
required
under
these
guideline
topics.

860.1460
Food
Handling
Triadimefon
is
not
registered
for
use
in
food­
handling
establishments;
therefore,
no
residue
chemistry
data
are
required
under
this
guideline
topic.

860.1480
Meat,
Milk,
Poultry,
and
Eggs
The
reregistration
requirements
for
data
depicting
the
magnitude
of
triadimefon
residues
of
concern
in
meat,
milk,
poultry,
and
eggs
have
been
fulfilled.
Acceptable
ruminant
and
poultry
feeding
studies
have
been
submitted
and
evaluated.
In
these
studies,
livestock
were
fed
a
1:
1
mixture
of
triadimefon
and
triadimenol.
Samples
were
analyzed
for
bound
and
free
residues
of
triadimefon,
triadimenol,
KWG
1342,
and
KWG
1323.

The
theoretical
dietary
burden
(
TDB)
to
cattle
is
presented
below
in
Table
6.
Currently,
the
basic
producer,
Bayer,
has
no
registered
uses
of
triadimefon
on
any
poultry
or
swine
feed
items.
Therefore,
no
tolerances
for
poultry
or
swine
commodities
are
required.

Table
6.
Calculation
of
Dietary
Burdens
of
Triadimefon
to
Livestock.

Feed
Commodity
%
Dry
Matter1
%
Diet1
Reassessed
Tolerance
(
ppm)
2
Dietary
Contribution
(
ppm)
3
Triadimefon
Summary
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
314742
Table
6.
Calculation
of
Dietary
Burdens
of
Triadimefon
to
Livestock.

17
of
44
Beef
Cattle
Alfalfa,
hay
89
45
No
tolerance
N/
A
Apple,
wet
pomace
40
20
0.2
0.10
Corn,
field,
grain
88
20
No
tolerance
N/
A
Soybean,
meal
92
15
No
tolerance
N/
A
TOTAL
BURDEN
N/
A4
100
N/
A
0.10
Dairy
Cattle
Alfalfa,
hay
89
45
No
tolerance
N/
A
Apple,
wet
pomace
40
10
0.2
0.05
Corn,
field,
grain
88
30
No
tolerance
N/
A
Soybean,
meal
92
15
No
tolerance
N/
A
TOTAL
BURDEN
N/
A
100
N/
A
0.05
1.
OPPTS
Guideline
860.1200,
Table
1
(
August
1996).
2.
Reassessed
tolerances
from
Table
14.
3.
Contribution
=
(%
diet
/
%
dry
matter)
x
(
reassessed
tolerance).
4.
N/
A
=
Not
applicable.

Ruminant.
In
the
ruminant
feeding
study,
cattle
were
fed
triadimenol:
triadimefon
(
1:
1)
at
total
dose
levels
of
25,
75,
and
250
ppm.
The
resulting
triadimefon
dose
levels
of
12.5,
37.5,
and
125
ppm
represent
125x,
375x,
and
1250x
the
theoretical
dietary
burden
to
beef
cattle,
and
250x,
750x,
and
2500x
the
TDB
to
dairy
cattle.
The
results
of
the
study
are
summarized
in
Table
7.

Table
7.
Estimation
of
Potential
Triadimefon,
Triadimenol,
KWG
1342,
and
KWG
1323
Residues
in
Milk
and
Tissues
of
Beef
and
Dairy
Cows
Using
Data
from
the
Ruminant
Feeding
Study.

Matrix
25
ppm
feeding
level
(
12.5
ppm
triadimefon)
1
Estimated
residues
at
1x
TDB
using
25
ppm
feeding
level2
75
ppm
feeding
level
(
37.5
ppm
triadimefon)
1
Estimated
residues
at
1x
TDB
using
75
ppm
feeding
level2
250
ppm
feeding
level
(
125
ppm
triadimefon)
1
Estimated
residues
at
1x
TDB
using
250
ppm
feeding
level2
Milk
0.014
(
0.007)
0.000028
0.035
(
0.018)
0.000024
0.076
(
0.038)
0.000015
Muscle
<
0.01
0.000040
0.019
(
0.009)
0.000024
0.043
(
0.022)
0.000018
Kidney
0.412
(
0.206)
0.0016
0.787
(
0.394)
0.0011
2.27
(
1.14)
0.00091
Liver
0.093
(
0.047)
0.00038
0.287
(
0.144)
0.00038
1.00
(
0.50)
0.00040
Fat
0.024
(
0.012)
0.000096
0.086
(
0.043)
0.00011
0.211
(
0.106)
0.000085
1.
Numbers
in
parentheses
refer
to
triadimefon
residue
levels
and
were
used
to
calculate
the
estimated
residues
at
1x
TDB.
It
is
assumed
that
one­
half
of
the
total
residues
found
is
due
to
triadimefon.
2.
Estimated
triadimefon
residues
=
(
total
dietary
contribution,
Table
6
/
feeding
level)
x
(
residue
from
feeding
studies;
residues
reported
at
less
than
the
LOD
of
0.01,
half
the
LOD
was
used).
Whole
milk
was
calculated
using
TDB
from
dairy
cattle.
Muscle,
fat,
liver,
and
kidney
were
calculated
using
TDB
from
beef
cattle.

The
maximum
residue
of
triadimefon
observed
in
any
matrix
in
the
ruminant
feeding
study
was
kidney
at
0.412
ppm
after
dosing
at
an
exaggerated
feeding
level
of
25
ppm
(
12.5
ppm
triadimefon)
or
125x
the
beef
cattle
dietary
burden.
Based
on
the
125x
dosing
level
for
beef
cattle,
the
maximum
expected
residues
of
triadimefon
in
kidney
at
a
1x
level
are
0.0016
ppm,
which
is
less
than
the
livestock
method
LOD
of
0.01
ppm.

Triadimefon
is
not
registered
for
use
as
a
direct
livestock
treatment.
The
nature
of
the
residue
in
Triadimefon
Summary
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
314742
18
of
44
livestock
is
adequately
defined
for
the
current
uses.
HED
concludes
that
the
supported
registered
uses
on
apples,
grapes,
pears,
pineapples,
and
raspberries
result
in
a
40
CFR
§
180.6(
a)(
3)
situation
for
livestock
commodities;
i.
e.,
there
is
no
reasonable
expectation
of
finite
residues
in
livestock
commodities.
Therefore,
additional
data
on
the
transfer
of
residues
to
meat,
milk,
poultry,
and
eggs
are
not
required
and
all
tolerances
for
livestock
commodities
should
be
revoked.

860.1500
Crop
Field
Trials
The
reregistration
requirements
for
magnitude
of
the
residue
in/
on
the
following
RACs
based
on
the
currently
registered
use
patterns
are
fulfilled
pending
label
revisions
and/
or
tolerance
adjustments:
apples,
grapes,
pears,
pineapple,
and
raspberries.

Use
of
triadimefon
on
cucurbits
are
no
longer
being
supported
by
bayer,
and
therefore,
must
be
removed
from
all
triadimefon
product
labels.

Apple
(
MRID
42342303)

A
tolerance
of
1.0
ppm
has
been
established
for
the
combined
residues
of
triadimefon
and
its
metabolites
containing
chlorophenoxy
and
triazole
moieties
(
expressed
as
parent)
in/
on
apples
[
40
CFR
§
180.410(
a)].

The
registrant
cited
previously
submitted
residue
data
(
1977­
1980;
MRIDs
00025544,
00025715,
and
00063831)
for
apples
and
processed
fractions,
which
reflect
a
zero­
day
PHI
and
support
the
current
tolerance
of
1.0
ppm.
The
registrant
has
submitted
data
(
1992;
MRID
42342303)
to
reflect
a
45­
day
PHI
for
triadimefon
use
on
apples.
A
total
of
ten
trials
were
conducted
in
Region
1
(
two
trials;
NY
and
PA
at
a
total
of
0.75
lb
ai/
A
for
both
sites),
Region
2
(
one
trial;
NC
at
0.75
lb
ai/
A),
Region
5
(
three
trials;
IN
at
0.47
lb
ai/
A,
KS
at
0.41
lb
ai/
A,
and
MI
at
0.56
lb
ai/
A),
Region
10
(
two
trials;
Fresno,
CA
at
0.47
lb
ai/
A
and
Walnut
Grove,
CA
at
0.75
lb
ai/
A),
and
Region
11
(
two
trials;
Selah,
WA
at
0.075
lb
ai/
A
and
Wenatchee,
WA
at
1.5
lbs
ai/
A).
The
geographical
representation
is
considered
adequate
for
reregistration.
Samples
were
harvested
at
35­
46
days
following
the
last
of
three
foliar
spray
applications
of
the
50%
DF
formulation
using
ground
equipment.
Samples
were
stored
at
#­
10
°
C
for
up
to
212
days
prior
to
analysis
using
Method
80488.
Residues
found
in/
on
treated
samples
are
summarized
in
Table
8;
the
combined
residues
of
triadimefon
and
the
three
measured
metabolites
(
triadimenol,
KWG
1342,
and
KWG
1323)
were
#
0.09
ppm
in/
on
all
treated
samples.

These
data
indicate
that
the
established
tolerance
for
apples
is
too
high
based
on
a
45­
day
PHI,
and
that
the
combined
residues
of
parent
and
metabolites
are
not
likely
to
exceed
0.2
ppm
in/
on
apples
following
application
at
the
maximum
registered
rate
of
0.75
lb
ai/
A
with
a
45­
day
PHI.

Grapes
(
MRID
41809401)

A
tolerance
of
1.0
ppm
has
been
established
for
the
combined
residues
of
triadimefon
and
its
metabolites
containing
chlorophenoxy
and
triazole
moieties
(
expressed
as
parent)
in/
on
grapes
[
40
CFR
§
180.410(
a)].

The
registrant
has
submitted
data
(
1991;
MRID
41809401)
for
grapes,
which
indicate
that
the
Triadimefon
Summary
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
314742
19
of
44
combined
residues
of
triadimefon,
triadimenol,
KWG
1342,
and
KWG
1323
are
not
likely
to
exceed
the
established
tolerance
of
1.0
ppm
following
a
total
application
rate
of
0.56
lb
ai/
A
and
a
14­
day
PHI.
A
total
of
seven
trials
were
conducted
in
Region
1
(
one
trial,
NY),
Region
5
(
one
trial,
MI),
Region
10
(
three
trials,
CA),
and
Region
11
(
two
trials,
OR
and
WA).
The
geographical
representation
is
considered
adequate
for
reregistration.
Samples
were
harvested
at
0,
7,
14,
21,
and
28
days
following
the
last
of
four
foliar
spray
applications
of
the
50%
DF
formulation
at
0.19
lb
ai/
A/
application
using
ground
equipment.
A
total
of
0.75
lb
ai/
A
was
applied
in
four
treatments
made
at
14­
day
intervals.
Samples
were
stored
at
#­
10
°
C
for
up
to
406
days
prior
to
analysis
using
Method
80488.
Residues
found
in/
on
treated
samples
are
summarized
in
Table
8;
the
combined
residues
of
triadimefon
and
the
measured
metabolites
were
#
0.62
ppm
in/
on
all
treated
samples.

These
data
indicate
that
the
combined
residues
of
parent
and
metabolites
are
not
likely
to
exceed
the
established
tolerance
of
1.0
ppm
in/
on
grapes
following
application
at
the
maximum
registered
rate
of
0.56
lb
ai/
A
with
a
14­
day
PHI.

Pear
(
MRID
42342306)

A
tolerance
of
1.0
ppm
has
been
established
for
the
combined
residues
of
triadimefon
and
its
metabolites
containing
chlorophenoxy
and
triazole
moieties
(
expressed
as
parent)
in/
on
pears
[
40
CFR
§
180.410(
a)].

The
registrant
cited
previously
submitted
residue
data
(
MRID
00093967)
for
pears,
which
reflects
a
zero­
day
PHI
and
support
the
current
tolerance
of
1.0
ppm.
The
registrant
has
submitted
data
(
1992;
MRID
42342306)
to
reflect
a
45­
day
PHI
for
triadimefon
use
on
pears.
A
total
of
six
trials
were
conducted
in
Region
1
(
one
trial,
NY
at
a
total
of
0.75
lb
ai/
A),
Region
5
(
one
trial,
MI
at
0.56
lb
ai/
A),
Region
10
(
two
trials,
Clarksburg,
CA
at
1.2
lbs
ai/
A
and
Hollister,
CA
at
0.75
lb
ai/
A),
and
Region
11
(
two
trials,
OR
at
0.75
lb
ai/
A
and
WA
at
0.47
lb
ai/
A).
The
geographical
representation
is
considered
adequate
for
reregistration.
Samples
were
harvested
at
45­
46
days
following
the
last
of
three
foliar
spray
applications
of
the
50%
DF
formulation
using
ground
equipment.
Samples
were
stored
at
#­
10
°
C
for
up
to
230
days
prior
to
analysis
using
Method
80488.
Residues
found
in/
on
treated
samples
are
summarized
in
Table
8;
the
combined
residues
of
triadimefon
and
the
three
measured
metabolites
were
#
0.08
ppm
in/
on
all
treated
samples.

These
data
indicate
that
the
established
tolerance
of
1.0
ppm
for
pears
is
to
high
based
on
a
45­
day
PHI,
and
that
the
combined
residues
of
parent
and
metabolites
in/
on
pears
are
not
likely
to
exceed
0.20
ppm
following
application
at
the
maximum
registered
rate
of
0.75
lb
ai/
A
with
a
45­
day
PHI.

Pineapple
(
MRID
42342307)

A
tolerance
of
3.0
ppm
has
been
established
for
the
combined
residues
of
triadimefon
and
its
metabolites
containing
chlorophenoxy
and
triazole
moieties
(
expressed
as
parent)
in/
on
pears
[
40
CFR
§
180.410(
a)].

The
50%
DF
formulation
may
be
applied
to
fresh
pineapple
as
a
postharvest
dip
or
spray
at
0.28
lb
ai/
100
gal.
The
fruit
should
be
thoroughly
covered
and
allowed
to
drain.
Dipping
time
is
Triadimefon
Summary
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
314742
20
of
44
limited
to
a
maximum
of
three
minutes.
The
registrant
submitted
data
(
1992;
MRID
42342307)
for
pineapples
harvested
from
two
test
sites
in
HI,
depicting
the
magnitude
of
residues
of
triadimefon
and
its
metabolites
triadimenol,
KWG
1323,
and
KWG
1323
in/
on
fresh
pulp
and
peel
(
with
totals
calculated
for
whole
fruit
based
on
the
percentage
weight
of
pulp
and
peel
for
each
sample).
The
geographical
representation
is
considered
adequate
for
reregistration.
Fresh
whole
pineapples
received
a
postharvest
dip
treatment
in
a
1­
gal
or
7.5­
gal
solution
containing
the
50%
DF
formulation
at
0.42
lb
ai/
100
gal.
The
dip
solution
for
both
treated
and
untreated
fruit
also
contained
FMC
Sta­
Fresh
7055
wax.
Five
samples
from
each
of
the
two
sites
were
dipped,
one
sample
from
each
site
per
day
over
five
consecutive
days
(
to
approximate
operator
variation).
It
was
not
clear
whether
the
dipping
solutions
were
newly
prepared
each
day
or
prepared
once
and
then
reused
for
subsequent
dips.
This
is
a
deficiency
and
the
registrant
must
state
if
dipping
solutions
were
prepared
fresh
each
day
or
prepared
once
and
reused.
If
dipping
solutions
were
reused,
the
registrant
must
either
demonstrate
the
integrity
of
the
dip
solutions
under
these
conditions,
or
perform
a
new
study.

Eight
samples
were
dipped
for
three
minutes
each,
and
two
samples
were
dipped
for
thirty
seconds
each.
Samples
were
frozen
after
dipping,
and
were
stored
at
#­
10
°
C
for
up
to
239
days
prior
to
analysis
using
Method
80488.
Residues
found
in/
on
treated
samples
are
summarized
in
Table
8;
the
combined
residues
of
triadimefon
and
the
three
measured
metabolites
were
#
0.18
ppm
in/
on
treated
pulp,
were
#
8.10
ppm
in/
on
treated
peel,
and
were
calculated
to
be
#
1.82
ppm
in/
on
the
whole
fruit.

These
data
indicate
that
the
established
tolerance
of
3.0
ppm
for
pineapples
is
too
high,
and
that
the
combined
residues
of
parent
and
metabolites
in/
on
are
not
likely
to
exceed
2.0
ppm
in/
on
fresh
pineapple
following
a
three
minute
postharvest
dip
in
solution
containing
the
50%
DF
formulation
at
the
maximum
registered
rate
of
0.28
lb
ai/
100
gal
solution.

Raspberry
(
MRID
92188061)

A
tolerance
of
2.0
ppm
with
a
regional
registration
restricted
to
California
has
been
established
for
the
combined
residues
of
triadimefon
and
its
metabolites
containing
chlorophenoxy
and
triazole
moieties
(
expressed
as
parent)
in/
on
raspberries
[
40
CFR
§
180.410(
c)].

The
registrant
has
submitted
data
(
1990;
MRID
92188061)
for
raspberries,
which
indicate
that
the
combined
residues
of
triadimefon,
triadimenol,
KWG
1342,
and
KWG
1323
are
not
likely
to
exceed
the
established
tolerance
of
2.0
ppm
following
a
total
application
rate
of
0.88
lb
ai/
A
and
a
1­
day
PHI.
A
total
of
fifteen
trials
were
conducted
in
Region
10
(
CA).
The
geographical
representation
is
considered
adequate
for
reregistration.
Samples
were
harvested
at
0,
1,
2,
and
3
days
following
the
last
of
seven
foliar
spray
applications
of
the
50%
WP
formulation
at
0.13
lb
ai/
A/
application
(
9
samples),
0.19
lb
ai/
A/
application
(
2
samples),
and
0.25
lb
ai/
A/
application
(
5
samples).
A
total
of
0.88
lb
ai/
A,
1.3
lbs
ai/
A,
or
1.8
lbs
ai/
A
was
applied
in
seven
treatments
made
at
12
to
15­
day
intervals.
All
applications
were
applied
in
200
gallons
of
water
per
acre.
Samples
were
stored
at
#­
20
°
C
prior
to
analysis
using
Method
54166.
Residues
found
in/
on
treated
samples
are
summarized
in
Table
8.
The
maximum
residues
found
when
triadimefon
was
applied
at
the
maximum
use
rate
of
0.88
lb
ai/
A
with
a
1­
day
PHI
were
1.58
ppm.

Analysis
for
residues
of
the
metabolites
KWG­
1323
and
KWG­
1342
are
not
considered
necessary
Triadimefon
Summary
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
314742
21
of
44
to
support
the
tolerance.
Residue
studies
show
that
the
metabolites
KWG­
1323
and
KWG­
1342
represent
a
negligible
amount
of
the
total
residues
on
other
crops
such
as
grapes.
The
negligible
quantities
of
the
metabolites
along
with
triadimefon
and
triadimenol
would
not
likely
exceed
the
established
tolerance.

These
data
indicate
that
the
combined
residues
of
parent
and
metabolites
are
not
likely
to
exceed
the
established
tolerance
of
2.0
ppm
in/
on
raspberries
following
application
at
the
maximum
registered
rate
of
0.88
lb
ai/
A
with
a
1­
day
PHI.

Table
8.
Summary
of
Residues
from
the
Crop
Field
Trials
with
Triadimefon.

Crop
Matrix
(
number
of
samples)
Total
Applic.
Rate
in
lb
ai/
A
PHI
(
days)
Residues
(
ppm)
1
Triadimefon
Triadimenol
KWG
1342
KWG
1323
Total
Residue2
Apple
(
registered
use
=
0.75
lb
ai/
A
total
application
rate,
45­
day
PHI)
5
Whole
fruit
(
1)
0.41
(
0.55x)
45
<
0.01
<
0.01
<
0.01
<
0.01
0.04
Whole
fruit
(
2)
0.47
(
0.63x)
45
<
0.01
<
0.01­
0.02
<
0.01
<
0.01
0.04­
0.05
Whole
fruit
(
1)
0.56
(
0.75x)
46
<
0.01
0.02
<
0.01
<
0.01
0.05
Whole
fruit
(
5)
0.75
(
1x)
38­
46
<
0.01­
0.02
0.01­
0.05
<
0.01
<
0.01­
0.01
0.04­
0.09
Grape
(
registerd
use
=
0.56
lb
ai/
A
total
application
rate,
14­
day
PHI)

Whole
fruit
(
7)
0.75
(
1.3x)
0,
7,
14,
21,
and
28
0.02­
0.29
<
0.01­
0.45
<
0.01­
0.02
<
0.01­
0.03
0.05­
0.62
Pear
(
registered
use
=
0.75
lb
ai/
A
total
application
rate,
45­
day
PHI)

Whole
fruit
(
1)
0.47
(
0.63x)
45
<
0.01
<
0.01
<
0.01
<
0.01
0.04
Whole
fruit
(
1)
0.56
(
0.75x)
45
<
0.01
<
0.01
<
0.01
<
0.01
0.04
Whole
fruit
(
3)
0.75
(
1x)
45­
46
<
0.01­
0.03
0.02­
0.03
<
0.01­
0.02
<
0.01
0.06­
0.08
Whole
fruit
(
1)
1.2
(
1.6x)
45
<
0.01
<
0.01
<
0.01
<
0.01
0.04
Pineapple
(
registered
use
=
0.28
lb
ai/
100
gal
total
postharvest
dip
or
spray)

Peel
(
10)
0.42
lb
ai/
100
gal
(
1.48x)
N/
A3
4.46­
7.59
0.24­
0.49
<
0.01
<
0.01
4.78­
8.10
Pulp
(
10)
0.42
lb
ai/
100
gal
(
1.48x)
N/
A
0.06­
0.15
<
0.01­
0.01
<
0.01
<
0.01
0.09­
0.18
Whole
fruit
(
10)
0.42
lb
ai/
100
gal
(
1.48x)
N/
A
NC4
NC
NC
NC
0.82­
1.82
Raspberry
(
registered
use
=
0.88
lb
ai/
A
total
application
rate,
1­
day
PHI)

Whole
fruit
(
2)
0.88
(
1x)
0
1.50­
1.64
0.330­
0.371
NS6
NS
1.83­
2.01
Whole
fruit
(
2)
0.88
(
1x)
1
1.04­
1.14
0.443­
0.454
NS
NS
1.49­
1.58
Whole
fruit
(
2)
0.88
(
1x)
2
0.665­
0.750
0.433­
0.495
NS
NS
1.10­
1.25
Whole
fruit
(
1)
0.88
(
1x)
2
1.01
0.630
NS
NS
1.64
Whole
fruit
(
2)
0.88
(
1x)
3
0.286­
0.348
0.490­
0.495
NS
NS
0.78­
0.84
Whole
fruit
(
2)
1.3
(
1.5x)
3
0.298­
0.448
0.382­
0.535
NS
NS
0.68­
0.98
Whole
fruit
(
2)
1.8
(
2x)
0
1.75­
2.17
0.433­
0.705
NS
NS
2.46­
2.60
Whole
fruit
(
2)
1.8
(
2x)
1
1.07­
1.27
0.555­
0.565
NS
NS
1.63­
1.84
Whole
fruit
(
1)
1.8
(
2x)
2
0.78
0.665
NS
NS
1.45
1.
Values
corrected
for
apparent
residues
found
in/
on
control
samples
and
for
concurrent
method
recoveries.
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2.
Calculated
to
include
values
<
0.01
ppm
as
0.01
ppm.
3.
N/
A
=
Not
applicable.
4.
NC
=
Not
calculated.
5.
10
trials
were
conducted,
however,
the
Selah,
WA
trial
conducted
at
0.075
lb
ai/
A
was
excluded
due
to
the
low
application
rate.
6.
NS
=
Not
sampled.

The
available
crop
field
trials
reflecting
use
of
registered
formulations
at
1x
the
maximum
label
rate
showed
finite
residues
of
triadimefon
and
its
metabolites
triadimenol,
KWG
1342,
and
KWG
1323
in/
on
the
RACs
of
all
crops
for
which
registration
exists.
Overall,
adequate
field
trial
data
depicting
triadimefon
residues
of
concern
following
treatments
according
to
the
maximum
registered
use
patterns
of
the
representative
formulations
that
are
being
supported
have
been
submitted
for
the
RACs
listed
above.
Details
of
any
required
label
amendments
are
presented
in
860.1200
Directions
for
Use.
Refer
to
the
"
Tolerance
Reassessment
Summary"
section
for
recommendations
with
respect
to
established
tolerance
levels.

860.1520
Processed
Food
and
Feed
The
reregistration
requirements
for
magnitude
of
the
residue
in
the
processed
commodities
of
the
following
crops
have
been
fulfilled:
apples,
grapes,
and
pineapple.
The
available
data
indicate
that
residues
do
not
concentrate
significantly
in
apple
juice
(
reduction
factor
of
0.6x),
grape
juice,
and
pineapple
juice.
The
available
data
indicate
that
residues
of
triadimefon
and
its
metabolites
concentrate
1.6x
in
apple
wet
pomace
and
4x
in
raisins;
refer
to
"
Tolerance
Reassessment
Summary"
section
for
recommendations
with
respect
to
the
need
for
tolerances
as
a
result
of
concentration
of
residues
in
these
processed
commodities.
The
available
data
also
indicate
that
triadimefon
residues
of
concern
concentrate
10x
in
apple
dry
pomace,
3x
in
grape
wet
pomace,
5x
in
grape
dry
pomace,
7x
in
raisin
waste,
and
1.3x
in
pineapple
process
residue
(
pineapple
bran);
no
tolerances
are
required
for
these
commodities
as
they
are
no
longer
considered
significant
livestock
feed
items.

Processing
data
for
sugar
beets
and
wheat
have
been
submitted
and
reviewed;
however,
Bayer
is
no
longer
supporting
use
of
triadimefon
on
these
crops.

860.1650
Submittal
of
Analytical
Reference
Standards
An
analytical
reference
standard
for
triadimefon
was
submitted
by
Bayer
CropScience
in
October
of
2002
and
expires
August
of
2013.
The
standard
is
available
at
the
EPA
National
Pesticide
Standards
Repository.

860.1850
Confined
Accumulation
in
Rotational
Crops
The
reregistration
requirements
for
confined
rotational
crops
are
fulfilled.
Because
triadimefon
and
its
regulated
metabolites
were
identified
at
>
0.01
ppm
in
various
rotational
crops
at
various
intervals,
limited
and/
or
field
rotational
crop
studies
were
required.
However,
the
registrant
has
since
requested
removal
of
all
rotatable
crop
uses
from
product
labels.

860.1900
Field
Accumulation
in
Rotational
Crops
Studies
for
field
accumulation
in
rotational
crops
have
not
been
submitted.
The
registrant
has
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requested
removal
of
all
rotatable
crop
uses
from
product
labels.
Trials
for
field
accumulation
in
rotational
crops
are
not
required
at
this
time.
However,
if
the
registrant
wishes
to
allow
rotation
in
the
future,
field
accumulation
studies
will
be
needed
to
set
tolerance
levels
for
rotational
crops.

Tolerance
Reassessment
Summary
Tolerances
for
residues
in/
on
plant
and
livestock
commodities
have
been
established
under
40
CFR
§
180.410.
The
tolerances
are
expressed
in
terms
of
residues
of
triadimefon
[
1­(
4­
chlorophenoxy)­
3,3­
dimethyl­
1­(
1H­
1,2,4­
triazol­
1­
yl)­
2­
butanone]
and
its
metabolites
containing
chlorophenoxy
and
triazole
moieties
(
expressed
as
the
parent
compound).
The
qualitative
nature
of
the
residue
in
plants
and
livestock
is
adequately
understood.
HED
has
determined
that
the
triadimefon
residues
of
concern
in/
on
apples,
grapes,
pears,
pineapples,
and
raspberries
for
tolerance
expression
are
triadimefon
and
triadimenol.
The
reorganization
of
triadimefon
tolerances
and
tolerance
expression
for
all
RACs
should
be
conducted
as
depicted
below
in
Table
9.
A
summary
of
triadimefon
tolerance
reassessments
is
presented
in
Table
10.

Table
9.
Reorganization
of
Triadimefon
Tolerances
Required
Under
40
CFR.

40
CFR
Section
Reserved
For
Tolerance
Expression
§
180.410(
a)
apple,
grape,
pear,
and
pineapple
Tolerances
are
established
for
the
combined
residues
of
the
fungicide
1­(
4­
chlorophenoxy)­
3,3­
dimethyl­
1­(
1H­
1,2,4­
triazol­
1­
yl)­
2­
butanone
[
triadimefon]
and
$­(
4­
chlorophenoxy)­"­(
1,1­
dimethylethyl)­
1H­
1,2,4­
triazole­
1­
ethanol
[
triadimenol],
expressed
as
triadimefon,
in
or
on
the
following
raw
agricultural
commodities:

§
180.410(
c)
raspberry
Tolerances
with
regional
registration
are
established
for
the
combined
residues
of
the
fungicide
1­(
4­
chlorophenoxy)­
3,3­
dimethyl­
1­(
1H­
1,2,4­
triazol­
1­
yl)­
2­
butanone
[
triadimefon]
and
$­(
4­
chlorophenoxy)­"­(
1,1­
dimethylethyl)­
1H­
1,2,4­
triazole­
1­
ethanol
[
triadimenol],
expressed
as
triadimefon,
in
or
on
the
following
raw
agricultural
commodities:

Tolerances
Established
Under
40
CFR
§
180.410(
a)

Sufficient
field
trial
data
reflecting
the
maximum
label
use
pattern
are
available
to
reassess
the
established
tolerances
for
the
following
RACs
as
defined:
apples,
grapes,
pears,
pineapples,
and
raspberries.
Likewise,
acceptable
feeding
studies
are
available
to
reassess
the
tolerances
for
the
following
livestock
commodities:
milk,
eggs,
and
the
fat,
meat
byproducts,
and
meat
of
cattle,
goats,
horses,
and
sheep.

The
established
tolerances
for
the
following
plant
commodities
should
be
revoked
because
the
registrant
is
not
supporting
use
of
triadimefon
on
these
commodities:
barley,
milled
fractions
(
except
flour);
cucurbits;
grass,
forage;
grass,
seed
screenings
(
including
hulls);
grass,
seed
straw
(
including
chaff);
nectarines;
sugar
beets;
sugar
beets,
tops;
wheat,
grain;
wheat,
green
forage;
wheat,
milled
fractions
(
except
flour);
and
wheat,
straw.
The
established
tolerances
for
residues
in
dry
apple
pomace,
wet
and
dry
grape
pomace,
and
raisin
waste
should
be
revoked
because
these
commodities
are
no
longer
considered
significant
livestock
feed
items.
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The
established
tolerances
for
RACs
listed
under
40
CFR
§
180.410(
a)
are
reassessed
at
the
same
levels
except
those
listed
for
apples,
pears,
and
pineapples;
reduced
tolerances
may
be
established
for
these
crops
to
reflect
reevaluation
of
field
trial
data.

Triadimefon
is
not
registered
for
use
as
a
direct
livestock
treatment.
The
nature
of
the
residue
in
livestock
is
adequately
defined
for
the
current
uses.
HED
concludes
that
the
supported
registered
uses
on
apples,
grapes,
pears,
pineapples,
and
raspberries
result
in
a
40
CFR
§
180.6(
a)(
3)
situation
for
ruminant
commodities;
i.
e.,
there
is
no
reasonable
expectation
of
finite
residues
in
livestock
commodities.
Therefore,
additional
data
on
the
transfer
of
residues
to
meat,
milk,
poultry,
and
eggs
are
not
required
and
all
tolerances
for
livestock
commodities
should
be
revoked.

The
available
apple
processing
data
indicate
that
triadimefon
residues
of
concern
concentrate
in
wet
pomace
(
1.6x)
but
do
not
concentrate
in
juice
(
reduction
factor
of
0.6x).
Based
on
the
HAFT
residues
for
apples
(<
0.09
ppm)
and
the
concentration
factor
for
wet
pomace,
expected
triadimefon
residues
of
concern
in
wet
pomace
are
0.14
ppm.
Because
the
expected
residues
are
less
than
the
reassessed
tolerance
for
apples
(
0.2
ppm),
no
tolerance
for
apple
wet
pomace
is
required.

Tolerances
To
Be
Proposed
Under
40
CFR
§
180.410(
a)

The
available
data
indicate
that
residues
of
triadimefon
concentrate
4x
in
raisins.
Based
on
HAFT
residues
for
grapes
(<
0.62
ppm)
and
the
concentration
factor
for
raisins,
expected
triadimefon
residues
of
concern
in
raisins
are
2.5
ppm,
which
is
significantly
greater
than
the
reassessed
tolerance
for
the
RAC
(
1.0
ppm).
Therefore,
a
tolerance
of
2.5
ppm
must
be
proposed
for
residues
in
raisins.

Tolerances
with
Regional
Registrations
Established
Under
40
CFR
§
180.410(
c)

A
tolerance
with
regional
registration
has
been
established
for
raspberries.
Sufficient
field
trial
data
are
available
to
assess
the
established
tolerance
with
regional
registration
for
raspberry
at
the
same
level
under
40
CFR
§
180.410(
c).

Table
10.
Tolerance
Reassessment
Summary
for
Triadimefon.

Commodity
Current
Tolerance
(
ppm)
Reassessed
Tolerance
(
ppm)
Comment
[
Correct
Commodity
Definition]

Tolerances
Established
Under
40
CFR
§
180.410(
a)

Apple
1.0
0.2
New
data
from
field
trails
show
lower
residues
are
expected.

Apple,
wet
pomace
and
Apple,
dry
pomace
4.0
Revoke
The
available
data
indicate
that
a
tolerance
for
wet
apple
pomace
is
not
required,
and
dry
apple
pomace
is
no
longer
considered
a
significant
livestock
feed
item.

Barley,
milled
fractions
(
except
flour)
4.0
Revoke
Currently,
Bayer
does
not
have
any
registered
uses
of
triadimefon
on
barley.
1
Beet,
sugar
0.5
Revoke
Currently,
Bayer
does
not
have
any
registered
uses
of
triadimefon
on
sugar
beets.
Triadimefon
Summary
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Chemistry
and
Residue
Data
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Table
10.
Tolerance
Reassessment
Summary
for
Triadimefon.

Commodity
Current
Tolerance
(
ppm)
Reassessed
Tolerance
(
ppm)
Comment
[
Correct
Commodity
Definition]

25
of
44
Beet,
sugar,
tops
3.0
Cattle,
fat
1.0
Revoke
40
CFR
§
180.6(
a)(
3)
Cattle,
meat
1.0
Revoke
Cattle,
meat
byproducts
1.0
Revoke
Chickpea,
seed
0.1
Revoke
Currently,
Bayer
does
not
have
any
registered
uses
of
triadimefon
on
chickpea
plants.

Cucurbits
0.3
Revoke
Bayer
does
not
intend
to
support
use
of
triadimefon
on
cucurbits.

Eggs
0.04
Revoke
Currently,
Bayer
does
not
have
any
registered
uses
of
triadimefon
on
any
poultry
feed
items.
40
CFR
§
180.6(
a)(
3)

Goat,
fat
1.0
Revoke
40
CFR
§
180.6(
a)(
3)
Goat,
meat
1.0
Revoke
Goat,
meat
byproducts
1.0
Revoke
Grape
1.0
1.0
No
change.

Grape,
wet
pomace
and
Grape,
dry
pomace
3.0
Revoke
No
longer
considered
significant
livestock
feed
items.
Grape,
raisin,
waste
7.0
Grass,
forage
0.2
Revoke
Currently,
Bayer
does
not
have
any
registered
uses
of
triadimefon
on
pasture
or
rangeland.
Grass,
seed
screenings
145.0
Grass,
straw,
grown
for
seed
105.0
Hog,
fat
0.04
Revoke
Currently,
Bayer
does
not
have
any
registered
uses
of
triadimefon
on
any
hog
feed
items.
40
CFR
§
180.6(
a)(
3)
Hog,
meat
0.04
Hog,
meat
byproducts
0.04
Horse,
fat
1.0
Revoke
40
CFR
§
180.6(
a)(
3)
Horse,
meat
1.0
Horse,
meat
byproducts
1.0
Milk
0.04
Revoke
40
CFR
§
180.6(
a)(
3)

Nectarine
4.0
Revoke
Currently,
Bayer
does
not
have
any
registered
uses
of
triadimefon
on
nectarine.

Pear
1.0
0.2
New
data
from
field
trails
show
lower
residues
are
expected.

Pineapple,
fresh
3.0
2.0
Reevaluation
of
data
from
field
trails
show
lower
residues
are
expected.
[
Pineapple]
Triadimefon
Summary
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
314742
Table
10.
Tolerance
Reassessment
Summary
for
Triadimefon.

Commodity
Current
Tolerance
(
ppm)
Reassessed
Tolerance
(
ppm)
Comment
[
Correct
Commodity
Definition]

26
of
44
Poultry,
fat
0.04
Revoke
Currently,
Bayer
does
not
have
any
registered
uses
of
triadimefon
on
any
poultry
feed
items.
40
CFR
§
180.6(
a)(
3)
Poultry,
meat
0.04
Poultry,
meat
byproducts
0.04
Sheep,
fat
1.0
Revoke
40
CFR
§
180.6(
a)(
3)
Sheep,
meat
1.0
Sheep,
meat
byproducts
1.0
Wheat,
forage
15.0
Revoke
Currently,
Bayer
does
not
have
any
registered
uses
of
triadimefon
on
wheat.
Wheat,
grain
1.0
Wheat,
milled
fractions
(
except
flour)
4.0
Wheat,
straw
5.0
Tolerances
To
Be
Proposed
Under
40
CFR
§
180.410(
a)

Grape,
raisin
None
established
2.5
Tolerances
Established
Under
40
CFR
§
180.410(
c)

Raspberry
2.0
2.0
No
change.

1.
Tolerances
for
barley
commodities
were
revoked
in
1997,
based
on
the
fact
that
use
on
barley
had
been
canceled
in
1993.
This
food
additive
tolerance
was
mistakenly
re­
instated
when
the
revocation
of
all
triadimefon
food
additive
tolerances
(
due
to
Delaney
clause
issues)
was
withdrawn
after
FQPA
was
enacted.

Codex
Harmonization
The
Codex
Alimentarius
Commission
(
Codex)
has
established
several
maximum
residue
limits
(
MRLs)
for
triadimefon
in/
on
various
raw
agricultural
commodities.
The
Codex
MRLs
are
expressed
in
terms
of
triadimefon
per
se.
Compatibility
cannot
be
achieved
with
the
Codex
MRLs
because
these
levels
are
expressed
in
terms
of
triadimefon
only;
the
U.
S.
tolerances
for
plant
commodities
are
expressed
in
terms
of
triadimefon
and
triadimenol.
Additionally,
all
U.
S.
livestock
tolerances
should
be
revoked.
A
numerical
comparison
of
the
Codex
MRLs
and
the
corresponding
reassessed
U.
S.
tolerances
is
presented
in
Table
11.

Table
11.
Codex
MRLs
for
Triadimefon
and
Applicable
U.
S.
Tolerances.

Codex
Reassessed
U.
S.
Tolerance
(
ppm)
Codex
Comments
Commodity
MRL1
(
mg/
kg)
Step
Barley
0.5
CXL
None3
Barley
straw
and
fodder,
Dry
2
CXL
None
Chick­
pea
(
dry)
0.05
(*)
CXL
Revoke
Triadimefon
Summary
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
314742
Table
11.
Codex
MRLs
for
Triadimefon
and
Applicable
U.
S.
Tolerances.

Codex
Reassessed
U.
S.
Tolerance
(
ppm)
Codex
Comments
Commodity
MRL1
(
mg/
kg)
Step
27
of
44
Coffee
beans
0.05
(*)
CXL
None
Currants,
Black,
Red,
White
0.2
CXL
None
Eggs
0.05
(*)
CXL
Revoke
Fodder
beet
0.05
(*)
CXL
None
Fodder
beet
leaves
or
tops
0.05
(*)
CXL
None
Fruiting
vegetables,
Cucurbits
0.1
CXL
Revoke
Grapes
0.5
CXL
1.0
Hops,
Dry
10
CXL
None
Mango
0.05
(*)
CXL
None
Meat
(
from
mammals
other
than
marine
mammals)
0.05
(*)
CXL
Revoke
Milks
0.05
(*)
CXL
Revoke
Oat
straw
and
fodder,
Dry
2
CXL
None
Oats
0.1
CXL
None
Onion,
Welsh
0.05
(*)
CXL
None
Peas
(
pods
and
succulent=
immature
seeds)
0.05
(*)
CXL
None
Peppers,
Sweet
0.1
CXL
None
Pineapple
22
CXL
2.0
Pome
fruits
0.5
CXL
None
Poultry
meat
0.05
(*)
CXL
Revoke
Raspberries,
Red,
Black
1
CXL
2.0
Rye
0.1
CXL
None
Rye
straw
and
fodder,
Dry
2
CXL
None
Spring
onion
0.05
(*)
CXL
None
Strawberry
0.1
CXL
None
Sugar
beet
0.1
(*)
CXL
Revoke
Sugar
beet
leaves
or
tops
2
CXL
Revoke
Triadimefon
Summary
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
314742
Table
11.
Codex
MRLs
for
Triadimefon
and
Applicable
U.
S.
Tolerances.

Codex
Reassessed
U.
S.
Tolerance
(
ppm)
Codex
Comments
Commodity
MRL1
(
mg/
kg)
Step
28
of
44
Tomato
0.2
CXL
None
Wheat
0.1
CXL
Revoke
Wheat
straw
and
fodder,
Dry
2
CXL
Revoke
1.
Asterisk
designates
MRL
set
at
the
limit
of
quantitation.
2.
Resulting
from
postharvest
application.
3.
The
basic
producer
does
not
have
registered
uses
of
triadimefon
on
this
commodity.

Bibliography
Agency
Memoranda
Citations
DP
Barcode:
D174365
Subject:
ID­
HI­
920003.
Triadimefon:
24
(
c)
on
pineapple
processed
commodities
in
the
State
of
Hawaii.
CBTS
#
9336
From:
J.
Morales
To:
C.
Giles­
Parker
and
Toxicology
Branch
Dated:
3/
9/
92
MRID:
None
DP
Barcode:
D177806
Subject:
Triadimefon.
Case
#
2700.
Waiver
and
Extension
Requests:
Storage
Stability
Data
and
Processing
Study.
CBRS
#
9851.
From:
L.
Cheng
To:
M.
Wilhite
Dated:
6/
9/
92
MRID:
None
DP
Barcode:
D179962
Subject:
FIFRA
6(
a)(
2)
Data
and
Reregistration
of
Triadimefon
(
Bayleton).
Processing
Studies
for
Apples
and
Grapes.
CBRS
No.
10114
From:
S.
Funk
To:
M.
Wilhite
Dated:
7/
24/
92
MRID:
42346601
and
42346701
DP
Barcode:
D175489
Subject:
PP#
2F2688/
FAP#
2H5636.
Triadimefon
(
Bayleton
®
50%
WP
Fungicide;
EPA
Reg.
No.
3125­
320)
in
or
on
Pineapple
Bran
as
a
Feed
Additive
(
Guideline
#
171­
4(
l)).
Evaluation
of
Analytical
Method
and
Residue
Data.
CBRS
#
9547.
From:
F.
Toghrol
To:
C.
Giles­
Parker/
J.
Stone
Dated:
9/
18/
92
MRID:
42013201
Triadimefon
Summary
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
314742
29
of
44
DP
Barcode:
D174151
Subject:
Triadimefon.
List
B
Reregistration
Case
No.
2700/
Chemical
ID
No.
109901.
Raw
data
to
upgrade
metabolism
studies
reviewed
in
Phase
4.
Phase
5
Review
of
subject
studies.
CBRS
No.
9422.
From:
C.
Swartz
To:
B.
Sidwell
Dated:
9/
23/
92
MRIDs:
42123400­
42123404
DP
Barcodes:
D179335,
D181031,
and
D181032
Subject:
Triadimefon.
Reregistration
Case
No.
2700.
Guideline
171­
4(
k)
Magnitude
of
the
residue
studies
for
apples,
pears,
cucumbers,
summer
squash,
cantaloupes,
grapes,
and
pineapples.
From:
S.
Knizner
To:
M.
Wilhite/
B.
Sidwell
Dated:
12/
10/
92
MRIDs:
41809401
and
42342303­
42342308
DP
Barcodes:
D168542
and
D178884
Subject:
Triadimefon
(
109901):
Storage
Stability
Data,
PAM
Multiresidue
Methods,
Product
Chemistry
Data.
CBRS
Nos.
8566
and
9929.
From:
S.
Hummel
To:
M.
Wilhite/
B.
Sidwell
Dated:
12/
22/
92
MRIDs:
41976601,
41976602,
and
42307801­
42307803
DP
Barcode:
D183726
Subject:
PP#
3E4164
Triadimefon
(
Bayleton
®
50%
Wettable
Powder
(
EPA
Reg.
No.
3125­
320)
and
Bayleton
®
50%
Wettable
Powder
Fungicide
in
water
soluble
pouches
(
EPA
Reg.
No.
3125­
340))
in
or
on
the
Pome
Fruit
Crop
Group.
CBTS
No.
10762
From:
D.
Davis
To:
H.
Jamerson
Dated:
2/
12/
93
MRID:
None
DP
Barcode:
D180656
Subject:
PP3E2938.
Triadimefon
on
coffee.
Amendment
of
5/
28/
92.
CB
No.
10239.
From:
R.
Cook
To:
C.
Giles­
Parker
Dated:
7/
6/
93
MRIDs:
42332701
DP
Barcode:
D194719
Subject:
Triadimefon.
List
B
Reregistration
Case
No.
2700/
Chemical
ID
No.
109901.
Submission
of
Raw
Data
to
Upgrade
Cucumber
and
Tomato
Metabolism
Studies.
CBRS
No.
12515
From:
C.
Swartz
To:
B.
Sidwell
Dated:
10/
20/
93
MRIDs:
42798900
and
42798901
DP
Barcode:
D194786
Subject:
Triadimefon.
Poultry
Metabolism
Study.
Reregistration
Case
No.
2700.
Chemical
No.
109901.
CBRS
#
12530.
From:
Steven
A.
Knizner
To:
M.
Wilhite
Triadimefon
Summary
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
314742
30
of
44
Dated:
11/
2/
93
MRID:
42864901
DP
Barcode:
D194819
Subject:
Triadimefon.
Ruminant
Metabolism
Study.
Reregistration
Case
No.
2700.
Chemical
No.
109901.
CBRS
#
12514.
From:
Steven
A.
Knizner
To:
M.
Wilhite
Dated:
11/
2/
93
MRID:
42856801
DP
Barcode:
D186937
Subject:
Triadimefon.
Confined
Rotational
Crop
Study.
Reregistration
Case
No.
2700.
Chemical
No.
109901.
CBRS
#
11212.
From:
Steven
A.
Knizner
To:
M.
Wilhite
Dated:
11/
3/
93
MRID:
42613301
DP
Barcode:
D194676
Subject:
Triadimefon.
Wheat
Metabolism
Study.
Reregistration
Case
No.
2700.
Chemical
No.
109901.
CBRS
#
12527.
From:
Steven
A.
Knizner
To:
M.
Wilhite
Dated:
11/
3/
93
MRID:
42853401
DP
Barcode:
D194783
Subject:
Triadimefon.
Storage
Stability
Study.
Reregistration
Case
No.
2700.
Chemical
No.
109901.
CBRS
#
12528.
From:
Steven
A.
Knizner
To:
M.
Wilhite
Dated:
11/
7/
93
MRID:
42857401
DP
Barcode:
None
Subject:
Triadimefon.
Issues
to
be
Presented
at
the
12/
1/
93
Meeting
of
the
HED
Metabolism
Committee.
Reregistration
Case
No.
2700.
Chemical
No.
109901.
From:
Steven
A.
Knizner
To:
HED
Metabolism
Committee
Dated:
11/
29/
93
MRIDs:
None
DP
Barcode:
None
Subject:
Triadimefon.
Addendum
to
Wheat,
Ruminant,
and
Poultry
Metabolism
Studies
and
Confined
Rotational
Crop
Study.
Reregistration
Case
No.
2700.
Chemical
No.
109901.
From:
Steven
A.
Knizner
To:
M.
Wilhite
Dated:
12/
9/
93
MRIDs:
42853401,
42856801,
42864901,
and
42613301
DP
Barcode:
None
Subject:
Triadimefon.
Outcome
of
the
12/
1/
93
Meeting
of
the
HED
Metabolism
Committee.
Reregistration
Case
No.
2700.
Chemical
No.
109901.
From:
Steven
A.
Knizner
To:
Files
and
HED
Metabolism
Committee
Triadimefon
Summary
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
314742
31
of
44
Dated:
1/
3/
94
MRIDs:
None
DP
Barcode:
D208890
Subject:
Triadimefon.
Data
Submitted
to
Upgrade
Ruminant
and
Poultry
Metabolism
Studies
and
Analysis
of
Tissues
from
Metabolism
Study
with
Analytical
Enforcement
Method.
Reregistration
Case
No.
2700.
Chemical
No.
109901.
CBRS
#
14659
From:
Steven
A.
Knizner
To:
M.
Wilhite
Dated:
12/
16/
94
MRIDs:
43418301,
43418302,
and
43418303
DP
Barcodes:
D209623
and
D209629
Subject:
ID
#
s
003125­
00320
Bayleton
50%
WP
Fungicide
&
#
003125­
00340
Bayleton
50%
WP
Fungicide:
Triadimefon
in/
on
Pineapple;
Amendment
dated
November
14,
1994
From:
Amended
Registration
Team
To:
C.
Giles­
Parker/
J.
Stone
Dated:
2/
21/
95
MRID:
None
DP
Barcode:
D210160
Subject:
Triadimefon.
Meat,
Milk,
Eggs
Storage
Stability
Study.
Reregistration
Case
No.
2700.
Chemical
No.
109901.
CBRS
#
14826
From:
S.
Knizner
To:
M.
Wilhite
Dated:
2/
23/
95
MRID:
43462401
DP
Barcode:
D205423
Subject:
Triadimefon.
Grape
Processing
Study.
Reregistration
Case
No.
2700.
Chemical
No.
109901.
CBRS
#
14186
From:
S.
Knizner
To:
R.
Kendall
Dated:
2/
23/
95
MRID:
43284401
DP
Barcode:
D215215
Subject:
Triadimefon
on
Apples
and
Grapes.
Application
of
DES
Proviso
to
Existing
Feed
Additive
Tolerances.
CBTS
#
15526
From:
G.
Herndon
To:
E.
Haeberer
Dated:
5/
24/
95
MRID:
None
DP
Barcode:
None
Subject:
PP#
3E4164.
Triadimefon
in
or
on
the
Pome
Fruit
Crop
Group.
Addendum
to
2/
12/
93
Memorandum.
From:
D.
Davis
To:
H.
Jamerson,
J.
Stone,
and
R.
Kendall
Dated:
9/
13/
95
MRID:
None
DP
Barcode:
D220220
Subject:
Triadimefon
­
Evaluation
of
the
Need
for
the
Existing
Food
Additive
Tolerance
on
Wheat
Milled
Fractions
(
Except
Flour).
CBTS
#
16337.
From:
G.
Kramer
Triadimefon
Summary
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
314742
32
of
44
To:
N.
Nazmi
Dated:
10/
25/
95
MRID:
None
DP
Barcode:
D225223
Subject:
Triadimefon
­
Response
to
Comments
by
Bayer
on
the
Proposed
Revocation
of
the
Existing
Food
Additive
tolerance
on
Wheat
Milled
Fractions
(
Except
Flour).
From:
G.
Kramer
To:
N.
Nazmi
Dated:
4/
25/
96
MRID:
None
DP
Barcode:
D223368
Subject:
Triadimefon.
PP#
2E4044.
IR­
4
Petition
for
Tolerance
In/
On
Artichoke,
globe.
From:
S.
Knizner
To:
H.
Jamerson
Dated:
9/
3/
96
MRID:
43897501
DP
Barcode:
D229635
Subject:
ID#
96MN0004
Section
Crisis
18
Exemption
for
Use
of
Triadimefon
on
Chili
peppers
in
the
State
of
New
Mexico.
From:
S.
Knizner,
C.
Lewis,
W.
Dykstra,
and
D.
Davis
To:
D.
Deegan
Dated:
9/
17/
96
MRID:
None
DP
Barcodes:
D234272
and
D235085
Subject:
ID#
97MI0006
&
97CA0032.
Section
18
Exemptions
for
Use
of
Triadimefon
on
Asparagus
in
Michigan
and
Artichokes
in
California.
From:
S.
Knizner,
S.
Williams­
Foy,
W.
Dykstra,
C.
Lewis,
and
M.
Nelson
To:
O.
Odiott
and
D.
Deegan/
M.
Johnson
Dated:
7/
30/
97
MRID:
None
DP
Barcode:
D238236
Subject:
ID#
97MI0006
&
97CA0032.
Section
18
Exemptions
for
Use
of
Triadimefon
on
Asparagus
in
Michigan
and
Artichokes
in
California.
From:
R.
Loranger
To:
O.
Odiott
and
D.
Deegan/
M.
Johnson
Dated:
8/
14/
97
MRID:
None
DP
Barcodes:
D220498
and
D238509
Subject:
PP#
3E4164.
Triadimefon
on
Pome
Fruits.
Residue
Chemistry
Disciplinary
Review
of
the
IR­
4
Amendments
dated
10/
6/
95
and
3/
12/
97:
Revised
Sections
B
and
F.
From:
M.
Nelson
To:
H.
Jamerson
Dated:
3/
6/
98
MRID:
None
Triadimefon
Summary
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
314742
33
of
44
DP
Barcode:
D238130
Subject:
PP#
2E4044.
Triadimefon
on
Artichokes.
Residue
Chemistry
Disciplinary
Review
of
the
IR­
4
Amendment
dated
6/
7/
96.
Revised
Sections
B
and
F.
From:
M.
Nelson
To:
H.
Jamerson
Dated:
3/
6/
98
MRID:
None
DP
Barcode:
None
Subject:
Triadimefon.
Outcome
of
the
12/
1/
93
Meeting
of
the
HED
Metabolism
Committee.
From:
S.
Knizner
To:
Files
and
HED
Metabolism
Committee.
Dated:
1/
3/
94
MRID:
None
DP
Barcodes:
D222403,
D227497,
and
D227543
Subject:
Independent
Laboratory
Validation,
Radiovalidation
Data,
and
Storage
Stability
Data
From:
J.
Punzi
To:
B.
Chambliss
Dated:
7/
13/
00
MRIDs:
43870101,
44038901,
44041001,
and
44041002
DP
Barcode:
D321636
Subject:
Triadimefon.
Registrants
Response
to
Residue
Chemistry
Data
Requirements.
Magnitude
of
Triadimefon
Residues
of
Concern
in
Apple
Processed
Commodities.
From:
S.
Ary
To:
R.
Griffin
and
J.
Pates
Dated:
8/
31/
2005
MRID:
43948601
Master
Record
Identification
Numbers
41809401
Williams,
B.
(
1991)
Triadimefon:
Magnitude
of
the
Residue
Crop
Field
Trials:
Lab
Project
Number:
38613­
1:
BL19GR01:
100122.
Unpublished
study
prepared
by
Analytical
Bio­
Chemistry
Laboratories
Inc.
323
p.

41976601
Ver
Hey,
M.
(
1991)
Bayleton,
KWG
1323
and
KWG
1342:
Multiresidue
Method
Testing:
Lab
Project
Number:
MOBAY/
1093:
BL161601.
Unpublished
study
prepared
by
Colorado
Analytical
Research
&
Dev.,
Corp.
380
p.

41976602
Williams,
B.;
Conrath,
B.
(
1991)
Triadimefon/
Triadimenol
Freezer
Storage
Stability
Study
in
Wheat
Gain,
Grapes,
and
Tomatoes:
Amended
Report:
Lab
Project
Number:
36987­
1:
BL142301:
100105.
Unpublished
study
prepared
by
Analytical
Bio­
Chemistry
Laboratories.
417
p.

42013201
Pither,
K.
(
1991)
Triadimefon
(
500DF):
Magnitude
of
the
Residue
on
Pineapple
Processed
Products:
Lab
Project
Number:
BL19PN02B:
101325.
Unpublished
study
prepared
by
ABC
Labs,
Inc.
and
Maui
Pineapple
Company,
Ltd.
324
p.

42123401
Krolski,
M.
(
1991)
Addendum
I:
Raw
Data
on
the
Fate
of
?
carbon
14|
Triadimefon
on
Tomatoes
and
Cucumbers:
Lab
Project
Number:
68593
­
1.
Unpublished
study
prepared
by
Stoner
Labs,
Inc.
20
p.

42123402
Minor,
R.
(
1991)
Addendum
I:
Raw
Data
for
the
Metabolism
of
Triadim
efon
in
Apples:
Lab
Project
Number:
53621­
1.
Unpublished
study
prepared
by
Mobay
Corp.
19
p.

42123403
Duah,
F.
(
1991)
Addendum
I:
Raw
Data
on
The
Metabolism
of
Bayleton
on
Grapes:
Lab
Project
Number:
88790­
1.
Unpublished
study
pre­
pared
by
Mobay
Corp.
27
p.
Triadimefon
Summary
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
314742
34
of
44
42123404
Chopade,
H.
(
1991)
Addendum
I:
Raw
Data
for
the
Metabolism
of
Triadimefon
in
Male
and
Female
Pigs:
Lab
Project
Number:
66509­
1.
51
p.

42332701
Chickering,
C.;
Williams,
B.
(
1992)
Triadimefon:
Magnitude
of
the
Residue
on
Coffee
Beans:
Lab
Project
Number:
39264­
1:
BL19CF01.
Unpublished
study
prepared
by
ABC
Laboratories,
Inc.
and
Mobay
Corp.
186
p.

42342303
Burger,
R.
(
1992)
Triadimefon
(
50DF)­­
Magnitude
of
the
Residue
on
Apples:
Lab
Project
Number:
BL
19AP01:
39590:
102625.
Unpublished
study
prepared
by
Miles,
Inc.
and
ABC
Laboratories.
386
p.

42342304
Burger,
R.
(
1992)
Triadimefon
(
50DF)­­
Magnitude
of
the
Residue
on
Cantaloupe:
Lab
Project
Number:
BL
19CP01:
39585:
102628.
Unpublished
study
prepared
by
Miles,
Inc.
and
ABC
Laboratories.
319
p.

42342305
Burger,
R.
(
1992)
Triadimefon
(
50DF)­­
Magnitude
of
the
Residue
on
Cucumber:
Lab
Project
Number:
BL
19CU01:
39586:
102630.
Unpublished
study
prepared
by
Miles,
Inc.
and
ABC
Laboratories.
409
p.

42342306
Burger,
R.
(
1992)
Triadimefon
(
50DF)­­
Magnitude
of
the
Residue
on
Pears:
Lab
Project
Number:
BL
19PR01:
39592:
102626.
Unpublished
study
prepared
by
Miles,
Inc.
and
ABC
Laboratories.
303
p.

42342307
Burger,
R.
(
1992)
Triadimefon
(
50DF)­­
Magnitude
of
the
Residue
on
Pineapple:
Lab
Project
Number:
BL
19PN02:
39256:
102649.
Unpublished
study
prepared
by
Miles,
Inc.,
ABC
Laboratories,
and
Dole
Packaged
Foods
Co.
416
p.

42342308
Burger,
R.
(
1992)
Triadimefon
(
50DF)­­
Magnitude
of
the
Residue
on
Summer
Squash:
Lab
Project
Number:
BL
19SQ01:
39589:
102629.
Unpublished
study
prepared
by
Miles,
Inc.
and
ABC
Laboratories.
420
p.

42346601
Burger,
R.
(
1992)
Triadimefon
(
50DF)­
Magnitude
of
the
Residue
on
Processed
Apple
Commodities:
Lab
Project
Number:
BL­
19AP02:
39591:
102636.
Unpublished
study
prepared
by
Miles
Inc.
and
ABC
Laboratories.
233
p.

42346701
Burger,
R.
(
1992)
Triadimefon
(
50DF)­
Magnitude
of
the
Residue
on
Processed
Grape
Commodities:
Lab
Project
Number:
BL19GR02:
39587:
RP
5522.
Unpublished
study
prepared
by
Miles
Inc.,
ABC
Laboratories,
Inc.
and
The
National
Food
Laboratory
Inc.
277p.

42613301
Mattern,
G.
C.,
Parker,
G.
D.,
and
Wendt,
S.
N.
(
1992)
Confined
Accumulation
of
[
phenyl­
UL­
14C]
Triadimefon
Residues
in
Rotational
Crops.
Laboratory
Study
Nos.:
Miles,
Inc.:
BL051601;
Plant
Sciences,
Inc.:
91.027;
PTRL
West,
Inc.:
P309W;
Miles
Report
No.
103806.
Unpublished
study
conducted
by
Plant
Sciences,
Inc.,
Watsonville,
CA
and
PTRL
West,
Inc.,
Richmond,
CA,
and
sponsored
by
Miles,
Inc.,
Kansas
City,
MO.
152
p.

42798901
Krolski,
M.
(
1993)
Fate
of
Bayleton­(
carbon
14)
as
a
25
Percent
Wettable
Powder
on
Tomatoes
and
Cucumbers.
Mass
Spectral
Data
on
(
carbon
14)
Triadimefon
Residues.

42853401
Chopade,
H.
(
1993)
Metabolism
of
(
Phenyl­
UL­(
carbon
14))
Triadimefon
in
Wheat:
Lab
Project
Number:
BL041601:
105162.
Unpublished
study
prepared
by
Miles
Inc.,
Agricultural
Div.
141
p.

42856801
Hall,
L.;
Hartz,
A.
(
1993)
The
Metabolism
of
(
carbon
14)
Triadimefon
in
the
Lactating
Goat:
Lab
Project
Number:
BL041001:
105161.
Unpublished
study
prepared
by
Miles
Inc.
160
p.

42857401
Williams,
B.
and
Chickering,
C.
(
1993)
Triadimefon
and
Metabolites­
Freezer
Storage
Stability
Study
in
Raw
Agricultural
Commodities
and
Processed
Products
Agricultural
Commodities
and
Processed
Products:
Lab
Project
Number:
396832:
BL131601:
102641­
1.
Unpublished
study
prepared
by
ABC
Labs,
Inc.
150
p.

42864901
Duah,
F.;
Smasal,
T.
(
1993)
Metabolism
of
Triadimefon
in
Laying
Hens:
Lab
Project
Number:
BL040501:
105183.
Unpublished
study
prepared
by
Miles
Inc.
129
p.
Triadimefon
Summary
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
314742
35
of
44
43284401
Burger,
R.
(
1994)
Triadimefon
(
50DF):
Magnitude
of
the
Residue
in
Processed
Grape
Commodities:
Lab
Project
Number:
105043:
BL19GR03:
40712.
Unpublished
study
prepared
by
Miles
Inc.
in
cooperation
with
ABC
Laboratories,
Inc.
and
The
National
Food
Laboratory,
Inc.
648
p.

43418301
Hall,
L.;
Hartz,
A.
(
1994)
The
Metabolism
of
(
carbon
14)
Triadimefon
in
the
Lactating
Goat:
Addendum
1:
Additional
Data
as
Requested
by
the
EPA:
Lab
Project
Number:
BL041001:
105161­
1.
Unpublished
study
prepared
by
Miles,
Inc.
12
p.

43418302
Duah,
F.;
Myers,
T.
(
1994)
Metabolism
of
Triadimefon
in
Laying
Hens:
Addendum
1:
Additional
Data
as
Requested
by
EPA:
Lab
Project
Number:
BL040501:
105183­
1.
Unpublished
study
prepared
by
Miles,
Inc.
17
p.

43418303
Duah,
F.;
Myers,
T.;
Freeseman,
P.
(
1994)
Extraction
Efficiency
of
the
Analytical
Method
for
Triadimefon
Residues
in
Meat,
Milk,
and
Eggs:
Lab
Project
Numbers:
BL200201:
106449.
Unpublished
study
prepared
by
Miles,
Inc.
44
p.

43462401
Duah,
F.
(
1994)
Storage
Stability
of
Triadimefon
Residues
in
Animal
Tissues,
Milk,
and
Eggs:
Lab
Project
Number:
BL130201:
106638.
Unpublished
study
prepared
by
Miles
Inc.
37
p.

43870101
Bajzik,
M.
(
1995)
Independent
Laboratory
Validation
of
the
Analytical
Residue
Method
for
Triadimefon
and
Metabolites
in
Plant
Matrices
(
Report
No.
106549):
Lab
Project
Number:
A012.014:
BL111601:
107141.
Unpublished
study
prepared
by
Huntingdon
Analytical
Services.
121
p.

43897501
Thompson,
D.
(
1996)
Triadimefon­­
in/
on
Artichokes:
(
Additional
Magnitude
of
the
Residue
Trials):
Lab
Project
Number:
3530:
3530.
AA­
CAR02:
3530.
AA­
CA03.
Unpublished
study
prepared
by
IR­
4
Western
Region
Residue
Lab.
335
p.

44029301
Grace,
T.
(
1996)
BAYLETON
50WP
­
Magnitude
of
the
Residue
in
Wheat
Processed
Products:
Lab
Project
Number:
BL19WH02:
107130:
PR95322.
Unpublished
study
prepared
by
Bayer
Corp.;
Texas
A&
M
University;
and
Maxim
Technologies,
Inc.
2508
p.

44038901
Lenz,
C.
(
1996)
Triadimefon
and
Metabolites­
Freezer
Storage
Stability
Study
in
Raw
Agricultural
Commodities
and
Processed
Commodities:
Addendum
2:
Lab
Project
Number:
BL131601:
102641­
2:
39683.
Unpublished
study
prepared
by
ABC
Laboratories,
Inc.
586
p.

44041001
Chopade,
H.
(
1996)
Metabolism
of
(
Phenyl­
UL­(
carbon
14))
Triadimefon
in
Wheat:
Addendum
1­­
Storage
Stability
of
(
carbon14)
KWG
1732
in
Wheat
Grain:
Lab
Project
Number:
BL221601:
105162­
1.
Unpublished
study
prepared
by
Bayer
Corp.
30
p.

44041002
Chopade,
H.
(
1996)
Extraction
Efficiency
of
the
Analytical
Residue
Method
for
the
Determination
of
Triadimefon
and
Metabolite
Residues
in
Plant
Matrices:
Determination
of
Aged
(
carbon
14)
Triadimefon
Residues
in
Wheat
Grain:
Lab
Project
Number:
BL221601:
107343.
Unpublished
study
prepared
by
Bayer
Corp.
35
p.

92188025
Chopade,
H.
(
1990)
Mobay
Corporation
Phase
3
Summary
of
MRID
00025540.
The
Metabolism
of
BAYLETON
in
Apples:
Project
Report
No.
53621.
Prepared
by
MOBAY
CORPORATION.
14
p.

92188026
Mango,
R.;
Puhl,
R.;
Thornton,
J.
(
1990)
Mobay
Corporation
Phase
3
Reformat
of
MRID
00025540.
The
Metabolism
of
BAYLETON
in
Apples:
Project
No.
53621.
Prepared
by
MOBAY
CORPORATION.
26
p.

92188027
Chopade,
H.
(
1990)
Mobay
Corporation
Phase
3
Summary
of
MRID
00031440
and
Related
MRIDs
00031441.
Fate
of
BAYLETON­
Carbon­
14
as
a
25%
Wettable
Powder
on
Tomatoes
and
Cucumbers:
Project
Report
Nos.
68593
and
68594.
Prepared
by
MOBAY
CORPORATION.
13
p.

92188028
Nye,
D.
(
1990)
Mobay
Corporation
Phase
3
Reformat
of
MRID
00031440.
Fate
of
BAYLETON­
Carbon­
14
as
a
25
Percent
Wettable
Powder
on
Tomatoes
and
Cucumbers:
Project
Report
68593.
Prepared
by
STONER
LABORATORIES,
INC.
33
p.
Triadimefon
Summary
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
314742
36
of
44
92188029
Puhl,
R.
(
1990)
Mobay
Corporation
Phase
3
Reformat
of
MRID
00031441.
Further
Identification
of
Polar
Activity
from
BAYLETON
Cucumber
and
Tomato
Metabolism
Samples:
Project
Report
No.
68594.
Prepared
by
MOBAY
CORPORATION.
10
p.

92188030
Chopade,
H.
(
1990)
Mobay
Corporation
Phase
3
Summary
of
MRID
00098115.
Metabolism
of
BAYLETON
in
Wheat:
Project
Report
No.
80293.
Prepared
by
MOBAY
CORPORATION.
14
p.

92188031
Morgan,
J.;
Lenz,
M.
(
1990)
Mobay
Corporation
Phase
3
Reformat
of
MRID
00098115.
Metabolism
of
BAYLETON
in
Wheat:
Project
Report
No.
80293.
Prepared
by
MOBAY
CORPORATION.
29
p.

92188032
Chopade,
H.
(
1990)
Mobay
Corporation
Phase
3
Summary
of
MRID
00150893.
Metabolism
of
BAYLETON
on
Grapes:
Project
Report
No.
88790.
Prepared
by
MOBAY
CORPORATION.
12
p.

92188033
Fredrickson,
R.
(
1990)
Mobay
Corporation
Phase
3
Reformat
of
MRID
00150893.
Metabolism
of
BAYLETON
on
Grapes:
Project
Report
No.
88790.
Prepared
by
MOBAY
CORPORATION.
21
p.

92188034
Chopade,
H.
(
1990)
Mobay
Corporation
Phase
3
Summary
of
MRID
00025543.
Metabolism
of
BAYLETON
in
the
Cow:
Project
Report
No.
66202.
Prepared
by
MOBAY
CORPORATION.
11
p.

92188035
Fredrickson,
D.
(
1990)
Mobay
Corporation
Phase
3
Reformat
of
MRID
00025543.
Metabolism
of
BAYLETON
in
the
Cow:
Project
Report
No.
66202.
Prepared
by
MOBAY
CORPORATION.
19
p.

92188036
Premkumar,
N.
(
1990)
Mobay
Corporation
Phase
3
Summary
of
MRID
00033058.
Metabolism
of
BAYLETON
in
Male
and
Female
Pigs:
Project
No.
66509.
Prepared
by
MOBAY
CORPORATION.
16
p.

92188037
Pither,
K.
(
1990)
Mobay
Corporation
Phase
3
Reformat
of
MRID
00033058.
Metabolism
of
BAYLETON
in
Male
and
Female
Pigs:
Project
Report
No.
66509.
Prepared
by
MOBAY
CORPORATION.
25
p.

92188038
Mathew,
A.
(
1990)
Mobay
Corporation
Phase
3
Summary
of
MRID
00033070.
The
Fate
of
BAYLETON­
Carbon­
14
in
Poultry:
Project
Report
No.
67482.
Prepared
by
MOBAY
CORPORATION.
16
p.

92188039
Nye,
D.
(
1990)
Mobay
Corporation
Phase
3
Reformat
of
MRID
00033070.
The
Fate
of
BAYLETONCarbon
14
in
Poultry:
Project
Report
No.
67482.
Prepared
by
STONER
LABORATORIES,
INC.
67
p.

92188040
Obrist,
J.;
Nichols,
S.;
Leimkuehler,
W.
(
1990)
Mobay
Corporation
Phase
3
Reformat
of
MRID
00025546.
An
Interference
Study
for
the
BAYLETON
and
KWG
0519
Residue
Method
for
Crops:
Project
Report
No.
68006.
Prepared
by
MOBAY
CORPORATION.
208
p.

92188041
Leimkuehler,
W.
(
1990)
Mobay
Corporation
Phase
3
Reformat
of
MRID
00125782.
An
Interference
Study
for
BAYLETON
Residue
Method
for
Crops
­
Resolution
of
Interference
for
KWG
1342
and
KWG
1323:
Project
Report
No.
80567.
Prepared
by
MOBAY
CORPORATION.
225
p.

92188042
Chopade,
H.
(
1990)
Mobay
Corporation
Phase
3
Summary
of
MRID
00149163
and
Related
MRIDs
00025546,
00125782.
Residue
Analysis
Procedure
for
BAYLETON
and
Metabolites
in
Plants:
Project
Report
Nos.
80488,
68006
and
80567.
Prepared
by
MOBAY
CORPORATION.
16
p.

92188043
Obrist,
J.;
Leimkuehler,
W.
(
1990)
Mobay
Corporation
Phase
3
Reformat
of
MRID
00149163.
Residue
Analysis
Procedure
for
BAYLETON
and
Metabolites
in
Barley
and
Wheat:
Project
Report
No.
80488.
Prepared
by
MOBAY
CORPORATION.
28
p.

92188044
Minor,
R.
(
1990)
Mobay
Corporation
Phase
3
Summary
of
MRID
00090019
and
Related
MRIDs
00090020,
00063837,
00072538,
00149342,
00063835.
Analytical
Methods
for
BAYLETON
in
Various
Animal
Tissues:
Project
Report
Nos.
69531,
80265,
68705,
68798,
69028
and
68887.
Prepared
by
ANALYTICAL
DEVELOPMENT
CORP.
21
p.

92188045
Kruplak,
J.
(
1990)
Mobay
Corporation
Phase
3
Reformat
of
MRID
00090019.
BAYLETON
Total
Triadimefon
Summary
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
314742
37
of
44
Residue
Method
Verification
(
Bovine):
Project
Report
No.
69531.
Prepared
by
ANALYTICAL
DEVELOPMENT
CORP.
158
p.

92188046
Obrist,
J.
Nichols,
S.
(
1990)
Mobay
Corporation
Phase
3
Reformat
of
MRID
00063835.
An
Interference
Study
for
the
BAYLETON
and
KWG
0519
Residue
Method
for
Bovine
Tissues
and
Milk:
Project
report
No.
68887.
Prepared
by
MOBAY
CORPORATION.
67
p.

92188047
Kruplak,
J.
Weissenburger,
B.
Bache,
.
(
1990)
Mobay
Corporation
Phase
3
Reformat
of
MRID
00063837.
Determination
of
BAYLETON
and
KWG
0519
in
Cattle
Tissues:
Project
Report
No.
68705.
Prepared
by
ANALYTICAL
DEVELOPMENT
CORP.
31
p.

92188048
Kruplak,
J.
Bache,
B.
Breault,
G.
(
1990)
Mobay
Corporation
Phase
3
Reformat
of
MRID
00072538.
Residue
Analysis
Procedure
for
the
Determination
of
BAYLETON
and
KWG
0519
in
Bovine
Milk:
Project
Report
No.
68798.
Prepared
by
ANALYTICAL
DEVELOPMENT
CORP.
19
p.

92188051
Premkumar,
N.
(
1990)
Mobay
Corporation
Phase
3
Summary
of
MRID
00025541
and
Related
MRIDs
00098117,
41027902.
Storage
Stability
of
BAYLETON,
BAYTAN,
KWG
1323
and
KWG
1342
in
Apple
Peel,
Potatoes,
Grapes
and
Wheat
Green
Forage;
and
Storage
Stability
of
KWG
1323
and
KWG
1342
in
Wheat
Grain:
Project
Report
Nos.
54192,
80338
and
98432.
Prepared
by
MOBAY
CORPORATION.
11
p.

92188052
Thornton,
J.
(
1990)
Mobay
Corporation
Phase
3
Reformat
of
MRID
00025541.
The
Stability
of
BAYLETON
and
KWG
0519
Residues
in
Apple
Peel
During
Frozen
Storage:
Project
Report
No.
54192.
Prepared
by
MOBAY
CORPORATION.
8
p.

92188053
Fredrickson,
D.
(
1990)
Mobay
Corporation
Phase
3
Reformat
of
MRID
00098117.
The
Stability
of
BAYLETON
and
BAYTAN
Residues
in
Wheat
Forage
During
Storage:
Project
Report
No.
80338.
Prepared
by
MOBAY
CORPORATION.
7
p.

92188054
Bornatsch,
W.
(
1990)
Mobay
Corporation
Phase
3
Summary
of
MRID
00090021.
Effect
of
Feeding
BAYLETON
and
the
Metabolite
KWG
0519
(
BAYTAN)
to
Dairy
Cattle
­­
Total
Residue:
Project
Report
No.
69930.
Prepared
by
MOBAY
CORPORATION.
9
p.

92188055
Kruplak,
J.
(
1990)
Mobay
Corporation
Phase
3
Reformat
of
MRID
00090021.
Effect
of
Feeding
BAYLETON
and
the
Metabolite
KWG
0519
(
BAYTAN)
to
Dairy
Cattle
­­
Total
Residues:
Project
Report
No.
69930.
Prepared
by
ANALYTICAL
DEVELOPMENT
CORP.
247
p.

92188056
Mathew,
A.
(
1990)
Mobay
Corporation
Phase
3
Summary
of
MRID
00090022.
Effect
of
Feeding
BAYLETON
and
the
Metabolite
KWG
0519
(
BAYTAN)
to
Poultry
­
Total
Residue:
Project
No.
80281.
Prepared
by
MOBAY
CORPORATION.
12
p.

92188057
Kruplak,
J.;
and
Weissenburger,
B.
(
1990)
Mobay
Corporation
Phase
3
Reformat
of
MRID
00090022.
Effect
of
Feeding
BAYLETON
and
the
Metabolite
KWG
0519
(
BAYTAN)
to
Poultry
­
Total
Residues:
Project
Report
No.
80281.
Prepared
by
ANALYTICAL
DEVELOPMENT
CORP.
174
p.

92188059
Leslie,
W.
(
1990)
Mobay
Corporation
Phase
3
Summary
of
MRID
00098114
and
Related
MRIDs
00149329.
Triadimefon
(
BAYLETON
50WP
Formulation)
­
Magnitude
of
the
Residues
on
Barley:
Objective
No.
(
3015)
Project
Report
Nos
80492,
80493,
80541,
80543,
80554,
80555,
80556,
80559,
80561,
82820,
82826
and
82827;
Mobay
Report
100112­
1.
Prepared
by
MOBAY
CORPORATION.
12
p.

92188060
Leslie,
W.
(
1990)
Mobay
Corporation
Phase
3
Summary
of
MRID
00067381
and
Related
MRIDs
00109463.
Triadimefon
(
BAYLETON
25WP
Formulation)
­
Magnitude
of
the
Residues
on
Chick
Peas:
Project
Report
Nos.
68905,
68906,
68907,
68908,
68909,
80723,
80930
and
80931;
Mobay
Report
No.
100117­
1.
Prepared
by
MOBAY
CORPORATION.
13
p.

92188061
Biehn,
W.
(
1990)
Mobay
Corporation
Phase
3
Summary
of
MRID
00143953
and
Related
MRIDs
00153279.
Triadimefon:
Magnitude
of
the
Residue
on
Raspberries:
IR­
4
No.
2552.
Prepared
by
ICI
Americas
Inc.
Triadimefon
Summary
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
314742
38
of
44
20
p.

92188062
Leslie,
W.
(
1990)
Mobay
Corporation
Phase
3
Summary
of
MRID
00072532
and
Related
MRIDs
00149342.
Triadimefon
(
BAYLETON
50WP
Formulation)
­
Magnitude
of
the
Residues
on
Seed
Grass:
Project
Report
Nos.
80670,
80673,
80674,
80675
and
80676;
Mobay
Report
No.
100114­
1.
Prepared
by
MOBAY
CORPORATION.
12
p.

92188064
Leslie,
W.
(
1990)
Mobay
Corporation
Phase
3
Summary
of
MRID
00098114
and
Related
MRIDs
00149329,
00061736.
Magnitude
of
the
Residues
on
Wheat:
Objective
No.
(
3012):
Report
Nos.
80494,
80495,
80530,
80542,
80545,
80546,
80547,
80550,
80551,
80552,
80553,
82821,
82874,
84208,
82822
and
82824;
Mobay
Report
No.
100111­
1.
Prepared
by
MOBAY
CORPORATION.
14
p.

92188074
Leslie,
W.
(
1990)
Mobay
Corporation
Phase
3
Reformat
of
MRID
00098114
and
Related
MRIDs
00149329,
00061736.
Triadimefon
(
BAYLETON
50WP
Formulation)
­
Magnitude
of
the
Residues
on
Wheat:
(
Report
Nos.
80494,
80495,
80530,
80542,
80545,
80546,
80547,
80550,
80551,
80552,
80553,
82821,
82874,
84208,
82822,
82824);
Mobay
Report
No.
100111.
Prepared
by
MOBAY
CORPORATION.
219
p.

92188075
Leslie,
W.
(
1990)
Mobay
Corporation
Phase
3
Reformat
of
MRID
00072532
and
Related
MRIDs
00149342.
Triadimefon
(
BAYLETON
50WP
Formulation)
­
Magnitude
of
the
Residues
on
Seed
Grass:
Project
Report
Nos.
(
80670,
80673,
80674,
80675,
80676,
82848,
82854,
82855,
82856,
82857,
82858);
Mobay
Report
100114.
Prepared
by
MOBAY
CORPORATION.
121
p.

92188076
Leslie,
W.
(
1990)
Mobay
Corporation
Phase
3
Reformat
of
MRID
00098114
and
Related
MRIDs
00149329.
Magnitude
of
the
Residues
on
Barley:
Project
Nos.
(
80492,
80493,
80541,
80543,
80551,
80554,
80555,
80558,
80559,
80560,
80561,
82826,
84207);
Mobay
Report
No.
100112.
Prepared
by
MOBAY
CORPORATION.
182
p.

92188063
Leslie,
W.
(
1990)
Mobay
Corporation
Phase
3
Summary
of
MRID
00128337.
Triadimefon
(
BAYLETON
50WP
Formulation)
Magnitude
of
the
Residues
on
Sugar
Beets:
Project
Report
Nos.
81198,
81199,
82800,
82801,
82802,
82803,
82804,
82805,
82806,
82807,
82808,
82809,
82811,
82814,
82815,
82816,
82817
and
82818;
Mobay
Report
100115­
1.
Prepared
by
MOBAY
CORPORATION.
17
p.

92188065
Leslie,
W.
(
1990)
Mobay
Corporation
Phase
3
Summary
of
MRID
00128337.
Triadimefon
(
BAYLETON
50WP
Formulation)
­
Magnitude
of
the
Residue
in
Unprocessed
Sugar
Beets
and
Sugar
Beet
Processed
Products:
Project
Report
Nos.
84211,
84212
and
82811;
Mobay
Report
No.
100116­
1.
Prepared
by
MOBAY
CORPORATION.
12
p.

92188069
Leslie,
W.
(
1990)
Mobay
Corporation
Phase
3
Reformat
of
MRID
00128337.
Triadimefon
(
BAYLETON
50WP
Formulation)
­
Magnitude
of
the
residues
in
Unprocessed
Sugar
Beets
and
Sugar
Beet
processed
Products:
Project
Nos.
(
82811,
84211,
84212);
Mobay
Report
No.
100116.
Prepared
by
MOBAY
CORPORATION.
56
p.

92188073
Leslie,
W.
(
1990)
Mobay
Corporation
Phase
3
Reformat
of
MRID
00128337.
Triadimefon
(
BAYLETON
50WP)
­
Magnitude
of
the
Residues
on
Sugar
Beets:
(
Project
Nos.
81198,
81199,
82205,
82206,
82207,
82800,
82801,
82802,
82812,
82813,
82814,
82815,
82816,
82817,
82818);
Mobay
Report
No.
10115.
Prepared
by
MOBAY
CORPORATION.
204
p.
Triadimefon
Summary
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
314742
39
of
44
Appendix
1.
Food/
Food
Use
Patterns
for
Triadimefon.

This
document
was
originally
prepared
by
the
Biological
and
Economic
Analysis
Division
(
BEAD).
Current
as
of:
5/
9/
2005.

SITE
NAME
LIMITATIONS
Application
Timing
(
for
any
Reg.#
at
any
rate)

Application
Type
(
for
any
Reg.#
at
any
rate).
Max.
Single
Appl.
Form
Code(
s)
Max.
Seasonal
Max.
#

Apps/
M
R
I
R
E
I
PHI/
PGI/
PSI
Use
Limitations
(
May
not
Triadimefon
Summary
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
314742
40
of
44
Application
Equipment
(
for
any
Reg.#
at
any
rate).
Rate
to
a
Single
Site
Rate
cc
&
yr
apply
to
all
Reg.
#
s)

APPLE
12
months
rotational/
plant
back
crop
restriction.

45
day(
s)
preharvest
interval.

Do
not
apply
directly
to
water,
or
to
areas
where
surface
water
is
present
or
to
intertidal
areas
below
the
mean
high
water
mark.

Do
not
apply
through
any
type
of
irrigation
system.

Do
not
apply
when
drift
is
likely
to
occur.

Do
not
contaminate
water
by
cleaning
of
equipment
or
disposal
of
equipment
wash
waters.

Do
not
contaminate
water,
food,
or
feed
by
storage
or
disposal.

Do
not
graze
livestock
in
treated
orchards.

Do
not
use
clippings
for
animal
feed.

Do
not
use
on
crops
grown
for
food
or
forage.

Groundwater
restriction.

__
months
rotational/
plant
back
crop
restriction.

Delayed
dormant
through
petal
fall
High
volume
spray
(
dilute)
/
Low
volume
spray
(
concentrate).

Aircraft
/
High
volume
ground
sprayer
/
Low
volume
ground
sprayer.
0.25
lb
A
WP
0.75
lb/
cc
NS
NS
7
12
h
Delayed
dormant
High
volume
spray
(
dilute)
/
Low
volume
spray
(
concentrate).

Aircraft
/
High
volume
ground
sprayer
/
Low
volume
ground
sprayer.
0.25
lb
A
WP
0.75
lb/
cc
NS
NS
AN
12
h
Foliar
High
volume
spray
(
dilute)
/
Low
volume
spray
(
concentrate).

Aircraft
/
High
volume
ground
sprayer
/
Low
volume
ground
sprayer.
0.25
lb
A
WP
0.75
lb/
cc
NS
NS
AN
12
h
When
needed
High
volume
spray
(
dilute).

High
volume
ground
sprayer.
0.2469
lb
A
WP
9.26E­
0
3
lb/
cc
3/
cc
NS
7
NS
GRAPES
12
months
rotational/
plant
back
crop
restriction.

14
day(
s)
preharvest
interval.

Do
not
apply
directly
to
water,
or
to
areas
where
surface
water
is
present
or
to
intertidal
areas
below
the
mean
high
water
mark.

Do
not
apply
through
any
type
of
irrigation
system.
Triadimefon
Summary
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
314742
41
of
44
Do
not
apply
when
drift
is
likely
to
occur.

Do
not
contaminate
water
by
cleaning
of
equipment
or
disposal
of
equipment
wash
waters.

Do
not
contaminate
water,
food,
or
feed
by
storage
or
disposal.

Do
not
use
clippings
for
animal
feed.

Do
not
use
on
crops
grown
for
food
or
forage.

Groundwater
restriction.

__
months
rotational/
plant
back
crop
restriction.

Bloom
Low
volume
spray
(
concentrate).

Aircraft
/
Low
volume
ground
sprayer.
0.1875
lb
A
WP
0.5625
lb/
cc
NS
NS
14
12
h
Delayed
dormant
through
petal
fall
Low
volume
spray
(
concentrate).

Aircraft.
0.125
lb
A
WP
0.5625
lb/
cc
NS
NS
7
12
h
Foliar
Low
volume
spray
(
concentrate)
/
Spray.

Aircraft
/
Ground
/
Low
volume
ground
sprayer.
0.1875
lb
A
FlC,
WP
0.5625
lb/
cc
NS
NS
14
12
h
Posttransplant
Low
volume
spray
(
concentrate).

Low
volume
ground
sprayer.
0.125
lb
A
WP
0.5625
lb/
cc
NS
NS
7
12
h
Prebloom
through
petal
fall
High
volume
spray
(
dilute)
/
Low
volume
spray
(
concentrate).

Aircraft
/
High
volume
ground
sprayer
/
Low
volume
ground
sprayer.
0.1875
lb
A
WP
0.5625
lb/
cc
3/
cc
NS
14
12
h
Prebloom
Low
volume
spray
(
concentrate).

Aircraft
/
Low
volume
ground
sprayer.
0.1875
lb
A
WP
0.5625
lb/
cc
NS
NS
14
12
h
When
needed
High
volume
spray
(
dilute).

High
volume
ground
sprayer.
0.1874
lb
A
WP
0.01405
lb/
cc
3/
cc
NS
7
NS
PEAR
12
months
rotational/
plant
back
crop
restriction.

45
day(
s)
preharvest
interval.

Do
not
apply
directly
to
water,
or
to
areas
where
surface
water
is
present
or
to
intertidal
areas
below
the
mean
high
water
mark.
Triadimefon
Summary
Analytical
Chemistry
and
Residue
Data
DP
Barcode:
314742
42
of
44
Do
not
apply
through
any
type
of
irrigation
system.

Do
not
apply
when
drift
is
likely
to
occur.

Do
not
contaminate
water
by
cleaning
of
equipment
or
disposal
of
equipment
wash
waters.

Do
not
contaminate
water,
food,
or
feed
by
storage
or
disposal.

Do
not
graze
livestock
in
treated
orchards.

Do
not
use
clippings
for
animal
feed.

Do
not
use
on
crops
grown
for
food
or
forage.

Groundwater
restriction.

__
months
rotational/
plant
back
crop
restriction.

Delayed
dormant
through
petal
fall
High
volume
spray
(
dilute)
/
Low
volume
spray
(
concentrate).

Aircraft
/
High
volume
ground
sprayer
/
Low
volume
ground
sprayer.
0.25
lb
A
WP
0.75
lb/
cc
3/
cc
NS
7
12
h
Delayed
dormant
High
volume
spray
(
dilute)
/
Low
volume
spray
(
concentrate).

Aircraft
/
High
volume
ground
sprayer
/
Low
volume
ground
sprayer.
0.25
lb
A
WP
0.75
lb/
cc
NS
NS
AN
12
h
Foliar
High
volume
spray
(
dilute)
/
Low
volume
spray
(
concentrate).

Aircraft
/
High
volume
ground
sprayer
/
Low
volume
ground
sprayer.
0.25
lb
A
WP
0.75
lb/
cc
NS
NS
AN
12
h
When
needed
High
volume
spray
(
dilute).

High
volume
ground
sprayer.
0.003086
lb/
5
gal
WP
9.26E­
0
3
lb/
cc
3/
cc
NS
7
NS
PINEAPPLE
12
months
rotational/
plant
back
crop
restriction.

Do
not
apply
directly
to
water,
or
to
areas
where
surface
water
is
present
or
to
intertidal
areas
below
the
mean
high
water
mark.

Do
not
apply
through
any
type
of
irrigation
system.

Do
not
apply
when
drift
is
likely
to
occur.

Do
not
contaminate
water
by
cleaning
of
equipment
or
disposal
of
equipment
wash
waters.

Do
not
contaminate
water,
food,
or
feed
by
storage
or
disposal.

Do
not
feed
waste
from
treated
pineapples
to
dairy
or
meat
animals.

Do
not
use
forage
or
fodder
for
animal
feed.

Do
not
use
on
crops
grown
for
food
or
forage.

Groundwater
restriction.

Geographic
allowable:
HI
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44
Postharvest
Dip
treatment
/
Seed
treatment
/
Spray.

Dip
tank
/
Sprayer.
0.28125
lb/
100
gal
DF,
WP
NS
NS
NS
NS
12
h
Seed
piece
Dip
treatment.

Dip
tank.
0.28125
lb/
100
gal
DF,
WP
NS
NS
NS
NS
12
h
When
needed
Directed
spray.

Hand
held
sprayer.
0.28125
lb
A
WP
NS
1/
cc
NS
NS
12
h
RASPBERRY
(
BLACK,
RED)
1
day(
s)
preharvest
interval.

12
months
rotational/
plant
back
crop
restriction.

Do
not
apply
directly
to
water,
or
to
areas
where
surface
water
is
present
or
to
intertidal
areas
below
the
mean
high
water
mark.

Do
not
apply
through
any
type
of
irrigation
system.

Do
not
apply
when
drift
is
likely
to
occur.

Do
not
contaminate
water
by
cleaning
of
equipment
or
disposal
of
equipment
wash
waters.

Do
not
contaminate
water,
food,
or
feed
by
storage
or
disposal.

Do
not
use
clippings
for
animal
feed.

Groundwater
restriction.

__
months
rotational/
plant
back
crop
restriction.

Geographic
allowable:
CA
Foliar
Low
volume
spray
(
concentrate).

Low
volume
ground
sprayer.
0.125
lb
A
WP
NS
NS
7/
1
yr
28
12
h
PRODUCT
NUMBERS
CONTAINED
IN
THIS
REPORT
000264­
00737,
000264­
00757,
000432­
01293,
000432­
01294,
HI03000400,
HI92000300
HOMEOWNER
PRODUCTS
CONTAINED
IN
THIS
REPORT
000432­
01293
HEADER
ABBREVIATIONS
Site
Name
­
The
site
name
refers
to
the
entity
(
crop,
building,
surface
or
article)
where
a
pesticide
is
applied
and/
or
which
is
being
protected.

Limitations
­
Precautionary
statements
related
to
the
use
of
the
product(
s).

Application
Timing
­
The
timing
of
pesticide
application
and
is
the
primary
application
sort
(
not
aggregated).

Application
Type
­
The
type
of
pesticide
application
(
aggregated).

Application
Equipment
­
The
equipment
used
to
apply
pesticide
(
aggregated).
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Max.
Single
Appl.
Rate
to
a
Single
Site
­
Maximum
Dose
for
a
single
application
to
a
single
site.
System
calculated.

Form
­
The
physical
form
of
the
end
use
product
found
in
the
container.

Max
Seasonal
Rate
­
The
maximum
amount
of
pesticide
that
can
be
applied
to
a
site
in
one
growing
season
(/
cc)
and
during
the
span
of
one
year
(/
yr).

Max.
#
Apps/
cc
&
yr
­
Maximum
Number
of
Applications
per
crop
cycle
and
per
year.

M
R
I
­
Minimum
Retreatment
Interval
(
days)
(
at
any
rate).
The
minimum
interval
between
pesticide
application
(
days).

R
E
I
­
ReEntry
Interval
­
The
minimum
amount
of
time
that
must
elapse
before
workers
can
reenter
a
treated
area.

PHI/
PGI/
PSI
Use
Limitations
(
May
not
apply
to
all
Reg.#
s)
­
Preharvest/
Pregrazing/
Preslaughter
Interval
use
limitations
pertinent
to
the
application.

Current
As
Of:
­
The
label
data
for
the
listed
products
in
this
report
is
current
as
of
this
date.

ABBREVIATIONS
AN
­
As
needed
NA
­
Not
Applicable
NS
­
Not
Specified
(
on
label)

(
L)
­
The
dosage
information
provided
is
from
the
label
in
terms
of
product
(
e.
g.,
ounces,
gallons,
or
pounds
of
the
product)
because
there
was
insufficient
information
(
e.
g.,
missing
density,
area,
or
active
ingredient
percentages)
to
provide
converted
dosage
information.
This
report
provides
active
ingredient
percentage
in
the
product
for
the
reported
chemical
for
all
unconverted
label
dosage
information
if
this
information
is
available.
This
active
ingredient
percentage
information
is
displayed
next
to
the
form
code
abbreviations
(
e.
g.,
80%
WP).

UC
­
Unconverted
due
to
lack
of
data
(
on
label).

APPLICATION
RATE
W
:
PPM
calculated
by
weight
V
:
PPM
calculated
by
volume
U
:
Unknown
whether
PPM
is
given
by
weight
or
by
volume
~
:
The
dosage
information
includes
a
contribution
from
one
or
more
(
TQ,
CL,
BR,
I)
active
ingredients.

cwt
:
Hundred
Weight
nnE­
xx
:
nn
times
(
10
power
­
xx),
for
instance,
"
1.234E­
04"
is
equivalent
to
".
0001234"

FORMULATION
CODES
DF
:
Water
Dispersible
Granules
(
dry
Flowable)

FlC
:
Flowable
Concentrate
WP
:
Wettable
Powder
