Page
1
of
39
UNITED
STATES
ENVIRONMENTAL
PROTECTION
AGENCY
WASHINGTON,
D.
C.
20460
OFFICE
OF
PREVENTION,
PESTICIDES,
AND
TOXIC
SUBSTANCES
MEMORANDUM
Date:
November
23,
2005
Subject:
Triadimefon.
Acute
and
Chronic
Dietary
Exposure
Assessments
for
the
Reregistration
Eligibility
Decision
(
RED)
Document.

DP
Barcode:
D314778
PC
Code:
109901
40
CFR
§
:
180.410
Chemical
Class:
Triazole
From:
Samuel
Ary,
Chemist
Reregistration
Branch
II
Health
Effects
Division
(
7509C)

Through:
Thurston
Morton,
Chemist
David
Soderberg,
Chemist
Dietary
Exposure
Science
Advisory
Council
(
DESAC)
Health
Effects
Division
(
7509C)

Alan
Nielsen,
Branch
Senior
Scientist
Reregistration
Branch
II
Health
Effects
Division
(
7509C)

To:
Richard
Griffin,
Risk
Assessor
Reregistration
Branch
II
Health
Effects
Division
(
7509C)

John
Pates,
Chemical
Review
Manager
Reregistration
Branch
I
Special
Review
and
Reregistration
Division
(
7508C)
Triadimefon
Dietary
Exposure
Assessment
­
RED
DP
Barcode:
314778
Page
2
of
39
Executive
Summary
Acute
and
chronic
dietary
(
food
and
water)
exposure
assessments
were
conducted
using
the
Dietary
Exposure
Evaluation
Model
software
with
the
Food
Commodity
Intake
Database
(
DEEM­
FCID
 
,
Version
2.03),
which
uses
food
consumption
data
from
the
USDA's
Continuing
Surveys
of
Food
Intakes
by
Individuals
(
CSFII)
from
1994­
1996
and
1998.
The
acute
and
chronic
dietary
risk
assessments
were
conducted
for
all
supported
triadimefon
food
uses
and
were
performed
to
support
the
reregistration
eligibility
decision
document.

Triadimefon,
1­(
4­
chlorophenoxy)­
3,3­
dimethyl­
1­(
1H­
1,2,4­
triazol­
1­
yl)­
2­
butanone
is
a
systemic
fungicide
used
to
control
rust
and
mildew
on
apples,
grapes,
pears,
pineapples,
and
raspberries.
Triadimefon
end­
use
products
are
marketed
in
the
United
States
under
the
trade
name
Bayleton
®
and
Summit.
The
reregistration
of
triadimefon
is
being
supported
by
Bayer
CropScience,
the
basic
producer.

Acute
Dietary
Exposure
Results
and
Characterization
of
Input
Data
A
highly
refined
probabilistic
(
Monte­
Carlo)
acute
dietary
exposure
assessment
was
conducted
to
estimate
the
dietary
risks
associated
with
the
reregistration
of
triadimefon.
The
acute
dietary
exposure
assessment
incorporated
percent
crop
treated
(%
CT)
estimates
provided
by
the
Biological
Economic
Analysis
Division
(
BEAD)
and
DEEM
7.81
default
processing
factors
along
with
the
available
data
from
the
processing
studies.
The
anticipated
residue
(
AR)
estimates
are
based
on
USDA
PDP
monitoring
data
(
PDP
data)
and
field
trial
data.
The
assessment
also
included
the
30
year
annual
peak
surface
water
distribution
of
concentrations
that
was
generated
using
the
maximum
allowable
number
of
applications
per
year.
Acute
dietary
risk
estimates
are
provided
for
the
general
U.
S.
population
and
various
population
subgroups,
with
the
major
emphasis
placed
on
the
exposure
estimates
for
infants
and
children.
This
assessment
concludes
that
for
all
supported
commodities,
the
acute
dietary
risk
estimates
exceed
HED's
level
of
concern
(
greater
than
100%
of
the
aPAD)
at
the
99.9th
exposure
percentile
for
the
U.
S.
population
(
840%
of
the
aPAD)
and
all
population
subgroups,
with
the
highest
exposed
population
subgroup
being
all
infants
less
than
one
year
old
at
2400%
of
the
aPAD.

The
acute
dietary
risk
estimates
for
food
alone
(
no
water)
exceed
HED's
level
of
concern
at
the
99.9th
exposure
percentile
for
children
1­
2
years
old
at
240%
of
the
aPAD,
children
3­
5
years
old
at
170%.
The
acute
dietary
risk
estimate
does
not
exceed
HED's
level
of
concern
for
the
U.
S.
population
at
72%
of
the
aPAD.

It
is
also
noted
that
the
acute
dietary
risk
estimates
for
either
surface
water
concentrations
(
no
food),
26
applications
or
3
applications,
exceed
HED's
level
of
concern
at
the
99.9th
exposure
percentile
for
the
U.
S.
population
and
all
population
subgroups.

For
comparison,
the
estimated
surface
water
distribution
of
concentrations
using
a
typical
number
of
3
applications
per
year
was
incorporated
into
the
acute
dietary
exposure
assessment.
For
all
supported
commodities,
the
acute
dietary
risk
estimates
exceed
HED's
level
of
concern
at
the
99.9th
exposure
percentile
for
the
U.
S.
population
(
230%
of
the
aPAD)
and
all
population
subgroups,
with
the
highest
exposed
population
subgroup
being
all
infants
less
than
one
year
old
at
710%
of
the
aPAD.
Triadimefon
Dietary
Exposure
Assessment
­
RED
DP
Barcode:
314778
Page
3
of
39
The
significant
acute
risk
contributors
have
been
identified
as
water
(
direct
and
indirect,
all
sources),
grape
juice,
pineapple
juice,
raisins,
and
fresh
grapes.
The
estimated
drinking
water
concentrations
used
in
this
assessment
are
calculated
using
26
applications
per
year
to
turf,
which
is
the
maximum
number
of
applications
allowed
in
a
single
year.
This
may
be
overly
conservative
because
Bayer
has
indicated
the
typical
application
rate
to
be
3
applications
per
year.

PDP
data
are
available
for
grapes
and
pineapples,
however,
because
the
monitoring
data
did
not
analyze
for
all
triadimefon
metabolites
of
concern,
the
ratio
of
total
toxic
residues
(
TTR)
to
triadimefon
from
available
metabolism
studies
were
used
to
estimate
the
total
residues
of
concern.
This
presented
a
factor
of
70.7x,
which
would
produce
AR
estimates
that
are
overly
conservative.
Therefore,
grape
and
pineapple
field
trial
data
were
incorporated
into
the
assessment.
Field
trial
data
and
%
CT
usage
data
were
available
for
pineapple,
however,
a
high
number
of
detectable
residues,
the
high
usage
estimate
of
100%
CT,
and
high
consumption
resulted
in
pineapple
being
a
major
acute
food
risk
contributor.
Field
trial
data
and
%
CT
usage
data
were
available
for
grapes,
however,
a
high
number
of
detectable
residues
and
high
consumption
resulted
in
grapes
being
a
major
acute
food
risk
contributor.
The
AR
estimates
are
considered
moderately
refined,
although
they
are
considered
highly
conservative
based
on
the
nature
of
the
residue
data
source
since
field
trial
studies
use
maximum
application
rates
and
minimum
pre­
harvest
intervals.
These
estimates
may
be
further
refined
in
the
future
with
additional
monitoring
data
that
samples
for
all
residues
of
concern;
however,
no
additional
data
are
available
at
this
time
to
further
refine
the
dietary
risk
estimates
to
triadimefon.

Chronic
Dietary
Exposure
Results
and
Characterization
of
Input
Data
A
highly
refined
chronic
dietary
exposure
assessment
was
conducted
to
estimate
the
dietary
risks
associated
with
the
reregistration
of
triadimefon.
The
chronic
dietary
exposure
assessment
incorporated
%
CT
estimates
provided
by
BEAD
and
DEEM
7.81
default
processing
factors
along
with
the
available
data
from
the
processing
studies.
The
AR
estimates
are
based
on
PDP
data
and
field
trial
data.
The
assessment
also
included
the
1
in
10
year
annual
mean
surface
water
concentration
that
was
generated
using
the
maximum
allowable
number
of
applications
per
year.
Chronic
dietary
risk
estimates
are
provided
for
the
general
U.
S.
population
and
various
population
subgroups,
with
the
major
emphasis
placed
on
the
exposure
estimates
for
infants
and
children.
This
assessment
concludes
that
for
all
supported
commodities,
the
chronic
dietary
risk
estimates
exceed
HED's
level
of
concern
(
greater
than
100%
of
the
cPAD)
for
all
infants
less
than
one
year
old
at
300%
of
the
cPAD,
children
1­
2
years
old
at
140%
of
the
cPAD,
and
children
3­
5
years
old
at
130%
of
the
cPAD.
The
chronic
dietary
risk
estimate
does
not
exceed
HED's
level
of
concern
(
less
than
100%
of
the
cPAD)
for
the
U.
S.
population
at
91%
of
the
cPAD.

The
chronic
dietary
risk
estimates
for
food
alone
(
no
water)
do
not
exceed
HED's
level
of
concern
for
the
U.
S.
population
(
less
than
1%
of
the
cPad)
and
all
population
subgroups,
with
the
highest
exposed
population
subgroup
being
children
1­
2
years
old
at
2%
of
the
cPAD.

The
chronic
dietary
risk
estimates
for
the
surface
water
concentration
(
no
food)
that
was
generated
using
26
applications
exceed
HED's
level
of
concern
for
all
infants
less
than
one
year
old
at
300%
of
the
cPad,
children
1­
2
years
old
at
140%
of
the
cPad,
and
children
3­
5
years
old
at
130%
of
the
cPad.
The
chronic
dietary
risk
estimate
does
not
exceed
HED's
level
of
concern
for
the
U.
S.
population
at
91%
of
the
cPAD.
Triadimefon
Dietary
Exposure
Assessment
­
RED
DP
Barcode:
314778
Page
4
of
39
For
comparison,
the
estimated
surface
water
concentration
using
a
typical
number
of
3
applications
per
year
was
incorporated
into
the
chronic
dietary
exposure
assessment.
For
all
supported
commodities,
the
chronic
dietary
risk
estimates
do
not
exceed
HED's
level
of
concern
for
the
U.
S.
population
(
16%
of
the
cPad)
and
all
population
subgroups,
with
the
highest
exposed
population
subgroup
being
all
infants
less
than
one
year
old
at
52%
of
the
cPad.

The
significant
chronic
risk
contributors
have
been
identified
as
water
(
direct
and
indirect,
all
sources).
The
estimated
drinking
water
concentration
used
in
this
assessment
was
calculated
using
26
applications
per
year
to
turf,
which
is
the
maximum
number
of
applications
allowed
in
a
single
year.
This
may
be
overly
conservative
because
Bayer
has
indicated
the
typical
application
rate
to
turf
to
be
3
applications
per
year.

Aggregate
Exposure
to
Triadimefon
and
Triadimenol
At
this
time
the
Agency
has
decided
not
to
aggregate
the
exposures
resulting
from
the
independent
use
of
triadimefon
and
triadimenol
(
metabolite
of
triadimefon).
This
decision
not
to
aggregate
was
based
on
the
risks
associated
with
the
use
of
triadimefon,
as
the
risk
from
triadimefon
already
exceed
the
Agency's
level
of
concern
by
itself.
Furthermore,
the
Agency
feels
that
aggregating
the
metabolite
triadimenol
exposures
from
use
of
triadimefon
with
the
exposures
resulting
from
the
use
of
triadimenol
would
not
allow
for
the
proper
evaluation
of
the
use
of
triadimenol
active
ingredient
products.
Should
refinements
be
possible
in
the
future,
it
may
be
possible
and
appropriate
to
aggregate
multiple
routes
and
sources
of
exposures
for
these
chemicals.

I.
Introduction
Dietary
risk
assessment
incorporates
both
exposure
and
toxicity
of
a
given
pesticide.
For
acute
and
chronic
assessments,
the
risk
is
expressed
as
a
percentage
of
a
maximum
acceptable
dose
(
i.
e.,
the
dose
which
the
Health
Effects
Division
has
concluded
will
result
in
no
unreasonable
adverse
health
effects).
This
dose
is
referred
to
as
the
population
adjusted
dose
(
PAD).
The
PAD
is
equivalent
to
the
Reference
Dose
(
RfD)
divided
by
the
special
FQPA
Safety
Factor.

For
acute
and
non­
cancer
chronic
exposures,
HED
is
concerned
when
estimated
dietary
risk
exceeds
100%
of
the
PAD.
References
which
discuss
the
acute
and
chronic
dietary
risk
assessments
in
more
detail
are
available
on
the
EPA
pesticides
web
site:
"
Available
Information
on
Assessing
Exposure
from
Pesticides,
A
User's
Guide,"
6/
21/
2000,
web
link:
http://
www.
epa.
gov/
fedrgstr/
EPA­
PEST/
2000/
July/
Day­
12/
6061.
pdf;
or
see
SOP
99.6
(
8/
20/
1999).

II.
Residue
Information
The
qualitative
nature
of
triadimefon
residues
in
plants
is
understood
based
on
the
adequate
metabolism
studies
conducted
with
grapes,
cucumbers,
tomatoes,
and
wheat.
The
Health
Effects
Division
(
HED)
Metabolism
Assessment
Review
Committee
(
MARC)
examined
the
results
of
these
studies
and
determined
that
the
residues
of
concern
in
plants
are
triadimefon,
triadimenol,
KWG
1323,
KWG
1342,
and,
in
cereal
grains,
triadimefon,
triadimenol,
KWG
1323,
KWG
1342,
and
KWG
1732
(
S.
Knizner,
HED
MARC
memorandum,
1/
3/
1994).
HED
has
revisited
the
Triadimefon
Dietary
Exposure
Assessment
­
RED
DP
Barcode:
314778
Page
5
of
39
MARC
decision
by
examining
all
the
available
metabolism
and
field
trial
data
and
determined
that
the
triadimefon
residues
of
concern
in/
on
apples,
grapes,
pears,
pineapples,
and
raspberries
for
tolerance
expression
are
triadimefon
and
triadimenol
and
for
risk
assessment
are
triadimefon,
triadimenol,
KWG
1323,
and
KWG
1342.

HED
determined
that
only
triadimefon
and
triadimenol
in
drinking
water
should
be
considered
in
the
dietary
risk
assessment
for
reasons
indicated
in
the
Drinking
Water
Data
Section
below.
Triadimefon
is
not
registered
for
use
as
a
direct
livestock
treatment.
HED
concluded
that
the
supported
uses
on
apples,
grapes,
pears,
pineapples,
and
raspberries
results
in
a
40
CFR
§
180.6(
a)(
3)
situation
for
livestock
commodities;
i.
e.,
there
is
no
reasonable
expectation
of
finite
residues
in
livestock
commodities.
Therefore,
tolerances
for
livestock
commodities
are
not
required
at
the
present
time
(
S.
Ary,
D314742,
11/
23/
2005).
Table
1
is
a
summary
of
the
HED
decisions
concerning
the
residues
of
concern
in
plants,
livestock,
and
drinking
water.

Table
1.
Summary
of
Metabolites
and
Degradates
to
be
Included
in
the
Risk
Assessment
and
Tolerance
Expression
for
Triadimefon.

Matrix
Residues
Included
in
Risk
Assessment
Residues
Included
in
Tolerance
Expression
Plants
Primary
crop
­
apple,
grape,
pear,
pineapple,
and
raspberry
triadimefon,
triadimenol,
KWG
1323,
and
KWG
1342
triadimefon
and
triadimenol
Rotational
crop
NA
=
not
applicable
NA
Livestock
Ruminant
NA
NA
Poultry
NA
NA
Drinking
water
triadimefon
and
triadimenol
NA
A
summary
of
the
triadimefon
tolerance
reassessment
and
recommended
modifications
in
commodity
definitions
is
presented
in
Table
2
(
S.
Ary,
D314742,
11/
23/
2005).

Table
2.
Tolerance
Reassessment
Summary
for
Triadimefon.

Commodity
Current
Tolerance
(
ppm)
Reassessed
Tolerance
(
ppm)
Comment
[
Correct
Commodity
Definition]

Tolerances
Established
Under
40
CFR
§
180.410(
a)

Apple
1.0
0.2
New
data
from
field
trails
show
lower
residues
are
expected.

Grape
1.0
1.0
No
change.

Pear
1.0
0.2
New
data
from
field
trails
show
lower
residues
are
expected.

Pineapple,
fresh
3.0
2.0
Reevaluation
of
data
from
field
trails
show
lower
residues
are
expected.
[
Pineapple]

Tolerances
To
Be
Proposed
Under
40
CFR
§
180.410(
a)

Grape,
raisin
None
established
2.5
Triadimefon
Dietary
Exposure
Assessment
­
RED
DP
Barcode:
314778
Table
2.
Tolerance
Reassessment
Summary
for
Triadimefon.

Commodity
Current
Tolerance
(
ppm)
Reassessed
Tolerance
(
ppm)
Comment
[
Correct
Commodity
Definition]

Page
6
of
39
Tolerances
Established
Under
40
CFR
§
180.410(
c)

Raspberry
2.0
2.0
No
change.

Residue
Data
used
for
Acute
and
Chronic
Dietary
Assessments
As
was
stated
above
the
residues
included
in
risk
assessment
includes
three
of
triadimefon's
metabolites,
triadimenol,
KWG
1323,
and
KWG
1342.
The
USDA
PDP
only
analyzed
for
triadimefon
while
only
sampling
for
triadimenol
in
a
small
number
of
samples
(
54
samples
for
pears,
52
samples
for
pineapples,
and
no
samples
for
grapes)
in
grapes,
pears,
and
pineapples;
however,
in
apples,
triadimefon
and
triadimenol
were
sampled.
Since
HED
concluded
that
triadimefon,
triadimenol,
KWG
1323,
and
KWG
1342
are
of
concern,
residue
data
for
other
metabolites
besides
triadimefon
were
needed
for
conducting
a
dietary
risk
assessment.

In
order
to
estimate
the
total
residues
of
triadimefon
and
all
its
metabolites,
the
concentration
of
triadimefon
and
all
its
metabolites
of
concern
(
termed
Total
Toxic
Residue
or
TTR)
were
used.
The
metabolism
study
conducted
with
grapes
was
used
based
on
the
similarities
to
all
the
supported
crops
and
the
fact
that
it
will
produce
a
more
conservative
assessment
than
using
the
cucumber
or
tomato
metabolism
studies.
To
calculate
the
TRR
in
PDP
monitoring
samples,
the
ratio
of
the
TTR
to
triadimefon
(
TTR:
triadimefon)
from
the
grape
metabolism
study
was
used
for
grapes,
pears,
and
pineapples.
The
ratio
of
the
TTR
to
triadimefon
and
triadimenol
(
TTR:
triadimefon
and
triadimenol)
was
used
for
apples
because
PDP
sampled
for
triadimefon
and
triadimenol
in
apples.

PDP
data
are
available
for
grapes,
pears,
and
pineapples,
however,
because
the
monitoring
data
analyzed
for
triadimefon
while
only
sampling
for
triadimenol
in
a
small
number
of
samples,
the
ratio
of
total
toxic
residues
(
TTR)
to
triadimefon
from
available
metabolism
studies
were
used
to
estimate
the
total
residues
of
concern.
This
presented
a
factor
of
70.7x,
which
would
produce
AR
estimates
that
are
overly
conservative.
Therefore,
grape
and
pineapple
field
trial
data
were
incorporated
into
the
assessment
and
apple
PDP
data
were
translated
to
pears.

The
anticipated
residue
estimates
for
apples
and
pears
are
based
on
apple
PDP
data.
As
noted
above,
monitoring
data
analyzed
for
triadimefon
and
triadimenol
and
not
KWG
1323
and
KWG
1342,
the
ratio
of
TTR
to
triadimefon
and
triadimenol
from
available
metabolism
studies
were
used
to
estimate
the
total
residues
of
concern.

All
triadimefon
acute
and
chronic
residue
estimates
for
crop
commodities
are
listed
in
Attachment
1.

Processing
Factors
Data
from
the
processing
studies
were
used
in
this
assessment
for
several
commodities
along
with
a
DEEM
7.81
default
processing
factors
for
dried
apple
(
8.0x),
dried
pear
(
6.25x),
and
dried
pineapple
(
5.0x).
Acceptable
processing
studies
are
available
for
apples,
grapes,
and
pineapple.
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A
processing
factor
of
0.6x
was
utilized
for
apple
juice
and
4.0x
for
raisin.
All
other
processed
commodities
showed
little
or
no
concentration
in
the
available
processing
studies.
For
detailed
considerations
of
processing
factors
see
"
Triadimefon.
Summary
of
Analytical
Chemistry
and
Residue
Data
for
the
Reregistration
Eligibility
Decision
(
RED)
Document"
under
guideline
section
860.1520
(
S.
Ary,
D314742,
11/
23/
2005).

Usage
Information
Dietary
risk
estimates
are
based,
in
part,
on
estimates
of
the
percent
usage
of
triadimefon
on
apples,
grapes,
pears,
pineapples,
and
raspberries.
BEAD
has
estimated
triadimefon
use
(
J.
Carter,
SLUA,
6/
2/
2005)
based
on
available
pesticide
survey
usage
data
for
the
years
1997
to
2003
(
Attachment
17).
BEAD
estimates
are
provided
to
HED
as
an
average
and
as
an
estimated
maximum.
In
addition
to
the
SLUA
(
Screening
Level
Usage
Analysis)
produced
by
BEAD
which
provided
usage
data
for
apples,
grapes,
pears,
and
raspberries;
Bayer
provided
survey
data
in
an
email
submission
to
John
Pates
on
9/
2/
2005.
Del
Monte,
Dole,
and
Maui
Pine
indicated
that
100%
of
all
pineapple
seeds
are
treated
and
100%
of
all
fresh
pineapples
are
treated.
The
estimated
maximum
%
CT
was
used
for
the
acute
dietary
risk
assessment
and
the
estimated
average
%
CT
was
used
for
the
chronic
dietary
risk
assessments.

Translation
of
Residue
Data
The
analyses
relied
on
translating
PDP
data
from
apples
to
pears.
The
HED
Standard
Operating
Procedure
(
SOP)
99.3
was
followed
during
translation
of
the
available
apple
PDP
data
to
pears.
The
mode
of
application,
label
rates,
preharvest
intervals,
percent
crop
treated,
tolerance
levels,
and
field
trial
residues
are
all
similar
between
apples
and
pears.

Residue
Estimates
for
Individual
Crops
The
following
presents
residue
data,
ratios
of
TTR:
triadimefon
and
triadimefon
from
metabolism
studies,
and
%
CT
estimates
that
were
used
in
the
dietary
analyses
for
individual
crops.

Apple:
PDP
data
from
2003
were
used
for
apples.
A
total
of
744
samples
were
analyzed
for
triadimefon
and
triadimenol.
Triadimefon
was
not
detected
in
any
samples
and
triadimenol
was
detected
in
14
samples.
The
ratio
of
TTR
(
77.8%)/
triadimefon
and
triadimenol
(
62.3%)
=
1.25
from
the
grape
metabolism
study
was
used
to
estimate
the
total
residues
of
concern
based
on
reported
triadimefon
and
triadimenol
residues
in
monitoring
samples.
The
estimated
maximum
%
CT
for
apples
of
10%
was
used
for
the
acute
dietary
risk
assessment
and
the
estimated
average
%
CT
of
5%
was
used
for
the
chronic
dietary
risk
assessments.

Grape:
Grape
field
trial
data
submitted
in
MRID
41809401
were
used.
A
total
of
seven
trials
were
conducted
and
samples
were
analyzed
for
triadimefon,
triadimenol,
KWG
1323,
and
KWG
1342.
The
method
LOQ
was
determined
at
0.01
ppm.
For
values
reported
below
the
LOQ,
half
the
LOQ
was
used
in
calculating
the
total
combined
residues
of
triadimefon,
triadimenol,
KWG
1323,
and
KWG
1342.
All
residue
values
were
corrected
to
1x
application
rate.
The
estimated
maximum
%
CT
for
grapes
of
5%
was
used
for
the
acute
dietary
risk
assessment
and
the
estimated
average
%
CT
of
1%
was
used
for
the
chronic
dietary
risk
assessments.
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Pear:
Apple
PDP
data
were
translated
to
pears.
The
estimated
maximum
%
CT
for
pears
of
5%
was
used
for
the
acute
dietary
risk
assessment
and
the
estimated
average
%
CT
of
5%
was
used
for
the
chronic
dietary
risk
assessments.

Pineapple:
Pineapple
field
trial
data
submitted
in
MRID
42342307
were
used.
A
total
of
ten
trials
were
conducted
and
samples
were
analyzed
for
triadimefon,
triadimenol,
KWG
1323,
and
KWG
1342.
The
method
LOQ
was
determined
at
0.01
ppm.
For
values
reported
below
the
LOQ,
half
the
LOQ
was
used
in
calculating
the
total
combined
residues
of
triadimefon,
triadimenol,
KWG
1323,
and
KWG
1342.
All
residue
values
were
corrected
to
1x
application
rate.
The
estimated
%
CT
for
pineapples
of
100%
was
used
for
the
acute
and
chronic
dietary
risk
assessments.

Raspberry:
No
PDP
data
are
available
for
raspberries,
so
the
available
field
trial
data
submitted
in
MRID
92188061
were
used.
A
total
of
twelve
trials
were
conducted
and
samples
were
analyzed
for
triadimefon,
triadimenol,
KWG
1323,
and
KWG
1342.
The
method
LOQ
was
determined
at
0.01
ppm.
For
values
reported
below
the
LOQ,
half
the
LOQ
was
used
in
calculating
the
total
combined
residues
of
triadimefon,
triadimenol,
KWG
1323,
and
KWG
1342.
All
residue
values
were
corrected
to
1x
application
rate.
The
estimated
average
%
CT
for
raspberries
of
50%
was
used
for
the
acute
and
chronic
dietary
risk
assessments.

III.
Drinking
Water
Data
The
drinking
water
values
used
in
the
dietary
risk
assessment
were
provided
by
the
Environmental
Fate
and
Effects
Division
(
EFED)
in
the
following
memorandum:
"
Tier
2
Drinking
Water
Assessment
for
Triadimefon
and
its
Major
Degradate
Triadimenol"
(
J.
Angier,
D316941,
8/
31/
2005).
Water
residues
were
incorporated
in
the
DEEM­
FCID
 
into
the
food
categories
"
water,
direct,
all
sources"
and
"
water,
indirect,
all
sources".

The
estimated
surface
drinking
water
concentrations
(
EDWCs)
for
triadimefon
and
triadimenol
were
moderately
refined
and
calculated
using
PRZM
(
Pesticide
Root
Zone
Model)
and
EXAMS
(
Exposure
Analysis
Modeling
System)
for
use
in
the
human
health
risk
assessment.
The
estimated
groundwater
concentrations
for
triadimefon
were
unrefined
and
calculated
using
SCI­
GROW
(
Screening
Concentration
In
Ground
Water),
however,
were
not
used
in
the
assessment
because
residues
are
shown
to
be
much
higher
in
surface
water.

The
EDWCs
were
calculated
from
the
Oregon
Christmas
tree,
Pennsylvania
apple,
and
Florida
turf
scenarios.
The
FL
turf
scenario
produced
the
highest
concentrations
and
is
used
in
this
dietary
assessment.
For
the
PRZM/
EXAMS
model,
some
initial
assumptions/
simplifications
were
made;
1)
total
residues
(
parent
triadimefon
plus
the
degradate
triadimenol)
are
treated
as
a
single
component
in
terms
of
fate
properties
(
half­
lives,
etc.),
with
most
of
the
parent
converting
to
the
degradate
of
concern
(
triadimenol)
which
is
generally
more
persistent
in
the
environment;
2)
for
total
residues,
an
application
depth
of
0
cm
is
assumed
to
reflect
surface
applications
(
in
this
case,
aerial
and
ground
spray);
3)
input
parameters
most
relevant
to
processes
that
occur
at
or
near
time
of
application
(
molecular
weight,
vapor
pressure,
solubility,
K
oc
,
and
photolysis)
are
used
to
reflect
the
characteristics
of
the
parent
alone
since
the
parent
is
the
predominant
form
available
at
the
surface
following
application,
and
these
values
are
nonetheless
very
close
to
those
for
triadimenol;
4)
other
inputs
that
are
relevant
to
transport,
fate,
and
persistence
of
compound
(
soil
and
water
half­
lives)
are
derived
from
characteristics
of
total
residues
(
parent
+
triadimenol);
5)
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the
aerobic
soil
half­
life
for
total
residues
(
triadimefon
+
triadimenol)
was
determined
to
be
240
days
and
the
aerobic
aquatic
half­
life
for
total
residues
of
concern
is
480
days;
6)
a
default
Percent
Cropped
Area
(
PCA)
factor
of
0.87
(
87%)
has
been
applied
to
all
the
scenarios;
and
7)
other
degradates
(
e.
g.,
CPMT
or
chlorophenoxymethyltriazole
or
4­
chlorophenoxy­
1,2,4­
triazol­
1­
ylmethane
are
not
considered
here
because
there
is
insufficient
data
on
the
specific
rates
and
locales
of
formation
and
conditions
under
which
formation
occurs
to
evaluate
tertiary
degradates
as
part
of
total
triadimefon
residues;
however,
based
on
current
information,
other
degradates
are
not
at
this
time
considered
to
be
essential
components
of
this
drinking
water
evaluation.

The
Florida
turf
assessment
represents
an
upper­
bound
for
potential
concentrations
since
the
total
number
of
applications
allowed
annually
is
undefined
on
the
label
(
assessment
is
based
on
the
upper­
bound
assumption
of
26
applications
per
year).
In
addition,
the
FL
turf
scenario
was
also
run
with
a
limited
number
of
applications.
As
requested
by
Bayer
CropScience
(
personal
communication),
a
total
of
three
applications
per
year
at
the
maximum
application
rate
for
turf
grass
(
3.026
kg/
ha)
with
14­
day
intervals
was
utilized
for
a
PRZM­
EXAMS
modeling
run.
This
presumably
represents
a
more
"
typical"
use
pattern
for
turf
applications.
The
results
of
this
limited
application
run
are
presented
here
simply
as
a
"
what­
if"
scenario
for
comparison
with
the
same
scenario
using
the
maximum
potential
number
of
annual
applications
(
26).
Since
there
is
no
information
on
the
label
to
indicate
a
limit
of
three
applications
per
year,
results
from
this
scenario
should
be
used
strictly
as
a
comparison
to
the
other
turf
scenario
with
26
applications.

There
remain
some
uncertainties
that,
if
addressed,
could
help
predict
potential
drinking
water
concerns.
Specifically,
additional
studies
elucidating
some
of
the
fate
parameters
would
lead
to
a
higher
level
of
confidence
in
the
accuracy
of
model
predictions.
These
include:
aerobic
soil
metabolism
studies,
currently
there
is
a
single
valid
study
on
which
the
aerobic
soil
half­
life
for
total
residues
(
triadimefon
+
triadimenol)
is
based;
aerobic
aquatic
metabolism
studies,
of
which
there
are
currently
none
(
2x
the
aerobic
soil
half­
life
is
used);
and
further
information
on
the
behavior
and
characteristics
of
some
of
the
other
degradates,
such
as
CPMT.

Acute
Dietary
Assessment
The
30
year
annual
peak
surface
water
distribution
of
concentrations
that
was
generated
using
the
maximum
allowable
number
of
applications
per
year
was
used
for
the
acute
dietary
assessment.
For
comparison,
the
estimated
surface
water
distribution
of
concentrations
using
a
typical
number
of
3
applications
per
year
was
incorporated
into
the
acute
dietary
exposure
assessment.

Chronic
Dietary
Assessment
The
1
in
10
year
annual
mean
surface
water
concentration
of
0.1467
ppm
was
used
for
the
chronic
dietary
assessment.
The
surface
water
concentration
was
generated
using
the
maximum
allowable
number
of
applications
per
year.
For
comparison,
the
estimated
surface
water
concentration
of
0.02498
ppm
was
used
in
the
chronic
dietary
assessment.
The
surface
water
concentration
represents
a
typical
number
of
3
applications
per
year.
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IV.
DEEM­
FCID
 
Program
and
Consumption
Information
Triadimefon
acute
and
chronic
dietary
exposure
assessments
were
conducted
using
the
Dietary
Exposure
Evaluation
Model
software
with
the
Food
Commodity
Intake
Database
(
DEEMFCID
 
,
Version
2.03),
which
incorporates
consumption
data
from
USDA's
Continuing
Surveys
of
Food
Intakes
by
Individuals
(
CSFII),
1994­
1996
and
1998.
The
1994­
96,
98
data
are
based
on
the
reported
consumption
of
more
than
20,000
individuals
over
two
non­
consecutive
survey
days.
Foods
"
as
consumed"
(
e.
g.,
apple
pie)
are
linked
to
EPA­
defined
food
commodities
(
e.
g.
apples,
peeled
fruit
­
cooked;
fresh
or
N/
S;
baked;
or
wheat
flour
­
cooked;
fresh
or
N/
S,
baked)
using
publicly
available
recipe
translation
files
developed
jointly
by
USDA/
ARS
and
EPA.
For
chronic
exposure
assessment,
consumption
data
are
averaged
for
the
entire
U.
S.
population
and
within
population
subgroups,
but
for
acute
exposure
assessment
are
retained
as
individual
consumption
events.
Based
on
analysis
of
the
1994­
96,
98
CSFII
consumption
data,
which
took
into
account
dietary
patterns
and
survey
respondents,
HED
concluded
that
it
is
most
appropriate
to
report
risk
for
the
following
population
subgroups:
the
general
U.
S.
population,
all
infants
(
less
than
1
year
old),
children
1­
2,
children
3­
5,
children
6­
12,
youth
13­
19,
adults
20­
49,
females
13­
49,
and
adults
50+
years
old.

For
chronic
dietary
exposure
assessment,
an
estimate
of
the
residue
level
in
each
food
or
foodform
(
e.
g.,
orange
or
orange
juice)
on
the
food
commodity
residue
list
is
multiplied
by
the
average
daily
consumption
estimate
for
that
food/
food
form
to
produce
a
residue
intake
estimate.
The
resulting
residue
intake
estimate
for
each
food/
food
form
is
summed
with
the
residue
intake
estimates
for
all
other
food/
food
forms
on
the
commodity
residue
list
to
arrive
at
the
total
average
estimated
exposure.
Exposure
is
expressed
in
mg/
kg
body
weight/
day
and
as
a
percent
of
the
cPAD.
This
procedure
is
performed
for
each
population
subgroup.

For
acute
exposure
assessments,
individual
one­
day
food
consumption
data
are
used
on
an
individual­
by­
individual
basis.
The
reported
consumption
amounts
of
each
food
item
can
be
multiplied
by
a
residue
point
estimate
and
summed
to
obtain
a
total
daily
pesticide
exposure
for
a
deterministic
exposure
assessment,
or
"
matched"
in
multiple
random
pairings
with
residue
values
and
then
summed
in
a
probabilistic
assessment.
The
resulting
distribution
of
exposures
is
expressed
as
a
percentage
of
the
aPAD
on
both
a
user
(
i.
e.,
only
those
who
reported
eating
relevant
commodities/
food
forms)
and
a
per­
capita
(
i.
e.,
those
who
reported
eating
the
relevant
commodities
as
well
as
those
who
did
not)
basis.
In
accordance
with
HED
policy,
per
capita
exposure
and
risk
are
reported
for
all
tiers
of
analysis.
However,
for
tiers
1
and
2,
any
significant
differences
in
user
vs.
per
capita
exposure
and
risk
are
specifically
identified
and
noted
in
the
risk
assessment.

V.
Toxicological
Information
A
summary
of
the
toxicological
doses
and
endpoints
selected
for
the
dietary
exposure
assessments
are
provided
in
Table
3.
Triadimefon
Dietary
Exposure
Assessment
­
RED
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Barcode:
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11
of
39
Table
3.
Summary
of
Toxicological
Doses
and
Endpoints
for
Triadimefon.
1,2
Exposure
Scenario
Dose
Used
in
Risk
Assessment,
UF
Special
FQPA
SF*
and
Level
of
Concern
for
Risk
Assessment
Study
and
Toxicological
Effects
Acute
Dietary
(
general
population)
NOAEL
=
10
mg/
kg/
day
UF
=
1000
Acute
RfD
=
0.01
mg/
kg/
day
FQPA
SF
=
1X
aPAD
=
acute
RfD
FQPA
SF
=
0.01
mg/
kg/
day
Developmental
toxicity
in
rats.
Maternal
LOAEL
=
25
mg/
kg/
day
based
on
dose­
related
increase
in
both
degree
and
duration
of
motor
activity.

Developmental
NOAEL
=
50
mg/
kg/
day.
Developmental
LOAEL
=
100
mg/
kg/
day
based
on
increased
incidences
of
cleft
palates;
two
fetuses
from
two
different
litters
were
found
to
have
cleft
palate.

Chronic
Dietary
(
all
populations)
NOAEL
=
3.4
mg/
kg/
day
UF
=
1000
Chronic
RfD
=
0.0034
mg/
kg/
day
FQPA
SF
=
1X
cPAD
=
chronic
RfD
FQPA
SF
=
0.0034
mg/
kg/
day
Subchronic
neurotoxicity
study
in
rats.
LOAEL
=
54.6/
68.7
mg/
kg/
day
based
largely
on
hyperactivity.

Cancer
(
oral,
dermal,
inhalation)
Classification:
Category
C
"
possible
human
carcinogen"
based
on
statistically
significant
increase
in
thyroid
adenomas
in
male
Wistar
rats
and
statistically
significant
increases
in
hepatocellular
adenomas
in
both
sexes
of
the
NMRI
mouse.

1.
Triadimefon.
Preliminary
Human
Health
Risk
Assessment.
PC
Code:
109901,
DP
Barcode:
D281838,
Case
No:
2700,
Regulatory
Action:
Phase
1
Reregistration,
Risk
Assessment
Type:
Single
Chemical
Aggregate.
2.
UF
=
uncertainty
factor,
FQPA
SF
=
Special
FQPA
safety
factor,
NOAEL
=
no
observed
adverse
effect
level,
LOAEL
=
lowest
observed
adverse
effect
level,
PAD
=
population
adjusted
dose
(
a
=
acute,
c
=
chronic)
RfD
=
reference
dose,
MOE
=
margin
of
exposure,
LOC
=
level
of
concern,
NA
=
Not
Applicable.

VI.
Results/
Discussion
As
stated
above,
for
acute
and
chronic
assessments,
HED
is
concerned
when
dietary
risk
exceeds
100%
of
the
PAD.
The
DEEM­
FCID
 
analyses
estimate
the
dietary
exposure
of
the
U.
S.
population
and
various
population
subgroups.
The
acute
dietary
exposure
analysis
results
reported
in
Table
4
are
for
the
general
U.
S.
population,
all
infants
(
less
than
1
year
old),
children
1­
2,
children
3­
5,
children
6­
12,
youth
13­
19,
adults
20­
49,
adults
50+
years,
and
females
13­
49.
The
chronic
dietary
exposure
analysis
results
reported
in
Table
5
are
for
the
general
U.
S.
population,
all
infants
(
less
than
1
year
old),
children
1­
2,
children
3­
5,
children
6­
12,
youth
13­
19,
adults
20­
49,
adults
50+
years,
and
females
13­
49.

Results
of
Acute
Dietary
Exposure
Analysis
This
assessment
concludes
that
for
all
supported
commodities,
the
acute
dietary
risk
estimates
exceed
HED's
level
of
concern
(
greater
than
100%
of
the
aPAD)
at
the
99.9th
exposure
percentile
for
the
U.
S.
population
(
840%
of
the
aPAD)
and
all
population
subgroups,
with
the
highest
exposed
population
subgroup
being
all
infants
less
than
one
year
old
at
2400%
of
the
aPAD.
The
results
of
the
acute
dietary
exposure
analysis
at
the
95th,
99th,
and
99.9th
percentiles
of
exposure
Triadimefon
Dietary
Exposure
Assessment
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are
reported
in
Table
4.
The
results
of
the
acute
dietary
exposure
analysis
at
the
99.9th
percentile
are
reported
in
Table
5
along
with
chronic
dietary
exposure
analyses
for
easy
comparison.

Table
4.
Results
of
Acute
Dietary
Exposure
Analysis
Using
DEEM­
FCID
(
Food
and
Water).

Population
Subgroup
aPAD
(
mg/
kg/
day)
95th
Percentile
99th
Percentile
99.9th
Percentile
Exposure
(
mg/
kg/
day)
%
aPAD*
Exposure
(
mg/
kg/
day)
%
aPAD*
Exposure
(
mg/
kg/
day)
%
aPAD*

General
U.
S.
Population
0.0034
0.006697
200
0.012952
380
0.028541
840
All
Infants
(<
1
year
old)
0.0034
0.024676
730
0.043671
1300
0.080231
2400
Children
1­
2
years
old
0.0034
0.010562
310
0.019460
570
0.037083
1100
Children
3­
5
years
old
0.0034
0.009547
280
0.017314
510
0.033309
980
Children
6­
12
years
old
0.0034
0.006613
190
0.012101
360
0.022809
670
Youth
13­
19
years
old
0.0034
0.005152
150
0.009947
290
0.021487
630
Adults
20­
49
years
old
0.0034
0.006224
180
0.011491
340
0.023236
680
Adults
50+
years
old
0.0034
0.006004
180
0.010068
300
0.018553
550
Females
13­
49
year
old
0.0034
0.006285
180
0.011485
340
0.022985
680
The
bolded
values
represent
the
highest
exposed
populations
for
each
percentile.

The
acute
dietary
risk
estimates
for
food
alone
(
no
water)
exceed
HED's
level
of
concern
at
the
99.9th
exposure
percentile
for
children
1­
2
years
old
at
240%
of
the
aPAD,
children
3­
5
years
old
at
170%.
The
acute
dietary
risk
estimate
does
not
exceed
HED's
level
of
concern
for
the
U.
S.
population
at
72%
of
the
aPAD.
The
results
of
the
food
alone
acute
dietary
exposure
analysis
at
the
99.9th
percentile
are
reported
in
Table
7
along
with
food
alone
chronic
dietary
exposure
analysis
for
easy
comparison.

For
comparison,
the
estimated
surface
water
distribution
of
concentrations
using
a
typical
number
of
3
applications
per
year
was
incorporated
into
the
acute
dietary
exposure
assessment.
For
all
supported
commodities,
the
acute
dietary
risk
estimates
exceed
HED's
level
of
concern
at
the
99.9th
exposure
percentile
for
the
U.
S.
population
(
230%
of
the
aPAD)
and
all
population
subgroups,
with
the
highest
exposed
population
subgroup
being
all
infants
less
than
one
year
old
at
710%
of
the
aPAD.
The
results
of
the
acute
dietary
exposure
analysis
at
the
99.9th
percentile
are
reported
in
Table
6
along
with
chronic
dietary
exposure
analyses
for
easy
comparison.

Results
of
Chronic
Dietary
Exposure
Analysis
This
assessment
concludes
that
for
all
supported
commodities,
the
chronic
dietary
risk
estimates
exceed
HED's
level
of
concern
(
greater
than
100%
of
the
cPAD)
for
all
infants
less
than
one
year
old
at
300%
of
the
cPAD,
children
1­
2
years
old
at
140%
of
the
cPAD,
and
children
3­
5
years
old
at
130%
of
the
cPAD.
The
chronic
dietary
risk
estimate
does
not
exceed
HED's
level
of
concern
(
less
than
100%
of
the
cPAD)
for
the
U.
S.
population
at
91%
of
the
cPAD.
The
results
of
the
chronic
dietary
exposure
analysis
are
reported
below
in
Table
5.
Triadimefon
Dietary
Exposure
Assessment
­
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Barcode:
314778
Page
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of
39
Table
5.
Summary
of
Dietary
Exposure
and
Risk
for
Triadimefon
(
Food
and
Water).

Population
Subgroup
Acute
Dietary
(
99.9th
Percentile)
Chronic
Dietary
Exposure
(
mg/
kg/
day)
%
aPAD
Exposure
(
mg/
kg/
day)
%
cPAD
General
U.
S.
Population
0.028541
840
0.003092
93
All
Infants
(<
1
year
old)
0.080231
2400
0.010137
300
Children
1­
2
years
old
0.037083
1100
0.004592
140
Children
3­
5
years
old
0.033309
980
0.004299
130
Children
6­
12
years
old
0.022809
670
0.002965
87
Youth
13­
19
years
old
0.021487
630
0.002235
66
Adults
20­
49
years
old
0.023236
680
0.002887
85
Adults
50+
years
old
0.018553
550
0.003037
89
Females
13­
49
years
old
0.022985
680
0.002875
85
The
bolded
values
represent
the
highest
exposed
populations
for
each
of
the
risk
assessments.

For
comparison,
the
estimated
surface
water
concentration
using
a
typical
number
of
3
applications
per
year
was
incorporated
into
the
chronic
dietary
exposure
assessment.
For
all
supported
commodities,
the
chronic
dietary
risk
estimates
do
not
exceed
HED's
level
of
concern
for
the
U.
S.
population
(
16%
of
the
cPad)
and
all
population
subgroups,
with
the
highest
exposed
population
subgroup
being
all
infants
less
than
one
year
old
at
52%
of
the
cPad.
The
results
of
the
chronic
dietary
exposure
analysis
are
reported
below
in
Table
6.

Table
6.
Summary
of
Dietary
Exposure
and
Risk
for
Triadimefon
Using
Surface
Water
that
was
Calculated
with
3
Applications
Per
Year
(
Food
and
Water).

Population
Subgroup
Acute
Dietary
(
99.9th
Percentile)
Chronic
Dietary
Exposure
(
mg/
kg/
day)
%
aPAD
Exposure
(
mg/
kg/
day)
%
cPAD
General
U.
S.
Population
0.007654
230
0.000542
16
All
Infants
(<
1
year
old)
0.024253
710
0.001755
52
Children
1­
2
years
old
0.012677
370
0.000845
25
Children
3­
5
years
old
0.010709
310
0.000779
23
Children
6­
12
years
old
0.006946
200
0.000529
16
Youth
13­
19
years
old
0.005649
170
0.000390
12
Adults
20­
49
years
old
0.006565
190
0.000501
15
Adults
50+
years
old
0.005836
170
0.000529
16
Females
13­
49
years
old
0.006548
190
0.000500
15
The
bolded
values
represent
the
highest
exposed
populations
for
each
of
the
risk
assessments.
Triadimefon
Dietary
Exposure
Assessment
­
RED
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Barcode:
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14
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39
The
chronic
dietary
risk
estimates
for
food
alone
(
no
water)
do
not
exceed
HED's
level
of
concern
for
the
U.
S.
population
(
less
than
1%
of
the
cPad)
and
all
population
subgroups,
with
the
highest
exposed
population
subgroup
being
children
1­
2
years
old
at
2%
of
the
cPAD.
The
results
of
the
food
alone
chronic
dietary
exposure
analysis
are
reported
below
in
Table
7
along
with
food
alone
acute
dietary
exposure
analysis
at
the
99.9th
percentile
for
easy
comparison.

Table
7.
Summary
of
Dietary
Exposure
and
Risk
for
Triadimefon
(
Food
Only).

Population
Subgroup
Acute
Dietary
(
99.9th
Percentile)
Chronic
Dietary
Exposure
(
mg/
kg/
day)
%
aPAD
Exposure
(
mg/
kg/
day)
%
cPAD
General
U.
S.
Population
0.002442
72
0.000015
<
1
All
Infants
(<
1
year
old)
0.003239
95
0.000029
1
Children
1­
2
years
old
0.008249
240
0.000063
2
Children
3­
5
years
old
0.005862
170
0.000047
1
Children
6­
12
years
old
0.003064
90
0.000025
1
Youth
13­
19
years
old
0.001581
47
0.000009
<
1
Adults
20­
49
years
old
0.001797
53
0.000010
<
1
Adults
50+
years
old
0.001831
54
0.000011
<
1
Females
13­
49
years
old
0.001930
57
0.000011
<
1
The
bolded
values
represent
the
highest
exposed
populations
for
each
percentile.

VII.
Characterization
of
Inputs/
Outputs
The
acute
and
chronic
dietary
exposure
assessments
were
refined
through
the
use
of
experimentally
determined
processing
factors,
DEEM
7.81
default
processing
factors,
and
percent
crop
treated
estimates
provided
by
BEAD.
The
anticipated
residue
estimates
are
based
on
USDA
PDP
monitoring
data
and
field
trial
data.
However,
because
monitoring
data
did
not
analyze
for
all
triadimefon
metabolites
of
concern,
the
ratio
of
total
toxic
residues
(
TTR)
to
triadimefon
from
available
metabolism
studies
were
used
to
estimate
the
total
residues
of
concern.
The
metabolism
study
conducted
with
grapes
was
used
based
on
the
similarities
to
all
the
supported
crops
and
the
fact
that
it
will
produce
a
more
conservative
assessment
than
using
the
cucumber
or
tomato
metabolism
studies.
HED
concludes
that
the
exposure
estimates
provided
in
this
document
are
unlikely
to
underestimate
actual
exposure.

VIII.
Conclusions
Acute
and
chronic
dietary
(
food
and
water)
exposure
assessments
were
conducted
using
the
Dietary
Exposure
Evaluation
Model
software
with
the
Food
Commodity
Intake
Database
(
DEEM­
FCID
 
,
Version
2.03),
which
uses
food
consumption
data
from
the
USDA's
Continuing
Surveys
of
Food
Intakes
by
Individuals
(
CSFII)
from
1994­
1996
and
1998.
The
acute
and
chronic
dietary
risk
assessments
were
conducted
for
all
supported
triadimefon
food
uses
and
were
performed
to
support
the
reregistration
eligibility
decision
document.
Triadimefon
Dietary
Exposure
Assessment
­
RED
DP
Barcode:
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Page
15
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39
This
assessment
concludes
that
for
all
supported
commodities,
the
acute
dietary
risk
estimates
exceed
HED's
level
of
concern
(
greater
than
100%
of
the
aPAD)
at
the
99.9th
exposure
percentile
for
the
U.
S.
population
(
840%
of
the
aPAD)
and
all
population
subgroups,
with
the
highest
exposed
population
subgroup
being
all
infants
less
than
one
year
old
at
2400%
of
the
aPAD.
The
significant
acute
risk
contributors
have
been
identified
as
water
(
direct
and
indirect,
all
sources),
grape
juice,
pineapple
juice,
raisins,
and
fresh
grapes.

This
assessment
concludes
that
for
all
supported
commodities,
the
chronic
dietary
risk
estimates
exceed
HED's
level
of
concern
(
greater
than
100%
of
the
cPAD)
for
all
infants
less
than
one
year
old
at
300%
of
the
cPAD,
children
1­
2
years
old
at
140%
of
the
cPAD,
and
children
3­
5
years
old
at
130%
of
the
cPAD.
The
chronic
dietary
risk
estimate
does
not
exceed
HED's
level
of
concern
(
less
than
100%
of
the
cPAD)
for
the
U.
S.
population
at
91%
of
the
cPAD.
The
significant
chronic
risk
contributors
have
been
identified
as
water
(
direct
and
indirect,
all
sources).

The
acute
and
chronic
assessments
show
that
dietary
exposure
and
risk
are
of
concern
for
the
supported
uses.
Refinements
may
be
possible
in
the
future
with
additional
food
monitoring
data
that
samples
for
all
residues
of
concern
which
may,
in
turn,
lower
dietary
exposure
and
risk
from
food.
However,
no
additional
data
are
available
at
this
time
to
further
refine
the
dietary
risk
estimates
to
triadimefon.
Additionally,
the
estimated
drinking
water
concentrations
used
in
this
assessment
are
calculated
using
26
applications
per
year
to
turf,
which
may
be
overly
conservative
because
Bayer
has
indicated
the
typical
application
rate
to
be
3
applications
per
year.

IX.
List
of
Attachments
Attachment
1.
Data
and
Residue
Estimates
Used
in
Dietary
Analyses.
Attachment
2.
Residue
Distribution
Files
Used
for
Acute
Analyses.
Attachment
3.
Acute
Food
and
Surface
Water
Residue
Input
File.
Attachment
4.
Acute
Food
and
Surface
Water
Results
File.
Attachment
5.
Acute
Food
and
Surface
Water
Critical
Exposure
Contribution
Analysis
Attachment
6.
Acute
Food
Only
Results
File.
Attachment
7.
Acute
Food
Only
Critical
Exposure
Contribution
Analysis.
Attachment
8.
Acute
Water
Only
Results
File.
Attachment
9.
Acute
Water
Only
(
3
Applications
Per
Year)
Results
File.
Attachment
10.
Acute
Food
and
Surface
Water
(
3
Applications
Per
Year)
Results
File.
Attachment
11.
Chronic
Food
and
Surface
Water
Residue
Input
File.
Attachment
12.
Chronic
Food
and
Surface
Water
Results
File.
Attachment
13.
Chronic
Food
and
Surface
Water
Critical
Exposure
Contribution
Analysis.
Attachment
14.
Chronic
Food
Only
Results
File.
Attachment
15.
Chronic
Water
Only
Results
File.
Attachment
16.
Chronic
Food
and
Surface
Water
(
3
Application
Per
Year)
Results
File.
Attachment
17.
Usage
Report
in
Support
of
Reregistration
for
Triadimefon.
Triadimefon
Dietary
Exposure
Assessment
­
RED
DP
Barcode:
314778
Page
16
of
39
Attachment
1.
Data
and
Residue
Estimates
Used
in
Dietary
Analyses.

RAC
Classification1
Data
Source
Years
No.
of
Samples
No.
of
Detectable
Residues
Avg.
LOD
(
ppm)
%
CT
Avg.
2
%
CT
Max.
2
Processing
Factors3
Anticipated
Residue
Estimates/
Tolerance
Acute
(
Tol.,
AR,

RDF)
6
Chronic
and
Cancer
(
Tol.,
AR)

Apple
NB
or
PB
PDP
(
1.25x
factor)
2003
744
14
0.001
5
10
Juice
at
0.6x
RDF
1
TOTALZ=
670
TOTALLOD=
60
LODRES=
0.00063
AR
(
0.00010)

Apple
B
PDP
(
1.25x
factor)
2003
744
14
0.001
5
10
Dried
at
8x
RDF
2
TOTALZ=
0
TOTALLOD=
730
LODRES=
0.00063
AR
(
0.00010)

Grape
PB
Field
trial
data
(
MRID
41809401)
1991
7
7
0.01
1
5
Raisin
at
4x
RDF
3
TOTALZ=
140
TOTALLOD=
0
LODRES=
0.005
AR
(
0.0026)

Pear
NB
of
PB
Apple
PDP
data
2003
744
14
0.001
5
5
Dried
at
6.25x
RDF
4
TOTALZ=
707
TOTALLOD=
23
LODRES=
0.00063
AR
(
0.00010)

Pineapple
NB
or
PB
Field
trial
data
(
MRID
42342307)
1992
10
10
0.01
100
100
Dried
at
5.0
RDF
5
TOTALZ=
0
TOTALLOD=
0
LODRES=
0.005
AR
(
0.079)

Raspberry
PB
Field
trail
data
(
MRID
92188061)
1990
12
12
0.01
50
50
None
RDF
6
TOTALZ=
12
TOTALLOD=
0
LODRES=
0.005
AR
(
0.51)

Water
N/
A
EDWCs4
N/
A
N/
A
N/
A
N/
A
N/
A
N/
A
N/
A
RDF
7
Surface
water
distribution
Surface
water
0.1467
(
26
apps.)

0.02498
(
3
apps.)

1.
Classification
of
blended
(
B),
partially
blended
(
PB),
not
blended
(
NB).

2.
See
Chemistry
Summary
Document
under
guideline
section
860.1520
Processed
Food
and
Feed
for
details
(
S.
Ary,
D314742,
10/
28/
2005).

4.
EDWCs
=
Estimated
Drinking
Water
Concentrations.

5.
N/
A
=
Not
applicable.

6.
The
LOD
used
in
the
acute
and
chronic
AR
calculations
was
multiplied
by
a
factor
to
account
for
all
residues
and
then
divided
by
2.
For
example,
the
apple
acute
LODRES
was
calculated
as
follows:
(
0.001
x
1.25)/
2
=
0.00063.

Attachment
2.
Residue
Distribution
Files
Used
for
Acute
Analyses.
Triadimefon
Dietary
Exposure
Assessment
­
RED
DP
Barcode:
314778
Page
17
of
39
"
Apple,
B,
10%
CT
(
2003
PDP)"
TOTALZ=
0
TOTALLOD=
730
LODRES=
0.00063
0.0073
0.0056
7,0.005
0.0038
4,0.0025
"
Apple,
NB
or
PB,
10%
CT
(
2003
PDP)"
TOTALZ=
670
TOTALLOD=
60
LODRES=
0.00063
0.0073
0.0056
7,0.005
0.0038
4,0.0025
"
Grape,
PB,
5%
CT
(
Field
trial
data,
MRID
41809401)"
TOTALZ=
140
TOTALLOD=
0
LODRES=
0.005
0.22
0.46
0.07
0.03
0.45
0.49
0.12
"
Pear,
NB
or
PB,
5%
CT
(
2003
Apple
PDP
data)"
TOTALZ=
707
TOTALLOD=
23
LODRES=
0.00063
0.0073
0.0056
7,0.005
0.0038
4,0.0025
Triadimefon
Dietary
Exposure
Assessment
­
RED
DP
Barcode:
314778
Page
18
of
39
"
Pineapple,
NB
or
PB,
100%
CT
(
Field
trial
data,
MRID
42342307)"
TOTALZ=
0
TOTALLOD=
0
LODRES=
0.005
0.05
0.08
0.10
0.10
0.11
0.08
0.09
0.06
0.07
0.05
"
Raspberry,
PB,
50%
CT
(
Field
trail
data,
MRID
92188061)"
TOTALZ=
12
TOTALLOD=
0
LODRES=
0.005
1.59
1.50
1.11
1.26
0.79
0.85
0.77
0.93
0.73
1.65
0.66
0.46
Triadimefon
Dietary
Exposure
Assessment
­
RED
DP
Barcode:
314778
Page
19
of
39
Attachment
3.
Acute
Food
and
Surface
Water
Residue
Input
File.

U.
S.
Environmental
Protection
Agency
Ver.
2.02
DEEM­
FCID
Acute
analysis
for
TRIADIMEFON
Residue
file
name:
C:\
Pesticides\
Triadimefon\
Dietary\
Acute\
Triadimefon
acute.
R98
Analysis
Date
11­
16­
2005
Residue
file
dated:
11­
14­
2005/
18:
38:
27/
8
Reference
dose
(
aRfD)
=
0.0034
mg/
kg
bw/
day
Comment:
Food
and
Water
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
RDL
indices
and
parameters
for
Monte
Carlo
Analysis:
Index
Dist
Parameter
#
1
Param
#
2
Param
#
3
Comment
#
Code
­­­­­
­­­­
­­­­­­­­­­­­
­­­­­­­­­­­
­­­­­­­­­­­
­­­­­­­­­­
1
6
C:\
Pesticides\
Triadimefon\
Dietary\
RDF\
Apple,
NB
or
PB.
rdf
2
6
C:\
Pesticides\
Triadimefon\
Dietary\
RDF\
Apple,
B.
rdf
3
6
C:\
Pesticides\
Triadimefon\
Dietary\
RDF\
Grape,
PB.
rdf
4
6
C:\
Pesticides\
Triadimefon\
Dietary\
RDF\
Pear,
NB
or
PB.
rdf
5
6
C:\
Pesticides\
Triadimefon\
Dietary\
RDF\
Pineapple,
NB
or
PB.
rdf
6
6
C:\
Pesticides\
Triadimefon\
Dietary\
RDF\
Raspberry,
PB.
rdf
7
6
C:\
Pesticides\
Triadimefon\
Dietary\
RDF\
FL
Turf
Raw
Surface
Water
(
26
applications).
rdf
EPA
Crop
Food
Name
Def
Res
Adj.
Factors
RDL
Comment
Code
Grp
(
ppm)
#
1
#
2
Pntr
­­­­­­­­
­­­­
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­
­­­­­­
­­­­­­
­­­
­­­­­­
­
11000070
11
Apple,
fruit
with
peel
0.200000
1.000
1.000
1
11000080
11
Apple,
peeled
fruit
0.200000
1.000
1.000
1
11000081
11
Apple,
peeled
fruit­
babyfood
0.200000
1.000
1.000
1
11000090
11
Apple,
dried
0.200000
8.000
1.000
2
11000091
11
Apple,
dried­
babyfood
0.200000
8.000
1.000
2
11000100
11
Apple,
juice
0.200000
0.600
1.000
1
11000101
11
Apple,
juice­
babyfood
0.200000
0.600
1.000
1
11000110
11
Apple,
sauce
0.200000
1.000
1.000
1
11000111
11
Apple,
sauce­
babyfood
0.200000
1.000
1.000
1
95001750
O
Grape
1.000000
1.000
1.000
3
95001760
O
Grape,
juice
1.000000
1.000
1.000
3
95001761
O
Grape,
juice­
babyfood
1.000000
1.000
1.000
3
95001770
O
Grape,
leaves
1.000000
1.000
1.000
3
95001780
O
Grape,
raisin
2.500000
4.000
1.000
3
95001790
O
Grape,
wine
and
sherry
1.000000
1.000
1.000
3
11002660
11
Pear
0.200000
1.000
1.000
4
11002661
11
Pear­
babyfood
0.200000
1.000
1.000
4
11002670
11
Pear,
dried
0.200000
6.250
1.000
4
11002680
11
Pear,
juice
0.200000
1.000
1.000
4
11002681
11
Pear,
juice­
babyfood
0.200000
1.000
1.000
4
95002790
O
Pineapple
2.000000
1.000
1.000
5
95002791
O
Pineapple­
babyfood
2.000000
1.000
1.000
5
95002800
O
Pineapple,
dried
2.000000
5.000
1.000
5
95002810
O
Pineapple,
juice
2.000000
1.000
1.000
5
95002811
O
Pineapple,
juice­
babyfood
2.000000
1.000
1.000
5
13013200
13A
Raspberry
2.000000
1.000
1.000
6
13013201
13A
Raspberry­
babyfood
2.000000
1.000
1.000
6
13013210
13A
Raspberry,
juice
2.000000
1.000
1.000
6
13013211
13A
Raspberry,
juice­
babyfood
2.000000
1.000
1.000
6
86010000
O
Water,
direct,
all
sources
0.348300
1.000
1.000
7
86020000
O
Water,
indirect,
all
sources
0.348300
1.000
1.000
7
Triadimefon
Dietary
Exposure
Assessment
­
RED
DP
Barcode:
314778
Page
20
of
39
Attachment
4.
Acute
Food
and
Surface
Water
Results
File.

U.
S.
Environmental
Protection
Agency
Ver.
2.02
DEEM­
FCID
ACUTE
Analysis
for
TRIADIMEFON
(
1994­
98
data)
Residue
file:
Triadimefon
acute.
R98
Adjustment
factor
#
2
used.
Analysis
Date:
11­
16­
2005/
17:
48:
58
Residue
file
dated:
11­
14­
2005/
18:
38:
27/
8
Daily
totals
for
food
and
foodform
consumption
used.
MC
iterations
=
1000
MC
list
in
residue
file
MC
seed
=
1
Run
Comment:
"
Food
and
Water"
===============================================================================

Summary
calculations
(
per
capita):

95th
Percentile
99th
Percentile
99.9th
Percentile
Exposure
%
aRfD
Exposure
%
aRfD
Exposure
%
aRfD
­­­­­­­­­­
­­­­­­­­
­­­­­­­­­­
­­­­­­­­
­­­­­­­­­­
­­­­­­­­
U.
S.
Population:
0.006697
196.98
0.012952
380.94
0.028541
839.43
All
infants:
0.024676
725.75
0.043671
1284.45
0.080231
2359.73
Children
1­
2
yrs:
0.010562
310.65
0.019460
572.37
0.037083
1090.68
Children
3­
5
yrs:
0.009547
280.78
0.017314
509.24
0.033309
979.69
Children
6­
12
yrs:
0.006613
194.50
0.012101
355.90
0.022809
670.86
Youth
13­
19
yrs:
0.005152
151.53
0.009947
292.55
0.021487
631.97
Adults
20­
49
yrs:
0.006224
183.06
0.011491
337.98
0.023236
683.41
Adults
50+
yrs:
0.006004
176.59
0.010068
296.12
0.018553
545.67
Females
13­
49
yrs:
0.006285
184.85
0.011485
337.79
0.022985
676.04
Triadimefon
Dietary
Exposure
Assessment
­
RED
DP
Barcode:
314778
Page
21
of
39
Attachment
5.
Acute
Food
and
Surface
Water
Critical
Exposure
Contribution
Analysis.

U.
S.
Environmental
Protection
Agency
DEEM­
FCID
Acute
Critical
Exposure
Contribution
Analysis
(
Ver
2.02)
CSFII
1994­
98
Residue
file
=
C:\
Pesticides\
Triadimefon\
Dietary\
Acute\
Triadimefon
acute.
R98
Date
and
time
of
analysis:
11­
16­
2005
17:
42:
38
Daily
totals
for
food
and
foodform
consumption
used.
Adjustment
factor
#
2
used.
Minimum
exposure
contribution
=
1%
Monte
Carlo
Iterations
=
1000
Seed
=
1
CEC
records
generated
for
first
98
iterations.
Exposures
divided
by
body
weight
================================================================================
U.
S.
Population
Low
percentile
for
CEC
records:
99
Exposure
(
mg/
day)
=
0.012952
High
percentile
for
CEC
records:
100
Exposure
(
mg/
day)
=
0.375864
Number
of
actual
records
in
this
interval:
99679
Critical
foods/
foodforms
for
this
population
(
as
derived
from
these
records):
N=
number
of
appearances
in
all
records
(
including
duplicates)
%=
percent
of
total
exposure
for
all
records
(
including
duplicates)

Food
FF
N
Percent
Food
Name
­­­­­­­­
­­­
­­­­­
­­­­­­­
­­­­­­­­­­­­­
86020000
130
43062
35.94%
Water,
indirect,
all
sources­
Uncooked;
Dried;
Cook
Meth
N/
S
86010000
110
70933
35.76%
Water,
direct,
all
sources­
Uncooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
86020000
240
13350
10.38%
Water,
indirect,
all
sources­
Cooked;
Canned;
Cook
Meth
N/
S
86020000
230
16463
6.58%
Water,
indirect,
all
sources­
Cooked;
Dried;
Cook
Meth
N/
S
86020000
232
28358
5.82%
Water,
indirect,
all
sources­
Cooked;
Dried;
Boiled
86020000
110
13517
2.67%
Water,
indirect,
all
sources­
Uncooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
86020000
212
10719
1.00%
Water,
indirect,
all
sources­
Cooked;
Fresh
or
N/
S;
Boiled
86020000
120
4588
0.67%
Water,
indirect,
all
sources­
Uncooked;
Frozen;
Cook
Meth
N/
S
95001760
110
478
0.27%
Grape,
juice­
Uncooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
86020000
210
5464
0.22%
Water,
indirect,
all
sources­
Cooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
95001760
240
382
0.08%
Grape,
juice­
Cooked;
Canned;
Cook
Meth
N/
S
86020000
215
1631
0.06%
Water,
indirect,
all
sources­
Cooked;
Fresh
or
N/
S;
Boiled/
baked
86020000
211
2440
0.06%
Water,
indirect,
all
sources­
Cooked;
Fresh
or
N/
S;
Baked
95001780
130
148
0.05%
Grape,
raisin­
Uncooked;
Dried;
Cook
Meth
N/
S
95002810
110
656
0.05%
Pineapple,
juice­
Uncooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
95001761
240
173
0.05%
Grape,
juice­
babyfood­
Cooked;
Canned;
Cook
Meth
N/
S
86020000
242
483
0.04%
Water,
indirect,
all
sources­
Cooked;
Canned;
Boiled
95001750
110
196
0.04%
Grape­
Uncooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
86020000
213
1102
0.03%
Water,
indirect,
all
sources­
Cooked;
Fresh
or
N/
S;
Fried
13013200
240
796
0.03%
Raspberry­
Cooked;
Canned;
Cook
Meth
N/
S
13013210
110
64
0.03%
Raspberry,
juice­
Uncooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
95002810
240
1060
0.02%
Pineapple,
juice­
Cooked;
Canned;
Cook
Meth
N/
S
95001760
120
21
0.01%
Grape,
juice­
Uncooked;
Frozen;
Cook
Meth
N/
S
95002811
240
715
0.01%
Pineapple,
juice­
babyfood­
Cooked;
Canned;
Cook
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­
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Meth
N/
S
13013200
120
29
0.01%
Raspberry­
Uncooked;
Frozen;
Cook
Meth
N/
S
95002790
240
333
0.01%
Pineapple­
Cooked;
Canned;
Cook
Meth
N/
S
13013201
240
260
0.01%
Raspberry­
babyfood­
Cooked;
Canned;
Cook
Meth
N/
S
13013200
110
166
0.01%
Raspberry­
Uncooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
86020000
233
143
0.00%
Water,
indirect,
all
sources­
Cooked;
Dried;
Fried
95001780
230
65
0.00%
Grape,
raisin­
Cooked;
Dried;
Cook
Meth
N/
S
95001790
110
33
0.00%
Grape,
wine
and
sherry­
Uncooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
13013211
240
67
0.00%
Raspberry,
juice­
babyfood­
Cooked;
Canned;
Cook
Meth
N/
S
95002790
110
70
0.00%
Pineapple­
Uncooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
13013200
211
31
0.00%
Raspberry­
Cooked;
Fresh
or
N/
S;
Baked
95002791
240
81
0.00%
Pineapple­
babyfood­
Cooked;
Canned;
Cook
Meth
N/
S
95002810
120
45
0.00%
Pineapple,
juice­
Uncooked;
Frozen;
Cook
Meth
N/
S
95001780
211
34
0.00%
Grape,
raisin­
Cooked;
Fresh
or
N/
S;
Baked
86020000
214
38
0.00%
Water,
indirect,
all
sources­
Cooked;
Fresh
or
N/
S;
Fried/
baked
95001750
210
27
0.00%
Grape­
Cooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
95002790
211
43
0.00%
Pineapple­
Cooked;
Fresh
or
N/
S;
Baked
95001780
210
9
0.00%
Grape,
raisin­
Cooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
95001750
240
19
0.00%
Grape­
Cooked;
Canned;
Cook
Meth
N/
S
95001760
210
16
0.00%
Grape,
juice­
Cooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
13013210
240
11
0.00%
Raspberry,
juice­
Cooked;
Canned;
Cook
Meth
N/
S
11000101
240
4
0.00%
Apple,
juice­
babyfood­
Cooked;
Canned;
Cook
Meth
N/
S
95002790
210
5
0.00%
Pineapple­
Cooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
86020000
223
3
0.00%
Water,
indirect,
all
sources­
Cooked;
Frozen;
Fried
95001790
210
2
0.00%
Grape,
wine
and
sherry­
Cooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
11000111
240
2
0.00%
Apple,
sauce­
babyfood­
Cooked;
Canned;
Cook
Meth
N/
S
95001780
212
1
0.00%
Grape,
raisin­
Cooked;
Fresh
or
N/
S;
Boiled
11000100
110
2
0.00%
Apple,
juice­
Uncooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
11000100
240
1
0.00%
Apple,
juice­
Cooked;
Canned;
Cook
Meth
N/
S
95001790
213
1
0.00%
Grape,
wine
and
sherry­
Cooked;
Fresh
or
N/
S;
Fried
11000070
110
1
0.00%
Apple,
fruit
with
peel­
Uncooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
================================================================================
All
infants
Low
percentile
for
CEC
records:
99
Exposure
(
mg/
day)
=
0.043671
High
percentile
for
CEC
records:
100
Exposure
(
mg/
day)
=
0.375864
Number
of
actual
records
in
this
interval:
2813
Critical
foods/
foodforms
for
this
population
(
as
derived
from
these
records):
N=
number
of
appearances
in
all
records
(
including
duplicates)
%=
percent
of
total
exposure
for
all
records
(
including
duplicates)

Food
FF
N
Percent
Food
Name
­­­­­­­­
­­­
­­­­­
­­­­­­­
­­­­­­­­­­­­­
86020000
130
2053
64.67%
Water,
indirect,
all
sources­
Uncooked;
Dried;
Cook
Meth
N/
S
86010000
110
1697
12.41%
Water,
direct,
all
sources­
Uncooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
86020000
240
443
10.87%
Water,
indirect,
all
sources­
Cooked;
Canned;
Cook
Meth
N/
S
86020000
230
337
8.76%
Water,
indirect,
all
sources­
Cooked;
Dried;
Cook
Meth
N/
S
86020000
110
383
2.67%
Water,
indirect,
all
sources­
Uncooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
86020000
232
79
0.18%
Water,
indirect,
all
sources­
Cooked;
Dried;
Boiled
86020000
212
78
0.17%
Water,
indirect,
all
sources­
Cooked;
Fresh
or
N/
S;
Boiled
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95001761
240
7
0.10%
Grape,
juice­
babyfood­
Cooked;
Canned;
Cook
Meth
N/
S
86020000
120
20
0.09%
Water,
indirect,
all
sources­
Uncooked;
Frozen;
Cook
Meth
N/
S
86020000
242
7
0.02%
Water,
indirect,
all
sources­
Cooked;
Canned;
Boiled
95002810
110
12
0.02%
Pineapple,
juice­
Uncooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
86020000
210
8
0.01%
Water,
indirect,
all
sources­
Cooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
86020000
215
6
0.01%
Water,
indirect,
all
sources­
Cooked;
Fresh
or
N/
S;
Boiled/
baked
95001760
110
1
0.00%
Grape,
juice­
Uncooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
86020000
211
8
0.00%
Water,
indirect,
all
sources­
Cooked;
Fresh
or
N/
S;
Baked
95001760
240
1
0.00%
Grape,
juice­
Cooked;
Canned;
Cook
Meth
N/
S
86020000
213
3
0.00%
Water,
indirect,
all
sources­
Cooked;
Fresh
or
N/
S;
Fried
95001780
230
1
0.00%
Grape,
raisin­
Cooked;
Dried;
Cook
Meth
N/
S
95002810
240
1
0.00%
Pineapple,
juice­
Cooked;
Canned;
Cook
Meth
N/
S
95002811
240
1
0.00%
Pineapple,
juice­
babyfood­
Cooked;
Canned;
Cook
Meth
N/
S
Triadimefon
Dietary
Exposure
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­
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DP
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Attachment
6.
Acute
Food
Only
Results
File.

U.
S.
Environmental
Protection
Agency
Ver.
2.02
DEEM­
FCID
ACUTE
Analysis
for
TRIADIMEFON
(
1994­
98
data)
Residue
file:
Triadimefon
acute
(
food
only).
R98
Adjustment
factor
#
2
used.
Analysis
Date:
11­
16­
2005/
18:
08:
46
Residue
file
dated:
11­
14­
2005/
17:
51:
21/
8
Daily
totals
for
food
and
foodform
consumption
used.
MC
iterations
=
1000
MC
list
in
residue
file
MC
seed
=
1
Run
Comment:
"
Food
Only"
===============================================================================

Summary
calculations
(
per
capita):

95th
Percentile
99th
Percentile
99.9th
Percentile
Exposure
%
aRfD
Exposure
%
aRfD
Exposure
%
aRfD
­­­­­­­­­­
­­­­­­­­
­­­­­­­­­­
­­­­­­­­
­­­­­­­­­­
­­­­­­­­
U.
S.
Population:
0.000068
1.99
0.000422
12.42
0.002442
71.82
All
infants:
0.000179
5.26
0.000707
20.80
0.003239
95.25
Children
1­
2
yrs:
0.000387
11.38
0.001734
50.99
0.008249
242.61
Children
3­
5
yrs:
0.000270
7.94
0.001174
34.52
0.005862
172.41
Children
6­
12
yrs:
0.000133
3.92
0.000600
17.64
0.003064
90.13
Youth
13­
19
yrs:
0.000025
0.74
0.000272
8.01
0.001581
46.50
Adults
20­
49
yrs:
0.000038
1.11
0.000269
7.92
0.001797
52.87
Adults
50+
yrs:
0.000058
1.69
0.000296
8.69
0.001831
53.85
Females
13­
49
yrs:
0.000039
1.16
0.000288
8.47
0.001930
56.76
Triadimefon
Dietary
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Attachment
7.
Acute
Food
Only
Critical
Exposure
Contribution
Analysis.

U.
S.
Environmental
Protection
Agency
DEEM­
FCID
Acute
Critical
Exposure
Contribution
Analysis
(
Ver
2.02)
CSFII
1994­
98
Residue
file
=
C:\
Pesticides\
Triadimefon\
Dietary\
Acute\
Triadimefon
acute
(
food
only).
R98
Date
and
time
of
analysis:
11­
16­
2005
18:
03:
57
Daily
totals
for
food
and
foodform
consumption
used.
Adjustment
factor
#
2
used.
Minimum
exposure
contribution
=
1%
Monte
Carlo
Iterations
=
1000
Seed
=
1
CEC
records
generated
for
first
97
iterations.
Exposures
divided
by
body
weight
================================================================================
U.
S.
Population
Low
percentile
for
CEC
records:
99
Exposure
(
mg/
day)
=
0.000422
High
percentile
for
CEC
records:
100
Exposure
(
mg/
day)
=
0.057738
Number
of
actual
records
in
this
interval:
75173
Critical
foods/
foodforms
for
this
population
(
as
derived
from
these
records):
N=
number
of
appearances
in
all
records
(
including
duplicates)
%=
percent
of
total
exposure
for
all
records
(
including
duplicates)

Food
FF
N
Percent
Food
Name
­­­­­­­­
­­­
­­­­­
­­­­­­­
­­­­­­­­­­­­­
95002810
110
16953
15.51%
Pineapple,
juice­
Uncooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
95001760
110
4211
15.13%
Grape,
juice­
Uncooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
95001760
240
6980
11.24%
Grape,
juice­
Cooked;
Canned;
Cook
Meth
N/
S
13013200
240
12783
10.35%
Raspberry­
Cooked;
Canned;
Cook
Meth
N/
S
95001750
110
4725
7.71%
Grape­
Uncooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
95002810
240
17659
5.85%
Pineapple,
juice­
Cooked;
Canned;
Cook
Meth
N/
S
95001780
130
2278
5.62%
Grape,
raisin­
Uncooked;
Dried;
Cook
Meth
N/
S
95002790
240
10324
5.19%
Pineapple­
Cooked;
Canned;
Cook
Meth
N/
S
13013200
110
4304
4.15%
Raspberry­
Uncooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
13013210
110
1322
3.63%
Raspberry,
juice­
Uncooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
95001790
110
2359
3.32%
Grape,
wine
and
sherry­
Uncooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
13013200
120
1013
1.81%
Raspberry­
Uncooked;
Frozen;
Cook
Meth
N/
S
95001761
240
706
1.80%
Grape,
juice­
babyfood­
Cooked;
Canned;
Cook
Meth
N/
S
13013201
240
1601
0.97%
Raspberry­
babyfood­
Cooked;
Canned;
Cook
Meth
N/
S
95002810
120
1601
0.94%
Pineapple,
juice­
Uncooked;
Frozen;
Cook
Meth
N/
S
95002811
240
2871
0.94%
Pineapple,
juice­
babyfood­
Cooked;
Canned;
Cook
Meth
N/
S
95001780
230
1257
0.85%
Grape,
raisin­
Cooked;
Dried;
Cook
Meth
N/
S
95002790
110
1750
0.73%
Pineapple­
Uncooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
95001780
211
1100
0.72%
Grape,
raisin­
Cooked;
Fresh
or
N/
S;
Baked
95001760
120
194
0.72%
Grape,
juice­
Uncooked;
Frozen;
Cook
Meth
N/
S
13013200
211
1212
0.48%
Raspberry­
Cooked;
Fresh
or
N/
S;
Baked
13013210
120
380
0.46%
Raspberry,
juice­
Uncooked;
Frozen;
Cook
Meth
N/
S
13013211
240
525
0.30%
Raspberry,
juice­
babyfood­
Cooked;
Canned;
Cook
Meth
N/
S
95001780
210
343
0.29%
Grape,
raisin­
Cooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
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13013210
240
963
0.26%
Raspberry,
juice­
Cooked;
Canned;
Cook
Meth
N/
S
95001750
210
509
0.23%
Grape­
Cooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
95002791
240
1289
0.18%
Pineapple­
babyfood­
Cooked;
Canned;
Cook
Meth
N/
S
95001750
240
900
0.16%
Grape­
Cooked;
Canned;
Cook
Meth
N/
S
95001760
210
382
0.14%
Grape,
juice­
Cooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
95001780
232
51
0.07%
Grape,
raisin­
Cooked;
Dried;
Boiled
95002800
130
163
0.05%
Pineapple,
dried­
Uncooked;
Dried;
Cook
Meth
N/
S
95002790
211
215
0.04%
Pineapple­
Cooked;
Fresh
or
N/
S;
Baked
95002790
210
301
0.02%
Pineapple­
Cooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
95001790
210
46
0.01%
Grape,
wine
and
sherry­
Cooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
11000100
240
540
0.01%
Apple,
juice­
Cooked;
Canned;
Cook
Meth
N/
S
11000100
110
370
0.01%
Apple,
juice­
Uncooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
95001770
211
13
0.01%
Grape,
leaves­
Cooked;
Fresh
or
N/
S;
Baked
95001780
213
7
0.01%
Grape,
raisin­
Cooked;
Fresh
or
N/
S;
Fried
11000070
110
312
0.01%
Apple,
fruit
with
peel­
Uncooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
95001780
212
14
0.01%
Grape,
raisin­
Cooked;
Fresh
or
N/
S;
Boiled
11000110
212
121
0.00%
Apple,
sauce­
Cooked;
Fresh
or
N/
S;
Boiled
95001780
110
5
0.00%
Grape,
raisin­
Uncooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
11000111
240
113
0.00%
Apple,
sauce­
babyfood­
Cooked;
Canned;
Cook
Meth
N/
S
11000101
240
87
0.00%
Apple,
juice­
babyfood­
Cooked;
Canned;
Cook
Meth
N/
S
95001790
212
4
0.00%
Grape,
wine
and
sherry­
Cooked;
Fresh
or
N/
S;
Boiled
11002681
240
30
0.00%
Pear,
juice­
babyfood­
Cooked;
Canned;
Cook
Meth
N/
S
11002660
240
62
0.00%
Pear­
Cooked;
Canned;
Cook
Meth
N/
S
95001790
240
5
0.00%
Grape,
wine
and
sherry­
Cooked;
Canned;
Cook
Meth
N/
S
95002810
211
51
0.00%
Pineapple,
juice­
Cooked;
Fresh
or
N/
S;
Baked
11000081
240
70
0.00%
Apple,
peeled
fruit­
babyfood­
Cooked;
Canned;
Cook
Meth
N/
S
95001790
213
5
0.00%
Grape,
wine
and
sherry­
Cooked;
Fresh
or
N/
S;
Fried
11002660
110
25
0.00%
Pear­
Uncooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
95002790
212
37
0.00%
Pineapple­
Cooked;
Fresh
or
N/
S;
Boiled
95001770
210
2
0.00%
Grape,
leaves­
Cooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
11000100
120
5
0.00%
Apple,
juice­
Uncooked;
Frozen;
Cook
Meth
N/
S
95001790
221
3
0.00%
Grape,
wine
and
sherry­
Cooked;
Frozen;
Baked
11002661
240
22
0.00%
Pear­
babyfood­
Cooked;
Canned;
Cook
Meth
N/
S
95002810
212
37
0.00%
Pineapple,
juice­
Cooked;
Fresh
or
N/
S;
Boiled
95001780
240
5
0.00%
Grape,
raisin­
Cooked;
Canned;
Cook
Meth
N/
S
95001750
120
4
0.00%
Grape­
Uncooked;
Frozen;
Cook
Meth
N/
S
11002680
240
9
0.00%
Pear,
juice­
Cooked;
Canned;
Cook
Meth
N/
S
11002660
210
13
0.00%
Pear­
Cooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
11000110
210
2
0.00%
Apple,
sauce­
Cooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
11002670
130
3
0.00%
Pear,
dried­
Uncooked;
Dried;
Cook
Meth
N/
S
11000090
130
12
0.00%
Apple,
dried­
Uncooked;
Dried;
Cook
Meth
N/
S
11000080
211
3
0.00%
Apple,
peeled
fruit­
Cooked;
Fresh
or
N/
S;
Baked
11000070
211
3
0.00%
Apple,
fruit
with
peel­
Cooked;
Fresh
or
N/
S;
Baked
11002680
110
1
0.00%
Pear,
juice­
Uncooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
11000100
210
2
0.00%
Apple,
juice­
Cooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
11000090
211
2
0.00%
Apple,
dried­
Cooked;
Fresh
or
N/
S;
Baked
================================================================================
Children
1­
2
yrs
Low
percentile
for
CEC
records:
99
Exposure
(
mg/
day)
=
0.001734
High
percentile
for
CEC
records:
100
Exposure
(
mg/
day)
=
0.057738
Number
of
actual
records
in
this
interval:
4158
Critical
foods/
foodforms
for
this
population
(
as
derived
from
these
records):
N=
number
of
appearances
in
all
records
(
including
duplicates)
%=
percent
of
total
exposure
for
all
records
(
including
duplicates)
Triadimefon
Dietary
Exposure
Assessment
­
RED
DP
Barcode:
314778
Page
27
of
39
Food
FF
N
Percent
Food
Name
­­­­­­­­
­­­
­­­­­
­­­­­­­
­­­­­­­­­­­­­
95001760
110
817
32.02%
Grape,
juice­
Uncooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
95001760
240
719
15.33%
Grape,
juice­
Cooked;
Canned;
Cook
Meth
N/
S
95002810
110
990
12.10%
Pineapple,
juice­
Uncooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
95001780
130
390
11.33%
Grape,
raisin­
Uncooked;
Dried;
Cook
Meth
N/
S
95001750
110
500
9.45%
Grape­
Uncooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
13013210
110
140
5.08%
Raspberry,
juice­
Uncooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
13013200
240
322
3.23%
Raspberry­
Cooked;
Canned;
Cook
Meth
N/
S
95002810
240
1134
2.32%
Pineapple,
juice­
Cooked;
Canned;
Cook
Meth
N/
S
13013200
110
179
2.19%
Raspberry­
Uncooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
95001761
240
68
2.11%
Grape,
juice­
babyfood­
Cooked;
Canned;
Cook
Meth
N/
S
95002790
240
399
1.95%
Pineapple­
Cooked;
Canned;
Cook
Meth
N/
S
95001760
120
44
1.80%
Grape,
juice­
Uncooked;
Frozen;
Cook
Meth
N/
S
13013211
240
30
0.22%
Raspberry,
juice­
babyfood­
Cooked;
Canned;
Cook
Meth
N/
S
95001780
230
27
0.20%
Grape,
raisin­
Cooked;
Dried;
Cook
Meth
N/
S
95001780
210
27
0.19%
Grape,
raisin­
Cooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
95001780
211
25
0.17%
Grape,
raisin­
Cooked;
Fresh
or
N/
S;
Baked
95002811
240
43
0.08%
Pineapple,
juice­
babyfood­
Cooked;
Canned;
Cook
Meth
N/
S
95002790
110
53
0.06%
Pineapple­
Uncooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
95001750
240
22
0.05%
Grape­
Cooked;
Canned;
Cook
Meth
N/
S
13013200
211
26
0.02%
Raspberry­
Cooked;
Fresh
or
N/
S;
Baked
95001780
232
2
0.01%
Grape,
raisin­
Cooked;
Dried;
Boiled
95002810
120
8
0.01%
Pineapple,
juice­
Uncooked;
Frozen;
Cook
Meth
N/
S
13013201
240
7
0.01%
Raspberry­
babyfood­
Cooked;
Canned;
Cook
Meth
N/
S
95002790
211
9
0.01%
Pineapple­
Cooked;
Fresh
or
N/
S;
Baked
95001750
210
4
0.01%
Grape­
Cooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
95001760
210
6
0.01%
Grape,
juice­
Cooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
13013200
120
13
0.00%
Raspberry­
Uncooked;
Frozen;
Cook
Meth
N/
S
95002790
210
16
0.00%
Pineapple­
Cooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
11000100
110
6
0.00%
Apple,
juice­
Uncooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
11000100
120
2
0.00%
Apple,
juice­
Uncooked;
Frozen;
Cook
Meth
N/
S
95002800
130
2
0.00%
Pineapple,
dried­
Uncooked;
Dried;
Cook
Meth
N/
S
13013210
120
4
0.00%
Raspberry,
juice­
Uncooked;
Frozen;
Cook
Meth
N/
S
11002681
240
4
0.00%
Pear,
juice­
babyfood­
Cooked;
Canned;
Cook
Meth
N/
S
11000110
212
3
0.00%
Apple,
sauce­
Cooked;
Fresh
or
N/
S;
Boiled
11000101
240
2
0.00%
Apple,
juice­
babyfood­
Cooked;
Canned;
Cook
Meth
N/
S
13013210
240
3
0.00%
Raspberry,
juice­
Cooked;
Canned;
Cook
Meth
N/
S
11000100
240
3
0.00%
Apple,
juice­
Cooked;
Canned;
Cook
Meth
N/
S
11002660
110
2
0.00%
Pear­
Uncooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
11000070
110
2
0.00%
Apple,
fruit
with
peel­
Uncooked;
Fresh
or
N/
S;
Cook
Meth
N/
S
95002791
240
1
0.00%
Pineapple­
babyfood­
Cooked;
Canned;
Cook
Meth
N/
S
11002660
240
1
0.00%
Pear­
Cooked;
Canned;
Cook
Meth
N/
S
Triadimefon
Dietary
Exposure
Assessment
­
RED
DP
Barcode:
314778
Page
28
of
39
Attachment
8.
Acute
Water
Only
Results
File.

U.
S.
Environmental
Protection
Agency
Ver.
2.02
DEEM­
FCID
ACUTE
Analysis
for
TRIADIMEFON
(
1994­
98
data)
Residue
file:
Triadimefon
acute
(
water
only).
R98
Adjustment
factor
#
2
used.
Analysis
Date:
11­
14­
2005/
19:
21:
24
Residue
file
dated:
11­
14­
2005/
17:
52:
02/
8
Daily
totals
for
food
and
foodform
consumption
used.
MC
iterations
=
1000
MC
list
in
residue
file
MC
seed
=
1
Run
Comment:
"
Water
Only"
===============================================================================

Summary
calculations
(
per
capita):

95th
Percentile
99th
Percentile
99.9th
Percentile
Exposure
%
aRfD
Exposure
%
aRfD
Exposure
%
aRfD
­­­­­­­­­­
­­­­­­­­
­­­­­­­­­­
­­­­­­­­
­­­­­­­­­­
­­­­­­­­
U.
S.
Population:
0.006657
195.78
0.012883
378.90
0.028500
838.24
All
infants:
0.024712
726.82
0.043759
1287.04
0.080379
2364.10
Children
1­
2
yrs:
0.010362
304.77
0.019156
563.42
0.036609
1076.72
Children
3­
5
yrs:
0.009429
277.34
0.017136
504.01
0.033071
972.67
Children
6­
12
yrs:
0.006557
192.86
0.011995
352.80
0.022416
659.29
Youth
13­
19
yrs:
0.005139
151.16
0.009903
291.27
0.021279
625.85
Adults
20­
49
yrs:
0.006201
182.38
0.011468
337.31
0.023409
688.50
Adults
50+
yrs:
0.005984
176.01
0.010054
295.71
0.018441
542.39
Females
13­
49
yrs:
0.006262
184.18
0.011438
336.40
0.022996
676.35
Triadimefon
Dietary
Exposure
Assessment
­
RED
DP
Barcode:
314778
Page
29
of
39
Attachment
9.
Acute
Water
Only
(
3
Applications
Per
Year)
Results
File.

U.
S.
Environmental
Protection
Agency
Ver.
2.02
DEEM­
FCID
ACUTE
Analysis
for
TRIADIMEFON
(
1994­
98
data)
Residue
file:
Triadimefon
acute
(
3
applications
water
only).
R98
Adjustment
factor
#
2
used.
Analysis
Date:
11­
14­
2005/
19:
28:
20
Residue
file
dated:
11­
14­
2005/
17:
54:
12/
8
Daily
totals
for
food
and
foodform
consumption
used.
MC
iterations
=
1000
MC
list
in
residue
file
MC
seed
=
1
Run
Comment:
"
Water
Only"
===============================================================================

Summary
calculations
(
per
capita):

95th
Percentile
99th
Percentile
99.9th
Percentile
Exposure
%
aRfD
Exposure
%
aRfD
Exposure
%
aRfD
­­­­­­­­­­
­­­­­­­­
­­­­­­­­­­
­­­­­­­­
­­­­­­­­­­
­­­­­­­­
U.
S.
Population:
0.001153
33.91
0.002816
82.82
0.007339
215.85
All
infants:
0.004167
122.56
0.010143
298.33
0.024312
715.07
Children
1­
2
yrs:
0.001761
51.80
0.004320
127.05
0.010711
315.03
Children
3­
5
yrs:
0.001631
47.98
0.003923
115.38
0.009479
278.80
Children
6­
12
yrs:
0.001125
33.10
0.002722
80.05
0.006580
193.53
Youth
13­
19
yrs:
0.000854
25.11
0.002162
63.60
0.005535
162.81
Adults
20­
49
yrs:
0.001083
31.84
0.002591
76.20
0.006458
189.95
Adults
50+
yrs:
0.001118
32.88
0.002491
73.25
0.005694
167.48
Females
13­
49
yrs:
0.001085
31.90
0.002600
76.47
0.006428
189.05
Triadimefon
Dietary
Exposure
Assessment
­
RED
DP
Barcode:
314778
Page
30
of
39
Attachment
10.
Acute
Food
and
Surface
Water
(
3
Applications
Per
Year)
Results
File.

U.
S.
Environmental
Protection
Agency
Ver.
2.02
DEEM­
FCID
ACUTE
Analysis
for
TRIADIMEFON
(
1994­
98
data)
Residue
file:
Triadimefon
acute
(
3
applications).
R98
Adjustment
factor
#
2
used.
Analysis
Date:
11­
16­
2005/
18:
01:
42
Residue
file
dated:
11­
14­
2005/
17:
54:
59/
8
Daily
totals
for
food
and
foodform
consumption
used.
MC
iterations
=
1000
MC
list
in
residue
file
MC
seed
=
1
Run
Comment:
"
Food
and
Water"
===============================================================================

Summary
calculations
(
per
capita):

95th
Percentile
99th
Percentile
99.9th
Percentile
Exposure
%
aRfD
Exposure
%
aRfD
Exposure
%
aRfD
­­­­­­­­­­
­­­­­­­­
­­­­­­­­­­
­­­­­­­­
­­­­­­­­­­
­­­­­­­­
U.
S.
Population:
0.001222
35.94
0.002965
87.19
0.007654
225.13
All
infants:
0.004245
124.85
0.010248
301.43
0.024253
713.31
Children
1­
2
yrs:
0.002058
60.53
0.005060
148.81
0.012677
372.84
Children
3­
5
yrs:
0.001841
54.14
0.004419
129.97
0.010709
314.97
Children
6­
12
yrs:
0.001224
35.99
0.002935
86.33
0.006946
204.29
Youth
13­
19
yrs:
0.000891
26.21
0.002224
65.40
0.005649
166.15
Adults
20­
49
yrs:
0.001128
33.17
0.002685
78.96
0.006565
193.08
Adults
50+
yrs:
0.001168
34.35
0.002585
76.03
0.005836
171.66
Females
13­
49
yrs:
0.001134
33.37
0.002706
79.59
0.006548
192.60
Triadimefon
Dietary
Exposure
Assessment
­
RED
DP
Barcode:
314778
Page
31
of
39
Attachment
11.
Chronic
Food
and
Surface
Water
Residue
Input
File.

U.
S.
Environmental
Protection
Agency
Ver.
2.00
DEEM­
FCID
Chronic
analysis
for
TRIADIMEFON
1994­
98
data
Residue
file:
C:\
Pesticides\
Triadimefon\
Dietary\
Chronic\
Triadimefon
chronic.
R98
Adjust.
#
2
used
Analysis
Date
11­
16­
2005
Residue
file
dated:
11­
16­
2005/
17:
35:
08/
8
Reference
dose
(
RfD)
=
0.0034
mg/
kg
bw/
day
Comment:
Food
and
Water
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Food
Crop
Residue
Adj.
Factors
Comment
EPA
Code
Grp
Food
Name
(
ppm)
#
1
#
2
­­­­­­­­
­­­­
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­
­­­­­­
­­­­­­
­­­­­
­­
11000070
11
Apple,
fruit
with
peel
0.000100
1.000
1.000
11000080
11
Apple,
peeled
fruit
0.000100
1.000
1.000
11000081
11
Apple,
peeled
fruit­
babyfood
0.000100
1.000
1.000
11000090
11
Apple,
dried
0.000100
8.000
1.000
11000091
11
Apple,
dried­
babyfood
0.000100
8.000
1.000
11000100
11
Apple,
juice
0.000100
0.600
1.000
11000101
11
Apple,
juice­
babyfood
0.000100
0.600
1.000
11000110
11
Apple,
sauce
0.000100
1.000
1.000
11000111
11
Apple,
sauce­
babyfood
0.000100
1.000
1.000
95001750
O
Grape
0.002600
1.000
1.000
95001760
O
Grape,
juice
0.002600
1.000
1.000
95001761
O
Grape,
juice­
babyfood
0.002600
1.000
1.000
95001770
O
Grape,
leaves
0.002600
1.000
1.000
95001780
O
Grape,
raisin
0.002600
4.000
1.000
95001790
O
Grape,
wine
and
sherry
0.002600
1.000
1.000
11002660
11
Pear
0.000100
1.000
1.000
11002661
11
Pear­
babyfood
0.000100
1.000
1.000
11002670
11
Pear,
dried
0.000100
6.250
1.000
11002680
11
Pear,
juice
0.000100
1.000
1.000
11002681
11
Pear,
juice­
babyfood
0.000100
1.000
1.000
95002790
O
Pineapple
0.079000
1.000
1.000
95002791
O
Pineapple­
babyfood
0.079000
1.000
1.000
95002800
O
Pineapple,
dried
0.079000
5.000
1.000
95002810
O
Pineapple,
juice
0.079000
1.000
1.000
95002811
O
Pineapple,
juice­
babyfood
0.079000
1.000
1.000
13013200
13A
Raspberry
0.510000
1.000
1.000
13013201
13A
Raspberry­
babyfood
0.510000
1.000
1.000
13013210
13A
Raspberry,
juice
0.510000
1.000
1.000
13013211
13A
Raspberry,
juice­
babyfood
0.510000
1.000
1.000
86010000
O
Water,
direct,
all
sources
0.146700
1.000
1.000
86020000
O
Water,
indirect,
all
sources
0.146700
1.000
1.000
Triadimefon
Dietary
Exposure
Assessment
­
RED
DP
Barcode:
314778
Page
32
of
39
Attachment
12.
Chronic
Food
and
Surface
Water
Results
File.

U.
S.
Environmental
Protection
Agency
Ver.
2.00
DEEM­
FCID
Chronic
analysis
for
TRIADIMEFON
(
1994­
98
data)
Residue
file
name:
C:\
Pesticides\
Triadimefon\
Dietary\
Chronic\
Triadimefon
chronic.
R98
Adjustment
factor
#
2
used.
Analysis
Date
11­
16­
2005/
17:
37:
10
Residue
file
dated:
11­
16­
2005/
17:
35:
08/
8
Reference
dose
(
RfD,
Chronic)
=
.0034
mg/
kg
bw/
day
COMMENT
1:
Food
and
Water
===============================================================================
Total
exposure
by
population
subgroup
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­

Total
Exposure
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Population
mg/
kg
Percent
of
Subgroup
body
wt/
day
Rfd
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­­­­
­­­­­­­­­­­­­­­
U.
S.
Population
(
total)
0.003107
91.4%

U.
S.
Population
(
spring
season)
0.003079
90.6%
U.
S.
Population
(
summer
season)
0.003339
98.2%
U.
S.
Population
(
autumn
season)
0.003003
88.3%
U.
S.
Population
(
winter
season)
0.003004
88.4%

Northeast
region
0.002835
83.4%
Midwest
region
0.003141
92.4%
Southern
region
0.002951
86.8%
Western
region
0.003564
104.8%

Hispanics
0.003525
103.7%
Non­
hispanic
whites
0.003033
89.2%
Non­
hispanic
blacks
0.002947
86.7%
Non­
hisp/
non­
white/
non­
black
0.003804
111.9%

All
infants
(<
1
year)
0.010166
299.0%
Nursing
infants
0.003776
111.1%
Non­
nursing
infants
0.012591
370.3%
Children
1­
6
yrs
0.004369
128.5%
Children
7­
12
yrs
0.002832
83.3%

Females
13­
19
(
not
preg
or
nursing)
0.002183
64.2%
Females
20+
(
not
preg
or
nursing)
0.003098
91.1%
Females
13­
50
yrs
0.003003
88.3%
Females
13+
(
preg/
not
nursing)
0.003019
88.8%
Females
13+
(
nursing)
0.004306
126.6%

Males
13­
19
yrs
0.002286
67.2%
Triadimefon
Dietary
Exposure
Assessment
­
RED
DP
Barcode:
314778
Page
33
of
39
Males
20+
yrs
0.002780
81.8%
Seniors
55+
0.003046
89.6%

Children
1­
2
yrs
0.004655
136.9%
Children
3­
5
yrs
0.004345
127.8%
Children
6­
12
yrs
0.002990
87.9%
Youth
13­
19
yrs
0.002244
66.0%
Adults
20­
49
yrs
0.002897
85.2%
Adults
50+
yrs
0.003049
89.7%
Females
13­
49
yrs
0.002886
84.9%

Attachment
13.
Chronic
Food
and
Surface
Water
Critical
Exposure
Contribution
Analysis.

U.
S.
Environmental
Protection
Agency
Ver.
2.00
DEEM­
FCID
Chronic
analysis
for
TRIADIMEFON
(
1994­
98
data)
Residue
file
name:
C:\
Pesticides\
Triadimefon\
Dietary\
Chronic\
Triadimefon
chronic.
R98
Adjustment
factor
#
2
used.
Analysis
Date
11­
16­
2005/
17:
38:
47
Residue
file
dated:
11­
16­
2005/
17:
35:
08/
8
Reference
dose
(
RfD,
Chronic)
=
.0034
mg/
kg
bw/
day
COMMENT
1:
Food
and
Water
===============================================================================
Critical
Commodity
Contribution
Analysis
for
All
infants
(<
1
year)

Total
Exposure
=.
0101664
mg/
kg
bw/
day
Crop
groups
with
total
exposure
contribution
>
99%
Foods/
Foodforms
with
exposure
contribution
>
.1%
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­

Crop
group
­­­­­­­­­­
Exposure
Analysis­­­­­­­
Food
mg/
kg
%
of
Total
Percent
Foodform
body
wt/
day
Exposure
of
RfD
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­­
­­­­­­­­­­
­­­­­­­­­

Crop
Group
=
(
O)
Other
Water,
direct,
all
sources
(
86010000):
FoodForm
N/
S
0.0013507
13.29%
39.73%
Water,
indirect,
all
sources
(
86020000):
FoodForm
N/
S
0.0087867
86.43%
258.43%
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­­
­­­­­­­­­­
­­­­­­­­­
Total
for
crop
group
0.0101585
99.92%
298.78%

Total
for
crop
groups
listed
above:
0.0101585
99.92%
298.8%
Triadimefon
Dietary
Exposure
Assessment
­
RED
DP
Barcode:
314778
Page
34
of
39
Attachment
14.
Chronic
Food
Only
Results
File.

U.
S.
Environmental
Protection
Agency
Ver.
2.00
DEEM­
FCID
Chronic
analysis
for
TRIADIMEFON
(
1994­
98
data)
Residue
file
name:
C:\
Pesticides\
Triadimefon\
Dietary\
Chronic\
Triadimefon
chronic
(
food
only).
R98
Adjustment
factor
#
2
used.
Analysis
Date
11­
16­
2005/
17:
39:
58
Residue
file
dated:
11­
16­
2005/
17:
35:
59/
8
Reference
dose
(
RfD,
Chronic)
=
.0034
mg/
kg
bw/
day
COMMENT
1:
Food
Only
===============================================================================
Total
exposure
by
population
subgroup
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­

Total
Exposure
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Population
mg/
kg
Percent
of
Subgroup
body
wt/
day
Rfd
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­­­­
­­­­­­­­­­­­­­­
U.
S.
Population
(
total)
0.000015
0.4%

U.
S.
Population
(
spring
season)
0.000014
0.4%
U.
S.
Population
(
summer
season)
0.000017
0.5%
U.
S.
Population
(
autumn
season)
0.000014
0.4%
U.
S.
Population
(
winter
season)
0.000015
0.4%

Northeast
region
0.000015
0.4%
Midwest
region
0.000015
0.4%
Southern
region
0.000012
0.4%
Western
region
0.000021
0.6%

Hispanics
0.000015
0.5%
Non­
hispanic
whites
0.000016
0.5%
Non­
hispanic
blacks
0.000012
0.4%
Non­
hisp/
non­
white/
non­
black
0.000013
0.4%

All
infants
(<
1
year)
0.000029
0.9%
Nursing
infants
0.000016
0.5%
Non­
nursing
infants
0.000034
1.0%
Children
1­
6
yrs
0.000050
1.5%
Children
7­
12
yrs
0.000023
0.7%

Females
13­
19
(
not
preg
or
nursing)
0.000007
0.2%
Females
20+
(
not
preg
or
nursing)
0.000011
0.3%
Females
13­
50
yrs
0.000012
0.3%
Females
13+
(
preg/
not
nursing)
0.000012
0.4%
Females
13+
(
nursing)
0.000022
0.6%
Triadimefon
Dietary
Exposure
Assessment
­
RED
DP
Barcode:
314778
Page
35
of
39
Males
13­
19
yrs
0.000011
0.3%
Males
20+
yrs
0.000009
0.3%
Seniors
55+
0.000010
0.3%

Children
1­
2
yrs
0.000063
1.8%
Children
3­
5
yrs
0.000047
1.4%
Children
6­
12
yrs
0.000025
0.7%
Youth
13­
19
yrs
0.000009
0.3%
Adults
20­
49
yrs
0.000010
0.3%
Adults
50+
yrs
0.000011
0.3%
Females
13­
49
yrs
0.000011
0.3%

Attachment
15.
Chronic
Water
Only
Results
File.

U.
S.
Environmental
Protection
Agency
Ver.
2.00
DEEM­
FCID
Chronic
analysis
for
TRIADIMEFON
(
1994­
98
data)
Residue
file
name:
C:\
Pesticides\
Triadimefon\
Dietary\
Chronic\
Triadimefon
chronic
(
water
only).
R98
Adjustment
factor
#
2
used.
Analysis
Date
11­
15­
2005/
11:
45:
42
Residue
file
dated:
09­
12­
2005/
20:
20:
40/
8
Reference
dose
(
RfD,
Chronic)
=
0.0034
mg/
kg
bw/
day
COMMENT
1:
Water
Only
===============================================================================
Total
exposure
by
population
subgroup
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­

Total
Exposure
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Population
mg/
kg
Percent
of
Subgroup
body
wt/
day
Rfd
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­­­­
­­­­­­­­­­­­­­­
U.
S.
Population
(
total)
0.003092
90.9%

U.
S.
Population
(
spring
season)
0.003065
90.1%
U.
S.
Population
(
summer
season)
0.003321
97.7%
U.
S.
Population
(
autumn
season)
0.002989
87.9%
U.
S.
Population
(
winter
season)
0.002989
87.9%

Northeast
region
0.002821
83.0%
Midwest
region
0.003126
91.9%
Southern
region
0.002939
86.4%
Western
region
0.003543
104.2%

Hispanics
0.003510
103.2%
Non­
hispanic
whites
0.003017
88.7%
Non­
hispanic
blacks
0.002935
86.3%
Non­
hisp/
non­
white/
non­
black
0.003791
111.5%

All
infants
(<
1
year)
0.010137
298.2%
Nursing
infants
0.003760
110.6%
Non­
nursing
infants
0.012557
369.3%
Children
1­
6
yrs
0.004320
127.1%
Children
7­
12
yrs
0.002809
82.6%

Females
13­
19
(
not
preg
or
nursing)
0.002176
64.0%
Females
20+
(
not
preg
or
nursing)
0.003086
90.8%
Females
13­
50
yrs
0.002991
88.0%
Females
13+
(
preg/
not
nursing)
0.003007
88.4%
Triadimefon
Dietary
Exposure
Assessment
­
RED
DP
Barcode:
314778
Page
36
of
39
Females
13+
(
nursing)
0.004284
126.0%

Males
13­
19
yrs
0.002275
66.9%
Males
20+
yrs
0.002771
81.5%
Seniors
55+
0.003036
89.3%

Children
1­
2
yrs
0.004592
135.0%
Children
3­
5
yrs
0.004299
126.4%
Children
6­
12
yrs
0.002965
87.2%
Youth
13­
19
yrs
0.002235
65.7%
Adults
20­
49
yrs
0.002887
84.9%
Adults
50+
yrs
0.003037
89.3%
Females
13­
49
yrs
0.002875
84.6%

Attachment
16.
Chronic
Food
and
Surface
Water
(
3
Applications
Per
Year)
Results
File.

U.
S.
Environmental
Protection
Agency
Ver.
2.00
DEEM­
FCID
Chronic
analysis
for
TRIADIMEFON
(
1994­
98
data)
Residue
file
name:
C:\
Pesticides\
Triadimefon\
Dietary\
Chronic\
Triadimefon
chronic
(
3
applications).
R98
Adjustment
factor
#
2
used.
Analysis
Date
11­
16­
2005/
17:
39:
31
Residue
file
dated:
11­
16­
2005/
17:
36:
41/
8
Reference
dose
(
RfD,
Chronic)
=
.0034
mg/
kg
bw/
day
COMMENT
1:
Food
and
Water
===============================================================================
Total
exposure
by
population
subgroup
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­

Total
Exposure
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Population
mg/
kg
Percent
of
Subgroup
body
wt/
day
Rfd
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­­­­
­­­­­­­­­­­­­­­
U.
S.
Population
(
total)
0.000542
15.9%

U.
S.
Population
(
spring
season)
0.000536
15.8%
U.
S.
Population
(
summer
season)
0.000583
17.1%
U.
S.
Population
(
autumn
season)
0.000523
15.4%
U.
S.
Population
(
winter
season)
0.000524
15.4%

Northeast
region
0.000495
14.6%
Midwest
region
0.000548
16.1%
Southern
region
0.000512
15.1%
Western
region
0.000624
18.4%

Hispanics
0.000613
18.0%
Non­
hispanic
whites
0.000530
15.6%
Non­
hispanic
blacks
0.000512
15.1%
Non­
hisp/
non­
white/
non­
black
0.000659
19.4%

All
infants
(<
1
year)
0.001755
51.6%
Nursing
infants
0.000656
19.3%
Non­
nursing
infants
0.002172
63.9%
Children
1­
6
yrs
0.000785
23.1%
Children
7­
12
yrs
0.000502
14.8%

Females
13­
19
(
not
preg
or
nursing)
0.000378
11.1%
Females
20+
(
not
preg
or
nursing)
0.000537
15.8%
Females
13­
50
yrs
0.000521
15.3%
Females
13+
(
preg/
not
nursing)
0.000524
15.4%
Triadimefon
Dietary
Exposure
Assessment
­
RED
DP
Barcode:
314778
Page
37
of
39
Females
13+
(
nursing)
0.000751
22.1%

Males
13­
19
yrs
0.000399
11.7%
Males
20+
yrs
0.000481
14.1%
Seniors
55+
0.000527
15.5%

Children
1­
2
yrs
0.000845
24.8%
Children
3­
5
yrs
0.000779
22.9%
Children
6­
12
yrs
0.000529
15.6%
Youth
13­
19
yrs
0.000390
11.5%
Adults
20­
49
yrs
0.000501
14.7%
Adults
50+
yrs
0.000529
15.5%
Females
13­
49
yrs
0.000500
14.7%

Attachment
17.
Usage
Report
in
Support
of
Reregistration
for
Triadimefon.

Triadimefon
(
109901)
Screening
Level
Usage
Analysis
(
SLUA)
Date:
6/
2/
05
What
is
a
Screening
Level
Usage
Analysis
(
SLUA)?
°
Available
estimates
of
pesticide
usage
data
for
a
particular
active
ingredient
that
is
used
on
agricultural
crops
in
the
United
States.

What
does
it
contain?
°
Pesticide
usage
data
for
a
single
active
ingredient
only.
°
Agricultural
use
sites
(
crops)
that
the
pesticide
is
reported
to
be
used
on.
°
Available
pesticide
usage
information
(
i.
e.,
does
not
include
all
of
the
United
States).
°
Annual
percent
of
crop
treated
(
average
&
maximum)
for
each
agricultural
crop.
°
Average
annual
pounds
of
the
pesticide
applied
for
each
agricultural
crop
(
i.
e.,
for
the
states
surveyed,
not
for
the
entire
United
States).

What
assumptions
can
I
make
about
the
reported
data?
°
Average
pounds
of
active
ingredient
applied
­
Values
are
calculated
by
merging
pesticide
usage
data
sources
together;
averaging
by
year,
averaging
across
all
years,
&
then
rounding.
Note:
If
the
estimated
value
is
less
than
500,
then
that
value
is
labeled
<
500.
Estimated
values
between
500
&
<
1,000,000
are
rounded
to
1
significant
digit.
Estimated
values
of
1,000,000
or
greater
are
rounded
to
2
significant
digits.)
°
Average
percent
of
crop
treated
­
Values
are
calculated
by
merging
data
sources
together;
averaging
by
year,
averaging
across
all
years,
&
rounding
to
the
nearest
multiple
of
5.
Note:
If
the
estimated
value
is
less
than
1,
then
the
value
is
labeled
<
1.
°
Maximum
percent
of
crop
treated
­
Value
is
the
single
maximum
value
reported
Triadimefon
Dietary
Exposure
Assessment
­
RED
DP
Barcode:
314778
Page
38
of
39
across
all
data
sources,
across
all
years,
&
rounded
up
to
the
nearest
multiple
of
5.
Note:
If
the
estimated
value
is
less
than
2.5,
then
the
value
is
labeled
<
2.5.

What
are
the
data
sources
used?
°
USDA­
NASS
(
United
States
Department
of
Agriculture's
National
Agricultural
Statistics
Service)
 
pesticide
usage
data
from
1998
to
2003.
°
NCFAP
(
National
Center
for
Food
and
Agricultural
Policy)
 
pesticide
usage
data
from
1997
&
is
only
used
if
data
is
not
available
from
the
other
sources.
°
Private
pesticide
market
research
 
pesticide
usage
data
from
1998
to
2003.
°
California
DPR
data
can
be
requested
separately.

What
are
the
limitations
to
the
data?
°
Additional
registered
uses
may
exist
but
are
not
included
because
the
available
surveys
do
not
report
usage
(
e.
g.,
small
acreage
crops).
°
Lack
of
reported
usage
data
for
the
pesticide
on
a
crop
does
not
imply
zero
usage.
°
Usage
data
on
a
particular
site
may
be
noted
in
data
sources,
but
not
quantified.
°
In
these
instances,
the
site
would
not
be
reported
in
the
SLUA.
°
Non­
agricultural
use
sites
(
e.
g.,
turf,
post­
harvest,
mosquito
control,
etc.)
are
not
reported
in
the
SLUA.
A
separate
request
must
be
made
to
receive
these
estimates.

Who
do
I
contact
for
further
information
and/
or
questions
on
this
SLUA?
°
(
Jenna
Carter,
Botanist,
BEAD)/(
John
O'Neill,
Analyst,
BEAD)
°
((
703)
308­
8370,
carter.
jenna@
epa.
gov)/
((
703)
308­
8118,
Oneill.
John
@
epa.
gov)

Tuesday,
May
31,
2005
13:
46
Screening
Level
Estimates
of
Agricultural
Uses
of
Triadimefon
(
109901)
Sorted
Alphabetically
Crop
Lbs.
A.
I.
Percent
Crop
Treated
Avg.
Max.
1
Almonds
<
500
<
1
<
2.5
2
Apples
4,000
5
10
3
Artichokes
(
NCFAP
'
97)
<
500
30
4
Asparagus
(
NCFAP
'
97)
<
500
15
5
Cabbage
(
NCFAP
'
97)
<
500
10
6
Cantaloupes
<
500
<
1
10
7
Cherries
<
500
<
1
<
2.5
8
Cucumbers
<
500
<
1
<
2.5
9
Grapes
1,000
<
1
5
10
Honeydew
<
500
5
5
11
Pears
1,000
5
5
12
Pumpkins
1,000
5
15
13
Raspberries
(
NCFAP
'
97)
<
500
50
14
Squash
<
500
<
1
5
15
Sugar
Beets
<
500
<
1
<
2.5
Triadimefon
Dietary
Exposure
Assessment
­
RED
DP
Barcode:
314778
Page
39
of
39
16
Watermelons
<
500
<
1
5
17
Wheat
1,000
<
1
<
2.5
______________________________________

All
numbers
rounded.
'<
500'
indicates
less
than
500
pounds
of
active
ingredient.
'<
2.5'
indicates
less
than
2.5
percent
of
crop
is
treated.
