
1
of
4
UNITED
STATES
ENVIRONMENTAL
PROTECTION
AGENCY
WASHINGTON,
D.
C.
20460
OFFICE
OF
PREVENTION,
PESTICIDES,
AND
TOXIC
SUBSTANCES
March
1,
2006
MEMORANDUM
SUBJECT:
Transmittal
of
Revised
Meeting
Minutes
of
the
FIFRA
Scientific
Advisory
Panel
Meeting
Held
December
6­
8,
2005
on
Plant­
Incorporated
Protectants
Based
on
Virus
Coat
Protein
Genes:
Science
Issues
Associated
with
the
Proposed
Rule
TO:
Clifford
J.
Gabriel,
Ph.
D.
Director
Office
of
Science
Coordination
and
Policy
FROM:
Paul
I.
Lewis,
Ph.
D.
Designated
Federal
Official
FIFRA
Scientific
Advisory
Panel
Office
of
Science
Coordination
and
Policy
Joseph
E.
Bailey
Designated
Federal
Official
FIFRA
Scientific
Advisory
Panel
Office
of
Science
Coordination
and
Policy
Attached,
please
find
revised
meeting
minutes
of
the
FIFRA
Scientific
Advisory
Panel
open
meeting
held
in
Arlington,
Virginia
on
December
6­
8,
2005.
This
report
addresses
a
set
of
scientific
issues
being
considered
by
the
Environmental
Protection
Agency
pertaining
to
Plant­
Incorporated
Protectants
Based
on
Virus
Coat
Protein
Genes:
Science
Issues
Associated
with
the
Proposed
Rule.

Subsequent
to
issuance
of
the
final
minutes,
one
of
the
Panelists
from
this
meeting,
Dr.
Shou­
Wei
Ding,
noted
an
error
and
provided
a
clarification.
The
minutes
have
been
revised
as
follows:

Page
12,
sentence
reading:

If
designed
for
post­
translational
gene
silencing
(
PTGS),
this
restriction
need
not
apply.

has
been
changed
to:

If
designed
for
post­
transcriptional
gene
silencing
(
PTGS),
this
restriction
need
not
apply.
2
of
4
Page
13,
section
title
reading:

Post­
Translational
Gene
Silencing
has
been
changed
to:

Post­
Transcriptional
Gene
Silencing
Sentence
reading:

Post­
translational
gene
silencing
(
PTGS)
is
a
highly
desirable
transgenic
resistance
strategy
for
virus
resistance
because
1)
it
is
based
on
a
natural
plant
defense
mechanism
against
viruses
themselves,
2)
transgenes
can
easily
be
designed
to
produce
only
RNA,
not
protein,
and
3)
PTGS
gives
stronger
resistance
than
protein
methods.

has
been
changed
to:

PTGS
is
a
highly
desirable
transgenic
resistance
strategy
for
virus
resistance
because
1)
it
is
based
on
a
natural
plant
defense
mechanism
against
viruses
themselves,
2)
transgenes
can
easily
be
designed
to
produce
only
RNA,
not
protein,
and
3)
PTGS
gives
stronger
resistance
than
protein
methods.

Sentence
reading:

Two
types
of
PTGS­
inducing
transgenes
can
be
shown
to
express
no
protein:
1)
transgene
insertions,
and
2)
insertions
of
transcribed
inverted
repeat
(
IR)
constructs.

has
been
changed
to:

Two
types
of
PTGS­
inducing
transgenes
can
be
shown
to
express
no
protein:
1)
transgene
insertions
that
cannot
be
translated
into
proteins,
and
2)
insertions
of
transcribed
inverted
repeat
(
IR)
constructs.

Page
26,
sentence
reading:

If
the
sequence
was
designed
for
post­
translational
gene
silencing
(
PTGS),
this
restriction
does
not
apply.

has
been
changed
to:

If
the
sequence
was
designed
for
PTGS,
this
restriction
does
not
apply.

Attachment
3
of
4
cc:

Susan
Hazen
Margaret
Schneider
Amy
Farrell
Jim
Jones
Anne
Lindsay
Margie
Fehrenbach
Janet
Andersen
Debbie
Edwards
Steven
Bradbury
William
Diamond
Arnold
Layne
Tina
Levine
Lois
Rossi
Frank
Sanders
Randolph
Perfetti
William
Jordan
Douglas
Parsons
Enesta
Jones
Vanessa
Vu
(
SAB)
Tom
McClintock
Elizabeth
Milewski
Anne
Fairbrother
Melissa
Kramer
Rebecca
Edlestein
Tessa
Milofsky
OPP
Docket
FIFRA
Scientific
Advisory
Panel
Members
Stephen
M.
Roberts,
Ph.
D.
(
Chair
of
the
FIFRA
SAP)
John
Bucher,
Ph.
D.
Janice
E.
Chambers,
Ph.
D.
H.
Christopher
Frey,
Ph.
D.
Stuart
Handwerger,
M.
D.
Steven
G.
Heeringa,
Ph.
D.
Gary
Isom,
Ph.
D.
Kenneth
M.
Portier,
Ph.
D.

FQPA
Science
Review
Board
Members
Judith
Bender,
Ph.
D.
Judith
Brown,
Ph.
D.
George
Cobb,
Ph.
D.
Shou
Wei
Ding,
Ph.
D.
Bryce
W.
Falk,
Ph.
D.
Steven
Gendel,
Ph.
D.
Jonathan
Gressel,
Ph.
D.
Simon
P.
Hogan,
Ph.
D.
4
of
4
Roger
Hull,
Ph.
D.,
D.
Sc.

Alexander
Karasev,
Ph.
D.
Steven
A.
Lommel,
Ph.
D.
Diana
Pilson,
Ph.
D.
Lars
K.
Poulsen,
Ph.
D.,
M.
D.
Geoffrey
I.
Scott,
Ph.
D.
