Page
1
of
13
UNITED
STATES
ENVIRONMENTAL
PROTECTION
AGENCY
WASHINGTON,
D.
C.
20460
OFFICE
OF
PREVENTION,
PESTICIDES
AND
TOXIC
SUBSTANCES
August
29,
2005
MEMORANDUM:

SUBJECT:
Dicofol.
Refined
Post­
Application
Exposure
Estimates
(
Apples/
Pears,
Beans,
Cotton,
Cucurbits,
Grapes,
Sod/
Turf
Revised).

FROM:
Robert
Travaglini,
Chemist
Reregistration
Branch
3
Health
Effects
Division
(
7509C)

THRU:
Steven
Weiss,
Senior
Scientist
Reregistration
Branch
3
Health
Effects
Division
(
7509C)

TO:
Mika
Hunter,
Chemical
Review
Manager
Reregistration
Branch
3
Special
Review
and
Reregistration
Division
(
7508C)

DP
Barcode:
D
321186
PC
Code:
010501
This
memorandum
addresses
the
error­
correction
response
dated
August
17,
2005
from
Dow
Agrosciences
pertaining
to
the
HED
document
of
February
2,
2005
(
D
312593)
which
concerned
post­
application
exposures
and
risk
estimates
for
the
insecticide/
miticide
dicofol
on
apples/
pears,
beans,
cotton,
cucurbits,
grapes,
sod/
turf
farms
and
tomatoes/
peppers.
A
memorandum
which
addresses
the
Dow
Agrosciences
comments
is
attached.

This
document
reflects
current
HED
policy.
This
memorandum
addresses
post­
application
exposures
and
risk
estimates
for
the
insecticide/
miticide
dicofol,
in
continuation
of
the
reregistration
(
RED)
process
for
this
pesticide.
Attachments
for
this
document
are
the
appendices
for
the
short
and
intermediate­
term
postapplication
re­
entry
interval
(
REI)
calculations,
which
include
data
inputs
and
tables.

Background
In
recent
previous
registration
documents
concerning
occupational
exposure
dated
July
29,
2004
(
D305650)
and
December
9,
2004
(
D305651),
HED
re­
assessed
Re­
Entry
Interval
(
REIs)
for
the
following
crops
and/
or
crop
groups:
citrus,
stone
fruit
and
tree
nut
including
pecans
based
on
Special
Review
and
Reregistration
Division
(
SRRD)
request.

Subsequently,
SRRD
on
January
26,
2005
requested
HED
to
evaluate
post­
application
REIs
for
the
remaining
crops
listed
on
the
dicofol
label
which
were
not
re­
evaluated
in
the
preceding
refined
post­
application
assessments
at
the
maximum
label
application
rate
and
at
½
the
maximum
label
application
rate.
These
crops
and/
or
crop
groups
are:
apples/
pears;
beans;
dry
&
string;
beans;
cotton;
cucurbrits
(
cucumbers,
eegplants,
watermelons
etc);
grapes;
"
nonresidential
lawns
&
ornamentals;
and
tomatoes/
peppers.
HED
conducted
REI
calculations
for
the
requested
crops
and
the
results
are
presented
in
this
memorandum.

Note
that
where
HED
possessed
chemical
specific
dislodgeable
foliar
residue
(
DFR)
data
for
the
various
crops,
as
in
the
case
of
cotton
and
cucurbits,
this
data
was
used.
However,
in
the
remaining
crops,
HED
relied
on
default
REI
calculations
(
apples,
beans,
grapes,
turf
&
tomatoes/
peppers).
Additionally,
please
note
that
HED
does
not
assess
post­
application
exposures
for
"
non­
residential"
lawns
or
ornamentals
but
did
conduct
post­
application
exposures
from
dicofol
use
on
sod
farms.

In
November,
1999
HED
issued
a
revised
Occupational
Exposure
Assessment
for
the
miticide
dicofol
(
D260940).
A
short­
term
NOAEL
of
75
mg/
kg/
day
and
intermediate­
term
NOAEL
of
3
mg/
kg/
day
were
used
as
the
endpoints
in
the
assessment.
Since
these
endpoints
were
taken
from
dermal
studies,
a
dermal
absorption
factor
of
100%
was
utilized.
The
submitted
DFR
studies
were
deemed
in
compliance
with
Agency
guidelines,
scientifically
valid
and
were
utilized
in
assessing
post­
application
exposures.
The
target
MOE
for
dermal
exposures
is
100.

The
short
and
intermediate­
term
MOE
estimates
are
listed
by
crop
and/
or
crop
group
and
include
the
data
inputs
(
i.
e.
transfer
coefficients,
application
rates
etc.).
Note
that
crop
groupings
and
transfer
coefficients
are
from
the
Science
Advisory
Council
for
Exposure:
Policy
Memo
#
003.1
'
Agricultural
Transfer
Coefficients',
August
17,
2000.

Additionally,
these
estimates
employed
an
adult
body
weight
of
70
kg
and
standard
DFR
defaults
of:
Initial
Percent
of
Application
Rate
as
DFR
(%)
=
20;
Dissipation
Rate
per
day
(%)
=
10;
Initial
Percent
of
Rate
as
TTR
(%)
=
5.
Page
3
of
13
Post­
Application
Exposure
&
Risk
Estimates
for
Dicofol
by
Crop
Cotton
(
MRID
446856­
03
D
260098)

Summary
of
'
Days
After
Treatment'
to
Reach
the
Target
MOE
for
Short­
term
Exposure
Crop
Grouping
dicofol
­
cotton
Specific
Crops
Max
Foliar
Rate
(
lb
ai/
acre)
Days
After
Treatment
Target
MOE
Achieved
(
Target
MOE
=
100)

Exposure
Activity
Levels
Very
Low
Low
Medium
High
Very
High
Field
/
row
crops,
low
/

medium
Cotton
0.75
­
1.5
N/
A
0
0
0
­
2
N/
A
Summary
of
'
Days
After
Treatment'
to
Reach
the
Target
MOE
for
Intermediate­
term
Exposure
Field
/
row
crops,
low
/

medium
Cotton
0.75
­
1.5
N/
A
0
­
2
11
­
14
14
­
17
N/
A
Exposure
Inputs
Summary
Exposure
Potential
Transfer
Coefficients
(
cm2/
hr)
Activities
Used
for
RA
Range
Very
Low
N/
A
N/
A
N/
A
Low
100
TBD
Irrigation,
Scouting,
Weeding
(
hand),
Thinning
Medium
1500
486
­
2,760
Irrigation,
Scouting,
Weeding
(
hand)

High
2500
486
­
2,760
Harvest
(
hand)

Very
High
N/
A
N/
A
N/
A
Chemical:
dicofol
­
cotton
Date:
2­
2­
05
Page
4
of
13
Assessor:
RT
Transfer
Coefficient
Group:
Field
/
row
crops,
low
/
medium
Specific
Crop
Considered:
Cotton
Application
Rate
of
Crop
(
lb
ai/
A):
0.75
&
1.5
DFR
Data
Summary
Source:
CA
­
cotton
Slope
of
Semilog
Regression:
­
0.21615
Day
0
Concentration
(
ug/
cm):
3.5709
Study
Application
Rate
(
lb
ai/
A):
1.5
Limit
of
Quantification
(
ug/
cm2):
0.005
Cucurbits
(
MRID
446856­
02,
D
260196)

Summary
of
'
Days
After
Treatment'
to
Reach
the
Target
MOE
for
Short­
term
Exposure
Crop
Grouping
dicofol
­
cucumbers
Specific
Crops
Max
Foliar
Rate
(
lb
ai/
acre)
Days
After
Treatment
Target
MOE
Achieved
(
Target
MOE
=
100)

Exposure
Activity
Levels
Very
Low
Low
Medium
High
Very
High
Vegetable,
cucurbit
Cucurbits
0.315
­
0.63
N/
A
0
0
0
N/
A
Summary
of
'
Days
After
Treatment'
to
Reach
the
Target
MOE
for
Intermediate­
term
Exposure
Vegetable,
cucurbit
Cucurbits
0.315
­
0.63
N/
A
2
­
8
11
­
16
15
­
21
N/
A
Exposure
Potential
Transfer
Coefficients
(
cm2/
hr)
Activities
Used
for
RA
Range
Very
Low
N/
A
N/
A
N/
A
Low
500
486
­
2,760
Irrigation,
Scouting,
Thinning,
Weeding
(
hand)
Exposure
Potential
Transfer
Coefficients
(
cm2/
hr)
Activities
Used
for
RA
Range
Page
5
of
13
Medium
1500
486
­
2,760
Irrigation,
Scouting,
Weeding
(
hand)

High
2500
486
­
2,760
Harvest
(
hand),
Leaf
Pulling,
Pruning
(
hand),

Thinning,
Turning
Very
High
N/
A
N/
A
N/
A
Exposure
Inputs
Summary
Chemical:
dicofol
­
cucumbers
Date:
2­
2­
05
Assessor:
travagl
Transfer
Coefficient
Group:
Vegetable,
cucurbit
Specific
Crop
Considered:
Cucurbits
Application
Rate
of
Crop
(
lb
ai/
A):
0.63
&
0.315
DFR
Data
Summary
Source:

Slope
of
Semilog
Regression:
­
0.12553
Day
0
Concentration
(
ug/
cm):
1.293
Study
Application
Rate
(
lb
ai/
A):
0.625
Limit
of
Quantification
(
ug/
cm2):
0.005
Apples/
Pears
Summary
of
'
Days
After
Treatment'
to
Reach
the
Target
MOE
for
Short­
term
Exposure
Crop
Grouping
dicofol
­
apples
Specific
Crops
Max
Foliar
Rate
(
lb
ai/
acre)
Days
After
Treatment
Target
MOE
Achieved
(
Target
MOE
=
100)

Exposure
Activity
Levels
Very
Low
Low
Medium
High
Very
High
Trees,
fruit,
deciduous
Apples,
Pears
1.5
­
3
0
0
­
1
N/
A
0
­
5
5
­
11
Crop
Grouping
dicofol
­
apples
Specific
Crops
Max
Foliar
Rate
(
lb
ai/
acre)
Days
After
Treatment
Target
MOE
Achieved
(
Target
MOE
=
100)

Exposure
Activity
Levels
Very
Low
Low
Medium
High
Very
High
Page
6
of
13
Summary
of
'
Days
After
Treatment'
to
Reach
the
Target
MOE
for
Intermediate­
term
Exposure
Trees,
fruit,
deciduous
Apples,
Pears
1.5
­
3
3
­
9
25
­
31
N/
A
29
­
35
35
­
42
Exposure
Potential
Transfer
Coefficients
(
cm2/
hr)

(
1)
Activities
(
1)

Used
for
RA
Range
Very
Low
100
TBD
Propping
Low
1000
197
­
2,302
Scouting,
Weeding
(
hand),
Irrigation
Medium
N/
A
N/
A
N/
A
High
1500
1,421
­
4,393
Harvest
(
hand),
Propping,
Pruning
(
hand),

Training,
Tying
Very
High
3000
2,177
­
3,688
Thinning
Exposure
Inputs
Summary
Date:
2­
2­
05
Assessor:
RT
Transfer
Coefficient
Group:
Trees,
fruit,
deciduous
Specific
Crop
Considered:
Apples
Application
Rate
of
Crop
(
lb
ai/
A):
1.5
&
3.0
DFR
Data
Summary
No
study
data
was
used
for
this
crop's
assessment.
Page
7
of
13
Beans
Summary
of
'
Days
After
Treatment'
to
Reach
the
Target
MOE
for
Short­
term
Exposure
Crop
Grouping
(
1)
dicofol
­
beans
Specific
Crops
(
2)
Max
Foliar
Rate
(
lb
ai/
acre)
(
2)
Days
After
Treatment
Target
MOE
Achieved
(
Target
MOE
=
100)

Exposure
Activity
Levels
(
3,4)

Very
Low
Low
Medium
High
Very
High
Field
/
row
crops,
low
/

medium
Beans
(
dry),
Beans
(
string)
0.75
­
1.5
N/
A
0
0
0
­
3
N/
A
Summary
of
'
Days
After
Treatment'
to
Reach
the
Target
MOE
for
Intermediate­
term
Exposure
Field
/
row
crops,
low
/

medium
Beans
(
dry),
Beans
(
string)
0.75
­
1.5
N/
A
0
­
3
22
­
29
27
­
33
N/
A
Exposure
Potential
Transfer
Coefficients
(
cm2/
hr)
(
1)
Activities
(
1)

Used
for
RA
Range
Very
Low
N/
A
N/
A
N/
A
Low
100
TBD
Irrigation,
Scouting,
Weeding
(
hand),
Thinning
Medium
1500
486
­
2,760
Irrigation,
Scouting,
Weeding
(
hand)

High
2500
486
­
2,760
Harvest
(
hand)

Very
High
N/
A
N/
A
N/
A
Exposure
Inputs
Summary
Chemical:
dicofol
­
beans
Date:
2­
2­
05
Assessor:
RT
Page
8
of
13
Transfer
Coefficient
Group:
Field
/
row
crops,
low
/
medium
Specific
Crop
Considered:
Beans
(
dry)

Application
Rate
of
Crop
(
lb
ai/
A):
0.75
&
1.5
DFR
Data
Summary
No
study
data
was
used
for
this
crop's
assessment.

Grapes
Summary
of
'
Days
After
Treatment'
to
Reach
the
Target
MOE
for
Short­
term
Exposure
Crop
Grouping
(
1)
dicofol
­
grapes
Specific
Crops
(
2)
Max
Foliar
Rate
(
lb
ai/
acre)
(
2)
Days
After
Treatment
Target
MOE
Achieved
(
Target
MOE
=
100)

Exposure
Activity
Levels
(
3,4)

Very
Low
Low
Medium
High
Very
High
Vine
/
trellis
(
w/

girdling)
Grapes
(
table
and
raisin)
1
N/
A
0
0
6
12
Vine
/
trellis
(
w/
o
girdling)
Grapes
(
juice
and
wine)
0.65
­
1.3
N/
A
0
0
2
­
8
N/
A
Summary
of
'
Days
After
Treatment'
to
Reach
the
Target
MOE
for
Intermediate­
term
Exposure
Vine
/
trellis
(
w/

girdling)
Grapes
(
table
and
raisin)
1
N/
A
14
21
36
43
Vine
/
trellis
(
w/
o
girdling)
Grapes
(
juice
and
wine)
0.65
­
1.3
N/
A
10
­
17
17
­
23
32
­
39
N/
A
DFR
Data
Summary
No
study
data
was
used
for
this
crop's
assessment.
Page
9
of
13
Exposure
Potential
Transfer
Coefficients
(
cm2/
hr)
(
1)
Activities
(
1)

Used
for
RA
Range
Very
Low
N/
A
N/
A
N/
A
Low
500
197
­
2,302
Irrigation,
Weeding
(
hand),
Scouting,
Hedging
Medium
1000
197
­
2,302
Scouting,
Training,
Tying
High
5000
TBD
Harvest
(
hand),
Pruning
(
hand),
Training,

Tying,
Thinning,
Leaf
Pulling
Very
High
10000
TBD
Girdling,
Turning
(
Cane
turning),
Tying
(
Cane
turning)

Chemical:

Reason:
TC
Policy
3.1
Date:
Assessor:
Applicable
TC
Groups:

Vine
/
trellis
(
w/
girdling)

[
Note:
Only
applicable
TCGroups
are
included
above.]

DFR/
TTR
Data
Defaults:

Initial
Percent
of
Rate
as
DFR
(%):
20
Dissipation
Rate
per
day
(%):
10
Initial
Percent
of
Rate
as
TTR
(%):
5
Dissipation
Rate
per
day
(%):
10
Toxicology
&
Exposure
Factor
Inputs:

Uncertainty
Factor:

Adult
Exposure
Duration
(
hrs/
day):

Dermal
Abs.
(%):
N/
A
Short­
term
NOAEL
(
mg/
kg/
day):
75
Intermediate­
Term
NOAEL
(
mg/
kg/
day):
3
Page
10
of
13
Source
of
Short­
term
NOAEL:

Adult
Body
Weight
(
kg):
70
Sod/
Turf
Farms
Summary
of
'
Days
After
Treatment'
to
Reach
the
Target
MOE
for
Short­
term
Exposure
Crop
Grouping
(
1)
dicofol
­
turf
Specific
Crops
(
2)
Max
Foliar
Rate
(
lb
ai/
acre)
(
2)
Days
After
Treatment
Target
MOE
Achieved
(
Target
MOE
=
100)

Exposure
Activity
Levels
(
3,4)

Very
Low
Low
Medium
High
Very
High
Turf
/
sod
Turf
0.275
­
0.55
N/
A
0
N/
A
0
N/
A
Summary
of
'
Days
After
Treatment'
to
Reach
the
Target
MOE
for
Intermediate­
term
Exposure
Turf
/
sod
Turf
0.275
­
0.55
N/
A
0
N/
A
22
­
29
N/
A
DFR
Data
Summary
No
study
data
was
used
for
this
crop's
assessment.

Exposure
Potential
Transfer
Coefficients
(
cm2/
hr)
(
1)
Activities
(
1)

Used
for
RA
Range
Very
Low
N/
A
N/
A
N/
A
Low
500
N/
A
Mowing
Medium
N/
A
N/
A
N/
A
High
16500
N/
A
Transplanting,
Weeding
(
hand),
Harvest
(
hand),

Harvest
(
mechanical)

Very
High
N/
A
N/
A
N/
A
Exposure
Inputs
Summary
Page
11
of
13
Chemical:
dicofol
­
turf
Date:
2­
2­
05
Assessor:
RT
Transfer
Coefficient
Group:
Turf
/
sod
Specific
Crop
Considered:
Turf
Application
Rate
of
Crop
(
lb
ai/
A):
0.275
Tomatoes/
Peppers
Summary
of
'
Days
After
Treatment'
to
Reach
the
Target
MOE
for
Short­
term
Exposure
Crop
Grouping
(
1)
dicofol
­

tomatoes/
peppers
Specific
Crops
(
2)
Max
Foliar
Rate
(
lb
ai/
acre)
(
2)
Days
After
Treatment
Target
MOE
Achieved
(
Target
MOE
=
100)

Exposure
Activity
Levels
(
3,4)

Very
Low
Low
Medium
High
Very
High
Vegetable,
fruiting
Peppers
(
bell),
Peppers
(
chili),
Tomatoes
(
fresh)
0.75
­
1.5
N/
A
0
0
0
N/
A
Summary
of
'
Days
After
Treatment'
to
Reach
the
Target
MOE
for
Intermediate­
term
Exposure
Vegetable,
fruiting
Peppers
(
bell),
Peppers
(
chili),
Tomatoes
(
fresh)
0.75
­
1.5
N/
A
12
­
18
15
­
21
18
­
25
N/
A
DFR
Data
Summary
No
study
data
was
used
for
this
crop's
assessment.

Exposure
Potential
Transfer
Coefficients
(
cm2/
hr)
(
1)
Activities
(
1)

Used
for
RA
Range
Very
Low
N/
A
N/
A
N/
A
Low
500
486
­
2,760
Weeding
(
hand),
Irrigation,
Scouting,
Thinning
Exposure
Potential
Transfer
Coefficients
(
cm2/
hr)
(
1)
Activities
(
1)

Used
for
RA
Range
Page
12
of
13
Medium
700
TBD
Irrigation,
Scouting,
Pruning
(
hand),
Staking,

Tying
High
1000
364
­
1,908
Harvest
(
hand),
Pruning
(
hand),
Staking,

Thinning,
Training,
Tying
Very
High
N/
A
N/
A
N/
A
Exposure
Inputs
Summary
Chemical:
dicofol
­
tomatoes/
peppers
Date:
2­
2­
05
Assessor:
RT
Transfer
Coefficient
Group:
Vegetable,
fruiting
Specific
Crop
Considered:
Peppers
(
bell)

Application
Rate
of
Crop
(
lb
ai/
A):
0.75
.
Page
13
of
13
